{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:36:59Z","timestamp":1791333419706,"version":"4.3.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Microbiol"],"DOI":"10.1038\/s41564-017-0076-4","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T13:23:19Z","timestamp":1512134599000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["In vivo tropism of Salmonella Typhi toxin to cells expressing a multiantennal glycan receptor"],"prefix":"10.1038","volume":"3","author":[{"given":"Yi-An","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7865-1856","authenticated-orcid":false,"given":"Andrew J.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"McBride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buyankhishig","family":"Tsogtbaatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4589-5322","authenticated-orcid":false,"given":"James C.","family":"Paulson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Nussinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingquan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6777-3505","authenticated-orcid":false,"given":"Jeongmin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"76_CR1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1146\/annurev-micro-091313-103739","volume":"68","author":"G Dougan","year":"2014","unstructured":"Dougan, G. & Baker, S. Salmonella enterica serovar Typhi and the pathogenesis of typhoid fever. Annu. Rev. Microbiol. 68, 317\u2013336 (2014).","journal-title":"Annu. Rev. Microbiol."},{"key":"76_CR2","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/S0140-6736(13)62708-7","volume":"385","author":"J Wain","year":"2015","unstructured":"Wain, J., Hendriksen, R. S., Mikoleit, M. L., Keddy, K. H. & Ochiai, R. L. Typhoid fever. Lancet 385, 1136\u20131145 (2015).","journal-title":"Lancet"},{"key":"76_CR3","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1086\/649541","volume":"50","author":"JA Crump","year":"2010","unstructured":"Crump, J. A. & Mintz, E. D. Global trends in typhoid and paratyphoid fever. Clin. Infect. Dis. 50, 241\u2013246 (2010).","journal-title":"Clin. Infect. Dis."},{"key":"76_CR4","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1128\/CMR.00002-15","volume":"28","author":"JA Crump","year":"2015","unstructured":"Crump, J. A., Sjolund-Karlsson, M., Gordon, M. A. & Parry, C. M. Epidemiology, clinical presentation, laboratory diagnosis, antimicrobial resistance, and antimicrobial management of invasive salmonella infections. Clin. Microbiol. Rev. 28, 901\u2013937 (2015).","journal-title":"Clin. Microbiol. Rev."},{"key":"76_CR5","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/j.1365-3156.1997.tb00145.x","volume":"2","author":"G Ali","year":"1997","unstructured":"Ali, G., Rashid, S., Kamli, M. A., Shah, P. A. & Allaqaband, G. Q. Spectrum of neuropsychiatric complications in 791 cases of typhoid fever. Trop. Med. Int. Health 2, 314\u2013318 (1997).","journal-title":"Trop. Med. Int. Health"},{"key":"76_CR6","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1093\/cid\/cis012","volume":"54","author":"E Lutterloh","year":"2012","unstructured":"Lutterloh, E. et al. Multidrug-resistant typhoid fever with neurologic findings on the Malawi\u2013Mozambique border. Clin. Infect. Dis. 54, 1100\u20131106 (2012).","journal-title":"Clin. Infect. Dis."},{"key":"76_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046099","volume":"7","author":"J Sejvar","year":"2012","unstructured":"Sejvar, J. et al. Neurologic manifestations associated with an outbreak of typhoid fever, Malawi\u2013Mozambique, 2009: an epidemiologic investigation. PLoS ONE 7, e46099 (2012).","journal-title":"PLoS ONE"},{"key":"76_CR8","first-page":"28","volume":"34","author":"I Szabo","year":"2013","unstructured":"Szabo, I. et al. Neurologic complications and sequellae of infectious diseases in Uganda and Kenya: analysis of 288 cases from two rural hospitals. Neuro. Endocrinol. Lett. 34, 28\u201331 (2013).","journal-title":"Neuro. Endocrinol. Lett."},{"key":"76_CR9","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature12377","volume":"499","author":"J Song","year":"2013","unstructured":"Song, J., Gao, X. & Galan, J. E. Structure and function of the Salmonella Typhi chimaeric A2B5 typhoid toxin. Nature 499, 350\u2013354 (2013).","journal-title":"Nature"},{"key":"76_CR10","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1056\/NEJM197009242831306","volume":"283","author":"RB Hornick","year":"1970","unstructured":"Hornick, R. B. et al. Typhoid fever: pathogenesis and immunologic control. New Engl. J. Med. 283, 686\u2013691 (1970).","journal-title":"New Engl. J. Med."},{"key":"76_CR11","doi-asserted-by":"publisher","first-page":"7848","DOI":"10.1016\/j.vaccine.2007.08.027","volume":"25","author":"A Fraser","year":"2007","unstructured":"Fraser, A., Paul, M., Goldberg, E., Acosta, C. J. & Leibovici, L. Typhoid fever vaccines: systematic review and meta-analysis of randomised controlled trials. Vaccine 25, 7848\u20137857 (2007).","journal-title":"Vaccine"},{"key":"76_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/srep01043","volume":"3","author":"L Liang","year":"2013","unstructured":"Liang, L. et al. Immune profiling with a Salmonella Typhi antigen microarray identifies new diagnostic biomarkers of human typhoid. Sci. Rep. 3, 1043 (2013).","journal-title":"Sci. Rep."},{"key":"76_CR13","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1128\/CVI.00104-10","volume":"17","author":"RC Charles","year":"2010","unstructured":"Charles, R. C. et al. Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology. Clin. Vaccine Immunol. 17, 1188\u20131195 (2010).","journal-title":"Clin. Vaccine Immunol."},{"key":"76_CR14","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jinf.2017.05.007","volume":"75","author":"N Tran Vu Thieu","year":"2017","unstructured":"Tran Vu Thieu, N. et al. An evaluation of purified Salmonella Typhi protein antigens for the serological diagnosis of acute typhoid fever. J. Infect. 75, 104\u2013114 (2017).","journal-title":"J. Infect."},{"key":"76_CR15","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1016\/j.cell.2014.10.057","volume":"159","author":"L Deng","year":"2014","unstructured":"Deng, L. et al. Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi. Cell 159, 1290\u20131299 (2014).","journal-title":"Cell"},{"key":"76_CR16","doi-asserted-by":"publisher","first-page":"11736","DOI":"10.1073\/pnas.182257399","volume":"99","author":"HH Chou","year":"2002","unstructured":"Chou, H. H. et al. Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution. Proc. Natl Acad. Sci. USA 99, 11736\u201311741 (2002).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"76_CR17","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.chom.2010.09.003","volume":"8","author":"J Song","year":"2010","unstructured":"Song, J. et al. A mouse model for the human pathogen Salmonella Typhi. Cell Host Microbe 8, 369\u2013376 (2010).","journal-title":"Cell Host Microbe"},{"key":"76_CR18","first-page":"283","volume":"90","author":"A Chong","year":"2017","unstructured":"Chong, A., Lee, S., Yang, Y. A. & Song, J. The role of typhoid toxin in Salmonella Typhi virulence. Yale J. Biol. Med. 90, 283\u2013290 (2017).","journal-title":"Yale J. Biol. Med."},{"key":"76_CR19","doi-asserted-by":"publisher","first-page":"4614","DOI":"10.1073\/pnas.0400932101","volume":"101","author":"E Haghjoo","year":"2004","unstructured":"Haghjoo, E. & Galan, J. E. Salmonella Typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway. Proc. Natl Acad. Sci. USA 101, 4614\u20134619 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"76_CR20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.chom.2007.11.001","volume":"3","author":"S Spano","year":"2008","unstructured":"Spano, S., Ugalde, J. E. & Galan, J. E. Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment. Cell Host Microbe 3, 30\u201338 (2008).","journal-title":"Cell Host Microbe"},{"key":"76_CR21","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.chom.2016.10.005","volume":"20","author":"SJ Chang","year":"2016","unstructured":"Chang, S. J., Song, J. & Galan, J. E. Receptor-mediated sorting of typhoid toxin during its export from Salmonella Typhi-infected cells. Cell Host Microbe 20, 682\u2013689 (2016).","journal-title":"Cell Host Microbe"},{"key":"76_CR22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0166-4328(01)00275-3","volume":"125","author":"JP Hatcher","year":"2001","unstructured":"Hatcher, J. P. et al. Development of SHIRPA to characterise the phenotype of gene-targeted mice. Behav. Brain Res. 125, 43\u201347 (2001).","journal-title":"Behav. Brain Res."},{"key":"76_CR23","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0304-3940(01)01885-7","volume":"306","author":"DC Rogers","year":"2001","unstructured":"Rogers, D. C. et al. SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice. Neurosci. Lett. 306, 89\u201392 (2001).","journal-title":"Neurosci. Lett."},{"key":"76_CR24","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/326624a0","volume":"326","author":"E Rutenber","year":"1987","unstructured":"Rutenber, E., Ready, M. & Robertus, J. D. Structure and evolution of ricin B chain. Nature 326, 624\u2013626 (1987).","journal-title":"Nature"},{"key":"76_CR25","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1093\/glycob\/cwr080","volume":"21","author":"C Geisler","year":"2011","unstructured":"Geisler, C. & Jarvis, D. L. Effective glycoanalysis with Maackia amurensis lectins requires a clear understanding of their binding specificities. Glycobiology 21, 988\u2013993 (2011).","journal-title":"Glycobiology"},{"key":"76_CR26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.chom.2016.11.004","volume":"21","author":"W Peng","year":"2017","unstructured":"Peng, W. et al. Recent H3N2 viruses have evolved specificity for extended, branched human-type receptors, conferring potential for increased avidity. Cell Host Microbe 21, 23\u201334 (2017).","journal-title":"Cell Host Microbe"},{"key":"76_CR27","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1128\/iai.57.12.3863-3868.1989","volume":"57","author":"SJ Cryz Jr","year":"1989","unstructured":"Cryz, S. J. Jr et al. Construction and characterization of a Vi-positive variant of the Salmonella Typhi live oral vaccine strain Ty21a. Infect. Immun. 57, 3863\u20133868 (1989).","journal-title":"Infect. Immun."},{"key":"76_CR28","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1128\/iai.59.9.2901-2908.1991","volume":"59","author":"JE Galan","year":"1991","unstructured":"Galan, J. E. & Curtiss, R. III Distribution of the invA, -B, -C, and -D genes of Salmonella typhimurium among other Salmonella serovars: invA mutants of Salmonella Typhi are deficient for entry into mammalian cells. Infect. Immun. 59, 2901\u20132908 (1991).","journal-title":"Infect. Immun."},{"key":"76_CR29","doi-asserted-by":"publisher","first-page":"W252","DOI":"10.1093\/nar\/gku340","volume":"42","author":"M Biasini","year":"2014","unstructured":"Biasini, M. et al. SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information. Nucleic Acids Res. 42, W252\u2013W258 (2014).","journal-title":"Nucleic Acids Res."},{"key":"76_CR30","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1002\/jcc.21886","volume":"32","author":"S Jo","year":"2011","unstructured":"Jo, S., Song, K. C., Desaire, H., MacKerell, A. D. Jr & Im, W. Glycan Reader: automated sugar identification and simulation preparation for carbohydrates and glycoproteins. J. Comput. Chem. 32, 3135\u20133141 (2011).","journal-title":"J. Comput. Chem."}],"updated-by":[{"DOI":"10.1038\/s41564-019-0505-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000}}],"container-title":["Nature Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41564-017-0076-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-017-0076-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-017-0076-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T02:34:49Z","timestamp":1671762889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41564-017-0076-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":30,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2]]}},"alternative-id":["76"],"URL":"https:\/\/doi.org\/10.1038\/s41564-017-0076-4","relation":{"correction":[{"id-type":"doi","id":"10.1038\/s41564-019-0505-7","asserted-by":"object"}]},"ISSN":["2058-5276"],"issn-type":[{"value":"2058-5276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,4]]},"assertion":[{"value":"13 April 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2019","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"An amendment to this paper has been published and can be accessed via a link at the top of the paper.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}