{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:58:02Z","timestamp":1785452282221,"version":"3.56.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572567"],"award-info":[{"award-number":["82572567"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372252"],"award-info":[{"award-number":["82372252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172270"],"award-info":[{"award-number":["82172270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Microbiol"],"DOI":"10.1038\/s41564-026-02411-6","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T09:02:17Z","timestamp":1784538137000},"page":"2279-2293","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["All-trans retinoic acid suppresses systemic inflammation induced by severe fever with thrombocytopenia syndrome virus in mice"],"prefix":"10.1038","volume":"11","author":[{"given":"Xin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjia","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfa","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5406-4195","authenticated-orcid":false,"given":"Jinyan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9505-1307","authenticated-orcid":false,"given":"Xiaoai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-You","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1948-2798","authenticated-orcid":false,"given":"Shuxian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6280-267X","authenticated-orcid":false,"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6937-2430","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2919-5473","authenticated-orcid":false,"given":"Shu Jeffrey","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"2411_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1146\/annurev.nutr.25.050304.092614","volume":"25","author":"EH Harrison","year":"2005","unstructured":"Harrison, E. H. Mechanisms of digestion and absorption of dietary vitamin A. Annu. Rev. Nutr. 25, 87\u2013103 (2005).","journal-title":"Annu. Rev. Nutr."},{"key":"2411_CR2","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1002\/neu.20242","volume":"66","author":"R Blomhoff","year":"2006","unstructured":"Blomhoff, R. & Blomhoff, H. K. Overview of retinoid metabolism and function. J. Neurobiol. 66, 606\u2013630 (2006).","journal-title":"J. Neurobiol."},{"key":"2411_CR3","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1301\/nr.2007.aug.385-388","volume":"65","author":"G Wolf","year":"2007","unstructured":"Wolf, G. Identification of a membrane receptor for retinol-binding protein functioning in the cellular uptake of retinol. Nutr. Rev. 65, 385\u2013388 (2007).","journal-title":"Nutr. Rev."},{"key":"2411_CR4","doi-asserted-by":"publisher","first-page":"7135","DOI":"10.1073\/pnas.1231422100","volume":"100","author":"FA Mic","year":"2003","unstructured":"Mic, F. A., Molotkov, A., Benbrook, D. M. & Duester, G. Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis. Proc. Natl Acad. Sci. USA 100, 7135\u20137140 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2411_CR5","doi-asserted-by":"publisher","first-page":"107400","DOI":"10.1016\/j.pharmthera.2019.107400","volume":"204","author":"N Isoherranen","year":"2019","unstructured":"Isoherranen, N. & Zhong, G. Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases. Pharmacol. Ther. 204, 107400 (2019).","journal-title":"Pharmacol. Ther."},{"key":"2411_CR6","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.it.2016.12.006","volume":"38","author":"MN Erkelens","year":"2017","unstructured":"Erkelens, M. N. & Mebius, R. E. Retinoic acid and immune homeostasis: a balancing act. Trends Immunol. 38, 168\u2013180 (2017).","journal-title":"Trends Immunol."},{"key":"2411_CR7","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1194\/jlr.R030833","volume":"54","author":"Z Al Tanoury","year":"2013","unstructured":"Al Tanoury, Z., Piskunov, A. & Rochette-Egly, C. Vitamin A and retinoid signaling: genomic and nongenomic effects. J. Lipid Res. 54, 1761\u20131775 (2013).","journal-title":"J. Lipid Res."},{"key":"2411_CR8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/34178","volume":"391","author":"M Ricote","year":"1998","unstructured":"Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J. & Glass, C. K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391, 79\u201382 (1998).","journal-title":"Nature"},{"key":"2411_CR9","doi-asserted-by":"publisher","first-page":"102397","DOI":"10.1016\/j.coi.2023.102397","volume":"85","author":"D Schnoegl","year":"2023","unstructured":"Schnoegl, D., Hiesinger, A., Huntington, N. D. & Gotthardt, D. AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity. Curr. Opin. Immunol. 85, 102397 (2023).","journal-title":"Curr. Opin. Immunol."},{"key":"2411_CR10","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nri3495","volume":"13","author":"JS Arthur","year":"2013","unstructured":"Arthur, J. S. & Ley, S. C. Mitogen-activated protein kinases in innate immunity. Nat. Rev. Immunol. 13, 679\u2013692 (2013).","journal-title":"Nat. Rev. Immunol."},{"key":"2411_CR11","first-page":"CD008524","volume":"12","author":"A Imdad","year":"2010","unstructured":"Imdad, A., Herzer, K., Mayo-Wilson, E., Yakoob, M.Y. & Bhutta, Z.A. Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age. Cochrane Database Syst. Rev. 12, CD008524 (2010).","journal-title":"Cochrane Database Syst. Rev."},{"key":"2411_CR12","first-page":"CD008666","volume":"2015","author":"ME McCauley","year":"2015","unstructured":"McCauley, M. E., van den Broek, N., Dou, L. & Othman, M. Vitamin A supplementation during pregnancy for maternal and newborn outcomes. Cochrane Database Syst. Rev. 2015, CD008666 (2015).","journal-title":"Cochrane Database Syst. Rev."},{"key":"2411_CR13","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1093\/jn\/nxz142","volume":"149","author":"AR Aluisio","year":"2019","unstructured":"Aluisio, A. R. et al. Vitamin A supplementation was associated with reduced mortality in patients with Ebola virus disease during the West African outbreak. J. Nutr. 149, 1757\u20131765 (2019).","journal-title":"J. Nutr."},{"key":"2411_CR14","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1056\/NEJM199007193230304","volume":"323","author":"GD Hussey","year":"1990","unstructured":"Hussey, G. D. & Klein, M. A randomized, controlled trial of vitamin A in children with severe measles. N. Engl. J. Med. 323, 160\u2013164 (1990).","journal-title":"N. Engl. J. Med."},{"key":"2411_CR15","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1002\/oby.22929","volume":"28","author":"RR Penkert","year":"2020","unstructured":"Penkert, R. R. et al. Vitamin A corrects tissue deficits in diet-induced obese mice and reduces influenza infection after vaccination and challenge. Obesity 28, 1631\u20131636 (2020).","journal-title":"Obesity"},{"key":"2411_CR16","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/00006454-199902000-00009","volume":"18","author":"WW Fawzi","year":"1999","unstructured":"Fawzi, W. W. et al. A randomized trial of vitamin A supplements in relation to mortality among human immunodeficiency virus-infected and uninfected children in Tanzania. Pediatr. Infect. Dis. J. 18, 127\u2013133 (1999).","journal-title":"Pediatr. Infect. Dis. J."},{"key":"2411_CR17","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1056\/NEJMoa1010095","volume":"364","author":"XJ Yu","year":"2011","unstructured":"Yu, X. J. et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. N. Engl. J. Med. 364, 1523\u20131532 (2011).","journal-title":"N. Engl. J. Med."},{"key":"2411_CR18","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.imj.2021.10.001","volume":"1","author":"JC Li","year":"2022","unstructured":"Li, J. C., Zhao, J., Li, H., Fang, L. Q. & Liu, W. Epidemiology, clinical characteristics, and treatment of severe fever with thrombocytopenia syndrome. Infect. Med. 1, 40\u201349 (2022).","journal-title":"Infect. Med."},{"key":"2411_CR19","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.3201\/eid2110.150126","volume":"21","author":"LM Luo","year":"2015","unstructured":"Luo, L. M. et al. Haemaphysalis longicornis ticks as reservoir and vector of severe fever with thrombocytopenia syndrome virus in China. Emerg. Infect. Dis. 21, 1770\u20131776 (2015).","journal-title":"Emerg. Infect. Dis."},{"key":"2411_CR20","doi-asserted-by":"publisher","first-page":"867","DOI":"10.3201\/eid2405.151435","volume":"24","author":"L Zhuang","year":"2018","unstructured":"Zhuang, L. et al. Transmission of severe fever with thrombocytopenia syndrome virus by Haemaphysalis longicornis ticks, China. Emerg. Infect. Dis. 24, 867\u2013871 (2018).","journal-title":"Emerg. Infect. Dis."},{"key":"2411_CR21","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jinf.2014.08.001","volume":"70","author":"N Cui","year":"2015","unstructured":"Cui, N. et al. Severe fever with thrombocytopenia syndrome bunyavirus-related human encephalitis. J. Infect. 70, 52\u201359 (2015).","journal-title":"J. Infect."},{"key":"2411_CR22","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.3201\/eid1911.130792","volume":"19","author":"KH Kim","year":"2013","unstructured":"Kim, K. H. et al. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg. Infect. Dis. 19, 1892\u20131894 (2013).","journal-title":"Emerg. Infect. Dis."},{"key":"2411_CR23","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1093\/infdis\/jit603","volume":"209","author":"T Takahashi","year":"2014","unstructured":"Takahashi, T. et al. The first identification and retrospective study of severe fever with thrombocytopenia syndrome in Japan. J. Infect. Dis. 209, 816\u2013827 (2014).","journal-title":"J. Infect. Dis."},{"key":"2411_CR24","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1093\/jn\/117.5.857","volume":"117","author":"SM Smith","year":"1987","unstructured":"Smith, S. M., Levy, N. S. & Hayes, C. E. Impaired immunity in vitamin A-deficient mice. J. Nutr. 117, 857\u2013865 (1987).","journal-title":"J. Nutr."},{"key":"2411_CR25","doi-asserted-by":"publisher","first-page":"7674","DOI":"10.1074\/jbc.274.12.7674","volume":"274","author":"SY Na","year":"1999","unstructured":"Na, S. Y. et al. Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NF\u03baB. J. Biol. Chem. 274, 7674\u20137680 (1999).","journal-title":"J. Biol. Chem."},{"key":"2411_CR26","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1097\/00003226-199403000-00009","volume":"13","author":"NB Shams","year":"1994","unstructured":"Shams, N. B. et al. Increased interleukin-1 activity in the injured vitamin A-deficient cornea. Cornea 13, 156\u2013166 (1994).","journal-title":"Cornea"},{"key":"2411_CR27","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41564-022-01279-6","volume":"8","author":"J Xie","year":"2023","unstructured":"Xie, J. et al. Akkermansia muciniphila protects mice against an emerging tick-borne viral pathogen. Nat. Microbiol. 8, 91\u2013106 (2023).","journal-title":"Nat. Microbiol."},{"key":"2411_CR28","doi-asserted-by":"publisher","first-page":"4370","DOI":"10.1016\/j.celrep.2020.02.105","volume":"30","author":"S Li","year":"2020","unstructured":"Li, S. et al. SFTSV infection induces BAK\/BAX-dependent mitochondrial DNA release to trigger NLRP3 inflammasome activation. Cell Rep. 30, 4370\u20134385 e4377 (2020).","journal-title":"Cell Rep."},{"key":"2411_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110039","volume":"37","author":"H Li","year":"2021","unstructured":"Li, H. et al. Single-cell landscape of peripheral immune responses to fatal SFTS. Cell Rep. 37, 110039 (2021).","journal-title":"Cell Rep."},{"key":"2411_CR30","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3390\/nu9010068","volume":"9","author":"P Czarnewski","year":"2017","unstructured":"Czarnewski, P., Das, S., Parigi, S. M. & Villablanca, E. J. Retinoic acid and its role in modulating intestinal innate immunity. Nutrients 9, 68 (2017).","journal-title":"Nutrients"},{"key":"2411_CR31","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1038\/nature05894","volume":"447","author":"JI Odegaard","year":"2007","unstructured":"Odegaard, J. I. et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447, 1116\u20131120 (2007).","journal-title":"Nature"},{"key":"2411_CR32","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.immuni.2010.11.009","volume":"33","author":"A Szanto","year":"2010","unstructured":"Szanto, A. et al. STAT6 transcription factor is a facilitator of the nuclear receptor PPARgamma-regulated gene expression in macrophages and dendritic cells. Immunity 33, 699\u2013712 (2010).","journal-title":"Immunity"},{"key":"2411_CR33","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.immuni.2018.09.005","volume":"49","author":"B Daniel","year":"2018","unstructured":"Daniel, B. et al. The nuclear receptor PPAR\u03b3 controls progressive macrophage polarization as a ligand-insensitive epigenomic ratchet of transcriptional memory. Immunity 49, 615\u2013626.e6 (2018).","journal-title":"Immunity"},{"key":"2411_CR34","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.it.2007.09.003","volume":"28","author":"DS Straus","year":"2007","unstructured":"Straus, D. S. & Glass, C. K. Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol. 28, 551\u2013558 (2007).","journal-title":"Trends Immunol."},{"key":"2411_CR35","doi-asserted-by":"publisher","first-page":"32048","DOI":"10.1074\/jbc.274.45.32048","volume":"274","author":"P Delerive","year":"1999","unstructured":"Delerive, P. et al. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. J. Biol. Chem. 274, 32048\u201332054 (1999).","journal-title":"J. Biol. Chem."},{"key":"2411_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.107942","volume":"169","author":"J Huang","year":"2024","unstructured":"Huang, J. et al. All-trans retinoic acid acts as a dual-purpose inhibitor of SARS-CoV-2 infection and inflammation. Comput. Biol. Med. 169, 107942 (2024).","journal-title":"Comput. Biol. Med."},{"key":"2411_CR37","doi-asserted-by":"publisher","first-page":"L340","DOI":"10.1152\/ajplung.90267.2008","volume":"297","author":"L Moreno-Vinasco","year":"2009","unstructured":"Moreno-Vinasco, L., Verbout, N. G., Fryer, A. D. & Jacoby, D. B. Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects. Am. J. Physiol. Lung Cell. Mol. Physiol. 297, L340\u2013L346 (2009).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2411_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.734171","volume":"13","author":"J Pu","year":"2022","unstructured":"Pu, J. et al. All-trans retinoic acid attenuates transmissible gastroenteritis virus-induced inflammation in IPEC-J2 cells via suppressing the RLRs\/NF-\u03baB signaling pathway. Front. Immunol. 13, 734171 (2022).","journal-title":"Front. Immunol."},{"key":"2411_CR39","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1001\/archpedi.1996.02170260029004","volume":"150","author":"KP Quinlan","year":"1996","unstructured":"Quinlan, K. P. & Hayani, K. C. Vitamin A and respiratory syncytial virus infection. Serum levels and supplementation trial. Arch. Pediatr. Adolesc. Med. 150, 25\u201330 (1996).","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"2411_CR40","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.3390\/nu13072173","volume":"13","author":"PR Tepasse","year":"2021","unstructured":"Tepasse, P. R. et al. Vitamin A plasma levels in COVID-19 patients: a prospective multicenter study and hypothesis. Nutrients 13, 2173 (2021).","journal-title":"Nutrients"},{"key":"2411_CR41","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1002\/pmic.201300180","volume":"13","author":"X Wu","year":"2013","unstructured":"Wu, X. et al. Subcellular proteomic analysis of human host cells infected with H3N2 swine influenza virus. Proteomics 13, 3309\u20133326 (2013).","journal-title":"Proteomics"},{"key":"2411_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-024-06775-y","volume":"17","author":"RS Martins","year":"2024","unstructured":"Martins, R. S. et al. Gene expression profiles in COVID-19-associated tracheal stenosis indicate persistent anti-viral response and dysregulated retinol metabolism. BMC Res. Notes 17, 140 (2024).","journal-title":"BMC Res. Notes"},{"key":"2411_CR43","doi-asserted-by":"publisher","first-page":"8317","DOI":"10.1074\/jbc.M608667200","volume":"282","author":"RJ Jones","year":"2007","unstructured":"Jones, R. J., Dickerson, S., Bhende, P. M., Delecluse, H. J. & Kenney, S. C. Epstein\u2013Barr virus lytic infection induces retinoic acid-responsive genes through induction of a retinol-metabolizing enzyme, DHRS9. J. Biol. Chem. 282, 8317\u20138324 (2007).","journal-title":"J. Biol. Chem."},{"key":"2411_CR44","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40104-023-00978-2","volume":"15","author":"J Pu","year":"2024","unstructured":"Pu, J. et al. All-trans retinoic acid alleviates transmissible gastroenteritis virus-induced intestinal inflammation and barrier dysfunction in weaned piglets. J. Anim. Sci. Biotechnol. 15, 22 (2024).","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"2411_CR45","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","volume":"62","author":"M Pawlak","year":"2015","unstructured":"Pawlak, M., Lefebvre, P. & Staels, B. Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. J. Hepatol. 62, 720\u2013733 (2015).","journal-title":"J. Hepatol."},{"key":"2411_CR46","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.virusres.2012.12.018","volume":"173","author":"I Galindo-Cardiel","year":"2013","unstructured":"Galindo-Cardiel, I. et al. Standardization of pathological investigations in the framework of experimental ASFV infections. Virus Res. 173, 180\u2013190 (2013).","journal-title":"Virus Res."},{"key":"2411_CR47","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nm.4453","volume":"24","author":"P Zhang","year":"2018","unstructured":"Zhang, P. et al. The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis. Nat. Med. 24, 84\u201394 (2018).","journal-title":"Nat. Med."},{"key":"2411_CR48","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.3389\/fphar.2019.01600","volume":"10","author":"C Shen","year":"2019","unstructured":"Shen, C. et al. Rhein suppresses lung inflammatory injury induced by human respiratory syncytial virus through inhibiting NLRP3 inflammasome activation via NF-\u03baB pathway in mice. Front. Pharmacol. 10, 1600 (2019).","journal-title":"Front. Pharmacol."},{"key":"2411_CR49","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.107","volume":"2","author":"S Chen","year":"2023","unstructured":"Chen, S. Ultrafast one-pass FASTQ data preprocessing, quality control, and deduplication using fastp. Imeta 2, e107 (2023).","journal-title":"Imeta"},{"key":"2411_CR50","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","volume":"37","author":"D Kim","year":"2019","unstructured":"Kim, D., Paggi, J. M., Park, C., Bennett, C. & Salzberg, S. L. Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat. Biotechnol. 37, 907\u2013915 (2019).","journal-title":"Nat. Biotechnol."},{"key":"2411_CR51","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-323","volume":"12","author":"B Li","year":"2011","unstructured":"Li, B. & Dewey, C. N. RSEM: accurate transcript quantification from RNA-seq data with or without a reference genome. BMC Bioinform. 12, 323 (2011).","journal-title":"BMC Bioinform."},{"key":"2411_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."},{"key":"2411_CR53","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu, T. et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation 2, 100141 (2021).","journal-title":"Innovation"},{"key":"2411_CR54","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/hep.29786","volume":"68","author":"Z Zhao","year":"2018","unstructured":"Zhao, Z. et al. Hepatic PPAR\u03b1 function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1. Hepatology 68, 289\u2013303 (2018).","journal-title":"Hepatology"},{"key":"2411_CR55","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ab.2011.02.032","volume":"414","author":"L Gijsbers","year":"2011","unstructured":"Gijsbers, L. et al. Stable reporter cell lines for peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3)-mediated modulation of gene expression. Anal. Biochem. 414, 77\u201383 (2011).","journal-title":"Anal. Biochem."}],"container-title":["Nature Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41564-026-02411-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-026-02411-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41564-026-02411-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:04:19Z","timestamp":1785449059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41564-026-02411-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":55,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["2411"],"URL":"https:\/\/doi.org\/10.1038\/s41564-026-02411-6","relation":{},"ISSN":["2058-5276"],"issn-type":[{"value":"2058-5276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,20]]},"assertion":[{"value":"1 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}