{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:57:21Z","timestamp":1791345441055,"version":"4.3.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["NCI K99CA279899"],"award-info":[{"award-number":["NCI K99CA279899"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"U.S. Department of Health & Human Services | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["NCI CA183878, NCI CA251950, NCI CA221946, NCI CA227904,NCI CA253533"],"award-info":[{"award-number":["NCI CA183878, NCI CA251950, NCI CA221946, NCI CA227904,NCI CA253533"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1038\/s41556-024-01508-6","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T18:03:50Z","timestamp":1726509830000},"page":"1971-1983","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Solid tumour-induced systemic immunosuppression involves dichotomous myeloid\u2013B cell interactions"],"prefix":"10.1038","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8763-3529","authenticated-orcid":false,"given":"Xiaoxin","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6649-7991","authenticated-orcid":false,"given":"Angela","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5786-4315","authenticated-orcid":false,"given":"Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1832-4380","authenticated-orcid":false,"given":"Yang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4651-7710","authenticated-orcid":false,"given":"Fengshuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6882-4274","authenticated-orcid":false,"given":"Hilda L.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0660-1125","authenticated-orcid":false,"given":"Che-Hsing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6462-6067","authenticated-orcid":false,"given":"Weijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Nasrazadani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto T.","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bora","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-8670","authenticated-orcid":false,"given":"Xiang H.-F.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"1508_CR1","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/ncb3015","volume":"16","author":"SS McAllister","year":"2014","unstructured":"McAllister, S. S. & Weinberg, R. A. The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis. Nat. Cell Biol. 16, 717\u2013727 (2014).","journal-title":"Nat. Cell Biol."},{"key":"1508_CR2","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/s41568-021-00347-z","volume":"21","author":"KJ Hiam-Galvez","year":"2021","unstructured":"Hiam-Galvez, K. J., Allen, B. M. & Spitzer, M. H. Systemic immunity in cancer. Nat. Rev. Cancer 21, 345\u2013359 (2021).","journal-title":"Nat. Rev. Cancer"},{"key":"1508_CR3","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1387\/ijdb.113366zc","volume":"55","author":"Z Castano","year":"2011","unstructured":"Castano, Z., Tracy, K. & McAllister, S. S. The tumor macroenvironment and systemic regulation of breast cancer progression. Int. J. Dev. Biol. 55, 889\u2013897 (2011).","journal-title":"Int. J. Dev. Biol."},{"key":"1508_CR4","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/s41568-020-0281-y","volume":"20","author":"S Jaillon","year":"2020","unstructured":"Jaillon, S. et al. Neutrophil diversity and plasticity in tumour progression and therapy. Nat. Rev. Cancer 20, 485\u2013503 (2020).","journal-title":"Nat. Rev. Cancer"},{"key":"1508_CR5","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/nri2506","volume":"9","author":"DI Gabrilovich","year":"2009","unstructured":"Gabrilovich, D. I. & Nagaraj, S. Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162\u2013174 (2009).","journal-title":"Nat. Rev. Immunol."},{"key":"1508_CR6","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.stem.2023.04.005","volume":"30","author":"X Hao","year":"2023","unstructured":"Hao, X. et al. Osteoprogenitor\u2013GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal. Cell Stem Cell 30, 648\u2013664 e648 (2023).","journal-title":"Cell Stem Cell"},{"key":"1508_CR7","doi-asserted-by":"crossref","unstructured":"Vale, A. M., Kearney, J. F., Nobrega, A. & Schroeder, H. W. in Molecular Biology of B Cells 2nd ed. (eds Alt, F. W., Honjo, T., Radbruch, A. & Reth, M.) 99\u2013119 (2015).","DOI":"10.1016\/B978-0-12-397933-9.00007-2"},{"key":"1508_CR8","doi-asserted-by":"publisher","unstructured":"Aurrand-Lions, M. & Mancini, S. J. C. Murine bone marrow niches from hematopoietic stem cells to B cells. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms19082353 (2018).","DOI":"10.3390\/ijms19082353"},{"key":"1508_CR9","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/cmi.2017.35","volume":"14","author":"A Sarvaria","year":"2017","unstructured":"Sarvaria, A., Madrigal, J. A. & Saudemont, A. B cell regulation in cancer and anti-tumor immunity. Cell Mol. Immunol. 14, 662\u2013674 (2017).","journal-title":"Cell Mol. Immunol."},{"key":"1508_CR10","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1093\/intimm\/dxv034","volume":"27","author":"Y Zhang","year":"2015","unstructured":"Zhang, Y., Gallastegui, N. & Rosenblatt, J. D. Regulatory B cells in anti-tumor immunity. Int. Immunol. 27, 521\u2013530 (2015).","journal-title":"Int. Immunol."},{"key":"1508_CR11","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3390\/cells8050449","volume":"8","author":"A Largeot","year":"2019","unstructured":"Largeot, A., Pagano, G., Gonder, S., Moussay, E. & Paggetti, J. The B-side of cancer immunity: the underrated tune. Cells 8, 449 (2019).","journal-title":"Cells"},{"key":"1508_CR12","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s12282-017-0824-6","volume":"25","author":"B Tsuda","year":"2018","unstructured":"Tsuda, B. et al. B-cell populations are expanded in breast cancer patients compared with healthy controls. Breast Cancer 25, 284\u2013291 (2018).","journal-title":"Breast Cancer"},{"key":"1508_CR13","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/s41591-018-0309-y","volume":"25","author":"Y Gu","year":"2019","unstructured":"Gu, Y. et al. Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG. Nat. Med. 25, 312\u2013322 (2019).","journal-title":"Nat. Med."},{"key":"1508_CR14","doi-asserted-by":"publisher","first-page":"5826","DOI":"10.1158\/0008-5472.CAN-19-1058","volume":"79","author":"E Ragonnaud","year":"2019","unstructured":"Ragonnaud, E. et al. Tumor-derived thymic stromal lymphopoietin expands bone marrow B-cell precursors in circulation to support metastasis. Cancer Res. 79, 5826\u20135838 (2019).","journal-title":"Cancer Res."},{"key":"1508_CR15","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/s41586-019-1922-8","volume":"577","author":"BA Helmink","year":"2020","unstructured":"Helmink, B. A. et al. B cells and tertiary lymphoid structures promote immunotherapy response. Nature 577, 549\u2013555 (2020).","journal-title":"Nature"},{"key":"1508_CR16","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf9419","volume":"375","author":"TN Schumacher","year":"2022","unstructured":"Schumacher, T. N. & Thommen, D. S. Tertiary lymphoid structures in cancer. Science 375, eabf9419 (2022).","journal-title":"Science"},{"key":"1508_CR17","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.cell.2019.10.028","volume":"179","author":"DP Hollern","year":"2019","unstructured":"Hollern, D. P. et al. B cells and T follicular helper cells mediate response to checkpoint inhibitors in high mutation burden mouse models of breast cancer. Cell 179, 1191\u20131206 e1121 (2019).","journal-title":"Cell"},{"key":"1508_CR18","doi-asserted-by":"publisher","first-page":"3818","DOI":"10.1158\/1078-0432.CCR-13-3368","volume":"20","author":"MD Iglesia","year":"2014","unstructured":"Iglesia, M. D. et al. Prognostic B-cell signatures using mRNA-seq in patients with subtype-specific breast and ovarian cancer. Clin. Cancer Res. 20, 3818\u20133829 (2014).","journal-title":"Clin. Cancer Res."},{"key":"1508_CR19","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/s41586-019-1906-8","volume":"577","author":"F Petitprez","year":"2020","unstructured":"Petitprez, F. et al. B cells are associated with survival and immunotherapy response in sarcoma. Nature 577, 556\u2013560 (2020).","journal-title":"Nature"},{"key":"1508_CR20","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S1074-7613(00)80268-X","volume":"5","author":"YS Li","year":"1996","unstructured":"Li, Y. S., Wasserman, R., Hayakawa, K. & Hardy, R. R. Identification of the earliest B lineage stage in mouse bone marrow. Immunity 5, 527\u2013535 (1996).","journal-title":"Immunity"},{"key":"1508_CR21","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nri1780","volume":"6","author":"T Nagasawa","year":"2006","unstructured":"Nagasawa, T. Microenvironmental niches in the bone marrow required for B-cell development. Nat. Rev. Immunol. 6, 107\u2013116 (2006).","journal-title":"Nat. Rev. Immunol."},{"key":"1508_CR22","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.1182\/blood-2009-08-239210","volume":"115","author":"KT Greig","year":"2010","unstructured":"Greig, K. T. et al. Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood 115, 2796\u20132805 (2010).","journal-title":"Blood"},{"key":"1508_CR23","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.immuni.2015.04.005","volume":"42","author":"EC Rosser","year":"2015","unstructured":"Rosser, E. C. & Mauri, C. Regulatory B cells: origin, phenotype, and function. Immunity 42, 607\u2013612 (2015).","journal-title":"Immunity"},{"key":"1508_CR24","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/350423a0","volume":"350","author":"D Kitamura","year":"1991","unstructured":"Kitamura, D., Roes, J., Kuhn, R. & Rajewsky, K. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin \u00b5 chain gene. Nature 350, 423\u2013426 (1991).","journal-title":"Nature"},{"key":"1508_CR25","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1038\/s41556-019-0373-7","volume":"21","author":"IS Kim","year":"2019","unstructured":"Kim, I. S. et al. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nat. Cell Biol. 21, 1113\u20131126 (2019).","journal-title":"Nat. Cell Biol."},{"key":"1508_CR26","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/0092-8674(92)90030-G","volume":"68","author":"P Mombaerts","year":"1992","unstructured":"Mombaerts, P. et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869\u2013877 (1992).","journal-title":"Cell"},{"key":"1508_CR27","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nri3862","volume":"15","author":"EJ Wherry","year":"2015","unstructured":"Wherry, E. J. & Kurachi, M. Molecular and cellular insights into T cell exhaustion. Nat. Rev. Immunol. 15, 486\u2013499 (2015).","journal-title":"Nat. Rev. Immunol."},{"key":"1508_CR28","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1158\/2326-6066.CIR-15-0097","volume":"3","author":"DS Thommen","year":"2015","unstructured":"Thommen, D. S. et al. Progression of lung cancer is associated with increased dysfunction of T cells defined by coexpression of multiple inhibitory receptors. Cancer Immunol. Res 3, 1344\u20131355 (2015).","journal-title":"Cancer Immunol. Res"},{"key":"1508_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10501","volume":"7","author":"S Koyama","year":"2016","unstructured":"Koyama, S. et al. Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. Nat. Commun. 7, 10501 (2016).","journal-title":"Nat. Commun."},{"key":"1508_CR30","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/s41423-023-01118-6","volume":"21","author":"Y Li","year":"2024","unstructured":"Li, Y. et al. Id2 epigenetically controls CD8+ T-cell exhaustion by disrupting the assembly of the Tcf3\u2013LSD1 complex. Cell Mol. Immunol. 21, 292\u2013308 (2024).","journal-title":"Cell Mol. Immunol."},{"key":"1508_CR31","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/s41590-019-0312-6","volume":"20","author":"BC Miller","year":"2019","unstructured":"Miller, B. C. et al. Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade. Nat. Immunol. 20, 326\u2013336 (2019).","journal-title":"Nat. Immunol."},{"key":"1508_CR32","doi-asserted-by":"publisher","unstructured":"Markowitz, G. J. et al. Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival. JCI Insight https:\/\/doi.org\/10.1172\/jci.insight.96836 (2018).","DOI":"10.1172\/jci.insight.96836"},{"key":"1508_CR33","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nature19317","volume":"537","author":"R He","year":"2016","unstructured":"He, R. et al. Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection. Nature 537, 412\u2013428 (2016).","journal-title":"Nature"},{"key":"1508_CR34","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","volume":"17","author":"R Browaeys","year":"2020","unstructured":"Browaeys, R., Saelens, W. & Saeys, Y. NicheNet: modeling intercellular communication by linking ligands to target genes. Nat. Methods 17, 159\u2013162 (2020).","journal-title":"Nat. Methods"},{"key":"1508_CR35","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/intimm\/dxs051","volume":"24","author":"CA Wild","year":"2012","unstructured":"Wild, C. A. et al. HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells. Int. Immunol. 24, 485\u2013494 (2012).","journal-title":"Int. Immunol."},{"key":"1508_CR36","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1084\/jem.180.5.1937","volume":"180","author":"JD Gray","year":"1994","unstructured":"Gray, J. D., Hirokawa, M. & Horwitz, D. A. The role of transforming growth factor beta in the generation of suppression: an interaction between CD8+ T and NK cells. J. Exp. Med. 180, 1937\u20131942 (1994).","journal-title":"J. Exp. Med."},{"key":"1508_CR37","doi-asserted-by":"publisher","unstructured":"Hubert, P. et al. Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy. J. Immunother. Cancer https:\/\/doi.org\/10.1136\/jitc-2020-001966 (2021).","DOI":"10.1136\/jitc-2020-001966"},{"key":"1508_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-11-69","volume":"11","author":"S Sundaramoorthy","year":"2013","unstructured":"Sundaramoorthy, S., Ryu, M. S. & Lim, I. K. B-cell translocation gene 2 mediates crosstalk between PI3K\/Akt1 and NF-\u03baB pathways which enhances transcription of MnSOD by accelerating I\u03baB\u03b1 degradation in normal and cancer cells. Cell Commun. Signal 11, 69 (2013).","journal-title":"Cell Commun. Signal"},{"key":"1508_CR39","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.bbagrm.2010.05.004","volume":"1799","author":"SC Gupta","year":"2010","unstructured":"Gupta, S. C., Sundaram, C., Reuter, S. & Aggarwal, B. B. Inhibiting NF-\u03baB activation by small molecules as a therapeutic strategy. Biochim. Biophys. Acta 1799, 775\u2013787 (2010).","journal-title":"Biochim. Biophys. Acta"},{"key":"1508_CR40","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000182","volume":"2","author":"S Gerondakis","year":"2010","unstructured":"Gerondakis, S. & Siebenlist, U. Roles of the NF-\u03baB pathway in lymphocyte development and function. Cold Spring Harb. Perspect. Biol. 2, a000182 (2010).","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"1508_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1476-9433-3-1","volume":"3","author":"B Feng","year":"2004","unstructured":"Feng, B., Cheng, S., Pear, W. S. & Liou, H. C. NF-kB inhibitor blocks B cell development at two checkpoints. Med. Immunol. 3, 1 (2004).","journal-title":"Med. Immunol."},{"key":"1508_CR42","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nri844","volume":"2","author":"F Mackay","year":"2002","unstructured":"Mackay, F. & Browning, J. L. BAFF: a fundamental survival factor for B cells. Nat. Rev. Immunol. 2, 465\u2013475 (2002).","journal-title":"Nat. Rev. Immunol."},{"key":"1508_CR43","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.1182\/blood.V92.12.4828","volume":"92","author":"PP McDonald","year":"1998","unstructured":"McDonald, P. P., Russo, M. P., Ferrini, S. & Cassatella, M. A. Interleukin-15 (IL-15) induces NF-\u03baB activation and IL-8 production in human neutrophils. Blood 92, 4828\u20134835 (1998).","journal-title":"Blood"},{"key":"1508_CR44","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.4049\/jimmunol.1301815","volume":"192","author":"H Kraus","year":"2014","unstructured":"Kraus, H. et al. A feeder-free differentiation system identifies autonomously proliferating B cell precursors in human bone marrow. J. Immunol. 192, 1044\u20131054 (2014).","journal-title":"J. Immunol."},{"key":"1508_CR45","doi-asserted-by":"publisher","first-page":"264","DOI":"10.7555\/JBR.29.20150035","volume":"29","author":"M Bemark","year":"2015","unstructured":"Bemark, M. Translating transitions\u2014how to decipher peripheral human B cell development. J. Biomed. Res 29, 264\u2013284 (2015).","journal-title":"J. Biomed. Res"},{"key":"1508_CR46","doi-asserted-by":"publisher","first-page":"4290","DOI":"10.1158\/0008-5472.CAN-20-3773","volume":"81","author":"RJ Harris","year":"2021","unstructured":"Harris, R. J. et al. Tumor-infiltrating B lymphocyte profiling identifies IgG-biased, clonally expanded prognostic phenotypes in triple-negative breast cancer. Cancer Res. 81, 4290\u20134304 (2021).","journal-title":"Cancer Res."},{"key":"1508_CR47","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","volume":"177","author":"T Stuart","year":"2019","unstructured":"Stuart, T. et al. Comprehensive integration of single-cell data. Cell 177, 1888\u20131902 e1821 (2019).","journal-title":"Cell"},{"key":"1508_CR48","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1874-1","volume":"20","author":"C Hafemeister","year":"2019","unstructured":"Hafemeister, C. & Satija, R. Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Genome Biol. 20, 296 (2019).","journal-title":"Genome Biol."},{"key":"1508_CR49","first-page":"100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu, T. et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation 2, 100141 (2021).","journal-title":"Innovation"},{"key":"1508_CR50","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu, G., Wang, L.-G., Han, Y. & He, Q.-Y. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS: A J. Integr. Biol. 16, 284\u2013287 (2012).","journal-title":"OMICS: A J. Integr. Biol."}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41556-024-01508-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41556-024-01508-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41556-024-01508-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T18:05:40Z","timestamp":1731693940000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41556-024-01508-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["1508"],"URL":"https:\/\/doi.org\/10.1038\/s41556-024-01508-6","relation":{},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,12]]},"assertion":[{"value":"23 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}