{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:33:18Z","timestamp":1789435998797,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21871033"],"award-info":[{"award-number":["21871033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22271033"],"award-info":[{"award-number":["22271033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["CSTB2022NSCQLZX0036"],"award-info":[{"award-number":["CSTB2022NSCQLZX0036"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat. Chem."],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1038\/s41557-023-01264-4","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T12:02:10Z","timestamp":1687780930000},"page":"1074-1082","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["A bridged backbone strategy enables collective synthesis of strychnan alkaloids"],"prefix":"10.1038","volume":"15","author":[{"given":"Wenqiang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyue","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2328-0020","authenticated-orcid":false,"given":"Yu","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-7836","authenticated-orcid":false,"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"1264_CR1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","volume":"20","author":"AG Atanasov","year":"2021","unstructured":"Atanasov, A. G., Zotchev, S. B., Dirsch, V. M., the International Natural Product Sciences Taskforce, & Supuran, C. T. Natural products in drug discovery: advances and opportunities. Nat. Rev. Drug Discovery 20, 200\u2013216 2021).","journal-title":"Nat. Rev. Drug Discovery"},{"key":"1264_CR2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nchem.2479","volume":"8","author":"T Rodrigues","year":"2016","unstructured":"Rodrigues, T., Reker, D., Schneider, P. & Schneider, G. Counting on natural products for drug design. Nat. Chem. 8, 531\u2013541 (2016).","journal-title":"Nat. Chem."},{"key":"1264_CR3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","volume":"83","author":"DJ Newman","year":"2020","unstructured":"Newman, D. J. & Cragg, G. M. Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019. J. Nat. Prod. 83, 770\u2013803 (2020).","journal-title":"J. Nat. Prod."},{"key":"1264_CR4","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1021\/acs.jcim.0c00890","volume":"61","author":"A Ricarte","year":"2021","unstructured":"Ricarte, A., Dalton, J. A. R. & Giraldo, J. Structural assessment of agonist efficacy in the \u03bc\u2011opioid receptor: morphine and fentanyl elicit different activation patterns. J. Chem. Inf. Model. 61, 1251\u20131274 (2021).","journal-title":"J. Chem. Inf. Model."},{"key":"1264_CR5","doi-asserted-by":"crossref","unstructured":"Zhao, S., Sirasani, G. & Andrade, R. B. in The Alkaloids: Chemistry and Biology Vol. 86 (ed. Kn\u00f6lker, H. J.) 1\u2212143 (Academic Press, 2021).","DOI":"10.1016\/bs.alkal.2021.05.001"},{"key":"1264_CR6","doi-asserted-by":"crossref","unstructured":"Sirasani, G. & Andrade, R. B. in Strategies and Tactics in Organic Synthesis Vol. 9 (ed. Harmata, M.) Ch. 1 (Academic Press, 2013).","DOI":"10.1016\/B978-0-08-099362-1.00001-1"},{"key":"1264_CR7","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1039\/C9OB02627D","volume":"18","author":"W He","year":"2020","unstructured":"He, W., Wang, P., Chen, J. & Xie, W. Recent progress in the total synthesis of Strychnos alkaloids. Org. Biomol. Chem. 18, 1046\u20131056 (2020).","journal-title":"Org. Biomol. Chem."},{"key":"1264_CR8","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1002\/anie.201107385","volume":"51","author":"JS Cannon","year":"2012","unstructured":"Cannon, J. S. & Overman, L. E. Is there no end to the total syntheses of strychnine? Lessons learned in strategy and tactics in total synthesis. Angew. Chem. Int. Ed. 51, 4288\u20134311 (2012).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1264_CR9","doi-asserted-by":"crossref","unstructured":"Krause, N., Stephen, A. & Hashmi, K. Modern Allene Chemistry (Wiley, 2004).","DOI":"10.1002\/9783527619573"},{"key":"1264_CR10","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1002\/anie.201101460","volume":"51","author":"S Yu","year":"2012","unstructured":"Yu, S. & Ma, S. Allenes in catalytic asymmetric synthesis and natural product syntheses. Angew. Chem. Int. Ed. 51, 3074\u20133112 (2012).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1264_CR11","unstructured":"Watson, A. & MacMillan, D. in Science of Synthesis: Stereoselective Synthesis 3; Stereoselective Pericyclic Reactions Cross-coupling, and C\u2212H and C\u2212X Activation (ed. Evans, P. A.) 675\u2013745 (Stuttgart, 2011)."},{"key":"1264_CR12","doi-asserted-by":"crossref","first-page":"11579","DOI":"10.1002\/anie.201404643","volume":"53","author":"Y Liu","year":"2014","unstructured":"Liu, Y. et al. Nickel(II)-catalyzed asymmetric propargyl and allyl claisen rearrangements to allenyl- and allyl-substituted \u03b2-ketoesters. Angew. Chem. Int. Ed. 53, 11579\u201311582 (2014).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1264_CR13","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1002\/anie.201107417","volume":"51","author":"T Cao","year":"2012","unstructured":"Cao, T., Deitch, J., Linton, E. C. & Kozlowski, M. C. Asymmetric synthesis of allenyl oxindoles and spirooxindoles by a catalytic enantioselective Saucy\u2013Marbet Claisen rearrangement. Angew. Chem. Int. Ed. 51, 2448\u20132451 (2012).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1264_CR14","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41467-017-00251-x","volume":"8","author":"D Qian","year":"2017","unstructured":"Qian, D., Wu, L., Lin, Z. & Sun, J. Organocatalytic synthesis of chiral tetrasubstituted allenes from racemic propargylic alcohols. Nat. Commun. 8, 567 (2017).","journal-title":"Nat. Commun."},{"key":"1264_CR15","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1021\/acs.orglett.2c00179","volume":"24","author":"HJ Loui","year":"2022","unstructured":"Loui, H. J. & Schneider, C. Cooperative palladium\/Br\u00f8nsted acid catalysis toward the highly enantioselective allenylation of \u03b2-keto esters. Org. Lett. 24, 1496\u20131501 (2022).","journal-title":"Org. Lett."},{"key":"1264_CR16","doi-asserted-by":"crossref","unstructured":"J. Zhou, Ed. Multicatalyst System in Asymmetric Catalysis (Wiley, 2014).","DOI":"10.1002\/9781118846919"},{"key":"1264_CR17","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1039\/c2sc00907b","volume":"3","author":"AE Allen","year":"2012","unstructured":"Allen, A. E. & Macmillan, D. W. C. Synergistic catalysis: a powerful synthetic strategy for new reaction development. Chem. Sci. 3, 633\u2013658 (2012).","journal-title":"Chem. Sci."},{"key":"1264_CR18","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1055\/s-0030-1258420","volume":"7","author":"J Bonjoch","year":"2011","unstructured":"Bonjoch, J., Diaba, F. & Bradshaw, B. Synthesis of 2-azabicyclo[3.3.1]nonanes. Synthesis 7, 993\u20131018 (2011).","journal-title":"Synthesis"},{"key":"1264_CR19","doi-asserted-by":"crossref","first-page":"16252","DOI":"10.1002\/anie.201908495","volume":"58","author":"Y Xu","year":"2019","unstructured":"Xu, Y. et al. Organocatalytic enantioselective Conia-ene-type carbocyclization of ynamide cyclohexanones: regiodivergent synthesis of morphans and normorphans. Angew. Chem. Int. Ed. 58, 16252\u201316259 (2019).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1264_CR20","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.1002\/anie.201612048","volume":"56","author":"R Manzano","year":"2017","unstructured":"Manzano, R., Datta, S., Paton, R. S. & Dixon, D. J. Enantioselective silver and amine co-catalyzed desymmetrizing cycloisomerization of alkyne-linked cyclohexanones. Angew. Chem. Int. Ed. 56, 5834\u20135838 (2017).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1264_CR21","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1021\/jacs.6b01214","volume":"138","author":"R Liu","year":"2016","unstructured":"Liu, R. et al. Palladium\/L\u2011proline-catalyzed enantioselective \u03b1\u2011arylative desymmetrization of cyclohexanones. J. Am. Chem. Soc. 138, 5198\u20135201 (2016).","journal-title":"J. Am. Chem. Soc."},{"key":"1264_CR22","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1002\/anie.201411924","volume":"54","author":"AD Gammack Yamagata","year":"2015","unstructured":"Gammack Yamagata, A. D. et al. Enantioselective desymmetrization of prochiral cyclohexanones by organocatalytic intramolecular michael additions to \u03b1,\u03b2-unsaturated esters. Angew. Chem. Int. Ed. 54, 4899\u20134903 (2015).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1264_CR23","unstructured":"Frisch, M. J. et al. Gaussian 09, Revision D.01 (Gaussian, Inc., 2013)."},{"key":"1264_CR24","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","volume":"98","author":"AD Becke","year":"1993","unstructured":"Becke, A. D. Density-functional thermochemistry. III. The role of exact exchange. J. Chem. Phys. 98, 5648\u20135652 (1993).","journal-title":"J. Chem. Phys."},{"key":"1264_CR25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","volume":"37","author":"C Lee","year":"1988","unstructured":"Lee, C., Yang, W. & Parr, R. G. Development of the Colle\u2013Salvetti correlation-energy formula into a functional of the electron density. Phys. Rev. B. 37, 785\u2013789 (1988).","journal-title":"Phys. Rev. B."},{"key":"1264_CR26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00214-007-0310-x","volume":"120","author":"Y Zhao","year":"2008","unstructured":"Zhao, Y. & Truhlar, D. G. The Mo6 suite of density functionals for main group thermochemistry, thermochemical kinetics, noncovalent interactions, excited states, and transition elements: two new functionals and systematic testing of four Mo6-class functionals and 12 other functionals. Theor. Chem. Acc. 120, 215\u2013241 (2008).","journal-title":"Theor. Chem. Acc."},{"key":"1264_CR27","doi-asserted-by":"crossref","first-page":"17556","DOI":"10.1002\/anie.202005151","volume":"59","author":"LS Hutchings-Goetz","year":"2020","unstructured":"Hutchings-Goetz, L. S., Yang, C., Fyfe, J. W. B. & Snaddon, T. N. Enantioselective syntheses of Strychnos and Chelidonium alkaloids through regio- and stereocontrolled cooperative catalysis. Angew. Chem. Int. Ed. 59, 17556\u201317564 (2020).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1264_CR28","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1021\/acs.orglett.8b03686","volume":"21","author":"L He","year":"2019","unstructured":"He, L. et al. Asymmetric total synthesis of (+)-strychnine. Org. Lett. 21, 252\u2013255 (2019).","journal-title":"Org. Lett."},{"key":"1264_CR29","doi-asserted-by":"crossref","first-page":"16189","DOI":"10.1002\/chem.201704455","volume":"23","author":"GS Lee","year":"2017","unstructured":"Lee, G. S., Namkoong, G., Park, J. & Chen, D. Y. Total synthesis of strychnine. Chem. Eur. J. 23, 16189\u201316193 (2017).","journal-title":"Chem. Eur. J."},{"key":"1264_CR30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nature10232","volume":"475","author":"SB Jones","year":"2011","unstructured":"Jones, S. B., Simmons, B., Mastracchio, A. & MacMillan, D. W. C. Collective synthesis of natural products by means of organocascade catalysis. Nature 475, 183\u2013188 (2011).","journal-title":"Nature"},{"key":"1264_CR31","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1002\/anie.201611734","volume":"56","author":"L Feng","year":"2017","unstructured":"Feng, L. et al. Reaction of donor-acceptor cyclobutanes with indoles: a general protocol for the formal total synthesis of (\u00b1)-strychnine and the total synthesis of (\u00b1)-akuammicine. Angew. Chem. Int. Ed. 56, 3055\u20133058 (2017).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1264_CR32","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1021\/jo100516g","volume":"75","author":"G Sirasani","year":"2010","unstructured":"Sirasani, G., Paul, T., Dougherty, W., Kassel, S. & Andrade, R. B. Concise total syntheses of (\u00b1)-strychnine and (\u00b1)-akuammicine. J. Org. Chem. 75, 3529\u20133532 (2010).","journal-title":"J. Org. Chem."},{"key":"1264_CR33","doi-asserted-by":"crossref","first-page":"9801","DOI":"10.1021\/ja029382u","volume":"125","author":"M Mori","year":"2003","unstructured":"Mori, M., Nakanishi, M., Kajishima, D. & Sato, Y. A novel and general synthetic pathway to Strychnos indole alkaloids: total syntheses of (\u2013)-tubifoline, (\u2013)-dehydrotubifoline, and (\u2013)-strychnine using palladium-catalyzed asymmetric allylic substitution. J. Am. Chem. Soc. 125, 9801\u20139807 (2003).","journal-title":"J. Am. Chem. Soc."},{"key":"1264_CR34","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.1021\/ja010935v","volume":"123","author":"M Ito","year":"2001","unstructured":"Ito, M., Clark, C. W., Mortimore, M. J., Goh, B. & Martin, S. F. Biogenetically inspired approach to the Strychnos alkaloids. Concise syntheses of (\u00b1)-akuammicine and (\u00b1)-strychnine. J. Am. Chem. Soc. 123, 8003\u20138010 (2001).","journal-title":"J. Am. Chem. Soc."},{"key":"1264_CR35","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1021\/ja00126a017","volume":"117","author":"SD Knight","year":"1995","unstructured":"Knight, S. D., Overman, L. E. & Pairaudeau, G. Asymmetric total syntheses of (\u2013)- and (+)-strychnine and the Wieland\u2013Gumlich aldehyde. J. Am. Chem. Soc. 117, 5776\u20135788 (1995).","journal-title":"J. Am. Chem. Soc."},{"key":"1264_CR36","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1021\/jo00089a008","volume":"59","author":"VH Rawal","year":"1994","unstructured":"Rawal, V. H. & Iwasa, S. Short, stereocontrolled synthesis of strychnine. J. Org. Chem. 59, 2685\u20132686 (1994).","journal-title":"J. Org. Chem."},{"key":"1264_CR37","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1021\/ja01647a088","volume":"76","author":"RB Woodward","year":"1954","unstructured":"Woodward, R. B. et al. The total synthesis of strychnine. J. Am. Chem. Soc. 76, 4749\u20134751 (1954).","journal-title":"J. Am. Chem. Soc."},{"key":"1264_CR38","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jep.2011.11.036","volume":"139","author":"F Mbeunkui","year":"2012","unstructured":"Mbeunkui, F. et al. In vitro antiplasmodial activity of indole alkaloids from the stem bark of Geissospermum vellosii. J. Ethnopharmacol. 139, 471\u2013477 (2012).","journal-title":"J. Ethnopharmacol."},{"key":"1264_CR39","doi-asserted-by":"crossref","first-page":"6098","DOI":"10.1021\/acs.joc.0c00572","volume":"85","author":"G Maertens","year":"2020","unstructured":"Maertens, G., Deruer, E., Denis, M. & Canesi, S. Common strategy for the synthesis of some Strychnos indole alkaloids. J. Org. Chem. 85, 6098\u20136108 (2020).","journal-title":"J. Org. Chem."},{"key":"1264_CR40","doi-asserted-by":"crossref","first-page":"7090","DOI":"10.1002\/chem.201601319","volume":"22","author":"G Maertens","year":"2016","unstructured":"Maertens, G. & Canesi, S. Synthesis of the Strychnos alkaloid (\u2212)-strychnopivotine and confirmation of its absolute configuration. Chem. Eur. J. 22, 7090\u20137093 (2016).","journal-title":"Chem. Eur. J."},{"key":"1264_CR41","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1021\/jo8003716","volume":"73","author":"J Boonsombat","year":"2008","unstructured":"Boonsombat, J., Zhang, H., Chughtai, M. J., Hartung, J. & Padwa, A. A general synthetic entry to the pentacyclic Strychnos alkaloid family, using a [4+2]-cycloaddition\/rearrangement cascade sequence. J. Org. Chem. 73, 3539\u20133550 (2008).","journal-title":"J. Org. Chem."},{"key":"1264_CR42","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1002\/anie.201800567","volume":"57","author":"W He","year":"2018","unstructured":"He, W. et al. Highly enantioselective tandem Michael addition of tryptamine-derived oxindoles to alkynones: concise synthesis of Strychnos alkaloids. Angew. Chem. Int. Ed. 57, 3806\u20133809 (2018).","journal-title":". Angew. Chem. Int. Ed."},{"key":"1264_CR43","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1021\/jacs.5b04686","volume":"137","author":"AY Hong","year":"2015","unstructured":"Hong, A. Y. & Vanderwal, C. D. A synthesis of alsmaphorazine B demonstrates the chemical feasibility of a new biogenetic hypothesis. J. Am. Chem. Soc. 137, 7306\u20137309 (2015).","journal-title":"J. Am. Chem. Soc."},{"key":"1264_CR44","doi-asserted-by":"crossref","first-page":"11017","DOI":"10.1021\/ja00149a029","volume":"117","author":"J Bonjoch","year":"1995","unstructured":"Bonjoch, J., Sole, D. & Bosch, J. Studies on the synthesis of Strychnos indole alkaloids. Synthesis of (\u00b1)-dehydrotubifoline. J. Am. Chem. Soc. 117, 11017\u201311018 (1995).","journal-title":"J. Am. Chem. Soc."},{"key":"1264_CR45","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1021\/ja00060a083","volume":"115","author":"VH Rawal","year":"1993","unstructured":"Rawal, V. H., Michoud, C. & Monestel, R. General strategy for the stereocontrolled synthesis of Strychnos alkaloids: a concise synthesis of (\u00b1)-dehydrotubifoline. J. Am. Chem. Soc. 115, 3030\u20133031 (1993).","journal-title":"J. Am. Chem. Soc."},{"key":"1264_CR46","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1021\/ja00013a068","volume":"113","author":"JM Fevig","year":"1991","unstructured":"Fevig, J. M., Marquis, R. W. & Overman, L. E. New approach to Strychnos alkaloids. Stereocontrolled total synthesis of (\u00b1)-dehydrotubifoline. J. Am. Chem. Soc. 113, 5085\u20135086 (1991).","journal-title":"J. Am. Chem. Soc."},{"key":"1264_CR47","doi-asserted-by":"crossref","first-page":"10383","DOI":"10.1021\/jm501189p","volume":"57","author":"CN Teijaro","year":"2014","unstructured":"Teijaro, C. N. et al. Synthesis and biological evaluation of pentacyclic Strychnos alkaloids as selective modulators of the ABCC10 (MRP7) efflux pump. J. Med. Chem. 57, 10383\u201310390 (2014).","journal-title":"J. Med. Chem."},{"key":"1264_CR48","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/adsc.201100929","volume":"354","author":"W Yuan","year":"2012","unstructured":"Yuan, W. & Ma, S. Ligand controlled highly selective copper-catalyzed borylcuprations of allenes with bis(pinacolato)diboron. Adv. Synth. Catal. 354, 1867\u20131872 (2012).","journal-title":"Adv. Synth. Catal."},{"key":"1264_CR49","unstructured":"Anet, F. A. L. & Robinson, R. Conversion of the Wieland\u2013Gumlich aldehyde into strychnine. Chem. Ind. 245\u2013245 (1953)."},{"key":"1264_CR50","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/anie.197506341","volume":"14","author":"HJ Bestmann","year":"1975","unstructured":"Bestmann, H. J. & Sandmeier, D. Simple synthesis of ketenylidenetriphenylphosphorane and its thioanalogs. Angew. Chem. Int. Ed. 14, 634\u2013634 (1975).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1264_CR51","doi-asserted-by":"crossref","first-page":"12632","DOI":"10.1002\/anie.201505198","volume":"54","author":"P Kokkonda","year":"2015","unstructured":"Kokkonda, P. et al. Biomimetic total syntheses of (\u2013)-leucoridines A and C through the dimerization of (\u2013)-dihydrovalparicine. Angew. Chem. Int. Ed. 54, 12632\u201312635 (2015).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1264_CR52","doi-asserted-by":"crossref","first-page":"13105","DOI":"10.1002\/anie.202102416","volume":"60","author":"Z Yang","year":"2021","unstructured":"Yang, Z. et al. Asymmetric total synthesis of sarpagine and koumine alkaloids. Angew. Chem. Int. Ed. 60, 13105\u201313111 (2021).","journal-title":"Angew. Chem. Int. Ed."}],"container-title":["Nature Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41557-023-01264-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41557-023-01264-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41557-023-01264-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T07:08:49Z","timestamp":1690960129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41557-023-01264-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,26]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["1264"],"URL":"https:\/\/doi.org\/10.1038\/s41557-023-01264-4","relation":{},"ISSN":["1755-4330","1755-4349"],"issn-type":[{"value":"1755-4330","type":"print"},{"value":"1755-4349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,26]]},"assertion":[{"value":"10 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}