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B.G. is an inventor on patent applications involving targeting ferroptosis in cancer therapy and reports personal fees from Guidepoint Global, Cambridge Solutions and NGM Bio. D.I.G. is an employee and shareholder of AstraZeneca. V.G.S. serves as an advisor to, and\/or has equity, in Branch Biosciences, Ensoma and Cellarity (all unrelated to the present work). L.G. has\/had research contracts with Lytix Biopharma, Promontory and Onxeo; received consulting\/advisory honoraria from Boehringer Ingelheim, AstraZeneca, OmniSEQ, Onxeo, The Longevity Labs, Inzen, Imvax, Sotio, Promontory, Noxopharm, EduCom and the Luke Heller TECPR2 Foundation; and holds Promontory stock options. A.I.B. holds shares in Cogstate Ltd, Alterity Ltd and a profit share with Collaborative Medicinal Development LLC, and acts as a paid consultant to Collaborative Medicinal Development LLC. X.J. is an inventor of patents related to autophagy and cell death, and holds equity in, and also consults for, Exarta Therapeutics and Lime Therapeutics. G.K. has research contracts with Daiichi Sankyo, Eleor, Kaleido, Lytix Pharma, PharmaMar, Osasuna Therapeutics, Samsara Therapeutics, Sanofi, Tollys, and Vascage; is on the Board of Directors of the Bristol Myers Squibb Foundation France; is a scientific cofounder of everImmune, Osasuna Therapeutics, Samsara Therapeutics and Therafast Bio; is on the scientific advisory boards of Hevolution, Institut Servier and Longevity Vision Funds; and is the inventor of patents covering therapeutic targeting of ageing, cancer, cystic fibrosis and metabolic disorders. G.K.\u2019s wife, L. Zitvogel, has held research contracts with GlaxoSmithKline, Incyte, Lytix, Kaleido, Innovate Pharma, Daiichi Sankyo, Pilege, Merus, Transgene, 9\u2009m, Tusk and Roche; she was on the Board of Directors of Transgene, is a cofounder of everImmune and holds patents covering the treatment of cancer and the therapeutic manipulation of the microbiota. G.K.\u2019s brother, R. Kroemer, was an employee of Sanofi and now consults for Boehringer Ingelheim. The remaining authors declare no competing interests. The funders had no role in the writing of the manuscript.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}