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The segregated proteinosomes exhibit tunable membrane wettability, engage in cross-community chemical signalling and undergo signal-induced reversals in phase compatibility to produce reconfigurable networks capable of protocell-mediated recruitment and dispatchment. We exploit the protocell phase dynamics to spatiotemporally modulate DNase I activity in a subpopulation of translocating proteinosomes. Our methodology provides a platform for developing protocell communities with self-regulated spatiotemporal order and offers opportunities in cytomimetic modelling and colloidal systems chemistry.<\/jats:p>","DOI":"10.1038\/s41557-026-02225-3","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:01:26Z","timestamp":1787043686000},"page":"1828-1837","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Signal-induced recruitment and dispatchment in reconfigurable phase-separated protocell networks"],"prefix":"10.1038","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8319-0553","authenticated-orcid":false,"given":"Zhuping","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3455-7259","authenticated-orcid":false,"given":"Rui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3012-8964","authenticated-orcid":false,"given":"Stephen","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"2225_CR1","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.1073\/pnas.1815063116","volume":"116","author":"T Fujimori","year":"2019","unstructured":"Fujimori, T., Nakajima, A., Shimada, N. & Sawai, S. 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