{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T15:27:55Z","timestamp":1794065275355,"version":"4.8.0"},"reference-count":105,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1112432"],"award-info":[{"award-number":["GNT1112432"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1141551"],"award-info":[{"award-number":["GNT1141551"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Department of Education and Training | Australian Research Council","doi-asserted-by":"publisher","award":["DP200100475"],"award-info":[{"award-number":["DP200100475"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Department of Education and Training | Australian Research Council","doi-asserted-by":"publisher","award":["CE140100036"],"award-info":[{"award-number":["CE140100036"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat. Nanotechnol."],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1038\/s41565-020-00810-2","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T12:03:04Z","timestamp":1608552184000},"page":"37-46","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":294,"title":["Inducing immune tolerance with dendritic cell-targeting nanomedicines"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9478-2239","authenticated-orcid":false,"given":"Anna","family":"Cifuentes-Rius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-4694","authenticated-orcid":false,"given":"Anal","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1886-0039","authenticated-orcid":false,"given":"Daniel","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5611-4515","authenticated-orcid":false,"given":"Angus P. R.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-7804","authenticated-orcid":false,"given":"Nicolas H.","family":"Voelcker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"810_CR1","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3389\/fimmu.2018.00350","volume":"9","author":"H Hasegawa","year":"2018","unstructured":"Hasegawa, H. & Matsumoto, T. Mechanisms of tolerance induction by dendritic cells in vivo. Front. Immunol. 9, 350\u2013350 (2018).","journal-title":"Front. Immunol."},{"key":"810_CR2","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.3389\/fimmu.2017.01514","volume":"8","author":"C Obregon","year":"2017","unstructured":"Obregon, C., Kumar, R., Pascual, M. A., Vassalli, G. & Golshayan, D. Update on dendritic cell-induced immunological and clinical tolerance. Front. Immunol. 8, 1514 (2017).","journal-title":"Front. Immunol."},{"key":"810_CR3","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.4049\/jimmunol.1601629","volume":"198","author":"C Audiger","year":"2017","unstructured":"Audiger, C., Rahman, M. J., Yun, T. J., Tarbell, K. V. & Lesage, S. The importance of dendritic cells in maintaining immune tolerance. J. Immunol. 198, 2223 (2017).","journal-title":"J. Immunol."},{"key":"810_CR4","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1600-065X.2011.01015.x","volume":"241","author":"S Manicassamy","year":"2011","unstructured":"Manicassamy, S. & Pulendran, B. Dendritic cell control of tolerogenic responses. Immunol. Rev. 241, 206\u2013227 (2011).","journal-title":"Immunol. Rev."},{"key":"810_CR5","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nature01661","volume":"423","author":"GS Firestein","year":"2003","unstructured":"Firestein, G. S. Evolving concepts of rheumatoid arthritis. Nature 423, 356\u2013361 (2003).","journal-title":"Nature"},{"key":"810_CR6","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1056\/NEJMra052130","volume":"354","author":"EM Frohman","year":"2006","unstructured":"Frohman, E. M., Racke, M. K. & Raine, C. S. Multiple sclerosis\u2014the plaque and its pathogenesis. N. Engl. J. Med. 354, 942\u2013955 (2006).","journal-title":"N. Engl. J. Med."},{"key":"810_CR7","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/317355a0","volume":"317","author":"S Zamvil","year":"1985","unstructured":"Zamvil, S. et al. T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination. Nature 317, 355\u2013358 (1985).","journal-title":"Nature"},{"key":"810_CR8","doi-asserted-by":"publisher","unstructured":"Xing, Y. & Hogquist, K. A. T-cell tolerance: central and peripheral. Cold Spring Harb. Perspect. Biol. https:\/\/doi.org\/10.1101\/cshperspect.a006957 (2012).","DOI":"10.1101\/cshperspect.a006957"},{"key":"810_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0952-7915(96)80096-3","volume":"8","author":"RAB Ezekowitz","year":"1996","unstructured":"Ezekowitz, R. A. B. & Hoffmann, J. A. Innate immunity. Curr. Opin. Immunol. 8, 1\u20132 (1996).","journal-title":"Curr. Opin. Immunol."},{"key":"810_CR10","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/j.1600-065X.2008.00733.x","volume":"227","author":"B Beutler","year":"2009","unstructured":"Beutler, B. Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases. Immunol. Rev. 227, 248\u2013263 (2009).","journal-title":"Immunol. Rev."},{"key":"810_CR11","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1002\/embj.201488027","volume":"33","author":"M Dalod","year":"2014","unstructured":"Dalod, M., Chelbi, R., Malissen, B. & Lawrence, T. Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming. EMBO J. 33, 1104\u20131116 (2014).","journal-title":"EMBO J."},{"key":"810_CR12","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.clim.2011.11.011","volume":"142","author":"MA Boks","year":"2012","unstructured":"Boks, M. A. et al. IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction\u2014a comparative study of human clinical-applicable DC. Clin. Immunol. 142, 332\u2013342 (2012).","journal-title":"Clin. Immunol."},{"key":"810_CR13","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41578-019-0112-5","volume":"4","author":"CL Stabler","year":"2019","unstructured":"Stabler, C. L., Li, Y., Stewart, J. M. & Keselowsky, B. G. Engineering immunomodulatory biomaterials for type 1 diabetes. Nat. Rev. Mater. 4, 429\u2013450 (2019).","journal-title":"Nat. Rev. Mater."},{"key":"810_CR14","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/35100512","volume":"1","author":"WR Heath","year":"2001","unstructured":"Heath, W. R. & Carbone, F. R. Cross-presentation in viral immunity and self-tolerance. Nat. Rev. Immunol. 1, 126\u2013134 (2001).","journal-title":"Nat. Rev. Immunol."},{"key":"810_CR15","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1146\/annurev.immunol.21.120601.141110","volume":"21","author":"RH Schwartz","year":"2003","unstructured":"Schwartz, R. H. T cell anergy. Annu. Rev. Immunol. 21, 305\u2013334 (2003).","journal-title":"Annu. Rev. Immunol."},{"key":"810_CR16","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s41590-018-0120-4","volume":"19","author":"M Dominguez-Villar","year":"2018","unstructured":"Dominguez-Villar, M. & Hafler, D. A. Regulatory T cells in autoimmune disease. Nat. Immunol. 19, 665\u2013673 (2018).","journal-title":"Nat. Immunol."},{"key":"810_CR17","doi-asserted-by":"publisher","first-page":"3556","DOI":"10.4049\/jimmunol.0802972","volume":"182","author":"C Capini","year":"2009","unstructured":"Capini, C. et al. Antigen-specific suppression of inflammatory arthritis using liposomes. J. Immunol. 182, 3556\u20133565 (2009).","journal-title":"J. Immunol."},{"key":"810_CR18","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nri2868","volume":"10","author":"MF Bachmann","year":"2010","unstructured":"Bachmann, M. F. & Jennings, G. T. Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns. Nat. Rev. Immunol. 10, 787\u2013796 (2010).","journal-title":"Nat. Rev. Immunol."},{"key":"810_CR19","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1007\/s11095-016-1958-5","volume":"33","author":"D Bobo","year":"2016","unstructured":"Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J. & Corrie, S. R. Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date. Pharm. Res. 33, 2373\u20132387 (2016).","journal-title":"Pharm. Res."},{"key":"810_CR20","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/nri2132","volume":"7","author":"AE Morelli","year":"2007","unstructured":"Morelli, A. E. & Thomson, A. W. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat. Rev. Immunol. 7, 610\u2013621 (2007).","journal-title":"Nat. Rev. Immunol."},{"key":"810_CR21","doi-asserted-by":"publisher","first-page":"404","DOI":"10.3389\/fonc.2018.00404","volume":"8","author":"J Jia","year":"2018","unstructured":"Jia, J. et al. Interactions between nanoparticles and dendritic cells: from the perspective of cancer immunotherapy. Front. Oncol. 8, 404\u2013404 (2018).","journal-title":"Front. Oncol."},{"key":"810_CR22","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1007\/s00705-018-3856-0","volume":"163","author":"FB Sulczewski","year":"2018","unstructured":"Sulczewski, F. B., Liszbinski, R. B., Romao, P. R. T. & Rodrigues Junior, L. C. Nanoparticle vaccines against viral infections. Arch. Virol. 163, 2313\u20132325 (2018).","journal-title":"Arch. Virol."},{"key":"810_CR23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fimmu.2019.00022","volume":"10","author":"S Al-Halifa","year":"2019","unstructured":"Al-Halifa, S., Gauthier, L., Arpin, D., Bourgault, S. & Archambault, D. Nanoparticle-based vaccines against respiratory viruses. Front. Immunol. 10, 22 (2019).","journal-title":"Front. Immunol."},{"key":"810_CR24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/cmi.2015.74","volume":"13","author":"Q Liu","year":"2016","unstructured":"Liu, Q., Zhou, Y. H. & Yang, Z. Q. The cytokine storm of severe influenza and development of immunomodulatory therapy. Cell. Mol. Immunol. 13, 3\u201310 (2016).","journal-title":"Cell. Mol. Immunol."},{"key":"810_CR25","doi-asserted-by":"publisher","first-page":"102506","DOI":"10.1016\/j.jaut.2020.102506","volume":"114","author":"Y Rodriguez","year":"2016","unstructured":"Rodriguez, Y. et al. Autoinflammatory and autoimmune conditions at the crossroad of COVID-19. J. Autoimmun. 114, 102506 (2016).","journal-title":"J. Autoimmun."},{"key":"810_CR26","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.it.2015.05.007","volume":"36","author":"DR Getts","year":"2015","unstructured":"Getts, D. R., Shea, L. D., Miller, S. D. & King, N. J. C. Harnessing nanoparticles for immune modulation. Trends Immunol. 36, 419\u2013427 (2015).","journal-title":"Trends Immunol."},{"key":"810_CR27","doi-asserted-by":"publisher","first-page":"e1452","DOI":"10.1002\/wnan.1452","volume":"9","author":"LI Selby","year":"2017","unstructured":"Selby, L. I., Cortez-Jugo, C. M., Such, G. K. & Johnston, A. P. R. Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 9, e1452 (2017).","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"810_CR28","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1021\/acs.bioconjchem.8b00732","volume":"30","author":"SA Smith","year":"2019","unstructured":"Smith, S. A., Selby, L. I., Johnston, A. P. R. & Such, G. K. The endosomal escape of nanoparticles: toward more efficient cellular delivery. Bioconjug. Chem. 30, 263\u2013272 (2019).","journal-title":"Bioconjug. Chem."},{"key":"810_CR29","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1211\/jpp.58.6.0003","volume":"58","author":"KL White","year":"2006","unstructured":"White, K. L., Rades, T., Furneaux, R. H., Tyler, P. C. & Hook, S. Mannosylated liposomes as antigen delivery vehicles for targeting to dendritic cells. J. Pharm. Pharmacol. 58, 729\u2013737 (2006).","journal-title":"J. Pharm. Pharmacol."},{"key":"810_CR30","doi-asserted-by":"publisher","first-page":"e0127057","DOI":"10.1371\/journal.pone.0127057","volume":"10","author":"I Pujol-Autonell","year":"2015","unstructured":"Pujol-Autonell, I. et al. Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes. PLoS One 10, e0127057 (2015).","journal-title":"PLoS One"},{"key":"810_CR31","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jconrel.2011.08.009","volume":"156","author":"KY Dane","year":"2011","unstructured":"Dane, K. Y. et al. Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival. J. Control. Release 156, 154\u2013160 (2011).","journal-title":"J. Control. Release"},{"key":"810_CR32","doi-asserted-by":"publisher","first-page":"E156","DOI":"10.1073\/pnas.1408686111","volume":"112","author":"RA Maldonado","year":"2015","unstructured":"Maldonado, R. A. et al. Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance. Proc. Natl Acad. Sci. USA 112, E156 (2015).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"810_CR33","doi-asserted-by":"publisher","first-page":"1800335","DOI":"10.1002\/adhm.201800335","volume":"7","author":"C Fornaguera","year":"2018","unstructured":"Fornaguera, C. et al. mRNA delivery system for targeting antigen-presenting cells in vivo. Adv. Healthc. Mater. 7, 1800335 (2018).","journal-title":"Adv. Healthc. Mater."},{"key":"810_CR34","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.nano.2014.11.004","volume":"11","author":"K Fytianos","year":"2015","unstructured":"Fytianos, K. et al. Uptake efficiency of surface modified gold nanoparticles does not correlate with functional changes and cytokine secretion in human dendritic cells in vitro. Nanomedicine 11, 633\u2013644 (2015).","journal-title":"Nanomedicine"},{"key":"810_CR35","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1021\/bc500467u","volume":"25","author":"D Arosio","year":"2014","unstructured":"Arosio, D. et al. Effective targeting of DC-SIGN by \u03b1-fucosylamide functionalized gold nanoparticles. Bioconjug. Chem. 25, 2244\u20132251 (2014).","journal-title":"Bioconjug. Chem."},{"key":"810_CR36","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.biomaterials.2017.11.017","volume":"155","author":"SO Stead","year":"2018","unstructured":"Stead, S. O. et al. Manipulating human dendritic cell phenotype and function with targeted porous silicon nanoparticles. Biomaterials 155, 92\u2013102 (2018).","journal-title":"Biomaterials"},{"key":"810_CR37","doi-asserted-by":"publisher","first-page":"6637","DOI":"10.1021\/acsnano.8b01625","volume":"12","author":"SO Stead","year":"2018","unstructured":"Stead, S. O. et al. Murine and non-human primate dendritic cell targeting nanoparticles for in vivo generation of regulatory T-Cells. ACS Nano 12, 6637\u20136647 (2018).","journal-title":"ACS Nano"},{"key":"810_CR38","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.molimm.2017.12.022","volume":"98","author":"D Urbanavicius","year":"2018","unstructured":"Urbanavicius, D., Alvarez, T., Such, G. K., Johnston, A. P. R. & Mintern, J. D. The potential of nanoparticle vaccines as a treatment for cancer. Mol. Immunol. 98, 2\u20137 (2018).","journal-title":"Mol. Immunol."},{"key":"810_CR39","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jconrel.2019.02.025","volume":"300","author":"E Saito","year":"2019","unstructured":"Saito, E. et al. Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation. J. Control. Release 300, 185\u2013196 (2019).","journal-title":"J. Control. Release"},{"key":"810_CR40","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1021\/acsbiomaterials.7b00831","volume":"4","author":"RP Allen","year":"2018","unstructured":"Allen, R. P., Bolandparvaz, A., Ma, J. A., Manickam, V. A. & Lewis, J. S. Latent, immunosuppressive nature of poly(lactic-co-glycolic acid) microparticles. ACS Biomater. Sci. Eng. 4, 900\u2013918 (2018).","journal-title":"ACS Biomater. Sci. Eng."},{"key":"810_CR41","doi-asserted-by":"publisher","first-page":"3926","DOI":"10.1021\/nn3057005","volume":"7","author":"K Niikura","year":"2013","unstructured":"Niikura, K. et al. Gold nanoparticles as a vaccine platform: influence of size and shape on immunological responses in vitro and in vivo. ACS Nano 7, 3926\u20133938 (2013).","journal-title":"ACS Nano"},{"key":"810_CR42","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.apmt.2018.12.006","volume":"15","author":"X Sun","year":"2019","unstructured":"Sun, X. et al. Tracking stem cells and macrophages with gold and iron oxide nanoparticles \u2013 the choice of the best suited particles. Appl. Mater. Today 15, 267\u2013279 (2019).","journal-title":"Appl. Mater. Today"},{"key":"810_CR43","doi-asserted-by":"publisher","first-page":"1800095","DOI":"10.1002\/adtp.201800095","volume":"2","author":"T Tieu","year":"2019","unstructured":"Tieu, T., Alba, M., Elnathan, R., Cifuentes-Rius, A. & Voelcker, N. H. Advances in porous silicon\u2013based nanomaterials for diagnostic and therapeutic applications. Adv. Ther. 2, 1800095 (2019).","journal-title":"Adv. Ther."},{"key":"810_CR44","doi-asserted-by":"publisher","first-page":"1902952","DOI":"10.1002\/adma.201902952","volume":"31","author":"B Kim","year":"2019","unstructured":"Kim, B. et al. Securing the payload, finding the cell, and avoiding the endosome: peptide-targeted, fusogenic porous silicon nanoparticles for delivery of siRNA. Adv. Mater. 31, 1902952 (2019).","journal-title":"Adv. Mater."},{"key":"810_CR45","doi-asserted-by":"publisher","first-page":"4218","DOI":"10.1039\/C6CS00636A","volume":"46","author":"S Behzadi","year":"2017","unstructured":"Behzadi, S. et al. Cellular uptake of nanoparticles: journey inside the cell. Chem. Soc. Rev. 46, 4218\u20134244 (2017).","journal-title":"Chem. Soc. Rev."},{"key":"810_CR46","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1002\/eji.200737984","volume":"38","author":"V Manolova","year":"2008","unstructured":"Manolova, V. et al. Nanoparticles target distinct dendritic cell populations according to their size. Eur. J. Immunol. 38, 1404\u20131413 (2008).","journal-title":"Eur. J. Immunol."},{"key":"810_CR47","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.biomaterials.2017.03.047","volume":"132","author":"M Rincon-Restrepo","year":"2017","unstructured":"Rincon-Restrepo, M. et al. Vaccine nanocarriers: Coupling intracellular pathways and cellular biodistribution to control CD4 vs CD8 T cell responses. Biomaterials 132, 48\u201358 (2017).","journal-title":"Biomaterials"},{"key":"810_CR48","doi-asserted-by":"publisher","first-page":"8894","DOI":"10.1016\/j.actbio.2013.06.010","volume":"9","author":"F Shima","year":"2013","unstructured":"Shima, F., Uto, T., Akagi, T., Baba, M. & Akashi, M. Size effect of amphiphilic poly(gamma-glutamic acid) nanoparticles on cellular uptake and maturation of dendritic cells in vivo. Acta Biomater. 9, 8894\u20138901 (2013).","journal-title":"Acta Biomater."},{"key":"810_CR49","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.clim.2015.03.004","volume":"160","author":"C Engman","year":"2015","unstructured":"Engman, C. et al. Generation of antigen-specific Foxp3+ regulatory T-cells in vivo following administration of diabetes-reversing tolerogenic microspheres does not require provision of antigen in the formulation. Clin. Immunol. 160, 103\u2013123 (2015).","journal-title":"Clin. Immunol."},{"key":"810_CR50","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1021\/acsbiomaterials.9b00332","volume":"5","author":"JS Lewis","year":"2019","unstructured":"Lewis, J. S. et al. Dual-sized microparticle system for generating suppressive dendritic cells prevents and reverses type 1 diabetes in the nonobese diabetic mouse model. ACS Biomater. Sci. Eng. 5, 2631\u20132646 (2019).","journal-title":"ACS Biomater. Sci. Eng."},{"key":"810_CR51","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.immuni.2014.12.024","volume":"42","author":"MY Gerner","year":"2015","unstructured":"Gerner, M. Y., Torabi-Parizi, P. & Germain, R. N. Strategically localized dendritic cells promote rapid T cell responses to lymph-borne particulate antigens. Immunity 42, 172\u2013185 (2015).","journal-title":"Immunity"},{"key":"810_CR52","doi-asserted-by":"crossref","unstructured":"Porter, C. J. H. & Trevaskis, N. L. Nat. Nanotechnol. 15, 423\u2013425 (2020).","DOI":"10.1038\/s41565-020-0663-z"},{"key":"810_CR53","doi-asserted-by":"publisher","unstructured":"Mates, J. M. et al. Mouse liver sinusoidal endothelium eliminates HIV-like particles from blood at a rate of 100 million per minute by a second-order kinetic process. Front. Immunol. https:\/\/doi.org\/10.3389\/fimmu.2017.00035 (2017).","DOI":"10.3389\/fimmu.2017.00035"},{"key":"810_CR54","doi-asserted-by":"publisher","first-page":"5229","DOI":"10.2147\/IJN.S210546","volume":"14","author":"SH Kim","year":"2019","unstructured":"Kim, S. H. et al. Induction of antigen-specific immune tolerance using biodegradable nanoparticles containing antigen and dexamethasone. Int. J. Nanomedicine 14, 5229\u20135242 (2019).","journal-title":"Int. J. Nanomedicine"},{"key":"810_CR55","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1016\/j.ymthe.2017.03.032","volume":"25","author":"R Kuo","year":"2017","unstructured":"Kuo, R., Saito, E., Miller, S. D. & Shea, L. D. Peptide-conjugated nanoparticles reduce positive co-stimulatory expression and T cell activity to induce tolerance. Mol. Ther. 25, 1676\u20131685 (2017).","journal-title":"Mol. Ther."},{"key":"810_CR56","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1021\/nn405033r","volume":"8","author":"Z Hunter","year":"2014","unstructured":"Hunter, Z. et al. A biodegradable nanoparticle platform for the induction of antigen-specific immune tolerance for treatment of autoimmune disease. ACS Nano 8, 2148\u20132160 (2014).","journal-title":"ACS Nano"},{"key":"810_CR57","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jconrel.2015.09.069","volume":"220","author":"S Kumar","year":"2015","unstructured":"Kumar, S., Anselmo, A. C., Banerjee, A., Zakrewsky, M. & Mitragotri, S. Shape and size-dependent immune response to antigen-carrying nanoparticles. J. Control. Release 220, 141\u2013148 (2015).","journal-title":"J. Control. Release"},{"key":"810_CR58","doi-asserted-by":"publisher","first-page":"10066","DOI":"10.1021\/nn404166q","volume":"7","author":"A Cifuentes-Rius","year":"2013","unstructured":"Cifuentes-Rius, A., de Puig, H., Kah, J. C. Y., Borros, S. & Hamad-Schifferli, K. Optimizing the properties of the protein corona surrounding nanoparticles for tuning payload release. ACS Nano 7, 10066\u201310074 (2013).","journal-title":"ACS Nano"},{"key":"810_CR59","doi-asserted-by":"publisher","first-page":"1701956","DOI":"10.1002\/adfm.201701956","volume":"27","author":"BD Johnston","year":"2017","unstructured":"Johnston, B. D. et al. Colloidal stability and surface chemistry are key factors for the composition of the protein corona of inorganic gold nanoparticles. Adv. Funct. Mater. 27, 1701956 (2017).","journal-title":"Adv. Funct. Mater."},{"key":"810_CR60","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jconrel.2008.05.005","volume":"130","author":"W Yan","year":"2008","unstructured":"Yan, W., Chen, W. & Huang, L. Reactive oxygen species play a central role in the activity of cationic liposome based cancer vaccine. J. Control. Release 130, 22\u201328 (2008).","journal-title":"J. Control. Release"},{"key":"810_CR61","doi-asserted-by":"publisher","first-page":"219ra217","DOI":"10.1126\/scitranslmed.3007563","volume":"6","author":"DR Getts","year":"2014","unstructured":"Getts, D. R. et al. Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Sci. Transl. Med. 6, 219ra217 (2014).","journal-title":"Sci. Transl. Med."},{"key":"810_CR62","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jconrel.2017.05.014","volume":"258","author":"E Zupancic","year":"2017","unstructured":"Zupancic, E. et al. Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming. J. Control. Release 258, 182\u2013195 (2017).","journal-title":"J. Control. Release"},{"key":"810_CR63","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1126\/science.8248784","volume":"262","author":"MF Bachmann","year":"1993","unstructured":"Bachmann, M. F. et al. The influence of antigen organization on B cell responsiveness. Science 262, 1448\u20131451 (1993).","journal-title":"Science"},{"key":"810_CR64","doi-asserted-by":"publisher","first-page":"6791","DOI":"10.1016\/j.biomaterials.2011.04.082","volume":"32","author":"LJ Cruz","year":"2011","unstructured":"Cruz, L. J., Tacken, P. J., Fokkink, R. & Figdor, C. G. The influence of PEG chain length and targeting moiety on antibody-mediated delivery of nanoparticle vaccines to human dendritic cells. Biomaterials 32, 6791\u20136803 (2011).","journal-title":"Biomaterials"},{"key":"810_CR65","doi-asserted-by":"publisher","first-page":"119791","DOI":"10.1016\/j.biomaterials.2020.119791","volume":"240","author":"M Landgraf","year":"2020","unstructured":"Landgraf, M. et al. Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis. Biomaterials 240, 119791 (2020).","journal-title":"Biomaterials"},{"key":"810_CR66","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1021\/acs.nanolett.8b04916","volume":"19","author":"KW Yong","year":"2019","unstructured":"Yong, K. W., Yuen, D., Chen, M. Z., Porter, C. J. H. & Johnston, A. P. R. Pointing in the right direction: controlling the orientation of proteins on nanoparticles improves targeting efficiency. Nano Letters 19, 1827\u20131831 (2019).","journal-title":"Nano Letters"},{"key":"810_CR67","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41577-018-0088-1","volume":"19","author":"SC Eisenbarth","year":"2019","unstructured":"Eisenbarth, S. C. Dendritic cell subsets in T cell programming: location dictates function. Nat. Rev. Immunol. 19, 89\u2013103 (2019).","journal-title":"Nat. Rev. Immunol."},{"key":"810_CR68","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4939-3606-9_1","volume":"1423","author":"E Segura","year":"2016","unstructured":"Segura, E. Review of mouse and human dendritic cell subsets. Methods Mol. Biol. 1423, 3\u201315 (2016).","journal-title":"Methods Mol. Biol."},{"key":"810_CR69","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1002\/adhm.201200441","volume":"2","author":"JD Mintern","year":"2013","unstructured":"Mintern, J. D. et al. Targeting dendritic cells: the role of specific receptors in the internalization of polymer capsules. Adv. Healthc. Mater. 2, 940\u2013944 (2013).","journal-title":"Adv. Healthc. Mater."},{"key":"810_CR70","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1002\/eji.201040419","volume":"40","author":"OP Joffre","year":"2010","unstructured":"Joffre, O. P., Sancho, D., Zelenay, S. & Keller, A. M. & Reis e Sousa, C. Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1\/CLEC9A. Eur. J. Immunol. 40, 1255\u20131265 (2010).","journal-title":"Eur. J. Immunol."},{"key":"810_CR71","doi-asserted-by":"publisher","first-page":"3264","DOI":"10.1182\/blood-2008-05-155176","volume":"112","author":"I Caminschi","year":"2008","unstructured":"Caminschi, I. et al. The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement. Blood 112, 3264\u20133273 (2008).","journal-title":"Blood"},{"key":"810_CR72","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1900\/RDS.2012.9.305","volume":"9","author":"C Petzold","year":"2012","unstructured":"Petzold, C., Schallenberg, S., Stern, J. N. H. & Kretschmer, K. Targeted antigen delivery to DEC-205+ dendritic cells for tolerogenic vaccination. Rev. Diabet. Stud. 9, 305\u2013318 (2012).","journal-title":"Rev. Diabet. Stud."},{"key":"810_CR73","doi-asserted-by":"publisher","unstructured":"Schetters, S. T. T. et al. Mouse DC-SIGN\/CD209a as target for antigen delivery and adaptive immunity. Front. Immunol. https:\/\/doi.org\/10.3389\/fimmu.2018.00990 (2018).","DOI":"10.3389\/fimmu.2018.00990"},{"key":"810_CR74","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/nri3712","volume":"14","author":"M Guilliams","year":"2014","unstructured":"Guilliams, M. et al. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat. Rev. Immunol. 14, 571\u2013578 (2014).","journal-title":"Nat. Rev. Immunol."},{"key":"810_CR75","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.clim.2015.03.013","volume":"160","author":"KA Hlavaty","year":"2015","unstructured":"Hlavaty, K. A., Luo, X., Shea, L. D. & Miller, S. D. Cellular and molecular targeting for nanotherapeutics in transplantation tolerance. Clin. Immunol. 160, 14\u201323 (2015).","journal-title":"Clin. Immunol."},{"key":"810_CR76","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/nnano.2016.135","volume":"11","author":"TK Kishimoto","year":"2016","unstructured":"Kishimoto, T. K. et al. Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles. Nat. Nanotechnol. 11, 890\u2013899 (2016).","journal-title":"Nat. Nanotechnol."},{"key":"810_CR77","doi-asserted-by":"publisher","first-page":"6457","DOI":"10.4049\/jimmunol.0901717","volume":"184","author":"X Zheng","year":"2010","unstructured":"Zheng, X. et al. Treatment of autoimmune arthritis using RNA interference-modulated dendritic cells. J. Immunol. 184, 6457 (2010).","journal-title":"J. Immunol."},{"key":"810_CR78","doi-asserted-by":"publisher","first-page":"11270","DOI":"10.1073\/pnas.1120611109","volume":"109","author":"A Yeste","year":"2012","unstructured":"Yeste, A., Nadeau, M., Burns, E. J., Weiner, H. L. & Quintana, F. J. Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc. Natl Acad. Sci. USA 109, 11270\u201311275 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"810_CR79","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.molmed.2011.11.002","volume":"18","author":"SM Metcalfe","year":"2012","unstructured":"Metcalfe, S. M. & Fahmy, T. M. Targeted nanotherapy for induction of therapeutic immune responses. Trends Mol. Med. 18, 72\u201380 (2012).","journal-title":"Trends Mol. Med."},{"key":"810_CR80","unstructured":"Wood, K. J., Shankar, S., Hester, J. & Issa, F. Clinical Immunology 5th Edition (Elsevier, 2019)."},{"key":"810_CR81","doi-asserted-by":"publisher","unstructured":"Page, E., Dar, W. & Knechtle, S. Tolerogenic therapies in transplantation. Front. Immunol. https:\/\/doi.org\/10.3389\/fimmu.2012.00198 (2012).","DOI":"10.3389\/fimmu.2012.00198"},{"key":"810_CR82","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12623","volume":"7","author":"Q Zhuang","year":"2016","unstructured":"Zhuang, Q. et al. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat. Commun. 7, 12623 (2016).","journal-title":"Nat. Commun."},{"key":"810_CR83","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0022-4804(03)00081-7","volume":"111","author":"RA Schroeder","year":"2003","unstructured":"Schroeder, R. A., Marroquin, C. E. & Kuo, P. C. Tolerance and the \"Holy Grail\" of transplantation. J. Surg. Res. 111, 109\u2013119 (2003).","journal-title":"J. Surg. Res."},{"key":"810_CR84","doi-asserted-by":"publisher","first-page":"8887","DOI":"10.1016\/j.biomaterials.2014.06.044","volume":"35","author":"J Bryant","year":"2014","unstructured":"Bryant, J. et al. Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation. Biomaterials 35, 8887\u20138894 (2014).","journal-title":"Biomaterials"},{"key":"810_CR85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.10.041","volume":"76","author":"KA Hlavaty","year":"2016","unstructured":"Hlavaty, K. A. et al. Tolerance induction using nanoparticles bearing HY peptides in bone marrow transplantation. Biomaterials 76, 1\u201310 (2016).","journal-title":"Biomaterials"},{"key":"810_CR86","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3389\/fimmu.2015.00288","volume":"6","author":"JD Price","year":"2015","unstructured":"Price, J. D. & Tarbell, K. V. The role of dendritic cell subsets and innate immunity in the pathogenesis of type 1 diabetes and other autoimmune diseases. Front. Immunol. 6, 288 (2015).","journal-title":"Front. Immunol."},{"key":"810_CR87","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3389\/fmed.2018.00202","volume":"5","author":"R Bottino","year":"2018","unstructured":"Bottino, R., Knoll, M. F., Knoll, C. A., Bertera, S. & Trucco, M. M. The future of islet transplantation is now. Front. Med. 5, 202 (2018).","journal-title":"Front. Med."},{"key":"810_CR88","doi-asserted-by":"publisher","first-page":"6357","DOI":"10.4049\/jimmunol.1101638","volume":"187","author":"FS Kleijwegt","year":"2011","unstructured":"Kleijwegt, F. S. et al. Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells. J. Immunol. 187, 6357\u20136364 (2011).","journal-title":"J. Immunol."},{"key":"810_CR89","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/sji.12039","volume":"77","author":"R Volchenkov","year":"2013","unstructured":"Volchenkov, R., Karlsen, M., Jonsson, R. & Appel, S. Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells. Scand. J. Immunol. 77, 246\u2013254 (2013).","journal-title":"Scand. J. Immunol."},{"key":"810_CR90","doi-asserted-by":"publisher","first-page":"6374","DOI":"10.1073\/pnas.0802644105","volume":"105","author":"A Mukhopadhaya","year":"2008","unstructured":"Mukhopadhaya, A. et al. Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice. Proc. Natl Acad. Sci. USA 105, 6374\u20136379 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"810_CR91","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.2337\/db14-1880","volume":"64","author":"JD Price","year":"2015","unstructured":"Price, J. D., Hotta-Iwamura, C., Zhao, Y., Beauchamp, N. M. & Tarbell, K. V. DCIR2+ cDC2 DCs and Zbtb32 restore CD4+ T-Cell tolerance and inhibit diabetes. Diabetes 64, 3521\u20133531 (2015).","journal-title":"Diabetes"},{"key":"810_CR92","doi-asserted-by":"publisher","first-page":"ra61","DOI":"10.1126\/scisignal.aad0612","volume":"9","author":"A Yeste","year":"2016","unstructured":"Yeste, A. et al. Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2. Sci. Signal. 9, ra61 (2016).","journal-title":"Sci. Signal."},{"key":"810_CR93","doi-asserted-by":"publisher","first-page":"513295","DOI":"10.1155\/2015\/513295","volume":"2015","author":"ZX Xie","year":"2015","unstructured":"Xie, Z. X. et al. Role of the immunogenic and tolerogenic subsets of dendritic cells in multiple sclerosis. Mediators Inflamm. 2015, 513295 (2015).","journal-title":"Mediators Inflamm."},{"key":"810_CR94","first-page":"5314541","volume":"2016","author":"GR Dos Passos","year":"2016","unstructured":"Dos Passos, G. R., Sato, D. K., Becker, J. & Fujihara, K. Th17 cells pathways in multiple sclerosis and neuromyelitis optica spectrum disorders: pathophysiological and therapeutic implications. Mediators Inflamm. 2016, 5314541 (2016).","journal-title":"Mediators Inflamm."},{"key":"810_CR95","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1002\/eji.201546274","volume":"46","author":"L Wang","year":"2016","unstructured":"Wang, L., Li, Z., Ciric, B., Safavi, F., Zhang, G. X. & Rostami, A. Selective depletion of CD11c. Eur. J. Immunol. 46, 2454\u20132466 (2016).","journal-title":"Eur. J. Immunol."},{"key":"810_CR96","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.3389\/fimmu.2018.01169","volume":"9","author":"G Fl\u00f3rez-Grau","year":"2018","unstructured":"Fl\u00f3rez-Grau, G., Zubizarreta, I., Cabez\u00f3n, R., Villoslada, P. & Benitez-Ribas, D. Tolerogenic dendritic cells as a promising antigen-specific therapy in the treatment of multiple sclerosis and neuromyelitis optica from preclinical to clinical trials. Front. Immunol. 9, 1169 (2018).","journal-title":"Front. Immunol."},{"key":"810_CR97","doi-asserted-by":"publisher","first-page":"5681","DOI":"10.1016\/j.vaccine.2014.08.016","volume":"32","author":"G Cappellano","year":"2014","unstructured":"Cappellano, G. et al. Subcutaneous inverse vaccination with PLGA particles loaded with a MOG peptide and IL-10 decreases the severity of experimental autoimmune encephalomyelitis. Vaccine 32, 5681\u20135689 (2014).","journal-title":"Vaccine"},{"key":"810_CR98","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1038\/nbt.2434","volume":"30","author":"DR Getts","year":"2012","unstructured":"Getts, D. R. et al. Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis. Nat. Biotechnol. 30, 1217\u20131224 (2012).","journal-title":"Nat. Biotechnol."},{"key":"810_CR99","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.4049\/jimmunol.1001322","volume":"186","author":"TL Papenfuss","year":"2011","unstructured":"Papenfuss, T. L. et al. Estriol generates tolerogenic dendritic cells in vivo that protect against autoimmunity. J. Immunol. 186, 3346\u20133355 (2011).","journal-title":"J. Immunol."},{"key":"810_CR100","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3389\/fimmu.2018.00281","volume":"9","author":"RA LaMothe","year":"2018","unstructured":"LaMothe, R. A. et al. Tolerogenic nanoparticles induce antigen-specific regulatory T cells and provide therapeutic efficacy and transferrable tolerance against experimental autoimmune encephalomyelitis. Front. Immunol. 9, 281 (2018).","journal-title":"Front. Immunol."},{"key":"810_CR101","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","volume":"164","author":"CS Constantinescu","year":"2011","unstructured":"Constantinescu, C. S., Farooqi, N., O\u2019Brien, K. & Gran, B. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). Br. J. Pharmacol. 164, 1079\u20131106 (2011).","journal-title":"Br. J. Pharmacol."},{"key":"810_CR102","doi-asserted-by":"publisher","first-page":"17280","DOI":"10.1073\/pnas.1010263107","volume":"107","author":"JN Stern","year":"2010","unstructured":"Stern, J. N. et al. Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells. Proc. Natl Acad. Sci. USA 107, 17280\u201317285 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"810_CR103","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s10020-018-0017-6","volume":"24","author":"I Tabansky","year":"2018","unstructured":"Tabansky, I. et al. Targeting DEC-205(-)DCIR2(+) dendritic cells promotes immunological tolerance in proteolipid protein-induced experimental autoimmune encephalomyelitis. Mol. Med. 24, 17 (2018).","journal-title":"Mol. Med."},{"key":"810_CR104","doi-asserted-by":"publisher","first-page":"6346","DOI":"10.4049\/jimmunol.1102307","volume":"187","author":"J Loschko","year":"2011","unstructured":"Loschko, J. et al. Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity. J. Immunol. 187, 6346\u20136356 (2011).","journal-title":"J. Immunol."},{"key":"810_CR105","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.immuni.2019.01.020","volume":"50","author":"JB Wing","year":"2019","unstructured":"Wing, J. B., Tanaka, A. & Sakaguchi, S. Human FOXP3(+) regulatory T Cell heterogeneity and function in autoimmunity and cancer. Immunity 50, 302\u2013316 (2019).","journal-title":"Immunity"}],"container-title":["Nature Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41565-020-00810-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41565-020-00810-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41565-020-00810-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T18:37:09Z","timestamp":1733942229000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41565-020-00810-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,21]]},"references-count":105,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["810"],"URL":"https:\/\/doi.org\/10.1038\/s41565-020-00810-2","relation":{},"ISSN":["1748-3387","1748-3395"],"issn-type":[{"value":"1748-3387","type":"print"},{"value":"1748-3395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,21]]},"assertion":[{"value":"5 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}