{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:51:09Z","timestamp":1791723069868,"version":"4.3.4"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T00:00:00Z","timestamp":1575244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Microbiol"],"DOI":"10.1038\/s41564-019-0614-3","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T17:04:55Z","timestamp":1575306295000},"page":"192-205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Functional screenings reveal different requirements for host microRNAs in Salmonella and Shigella infection"],"prefix":"10.1038","volume":"5","author":[{"given":"Carmen","family":"Aguilar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Rita","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Rodrigues Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8856-0819","authenticated-orcid":false,"given":"Claire","family":"Maudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ushasree","family":"Sunkavalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-5119","authenticated-orcid":false,"given":"Ricardo Jorge","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malvika","family":"Sharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clivia","family":"Lisowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Zald\u00edvar-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2927-7225","authenticated-orcid":false,"given":"Mauro","family":"Giacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-4824","authenticated-orcid":false,"given":"Miguel","family":"Mano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7355-0674","authenticated-orcid":false,"given":"Ana","family":"Eulalio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,2]]},"reference":[{"key":"614_CR1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","volume":"173","author":"DP Bartel","year":"2018","unstructured":"Bartel, D. P. Metazoan microRNAs. Cell 173, 20\u201351 (2018).","journal-title":"Cell"},{"key":"614_CR2","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nrg3965","volume":"16","author":"S Jonas","year":"2015","unstructured":"Jonas, S. & Izaurralde, E. Towards a molecular understanding of microRNA-mediated gene silencing. Nat. Rev. Genet. 16, 421\u2013433 (2015).","journal-title":"Nat. Rev. Genet."},{"key":"614_CR3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1101\/gr.082701.108","volume":"19","author":"RC Friedman","year":"2009","unstructured":"Friedman, R. C., Farh, K. K., Burge, C. B. & Bartel, D. P. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19, 92\u2013105 (2009).","journal-title":"Genome Res."},{"key":"614_CR4","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.tim.2018.10.011","volume":"27","author":"C Aguilar","year":"2019","unstructured":"Aguilar, C., Mano, M. & Eulalio, A. MicroRNAs at the host\u2013bacteria interface: host defense or bacterial offense. Trends Microbiol. 27, 206\u2013218 (2019).","journal-title":"Trends Microbiol."},{"key":"614_CR5","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.semcdb.2016.06.016","volume":"65","author":"M Duval","year":"2017","unstructured":"Duval, M., Cossart, P. & Lebreton, A. Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk. Semin. Cell. Dev. Biol. 65, 11\u201319 (2017).","journal-title":"Semin. Cell. Dev. Biol."},{"key":"614_CR6","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1177\/1087057115578837","volume":"20","author":"A Eulalio","year":"2015","unstructured":"Eulalio, A. & Mano, M. MicroRNA screening and the quest for biologically relevant targets. J. Biomol. Screen. 20, 1003\u20131017 (2015).","journal-title":"J. Biomol. Screen."},{"key":"614_CR7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3389\/fphys.2013.00223","volume":"4","author":"D Lemons","year":"2013","unstructured":"Lemons, D., Maurya, M. R., Subramaniam, S. & Mercola, M. Developing microRNA screening as a functional genomics tool for disease research. Front. Physiol. 4, 223 (2013).","journal-title":"Front. Physiol."},{"key":"614_CR8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ymeth.2018.09.011","volume":"152","author":"I Rodrigues Lopes","year":"2019","unstructured":"Rodrigues Lopes, I., Silva, R. J., Caramelo, I., Eulalio, A. & Mano, M. Shedding light on microRNA function via microscopy-based screening. Methods 152, 55\u201364 (2019).","journal-title":"Methods"},{"key":"614_CR9","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/ncb1681","volume":"10","author":"Q Huang","year":"2008","unstructured":"Huang, Q. et al. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat. Cell Biol. 10, 202\u2013210 (2008).","journal-title":"Nat. Cell Biol."},{"key":"614_CR10","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature11739","volume":"492","author":"A Eulalio","year":"2012","unstructured":"Eulalio, A. et al. Functional screening identifies miRNAs inducing cardiac regeneration. Nature 492, 376\u2013381 (2012).","journal-title":"Nature"},{"key":"614_CR11","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1038\/nsmb.2665","volume":"20","author":"RL Judson","year":"2013","unstructured":"Judson, R. L., Greve, T. S., Parchem, R. J. & Blelloch, R. MicroRNA-based discovery of barriers to dedifferentiation of fibroblasts to pluripotent stem cells. Nat. Struct. Mol. Biol. 20, 1227\u20131235 (2013).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"614_CR12","doi-asserted-by":"publisher","first-page":"13830","DOI":"10.1073\/pnas.1008861107","volume":"107","author":"D Santhakumar","year":"2010","unstructured":"Santhakumar, D. et al. Combined agonist\u2013antagonist genome-wide functional screening identifies broadly active antiviral microRNAs. Proc. Natl Acad. Sci. USA 107, 13830\u201313835 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"614_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5718","volume":"5","author":"C Maudet","year":"2014","unstructured":"Maudet, C. et al. Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection. Nat. Commun. 5, 4718 (2014).","journal-title":"Nat. Commun."},{"key":"614_CR14","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/S1473-3099(17)30276-1","volume":"17","author":"GBDDD Collaborators","year":"2017","unstructured":"Collaborators, G. B. D. D. D. Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. Infect. Dis. 17, 909\u2013948 (2017).","journal-title":"Lancet. Infect. Dis."},{"key":"614_CR15","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1097\/QCO.0000000000000398","volume":"30","author":"AH Haselbeck","year":"2017","unstructured":"Haselbeck, A. H. et al. Current perspectives on invasive nontyphoidal Salmonella disease. Curr. Opin. Infect. Dis. 30, 498\u2013503 (2017).","journal-title":"Curr. Opin. Infect. Dis."},{"key":"614_CR16","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/S0140-6736(17)33296-8","volume":"391","author":"KL Kotloff","year":"2018","unstructured":"Kotloff, K. L., Riddle, M. S., Platts-Mills, J. A., Pavlinac, P. & Zaidi, A. K. M. Shigellosis. Lancet 391, 801\u2013812 (2018).","journal-title":"Lancet"},{"key":"614_CR17","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.mib.2008.01.002","volume":"11","author":"O Steele-Mortimer","year":"2008","unstructured":"Steele-Mortimer, O. The Salmonella-containing vacuole: moving with the times. Curr. Opin. Microbiol. 11, 38\u201345 (2008).","journal-title":"Curr. Opin. Microbiol."},{"key":"614_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3389\/fcimb.2016.00035","volume":"6","author":"N Mellouk","year":"2016","unstructured":"Mellouk, N. & Enninga, J. Cytosolic access of intracellular bacterial pathogens: the Shigella paradigm. Front. Cell. Infect. Microbiol. 6, 35 (2016).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"614_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3389\/fcimb.2016.00029","volume":"6","author":"H Agaisse","year":"2016","unstructured":"Agaisse, H. Molecular and cellular mechanisms of Shigella flexneri dissemination. Front. Cell. Infect. Microbiol. 6, 29 (2016).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"614_CR20","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.tcb.2008.03.001","volume":"18","author":"A Lambrechts","year":"2008","unstructured":"Lambrechts, A., Gevaert, K., Cossart, P., Vandekerckhove, J. & Van Troys, M. Listeria comet tails: the actin-based motility machinery at work. Trends Cell Biol. 18, 220\u2013227 (2008).","journal-title":"Trends Cell Biol."},{"key":"614_CR21","doi-asserted-by":"publisher","first-page":"05005","DOI":"10.7554\/eLife.05005","volume":"4","author":"V Agarwal","year":"2015","unstructured":"Agarwal, V., Bell, G. W., Nam, J. W. & Bartel, D. P. Predicting effective microRNA target sites in mammalian mRNAs. eLife 4, 05005 (2015).","journal-title":"eLife"},{"key":"614_CR22","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1083\/jcb.146.6.1319","volume":"146","author":"C Egile","year":"1999","unstructured":"Egile, C. et al. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2\/3 complex and bacterial actin-based motility. J. Cell Biol. 146, 1319\u20131332 (1999).","journal-title":"J. Cell Biol."},{"key":"614_CR23","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1046\/j.1462-5822.2002.00185.x","volume":"4","author":"T Suzuki","year":"2002","unstructured":"Suzuki, T. et al. Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading. Cell. Microbiol. 4, 223\u2013233 (2002).","journal-title":"Cell. Microbiol."},{"key":"614_CR24","doi-asserted-by":"publisher","first-page":"11390","DOI":"10.1021\/bi010486b","volume":"40","author":"R Boujemaa-Paterski","year":"2001","unstructured":"Boujemaa-Paterski, R. et al. Listeria protein ActA mimics WASp family proteins: it activates filament barbed end branching by Arp2\/3 complex. Biochemistry 40, 11390\u201311404 (2001).","journal-title":"Biochemistry"},{"key":"614_CR25","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1242\/jcs.02285","volume":"118","author":"H Bierne","year":"2005","unstructured":"Bierne, H. et al. WASP-related proteins, Abi1 and Ena\/VASP are required for Listeria invasion induced by the Met receptor. J. Cell Sci. 118, 1537\u20131547 (2005).","journal-title":"J. Cell Sci."},{"key":"614_CR26","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1128\/IAI.00077-09","volume":"77","author":"M Lara-Tejero","year":"2009","unstructured":"Lara-Tejero, M. & Galan, J. E. Salmonella enterica serovar Typhimurium pathogenicity island 1-encoded type III secretion system translocases mediate intimate attachment to nonphagocytic cells. Infect. Immun. 77, 2635\u20132642 (2009).","journal-title":"Infect. Immun."},{"key":"614_CR27","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1128\/IAI.00581-10","volume":"79","author":"B Misselwitz","year":"2011","unstructured":"Misselwitz, B. et al. Salmonella enterica serovar Typhimurium binds to HeLa cells via Fim-mediated reversible adhesion and irreversible type three secretion system 1-mediated docking. Infect. Immun. 79, 330\u2013341 (2011).","journal-title":"Infect. Immun."},{"key":"614_CR28","doi-asserted-by":"publisher","first-page":"12548","DOI":"10.1073\/pnas.0503407102","volume":"102","author":"MC Schlumberger","year":"2005","unstructured":"Schlumberger, M. C. et al. Real-time imaging of type III secretion: Salmonella SipA injection into host cells. Proc. Natl Acad. Sci. USA 102, 12548\u201312553 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"614_CR29","doi-asserted-by":"publisher","first-page":"5899","DOI":"10.1128\/jb.175.18.5899-5906.1993","volume":"175","author":"R Menard","year":"1993","unstructured":"Menard, R., Sansonetti, P. J. & Parsot, C. Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells. J. Bacteriol. 175, 5899\u20135906 (1993).","journal-title":"J. Bacteriol."},{"key":"614_CR30","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/bs.ircmb.2015.02.001","volume":"317","author":"GE Woodard","year":"2015","unstructured":"Woodard, G. E., Jardin, I., Berna-Erro, A., Salido, G. M. & Rosado, J. A. Regulators of G-protein-signaling proteins: negative modulators of G-protein-coupled receptor signaling. Int. Rev. Cell Mol. Biol. 317, 97\u2013183 (2015).","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"614_CR31","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.cellsig.2010.03.016","volume":"22","author":"N Sethakorn","year":"2010","unstructured":"Sethakorn, N., Yau, D. M. & Dulin, N. O. Non-canonical functions of RGS proteins. Cell. Signal. 22, 1274\u20131281 (2010).","journal-title":"Cell. Signal."},{"key":"614_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mib.2018.10.003","volume":"47","author":"A Tuli","year":"2018","unstructured":"Tuli, A. & Sharma, M. How to do business with lysosomes: Salmonella leads the way. Curr. Opin. Microbiol. 47, 1\u20137 (2018).","journal-title":"Curr. Opin. Microbiol."},{"key":"614_CR33","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1083\/jcb.129.1.81","volume":"129","author":"F Garcia-del Portillo","year":"1995","unstructured":"Garcia-del Portillo, F. & Finlay, B. B. Targeting of Salmonella typhimurium to vesicles containing lysosomal membrane glycoproteins bypasses compartments with mannose 6-phosphate receptors. J. Cell Biol. 129, 81\u201397 (1995).","journal-title":"J. Cell Biol."},{"key":"614_CR34","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1128\/iai.65.4.1475-1485.1997","volume":"65","author":"M Rathman","year":"1997","unstructured":"Rathman, M., Barker, L. P. & Falkow, S. The unique trafficking pattern of Salmonella typhimurium-containing phagosomes in murine macrophages is independent of the mechanism of bacterial entry. Infect. Immun. 65, 1475\u20131485 (1997).","journal-title":"Infect. Immun."},{"key":"614_CR35","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1111\/cmi.12475","volume":"17","author":"JC Santos","year":"2015","unstructured":"Santos, J. C. et al. The COPII complex and lysosomal VAMP7 determine intracellular Salmonella localization and growth. Cell. Microbiol. 17, 1699\u20131720 (2015).","journal-title":"Cell. Microbiol."},{"key":"614_CR36","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1021\/cb600431a","volume":"1","author":"HC Hang","year":"2006","unstructured":"Hang, H. C. et al. Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells. ACS Chem. Biol. 1, 713\u2013723 (2006).","journal-title":"ACS Chem. Biol."},{"key":"614_CR37","doi-asserted-by":"publisher","first-page":"4394","DOI":"10.1093\/emboj\/18.16.4394","volume":"18","author":"S Meresse","year":"1999","unstructured":"Meresse, S., Steele-Mortimer, O., Finlay, B. B. & Gorvel, J. P. The rab7 GTPase controls the maturation of Salmonella typhimurium-containing vacuoles in HeLa cells. EMBO J. 18, 4394\u20134403 (1999).","journal-title":"EMBO J."},{"key":"614_CR38","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1083\/jcb.130.4.781","volume":"130","author":"WJ Brown","year":"1995","unstructured":"Brown, W. J., DeWald, D. B., Emr, S. D., Plutner, H. & Balch, W. E. Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells. J. Cell Biol. 130, 781\u2013796 (1995).","journal-title":"J. Cell Biol."},{"key":"614_CR39","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1083\/jcb.130.4.797","volume":"130","author":"HW Davidson","year":"1995","unstructured":"Davidson, H. W. Wortmannin causes mistargeting of procathepsin D. Evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes. J. Cell Biol. 130, 797\u2013805 (1995).","journal-title":"J. Cell Biol."},{"key":"614_CR40","doi-asserted-by":"publisher","first-page":"24170","DOI":"10.1074\/jbc.272.39.24170","volume":"272","author":"P Gaffet","year":"1997","unstructured":"Gaffet, P., Jones, A. T. & Clague, M. J. Inhibition of calcium-independent mannose 6-phosphate receptor incorporation into trans-Golgi network-derived clathrin-coated vesicles by wortmannin. J. Biol. Chem. 272, 24170\u201324175 (1997).","journal-title":"J. Biol. Chem."},{"key":"614_CR41","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.bbrc.2008.09.121","volume":"377","author":"K Ikeda","year":"2008","unstructured":"Ikeda, K. et al. Drug-induced phospholipidosis is caused by blockade of mannose 6-phosphate receptor-mediated targeting of lysosomal enzymes. Biochem. Biophys. Res. Commun. 377, 268\u2013274 (2008).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"614_CR42","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1242\/jcs.109.4.749","volume":"109","author":"BJ Reaves","year":"1996","unstructured":"Reaves, B. J., Bright, N. A., Mullock, B. M. & Luzio, J. P. The effect of wortmannin on the localisation of lysosomal type I integral membrane glycoproteins suggests a role for phosphoinositide 3-kinase activity in regulating membrane traffic late in the endocytic pathway. J. Cell Sci. 109, 749\u2013762 (1996).","journal-title":"J. Cell Sci."},{"key":"614_CR43","doi-asserted-by":"publisher","first-page":"3264","DOI":"10.1128\/IAI.70.6.3264-3270.2002","volume":"70","author":"JH Brumell","year":"2002","unstructured":"Brumell, J. H., Tang, P., Zaharik, M. L. & Finlay, B. B. Disruption of the Salmonella-containing vacuole leads to increased replication of Salmonella enterica serovar typhimurium in the cytosol of epithelial cells. Infect. Immun. 70, 3264\u20133270 (2002).","journal-title":"Infect. Immun."},{"key":"614_CR44","doi-asserted-by":"publisher","DOI":"10.1051\/vetres\/2009072","volume":"41","author":"M Collado-Romero","year":"2010","unstructured":"Collado-Romero, M., Arce, C., Ramirez-Boo, M., Carvajal, A. & Garrido, J. J. Quantitative analysis of the immune response upon Salmonella typhimurium infection along the porcine intestinal gut. Vet. Res. 41, 23 (2010).","journal-title":"Vet. Res."},{"key":"614_CR45","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.molcel.2016.09.027","volume":"64","author":"R Denzler","year":"2016","unstructured":"Denzler, R. et al. Impact of microRNA levels, target-site complementarity, and cooperativity on competing endogenous RNA-regulated gene expression. Mol. Cell 64, 565\u2013579 (2016).","journal-title":"Mol. Cell"},{"key":"614_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-8-r166","volume":"8","author":"LS Hon","year":"2007","unstructured":"Hon, L. S. & Zhang, Z. The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression. Genome Biol. 8, R166 (2007).","journal-title":"Genome Biol."},{"key":"614_CR47","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nrm2867","volume":"11","author":"KG Campellone","year":"2010","unstructured":"Campellone, K. G. & Welch, M. D. A nucleator arms race: cellular control of actin assembly. Nat. Rev. Mol. Cell Biol. 11, 237\u2013251 (2010).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"614_CR48","doi-asserted-by":"publisher","first-page":"e1006327","DOI":"10.1371\/journal.ppat.1006327","volume":"13","author":"U Sunkavalli","year":"2017","unstructured":"Sunkavalli, U. et al. Analysis of host microRNA function uncovers a role for miR-29b-2-5p in Shigella capture by filopodia. PLoS Pathog. 13, e1006327 (2017).","journal-title":"PLoS Pathog."},{"key":"614_CR49","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3389\/fcimb.2017.00348","volume":"7","author":"PJ Hume","year":"2017","unstructured":"Hume, P. J., Singh, V., Davidson, A. C. & Koronakis, V. Swiss Army pathogen: the Salmonella entry toolkit. Front. Cell. Infect. Microbiol. 7, 348 (2017).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"614_CR50","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/164_2016_42","volume":"235","author":"GT Van Nhieu","year":"2017","unstructured":"Van Nhieu, G. T. & Romero, S. Common themes in cytoskeletal remodeling by intracellular bacterial effectors. Handb. Exp. Pharmacol. 235, 207\u2013235 (2017).","journal-title":"Handb. Exp. Pharmacol."},{"key":"614_CR51","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.1091\/mbc.11.9.3155","volume":"11","author":"BM Sullivan","year":"2000","unstructured":"Sullivan, B. M. et al. RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. Mol. Biol. Cell 11, 3155\u20133168 (2000).","journal-title":"Mol. Biol. Cell"},{"key":"614_CR52","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1126\/science.1227037","volume":"338","author":"K McGourty","year":"2012","unstructured":"McGourty, K. et al. Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function. Science 338, 963\u2013967 (2012).","journal-title":"Science"},{"key":"614_CR53","doi-asserted-by":"publisher","first-page":"e98529","DOI":"10.15252\/embj.201798529","volume":"37","author":"C Tawk","year":"2018","unstructured":"Tawk, C. et al. Stress-induced host membrane remodeling protects from infection by non-motile bacterial pathogens. EMBO J. 37, e98529 (2018).","journal-title":"EMBO J."},{"key":"614_CR54","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1365-2958.2009.06857.x","volume":"74","author":"K Papenfort","year":"2009","unstructured":"Papenfort, K. et al. Specific and pleiotropic patterns of mRNA regulation by ArcZ, a conserved, Hfq-dependent small RNA. Mol. Microbiol. 74, 139\u2013158 (2009).","journal-title":"Mol. Microbiol."},{"key":"614_CR55","doi-asserted-by":"publisher","first-page":"e17296","DOI":"10.1371\/journal.pone.0017296","volume":"6","author":"A Eulalio","year":"2011","unstructured":"Eulalio, A., Frohlich, K. S., Mano, M., Giacca, M. & Vogel, J. A candidate approach implicates the secreted Salmonella effector protein SpvB in P-body disassembly. PLoS ONE 6, e17296 (2011).","journal-title":"PLoS ONE"},{"key":"614_CR56","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/j.1863-2378.2007.01065.x","volume":"54","author":"C Garcia-Feliz","year":"2007","unstructured":"Garcia-Feliz, C. et al. Salmonella enterica infections in Spanish swine fattening units. Zoonoses Public Health 54, 294\u2013300 (2007).","journal-title":"Zoonoses Public Health"},{"key":"614_CR57","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/ncb1001-927","volume":"3","author":"NK Hussain","year":"2001","unstructured":"Hussain, N. K. et al. Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP. Nat. Cell Biol. 3, 927\u2013932 (2001).","journal-title":"Nat. Cell Biol."},{"key":"614_CR58","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1126\/science.1157535","volume":"320","author":"Y Sancak","year":"2008","unstructured":"Sancak, Y. et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320, 1496\u20131501 (2008).","journal-title":"Science"},{"key":"614_CR59","doi-asserted-by":"publisher","first-page":"e2005970","DOI":"10.1371\/journal.pbio.2005970","volume":"16","author":"C McQuin","year":"2018","unstructured":"McQuin, C. et al. CellProfiler 3.0: Next-generation image processing for biology. PLoS Biol. 16, e2005970 (2018).","journal-title":"PLoS Biol."},{"key":"614_CR60","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fcimb.2015.00064","volume":"5","author":"M Collado-Romero","year":"2015","unstructured":"Collado-Romero, M. et al. Quantitative proteomics and bioinformatic analysis provide new insight into the dynamic response of porcine intestine to Salmonella Typhimurium. Front. Cell. Infect. Microbiol. 5, 64 (2015).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"614_CR61","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1093\/bioinformatics\/btu533","volume":"30","author":"KU Forstner","year":"2014","unstructured":"Forstner, K. U., Vogel, J. & Sharma, C. M. READemption-a tool for the computational analysis of deep-sequencing-based transcriptome data. Bioinformatics 30, 3421\u20133423 (2014).","journal-title":"Bioinformatics"},{"key":"614_CR62","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1093\/bioinformatics\/btu146","volume":"30","author":"C Otto","year":"2014","unstructured":"Otto, C., Stadler, P. F. & Hoffmann, S. Lacking alignments? The next-generation sequencing mapper segemehl revisited. Bioinformatics 30, 1837\u20131843 (2014).","journal-title":"Bioinformatics"},{"key":"614_CR63","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-10-r106","volume":"11","author":"S Anders","year":"2010","unstructured":"Anders, S. & Huber, W. Differential expression analysis for sequence count data. Genome Biol. 11, R106 (2010).","journal-title":"Genome Biol."},{"key":"614_CR64","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/bioinformatics\/18.1.207","volume":"18","author":"A Sturn","year":"2002","unstructured":"Sturn, A., Quackenbush, J. & Trajanoski, Z. Genesis: cluster analysis of microarray data. Bioinformatics 18, 207\u2013208 (2002).","journal-title":"Bioinformatics"}],"container-title":["Nature Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41564-019-0614-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-019-0614-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-019-0614-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T04:07:11Z","timestamp":1671250031000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41564-019-0614-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,2]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"alternative-id":["614"],"URL":"https:\/\/doi.org\/10.1038\/s41564-019-0614-3","relation":{},"ISSN":["2058-5276"],"issn-type":[{"value":"2058-5276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,2]]},"assertion":[{"value":"26 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}