{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T11:51:17Z","timestamp":1793361077591,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Hum Behav"],"DOI":"10.1038\/s41562-020-01031-2","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T17:04:35Z","timestamp":1610989475000},"page":"795-801","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Genetic loci shared between major depression and intelligence with mixed directions of effect"],"prefix":"10.1038","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8179-2788","authenticated-orcid":false,"given":"Shahram","family":"Bahrami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7467-250X","authenticated-orcid":false,"given":"Alexey","family":"Shadrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Frei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6865-8795","authenticated-orcid":false,"given":"Kevin S.","family":"O\u2019Connell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7968-8642","authenticated-orcid":false,"given":"Francesco","family":"Bettella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Krull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9437-2128","authenticated-orcid":false,"given":"Chun C.","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan I.","family":"R\u00f8ssberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1666-4701","authenticated-orcid":false,"given":"Guy","family":"Hindley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torill","family":"Ueland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders M.","family":"Dale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-8061","authenticated-orcid":false,"given":"Srdjan","family":"Djurovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6442-1179","authenticated-orcid":false,"given":"Nils Eiel","family":"Steen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3761-5215","authenticated-orcid":false,"given":"Olav B.","family":"Smeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-3568","authenticated-orcid":false,"given":"Ole A.","family":"Andreassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"1031_CR1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/S0140-6736(11)60602-8","volume":"379","author":"DJ Kupfer","year":"2012","unstructured":"Kupfer, D. J., Frank, E. & Phillips, M. L. Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet 379, 1045\u20131055 (2012).","journal-title":"Lancet"},{"key":"1031_CR2","doi-asserted-by":"publisher","first-page":"e1001547","DOI":"10.1371\/journal.pmed.1001547","volume":"10","author":"AJ Ferrari","year":"2013","unstructured":"Ferrari, A. J. et al. Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Med. 10, e1001547 (2013).","journal-title":"PLoS Med."},{"key":"1031_CR3","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.euroneuro.2011.08.008","volume":"21","author":"A Gustavsson","year":"2011","unstructured":"Gustavsson, A. et al. Cost of disorders of the brain in Europe 2010. Eur. Neuropsychopharmacol. 21, 718\u2013779 (2011).","journal-title":"Eur. Neuropsychopharmacol."},{"key":"1031_CR4","doi-asserted-by":"publisher","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","volume":"289","author":"RC Kessler","year":"2003","unstructured":"Kessler, R. C. et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 289, 3095\u20133105 (2003).","journal-title":"JAMA"},{"key":"1031_CR5","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1017\/S0033291713002778","volume":"44","author":"D Vancampfort","year":"2014","unstructured":"Vancampfort, D. et al. Metabolic syndrome and metabolic abnormalities in patients with major depressive disorder: a meta-analysis of prevalences and moderating variables. Psychol. Med. 44, 2017\u20132028 (2014).","journal-title":"Psychol. Med."},{"key":"1031_CR6","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1126\/science.aaa8954","volume":"349","author":"DH Geschwind","year":"2015","unstructured":"Geschwind, D. H. & Flint, J. Genetics and genomics of psychiatric disease. Science 349, 1489\u20131494 (2015).","journal-title":"Science"},{"key":"1031_CR7","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1017\/S1092852918001207","volume":"24","author":"Z Pan","year":"2019","unstructured":"Pan, Z. et al. Cognitive impairment in major depressive disorder. CNS Spectr. 24, 22\u201329 (2019).","journal-title":"CNS Spectr."},{"key":"1031_CR8","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.psychres.2016.12.031","volume":"248","author":"AG Szmulewicz","year":"2017","unstructured":"Szmulewicz, A. G. et al. Neuropsychological profiles of major depressive disorder and bipolar disorder during euthymia. A systematic literature review of comparative studies. Psychiatry Res. 248, 127\u2013133 (2017).","journal-title":"Psychiatry Res."},{"key":"1031_CR9","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1176\/appi.ajp.2008.08050721","volume":"165","author":"AT Beck","year":"2008","unstructured":"Beck, A. T. The evolution of the cognitive model of depression and its neurobiological correlates. Am. J. Psychiatry 165, 969\u2013977 (2008).","journal-title":"Am. J. Psychiatry"},{"key":"1031_CR10","doi-asserted-by":"publisher","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","volume":"2","author":"C Otte","year":"2016","unstructured":"Otte, C. et al. Major depressive disorder. Nat. Rev. Dis. Primers 2, 16065 (2016).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"1031_CR11","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.eurpsy.2016.12.012","volume":"43","author":"LB Navrady","year":"2017","unstructured":"Navrady, L. B. et al. Intelligence and neuroticism in relation to depression and psychological distress: evidence from two large population cohorts. Eur. Psychiatry 43, 58\u201365 (2017).","journal-title":"Eur. Psychiatry"},{"key":"1031_CR12","doi-asserted-by":"crossref","unstructured":"Cross-Disorder Group of the Psychiatric Genomics Consortium. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat. Genet. 45, 984\u2013994 (2013).","DOI":"10.1038\/ng.2711"},{"key":"1031_CR13","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/ng.3211","volume":"47","author":"BK Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan, B. K. et al. LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat. Genet. 47, 291\u2013295 (2015).","journal-title":"Nat. Genet."},{"key":"1031_CR14","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/ng.3623","volume":"48","author":"CL Hyde","year":"2016","unstructured":"Hyde, C. L. et al. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nat. Genet. 48, 1031\u20131036 (2016).","journal-title":"Nat. Genet."},{"key":"1031_CR15","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41588-018-0090-3","volume":"50","author":"NR Wray","year":"2018","unstructured":"Wray, N. R. et al. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat. Genet. 50, 668\u2013681 (2018).","journal-title":"Nat. Genet."},{"key":"1031_CR16","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/s41588-018-0152-6","volume":"50","author":"JE Savage","year":"2018","unstructured":"Savage, J. E. et al. Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nat. Genet. 50, 912\u2013919 (2018).","journal-title":"Nat. Genet."},{"key":"1031_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04362-x","volume":"9","author":"G Davies","year":"2018","unstructured":"Davies, G. et al. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat. Commun. 9, 2098 (2018).","journal-title":"Nat. Commun."},{"key":"1031_CR18","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1126\/science.1076641","volume":"298","author":"AM Glazier","year":"2002","unstructured":"Glazier, A. M., Nadeau, J. H. & Aitman, T. J. Finding genes that underlie complex traits. Science 298, 2345\u20132349 (2002).","journal-title":"Science"},{"key":"1031_CR19","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/j.cell.2017.05.038","volume":"169","author":"EA Boyle","year":"2017","unstructured":"Boyle, E. A., Li, Y. I. & Pritchard, J. K. An expanded view of complex traits: from polygenic to omnigenic. Cell 169, 1177\u20131186 (2017).","journal-title":"Cell"},{"key":"1031_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10310-0","volume":"10","author":"O Frei","year":"2019","unstructured":"Frei, O. et al. Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. Nat. Commun. 10, 2417 (2019).","journal-title":"Nat. Commun."},{"key":"1031_CR21","doi-asserted-by":"crossref","unstructured":"Efron, B. Large-Scale Inference: Empirical Bayes Methods for Estimation, Testing, and Prediction Vol. 1 (Cambridge Univ. Press, 2010).","DOI":"10.1017\/CBO9780511761362"},{"key":"1031_CR22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/schbul\/sbt168","volume":"40","author":"OA Andreassen","year":"2014","unstructured":"Andreassen, O. A., Thompson, W. K. & Dale, A. M. Boosting the power of schizophrenia genetics by leveraging new statistical tools. Schizophr. Bull. 40, 13\u201317 (2014).","journal-title":"Schizophr. Bull."},{"key":"1031_CR23","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00439-019-02060-2","volume":"139","author":"OB Smeland","year":"2019","unstructured":"Smeland, O. B. et al. Discovery of shared genomic loci using the conditional false discovery rate approach. Hum. Genet. 139, 85\u201394 (2019).","journal-title":"Hum. Genet."},{"key":"1031_CR24","doi-asserted-by":"publisher","first-page":"e1005803","DOI":"10.1371\/journal.pgen.1005803","volume":"12","author":"Y Wang","year":"2016","unstructured":"Wang, Y. et al. Leveraging genomic annotations and pleiotropic enrichment for improved replication rates in schizophrenia GWAS. PLoS Genet. 12, e1005803 (2016).","journal-title":"PLoS Genet."},{"key":"1031_CR25","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/s41380-018-0332-x","volume":"25","author":"OB Smeland","year":"2018","unstructured":"Smeland, O. B. et al. Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder and general cognitive ability. Mol. Psychiatry 25, 844\u2013853 (2018).","journal-title":"Mol. Psychiatry"},{"key":"1031_CR26","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.ajhg.2013.01.001","volume":"92","author":"OA Andreassen","year":"2013","unstructured":"Andreassen, O. A. et al. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am. J. Hum. Genet 92, 197\u2013209 (2013).","journal-title":"Am. J. Hum. Genet"},{"key":"1031_CR27","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/ng.2892","volume":"46","author":"M Kircher","year":"2014","unstructured":"Kircher, M. et al. A general framework for estimating the relative pathogenicity of human genetic variants. Nat. Genet. 46, 310\u2013315 (2014).","journal-title":"Nat. Genet."},{"key":"1031_CR28","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1101\/gr.137323.112","volume":"22","author":"AP Boyle","year":"2012","unstructured":"Boyle, A. P. et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res. 22, 1790\u20131797 (2012).","journal-title":"Genome Res."},{"key":"1031_CR29","doi-asserted-by":"crossref","unstructured":"GTEx Consortium. Genetic effects on gene expression across human tissues. Nature 550, 204\u2013213 (2017).","DOI":"10.1038\/nature24277"},{"key":"1031_CR30","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/mp.2012.21","volume":"18","author":"Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium.","year":"2013","unstructured":"Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium. A mega-analysis of genome-wide association studies for major depressive disorder. Mol. Psychiatry 18, 497\u2013511 (2013).","journal-title":"Mol. Psychiatry"},{"key":"1031_CR31","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1001\/jamapsychiatry.2017.1986","volume":"74","author":"OB Smeland","year":"2017","unstructured":"Smeland, O. B. et al. Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function. JAMA Psychiatry 74, 1065\u20131075 (2017).","journal-title":"JAMA Psychiatry"},{"key":"1031_CR32","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s11920-009-0045-6","volume":"11","author":"DM Barch","year":"2009","unstructured":"Barch, D. M. Neuropsychological abnormalities in schizophrenia and major mood disorders: similarities and differences. Curr. Psychiatry Rep. 11, 313\u2013319 (2009).","journal-title":"Curr. Psychiatry Rep."},{"key":"1031_CR33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.copsyc.2018.07.007","volume":"27","author":"WD Hill","year":"2018","unstructured":"Hill, W. D., Harris, S. E. & Deary, I. J. What genome-wide association studies reveal about the association between intelligence and mental health. Curr. Opin. Psychol. 27, 25\u201330 (2018).","journal-title":"Curr. Opin. Psychol."},{"key":"1031_CR34","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1177\/1745691617699653","volume":"12","author":"CL Taylor","year":"2017","unstructured":"Taylor, C. L. Creativity and mood disorder: a systematic review and meta-analysis. Perspect. Psychol. Sci. 12, 1040\u20131076 (2017).","journal-title":"Perspect. Psychol. Sci."},{"key":"1031_CR35","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1038\/nn.3801","volume":"17","author":"A Ramasamy","year":"2014","unstructured":"Ramasamy, A. et al. Genetic variability in the regulation of gene expression in ten regions of the human brain. Nat. Neurosci. 17, 1418\u20131428 (2014).","journal-title":"Nat. Neurosci."},{"key":"1031_CR36","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.ajhg.2016.03.002","volume":"98","author":"B Fregeau","year":"2016","unstructured":"Fregeau, B. et al. De novo mutations of RERE cause a genetic syndrome with features that overlap those associated with proximal 1p36 deletions. Am. J. Hum. Genet. 98, 963\u2013970 (2016).","journal-title":"Am. J. Hum. Genet."},{"key":"1031_CR37","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.pnpbp.2017.02.016","volume":"76","author":"S Hidese","year":"2017","unstructured":"Hidese, S. et al. Cerebrospinal fluid neural cell adhesion molecule levels and their correlation with clinical variables in patients with schizophrenia, bipolar disorder, and major depressive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 76, 12\u201318 (2017).","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"1031_CR38","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nrn2793","volume":"11","author":"IJ Deary","year":"2010","unstructured":"Deary, I. J., Penke, L. & Johnson, W. The neuroscience of human intelligence differences. Nat. Rev. Neurosci. 11, 201\u2013211 (2010).","journal-title":"Nat. Rev. Neurosci."},{"key":"1031_CR39","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3389\/fnmol.2018.00199","volume":"11","author":"DM Bannerman","year":"2018","unstructured":"Bannerman, D. M. et al. Somatic accumulation of GluA1-AMPA receptors leads to selective cognitive impairments in mice. Front. Mol. Neurosci. 11, 199 (2018).","journal-title":"Front. Mol. Neurosci."},{"key":"1031_CR40","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1177\/08830738030180100601","volume":"18","author":"DD Armstrong","year":"2003","unstructured":"Armstrong, D. D., Deguchi, K. & Antallfy, B. Survey of MeCP2 in the Rett syndrome and the non-Rett syndrome brain. J. Child Neurol. 18, 683\u2013687 (2003).","journal-title":"J. Child Neurol."},{"key":"1031_CR41","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1152\/physrev.00036.2014","volume":"95","author":"Y Hara","year":"2015","unstructured":"Hara, Y., Waters, E. M., McEwen, B. S. & Morrison, J. H. Estrogen effects on cognitive and synaptic health over the lifecourse. Physiol. Rev. 95, 785\u2013807 (2015).","journal-title":"Physiol. Rev."},{"key":"1031_CR42","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ng.3406","volume":"47","author":"B Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan, B. et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236\u20131241 (2015).","journal-title":"Nat. Genet."},{"key":"1031_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01261-5","volume":"8","author":"K Watanabe","year":"2017","unstructured":"Watanabe, K., Taskesen, E., van Bochoven, A. & Posthuma, D. Functional mapping and annotation of genetic associations with FUMA. Nat. Commun. 8, 1826 (2017).","journal-title":"Nat. Commun."},{"key":"1031_CR44","unstructured":"Roadmap Epigenomics Consortium et al. Integrative analysis of 111 reference human epigenomes. Nature 518, 317\u2013330 (2015)."},{"key":"1031_CR45","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu, Z. et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat. Genet. 48, 481\u2013487 (2016).","journal-title":"Nat. Genet."},{"key":"1031_CR46","doi-asserted-by":"publisher","first-page":"D793","DOI":"10.1093\/nar\/gks1055","volume":"41","author":"A Kamburov","year":"2013","unstructured":"Kamburov, A., Stelzl, U., Lehrach, H. & Herwig, R. The ConsensusPathDB interaction database: 2013 update. Nucleic Acids Res. 41, D793\u2013D800 (2013).","journal-title":"Nucleic Acids Res."}],"container-title":["Nature Human Behaviour"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41562-020-01031-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41562-020-01031-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41562-020-01031-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T20:12:33Z","timestamp":1674850353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41562-020-01031-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,18]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["1031"],"URL":"https:\/\/doi.org\/10.1038\/s41562-020-01031-2","relation":{},"ISSN":["2397-3374"],"issn-type":[{"value":"2397-3374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,18]]},"assertion":[{"value":"11 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"O.A.A. has received speaker\u2019s honorarium from Lundbeck and is a consultant to HealthLytix. A.M.D is a founder of and holds equity in CorTechs Labs, Inc. and serves on its Scientific Advisory Board. He is a member of the Scientific Advisory Board of Human Longevity, Inc. and receives funding through research agreements with General Electric Healthcare and Medtronic, Inc. The terms of these arrangements have been reviewed and approved by University of California, San Diego in accordance with its conflict of interest policies. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}