{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:10:46Z","timestamp":1792789846134,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["106244\/Z\/14\/Z"],"award-info":[{"award-number":["106244\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat. Chem."],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1038\/s41557-021-00831-x","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T17:47:34Z","timestamp":1639417654000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Imitation of \u03b2-lactam binding enables broad-spectrum metallo-\u03b2-lactamase inhibitors"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0137-3226","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Brem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-1336","authenticated-orcid":false,"given":"Tharindi","family":"Panduwawala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon Ulf","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Hewitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgars","family":"Liepins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4358-2429","authenticated-orcid":false,"given":"Pawel","family":"Donets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Espina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair J. M.","family":"Farley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill","family":"Shubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2405-8421","authenticated-orcid":false,"given":"Gonzalo Gomez","family":"Campillos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6084-684X","authenticated-orcid":false,"given":"Paula","family":"Kiuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-3877","authenticated-orcid":false,"given":"Shifali","family":"Shishodia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Krahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Le\u015bniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Calvopi\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Carmen","family":"Turrientes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4735-1559","authenticated-orcid":false,"given":"Madeline E.","family":"Kavanagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8014-4172","authenticated-orcid":false,"given":"Dmitrijs","family":"Lubriks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Hinchliffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-3712","authenticated-orcid":false,"given":"Gareth W.","family":"Langley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali F.","family":"Aboklaish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Eneroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6253-816X","authenticated-orcid":false,"given":"Maria","family":"Backlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei G.","family":"Baran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0725-214X","authenticated-orcid":false,"given":"Elisabet I.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Speake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis","family":"Kuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solveiga","family":"Grinberga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4664-6942","authenticated-orcid":false,"given":"Michael A.","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Rydzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Leissing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Jimenez-Castellanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Avison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange","family":"Da Silva Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Pannifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Martjuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6721-8643","authenticated-orcid":false,"given":"Emma","family":"Widlake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9655-8345","authenticated-orcid":false,"given":"Martins","family":"Priede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Hopkins Navratilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Gniadkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6257-4064","authenticated-orcid":false,"given":"Anna Karin","family":"Belfrage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2885-2016","authenticated-orcid":false,"given":"Peter","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0370-7653","authenticated-orcid":false,"given":"Jari","family":"Yli-Kauhaluoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bacque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-8174","authenticated-orcid":false,"given":"Malcolm G. P.","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7018-8334","authenticated-orcid":false,"given":"Fredrik","family":"Bj\u00f6rkling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Tyrrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4602-0571","authenticated-orcid":false,"given":"James","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3187-1469","authenticated-orcid":false,"given":"Pauline A.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-6791","authenticated-orcid":false,"given":"Pawel","family":"Baranczewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-3173","authenticated-orcid":false,"given":"Rafael","family":"Cant\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart P.","family":"McElroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Baquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3078-0576","authenticated-orcid":false,"given":"Edgars","family":"Suna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0290-6565","authenticated-orcid":false,"given":"Christopher J.","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"831_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/jac\/dkl483","volume":"59","author":"DM Livermore","year":"2007","unstructured":"Livermore, D. M. et al. CTX-M: changing the face of ESBLs in Europe. J. Antimicrob. Chemother. 59, 165\u2013174 (2007).","journal-title":"J. Antimicrob. Chemother."},{"key":"831_CR2","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S1473-3099(10)70143-2","volume":"10","author":"KK Kumarasamy","year":"2010","unstructured":"Kumarasamy, K. K. et al. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 10, 597\u2013602 (2010).","journal-title":"Lancet Infect. Dis."},{"key":"831_CR3","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","volume":"16","author":"YY Liu","year":"2016","unstructured":"Liu, Y. Y. et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect. Dis. 16, 161\u2013168 (2016).","journal-title":"Lancet Infect. Dis."},{"key":"831_CR4","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1038\/s41564-019-0445-2","volume":"4","author":"T He","year":"2019","unstructured":"He, T. et al. Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans. Nat. Microbiol. 4, 1450\u20131456 (2019).","journal-title":"Nat. Microbiol."},{"key":"831_CR5","doi-asserted-by":"publisher","first-page":"e00115-20","DOI":"10.1128\/CMR.00115-20","volume":"34","author":"D Yahav","year":"2020","unstructured":"Yahav, D. et al. New \u03b2-lactam-\u03b2-lactamase inhibitor combinations. Clin. Microbiol. Rev. 34, e00115-20 (2020).","journal-title":"Clin. Microbiol. Rev."},{"key":"831_CR6","doi-asserted-by":"publisher","first-page":"e01076-18","DOI":"10.1128\/AAC.01076-18","volume":"62","author":"K Bush","year":"2018","unstructured":"Bush, K. Past and present perspectives on \u03b2-lactamases. Antimicrob. Agents Chemother. 62, e01076-18 (2018).","journal-title":"Antimicrob. Agents Chemother."},{"key":"831_CR7","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.mib.2017.10.026","volume":"39","author":"CM Rotondo","year":"2017","unstructured":"Rotondo, C. M. & Wright, G. D. Inhibitors of metallo-\u03b2-lactamases. Curr. Opin. Microbiol. 39, 96\u2013105 (2017).","journal-title":"Curr. Opin. Microbiol."},{"key":"831_CR8","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1093\/cid\/cix893","volume":"66","author":"RA Bonomo","year":"2018","unstructured":"Bonomo, R. A. et al. Carbapenemase-producing organisms: a global scourge. Clin. Infect. Dis. 66, 1290\u20131297 (2018).","journal-title":"Clin. Infect. Dis."},{"key":"831_CR9","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.4155\/fmc-2016-0078","volume":"8","author":"DY Wang","year":"2016","unstructured":"Wang, D. Y., Abboud, M. I., Markoulides, M. S., Brem, J. & Schofield, C. J. The road to avibactam: the first clinically useful non-\u03b2-lactam working somewhat like a \u03b2-lactam. Future Med. Chem. 8, 1063\u20131084 (2016).","journal-title":"Future Med. Chem."},{"key":"831_CR10","doi-asserted-by":"publisher","first-page":"11663","DOI":"10.1073\/pnas.1205073109","volume":"109","author":"DE Ehmann","year":"2012","unstructured":"Ehmann, D. E. et al. Avibactam is a covalent, reversible, non-\u03b2-lactam \u03b2-lactamase inhibitor. Proc. Natl Acad. Sci. USA 109, 11663\u201311668 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"831_CR11","doi-asserted-by":"publisher","first-page":"e01443-17","DOI":"10.1128\/AAC.01443-17","volume":"61","author":"O Lomovskaya","year":"2017","unstructured":"Lomovskaya, O. et al. Vaborbactam: spectrum of \u03b2-lactamase inhibition and impact of resistance mechanisms on activity in Enterobacteriaceae. Antimicrob. Agents Chemother. 61, e01443-17 (2017).","journal-title":"Antimicrob. Agents Chemother."},{"key":"831_CR12","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1016\/j.bmcl.2019.05.031","volume":"29","author":"GW Langley","year":"2019","unstructured":"Langley, G. W. et al. Profiling interactions of vaborbactam with metallo-\u03b2-lactamases. Bioorg. Med. Chem. Lett. 29, 1981\u20131984 (2019).","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"831_CR13","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.idc.2020.05.001","volume":"34","author":"KM Papp-Wallace","year":"2020","unstructured":"Papp-Wallace, K. M., Mack, A. R., Taracila, M. A. & Bonomo, R. A. Resistance to novel \u03b2-lactam-\u03b2-lactamase inhibitor combinations: the \u2018price of progress\u2019. Infect. Dis. Clin. North Am. 34, 773\u2013819 (2020).","journal-title":"Infect. Dis. Clin. North Am."},{"key":"831_CR14","doi-asserted-by":"publisher","first-page":"e01224-17","DOI":"10.1128\/AAC.01224-17","volume":"61","author":"CT Lohans","year":"2017","unstructured":"Lohans, C. T., Brem, J. & Schofield, C. J. New Delhi metallo-\u03b2-lactamase 1 catalyzes avibactam and aztreonam hydrolysis. Antimicrob. Agents Chemother. 61, e01224-17 (2017).","journal-title":"Antimicrob. Agents Chemother."},{"key":"831_CR15","doi-asserted-by":"publisher","first-page":"3419","DOI":"10.1016\/j.febslet.2015.08.015","volume":"589","author":"MR Meini","year":"2015","unstructured":"Meini, M. R., Llarrull, L. I. & Vila, A. J. Overcoming differences: the catalytic mechanism of metallo-\u03b2-lactamases. FEBS Lett. 589, 3419\u20133432 (2015).","journal-title":"FEBS Lett."},{"key":"831_CR16","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1128\/CMR.00037-09","volume":"23","author":"SM Drawz","year":"2010","unstructured":"Drawz, S. M. & Bonomo, R. A. Three decades of \u03b2-lactamase inhibitors. Clin. Microbiol. Rev. 23, 160\u2013201 (2010).","journal-title":"Clin. Microbiol. Rev."},{"key":"831_CR17","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1021\/acsinfecdis.0c00207","volume":"6","author":"DT Davies","year":"2020","unstructured":"Davies, D. T. et al. ANT2681: SAR studies leading to the identification of a metallo-\u03b2-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-producing Enterobacteriaceae. ACS Infect. Dis. 6, 2419\u20132430 (2020).","journal-title":"ACS Infect. Dis."},{"key":"831_CR18","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/nature13445","volume":"510","author":"AM King","year":"2014","unstructured":"King, A. M. et al. Aspergillomarasmine A overcomes metallo-\u03b2-lactamase antibiotic resistance. Nature 510, 503\u2013506 (2014).","journal-title":"Nature"},{"key":"831_CR19","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1021\/acs.jmedchem.9b01518","volume":"63","author":"B Liu","year":"2020","unstructured":"Liu, B. et al. Discovery of taniborbactam (VNRX-5133): a broad-spectrum serine- and metallo-\u03b2-lactamase inhibitor for carbapenem-resistant bacterial infections. J. Med. Chem. 63, 2789\u20132801 (2020).","journal-title":"J. Med. Chem."},{"key":"831_CR20","doi-asserted-by":"publisher","first-page":"e00047-19","DOI":"10.1128\/CMR.00047-19","volume":"33","author":"K Bush","year":"2020","unstructured":"Bush, K. & Bradford, P. A. Epidemiology of \u03b2-lactamase-producing pathogens. Clin. Microbiol. Rev. 33, e00047-19 (2020).","journal-title":"Clin. Microbiol. Rev."},{"key":"831_CR21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/antibiotics5010012","volume":"5","author":"E Sauvage","year":"2016","unstructured":"Sauvage, E. & Terrak, M. Glycosyltransferases and transpeptidases\/penicillin-binding proteins: valuable targets for new antibacterials. Antibiotics 5, 12 (2016).","journal-title":"Antibiotics"},{"key":"831_CR22","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s41579-019-0159-8","volume":"17","author":"K Bush","year":"2019","unstructured":"Bush, K. & Bradford, P. A. Interplay between \u03b2-lactamases and new \u03b2-lactamase inhibitors. Nat. Rev. Microbiol. 17, 295\u2013306 (2019).","journal-title":"Nat. Rev. Microbiol."},{"key":"831_CR23","doi-asserted-by":"publisher","first-page":"5952","DOI":"10.1021\/acs.chemrev.8b00277","volume":"118","author":"DA Dik","year":"2018","unstructured":"Dik, D. A., Fisher, J. F. & Mobashery, S. Cell-wall recycling of the Gram-negative bacteria and the nexus to antibiotic resistance. Chem. Rev. 118, 5952\u20135984 (2018).","journal-title":"Chem. Rev."},{"key":"831_CR24","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1073\/pnas.54.4.1133","volume":"54","author":"DJ Tipper","year":"1965","unstructured":"Tipper, D. J. & Strominger, J. L. Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-d-alanyl-d-alanine. Proc. Natl Acad. Sci. USA 54, 1133\u20131141 (1965).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"831_CR25","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3389\/fmed.2016.00075","volume":"3","author":"A Karawajczyk","year":"2017","unstructured":"Karawajczyk, A., Orling, K. M., de Vlieger, J. S. B., Rijnders, T. & Tzalis, D. The European Lead Factory: a blueprint for public\u2013private partnerships in early drug discovery. Front. Med. 3, 75 (2017).","journal-title":"Front. Med."},{"key":"831_CR26","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.drudis.2014.08.014","volume":"20","author":"J Besnard","year":"2015","unstructured":"Besnard, J., Jones, P. S., Hopkins, A. L. & Pannifer, A. D. The Joint European Compound Library: boosting precompetitive research. Drug Discov. Today 20, 181\u2013186 (2015).","journal-title":"Drug Discov. Today"},{"key":"831_CR27","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1002\/med.21665","volume":"40","author":"YH Yan","year":"2020","unstructured":"Yan, Y. H., Li, G. & Li, G. B. Principles and current strategies targeting metallo-\u03b2-lactamase mediated antibacterial resistance. Med. Res. Rev. 40, 1558\u20131592 (2020).","journal-title":"Med. Res. Rev."},{"key":"831_CR28","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.tips.2018.03.007","volume":"39","author":"LC Ju","year":"2018","unstructured":"Ju, L. C., Cheng, Z., Fast, W., Bonomo, R. A. & Crowder, M. W. The continuing challenge of metallo-\u03b2-lactamase inhibition: mechanism matters. Trends Pharmacol. Sci. 39, 635\u2013647 (2018).","journal-title":"Trends Pharmacol. Sci."},{"key":"831_CR29","unstructured":"Brem J., et al. Inhibitors of metallo-beta-lactamases. World Patent WO2017093727A1 (2017)."},{"key":"831_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49264-0","volume":"9","author":"CT Lohans","year":"2019","unstructured":"Lohans, C. T. et al. Mechanistic Insights into \u03b2-lactamase-catalysed carbapenem degradation through product characterisation. Sci. Rep. 9, 13608 (2019).","journal-title":"Sci. Rep."},{"key":"831_CR31","doi-asserted-by":"publisher","first-page":"11362","DOI":"10.1021\/ja303579d","volume":"134","author":"DT King","year":"2012","unstructured":"King, D. T., Worrall, L. J., Gruninger, R. & Strynadka, N. C. J. New Delhi metallo-\u03b2-lactamase: structural insights into \u03b2-lactam recognition and inhibition. J. Am. Chem. Soc. 134, 11362\u201311365 (2012).","journal-title":"J. Am. Chem. Soc."},{"key":"831_CR32","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1038\/s41467-017-02339-w","volume":"8","author":"H Feng","year":"2017","unstructured":"Feng, H. et al. The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis. Nat. Commun. 8, 2242 (2017).","journal-title":"Nat. Commun."},{"key":"831_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.drup.2018.08.001","volume":"40","author":"JE Raczynska","year":"2018","unstructured":"Raczynska, J. E., Shabalin, I. G., Minor, W., Wlodawer, A. & Jaskolski, M. A close look onto structural models and primary ligands of metallo-\u03b2-lactamases. Drug Resist. Update 40, 1\u201312 (2018).","journal-title":"Drug Resist. Update"},{"key":"831_CR34","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.bbagen.2019.02.004","volume":"1863","author":"ST Cahill","year":"2019","unstructured":"Cahill, S. T. et al. Studies on the inhibition of AmpC and other \u03b2-lactamases by cyclic boronates. Biochim. Biophys. Acta Gen. Subj. 1863, 742\u2013748 (2019).","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"831_CR35","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1093\/jac\/dkx345","volume":"73","author":"J-C Jim\u00e9nez-Castellanos","year":"2017","unstructured":"Jim\u00e9nez-Castellanos, J.-C. et al. Envelope proteome changes driven by RamA overproduction in Klebsiella pneumoniae that enhance acquired \u03b2-lactam resistance. J. Antimic. Chemother. 73, 88\u201394 (2017).","journal-title":"J. Antimic. Chemother."},{"key":"831_CR36","doi-asserted-by":"publisher","first-page":"8544","DOI":"10.1021\/acs.jmedchem.9b00911","volume":"62","author":"A Krajnc","year":"2019","unstructured":"Krajnc, A. et al. Bicyclic boronate VNRX-5133 inhibits metallo- and serine-\u03b2-lactamases. J. Med. Chem. 62, 8544\u20138556 (2019).","journal-title":"J. Med. Chem."},{"key":"831_CR37","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/s41467-017-00601-9","volume":"8","author":"M-N Lisa","year":"2017","unstructured":"Lisa, M.-N. et al. A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-\u03b2-lactamases. Nat. Comm. 8, 538 (2017).","journal-title":"Nat. Comm."},{"key":"831_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12406","volume":"7","author":"J Brem","year":"2016","unstructured":"Brem, J. et al. Structural basis of metallo-\u03b2-lactamase, serine-\u03b2-lactamase and penicillin-binding protein inhibition by cyclic boronates. Nat. Commun. 7, 12406 (2016).","journal-title":"Nat. Commun."},{"key":"831_CR39","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nature22308","volume":"545","author":"MF Richter","year":"2017","unstructured":"Richter, M. F. et al. Predictive compound accumulation rules yield a broad-spectrum antibiotic. Nature 545, 299\u2013304 (2017).","journal-title":"Nature"},{"key":"831_CR40","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1128\/AAC.47.8.2551-2557.2003","volume":"47","author":"J-C Gal\u00e1n","year":"2003","unstructured":"Gal\u00e1n, J.-C., Morosini, M.-I., Baquero, M.-R., Reig, M. & Baquero, F. Haemophilus influenzae bla(ROB-1) mutations in hypermutagenic \u0394ampC Escherichia coli conferring resistance to cefotaxime and \u03b2-lactamase inhibitors and increased susceptibility to cefaclor. Antimic. Agents Chemother. 47, 2551\u20132557 (2003).","journal-title":"Antimic. Agents Chemother."},{"key":"831_CR41","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/s41579-020-0340-0","volume":"18","author":"U Theuretzbacher","year":"2020","unstructured":"Theuretzbacher, U. et al. Critical analysis of antibacterial agents in clinical development. Nat. Rev. Microbiol. 18, 286\u2013298 (2020).","journal-title":"Nat. Rev. Microbiol."},{"key":"831_CR42","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.2174\/1389450116666151001105622","volume":"17","author":"MF Mojica","year":"2016","unstructured":"Mojica, M. F., Bonomo, R. A. & Fast, W. B1-metallo-\u03b2-lactamases: where do we stand? Curr. Drug Targets 17, 1029\u20131050 (2016).","journal-title":"Curr. Drug Targets"},{"key":"831_CR43","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1128\/AAC.01335-15","volume":"60","author":"J Brem","year":"2015","unstructured":"Brem, J. et al. Structural basis of metallo-4-lactamase inhibition by captopril stereoisomers. Antimic. Agents Chemother. 60, 142\u2013150 (2015).","journal-title":"Antimic. Agents Chemother."},{"key":"831_CR44","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/nchem.2110","volume":"6","author":"J Brem","year":"2014","unstructured":"Brem, J. et al. Rhodanine hydrolysis leads to potent thioenolate mediated metallo-\u03b2-lactamase inhibition. Nat. Chem. 6, 1084\u20131090 (2014).","journal-title":"Nat. Chem."},{"key":"831_CR45","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.tibs.2015.12.007","volume":"41","author":"I Pettinati","year":"2016","unstructured":"Pettinati, I., Brem, J., Lee, S. Y., McHugh, P. J. & Schofield, C. J. The chemical biology of human metallo-\u03b2-lactamase fold proteins. Trends Biochem. Sci 41, 338\u2013355 (2016).","journal-title":"Trends Biochem. Sci"},{"key":"831_CR46","doi-asserted-by":"publisher","first-page":"iii25","DOI":"10.1093\/jac\/dkq298","volume":"65","author":"A Pallett","year":"2010","unstructured":"Pallett, A. & Hand, K. Complicated urinary tract infections: practical solutions for the treatment of multiresistant Gram-negative bacteria. J. Antimicrob. Chemother. 65, iii25\u2013iii33 (2010).","journal-title":"J. Antimicrob. Chemother."}],"container-title":["Nature Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41557-021-00831-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41557-021-00831-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41557-021-00831-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T09:32:03Z","timestamp":1676021523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41557-021-00831-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,13]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["831"],"URL":"https:\/\/doi.org\/10.1038\/s41557-021-00831-x","relation":{},"ISSN":["1755-4330","1755-4349"],"issn-type":[{"value":"1755-4330","type":"print"},{"value":"1755-4349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,13]]},"assertion":[{"value":"12 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A patent has been filed concerning the indole carboxylates as MBL inhibitors (WO2017093727A1)<sup>29<\/sup>. The inventors may benefit financially from the work. The work described in the manuscript was carried out prior to these employments, which are not relevant to the work. G.W.L. is an employee of Charles River Laboratories, M.S., J.R., L.R., S.P.M., P.S.J. and A.M. are employees of BioAscent Discovery Ltd, A.M.R. is an employee of AstraZeneca and E.B. is an employee of Evotec.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}