{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:43:08Z","timestamp":1793086988764,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Microbiol"],"DOI":"10.1038\/s41564-018-0288-2","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T14:06:46Z","timestamp":1541686006000},"page":"216-225","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility"],"prefix":"10.1038","volume":"4","author":[{"given":"Corina","family":"Beerli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Yakimovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1162-6549","authenticated-orcid":false,"given":"Samuel","family":"Kilcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glennys V.","family":"Reynoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-6905","authenticated-orcid":false,"given":"Gotthold","family":"Fl\u00e4schner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather D.","family":"Hickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1466-9541","authenticated-orcid":false,"given":"Jason","family":"Mercer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"288_CR1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1128\/JVI.72.2.1235-1243.1998","volume":"72","author":"CM Sanderson","year":"1998","unstructured":"Sanderson, C. M., Way, M. & Smith, G. L. Virus-induced cell motility. J. Virol. 72, 1235\u20131243 (1998).","journal-title":"J. Virol."},{"key":"288_CR2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1126\/science.1122411","volume":"311","author":"F Valderrama","year":"2006","unstructured":"Valderrama, F., Cordeiro, J. V., Schleich, S., Frischknecht, F. & Way, M. Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling. Science 311, 377\u2013381 (2006).","journal-title":"Science"},{"key":"288_CR3","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ceb.2015.08.005","volume":"36","author":"AJ Ridley","year":"2015","unstructured":"Ridley, A. J. Rho GTPase signalling in cell migration. Curr. Opin. Cell Biol. 36, 103\u2013112 (2015).","journal-title":"Curr. Opin. Cell Biol."},{"key":"288_CR4","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/nrc1075","volume":"3","author":"P Friedl","year":"2003","unstructured":"Friedl, P. & Wolf, K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat. Rev. Cancer 3, 362\u2013374 (2003).","journal-title":"Nat. Rev. Cancer"},{"key":"288_CR5","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1242\/dev.101451","volume":"141","author":"G Reig","year":"2014","unstructured":"Reig, G., Pulgar, E. & Concha, M. L. Cell migration: from tissue culture to embryos. Development 141, 1999\u20132013 (2014).","journal-title":"Development"},{"key":"288_CR6","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.chom.2011.10.011","volume":"10","author":"F Cheng","year":"2011","unstructured":"Cheng, F. et al. KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition. Cell Host Microbe 10, 577\u2013590 (2011).","journal-title":"Cell Host Microbe"},{"key":"288_CR7","doi-asserted-by":"publisher","first-page":"7921","DOI":"10.1128\/JVI.01172-13","volume":"87","author":"F Abaitua","year":"2013","unstructured":"Abaitua, F., Zia, F. R., Hollinshead, M. & O\u2019Hare, P. Polarized cell migration during cell-to-cell transmission of herpes simplex virus in human skin keratinocytes. J. Virol. 87, 7921\u20137932 (2013).","journal-title":"J. Virol."},{"key":"288_CR8","doi-asserted-by":"publisher","first-page":"3654","DOI":"10.1128\/JVI.01888-07","volume":"82","author":"CW Dawson","year":"2008","unstructured":"Dawson, C. W., Laverick, L., Morris, M. A., Tramoutanis, G. & Young, L. S. Epstein\u2013Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK\u2013MAPK pathway. J. Virol. 82, 3654\u20133664 (2008).","journal-title":"J. Virol."},{"key":"288_CR9","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1038\/sj.onc.1210916","volume":"27","author":"N Kivi","year":"2008","unstructured":"Kivi, N., Greco, D., Auvinen, P. & Auvinen, E. Genes involved in cell adhesion, cell motility and mitogenic signaling are altered due to HPV 16 E5 protein expression. Oncogene 27, 2532\u20132541 (2008).","journal-title":"Oncogene"},{"key":"288_CR10","doi-asserted-by":"publisher","first-page":"7167","DOI":"10.1128\/JVI.06936-11","volume":"86","author":"CR Irwin","year":"2012","unstructured":"Irwin, C. R. & Evans, D. H. Modulation of the myxoma virus plaque phenotype by vaccinia virus protein F11. J. Virol. 86, 7167\u20137179 (2012).","journal-title":"J. Virol."},{"key":"288_CR11","doi-asserted-by":"publisher","first-page":"e8506","DOI":"10.1371\/journal.pone.0008506","volume":"4","author":"JV Cordeiro","year":"2009","unstructured":"Cordeiro, J. V. et al. F11-mediated inhibition of RhoA signalling enhances the spread of vaccinia virus in vitro and in vivo in an intranasal mouse model of infection. PLoS ONE 4, e8506 (2009).","journal-title":"PLoS ONE"},{"key":"288_CR12","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.chom.2013.06.006","volume":"14","author":"Y Handa","year":"2013","unstructured":"Handa, Y., Durkin, C. H., Dodding, M. P. & Way, M. Vaccinia virus F11 promotes viral spread by acting as a PDZ-containing scaffolding protein to bind myosin-9A and inhibit RhoA signaling. Cell Host Microbe 14, 51\u201362 (2013).","journal-title":"Cell Host Microbe"},{"key":"288_CR13","unstructured":"McFadden, G. & Moyer, R. in Cytokine Reference (eds Oppenheim, J. J. & Feldmann, M.) 841\u2013846 (Academic Press, San Diego, 2000)."},{"key":"288_CR14","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1128\/jvi.62.3.1080-1083.1988","volume":"62","author":"W Chang","year":"1988","unstructured":"Chang, W., Lim, J. G., Hellstrom, I. & Gentry, L. E. Characterization of vaccinia virus growth factor biosynthetic pathway with an antipeptide antiserum. J. Virol. 62, 1080\u20131083 (1988).","journal-title":"J. Virol."},{"key":"288_CR15","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1128\/MCB.6.1.332","volume":"6","author":"CS King","year":"1986","unstructured":"King, C. S., Cooper, J. A., Moss, B. & Twardzik, D. R. Vaccinia virus growth factor stimulates tyrosine protein kinase activity of A431 cell epidermal growth factor receptors. Mol. Cell. Biol. 6, 332\u2013336 (1986).","journal-title":"Mol. Cell. Biol."},{"key":"288_CR16","doi-asserted-by":"publisher","first-page":"5300","DOI":"10.1073\/pnas.82.16.5300","volume":"82","author":"DR Twardzik","year":"1985","unstructured":"Twardzik, D. R., Brown, J. P., Ranchalis, J. E., Todaro, G. J. & Moss, B. Vaccinia virus-infected cells release a novel polypeptide functionally related to transforming and epidermal growth factors. Proc. Natl Acad. Sci. USA 82, 5300\u20135304 (1985).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"288_CR17","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S0092-8674(85)80133-1","volume":"42","author":"P Stroobant","year":"1985","unstructured":"Stroobant, P. et al. Purification and characterization of vaccinia virus growth factor. Cell 42, 383\u2013393 (1985).","journal-title":"Cell"},{"key":"288_CR18","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1128\/jvi.62.3.866-874.1988","volume":"62","author":"RM Buller","year":"1988","unstructured":"Buller, R. M., Chakrabarti, S., Cooper, J. A., Twardzik, D. R. & Moss, B. Deletion of the vaccinia virus growth factor gene reduces virus virulence. J. Virol. 62, 866\u2013874 (1988).","journal-title":"J. Virol."},{"key":"288_CR19","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0882-4010(89)90071-5","volume":"6","author":"AC Lai","year":"1989","unstructured":"Lai, A. C. & Pogo, B. G. Attenuated deletion mutants of vaccinia virus lacking the vaccinia growth factor are defective in replication in vivo. Microb. Pathog. 6, 219\u2013226 (1989).","journal-title":"Microb. Pathog."},{"key":"288_CR20","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/0042-6822(88)90635-6","volume":"164","author":"RM Buller","year":"1988","unstructured":"Buller, R. M., Chakrabarti, S., Moss, B. & Fredrickson, T. Cell proliferative response to vaccinia virus is mediated by VGF. Virology 164, 182\u2013192 (1988).","journal-title":"Virology"},{"key":"288_CR21","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/ni1557","volume":"9","author":"HD Hickman","year":"2008","unstructured":"Hickman, H. D. et al. Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes. Nat. Immunol. 9, 155\u2013165 (2008).","journal-title":"Nat. Immunol."},{"key":"288_CR22","doi-asserted-by":"publisher","first-page":"4800","DOI":"10.3390\/v7082844","volume":"7","author":"SR Bidgood","year":"2015","unstructured":"Bidgood, S. R. & Mercer, J. Cloak and dagger: alternative immune evasion and modulation strategies of poxviruses. Viruses 7, 4800\u20134825 (2015).","journal-title":"Viruses"},{"key":"288_CR23","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1111\/j.1462-5822.2009.01327.x","volume":"11","author":"A Postigo","year":"2009","unstructured":"Postigo, A., Martin, M. C., Dodding, M. P. & Way, M. Vaccinia-induced epidermal growth factor receptor\u2013MEK signalling and the anti-apoptotic protein F1L synergize to suppress cell death during infection. Cell. Microbiol. 11, 1208\u20131218 (2009).","journal-title":"Cell. Microbiol."},{"key":"288_CR24","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1042\/BJ20031375","volume":"381","author":"AA Andrade","year":"2004","unstructured":"Andrade, A. A. et al. The vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication. Biochem. J. 381, 437\u2013446 (2004).","journal-title":"Biochem. J."},{"key":"288_CR25","doi-asserted-by":"publisher","first-page":"5948","DOI":"10.1093\/emboj\/17.20.5948","volume":"17","author":"E Tzahar","year":"1998","unstructured":"Tzahar, E. et al. Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network. EMBO J. 17, 5948\u20135963 (1998).","journal-title":"EMBO J."},{"key":"288_CR26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1006\/viro.1995.9958","volume":"214","author":"HS Kim","year":"1995","unstructured":"Kim, H. S. et al. Tyrosine phosphorylation of phospholipase C-\u03b31 by vaccinia virus growth factor. Virology 214, 21\u201328 (1995).","journal-title":"Virology"},{"key":"288_CR27","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.virol.2016.12.011","volume":"507","author":"CA Bonjardim","year":"2017","unstructured":"Bonjardim, C. A. Viral exploitation of the MEK\/ERK pathway\u2014a tale of vaccinia virus and other viruses. Virology 507, 267\u2013275 (2017).","journal-title":"Virology"},{"key":"288_CR28","doi-asserted-by":"publisher","first-page":"4619","DOI":"10.1242\/jcs.01481","volume":"117","author":"C Huang","year":"2004","unstructured":"Huang, C., Jacobson, K. & Schaller, M. D. MAP kinases and cell migration. J. Cell Sci. 117, 4619\u20134628 (2004).","journal-title":"J. Cell Sci."},{"key":"288_CR29","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.antiviral.2010.11.006","volume":"89","author":"S Langhammer","year":"2011","unstructured":"Langhammer, S., Koban, R., Yue, C. & Ellerbrok, H. Inhibition of poxvirus spreading by the anti-tumor drug gefitinib (Iressa). Antiviral Res. 89, 64\u201370 (2011).","journal-title":"Antiviral Res."},{"key":"288_CR30","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1128\/JVI.06166-11","volume":"86","author":"M Schweneker","year":"2012","unstructured":"Schweneker, M. et al. The vaccinia virus O1 protein is required for sustained activation of extracellular signal-regulated kinase 1\/2 and promotes viral virulence. J. Virol. 86, 2323\u20132336 (2012).","journal-title":"J. Virol."},{"key":"288_CR31","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/j.cellsig.2005.03.026","volume":"17","author":"AB Singh","year":"2005","unstructured":"Singh, A. B. & Harris, R. C. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Cell. Signal. 17, 1183\u20131193 (2005).","journal-title":"Cell. Signal."},{"key":"288_CR32","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/nrm1548","volume":"6","author":"CP Blobel","year":"2005","unstructured":"Blobel, C. P. ADAMs: key components in EGFR signalling and development. Nat. Rev. Mol. Cell Biol. 6, 32\u201343 (2005).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"288_CR33","doi-asserted-by":"publisher","first-page":"161","DOI":"10.2174\/1386207053258488","volume":"8","author":"A Ludwig","year":"2005","unstructured":"Ludwig, A. et al. Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules. Comb. Chem. High Throughput Screen. 8, 161\u2013171 (2005).","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"288_CR34","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/378636a0","volume":"378","author":"S Cudmore","year":"1995","unstructured":"Cudmore, S., Cossart, P., Griffiths, G. & Way, M. Actin-based motility of vaccinia virus. Nature 378, 636\u2013638 (1995).","journal-title":"Nature"},{"key":"288_CR35","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1126\/science.1183173","volume":"327","author":"V Doceul","year":"2010","unstructured":"Doceul, V., Hollinshead, M., van der Linden, L. & Smith, G. L. Repulsion of superinfecting virions: a mechanism for rapid virus spread. Science 327, 873\u2013876 (2010).","journal-title":"Science"},{"key":"288_CR36","doi-asserted-by":"publisher","first-page":"e00078-15","DOI":"10.1128\/mSphere.00078-15","volume":"1","author":"A Yakimovich","year":"2016","unstructured":"Yakimovich, A. et al. Infection: a generic framework for computational simulation of virus transmission between cells. mSphere 1, e00078-15 (2016).","journal-title":"mSphere"},{"key":"288_CR37","doi-asserted-by":"publisher","first-page":"11673","DOI":"10.3748\/wjg.v21.i41.11673","volume":"21","author":"M Yang","year":"2015","unstructured":"Yang, M. & Huang, C. Z. Mitogen-activated protein kinase signaling pathway and invasion and metastasis of gastric cancer. World J. Gastroenterol. 21, 11673\u201311679 (2015).","journal-title":"World J. Gastroenterol."},{"key":"288_CR38","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1099\/0022-1317-50-1-89","volume":"50","author":"LG Payne","year":"1980","unstructured":"Payne, L. G. Significance of extracellular enveloped virus in the in vitro and in vivo dissemination of vaccinia. J. Gen. Virol. 50, 89\u2013100 (1980).","journal-title":"J. Gen. Virol."},{"key":"288_CR39","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1172\/JCI200523220","volume":"115","author":"H Yang","year":"2005","unstructured":"Yang, H. et al. Antiviral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction. J. Clin. Invest. 115, 379\u2013387 (2005).","journal-title":"J. Clin. Invest."},{"key":"288_CR40","doi-asserted-by":"publisher","first-page":"6260","DOI":"10.1128\/JVI.79.10.6260-6271.2005","volume":"79","author":"L Aldaz-Carroll","year":"2005","unstructured":"Aldaz-Carroll, L. et al. Epitope-mapping studies define two major neutralization sites on the vaccinia virus extracellular enveloped virus glycoprotein B5R. J. Virol. 79, 6260\u20136271 (2005).","journal-title":"J. Virol."},{"key":"288_CR41","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1126\/science.1155164","volume":"320","author":"J Mercer","year":"2008","unstructured":"Mercer, J. & Helenius, A. Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells. Science 320, 531\u2013535 (2008).","journal-title":"Science"},{"key":"288_CR42","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ymeth.2016.09.016","volume":"115","author":"JY Tinevez","year":"2017","unstructured":"Tinevez, J. Y. et al. TrackMate: an open and extensible platform for single-particle tracking. Methods 115, 80\u201390 (2017).","journal-title":"Methods"},{"key":"288_CR43","doi-asserted-by":"publisher","first-page":"e0138760","DOI":"10.1371\/journal.pone.0138760","volume":"10","author":"A Yakimovich","year":"2015","unstructured":"Yakimovich, A. et al. Plaque2.0\u2014a high-throughput analysis framework to score virus\u2013cell transmission and clonal cell expansion. PLoS ONE 10, e0138760 (2015).","journal-title":"PLoS ONE"},{"key":"288_CR44","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/A:1010933404324","volume":"45","author":"L Breiman","year":"2001","unstructured":"Breiman, L. Random forests. Mach. Learn. 45, 5\u201332 (2001).","journal-title":"Mach. Learn."},{"key":"288_CR45","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1093\/bioinformatics\/btx180","volume":"33","author":"I Arganda-Carreras","year":"2017","unstructured":"Arganda-Carreras, I. et al. Trainable Weka Segmentation: a machine learning tool for microscopy pixel classification. Bioinformatics 33, 2424\u20132426 (2017).","journal-title":"Bioinformatics"},{"key":"288_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1214\/aos\/1176344552","volume":"7","author":"B Efron","year":"1979","unstructured":"Efron, B. Bootstrap methods: another look at the jackknife. Ann. Stat. 7, 1\u201326 (1979).","journal-title":"Ann. Stat."},{"key":"288_CR47","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/cgf.12107","volume":"32","author":"N Ferreira","year":"2013","unstructured":"Ferreira, N., Klosowski, J. T., Scheidegger, C. E. & Silva, C. T. Vector field k-means: clustering trajectories by fitting multiple vector fields. Comput. Graph. Forum 32, 201\u2013210 (2013).","journal-title":"Comput. Graph. Forum"},{"key":"288_CR48","doi-asserted-by":"publisher","first-page":"e1005493","DOI":"10.1371\/journal.ppat.1005493","volume":"12","author":"SS Cush","year":"2016","unstructured":"Cush, S. S. et al. Locally produced IL-10 limits cutaneous vaccinia virus spread. PLoS Pathog. 12, e1005493 (2016).","journal-title":"PLoS Pathog."},{"key":"288_CR49","doi-asserted-by":"publisher","first-page":"365","DOI":"10.4081\/1749","volume":"46","author":"L Pieri","year":"2002","unstructured":"Pieri, L., Sassoli, C., Romagnoli, P. & Domenici, L. Use of periodate-lysine-paraformaldehyde for the fixation of multiple antigens in human skin biopsies. Eur. J. Histochem. 46, 365\u2013375 (2002).","journal-title":"Eur. J. Histochem."}],"container-title":["Nature Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41564-018-0288-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-018-0288-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-018-0288-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T17:54:35Z","timestamp":1684864475000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41564-018-0288-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,12]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2]]}},"alternative-id":["288"],"URL":"https:\/\/doi.org\/10.1038\/s41564-018-0288-2","relation":{},"ISSN":["2058-5276"],"issn-type":[{"value":"2058-5276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,12]]},"assertion":[{"value":"22 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}