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Chem."],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The \u03b1-arylation of carbonyl compounds is a cornerstone transformation in the synthesis of pharmaceuticals and natural products. Despite decades of efforts using transition metal, main-group and photoredox strategies, a general and practical \u03b1-arylation method with broad substrate scope has remained elusive. Here we show that 9-bismatriptycene (BisTrip), a rigid, shackled form of triphenylbismuth, functions as a universal aryl group transporter, enabling controlled and regiospecific \u03b1-arylation of diverse ketones, allowing the formation of sterically demanding quaternary centres and incorporation of iodoaryl units. BisTrip is readily loaded with aryl groups by a one-pot procedure using arylboronic acids to give Aryl-BisTrip and, after transferring the aryl to the enolate, is recovered quantitatively. Arylation of lithium enolates proceeds within seconds even at \u221278\u2009\u00b0C and shows high fidelity in a memory-of-chirality experiment. Computations support a low barrier for C\u2212C bond formation and account for the observed axial selectivity, establishing BisTrip as a practical platform for \u03b1-arylation.<\/jats:p>","DOI":"10.1038\/s41557-026-02231-5","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:01:56Z","timestamp":1787043716000},"page":"1957-1967","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Regiospecific \u03b1-arylation of diverse carbonyl compounds using an organobismuth transporter"],"prefix":"10.1038","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1400-8025","authenticated-orcid":false,"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8228-7409","authenticated-orcid":false,"given":"Filippo","family":"Carpaneto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3209-3841","authenticated-orcid":false,"given":"Pan-Pan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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