{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:51:52Z","timestamp":1792443112850,"version":"4.5.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T00:00:00Z","timestamp":1523232000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T00:00:00Z","timestamp":1523232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Microbiol"],"DOI":"10.1038\/s41564-018-0138-2","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T05:59:42Z","timestamp":1523599182000},"page":"611-621","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner"],"prefix":"10.1038","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3672-3780","authenticated-orcid":false,"given":"Smita","family":"Gopinath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoungjoo V.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasfia","family":"Rakib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"van Zandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha A.","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneyasu","family":"Kaisho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7824-9856","authenticated-orcid":false,"given":"Akiko","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,9]]},"reference":[{"key":"138_CR1","doi-asserted-by":"publisher","first-page":"22287","DOI":"10.1074\/jbc.M115.671222","volume":"290","author":"S Badal","year":"2015","unstructured":"Badal, S., Her, Y. F. & Maher, L. J. Nonantibiotic effects of fluoroquinolones in mammalian cells. J. Biol. Chem. 290, 22287\u201322297 (2015).","journal-title":"J. Biol. Chem."},{"key":"138_CR2","doi-asserted-by":"publisher","first-page":"192ra85","DOI":"10.1126\/scitranslmed.3006055","volume":"5","author":"S Kalghatgi","year":"2013","unstructured":"Kalghatgi, S. et al. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in mammalian cells. Sci. Transl. Med. 5, 192ra85 (2013).","journal-title":"Sci. Transl. Med."},{"key":"138_CR3","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1016\/j.celrep.2015.02.034","volume":"10","author":"N Moullan","year":"2015","unstructured":"Moullan, N. et al. Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research. Cell Rep. 10, 1681\u20131691 (2015).","journal-title":"Cell Rep."},{"key":"138_CR4","doi-asserted-by":"crossref","unstructured":"Yang, J. H. et al. Antibiotic-induced changes to the host metabolic environment inhibit drug efficacy and alter immune function. Cell Host Microbe 22, 757\u2013765.","DOI":"10.1016\/j.chom.2017.10.020"},{"key":"138_CR5","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1128\/JVI.78.5.2530-2536.2004","volume":"78","author":"MM Linehan","year":"2004","unstructured":"Linehan, M. M. et al. In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa. J. Virol. 78, 2530\u20132536 (2004).","journal-title":"J. Virol."},{"key":"138_CR6","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.it.2013.08.001","volume":"34","author":"H Shin","year":"2013","unstructured":"Shin, H. & Iwasaki, A. Generating protective immunity against genital herpes. Trends Immunol. 34, 487\u2013494 (2013).","journal-title":"Trends Immunol."},{"key":"138_CR7","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/nm.3103","volume":"19","author":"L Corey","year":"2013","unstructured":"Corey, L. & Schiffer, J. T. Rapid host immune response and viral dynamics in herpes simplex virus-2 infection. Nat. Med. 19, 280\u2013290 (2013).","journal-title":"Nat. Med."},{"key":"138_CR8","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.chom.2016.05.008","volume":"19","author":"W Khoury-Hanold","year":"2016","unstructured":"Khoury-Hanold, W. et al. Viral spread to enteric neurons links genital HSV-1 infection to toxic megacolon and lethality. Cell Host Microbe 19, 788\u2013799 (2016).","journal-title":"Cell Host Microbe"},{"key":"138_CR9","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1128\/jvi.51.3.747-753.1984","volume":"51","author":"MR McDermott","year":"1984","unstructured":"McDermott, M. R. et al. Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2. J. Virol. 51, 747\u2013753 (1984).","journal-title":"J. Virol."},{"key":"138_CR10","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1021\/cr0404085","volume":"105","author":"GF Busscher","year":"2005","unstructured":"Busscher, G. F., Rutjes, F. P. J. T. & van Delft, F. L. 2-Deoxystreptamine: central scaffold of aminoglycoside antibiotics. Chem. Rev. 105, 775\u2013792 (2005).","journal-title":"Chem. Rev."},{"key":"138_CR11","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/nrmicro3155","volume":"12","author":"DN Wilson","year":"2014","unstructured":"Wilson, D. N. Ribosome-targeting antibiotics and mechanisms of bacterial resistance. Nat. Rev. Microbiol. 12, 35\u201348 (2014).","journal-title":"Nat. Rev. Microbiol."},{"key":"138_CR12","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1136\/gutjnl-2014-308820","volume":"64","author":"A Morgun","year":"2015","unstructured":"Morgun, A. et al. Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks. Gut 64, 1732\u20131743 (2015).","journal-title":"Gut"},{"key":"138_CR13","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1128\/jvi.62.7.2386-2393.1988","volume":"62","author":"E Meier","year":"1988","unstructured":"Meier, E. et al. A family of interferon-induced Mx-related mRNAs encodes cytoplasmic and nuclear proteins in rat cells. J. Virol. 62, 2386\u20132393 (1988).","journal-title":"J. Virol."},{"key":"138_CR14","doi-asserted-by":"publisher","first-page":"4518","DOI":"10.1128\/MCB.8.10.4518","volume":"8","author":"P Staeheli","year":"1988","unstructured":"Staeheli, P., Grob, R., Meier, E., Sutcliffe, J. G. & Haller, O. Influenza virus-susceptible mice carry Mx genes with a large deletion or a nonsense mutation. Mol. Cell. Biol. 8, 4518\u20134523 (1988).","journal-title":"Mol. Cell. Biol."},{"key":"138_CR15","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.tim.2014.12.003","volume":"23","author":"O Haller","year":"2015","unstructured":"Haller, O., Staeheli, P., Schwemmle, M. & Kochs, G. Mx GTPases: dynamin-like antiviral machines of innate immunity. Trends Microbiol. 23, 154\u2013163 (2015).","journal-title":"Trends Microbiol."},{"key":"138_CR16","doi-asserted-by":"publisher","first-page":"5354","DOI":"10.1073\/pnas.1019378108","volume":"108","author":"T Ichinohe","year":"2011","unstructured":"Ichinohe, T. et al. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proc. Natl Acad. Sci. USA 108, 5354\u20135359 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"138_CR17","doi-asserted-by":"publisher","first-page":"6806","DOI":"10.1073\/pnas.0701849104","volume":"104","author":"D Grimm","year":"2007","unstructured":"Grimm, D. et al. Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene. Proc. Natl Acad. Sci. USA 104, 6806\u20136811 (2007).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"138_CR18","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1016\/j.cell.2016.08.004","volume":"166","author":"LJ Yockey","year":"2016","unstructured":"Yockey, L. J. et al. Vaginal exposure to Zika virus during pregnancy leads to fetal brain infection. Cell 166, 1247\u20131256 (2016).","journal-title":"Cell"},{"key":"138_CR19","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1126\/science.1087262","volume":"301","author":"M Yamamoto","year":"2003","unstructured":"Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640\u2013643 (2003).","journal-title":"Science"},{"key":"138_CR20","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/nature03464","volume":"434","author":"K Honda","year":"2005","unstructured":"Honda, K. et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434, 772\u2013777 (2005).","journal-title":"Nature"},{"key":"138_CR21","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","volume":"32","author":"WM Schneider","year":"2014","unstructured":"Schneider, W. M., Chevillotte, M. D. & Rice, C. M. Interferon-stimulated genes: a complex web of host defenses. Annu. Rev. Immunol. 32, 513\u2013545 (2014).","journal-title":"Annu. Rev. Immunol."},{"key":"138_CR22","doi-asserted-by":"publisher","first-page":"42013","DOI":"10.1074\/jbc.M110.165936","volume":"285","author":"S Schmid","year":"2010","unstructured":"Schmid, S., Mordstein, M., Kochs, G., Garcia-Sastre, A. & tenOever, B. R. Transcription factor redundancy ensures induction of the antiviral state. J. Biol. Chem. 285, 42013\u201342022 (2010).","journal-title":"J. Biol. Chem."},{"key":"138_CR23","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1126\/science.1257530","volume":"346","author":"N Iijima","year":"2014","unstructured":"Iijima, N. & Iwasaki, A. T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. Science 346, 93\u201398 (2014).","journal-title":"Science"},{"key":"138_CR24","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.0105-2896.2009.00870.x","volume":"234","author":"K Shortman","year":"2010","unstructured":"Shortman, K. & Heath, W. R. The CD8+ dendritic cell subset. Immunol. Rev. 234, 18\u201331 (2010).","journal-title":"Immunol. Rev."},{"key":"138_CR25","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/nature03326","volume":"433","author":"O Schulz","year":"2005","unstructured":"Schulz, O. et al. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 433, 887\u2013892 (2005).","journal-title":"Nature"},{"key":"138_CR26","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/ni1008-1091","volume":"9","author":"TSP Heng","year":"2008","unstructured":"Heng, T. S. P. et al. The Immunological Genome Project: networks of gene expression in immune cells. Nat. Immunol. 9, 1091\u20131094 (2008).","journal-title":"Nat. Immunol."},{"key":"138_CR27","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/ni.2370","volume":"13","author":"JC Miller","year":"2012","unstructured":"Miller, J. C. et al. Deciphering the transcriptional network of the dendritic cell lineage. Nat. Immunol. 13, 888\u2013899 (2012).","journal-title":"Nat. Immunol."},{"key":"138_CR28","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.4049\/jimmunol.1101717","volume":"187","author":"K Crozat","year":"2011","unstructured":"Crozat, K. et al. Cutting edge: expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8+ type. J. Immunol. 187, 4411\u20134415 (2011).","journal-title":"J. Immunol."},{"key":"138_CR29","doi-asserted-by":"publisher","first-page":"6071","DOI":"10.4049\/jimmunol.1202798","volume":"190","author":"C Yamazaki","year":"2013","unstructured":"Yamazaki, C. et al. Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1. J. Immunol. 190, 6071\u20136082 (2013).","journal-title":"J. Immunol."},{"key":"138_CR30","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/j.1365-2125.1995.tb05719.x","volume":"39","author":"EJ Begg","year":"1995","unstructured":"Begg, E. J. & Barclay, M. L. Aminoglycosides\u201450 years on. Br. J. Clin. Pharmacol. 39, 597\u2013603 (1995).","journal-title":"Br. J. Clin. Pharmacol."},{"key":"138_CR31","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1097\/MOO.0b013e3282ef772d","volume":"15","author":"MD Rizzi","year":"2007","unstructured":"Rizzi, M. D. & Hirose, K. Aminoglycoside ototoxicity. Curr. Opin. Otolaryngol. Head Neck Surg. 15, 352\u2013357 (2007).","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"138_CR32","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/neu.20054","volume":"61","author":"JI Matsui","year":"2004","unstructured":"Matsui, J. I., Gale, J. E. & Warchol, M. E. Critical signaling events during the aminoglycoside-induced death of sensory hair cells in vitro. J. Neurobiol. 61, 250\u2013266 (2004).","journal-title":"J. Neurobiol."},{"key":"138_CR33","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/01.moo.0000186799.45377.63","volume":"13","author":"AG Cheng","year":"2005","unstructured":"Cheng, A. G., Cunningham, L. L. & Rubel, E. W. Mechanisms of hair cell death and protection. Curr. Opin. Otolaryngol. Head. Neck Surg. 13, 343\u2013348 (2005).","journal-title":"Curr. Opin. Otolaryngol. Head. Neck Surg."},{"key":"138_CR34","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1177\/0897190014546836","volume":"27","author":"KA Wargo","year":"2014","unstructured":"Wargo, K. A. & Edwards, J. D. Aminoglycoside-induced nephrotoxicity. J. Pharm. Pract. 27, 573\u2013577 (2014).","journal-title":"J. Pharm. Pract."},{"key":"138_CR35","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1016\/0006-2952(90)90078-Y","volume":"40","author":"G Laurent","year":"1990","unstructured":"Laurent, G., Kishore, B. K. & Tulkens, P. M. Aminoglycoside-induced renal phospholipidosis and nephrotoxicity. Biochem. Pharmacol. 40, 2383\u20132392 (1990).","journal-title":"Biochem. Pharmacol."},{"key":"138_CR36","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1016\/S0968-0896(01)00034-7","volume":"9","author":"DH Ryu","year":"2001","unstructured":"Ryu, D. H. & Rando, R. R. Aminoglycoside binding to human and bacterial A-site rRNA decoding region constructs. Bioorg. Med. Chem. 9, 2601\u20132608 (2001).","journal-title":"Bioorg. Med. Chem."},{"key":"138_CR37","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1006\/jmbi.1996.0526","volume":"262","author":"MI Recht","year":"1996","unstructured":"Recht, M. I., Fourmy, D., Blanchard, S. C., Dahlquist, K. D. & Puglisi, J. D. RNA sequence determinants for aminoglycoside binding to an A-site rRNA model oligonucleotide. J. Mol. Biol. 262, 421\u2013436 (1996).","journal-title":"J. Mol. Biol."},{"key":"138_CR38","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/S1367-5931(99)00028-9","volume":"3","author":"F Walter","year":"1999","unstructured":"Walter, F., Vicens, Q. & Westhof, E. Aminoglycoside\u2013RNA interactions. Curr. Opin. Chem. Biol. 3, 694\u2013704 (1999).","journal-title":"Curr. Opin. Chem. Biol."},{"key":"138_CR39","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.celrep.2016.12.068","volume":"18","author":"K Rausch","year":"2017","unstructured":"Rausch, K. et al. Screening bioactives reveals nanchangmycin as a broad spectrum antiviral active against Zika virus. Cell Rep. 18, 804\u2013815 (2017).","journal-title":"Cell Rep."},{"key":"138_CR40","doi-asserted-by":"publisher","first-page":"14408","DOI":"10.1073\/pnas.1618029113","volume":"113","author":"H Retallack","year":"2016","unstructured":"Retallack, H. et al. Zika virus cell tropism in the developing human brain and inhibition by azithromycin. Proc. Natl Acad. Sci. USA 113, 14408\u201314413 (2016).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"138_CR41","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.1093\/jac\/dkw222","volume":"71","author":"JD Porter","year":"2016","unstructured":"Porter, J. D. et al. Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium. J. Antimicrob. Chemother. 71, 2767\u20132781 (2016).","journal-title":"J. Antimicrob. Chemother."},{"key":"138_CR42","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1038\/nm.3708","volume":"20","author":"A Sistigu","year":"2014","unstructured":"Sistigu, A. et al. Cancer cell\u2013autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat. Med. 20, 1301\u20131309 (2014).","journal-title":"Nat. Med."},{"key":"138_CR43","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0006-8993(95)01198-6","volume":"704","author":"E Hashino","year":"1995","unstructured":"Hashino, E. & Shero, M. Endocytosis of aminoglycoside antibiotics in sensory hair cells. Brain Res. 704, 135\u2013140 (1995).","journal-title":"Brain Res."},{"key":"138_CR44","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.heares.2005.02.005","volume":"204","author":"SE Myrdal","year":"2005","unstructured":"Myrdal, S. E. & Steyger, P. S. TRPV1 regulators mediate gentamicin penetration of cultured kidney cells. Hear. Res. 204, 170\u2013182 (2005).","journal-title":"Hear. Res."},{"key":"138_CR45","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/imm.12562","volume":"147","author":"BM Assas","year":"2016","unstructured":"Assas, B. M., Wakid, M. H., Zakai, H. A., Miyan, J. A. & Pennock, J. L. Transient receptor potential vanilloid 1 expression and function in splenic dendritic cells: a potential role in immune homeostasis. Immunology 147, 292\u2013304 (2016).","journal-title":"Immunology"},{"key":"138_CR46","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1172\/JCI118176","volume":"96","author":"SK Moestrup","year":"1995","unstructured":"Moestrup, S. K. et al. Evidence that epithelial glycoprotein 330\/megalin mediates uptake of polybasic drugs. J. Clin. Invest. 96, 1404\u20131413 (1995).","journal-title":"J. Clin. Invest."},{"key":"138_CR47","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/nrm778","volume":"3","author":"EI Christensen","year":"2002","unstructured":"Christensen, E. I. & Birn, H. Megalin and cubilin: multifunctional endocytic receptors. Nat. Rev. Mol. Cell Biol. 3, 258\u2013268 (2002).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"138_CR48","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1084\/jem.20020161","volume":"195","author":"T Iyoda","year":"2002","unstructured":"Iyoda, T. et al. The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J. Exp. Med. 195, 1289\u20131302 (2002).","journal-title":"J. Exp. Med."},{"key":"138_CR49","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/ni.1724","volume":"10","author":"S Bedoui","year":"2009","unstructured":"Bedoui, S. et al. Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat. Immunol. 10, 488\u2013495 (2009).","journal-title":"Nat. Immunol."},{"key":"138_CR50","doi-asserted-by":"publisher","first-page":"19273","DOI":"10.1074\/jbc.M115.655092","volume":"290","author":"S Hong","year":"2015","unstructured":"Hong, S. et al. Evidence that antibiotics bind to human mitochondrial ribosomal RNA has implications for aminoglycoside toxicity. J. Biol. Chem. 290, 19273\u201319286 (2015).","journal-title":"J. Biol. Chem."},{"key":"138_CR51","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.immuni.2006.04.004","volume":"24","author":"Q Sun","year":"2006","unstructured":"Sun, Q. et al. The specific and essential role of MAVS in antiviral innate immune responses. Immunity 24, 633\u2013642 (2006).","journal-title":"Immunity"},{"key":"138_CR52","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1073\/pnas.80.7.1910","volume":"80","author":"MA Horisberger","year":"1983","unstructured":"Horisberger, M. A., Staeheli, P. & Haller, O. Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus. Proc. Natl Acad. Sci. USA 80, 1910\u20131914 (1983).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"138_CR53","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature11522","volume":"491","author":"H Shin","year":"2012","unstructured":"Shin, H. & Iwasaki, A. A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature 491, 463\u2013467 (2012).","journal-title":"Nature"},{"key":"138_CR54","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","volume":"30","author":"R Edgar","year":"2002","unstructured":"Edgar, R., Domrachev, M. & Lash, A. E. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30, 207\u2013210 (2002).","journal-title":"Nucleic Acids Res."}],"container-title":["Nature Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41564-018-0138-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-018-0138-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-018-0138-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T18:49:09Z","timestamp":1671562149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41564-018-0138-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,9]]},"references-count":54,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5]]}},"alternative-id":["138"],"URL":"https:\/\/doi.org\/10.1038\/s41564-018-0138-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/248617","asserted-by":"object"}],"has-review":[{"id-type":"doi","id":"10.3410\/f.733028927.793557686","asserted-by":"object"}]},"ISSN":["2058-5276"],"issn-type":[{"value":"2058-5276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,9]]},"assertion":[{"value":"21 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}