{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:43:27Z","timestamp":1789508607432,"version":"build-2803163510"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000060","name":"U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI15067"],"award-info":[{"award-number":["R01AI15067"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI135964"],"award-info":[{"award-number":["U19AI135964"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI135964"],"award-info":[{"award-number":["U19AI135964"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI163912"],"award-info":[{"award-number":["R21AI163912"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"United States Department of Defense | United States Army | Army Medical Command | Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["MS200290"],"award-info":[{"award-number":["MS200290"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Microbiol"],"DOI":"10.1038\/s41564-024-01786-8","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T19:05:52Z","timestamp":1724439952000},"page":"2383-2394","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1928-5950","authenticated-orcid":false,"given":"Jacob","family":"Class","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4041-6775","authenticated-orcid":false,"given":"Lacy M.","family":"Simons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5462-9483","authenticated-orcid":false,"given":"Ramon","family":"Lorenzo-Redondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6177-0397","authenticated-orcid":false,"given":"Jazmin Galv\u00e1n","family":"Achi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1698-8087","authenticated-orcid":false,"given":"Tanushree","family":"Dangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9986-4906","authenticated-orcid":false,"given":"Pablo","family":"Penaloza-MacMaster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7131-3691","authenticated-orcid":false,"given":"Egon A.","family":"Ozer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6388-753X","authenticated-orcid":false,"given":"Sarah E.","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-4280","authenticated-orcid":false,"given":"Judd F.","family":"Hultquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-118X","authenticated-orcid":false,"given":"Justin M.","family":"Richner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"1786_CR1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s12929-022-00853-8","volume":"29","author":"W-Y Chi","year":"2022","unstructured":"Chi, W.-Y. et al. COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection. J. Biomed. Sci. 29, 82 (2022).","journal-title":"J. Biomed. Sci."},{"key":"1786_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","volume":"19","author":"B Hu","year":"2021","unstructured":"Hu, B., Guo, H., Zhou, P. & Shi, Z.-L. Characteristics of SARS-CoV-2 and COVID-19. Nat. Rev. Microbiol. 19, 141\u2013154 (2021).","journal-title":"Nat. Rev. Microbiol."},{"key":"1786_CR3","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/s41586-022-05542-y","volume":"612","author":"SR Stein","year":"2022","unstructured":"Stein, S. R. et al. SARS-CoV-2 infection and persistence in the human body and brain at autopsy. Nature 612, 758\u2013763 (2022).","journal-title":"Nature"},{"key":"1786_CR4","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3390\/v14030515","volume":"14","author":"C Hartard","year":"2022","unstructured":"Hartard, C. et al. Multiorgan and vascular tropism of SARS-CoV-2. Viruses 14, 515 (2022).","journal-title":"Viruses"},{"key":"1786_CR5","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/s41591-020-0968-3","volume":"26","author":"A Gupta","year":"2020","unstructured":"Gupta, A. et al. Extrapulmonary manifestations of COVID-19. Nat. Med. 26, 1017\u20131032 (2020).","journal-title":"Nat. Med."},{"key":"1786_CR6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","volume":"23","author":"CB Jackson","year":"2022","unstructured":"Jackson, C. B., Farzan, M., Chen, B. & Choe, H. Mechanisms of SARS-CoV-2 entry into cells. Nat. Rev. Mol. Cell Biol. 23, 3\u201320 (2022).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"1786_CR7","first-page":"e00128","volume":"96","author":"R Essalmani","year":"2022","unstructured":"Essalmani, R. et al. Distinctive roles of furin and TMPRSS2 in SARS-CoV-2 infectivity. J. Virol. 96, e00128\u201322 (2022).","journal-title":"J. Virol."},{"key":"1786_CR8","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.tibs.2021.06.001","volume":"46","author":"R Peng","year":"2021","unstructured":"Peng, R., Wu, L.-A., Wang, Q., Qi, J. & Gao, G. F. Cell entry by SARS-CoV-2. Trends Biochem. Sci 46, 848\u2013860 (2021).","journal-title":"Trends Biochem. Sci"},{"key":"1786_CR9","doi-asserted-by":"publisher","first-page":"101212","DOI":"10.1016\/j.isci.2020.101212","volume":"23","author":"JA Jaimes","year":"2020","unstructured":"Jaimes, J. A., Millet, J. K. & Whittaker, G. R. Proteolytic cleavage of the SARS-CoV-2 spike protein and the role of the novel S1\/S2 site. iScience 23, 101212 (2020).","journal-title":"iScience"},{"key":"1786_CR10","doi-asserted-by":"publisher","first-page":"e1009013","DOI":"10.1371\/journal.ppat.1009013","volume":"16","author":"A Pi\u0161lar","year":"2020","unstructured":"Pi\u0161lar, A. et al. The role of cysteine peptidases in coronavirus cell entry and replication: the therapeutic potential of cathepsin inhibitors. PLoS Pathog. 16, e1009013 (2020).","journal-title":"PLoS Pathog."},{"key":"1786_CR11","doi-asserted-by":"publisher","first-page":"eabg3055","DOI":"10.1126\/science.abg3055","volume":"372","author":"NG Davies","year":"2021","unstructured":"Davies, N. G. et al. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science 372, eabg3055 (2021).","journal-title":"Science"},{"key":"1786_CR12","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/s41586-020-2895-3","volume":"592","author":"JA Plante","year":"2021","unstructured":"Plante, J. A. et al. Spike mutation D614G alters SARS-CoV-2 fitness. Nature 592, 116\u2013121 (2021).","journal-title":"Nature"},{"key":"1786_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103112","volume":"62","author":"R Lorenzo-Redondo","year":"2020","unstructured":"Lorenzo-Redondo, R. et al. A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways. EBioMedicine 62, 103112 (2020).","journal-title":"EBioMedicine"},{"key":"1786_CR14","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1126\/science.abn8939","volume":"377","author":"S Yuan","year":"2022","unstructured":"Yuan, S. et al. Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters. Science 377, 428\u2013433 (2022).","journal-title":"Science"},{"key":"1786_CR15","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.cell.2020.06.043","volume":"182","author":"B Korber","year":"2020","unstructured":"Korber, B. et al. Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus. Cell 182, 812\u2013827.e19 (2020).","journal-title":"Cell"},{"key":"1786_CR16","doi-asserted-by":"publisher","first-page":"ii25","DOI":"10.1093\/jac\/dkad309","volume":"78","author":"R Lorenzo-Redondo","year":"2023","unstructured":"Lorenzo-Redondo, R., de Sant\u2019Anna Carvalho, A. M., Hultquist, J. F. & Ozer, E. A. SARS-CoV-2 genomics and impact on clinical care for COVID-19. J. Antimicrob. Chemother. 78, ii25\u2013ii36 (2023).","journal-title":"J. Antimicrob. Chemother."},{"key":"1786_CR17","first-page":"162","volume":"21","author":"AM Carabelli","year":"2023","unstructured":"Carabelli, A. M. et al. SARS-CoV-2 variant biology: immune escape, transmission and fitness. Nat. Rev. Microbiol. 21, 162\u2013177 (2023).","journal-title":"Nat. Rev. Microbiol."},{"key":"1786_CR18","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.cell.2020.09.032","volume":"183","author":"L Yurkovetskiy","year":"2020","unstructured":"Yurkovetskiy, L. et al. Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant. Cell 183, 739\u2013751.e8 (2020).","journal-title":"Cell"},{"key":"1786_CR19","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1126\/science.abe8499","volume":"370","author":"YJ Hou","year":"2020","unstructured":"Hou, Y. J. et al. SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo. Science 370, 1464\u20131468 (2020).","journal-title":"Science"},{"key":"1786_CR20","doi-asserted-by":"publisher","first-page":"110829","DOI":"10.1016\/j.celrep.2022.110829","volume":"39","author":"Y Liu","year":"2022","unstructured":"Liu, Y. et al. Delta spike P681R mutation enhances SARS-CoV-2 fitness over alpha variant. Cell Rep. 39, 110829 (2022).","journal-title":"Cell Rep."},{"key":"1786_CR21","doi-asserted-by":"publisher","first-page":"msab327","DOI":"10.1093\/molbev\/msab327","volume":"39","author":"YA Chan","year":"2022","unstructured":"Chan, Y. A. & Zhan, S. H. The emergence of the spike furin cleavage site in SARS-CoV-2. Mol. Biol. Evol. 39, msab327 (2022).","journal-title":"Mol. Biol. Evol."},{"key":"1786_CR22","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01751-20","volume":"95","author":"S Liu","year":"2021","unstructured":"Liu, S. et al. The PRRA insert at the S1\/S2 site modulates cellular tropism of SARS-CoV-2 and ACE2 usage by the closely related Bat RaTG13. J. Virol. 95, e01751-20 (2021).","journal-title":"J. Virol."},{"key":"1786_CR23","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41586-021-03237-4","volume":"591","author":"BA Johnson","year":"2021","unstructured":"Johnson, B. A. et al. Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis. Nature 591, 293\u2013299 (2021).","journal-title":"Nature"},{"key":"1786_CR24","doi-asserted-by":"publisher","first-page":"109664","DOI":"10.1016\/j.celrep.2021.109664","volume":"36","author":"T Dangi","year":"2021","unstructured":"Dangi, T., Class, J., Palacio, N., Richner, J. M. & Penaloza MacMaster, P. Combining spike- and nucleocapsid-based vaccines improves distal control of SARS-CoV-2. Cell Rep. 36, 109664 (2021).","journal-title":"Cell Rep."},{"key":"1786_CR25","doi-asserted-by":"publisher","first-page":"e162282","DOI":"10.1172\/JCI162282","volume":"132","author":"T Dangi","year":"2022","unstructured":"Dangi, T. et al. Improved control of SARS-CoV-2 by treatment with a nucleocapsid-specific monoclonal antibody. J. Clin. Invest. 132, e162282 (2022).","journal-title":"J. Clin. Invest."},{"key":"1786_CR26","doi-asserted-by":"publisher","first-page":"112167","DOI":"10.1016\/j.celrep.2023.112167","volume":"42","author":"T Dangi","year":"2023","unstructured":"Dangi, T. et al. Pre-existing immunity modulates responses to mRNA boosters. Cell Rep. 42, 112167 (2023).","journal-title":"Cell Rep."},{"key":"1786_CR27","doi-asserted-by":"crossref","unstructured":"Sanchez, S., Palacio, N., Dangi, T., Ciucci, T. & Penaloza-MacMaster, P. Fractionating a COVID-19 Ad5-vectored vaccine improves virus-specific immunity. Sci. Immunol. 6, eabi8635 (2021).","DOI":"10.1126\/sciimmunol.abi8635"},{"key":"1786_CR28","doi-asserted-by":"publisher","first-page":"e151969","DOI":"10.1172\/JCI151969","volume":"131","author":"T Dangi","year":"2021","unstructured":"Dangi, T. et al. Cross-protective immunity following coronavirus vaccination and coronavirus infection. J. Clin. Invest. 131, e151969 (2021).","journal-title":"J. Clin. Invest."},{"key":"1786_CR29","doi-asserted-by":"publisher","first-page":"ofac192","DOI":"10.1093\/ofid\/ofac192","volume":"9","author":"R Ke","year":"2022","unstructured":"Ke, R. et al. Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveals limited infectious virus shedding and restricted tissue distribution. Open Forum Infect. Dis. 9, ofac192 (2022).","journal-title":"Open Forum Infect. Dis."},{"key":"1786_CR30","doi-asserted-by":"publisher","first-page":"ofac027","DOI":"10.1093\/ofid\/ofac027","volume":"9","author":"LM Simons","year":"2022","unstructured":"Simons, L. M. et al. Assessment of virological contributions to COVID-19 outcomes in a longitudinal cohort of hospitalized adults. Open Forum Infect. Dis. 9, ofac027 (2022).","journal-title":"Open Forum Infect. Dis."},{"key":"1786_CR31","doi-asserted-by":"publisher","first-page":"e13914","DOI":"10.1111\/tid.13914","volume":"24","author":"LM Simons","year":"2022","unstructured":"Simons, L. M. et al. De novo emergence of SARS-CoV-2 spike mutations in immunosuppressed patients. Transpl. Infect. Dis. 24, e13914 (2022).","journal-title":"Transpl. Infect. Dis."},{"key":"1786_CR32","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1038\/s41590-020-0778-2","volume":"21","author":"ES Winkler","year":"2020","unstructured":"Winkler, E. S. et al. SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function. Nat. Immunol. 21, 1327\u20131335 (2020).","journal-title":"Nat. Immunol."},{"key":"1786_CR33","doi-asserted-by":"publisher","first-page":"e0096421","DOI":"10.1128\/JVI.00964-21","volume":"96","author":"W Dong","year":"2022","unstructured":"Dong, W. et al. The K18-Human ACE2 transgenic mouse model recapitulates non-severe and severe COVID-19 in response to an infectious dose of the SARS-CoV-2 virus. J. Virol. 96, e0096421 (2022).","journal-title":"J. Virol."},{"key":"1786_CR34","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.cell.2020.09.050","volume":"183","author":"SR Leist","year":"2020","unstructured":"Leist, S. R. et al. A mouse-adapted SARS-CoV-2 induces acute lung injury and mortality in standard laboratory mice. Cell 183, 1070\u20131085.e12 (2020).","journal-title":"Cell"},{"key":"1786_CR35","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1002\/jmv.27539","volume":"94","author":"MG Hossain","year":"2022","unstructured":"Hossain, M. G., Tang, Y.-D., Akter, S. & Zheng, C. Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccination. J. Med. Virol. 94, 1815\u20131820 (2022).","journal-title":"J. Med. Virol."},{"key":"1786_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-020-00662-x","volume":"9","author":"M-Y Li","year":"2020","unstructured":"Li, M.-Y., Li, L., Zhang, Y. & Wang, X.-S. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infect. Dis. Poverty 9, 45 (2020).","journal-title":"Infect. Dis. Poverty"},{"key":"1786_CR37","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s10096-020-04089-y","volume":"40","author":"F Piva","year":"2021","unstructured":"Piva, F., Sabanovic, B., Cecati, M. & Giulietti, M. Expression and co-expression analyses of TMPRSS2, a key element in COVID-19. Eur. J. Clin. Microbiol. Infect. Dis. 40, 451\u2013455 (2021).","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"1786_CR38","doi-asserted-by":"publisher","first-page":"101615","DOI":"10.1016\/j.redox.2020.101615","volume":"36","author":"E Gkogkou","year":"2020","unstructured":"Gkogkou, E., Barnasas, G., Vougas, K. & Trougakos, I. P. Expression profiling meta-analysis of ACE2 and TMPRSS2, the putative anti-inflammatory receptor and priming protease of SARS-CoV-2 in human cells, and identification of putative modulators. Redox Biol. 36, 101615 (2020).","journal-title":"Redox Biol."},{"key":"1786_CR39","doi-asserted-by":"publisher","first-page":"e08089","DOI":"10.1016\/j.heliyon.2021.e08089","volume":"7","author":"K Prasad","year":"2021","unstructured":"Prasad, K., Ahamad, S., Gupta, D. & Kumar, V. Targeting cathepsins: A potential link between COVID-19 and associated neurological manifestations. Heliyon 7, e08089 (2021).","journal-title":"Heliyon"},{"key":"1786_CR40","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/s41594-020-0468-7","volume":"27","author":"AG Wrobel","year":"2020","unstructured":"Wrobel, A. G. et al. SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects. Nat. Struct. Mol. Biol. 27, 763\u2013767 (2020).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"1786_CR41","doi-asserted-by":"publisher","first-page":"e1005261","DOI":"10.1371\/journal.ppat.1005261","volume":"11","author":"A Le Coupanec","year":"2015","unstructured":"Le Coupanec, A. et al. Cleavage of a neuroinvasive human respiratory virus spike glycoprotein by proprotein convertases modulates neurovirulence and virus spread within the central nervous system. PLoS Pathog. 11, e1005261 (2015).","journal-title":"PLoS Pathog."},{"key":"1786_CR42","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1128\/JVI.01863-09","volume":"84","author":"G Schnell","year":"2010","unstructured":"Schnell, G., Price, R. W., Swanstrom, R. & Spudich, S. Compartmentalization and clonal amplification of HIV-1 variants in the cerebrospinal fluid during primary infection. J. Virol. 84, 2395\u20132407 (2010).","journal-title":"J. Virol."},{"key":"1786_CR43","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1006\/viro.1995.1265","volume":"209","author":"C Adami","year":"1995","unstructured":"Adami, C. et al. Evolution of mouse hepatitis virus (MHV) during chronic infection: quasispecies nature of the persisting MHV RNA. Virology 209, 337\u2013346 (1995).","journal-title":"Virology"},{"key":"1786_CR44","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s11481-010-9202-2","volume":"5","author":"SJ Bender","year":"2010","unstructured":"Bender, S. J. & Weiss, S. R. Pathogenesis of murine coronavirus in the central nervous system. J. Neuroimmune Pharmacol. 5, 336\u2013354 (2010).","journal-title":"J. Neuroimmune Pharmacol."},{"key":"1786_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34256-y","volume":"14","author":"E Normandin","year":"2023","unstructured":"Normandin, E. et al. High-depth sequencing characterization of viral dynamics across tissues in fatal COVID-19 reveals compartmentalized infection. Nat. Commun. 14, 574 (2023).","journal-title":"Nat. Commun."},{"key":"1786_CR46","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.3390\/v13122511","volume":"13","author":"A Bertelli","year":"2021","unstructured":"Bertelli, A. et al. Role of Q675H mutation in improving SARS-CoV-2 spike interaction with the furin binding pocket. Viruses 13, 2511 (2021).","journal-title":"Viruses"},{"key":"1786_CR47","doi-asserted-by":"publisher","first-page":"102608","DOI":"10.1016\/j.conb.2022.102608","volume":"76","author":"A Vanderheiden","year":"2022","unstructured":"Vanderheiden, A. & Klein, R. S. Neuroinflammation and COVID-19. Curr. Opin. Neurobiol. 76, 102608 (2022).","journal-title":"Curr. Opin. Neurobiol."},{"key":"1786_CR48","doi-asserted-by":"publisher","first-page":"931","DOI":"10.4049\/jimmunol.2001400","volume":"206","author":"V Joag","year":"2021","unstructured":"Joag, V. et al. Cutting edge: mouse SARS-CoV-2 epitope reveals infection and vaccine-elicited CD8 T cell responses. J. Immunol. 206, 931\u2013935 (2021).","journal-title":"J. Immunol."},{"key":"1786_CR49","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/j.cell.2017.02.017","volume":"168","author":"JM Richner","year":"2017","unstructured":"Richner, J. M. et al. Modified mRNA vaccines protect against Zika virus infection. Cell 168, 1114\u20131125 (2017).","journal-title":"Cell"}],"container-title":["Nature Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41564-024-01786-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-024-01786-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-024-01786-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T11:10:21Z","timestamp":1725361821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41564-024-01786-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":49,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["1786"],"URL":"https:\/\/doi.org\/10.1038\/s41564-024-01786-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3220157\/v1","asserted-by":"object"}]},"ISSN":["2058-5276"],"issn-type":[{"value":"2058-5276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]},"assertion":[{"value":"31 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"J.F.H. has received research support paid to Northwestern University from Gilead Sciences and is a paid consultant for Merck. All other authors declare no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}