{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:37:39Z","timestamp":1790415459881,"version":"4.1.0"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000057","name":"U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01 GM130590"],"award-info":[{"award-number":["R01 GM130590"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat. Biomed. Eng"],"DOI":"10.1038\/s41551-023-01136-9","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T12:02:18Z","timestamp":1701691338000},"page":"1243-1265","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9341-0479","authenticated-orcid":false,"given":"Kin Man","family":"Au","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin E.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny P.-Y.","family":"Ting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9781-4494","authenticated-orcid":false,"given":"Andrew Z.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"1136_CR1","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1056\/NEJMra1102942","volume":"365","author":"S Danese","year":"2011","unstructured":"Danese, S. & Fiocchi, C. Medical progress ulcerative colitis. N. Engl. J. Med. 365, 1713\u20131725 (2011).","journal-title":"N. Engl. J. Med."},{"key":"1136_CR2","first-page":"247","volume":"8","author":"KA Head","year":"2003","unstructured":"Head, K. A. & Jurenka, J. S. Inflammatory bowel disease part 1: ulcerative colitis\u2014pathophysiology and conventional and alternative treatment options. Alter. Med. Rev. 8, 247\u2013283 (2003).","journal-title":"Alter. Med. Rev."},{"key":"1136_CR3","doi-asserted-by":"publisher","first-page":"874","DOI":"10.14309\/ajg.0000000000000183","volume":"114","author":"R Ungaro","year":"2019","unstructured":"Ungaro, R., Colombel, J.-F., Lissoos, T. & Peyrin-Biroulet, L. A treat-to-target update in ulcerative colitis: a systematic review. Am. J. Gastroenterol. 114, 874\u2013883 (2019).","journal-title":"Am. J. Gastroenterol."},{"key":"1136_CR4","doi-asserted-by":"publisher","first-page":"738762","DOI":"10.3389\/fimmu.2021.738762","volume":"12","author":"RC Garduno","year":"2021","unstructured":"Garduno, R. C. & Dabritz, J. New insights on CD8+ T cells in inflammatory bowel disease and therapeutic approaches. Front. Immunol. 12, 738762 (2021).","journal-title":"Front. Immunol."},{"key":"1136_CR5","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s41575-019-0172-4","volume":"16","author":"YR Na","year":"2019","unstructured":"Na, Y. R., Stakenborg, M., Seok, S. H. & Matteoli, G. Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD. Nat. Rev. Gastroenterol. Hepatol. 16, 531\u2013543 (2019).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"1136_CR6","doi-asserted-by":"publisher","first-page":"G59","DOI":"10.1152\/ajpgi.00123.2016","volume":"311","author":"RA Isidro","year":"2016","unstructured":"Isidro, R. A. & Appleyard, C. B. Colonic macrophage polarization in homeostasis, inflammation, and cancer. Am. J. Physiol. Gastrointest. Liver Physiol. 311, G59\u2013G73 (2016).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"1136_CR7","doi-asserted-by":"publisher","first-page":"113","DOI":"10.25122\/jml-2018-0075","volume":"12","author":"SS Seyedian","year":"2019","unstructured":"Seyedian, S. S., Nokhostin, F. & Malamir, M. D. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease. J. Med. Life 12, 113\u2013122 (2019).","journal-title":"J. Med. Life"},{"key":"1136_CR8","doi-asserted-by":"crossref","unstructured":"Dahlgren, D., Agr\u00e9us, L., St\u00e5lhammar, J. & Hellstr\u00f6m, P. M. Ulcerative colitis progression: a retrospective analysis of disease burden using electronic medical records. Ups. J. Med. Sci. 127, e8833 (2022).","DOI":"10.48101\/ujms.v127.8833"},{"key":"1136_CR9","doi-asserted-by":"publisher","first-page":"551","DOI":"10.3389\/fimmu.2015.00551","volume":"6","author":"I Loddo","year":"2015","unstructured":"Loddo, I. & Romano, C. Inflammatory bowel disease: genetics, epigenetics, and pathogenesis. Front. Immunol. 6, 551 (2015).","journal-title":"Front. Immunol."},{"key":"1136_CR10","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.trsl.2006.11.009","volume":"149","author":"MG Neuman","year":"2007","unstructured":"Neuman, M. G. Immune dysfunction in inflammatory bowel disease. Transl. Res. 149, 173\u2013186 (2007).","journal-title":"Transl. Res."},{"key":"1136_CR11","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.3748\/wjg.v20.i12.3146","volume":"20","author":"T Zenlea","year":"2014","unstructured":"Zenlea, T. & Peppercorn, M. A. Immunosuppressive therapies for inflammatory bowel disease. World J. Gastroenterol. 20, 3146\u20133152 (2014).","journal-title":"World J. Gastroenterol."},{"key":"1136_CR12","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1136\/gut.2005.078055","volume":"55","author":"BE Sands","year":"2006","unstructured":"Sands, B. E. Immunosuppressive drugs in ulcerative colitis: twisting facts to suit theories? Gut 55, 437\u2013441 (2006).","journal-title":"Gut"},{"key":"1136_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0673-8","volume":"14","author":"JA Singh","year":"2016","unstructured":"Singh, J. A., Hossain, A., Kotb, A. & Wells, G. Risk of serious infections with immunosuppressive drugs and glucocorticoids for lupus nephritis: a systematic review and network meta-analysis. BMC Med. 14, 137 (2016).","journal-title":"BMC Med."},{"key":"1136_CR14","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0300-483X(02)00612-1","volume":"185","author":"T Vial","year":"2003","unstructured":"Vial, T. Immunosuppressive drugs and cancer. Toxicology 185, 229\u2013240 (2003).","journal-title":"Toxicology"},{"key":"1136_CR15","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1056\/NEJMe058018","volume":"352","author":"J Dantal","year":"2005","unstructured":"Dantal, J. & Soulillou, J.-P. Immunosuppressive drugs and the risk of cancer after organ transplantation. N. Engl. J. Med. 352, 1371\u20131373 (2005).","journal-title":"N. Engl. J. Med."},{"key":"1136_CR16","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.coi.2010.08.006","volume":"22","author":"CA Sabatos-Peyton","year":"2010","unstructured":"Sabatos-Peyton, C. A., Verhagen, J. & Wraith, D. C. Antigen-specific immunotherapy of autoimmune and allergic diseases. Curr. Opin. Immunol. 22, 609\u2013615 (2010).","journal-title":"Curr. Opin. Immunol."},{"key":"1136_CR17","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/nature17300","volume":"530","author":"D Wraith","year":"2016","unstructured":"Wraith, D. Autoimmunity: antigen-specific immunotherapy. Nature 530, 422\u2013423 (2016).","journal-title":"Nature"},{"key":"1136_CR18","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/nature16962","volume":"530","author":"X Clemente-Casares","year":"2016","unstructured":"Clemente-Casares, X. et al. Expanding antigen-specific regulatory networks to treat autoimmunity. Nature 530, 434\u2013440 (2016).","journal-title":"Nature"},{"key":"1136_CR19","doi-asserted-by":"publisher","first-page":"eaaw9668","DOI":"10.1126\/scitranslmed.aaw9668","volume":"13","author":"X Chen","year":"2021","unstructured":"Chen, X. et al. Modular immune-homeostatic microparticles promote immune tolerance in mouse autoimmune models. Sci. Transl. Med. 13, eaaw9668 (2021).","journal-title":"Sci. Transl. Med."},{"key":"1136_CR20","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1208\/s12248-013-9510-6","volume":"15","author":"AM Fathallah","year":"2013","unstructured":"Fathallah, A. M., Bankert, R. B. & Balu-Iyer, S. V. Immunogenicity of subcutaneously administered therapeutic proteins\u2014a mechanistic perspective. AAPS J. 15, 897\u2013900 (2013).","journal-title":"AAPS J."},{"key":"1136_CR21","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1080\/21645515.2020.1814094","volume":"17","author":"IF Cook","year":"2021","unstructured":"Cook, I. F. Subcutaneous vaccine administration\u2014an outmoded practice. Hum. Vaccin. Immunother. 17, 1329\u20131341 (2021).","journal-title":"Hum. Vaccin. Immunother."},{"key":"1136_CR22","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.cell.2019.10.015","volume":"179","author":"Y Wang","year":"2019","unstructured":"Wang, Y. et al. Long-term culture captures injury\u2013repair cycles of colonic stem cells. Cell 179, 1144\u20131159.e15 (2019).","journal-title":"Cell"},{"key":"1136_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jss.2010.04.037","volume":"167","author":"MD Neal","year":"2011","unstructured":"Neal, M. D., Richardson, W. M., Sodhi, C. P., Russo, A. & Hackam, D. J. Intestinal stem cells and their roles during mucosal injury and repair. J. Surg. Res. 167, 1\u20138 (2011).","journal-title":"J. Surg. Res."},{"key":"1136_CR24","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1600-065X.2010.00923.x","volume":"236","author":"LM Francisco","year":"2010","unstructured":"Francisco, L. M., Sage, P. T. & Sharpe, A. H. The PD-1 pathway in tolerance and autoimmunity. Immunol. Rev. 236, 219\u2013242 (2010).","journal-title":"Immunol. Rev."},{"key":"1136_CR25","doi-asserted-by":"publisher","first-page":"e2101253","DOI":"10.1002\/adma.202101253","volume":"33","author":"KM Au","year":"2021","unstructured":"Au, K. M., Medik, Y., Ke, Q., Tisch, R. & Wang, A. Z. Immune checkpoint-bioengineered beta cell vaccine reverses early-onset type 1 diabetes. Adv. Mater. 33, e2101253 (2021).","journal-title":"Adv. Mater."},{"key":"1136_CR26","doi-asserted-by":"publisher","first-page":"e2107392","DOI":"10.1002\/adma.202107392","volume":"34","author":"KM Au","year":"2021","unstructured":"Au, K. M., Tisch, R. & Wang, A. Z. Immune checkpoint ligand bioengineered schwann cells as antigen-specific therapy for experimental autoimmune encephalomyelitis. Adv. Mater. 34, e2107392 (2021).","journal-title":"Adv. Mater."},{"key":"1136_CR27","doi-asserted-by":"publisher","first-page":"112575","DOI":"10.1016\/j.yexcr.2021.112575","volume":"402","author":"Y Wei","year":"2021","unstructured":"Wei, Y. et al. PD-L1 induces macrophage polarization toward the M2 phenotype via Erk\/Akt\/mTOR. Exp. Cell. Res. 402, 112575 (2021).","journal-title":"Exp. Cell. Res."},{"key":"1136_CR28","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.4049\/jimmunol.164.5.2444","volume":"164","author":"E Dahlen","year":"2000","unstructured":"Dahlen, E., Hedlund, G. & Dawe, K. Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation. J. Immunol. 164, 2444\u20132456 (2000).","journal-title":"J. Immunol."},{"key":"1136_CR29","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1517\/14728214.8.1.47","volume":"8","author":"JM Kovarik","year":"2003","unstructured":"Kovarik, J. M. & Burtin, P. Immunosuppressants in advanced clinical development for organ transplantation and selected autoimmune diseases. Expert Opin. Emerg. Drugs 8, 47\u201362 (2003).","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"1136_CR30","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1136\/ard.62.4.297","volume":"62","author":"M Cutolo","year":"2003","unstructured":"Cutolo, M. et al. Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis. Ann. Rheum. Dis. 62, 297\u2013302 (2003).","journal-title":"Ann. Rheum. Dis."},{"key":"1136_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01886-6","volume":"8","author":"CJC Johnston","year":"2017","unstructured":"Johnston, C. J. C. et al. A structurally distinct TGF-beta mimic from an intestinal helminth parasite potently induces regulatory T cells. Nat. Commun. 8, 1741 (2017).","journal-title":"Nat. Commun."},{"key":"1136_CR32","doi-asserted-by":"publisher","first-page":"e0136116","DOI":"10.1371\/journal.pone.0136116","volume":"10","author":"ER Vaz","year":"2015","unstructured":"Vaz, E. R. et al. A short peptide that mimics the binding domain of TGF-beta 1 presents potent anti-inflammatory activity. PLoS ONE 10, e0136116 (2015).","journal-title":"PLoS ONE"},{"key":"1136_CR33","doi-asserted-by":"publisher","first-page":"52294","DOI":"10.18632\/oncotarget.10561","volume":"7","author":"F Zhang","year":"2016","unstructured":"Zhang, F. et al. TGF-beta induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype. Oncotarget 7, 52294\u201352306 (2016).","journal-title":"Oncotarget"},{"key":"1136_CR34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1471-2172-13-31","volume":"13","author":"D Gong","year":"2012","unstructured":"Gong, D. et al. TGF beta signaling plays a critical role in promoting alternative macrophage activation. BMC Immunol. 13, 31 (2012).","journal-title":"BMC Immunol."},{"key":"1136_CR35","doi-asserted-by":"publisher","first-page":"30221","DOI":"10.1021\/acsami.0c09054","volume":"12","author":"C Cao","year":"2020","unstructured":"Cao, C., Chen, F., Garvey, C. J. & Stenzel, M. H. Drug-directed morphology changes in polymerization-induced self-assembly (PISA) influence the biological behavior of nanoparticles. ACS Appl. Mater. Interfaces 12, 30221\u201330233 (2020).","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"1136_CR36","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.polymer.2016.08.082","volume":"106","author":"AB Lowe","year":"2016","unstructured":"Lowe, A. B. RAFT alcoholic dispersion polymerization with polymerization-induced self-assembly. Polymer 106, 161\u2013181 (2016).","journal-title":"Polymer"},{"key":"1136_CR37","doi-asserted-by":"publisher","first-page":"15707","DOI":"10.1021\/ja205887v","volume":"133","author":"S Sugihara","year":"2011","unstructured":"Sugihara, S., Blanazs, A., Armes, S. P., Ryan, A. J. & Lewis, A. L. Aqueous dispersion polymerization: a new paradigm for in situ block copolymer self-assembly in concentrated solution. J. Am. Chem. Soc. 133, 15707\u201315713 (2011).","journal-title":"J. Am. Chem. Soc."},{"key":"1136_CR38","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1107\/S0021889809002222","volume":"42","author":"J Ilavsky","year":"2009","unstructured":"Ilavsky, J. & Jemian, P. R. Irena: tool suite for modeling and analysis of small-angle scattering. J. Appl. Crystallogr. 42, 347\u2013353 (2009).","journal-title":"J. Appl. Crystallogr."},{"key":"1136_CR39","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nbt.3586","volume":"34","author":"HJ Chen","year":"2016","unstructured":"Chen, H. J. et al. A recellularized human colon model identifies cancer driver genes. Nat. Biotechnol. 34, 845\u2013851 (2016).","journal-title":"Nat. Biotechnol."},{"key":"1136_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13605-4","volume":"10","author":"GG Giobbe","year":"2019","unstructured":"Giobbe, G. G. et al. Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture. Nat. Commun. 10, 5658 (2019).","journal-title":"Nat. Commun."},{"key":"1136_CR41","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/j.1365-2249.2008.03799.x","volume":"155","author":"PJ Mannon","year":"2009","unstructured":"Mannon, P. J. et al. Successful granulocyte-colony stimulating factor treatment of Crohn\u2019s disease is associated with the appearance of circulating interleukin-10-producing T cells and increased lamina propria plasmacytoid dendritic cells. Clin. Exp. Immunol. 155, 447\u2013456 (2009).","journal-title":"Clin. Exp. Immunol."},{"key":"1136_CR42","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/00054725-199902000-00007","volume":"5","author":"PL Beck","year":"1999","unstructured":"Beck, P. L. & Podolsky, D. K. Growth factors in inflammatory bowel disease. Inflamm. Bowel Dis. 5, 44\u201360 (1999).","journal-title":"Inflamm. Bowel Dis."},{"key":"1136_CR43","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/ibd.20279","volume":"14","author":"SK Sainathan","year":"2008","unstructured":"Sainathan, S. K. et al. Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis. Inflamm. Bowel Dis. 14, 88\u201399 (2008).","journal-title":"Inflamm. Bowel Dis."},{"key":"1136_CR44","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1038\/s41591-020-1024-z","volume":"26","author":"L Meran","year":"2020","unstructured":"Meran, L. et al. Engineering transplantable jejunal mucosal grafts using patient-derived organoids from children with intestinal failure. Nat. Med. 26, 1593\u20131601 (2020).","journal-title":"Nat. Med."},{"key":"1136_CR45","doi-asserted-by":"publisher","first-page":"355","DOI":"10.4329\/wjr.v8.i4.355","volume":"8","author":"R Singh","year":"2016","unstructured":"Singh, R., Singh, D. & Singh, A. Radiation sterilization of tissue allografts: a review. World J. Radiol. 8, 355\u2013369 (2016).","journal-title":"World J. Radiol."},{"key":"1136_CR46","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41551-022-00964-5","volume":"7","author":"MT Spang","year":"2023","unstructured":"Spang, M. T. et al. Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues. Nat. Biomed. Eng. 7, 94\u2013109 (2023).","journal-title":"Nat. Biomed. Eng."},{"key":"1136_CR47","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.stem.2022.12.010","volume":"30","author":"Z Alvarez","year":"2023","unstructured":"Alvarez, Z. et al. Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons. Cell Stem Cell 30, 219\u2013238.e14 (2023).","journal-title":"Cell Stem Cell"},{"key":"1136_CR48","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0022-1759(03)00010-3","volume":"275","author":"A Trickett","year":"2003","unstructured":"Trickett, A. & Kwan, Y. L. T cell stimulation and expansion using anti-CD3\/CD28 beads. J. Immunol. Methods 275, 251\u2013255 (2003).","journal-title":"J. Immunol. Methods"},{"key":"1136_CR49","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.immuni.2016.05.001","volume":"44","author":"AC Anderson","year":"2016","unstructured":"Anderson, A. C., Joller, N. & Kuchroo, V. K. Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation. Immunity 44, 989\u20131004 (2016).","journal-title":"Immunity"},{"key":"1136_CR50","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0022-1759(00)00231-3","volume":"243","author":"AB Lyons","year":"2000","unstructured":"Lyons, A. B. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J. Immunol. Methods 243, 147\u2013154 (2000).","journal-title":"J. Immunol. Methods"},{"key":"1136_CR51","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1002\/eji.1830040802","volume":"4","author":"GM Shearer","year":"1974","unstructured":"Shearer, G. M. Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes. Eur. J. Immunol. 4, 527\u2013533 (1974).","journal-title":"Eur. J. Immunol."},{"key":"1136_CR52","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1053\/j.gastro.2006.05.018","volume":"131","author":"S Nancey","year":"2006","unstructured":"Nancey, S. et al. CD8+ cytotoxic T cells induce relapsing colitis in normal mice. Gastroenterology 131, 485\u2013496 (2006).","journal-title":"Gastroenterology"},{"key":"1136_CR53","doi-asserted-by":"publisher","first-page":"15.25.1","DOI":"10.1002\/0471142735.im1525s104","volume":"104","author":"B Chassaing","year":"2014","unstructured":"Chassaing, B., Aitken, J. D., Malleshappa, M. & Vijay-Kumar, M. Dextran sulfate sodium (DSS)-induced colitis in mice. Curr. Protoc. Immunol. 104, 15.25.1\u201315.25.14 (2014).","journal-title":"Curr. Protoc. Immunol."},{"key":"1136_CR54","doi-asserted-by":"publisher","first-page":"6016","DOI":"10.3748\/wjg.v23.i33.6016","volume":"23","author":"DD Eichele","year":"2017","unstructured":"Eichele, D. D. & Kharbanda, K. K. Dextran sodium sulfate colitis murine model: an indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis. World J. Gastroenterol. 23, 6016\u20136029 (2017).","journal-title":"World J. Gastroenterol."},{"key":"1136_CR55","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","volume":"75","author":"R Kuhn","year":"1993","unstructured":"Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. & Muller, W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263\u2013274 (1993).","journal-title":"Cell"},{"key":"1136_CR56","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.healun.2018.05.002","volume":"37","author":"KL Flannigan","year":"2018","unstructured":"Flannigan, K. L. et al. An intact microbiota is required for the gastrointestinal toxicity of the immunosuppressant mycophenolate mofetil. J. Heart Lung Transpl. 37, 1047\u20131059 (2018).","journal-title":"J. Heart Lung Transpl."},{"key":"1136_CR57","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.4049\/jimmunol.2001317","volume":"206","author":"BM Johnson","year":"2021","unstructured":"Johnson, B. M. et al. STING agonist mitigates experimental autoimmune encephalomyelitis by stimulating type I IFN-dependent and -independent immune-regulatory pathways. J. Immunol. 206, 2015\u20132028 (2021).","journal-title":"J. Immunol."},{"key":"1136_CR58","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.actbio.2019.11.012","volume":"101","author":"JY Hong","year":"2020","unstructured":"Hong, J. Y. et al. Decellularized brain matrix enhances macrophage polarization and functional improvements in rat spinal cord injury. Acta Biomater. 101, 357\u2013371 (2020).","journal-title":"Acta Biomater."},{"key":"1136_CR59","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1002\/ibd.22973","volume":"18","author":"L Roth","year":"2012","unstructured":"Roth, L., MacDonald, J. K., McDonald, J. W. & Chande, N. Sargramostim (GM-CSF) for induction of remission in Crohn\u2019s disease: a cochrane inflammatory bowel disease and functional bowel disorders systematic review of randomized trials. Inflamm. Bowel Dis. 18, 1333\u20131339 (2012).","journal-title":"Inflamm. Bowel Dis."},{"key":"1136_CR60","doi-asserted-by":"publisher","unstructured":"Giuffrida, E. et al. Risk of colorectal cancer in inflammatory bowel disease: prevention and monitoring strategies according with risk factors. Clin. Manag. Issues https:\/\/doi.org\/10.7175\/cmi.v15i1.1464 (2021).","DOI":"10.7175\/cmi.v15i1.1464"},{"key":"1136_CR61","doi-asserted-by":"publisher","first-page":"3937","DOI":"10.3748\/wjg.14.3937","volume":"14","author":"PL Lakatos","year":"2008","unstructured":"Lakatos, P. L. & Lakatos, L. Risk for colorectal cancer in ulcerative colitis: changes, causes and management strategies. World J. Gastroenterol. 14, 3937\u20133947 (2008).","journal-title":"World J. Gastroenterol."},{"key":"1136_CR62","doi-asserted-by":"publisher","first-page":"9","DOI":"10.4103\/1477-3163.78279","volume":"10","author":"M De Robertis","year":"2011","unstructured":"De Robertis, M. et al. The AOM\/DSS murine model for the study of colon carcinogenesis: from pathways to diagnosis and therapy studies. J. Carcinog. 10, 9 (2011).","journal-title":"J. Carcinog."},{"key":"1136_CR63","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/978-1-4939-3603-8_26","volume":"1422","author":"B Parang","year":"2016","unstructured":"Parang, B., Barrett, C. W. & Williams, C. S. AOM\/DSS model of colitis-associated cancer. Methods Mol. Biol. 1422, 297\u2013307 (2016).","journal-title":"Methods Mol. Biol."},{"key":"1136_CR64","doi-asserted-by":"publisher","first-page":"4817","DOI":"10.2147\/OTT.S142264","volume":"11","author":"FA Mensah","year":"2018","unstructured":"Mensah, F. A., Blaize, J. P. & Bryan, L. J. Spotlight on copanlisib and its potential in the treatment of relapsed\/refractory follicular lymphoma: evidence to date. Onco Targets Ther. 11, 4817\u20134827 (2018).","journal-title":"Onco Targets Ther."},{"key":"1136_CR65","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/s41571-021-00512-1","volume":"18","author":"D Killock","year":"2021","unstructured":"Killock, D. Copanlisib safe and active in combination. Nat. Rev. Clin. Oncol. 18, 322 (2021).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"1136_CR66","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/s41586-022-04685-2","volume":"605","author":"S Eschweiler","year":"2022","unstructured":"Eschweiler, S. et al. Intermittent PI3K delta inhibition sustains anti-tumour immunity and curbs irAEs. Nature 605, 741\u2013746 (2022).","journal-title":"Nature"},{"key":"1136_CR67","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03154-w","volume":"11","author":"J Yan","year":"2020","unstructured":"Yan, J., Yang, S., Tian, H., Zhang, Y. & Zhao, H. Copanlisib promotes growth inhibition and apoptosis by modulating the AKT\/FoxO3a\/PUMA axis in colorectal cancer. Cell Death Dis. 11, 943 (2020).","journal-title":"Cell Death Dis."},{"key":"1136_CR68","doi-asserted-by":"publisher","first-page":"405","DOI":"10.12998\/wjcc.v7.i4.405","volume":"7","author":"A Som","year":"2019","unstructured":"Som, A. et al. Immune checkpoint inhibitor-induced colitis: a comprehensive review. World J. Clin. Cases 7, 405\u2013418 (2019).","journal-title":"World J. Clin. Cases"},{"key":"1136_CR69","doi-asserted-by":"publisher","first-page":"768957","DOI":"10.3389\/fimmu.2021.768957","volume":"12","author":"H Westdorp","year":"2021","unstructured":"Westdorp, H. et al. Mechanisms of immune checkpoint inhibitor-mediated colitis. Front. Immunol. 12, 768957 (2021).","journal-title":"Front. Immunol."},{"key":"1136_CR70","doi-asserted-by":"crossref","unstructured":"Wolchok, J. D., Rollin, L. & Larkin, J. Nivolumab and ipilimumab in advanced melanoma. N. Engl. J. Med. 377, 2503\u20132504 (2017).","DOI":"10.1056\/NEJMc1714339"},{"key":"1136_CR71","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1056\/NEJMoa1712126","volume":"378","author":"RJ Motzer","year":"2018","unstructured":"Motzer, R. J. et al. Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma. N. Engl. J. Med. 378, 1277\u20131290 (2018).","journal-title":"N. Engl. J. Med."},{"key":"1136_CR72","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1056\/NEJMoa1801946","volume":"378","author":"MD Hellmann","year":"2018","unstructured":"Hellmann, M. D. et al. Nivolumab plus ipilimumab in lung cancer with a high tumour mutational burden. N. Engl. J. Med. 378, 2093\u20132104 (2018).","journal-title":"N. Engl. J. Med."},{"key":"1136_CR73","doi-asserted-by":"publisher","first-page":"2000274","DOI":"10.1002\/adtp.202000274","volume":"4","author":"MI Bury","year":"2021","unstructured":"Bury, M. I. et al. Self\u2010assembling nanofibers inhibit inflammation in a murine model of Crohn\u2019s\u2010disease\u2010like ileitis. Adv. Ther. 4, 2000274 (2021).","journal-title":"Adv. Ther."},{"key":"1136_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.reth.2019.11.004","volume":"13","author":"R Okamoto","year":"2020","unstructured":"Okamoto, R. et al. Organoid-based regenerative medicine for inflammatory bowel disease. Regen. Ther. 13, 1\u20136 (2020).","journal-title":"Regen. Ther."},{"key":"1136_CR75","doi-asserted-by":"publisher","first-page":"3418","DOI":"10.1021\/acs.jmedchem.6b00088","volume":"59","author":"P Sharma","year":"2016","unstructured":"Sharma, P., Gangopadhyay, D., Mishra, P. C., Mishra, H. & Singh, R. K. Detection of in vitro metabolite formation of leflunomide: a fluorescence dynamics and electronic structure study. J. Med. Chem. 59, 3418\u20133426 (2016).","journal-title":"J. Med. Chem."},{"key":"1136_CR76","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1128\/CDLI.8.6.1131-1135.2001","volume":"8","author":"S Neri","year":"2001","unstructured":"Neri, S., Mariani, E., Meneghetti, A., Cattini, L. & Facchini, A. Calcein-acetyoxymethyl cytotoxicity assay: standardization of a method allowing additional analyses on recovered effector cells and supernatants. Clin. Diagn. Lab. Immunol. 8, 1131\u20131135 (2001).","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"1136_CR77","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1546-9","volume":"15","author":"M Genin","year":"2015","unstructured":"Genin, M., Clement, F., Fattaccioli, A., Raes, M. & Michiels, C. M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide. BMC Cancer 15, 577 (2015).","journal-title":"BMC Cancer"},{"key":"1136_CR78","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","volume":"10","author":"M Orecchioni","year":"2019","unstructured":"Orecchioni, M., Ghosheh, Y., Pramod, A. B. & Ley, K. Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS-) vs. alternatively activated macrophages. Front. Immunol. 10, 1084 (2019).","journal-title":"Front. Immunol."},{"key":"1136_CR79","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.cell.2010.01.023","volume":"140","author":"WS Garrett","year":"2010","unstructured":"Garrett, W. S., Gordon, J. I. & Glimcher, L. H. Homeostasis and inflammation in the intestine. Cell 140, 859\u2013870 (2010).","journal-title":"Cell"}],"updated-by":[{"DOI":"10.1038\/s41551-024-01232-4","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000}}],"container-title":["Nature Biomedical Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41551-023-01136-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41551-023-01136-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41551-023-01136-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T14:02:46Z","timestamp":1729087366000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41551-023-01136-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,4]]},"references-count":79,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["1136"],"URL":"https:\/\/doi.org\/10.1038\/s41551-023-01136-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.10.03.560652","asserted-by":"object"}]},"ISSN":["2157-846X"],"issn-type":[{"value":"2157-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,4]]},"assertion":[{"value":"5 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41551-024-01232-4","URL":"https:\/\/doi.org\/10.1038\/s41551-024-01232-4","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The University of Texas Southwestern Medical Center filed a patent application on the technology and intellectual property reported in this work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}