{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:17:51Z","timestamp":1793157471756,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000266","name":"RCUK | Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/S013172\/1"],"award-info":[{"award-number":["EP\/S013172\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"RCUK | Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/S013172\/1"],"award-info":[{"award-number":["EP\/S013172\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"RCUK | Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/V028995\/1"],"award-info":[{"award-number":["EP\/V028995\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","award":["no grant number available"],"award-info":[{"award-number":["no grant number available"]}],"id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat. Chem."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    [\n                    <jats:italic>n<\/jats:italic>\n                    .1.1]Propellanes are key precursors to bicyclo[\n                    <jats:italic>n<\/jats:italic>\n                    .1.1]alkanes, rigid small-ring hydrocarbons that have emerged as important building blocks in contemporary drug design as bioisosteres for disubstituted benzene rings. [\n                    <jats:italic>n<\/jats:italic>\n                    .1.1]Propellanes featuring heterocyclic rings could enable the direct synthesis of a wide diversity of bridged bicyclic heterocycles, which should exhibit superior physicochemical profiles compared to their established carbocyclic analogues. Here we report the unified synthesis of a family of heterocyclic [3.1.1]propellanes featuring oxygen, nitrogen and sulfur heteroatoms in the three-carbon bridge. The approaches we have developed are necessarily distinct from the established routes to carbocyclic propellanes, and utilize a common precursor that is conveniently assembled on a multigram scale via rhodium-catalysed cyclopropanation. These hetero[3.1.1]propellanes undergo a range of radical ring-opening reactions, affording bridged heterocycles that are of high utility in drug-discovery programmes.\n                  <\/jats:p>","DOI":"10.1038\/s41557-026-02072-2","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T10:02:43Z","timestamp":1772013763000},"page":"502-508","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hetero[3.1.1]propellanes"],"prefix":"10.1038","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2834-8758","authenticated-orcid":false,"given":"Rebecca I.","family":"Revie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-8334","authenticated-orcid":false,"given":"Ayan","family":"Dasgupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6864-1971","authenticated-orcid":false,"given":"Yasmine","family":"Biddick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1683-2066","authenticated-orcid":false,"given":"Kirsten E.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4149-0494","authenticated-orcid":false,"given":"Edward A.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"2072_CR1","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/s41570-024-00623-0","volume":"8","author":"J Tsien","year":"2024","unstructured":"Tsien, J., Hu, C., Merchant, R. R. & Qin, T. Three-dimensional saturated C(sp3)-rich bioisosteres for benzene. Nat. Rev. Chem. 8, 605\u2013627 (2024).","journal-title":"Nat. Rev. Chem."},{"key":"2072_CR2","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1039\/C8OB02812E","volume":"17","author":"PK Mykhailiuk","year":"2019","unstructured":"Mykhailiuk, P. K. Saturated bioisosteres of benzene: where to go next?. Org. Biomol. Chem. 17, 2839\u20132849 (2019).","journal-title":"Org. Biomol. Chem."},{"key":"2072_CR3","doi-asserted-by":"publisher","first-page":"6752","DOI":"10.1021\/jm901241e","volume":"52","author":"F Lovering","year":"2009","unstructured":"Lovering, F., Bikker, J. & Humblet, C. Escape from flatland: increasing saturation as an approach to improving clinical success. J. Med. Chem. 52, 6752\u20136756 (2009).","journal-title":"J. Med. Chem."},{"key":"2072_CR4","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1055\/s-0043-1775395","volume":"57","author":"Z Fang","year":"2024","unstructured":"Fang, Z., Xu, Q., Lu, X., Wan, N. & Yang, W.-L. The application of bicyclo[1.1.1]pentane as a bioisostere of the phenyl ring in pharmaceutical chemistry. Synthesis 57, 1171\u20131179 (2024).","journal-title":"Synthesis"},{"key":"2072_CR5","doi-asserted-by":"publisher","first-page":"14046","DOI":"10.1021\/acs.jmedchem.1c01215","volume":"64","author":"MAM Subbaiah","year":"2021","unstructured":"Subbaiah, M. A. M. & Meanwell, N. A. Bioisosteres of the phenyl ring: recent strategic applications in lead optimization and drug design. J. Med. Chem. 64, 14046\u201314128 (2021).","journal-title":"J. Med. Chem."},{"key":"2072_CR6","doi-asserted-by":"publisher","first-page":"3414","DOI":"10.1021\/jm300094u","volume":"55","author":"AF Stepan","year":"2012","unstructured":"Stepan, A. F. et al. Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active gamma-secretase inhibitor. J. Med. Chem. 55, 3414\u20133424 (2012).","journal-title":"J. Med. Chem."},{"key":"2072_CR7","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/s41586-022-05290-z","volume":"611","author":"N Frank","year":"2022","unstructured":"Frank, N. et al. Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane. Nature 611, 721\u2013726 (2022).","journal-title":"Nature"},{"key":"2072_CR8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/cber.19891220233","volume":"122","author":"J Belzner","year":"1989","unstructured":"Belzner, J. et al. Concerning the synthesis of [1.1.1]propellane. Chem. Ber. 122, 397\u2013398 (1989).","journal-title":"Chem. Ber."},{"key":"2072_CR9","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1126\/science.aad6252","volume":"351","author":"R Gianatassio","year":"2016","unstructured":"Gianatassio, R. et al. Organic chemistry. Strain-release amination. Science 351, 241\u2013246 (2016).","journal-title":"Science"},{"key":"2072_CR10","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1021\/jacsau.3c00014","volume":"3","author":"BR Shire","year":"2023","unstructured":"Shire, B. R. & Anderson, E. A. Conquering the synthesis and functionalization of bicyclo[1.1.1]pentanes. JACS Au 3, 1539\u20131553 (2023).","journal-title":"JACS Au"},{"key":"2072_CR11","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1016\/j.cclet.2020.04.023","volume":"31","author":"F-S He","year":"2020","unstructured":"He, F.-S., Xie, S., Yao, Y. & Wu, J. Recent advances in the applications of [1.1.1]-propellane in organic synthesis. Chin. Chem. Lett. 31, 3065\u20133072 (2020).","journal-title":"Chin. Chem. Lett."},{"key":"2072_CR12","doi-asserted-by":"publisher","first-page":"100070","DOI":"10.1016\/j.tchem.2024.100070","volume":"9","author":"Q-Q Hu","year":"2024","unstructured":"Hu, Q.-Q., Chen, J., Yang, Y., Yang, H. & Zhou, L. Strain-release transformations of bicyclo[1.1.0]butanes and [1.1.1]propellanes. Tetrahedron Chem 9, 100070 (2024).","journal-title":"Tetrahedron Chem"},{"key":"2072_CR13","doi-asserted-by":"publisher","first-page":"5684","DOI":"10.1002\/anie.201603951","volume":"56","author":"AM Dilmac","year":"2017","unstructured":"Dilmac, A. M., Spuling, E., de Meijere, A. & Brase, S. Propellanes-from a chemical curiosity to \u2018explosive\u2019 materials and natural products. Angew. Chem. Int. Ed. 56, 5684\u20135718 (2017).","journal-title":"Angew. Chem. Int. Ed."},{"key":"2072_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202304246","volume":"62","author":"D Dibchak","year":"2023","unstructured":"Dibchak, D. et al. General synthesis of 3-azabicyclo[3.1.1]heptanes and evaluation of their properties as saturated isosteres. Angew. Chem. Int. Ed. 62, e202304246 (2023).","journal-title":"Angew. Chem. Int. Ed."},{"key":"2072_CR15","doi-asserted-by":"publisher","first-page":"e202505519","DOI":"10.1002\/anie.202505519","volume":"64","author":"D Dibchak","year":"2025","unstructured":"Dibchak, D. & Mykhailiuk, P. 3-Oxabicyclo[3.1.1]heptane as an isostere of meta-benzene. Angew. Chem. Int. Ed. 64, e202505519 (2025).","journal-title":"Angew. Chem. Int. Ed."},{"key":"2072_CR16","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1021\/acs.orglett.5c00646","volume":"27","author":"J Morvan","year":"2024","unstructured":"Morvan, J., Renders, E., Buijnsters, P. J. J. A. & Ryabchuk, P. 3-Oxabicyclo[3.1.1]heptanes as isosteres of meta-substituted benzene rings. Org. Lett. 27, 3291\u20133295 (2024).","journal-title":"Org. Lett."},{"key":"2072_CR17","doi-asserted-by":"publisher","first-page":"21069","DOI":"10.1021\/jacs.4c06436","volume":"146","author":"X Wang","year":"2024","unstructured":"Wang, X., Gao, R. & Li, X. Catalytic asymmetric construction of chiral polysubstituted 3-azabicyclo[3.1.1]heptanes by copper-catalyzed stereoselective formal [4\u03c0\u2009+\u20092\u03c3] cycloaddition. J. Am. Chem. Soc. 146, 21069\u201321077 (2024).","journal-title":"J. Am. Chem. Soc."},{"key":"2072_CR18","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202402730","volume":"63","author":"Y Liang","year":"2024","unstructured":"Liang, Y., Nematswerani, R., Daniliuc, C. G. & Glorius, F. Silver-enabled cycloaddition of bicyclobutanes with isocyanides for the synthesis of polysubstituted 3-azabicyclo[3.1.1]heptanes. Angew. Chem. Int. Ed. 63, e202402730 (2024).","journal-title":"Angew. Chem. Int. Ed."},{"key":"2072_CR19","doi-asserted-by":"publisher","first-page":"18565","DOI":"10.1021\/jacs.4c04485","volume":"146","author":"Z Lin","year":"2024","unstructured":"Lin, Z., Ren, H., Lin, X., Yu, X. & Zheng, J. Synthesis of azabicyclo[3.1.1]heptenes enabled by catalyst-controlled annulations of bicyclo[1.1.0]butanes with vinyl azides. J. Am. Chem. Soc. 146, 18565\u201318575 (2024).","journal-title":"J. Am. Chem. Soc."},{"key":"2072_CR20","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1055\/a-2367-2244","volume":"57","author":"J Dong","year":"2025","unstructured":"Dong, J., Liao, H. & Xue, D. Recent advances in the synthesis of bicyclo[3.1.1]heptanes. Synthesis 57, 722\u2013731 (2025).","journal-title":"Synthesis"},{"key":"2072_CR21","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1055\/a-2406-3243","volume":"36","author":"J-J Feng","year":"2025","unstructured":"Feng, J.-J. Recent progress in (3+3) cycloadditions of bicyclobutanes to access bicyclo[3.1.1]heptane derivatives. Synlett 36, 621\u2013629 (2025).","journal-title":"Synlett"},{"key":"2072_CR22","doi-asserted-by":"publisher","first-page":"27204","DOI":"10.1021\/jacs.4c11296","volume":"146","author":"S Dutta","year":"2024","unstructured":"Dutta, S., Daniliuc, C. G., M\u00fcck-Lichtenfeld, C. & Studer, A. Formal [2\u03c3\u2009+\u20092\u03c3]-cycloaddition of aziridines with bicyclo[1.1.0]butanes: access to enantiopure 2-azabicyclo[3.1.1]heptane derivatives. J. Am. Chem. Soc. 146, 27204\u201327212 (2024).","journal-title":"J. Am. Chem. Soc."},{"key":"2072_CR23","doi-asserted-by":"publisher","first-page":"19621","DOI":"10.1021\/jacs.4c01851","volume":"146","author":"J-L Zhou","year":"2024","unstructured":"Zhou, J.-L. et al. Palladium-catalyzed ligand-controlled switchable hetero-(5\u2009+\u20093)\/enantioselective [2\u03c3\u2009+\u20092\u03c3] cycloadditions of bicyclobutanes with vinyl oxiranes. J. Am. Chem. Soc. 146, 19621\u201319628 (2024).","journal-title":"J. Am. Chem. Soc."},{"key":"2072_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202408578","volume":"63","author":"Y Xiao","year":"2024","unstructured":"Xiao, Y. et al. Divergent synthesis of sulfur-containing bridged cyclobutanes by Lewis acid catalyzed formal cycloadditions of pyridinium 1,4-zwitterionic thiolates and bicyclobutanes. Angew. Chem. Int. Ed. 63, e202408578 (2024).","journal-title":"Angew. Chem. Int. Ed."},{"key":"2072_CR25","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202318476","volume":"136","author":"J Zhang","year":"2024","unstructured":"Zhang, J., Su, J.-Y., Zheng, H., Li, H. & Deng, W.-P. Eu(OTf)3-catalyzed formal dipolar [4\u03c0\u2009+\u20092\u03c3] cycloaddition of bicyclo-[1.1.0]butanes with nitrones: access to polysubstituted 2-oxa-3-azabicyclo[3.1.1]heptanes. Angew. Chem. 136, e202318476 (2024).","journal-title":"Angew. Chem."},{"key":"2072_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52419-x","volume":"15","author":"W-B Wu","year":"2024","unstructured":"Wu, W.-B. et al. Enantioselective formal (3\u2009+\u20093) cycloaddition of bicyclobutanes with nitrones enabled by asymmetric Lewis acid catalysis. Nat. Commun. 15, 8005 (2024).","journal-title":"Nat. Commun."},{"key":"2072_CR27","doi-asserted-by":"publisher","first-page":"27274","DOI":"10.1021\/jacs.4c10123","volume":"146","author":"X-G Zhang","year":"2024","unstructured":"Zhang, X.-G., Zhou, Z.-Y., Li, J.-X., Chen, J.-J. & Zhou, Q.-L. Copper-catalyzed enantioselective [4\u03c0\u2009+\u20092\u03c3] cycloaddition of bicyclobutanes with nitrones. J. Am. Chem. Soc. 146, 27274\u201327281 (2024).","journal-title":"J. Am. Chem. Soc."},{"key":"2072_CR28","doi-asserted-by":"publisher","first-page":"13008","DOI":"10.1039\/D4CC04730C","volume":"60","author":"K Dhake","year":"2024","unstructured":"Dhake, K. et al. Diastereoselective dearomative cycloaddition of bicyclobutanes with pyridinium ylides: a modular approach to multisubstituted azabicyclo[3.1.1]heptanes. Chem. Commun. 60, 13008\u201313011 (2024).","journal-title":"Chem. Commun."},{"key":"2072_CR29","doi-asserted-by":"publisher","first-page":"4895","DOI":"10.1039\/D0SC01386B","volume":"11","author":"AJ Sterling","year":"2020","unstructured":"Sterling, A. J., D\u00fcrr, A. B., Smith, R. C., Anderson, E. A. & Duarte, F. Rationalizing the diverse reactivity of [1.1.1]propellane through \u03c3\u2013\u03c0-delocalization. Chem. Sci. 11, 4895\u20134903 (2020).","journal-title":"Chem. Sci."},{"key":"2072_CR30","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1021\/jo00001a058","volume":"56","author":"P Kaszynski","year":"1991","unstructured":"Kaszynski, P., McMurdie, N. D. & Michl, J. Synthesis of doubly bridgehead substituted bicyclo[1.1.1]pentanes. Radical transformation of bridgehead halides and carboxylic acids. J. Org. Chem. 56, 307\u2013316 (1991).","journal-title":"J. Org. Chem."},{"key":"2072_CR31","doi-asserted-by":"publisher","first-page":"5295","DOI":"10.1039\/C8SC01355A","volume":"9","author":"DFJ Caputo","year":"2018","unstructured":"Caputo, D. F. J. et al. Synthesis and applications of highly functionalized 1-halo-3-substituted bicyclo[1.1.1]pentanes. Chem. Sci. 9, 5295\u20135300 (2018).","journal-title":"Chem. Sci."},{"key":"2072_CR32","doi-asserted-by":"publisher","first-page":"9568","DOI":"10.1021\/acscatal.9b03190","volume":"9","author":"J Nugent","year":"2019","unstructured":"Nugent, J. et al. A general route to bicyclo[1.1.1]pentanes through photoredox catalysis. ACS Catal. 9, 9568\u20139574 (2019).","journal-title":"ACS Catal."},{"key":"2072_CR33","doi-asserted-by":"publisher","first-page":"9729","DOI":"10.1021\/jacs.1c04180","volume":"143","author":"HD Pickford","year":"2021","unstructured":"Pickford, H. D. et al. Twofold radical-based synthesis of N,C-difunctionalized bicyclo[1.1.1]pentanes. J. Am. Chem. Soc. 143, 9729\u20139736 (2021).","journal-title":"J. Am. Chem. Soc."},{"key":"2072_CR34","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202213508","volume":"62","author":"HD Pickford","year":"2023","unstructured":"Pickford, H. D. et al. Rapid and scalable halosulfonylation of strain-release reagents. Angew. Chem. Int. Ed. 62, e202213508 (2023).","journal-title":"Angew. Chem. Int. Ed."},{"key":"2072_CR35","doi-asserted-by":"publisher","first-page":"10918","DOI":"10.1039\/D4SC01368A","volume":"15","author":"J Nugent","year":"2024","unstructured":"Nugent, J. et al. \u03b1-amino bicycloalkylation through organophotoredox catalysis. Chem. Sci. 15, 10918\u201310925 (2024).","journal-title":"Chem. Sci."},{"key":"2072_CR36","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1002\/chem.201704105","volume":"24","author":"RM B\u00e4r","year":"2018","unstructured":"B\u00e4r, R. M., Kirschner, S., Nieger, M. & Br\u00e4se, S. Alkyl and aryl thiol addition to [1.1.1]propellane: scope and limitations of a fast conjugation reaction. Chem. Eur. J. 24, 1373\u20131382 (2018).","journal-title":"Chem. Eur. J."},{"key":"2072_CR37","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1016\/S0040-4039(00)84310-5","volume":"27","author":"KB Wiberg","year":"1986","unstructured":"Wiberg, K. B., Waddell, S. T. & Laidig, K. [1.1.1]Propellane: reaction with free radicals. Tetrahedron Lett. 27, 1553\u20131556 (1986).","journal-title":"Tetrahedron Lett."},{"key":"2072_CR38","doi-asserted-by":"publisher","first-page":"131692","DOI":"10.1016\/j.tet.2020.131692","volume":"76","author":"Z Wu","year":"2020","unstructured":"Wu, Z., Xu, Y., Wu, X. & Zhu, C. Synthesis of selenoether and thioether functionalized bicyclo[1.1.1]pentanes. Tetrahedron 76, 131692 (2020).","journal-title":"Tetrahedron"},{"key":"2072_CR39","doi-asserted-by":"publisher","first-page":"21848","DOI":"10.1021\/jacs.2c09733","volume":"144","author":"T Iida","year":"2022","unstructured":"Iida, T. et al. Practical and facile access to bicyclo[3.1.1]heptanes: potent bioisosteres of meta-substituted benzenes. J. Am. Chem. Soc. 144, 21848\u201321852 (2022).","journal-title":"J. Am. Chem. Soc."},{"key":"2072_CR40","doi-asserted-by":"publisher","first-page":"6206","DOI":"10.1021\/jo00049a030","volume":"57","author":"JL Adcock","year":"1992","unstructured":"Adcock, J. L. & Gakh, A. A. Nucleophilic substitution in 1-substituted 3-iodobicyclo[1.1.1]pentanes. A new synthetic route to functionalized bicyclo[1.1.1]pentane derivatives. J. Org. Chem. 57, 6206\u20136210 (1992).","journal-title":"J. Org. Chem."},{"key":"2072_CR41","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1002\/cber.19911240326","volume":"124","author":"H Bothe","year":"1991","unstructured":"Bothe, H. & Schl \u00fcter, A.-D. Synthesis of monosubstituted [1.1.1]propellanes. Chem. Ber. 124, 587\u2013590 (1991).","journal-title":"Chem. Ber."},{"key":"2072_CR42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2108881118","volume":"118","author":"J-X Zhao","year":"2021","unstructured":"Zhao, J.-X. et al. 1,2-Difunctionalized bicyclo[1.1.1]pentanes: long-sought-after mimetics for ortho\/meta-substituted arenes. Proc. Natl Acad. Sci. USA 118, e2108881118 (2021).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2072_CR43","doi-asserted-by":"publisher","first-page":"11866","DOI":"10.1002\/anie.202004090","volume":"59","author":"J Nugent","year":"2020","unstructured":"Nugent, J. et al. Synthesis of all-carbon disubstituted bicyclo[1.1.1]pentanes by iron-catalyzed Kumada cross-coupling. Angew. Chem. Int. Ed. 59, 11866\u201311870 (2020).","journal-title":"Angew. Chem. Int. Ed."}],"container-title":["Nature Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41557-026-02072-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41557-026-02072-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41557-026-02072-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:01:43Z","timestamp":1772751703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41557-026-02072-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["2072"],"URL":"https:\/\/doi.org\/10.1038\/s41557-026-02072-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2024-tnx0l","asserted-by":"object"}]},"ISSN":["1755-4330","1755-4349"],"issn-type":[{"value":"1755-4330","type":"print"},{"value":"1755-4349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"22 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A patent has been filed by E.A.A. and R.I.R. (UK Patent application no. 2415923.8, granted) that covers all of the research described in this paper. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}