{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:27:38Z","timestamp":1789759658310,"version":"4.0.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["101136676 \u2014 ASFaVIP"],"award-info":[{"award-number":["101136676 \u2014 ASFaVIP"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["101136676 \u2014 ASFaVIP"],"award-info":[{"award-number":["101136676 \u2014 ASFaVIP"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["101136676 \u2014 ASFaVIP"],"award-info":[{"award-number":["101136676 \u2014 ASFaVIP"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["101136676 \u2014 ASFaVIP"],"award-info":[{"award-number":["101136676 \u2014 ASFaVIP"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Vaccines"],"DOI":"10.1038\/s41541-025-01208-8","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T14:49:19Z","timestamp":1751899759000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Benefit risk considerations for African swine fever virus live attenuated vaccines"],"prefix":"10.1038","volume":"10","author":[{"given":"Sandra","family":"Blome","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Friedrichs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Beer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"1208_CR1","doi-asserted-by":"publisher","first-page":"e02017","DOI":"10.1128\/JVI.02017-19","volume":"94","author":"MV Borca","year":"2020","unstructured":"Borca, M. V. et al. Development of a highly effective African swine fever virus vaccine by deletion of the I177L gene results in sterile immunity against the current epidemic Eurasia strain. J. Virol. 94, e02017\u2013e02019 (2020).","journal-title":"J. Virol."},{"key":"1208_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-025-01099-9","volume":"10","author":"E van den Born","year":"2025","unstructured":"van den Born, E. et al. African swine fever virus vaccine strain ASFV-G-\u2206I177L reverts to virulence and negatively affects reproductive performance. NPJ Vaccines 10, 46 (2025).","journal-title":"NPJ Vaccines"},{"key":"1208_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-023-00669-z","volume":"8","author":"P Deutschmann","year":"2023","unstructured":"Deutschmann, P. et al. Assessment of African swine fever vaccine candidate ASFV-G-\u2206MGF in a reversion to virulence study. NPJ Vaccines 8, 78 (2023).","journal-title":"NPJ Vaccines"},{"key":"1208_CR4","doi-asserted-by":"publisher","first-page":"8602","DOI":"10.1128\/JVI.00551-12","volume":"86","author":"T Tamura","year":"2012","unstructured":"Tamura, T. et al. Selection of classical swine fever virus with enhanced pathogenicity reveals synergistic virulence determinants in e2 and ns4b. J. Virol. 86, 8602\u20138613 (2012).","journal-title":"J. Virol."},{"key":"1208_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2024.105484","volume":"182","author":"M Yamashita","year":"2025","unstructured":"Yamashita, M. et al. Efficacy of gpe(-) strain live attenuated vaccine and cp7_e2alf strain recombinant live vaccine (marker vaccine) against Japanese epidemic classical swine fever virus isolated in 2019 and diva discrimination ability of the marker vaccine. Res. Vet. Sci. 182, 105484 (2025).","journal-title":"Res. Vet. Sci."},{"key":"1208_CR6","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.vetmic.2005.11.012","volume":"113","author":"E Thiry","year":"2006","unstructured":"Thiry, E. et al. Recombination in the alphaherpesvirus bovine herpesvirus 1. Vet. Microbiol. 113, 171\u2013177 (2006).","journal-title":"Vet. Microbiol."},{"key":"1208_CR7","doi-asserted-by":"publisher","first-page":"4518","DOI":"10.1016\/j.vaccine.2019.06.059","volume":"37","author":"JM d\u2019Offay","year":"2019","unstructured":"d\u2019Offay, J. M., Fulton, R. W., Fishbein, M., Eberle, R. & Dubovi, E. J. Isolation of a naturally occurring vaccine\/wild-type recombinant bovine herpesvirus type 1 (bohv-1) from an aborted bovine fetus. Vaccine 37, 4518\u20134524 (2019).","journal-title":"Vaccine"},{"key":"1208_CR8","first-page":"183","volume":"42","author":"N Visser","year":"1994","unstructured":"Visser, N. & Rziha, H. J. Is recombination of prv vaccine strains a real problem? Acta Vet. Hung. 42, 183\u2013193 (1994).","journal-title":"Acta Vet. Hung."},{"key":"1208_CR9","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1046\/j.1439-0450.2003.00666.x","volume":"50","author":"T M\u00fcller","year":"2003","unstructured":"M\u00fcller, T., B\u00e4tza, H. J., Schl\u00fcter, H., Conraths, F. J. & Mettenleiter, T. C. Eradication of aujeszky\u2019s disease in Germany. J. Vet. Med. B Infect. Dis. Vet. Public Health 50, 207\u2013213 (2003).","journal-title":"J. Vet. Med. B Infect. Dis. Vet. Public Health"},{"key":"1208_CR10","doi-asserted-by":"crossref","unstructured":"Blome, S., Franzke, K. & Beer, M. African swine fever\u2014a review of current knowledge. 287, 198099 (2020).","DOI":"10.1016\/j.virusres.2020.198099"}],"container-title":["npj Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41541-025-01208-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41541-025-01208-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41541-025-01208-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T14:49:21Z","timestamp":1751899761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41541-025-01208-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1208"],"URL":"https:\/\/doi.org\/10.1038\/s41541-025-01208-8","relation":{},"ISSN":["2059-0105"],"issn-type":[{"value":"2059-0105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]},"assertion":[{"value":"17 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"S.B., V.F., A.S., and M.B. work on the EU-funded project ASFaVIP (African Swine Fever attenuated live Vaccines In Pigs), investigating, among others, the vaccine candidate ASFV-G-\u0394I177L as a potential live-attenuated vaccine for the European market. None of the authors has a direct financial interest in the candidate ASFV-G-\u0394I177L.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"147"}}