{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:55:48Z","timestamp":1782539748088,"version":"3.54.5"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature Nanotech"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1038\/s41565-018-0150-y","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T17:01:51Z","timestamp":1526662911000},"page":"578-582","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Single entity resolution valving of nanoscopic species in liquids"],"prefix":"10.1038","volume":"13","author":[{"given":"Patric","family":"Eberle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"H\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3276-3008","authenticated-orcid":false,"given":"Maarit","family":"Suomalainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-120X","authenticated-orcid":false,"given":"Urs F.","family":"Greber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Eghlidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimos","family":"Poulikakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,21]]},"reference":[{"key":"150_CR1","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.cell.2006.02.018","volume":"124","author":"UF Greber","year":"2006","unstructured":"Greber, U. F. & Way, M. A superhighway to virus infection. Cell 124, 741\u2013754 (2006).","journal-title":"Cell"},{"key":"150_CR2","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/nnano.2014.140","volume":"9","author":"Y Pang","year":"2014","unstructured":"Pang, Y., Song, H., Kim, J. H., Hou, X. & Cheng, W. Optical trapping of individual human immunodeficiency viruses in culture fluid reveals heterogeneity with single-molecule resolution. Nat. Nanotech. 9, 624\u2013630 (2014).","journal-title":"Nat. Nanotech."},{"key":"150_CR3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2217\/nnm.11.167","volume":"7","author":"E Amstad","year":"2012","unstructured":"Amstad, E. & Reimhult, E. Nanoparticle actuated hollow drug delivery vehicles. Nanomedicine 7, 145\u2013164 (2012).","journal-title":"Nanomedicine"},{"key":"150_CR4","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/nnano.2013.195","volume":"8","author":"CA Aguilar","year":"2013","unstructured":"Aguilar, C. A. & Craighead, H. G. Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics. Nat. Nanotech. 8, 709\u201318 (2013).","journal-title":"Nat. Nanotech."},{"key":"150_CR5","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nmeth.1218","volume":"5","author":"KC Neuman","year":"2008","unstructured":"Neuman, K. C. & Nagy, A. Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy. Nat. Methods 5, 491\u2013505 (2008).","journal-title":"Nat. Methods"},{"key":"150_CR6","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/nature01935","volume":"424","author":"DG Grier","year":"2003","unstructured":"Grier, D. G. A revolution in optical manipulation. Nature 424, 810\u2013816 (2003).","journal-title":"Nature"},{"key":"150_CR7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nnano.2014.24","volume":"9","author":"J Berthelot","year":"2014","unstructured":"Berthelot, J. et al. Three-dimensional manipulation with scanning near-field optical nanotweezers. Nat. Nanotech. 9, 295\u2013299 (2014).","journal-title":"Nat. Nanotech."},{"key":"150_CR8","doi-asserted-by":"publisher","first-page":"8937","DOI":"10.1073\/pnas.1103554108","volume":"108","author":"AP Fields","year":"2011","unstructured":"Fields, A. P. & Cohen, A. E. Electrokinetic trapping at the one nanometer limit. Proc. Natl Acad. Sci. USA 108, 8937\u20138942 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"150_CR9","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/nature09404","volume":"467","author":"M Krishnan","year":"2010","unstructured":"Krishnan, M., Mojarad, N., Kukura, P. & Sandoghdar, V. Geometry-induced electrostatic trapping of nanometric objects in a fluid. Nature 467, 692\u2013695 (2010).","journal-title":"Nature"},{"key":"150_CR10","doi-asserted-by":"publisher","first-page":"11105","DOI":"10.1073\/pnas.1209288109","volume":"109","author":"X Ding","year":"2012","unstructured":"Ding, X. et al. On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves. Proc. Natl Acad. Sci. USA 109, 11105\u201311109 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"150_CR11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1126\/science.288.5463.113","volume":"288","author":"MA Unger","year":"2000","unstructured":"Unger, M. A., Chou, H. P., Thorsen, T., Scherer, A. & Quake, S. R. Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 288, 113\u2013116 (2000).","journal-title":"Science"},{"key":"150_CR12","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1126\/science.1076996","volume":"298","author":"T Thorsen","year":"2002","unstructured":"Thorsen, T., Maerkl, S. J. & Quake, S. R. Microfluidic large-scale integration. Science 298, 580\u2013584 (2002).","journal-title":"Science"},{"key":"150_CR13","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/nrd3799","volume":"11","author":"P Neu\u017ei","year":"2012","unstructured":"Neu\u017ei, P., Giselbrecht, S., L\u00e4nge, K., Huang, T. J. & Manz, A. Revisiting lab-on-a-chip technology for drug discovery. Nat. Rev. Drug Discov. 11, 620\u2013632 (2012).","journal-title":"Nat. Rev. Drug Discov."},{"key":"150_CR14","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nnano.2012.168","volume":"7","author":"PM Valencia","year":"2012","unstructured":"Valencia, P. M., Farokhzad, O. C., Karnik, R. & Langer, R. Microfluidic technologies for accelerating the clinical translation of nanoparticles. Nat. Nanotech. 7, 623\u2013629 (2012).","journal-title":"Nat. Nanotech."},{"key":"150_CR15","unstructured":"Williams, R. J. P. & Frausto da Silva, J. J. R. The Natural Selection of the Chemical Elements: the Environment and Life\u2019s Chemistry (Clarendon Press, New York, 1996)."},{"key":"150_CR16","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1126\/science.1187292","volume":"329","author":"VS Reddy","year":"2010","unstructured":"Reddy, V. S., Natchiar, S. K., Stewart, P. L. & Nemerow, G. R. Crystal structure of human adenovirus at 3.5 A resolution. Science 329, 1071\u20131075 (2010).","journal-title":"Science"},{"key":"150_CR17","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1038\/nmeth.1395","volume":"6","author":"P Kukura","year":"2009","unstructured":"Kukura, P. et al. High-speed nanoscopic tracking of the position and orientation of a single virus. Nat. Methods 6, 923\u2013927 (2009).","journal-title":"Nat. Methods"},{"key":"150_CR18","unstructured":"Morgan, H. & Green, N. G. AC Electrokinetics: Colloids and Nanoparticles (Research Studies, Philadelphia, 2003)."},{"key":"150_CR19","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/nnano.2010.233","volume":"5","author":"C Duan","year":"2010","unstructured":"Duan, C. & Majumdar, A. Anomalous ion transport in 2-nm hydrophilic nanochannels. Nat. Nanotech. 5, 848\u2013852 (2010).","journal-title":"Nat. Nanotech."},{"key":"150_CR20","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nnano.2009.332","volume":"4","author":"W Sparreboom","year":"2009","unstructured":"Sparreboom, W., van den Berg, A. & Eijkel, J. C. T. Principles and applications of nanofluidic transport. Nat. Nanotech. 4, 713\u2013720 (2009).","journal-title":"Nat. Nanotech."},{"key":"150_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4380","volume":"5","author":"J Tae Kim","year":"2014","unstructured":"Tae Kim, J., Spindler, S. & Sandoghdar, V. Scanning-aperture trapping and manipulation of single charged nanoparticles. Nat. Commun. 5, 3380 (2014).","journal-title":"Nat. Commun."},{"key":"150_CR22","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/nnano.2017.26","volume":"12","author":"F Ruggeri","year":"2017","unstructured":"Ruggeri, F. et al. Single-molecule electrometry. Nat. Nanotech. 12, 488\u2013495 (2017).","journal-title":"Nat. Nanotech."},{"key":"150_CR23","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/S0031-8914(40)90098-2","volume":"7","author":"HA Kramers","year":"1940","unstructured":"Kramers, H. A. Brownian motion in a field of force and the diffusion model of chemical reactions. Physica 7, 284\u2013304 (1940).","journal-title":"Physica"},{"key":"150_CR24","doi-asserted-by":"publisher","first-page":"022811","DOI":"10.1063\/1.3456626","volume":"4","author":"R Pethig","year":"2010","unstructured":"Pethig, R. Dielectrophoresis: status of the theory, technology, and applications. Biomicrofluidics 4, 022811 (2010).","journal-title":"Biomicrofluidics"},{"key":"150_CR25","doi-asserted-by":"crossref","unstructured":"Young, G. et al. Quantitative mass imaging of single molecules in solution. Preprint at \n                    https:\/\/doi.org\/10.1101\/229740\n                    \n                   (2017).","DOI":"10.1101\/229740"},{"key":"150_CR26","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1103\/PhysRevE.71.041106","volume":"71","author":"T Savin","year":"2005","unstructured":"Savin, T. & Doyle, P. S. Role of a finite exposure time on measuring an elastic modulus using microrheology. Phys. Rev. E 71, 6\u201311 (2005).","journal-title":"Phys. Rev. E"},{"key":"150_CR27","doi-asserted-by":"publisher","first-page":"3375","DOI":"10.1103\/PhysRevLett.68.3375","volume":"68","author":"A Libchaber","year":"1992","unstructured":"Libchaber, A. & Simon, A. Escape and synchronization of a Brownian particle. Phys. Rev. Lett. 68, 3375\u20133378 (1992).","journal-title":"Phys. Rev. Lett."},{"key":"150_CR28","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nchem.545","volume":"2","author":"RH Goldsmith","year":"2010","unstructured":"Goldsmith, R. H. & Moerner, W. E. Watching conformational- and photodynamics of single fluorescent proteins in solution. Nat. Chem. 2, 179\u2013186 (2010).","journal-title":"Nat. Chem."},{"key":"150_CR29","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1126\/science.aal3271","volume":"359","author":"MJ Skaug","year":"2018","unstructured":"Skaug, M. J., Schwemmer, C., Fringes, S., Rawlings, C. D. & Knoll, A. W. Nanofluidic rocking Brownian motors. Science 359, 1505\u20131508 (2018).","journal-title":"Science"},{"key":"150_CR30","first-page":"217","volume":"21","author":"UF Greber","year":"1998","unstructured":"Greber, U. F., Nakano, M. Y. & Suomalainen, M. Adenovirus entry into cells: a quantitative fluorescence microscopy approach. Methods Mol. Med. 21, 217\u2013230 (1998).","journal-title":"Methods Mol. Med."},{"key":"150_CR31","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1099\/vir.0.83142-0","volume":"88","author":"C Fleischli","year":"2007","unstructured":"Fleischli, C. et al. Species B adenovirus serotypes 3, 7, 11 and 35 share similar binding sites on the membrane cofactor protein CD46 receptor. J. Gen. Virol. 88, 2925\u20132934 (2007).","journal-title":"J. Gen. Virol."},{"key":"150_CR32","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1038\/sj.gt.3302058","volume":"10","author":"H Nagel","year":"2003","unstructured":"Nagel, H. et al. The \u03b1v\u03b25 integrin of hematopoietic and nonhematopoietic cells is a transduction receptor of RGD-4C fiber-modified adenoviruses. Gene Ther. 10, 1643\u20131653 (2003).","journal-title":"Gene Ther."},{"key":"150_CR33","doi-asserted-by":"publisher","first-page":"12367","DOI":"10.1128\/JVI.01833-13","volume":"87","author":"M Suomalainen","year":"2013","unstructured":"Suomalainen, M. et al. A direct and versatile assay measuring membrane penetration of adenovirus in single cells. J. Virol. 87, 12367\u201379 (2013).","journal-title":"J. Virol."},{"key":"150_CR34","doi-asserted-by":"publisher","first-page":"9377","DOI":"10.1364\/OE.21.009377","volume":"21","author":"N Mojarad","year":"2013","unstructured":"Mojarad, N., Sandoghdar, V. & Krishnan, M. Measuring three-dimensional interaction potentials using optical interference. Opt. Express 21, 9377\u201389 (2013).","journal-title":"Opt. Express"},{"key":"150_CR35","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nnano.2012.99","volume":"7","author":"N Mojarad","year":"2012","unstructured":"Mojarad, N. & Krishnan, M. Measuring the size and charge of single nanoscale objects in solution using an electrostatic fluidic trap. Nat. Nanotech. 7, 448\u201352 (2012).","journal-title":"Nat. Nanotech."},{"key":"150_CR36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/0166-6622(90)80132-N","volume":"51","author":"T Overbeek","year":"1990","unstructured":"Overbeek, T. The role of energy and entropy in the electric double layer. Colloids Surfaces 51, 61\u201375 (1990).","journal-title":"Colloids Surfaces"},{"key":"150_CR37","doi-asserted-by":"publisher","first-page":"114906","DOI":"10.1063\/1.4795087","volume":"138","author":"M Krishnan","year":"2013","unstructured":"Krishnan, M. Electrostatic free energy for a confined nanoscale object in a fluid. J. Chem. Phys. 138, 114906 (2013).","journal-title":"J. Chem. Phys."},{"key":"150_CR38","doi-asserted-by":"publisher","first-page":"6716","DOI":"10.1063\/1.1404988","volume":"115","author":"SH Behrens","year":"2001","unstructured":"Behrens, S. H. & Grier, D. G. The charge of glass and silica surfaces. J. Chem. Phys. 115, 6716\u20136721 (2001).","journal-title":"J. Chem. Phys."},{"key":"150_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1103\/PhysRevE.70.021506","volume":"70","author":"MZ Bazant","year":"2004","unstructured":"Bazant, M. Z., Thornton, K. & Ajdari, A. Diffuse-charge dynamics in electrochemical systems. Phys. Rev. E 70, 1\u201324 (2004).","journal-title":"Phys. Rev. E"},{"key":"150_CR40","first-page":"137","volume":"4","author":"D Stein","year":"2004","unstructured":"Stein, D., Kruithof, M. & Dekker, C. Surface charge governed ion transport in nanofluidic channels. Phys. Rev. Lett. 4, 137\u2013142 (2004).","journal-title":"Phys. Rev. Lett."},{"key":"150_CR41","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1006\/jcis.2000.7152","volume":"232","author":"VN Shilov","year":"2000","unstructured":"Shilov, V. N. et al. Polarization of the electrical double layer. time evolution after application of an electric field. J. Colloid Interface Sci. 232, 141\u2013148 (2000).","journal-title":"J. Colloid Interface Sci."}],"container-title":["Nature Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41565-018-0150-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41565-018-0150-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41565-018-0150-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:54:21Z","timestamp":1684619661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41565-018-0150-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,21]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["150"],"URL":"https:\/\/doi.org\/10.1038\/s41565-018-0150-y","relation":{},"ISSN":["1748-3387","1748-3395"],"issn-type":[{"value":"1748-3387","type":"print"},{"value":"1748-3395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,21]]},"assertion":[{"value":"22 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}