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The DmsABC enzymatic complex encodes one such DMSO reductase to promote oxidative stress resistance. The\n                    <jats:italic>Salmonella<\/jats:italic>\n                    genome encodes several gene paralogues but their role in virulence is unclear. Here we characterize three\n                    <jats:italic>Salmonella<\/jats:italic>\n                    MopB-family extracytoplasmic sulfate reductases, which we call Xsr1A, Xsr2A and Xsr3A. Infection experiments in mice and macrophages show that these sulfate reductases support\n                    <jats:italic>Salmonella<\/jats:italic>\n                    growth and virulence in the gut and during systemic infection, countering the oxidative effects of host respiratory burst activity. Further experiments show that they are molybdenum cofactor-independent enzymes, and instead depend on the nearby redox-active [4Fe\u20134S] prosthetic group for catalytic activity. Orthologues of these sulfate reductases were found across distant evolutionary branches, suggesting that [4Fe\u20134S]-dependent catalysis may occur across the ubiquitous MopB superfamily. Our findings offer insights into the modular evolution of redox centres in the widespread MopB superfamily.\n                  <\/jats:p>","DOI":"10.1038\/s41564-026-02443-y","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:01:11Z","timestamp":1785920471000},"page":"2619-2633","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Salmonella uses sulfate reductases with unique catalytic activity to promote gut colonization in mice"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7926-9560","authenticated-orcid":false,"given":"Ju-Sim","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4743-7248","authenticated-orcid":false,"given":"Siva","family":"Uppalapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4391-6727","authenticated-orcid":false,"given":"Alyssa","family":"Margolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1788-9347","authenticated-orcid":false,"given":"Michael","family":"McClelland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Elajaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Nozik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-3806","authenticated-orcid":false,"given":"Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-4185","authenticated-orcid":false,"given":"Andres","family":"Vazquez-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"2443_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0005-2728(97)00034-0","volume":"1320","author":"G Unden","year":"1997","unstructured":"Unden, G. & Bongaerts, J. 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