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Malnutrition is a predisposing factor, but the underlying mechanisms are unknown. Here we show that vitamin A deficiency, one of the most prevalent micronutrient deficits afflicting African children, increases susceptibility to disseminated non-typhoidal <jats:italic>Salmonella<\/jats:italic> disease in mice and impairs terminal neutrophil maturation. Immature neutrophils had reduced expression of <jats:italic>Slc11a1<\/jats:italic>, a gene that encodes a metal ion transporter generally thought to restrict pathogen growth in macrophages. Adoptive transfer of SLC11A1-proficient neutrophils, but not SLC11A1-deficient neutrophils, reduced systemic <jats:italic>Salmonella<\/jats:italic> burden in <jats:italic>Slc11a1<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> mice or mice with vitamin A deficiency. Loss of terminal granulopoiesis regulator CCAAT\/enhancer-binding protein \u03f5 (C\/EBP\u03f5) also decreased neutrophil-mediated control of <jats:italic>Salmonella<\/jats:italic>, but not that mediated by peritoneal macrophages. Susceptibility to infection increased in <jats:italic>Cebpe<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup><jats:italic>Slc11a1<\/jats:italic><jats:sup>+\/+<\/jats:sup> mice compared with wild-type controls, in an <jats:italic>Slc11a1<\/jats:italic>-expression-dependent manner. These data suggest that SLC11A1 deficiency impairs <jats:italic>Salmonella<\/jats:italic> control in part by blunting neutrophil-mediated defence.<\/jats:p>","DOI":"10.1038\/s41564-024-01613-0","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T11:04:17Z","timestamp":1708340657000},"page":"727-736","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Vitamin A deficiency impairs neutrophil-mediated control of Salmonella via SLC11A1 in mice"],"prefix":"10.1038","volume":"9","author":[{"given":"Kristen L.","family":"Lokken-Toyli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir E.","family":"Diaz-Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizbeth","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1602-910X","authenticated-orcid":false,"given":"Annica R.","family":"Stull-Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber E. 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