{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:49:51Z","timestamp":1787003391377,"version":"build-2736575974"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Microbiol"],"DOI":"10.1038\/s41564-019-0484-8","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T12:04:27Z","timestamp":1562587467000},"page":"1516-1531","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["CYRI\/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection"],"prefix":"10.1038","volume":"4","author":[{"given":"Kyoko E.","family":"Yuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1249-2765","authenticated-orcid":false,"given":"Hadir","family":"Marei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenij","family":"Fiskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"Eva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica A.","family":"Gopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6183-2092","authenticated-orcid":false,"given":"Jeremy A.","family":"Schwartzentruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Majewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Cellier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6512-3437","authenticated-orcid":false,"given":"Judith N.","family":"Mandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia M.","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3980-6610","authenticated-orcid":false,"given":"Danielle","family":"Malo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8156-9511","authenticated-orcid":false,"given":"Ivan","family":"Dikic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"484_CR1","doi-asserted-by":"publisher","first-page":"e1001921","DOI":"10.1371\/journal.pmed.1001921","volume":"12","author":"MD Kirk","year":"2015","unstructured":"Kirk, M. D. et al. World Health Organization estimates of the global and regional disease burden of 22 foodborne bacterial, protozoal, and viral diseases, 2010: a data synthesis. PLoS Med. 12, e1001921 (2015).","journal-title":"PLoS Med."},{"key":"484_CR2","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1086\/650733","volume":"50","author":"SE Majowicz","year":"2010","unstructured":"Majowicz, S. E. et al. The global burden of nontyphoidal Salmonella gastroenteritis. Clin. Infect. Dis. 50, 882\u2013889 (2010).","journal-title":"Clin. Infect. Dis."},{"key":"484_CR3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1179\/2047773215Y.0000000030","volume":"109","author":"F Prestinaci","year":"2015","unstructured":"Prestinaci, F., Pezzotti, P. & Pantosti, A. Antimicrobial resistance: a global multifaceted phenomenon. Pathog. Glob. Health 109, 309\u2013318 (2015).","journal-title":"Pathog. Glob. Health"},{"key":"484_CR4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nrmicro3420","volume":"13","author":"DL LaRock","year":"2015","unstructured":"LaRock, D. L., Chaudhary, A. & Miller, S. I. Salmonellae interactions with host processes. Nat. Rev. Microbiol. 13, 191\u2013205 (2015).","journal-title":"Nat. Rev. Microbiol."},{"key":"484_CR5","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.mib.2005.12.006","volume":"9","author":"MC Schlumberger","year":"2006","unstructured":"Schlumberger, M. C. & Hardt, W. D. Salmonella type III secretion effectors: pulling the host cell\u2019s strings. Curr. Opin. Microbiol. 9, 46\u201354 (2006).","journal-title":"Curr. Opin. Microbiol."},{"key":"484_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mib.2016.08.007","volume":"35","author":"MX Byndloss","year":"2017","unstructured":"Byndloss, M. X., Rivera-Chavez, F., Tsolis, R. M. & Baumler, A. J. How bacterial pathogens use type III and type IV secretion systems to facilitate their transmission. Curr. Opin. Microbiol. 35, 1\u20137 (2017).","journal-title":"Curr. Opin. Microbiol."},{"key":"484_CR7","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.clim.2004.07.014","volume":"114","author":"DG Guiney","year":"2005","unstructured":"Guiney, D. G. & Lesnick, M. Targeting of the actin cytoskeleton during infection by Salmonella strains. Clin. Immunol. 114, 248\u2013255 (2005).","journal-title":"Clin. Immunol."},{"key":"484_CR8","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/S0092-8674(00)81442-7","volume":"93","author":"WD Hardt","year":"1998","unstructured":"Hardt, W. D., Chen, L. M., Schuebel, K. E., Bustelo, X. R. & Galan, J. E. S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Cell 93, 815\u2013826 (1998).","journal-title":"Cell"},{"key":"484_CR9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1462-5822.2011.01703.x","volume":"14","author":"RC Orchard","year":"2012","unstructured":"Orchard, R. C. & Alto, N. M. Mimicking GEFs: a common theme for bacterial pathogens. Cell. Microbiol. 14, 10\u201318 (2012).","journal-title":"Cell. Microbiol."},{"key":"484_CR10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.chom.2012.01.006","volume":"11","author":"D Humphreys","year":"2012","unstructured":"Humphreys, D., Davidson, A., Hume, P. J. & Koronakis, V. Salmonella virulence effector SopE and host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion. Cell Host Microbe 11, 129\u2013139 (2012).","journal-title":"Cell Host Microbe"},{"key":"484_CR11","doi-asserted-by":"publisher","first-page":"4379","DOI":"10.1073\/pnas.0400628101","volume":"101","author":"A Gautreau","year":"2004","unstructured":"Gautreau, A. et al. Purification and architecture of the ubiquitous Wave complex. Proc. Natl Acad. Sci. USA 101, 4379\u20134383 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"484_CR12","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nature00859","volume":"418","author":"S Eden","year":"2002","unstructured":"Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M. & Kirschner, M. W. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 418, 790\u2013793 (2002).","journal-title":"Nature"},{"key":"484_CR13","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nsmb.1587","volume":"16","author":"AM Ismail","year":"2009","unstructured":"Ismail, A. M., Padrick, S. B., Chen, B., Umetani, J. & Rosen, M. K. The WAVE regulatory complex is inhibited. Nat. Struct. Mol. Biol. 16, 561\u2013563 (2009).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"484_CR14","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nature09623","volume":"468","author":"Z Chen","year":"2010","unstructured":"Chen, Z. et al. Structure and control of the actin regulatory WAVE complex. Nature 468, 533\u2013538 (2010).","journal-title":"Nature"},{"key":"484_CR15","doi-asserted-by":"publisher","first-page":"e29795","DOI":"10.7554\/eLife.29795","volume":"6","author":"B Chen","year":"2017","unstructured":"Chen, B. et al. Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites. eLife 6, e29795 (2017).","journal-title":"eLife"},{"key":"484_CR16","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/364639a0","volume":"364","author":"CL Francis","year":"1993","unstructured":"Francis, C. L., Ryan, T. A., Jones, B. D., Smith, S. J. & Falkow, S. Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria. Nature 364, 639\u2013642 (1993).","journal-title":"Nature"},{"key":"484_CR17","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.mib.2008.01.002","volume":"11","author":"O Steele-Mortimer","year":"2008","unstructured":"Steele-Mortimer, O. The Salmonella-containing vacuole: moving with the times. Curr. Opin. Microbiol. 11, 38\u201345 (2008).","journal-title":"Curr. Opin. Microbiol."},{"key":"484_CR18","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/nrmicro2602","volume":"9","author":"H Ham","year":"2011","unstructured":"Ham, H., Sreelatha, A. & Orth, K. Manipulation of host membranes by bacterial effectors. Nat. Rev. Microbiol. 9, 635\u2013646 (2011).","journal-title":"Nat. Rev. Microbiol."},{"key":"484_CR19","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/prca.201100083","volume":"6","author":"S Schleker","year":"2012","unstructured":"Schleker, S. et al. The current Salmonella-host interactome. Proteom. Clin. Appl. 6, 117\u2013133 (2012).","journal-title":"Proteom. Clin. Appl."},{"key":"484_CR20","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nri3877","volume":"15","author":"S Mostowy","year":"2015","unstructured":"Mostowy, S. & Shenoy, A. R. The cytoskeleton in cell-autonomous immunity: structural determinants of host defence. Nat. Rev. Immunol. 15, 559\u2013573 (2015).","journal-title":"Nat. Rev. Immunol."},{"key":"484_CR21","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.it.2014.12.003","volume":"36","author":"J Behnsen","year":"2015","unstructured":"Behnsen, J., Perez-Lopez, A., Nuccio, S. P. & Raffatellu, M. Exploiting host immunity: the Salmonella paradigm. Trends Immunol. 36, 112\u2013120 (2015).","journal-title":"Trends Immunol."},{"key":"484_CR22","doi-asserted-by":"publisher","first-page":"17915","DOI":"10.1073\/pnas.0604054103","volume":"103","author":"MJ Worley","year":"2006","unstructured":"Worley, M. J., Nieman, G. S., Geddes, K. & Heffron, F. Salmonella typhimurium disseminates within its host by manipulating the motility of infected cells. Proc. Natl Acad. Sci. USA 103, 17915\u201317920 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"484_CR23","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1146\/annurev.med.52.1.259","volume":"52","author":"ME Ohl","year":"2001","unstructured":"Ohl, M. E. & Miller, S. I. Salmonella: a model for bacterial pathogenesis. Annu. Rev. Med. 52, 259\u2013274 (2001).","journal-title":"Annu. Rev. Med."},{"key":"484_CR24","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1128\/CMR.00066-12","volume":"26","author":"A Fabrega","year":"2013","unstructured":"Fabrega, A. & Vila, J. Salmonella enterica serovar Typhimurium skills to succeed in the host: virulence and regulation. Clin. Microbiol. Rev. 26, 308\u2013341 (2013).","journal-title":"Clin. Microbiol. Rev."},{"key":"484_CR25","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/44593","volume":"401","author":"A Vazquez-Torres","year":"1999","unstructured":"Vazquez-Torres, A. et al. Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. Nature 401, 804\u2013808 (1999).","journal-title":"Nature"},{"key":"484_CR26","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1089\/fpd.2010.0787","volume":"8","author":"RS Hendriksen","year":"2011","unstructured":"Hendriksen, R. S. et al. Global monitoring of Salmonella serovar distribution from the world health organization global foodborne infections network country data bank: results of quality assured laboratories from 2001 to 2007. Foodborne Pathog. Dis. 8, 887\u2013900 (2011).","journal-title":"Foodborne Pathog. Dis."},{"key":"484_CR27","doi-asserted-by":"publisher","first-page":"W244","DOI":"10.1093\/nar\/gki408","volume":"33","author":"J Soding","year":"2005","unstructured":"Soding, J., Biegert, A. & Lupas, A. N. The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res. 33, W244\u2013W248 (2005).","journal-title":"Nucleic Acids Res."},{"key":"484_CR28","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/375338a0","volume":"375","author":"F Michiels","year":"1995","unstructured":"Michiels, F., Habets, G. G., Stam, J. C., van der Kammen, R. A. & Collard, J. G. A role for Rac in Tiam1-induced membrane ruffling and invasion. Nature 375, 338\u2013340 (1995).","journal-title":"Nature"},{"key":"484_CR29","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/ng.2359","volume":"44","author":"M Krauthammer","year":"2012","unstructured":"Krauthammer, M. et al. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat. Genet. 44, 1006\u20131014 (2012).","journal-title":"Nat. Genet."},{"key":"484_CR30","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1126\/science.1175862","volume":"326","author":"TD Pollard","year":"2009","unstructured":"Pollard, T. D. & Cooper, J. A. Actin, a central player in cell shape and movement. Science 326, 1208\u20131212 (2009).","journal-title":"Science"},{"key":"484_CR31","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1126\/science.6681676","volume":"219","author":"I Spector","year":"1983","unstructured":"Spector, I., Shochet, N. R., Kashman, Y. & Groweiss, A. Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells. Science 219, 493\u2013495 (1983).","journal-title":"Science"},{"key":"484_CR32","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1242\/jcs.114.6.1061","volume":"114","author":"RC May","year":"2001","unstructured":"May, R. C. & Machesky, L. M. Phagocytosis and the actin cytoskeleton. J. Cell Sci. 114, 1061\u20131077 (2001).","journal-title":"J. Cell Sci."},{"key":"484_CR33","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/nrm3861","volume":"15","author":"M Krause","year":"2014","unstructured":"Krause, M. & Gautreau, A. Steering cell migration: lamellipodium dynamics and the regulation of directional persistence. Nat. Rev. Mol. Cell Biol. 15, 577\u2013590 (2014).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"484_CR34","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/1521-4141(200003)30:3<944::AID-IMMU944>3.0.CO;2-1","volume":"30","author":"OL Wijburg","year":"2000","unstructured":"Wijburg, O. L., Simmons, C. P., van Rooijen, N. & Strugnell, R. A. Dual role for macrophages in vivo in pathogenesis and control of murine Salmonella enterica var. Typhimurium infections. Eur. J. Immunol. 30, 944\u2013953 (2000).","journal-title":"Eur. J. Immunol."},{"key":"484_CR35","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1084\/jem.186.4.569","volume":"186","author":"A Richter-Dahlfors","year":"1997","unstructured":"Richter-Dahlfors, A., Buchan, A. M. & Finlay, B. B. Murine salmonellosis studied by confocal microscopy: Salmonella typhimurium resides intracellularly inside macrophages and exerts a cytotoxic effect on phagocytes in vivo. J. Exp. Med. 186, 569\u2013580 (1997).","journal-title":"J. Exp. Med."},{"key":"484_CR36","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1073\/pnas.76.5.2345","volume":"76","author":"DC Lin","year":"1979","unstructured":"Lin, D. C. & Lin, S. Actin polymerization induced by a motility-related high-affinity cytochalasin binding complex from human erythrocyte membrane. Proc. Natl Acad. Sci. USA 76, 2345\u20132349 (1979).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"484_CR37","doi-asserted-by":"publisher","first-page":"ra124","DOI":"10.1126\/scisignal.aah5882","volume":"9","author":"CC Campa","year":"2016","unstructured":"Campa, C. C. et al. Rac signal adaptation controls neutrophil mobilization from the bone marrow. Sci. Signal. 9, ra124 (2016).","journal-title":"Sci. Signal."},{"key":"484_CR38","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1083\/jcb.200503152","volume":"170","author":"R Pankov","year":"2005","unstructured":"Pankov, R. et al. A Rac switch regulates random versus directionally persistent cell migration. J. Cell Biol. 170, 793\u2013802 (2005).","journal-title":"J. Cell Biol."},{"key":"484_CR39","doi-asserted-by":"publisher","first-page":"27149","DOI":"10.1074\/jbc.M302475200","volume":"278","author":"MC Schlumberger","year":"2003","unstructured":"Schlumberger, M. C. et al. Amino acids of the bacterial toxin SopE involved in G nucleotide exchange on Cdc42. J. Biol. Chem. 278, 27149\u201327159 (2003).","journal-title":"J. Biol. Chem."},{"key":"484_CR40","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.molcel.2016.04.015","volume":"62","author":"E Fiskin","year":"2016","unstructured":"Fiskin, E., Bionda, T., Dikic, I. & Behrends, C. Global analysis of host and bacterial ubiquitinome in response to Salmonella Typhimurium infection. Mol. Cell 62, 967\u2013981 (2016).","journal-title":"Mol. Cell"},{"key":"484_CR41","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1128\/iai.62.2.543-553.1994","volume":"62","author":"C de Chastellier","year":"1994","unstructured":"de Chastellier, C. & Berche, P. Fate of Listeria monocytogenes in murine macrophages: evidence for simultaneous killing and survival of intracellular bacteria. Infect. Immun. 62, 543\u2013553 (1994).","journal-title":"Infect. Immun."},{"key":"484_CR42","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1016\/j.febslet.2014.05.051","volume":"588","author":"P Cossart","year":"2014","unstructured":"Cossart, P. & Lebreton, A. A trip in the \u201cNew Microbiology\u201d with the bacterial pathogen Listeria monocytogenes. FEBS Lett. 588, 2437\u20132445 (2014).","journal-title":"FEBS Lett."},{"key":"484_CR43","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.celrep.2017.09.034","volume":"21","author":"MVS Rajaram","year":"2017","unstructured":"Rajaram, M. V. S. et al. M. tuberculosis-initiated human mannose receptor signaling regulates macrophage recognition and vesicle trafficking by FcR\u03b3-Chain, Grb2, and SHP-1. Cell Rep. 21, 126\u2013140 (2017).","journal-title":"Cell Rep."},{"key":"484_CR44","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1111\/cmi.12324","volume":"16","author":"K Ireton","year":"2014","unstructured":"Ireton, K., Rigano, L. A. & Dowd, G. C. Role of host GTPases in infection by Listeria monocytogenes. Cell Microbiol. 16, 1311\u20131320 (2014).","journal-title":"Cell Microbiol."},{"issue":"17","key":"484_CR45","doi-asserted-by":"publisher","first-page":"E4051","DOI":"10.1073\/pnas.1801340115","volume":"115","author":"Wanjing Shang","year":"2018","unstructured":"Shang, W. et al. Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activation. Proc. Natl Acad. Sci. USA 115, E4051\u2013E4060 (2018).","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"484_CR46","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1038\/s41556-018-0198-9","volume":"20","author":"L Fort","year":"2018","unstructured":"Fort, L. et al. Fam49\/CYRI interacts with Rac1 and locally suppresses protrusions. Nat. Cell Biol. 20, 1159\u20131171 (2018).","journal-title":"Nat. Cell Biol."},{"key":"484_CR47","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.3389\/fmicb.2017.02284","volume":"8","author":"CJ Queval","year":"2017","unstructured":"Queval, C. J., Brosch, R. & Simeone, R. The macrophage: a disputed fortress in the battle against Mycobacterium tuberculosis. Front. Microbiol. 8, 2284 (2017).","journal-title":"Front. Microbiol."},{"key":"484_CR48","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1038\/s41588-018-0254-1","volume":"50","author":"MS Haney","year":"2018","unstructured":"Haney, M. S. et al. Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens. Nat. Genet. 50, 1716\u20131727 (2018).","journal-title":"Nat. Genet."},{"key":"484_CR49","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1128\/IAI.67.7.3512-3517.1999","volume":"67","author":"DA Drevets","year":"1999","unstructured":"Drevets, D. A. Dissemination of Listeria monocytogenes by infected phagocytes. Infect. Immun. 67, 3512\u20133517 (1999).","journal-title":"Infect. Immun."},{"key":"484_CR50","doi-asserted-by":"crossref","unstructured":"Maculins, T., Fiskin, E., Bhogaraju, S. & Dikic, I. Bacteria-host relationship: ubiquitin ligases as weapons of invasion. Cell Res. 26, 499\u2013510 (2016).","DOI":"10.1038\/cr.2016.30"},{"key":"484_CR51","doi-asserted-by":"publisher","first-page":"2949","DOI":"10.1084\/jem.20062606","volume":"204","author":"MF Roy","year":"2007","unstructured":"Roy, M. F. et al. Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice. J. Exp. Med. 204, 2949\u20132961 (2007).","journal-title":"J. Exp. Med."},{"key":"484_CR52","doi-asserted-by":"publisher","first-page":"2839","DOI":"10.1128\/IAI.71.5.2839-2858.2003","volume":"71","author":"M Barthel","year":"2003","unstructured":"Barthel, M. et al. Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host. Infect. Immun. 71, 2839\u20132858 (2003).","journal-title":"Infect. Immun."},{"key":"484_CR53","doi-asserted-by":"publisher","first-page":"259","DOI":"10.4049\/jimmunol.1301370","volume":"192","author":"MM Eva","year":"2014","unstructured":"Eva, M. M. et al. Altered IFN-\u03b3-mediated immunity and transcriptional expression patterns in N-ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease. J. Immunol. 192, 259\u2013270 (2014).","journal-title":"J. Immunol."},{"key":"484_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10664","volume":"7","author":"H Marei","year":"2016","unstructured":"Marei, H. et al. Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration. Nat. Commun. 7, 10664 (2016).","journal-title":"Nat. Commun."},{"key":"484_CR55","doi-asserted-by":"publisher","first-page":"13198","DOI":"10.1074\/jbc.274.19.13198","volume":"274","author":"V Benard","year":"1999","unstructured":"Benard, V., Bohl, B. P. & Bokoch, G. M. Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J. Biol. Chem. 274, 13198\u201313204 (1999).","journal-title":"J. Biol. Chem."},{"key":"484_CR56","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1080\/15384101.2016.1183852","volume":"15","author":"H Marei","year":"2016","unstructured":"Marei, H., Carpy, A., Macek, B. & Malliri, A. Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors. Cell Cycle 15, 1961\u20131974 (2016).","journal-title":"Cell Cycle"},{"key":"484_CR57","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0076-6879(06)21016-4","volume":"421","author":"JE Karlinsey","year":"2007","unstructured":"Karlinsey, J. E. \u03bb-Red genetic engineering in Salmonella enterica serovar Typhimurium. Methods Enzym. 421, 199\u2013209 (2007).","journal-title":"Methods Enzym."},{"key":"484_CR58","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature10163","volume":"474","author":"WC Skarnes","year":"2011","unstructured":"Skarnes, W. C. et al. A conditional knockout resource for the genome-wide study of mouse gene function. Nature 474, 337\u2013342 (2011).","journal-title":"Nature"},{"key":"484_CR59","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1006\/geno.2001.6528","volume":"74","author":"A Fortin","year":"2001","unstructured":"Fortin, A. et al. Recombinant congenic strains derived from A\/J and C57BL\/6J: a tool for genetic dissection of complex traits. Genomics 74, 21\u201335 (2001).","journal-title":"Genomics"},{"key":"484_CR60","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/nm.2601","volume":"18","author":"AJ Cunnington","year":"2011","unstructured":"Cunnington, A. J., de Souza, J. B., Walther, M. & Riley, E. M. Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization. Nat. Med. 18, 120\u2013127 (2011).","journal-title":"Nat. Med."},{"key":"484_CR61","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/978-1-61779-207-6_11","volume":"769","author":"M Sixt","year":"2011","unstructured":"Sixt, M. & Lammermann, T. In vitro analysis of chemotactic leukocyte migration in 3D environments. Methods Mol. Biol. 769, 149\u2013165 (2011).","journal-title":"Methods Mol. Biol."}],"container-title":["Nature Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41564-019-0484-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-019-0484-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-019-0484-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T22:45:47Z","timestamp":1671230747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41564-019-0484-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,8]]},"references-count":61,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["484"],"URL":"https:\/\/doi.org\/10.1038\/s41564-019-0484-8","relation":{},"ISSN":["2058-5276"],"issn-type":[{"value":"2058-5276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,8]]},"assertion":[{"value":"26 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}