{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:31:13Z","timestamp":1793071873896,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat. Nanotechnol."],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1038\/s41565-024-01759-2","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T10:03:01Z","timestamp":1724061781000},"page":"1745-1756","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Synthetic polypeptides inhibit nucleic acid-induced inflammation in autoimmune diseases by disrupting multivalent TLR9 binding to LL37-DNA bundles"],"prefix":"10.1038","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5431-1185","authenticated-orcid":false,"given":"Xingliang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5590-4849","authenticated-orcid":false,"given":"Zhi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7822-8716","authenticated-orcid":false,"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-4977","authenticated-orcid":false,"given":"Lixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2843-5543","authenticated-orcid":false,"given":"Yongming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"1759_CR1","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1056\/NEJM200108023450506","volume":"345","author":"A Davidson","year":"2001","unstructured":"Davidson, A. & Diamond, B. Autoimmune diseases. N. Engl. J. Med. 345, 340\u2013350 (2001).","journal-title":"N. Engl. J. Med."},{"key":"1759_CR2","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1126\/science.1099896","volume":"305","author":"L Steinman","year":"2004","unstructured":"Steinman, L. Immune therapy for autoimmune diseases. Science 305, 212\u2013216 (2004).","journal-title":"Science"},{"key":"1759_CR3","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nrrheum.2012.66","volume":"8","author":"HT Maecker","year":"2012","unstructured":"Maecker, H. T. et al. New tools for classification and monitoring of autoimmune diseases. Nat. Rev. Rheumatol. 8, 317\u2013328 (2012).","journal-title":"Nat. Rev. Rheumatol."},{"key":"1759_CR4","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0140-6736(13)60954-X","volume":"382","author":"M Wahren-Herlenius","year":"2013","unstructured":"Wahren-Herlenius, M. & D\u00f6rner, T. Immunopathogenic mechanisms of systemic autoimmune disease. Lancet 382, 819\u2013831 (2013).","journal-title":"Lancet"},{"key":"1759_CR5","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41578-022-00426-z","volume":"7","author":"Z Tu","year":"2022","unstructured":"Tu, Z. et al. Design of therapeutic biomaterials to control inflammation. Nat. Rev. Mater. 7, 557\u2013574 (2022).","journal-title":"Nat. Rev. Mater."},{"key":"1759_CR6","doi-asserted-by":"publisher","first-page":"e40862","DOI":"10.1371\/journal.pone.0040862","volume":"7","author":"NA Stearns","year":"2012","unstructured":"Stearns, N. A., Lee, J., Leong, K. W., Sullenger, B. A. & Pisetsky, D. S. The inhibition of anti-DNA binding to DNA by nucleic acid binding polymers. PLoS ONE 7, e40862 (2012).","journal-title":"PLoS ONE"},{"key":"1759_CR7","doi-asserted-by":"publisher","first-page":"12938","DOI":"10.1073\/pnas.1204928109","volume":"109","author":"S Jain","year":"2012","unstructured":"Jain, S. et al. Nucleic acid scavengers inhibit thrombosis without increasing bleeding. Proc. Natl Acad. Sci. USA 109, 12938\u201312943 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1759_CR8","doi-asserted-by":"publisher","first-page":"420e","DOI":"10.1097\/PRS.0000000000000471","volume":"134","author":"EK Holl","year":"2014","unstructured":"Holl, E. K. et al. The nucleic acid scavenger polyamidoamine third-generation dendrimer inhibits fibroblast activation and granulation tissue contraction. Plast. Reconstr. Surg. 134, 420e\u2013433e (2014).","journal-title":"Plast. Reconstr. Surg."},{"key":"1759_CR9","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1021\/acs.nanolett.0c04759","volume":"21","author":"F Liu","year":"2021","unstructured":"Liu, F. et al. A cationic metal-organic framework to scavenge cell-free DNA for severe sepsis management. Nano Lett. 21, 2461\u20132469 (2021).","journal-title":"Nano Lett."},{"key":"1759_CR10","doi-asserted-by":"publisher","first-page":"3677","DOI":"10.1016\/j.matt.2021.09.001","volume":"4","author":"F Liu","year":"2021","unstructured":"Liu, F. et al. Targeting multiple mediators of sepsis using multifunctional tannic acid-Zn2+-gentamicin nanoparticles. Matter 4, 3677\u20133695 (2021).","journal-title":"Matter"},{"key":"1759_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33492-6","volume":"13","author":"H Huang","year":"2022","unstructured":"Huang, H. et al. Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis. Nat. Commun. 13, 5925 (2022).","journal-title":"Nat. Commun."},{"key":"1759_CR12","doi-asserted-by":"publisher","first-page":"eabj2372","DOI":"10.1126\/sciadv.abj2372","volume":"8","author":"C Shi","year":"2022","unstructured":"Shi, C. et al. A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease. Sci. Adv. 8, eabj2372 (2022).","journal-title":"Sci. Adv."},{"key":"1759_CR13","doi-asserted-by":"publisher","first-page":"2206789","DOI":"10.1002\/advs.202206789","volume":"10","author":"M Sun","year":"2023","unstructured":"Sun, M. et al. Circulating cell-free DNAs as a biomarker and therapeutic target for acetaminophen-induced liver injury. Adv. Sci. 10, 2206789 (2023).","journal-title":"Adv. Sci."},{"key":"1759_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06603-5","volume":"9","author":"H Liang","year":"2018","unstructured":"Liang, H. et al. Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation. Nat. Commun. 9, 4291 (2018).","journal-title":"Nat. Commun."},{"key":"1759_CR15","doi-asserted-by":"publisher","first-page":"4254","DOI":"10.1002\/anie.201813362","volume":"58","author":"B Peng","year":"2019","unstructured":"Peng, B. et al. Tuned cationic dendronized polymer: molecular scavenger for rheumatoid arthritis treatment. Angew. Chem. Int. Ed. 58, 4254\u20134258 (2019).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1759_CR16","doi-asserted-by":"publisher","first-page":"2000391","DOI":"10.1002\/adfm.202000391","volume":"30","author":"J Wu","year":"2020","unstructured":"Wu, J. et al. Cationic block copolymer nanoparticles with tunable DNA affinity for treating rheumatoid arthritis. Adv. Funct. Mater. 30, 2000391 (2020).","journal-title":"Adv. Funct. Mater."},{"key":"1759_CR17","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/ni1457","volume":"8","author":"J Tian","year":"2007","unstructured":"Tian, J. et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol. 8, 487\u2013496 (2007).","journal-title":"Nat. Immunol."},{"key":"1759_CR18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature08512","volume":"462","author":"H Yanai","year":"2009","unstructured":"Yanai, H. et al. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses. Nature 462, 99\u2013103 (2009).","journal-title":"Nature"},{"key":"1759_CR19","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/emboj.2011.441","volume":"31","author":"Y Li","year":"2012","unstructured":"Li, Y., Berke, I. C. & Modis, Y. DNA binding to proteolytically activated TLR9 is sequence\u2010independent and enhanced by DNA curvature. EMBO J. 31, 919\u2013931 (2012).","journal-title":"EMBO J."},{"key":"1759_CR20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.cellimm.2014.08.002","volume":"292","author":"S Tug","year":"2014","unstructured":"Tug, S. et al. Correlation between cell free DNA levels and medical evaluation of disease progression in systemic lupus erythematosus patients. Cell. Immunol. 292, 32\u201339 (2014).","journal-title":"Cell. Immunol."},{"key":"1759_CR21","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/nmat4298","volume":"14","author":"NW Schmidt","year":"2015","unstructured":"Schmidt, N. W. et al. Liquid-crystalline ordering of antimicrobial peptide-DNA complexes controls TLR9 activation. Nat. Mater. 14, 696\u2013700 (2015).","journal-title":"Nat. Mater."},{"key":"1759_CR22","doi-asserted-by":"publisher","first-page":"9728","DOI":"10.1073\/pnas.1607011113","volume":"113","author":"EK Holl","year":"2016","unstructured":"Holl, E. K. et al. Scavenging nucleic acid debris to combat autoimmunity and infectious disease. Proc. Natl Acad. Sci. USA 113, 9728\u20139733 (2016).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1759_CR23","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/cmi.2017.136","volume":"15","author":"H Lou","year":"2018","unstructured":"Lou, H. & Pickering, M. C. Extracellular DNA and autoimmune diseases. Cell. Mol. Immunol. 15, 746\u2013755 (2018).","journal-title":"Cell. Mol. Immunol."},{"key":"1759_CR24","doi-asserted-by":"publisher","first-page":"502","DOI":"10.3389\/fimmu.2019.00502","volume":"10","author":"B Duvvuri","year":"2019","unstructured":"Duvvuri, B. & Lood, C. Cell-free DNA as a biomarker in autoimmune rheumatic diseases. Front. Immunol. 10, 502 (2019).","journal-title":"Front. Immunol."},{"key":"1759_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09683-z","volume":"10","author":"R Lande","year":"2019","unstructured":"Lande, R. et al. CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-\u03b1 production in systemic sclerosis. Nat. Commun. 10, 1731 (2019).","journal-title":"Nat. Commun."},{"key":"1759_CR26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.semcdb.2018.02.002","volume":"88","author":"EY Lee","year":"2019","unstructured":"Lee, E. Y., Lee, M. W. & Wong, G. C. L. Modulation of Toll-like receptor signaling by antimicrobial peptides. Semin. Cell Dev. Biol. 88, 173\u2013184 (2019).","journal-title":"Semin. Cell Dev. Biol."},{"key":"1759_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13756-4","volume":"11","author":"F Herster","year":"2020","unstructured":"Herster, F. et al. Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis. Nat. Commun. 11, 105 (2020).","journal-title":"Nat. Commun."},{"key":"1759_CR28","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.1093\/rheumatology\/keac722","volume":"62","author":"D Michailidou","year":"2023","unstructured":"Michailidou, D. et al. Immune complex-mediated neutrophil activation in patients with polymyalgia rheumatica. Rheumatology 62, 2880\u20132886 (2023).","journal-title":"Rheumatology"},{"key":"1759_CR29","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.coi.2008.06.008","volume":"20","author":"M Gilliet","year":"2008","unstructured":"Gilliet, M. & Lande, R. Antimicrobial peptides and self-DNA in autoimmune skin inflammation. Curr. Opin. Immunol. 20, 401\u2013407 (2008).","journal-title":"Curr. Opin. Immunol."},{"key":"1759_CR30","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.addr.2004.12.001","volume":"57","author":"H Brooks","year":"2005","unstructured":"Brooks, H., Lebleu, B. & Viv\u00e8s, E. Tat peptide-mediated cellular delivery: back to basics. Adv. Drug Deliv. Rev. 57, 559\u2013577 (2005).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"1759_CR31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.cis.2016.02.003","volume":"232","author":"EY Lee","year":"2016","unstructured":"Lee, E. Y. et al. A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes. Adv. Colloid Interface Sci. 232, 17\u201324 (2016).","journal-title":"Adv. Colloid Interface Sci."},{"key":"1759_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08868-w","volume":"10","author":"EY Lee","year":"2019","unstructured":"Lee, E. Y. et al. Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9. Nat. Commun. 10, 1012 (2019).","journal-title":"Nat. Commun."},{"key":"1759_CR33","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/j.bpj.2023.10.035","volume":"123","author":"C Zielke","year":"2024","unstructured":"Zielke, C., Nielsen, J. E., Lin, J. S. & Barron, A. E. Between good and evil: complexation of the human cathelicidin LL-37 with nucleic acids. Biophys. J. 123, 1316\u20131328 (2024).","journal-title":"Biophys. J."},{"key":"1759_CR34","doi-asserted-by":"publisher","first-page":"e1006315","DOI":"10.1371\/journal.ppat.1006315","volume":"13","author":"SA Tursi","year":"2017","unstructured":"Tursi, S. A. et al. Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9. PLoS Pathog. 13, e1006315 (2017).","journal-title":"PLoS Pathog."},{"key":"1759_CR35","doi-asserted-by":"publisher","first-page":"12145","DOI":"10.1021\/acsnano.7b05234","volume":"11","author":"EY Lee","year":"2017","unstructured":"Lee, E. Y. et al. Crystallinity of double-stranded RNA-antimicrobial peptide complexes modulates Toll-like receptor 3-mediated inflammation. ACS Nano 11, 12145\u201312155 (2017).","journal-title":"ACS Nano"},{"key":"1759_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17736-x","volume":"11","author":"Y Engelberg","year":"2020","unstructured":"Engelberg, Y. & Landau, M. The human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure. Nat. Commun. 11, 3894 (2020).","journal-title":"Nat. Commun."},{"key":"1759_CR37","doi-asserted-by":"publisher","first-page":"11442","DOI":"10.1021\/ja901870d","volume":"131","author":"JS Prell","year":"2009","unstructured":"Prell, J. S., O\u2019Brien, J. T., Steill, J. D., Oomens, J. & Williams, E. R. Structures of protonated dipeptides: the role of arginine in stabilizing salt bridges. J. Am. Chem. Soc. 131, 11442\u201311449 (2009).","journal-title":"J. Am. Chem. Soc."},{"key":"1759_CR38","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1021\/jacsau.1c00193","volume":"1","author":"LT Hao","year":"2021","unstructured":"Hao, L. T. et al. Strong, multifaceted guanidinium-based adhesion of bioorganic nanoparticles to wet biological tissue. JACS Au. 1, 1399\u20131411 (2021).","journal-title":"JACS Au."},{"key":"1759_CR39","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1021\/mp100027g","volume":"7","author":"LE Prevette","year":"2010","unstructured":"Prevette, L. E., Mullen, D. G. & Banaszak Holl, M. M. Polycation-induced cell membrane permeability does not enhance cellular uptake or expression efficiency of delivered DNA. Mol. Pharm. 7, 870\u2013883 (2010).","journal-title":"Mol. Pharm."},{"key":"1759_CR40","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.addr.2018.07.017","volume":"136","author":"A Bernkop-Schn\u00fcrch","year":"2018","unstructured":"Bernkop-Schn\u00fcrch, A. Strategies to overcome the polycation dilemma in drug delivery. Adv. Drug Deliv. Rev. 136\u2013137, 62\u201372 (2018).","journal-title":"Adv. Drug Deliv. Rev."},{"key":"1759_CR41","doi-asserted-by":"publisher","first-page":"6911","DOI":"10.1039\/C5TB01291K","volume":"3","author":"P Guo","year":"2015","unstructured":"Guo, P. et al. Dual functionalized amino poly(glycerol methacrylate) with guanidine and Schiff-base linked imidazole for enhanced gene transfection and minimized cytotoxicity. J. Mater. Chem. B 3, 6911\u20136918 (2015).","journal-title":"J. Mater. Chem. B"},{"key":"1759_CR42","doi-asserted-by":"publisher","first-page":"1903277","DOI":"10.1002\/adma.201903277","volume":"31","author":"M Zheng","year":"2019","unstructured":"Zheng, M. et al. ROS-responsive polymeric siRNA nanomedicine stabilized by triple interactions for the robust glioblastoma combinational RNAi therapy. Adv. Mater. 31, 1903277 (2019).","journal-title":"Adv. Mater."},{"key":"1759_CR43","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nature06116","volume":"449","author":"R Lande","year":"2007","unstructured":"Lande, R. et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449, 564\u2013569 (2007).","journal-title":"Nature"},{"key":"1759_CR44","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1021\/bi2000214","volume":"50","author":"S Park","year":"2011","unstructured":"Park, S. & Lippard, S. J. Redox state-dependent interaction of HMGB1 and cisplatin-modified DNA. Biochemistry 50, 2567\u20132574 (2011).","journal-title":"Biochemistry"},{"key":"1759_CR45","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1140\/epje\/e2005-00003-4","volume":"16","author":"J DeRouchey","year":"2005","unstructured":"DeRouchey, J., Netz, R. R. & R\u00e4dler, J. O. Structural investigations of DNA-polycation complexes. Eur. Phys. J. E 16, 17\u201328 (2005).","journal-title":"Eur. Phys. J. E"},{"key":"1759_CR46","doi-asserted-by":"publisher","first-page":"14055","DOI":"10.1073\/pnas.1105777108","volume":"108","author":"J Lee","year":"2011","unstructured":"Lee, J. et al. Nucleic acid-binding polymers as anti-inflammatory agents. Proc. Natl Acad. Sci. USA 108, 14055\u201314060 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1759_CR47","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/nri1329","volume":"4","author":"DM Klinman","year":"2004","unstructured":"Klinman, D. M. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. 4, 249\u2013259 (2004).","journal-title":"Nat. Rev. Immunol."},{"key":"1759_CR48","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1038\/ni1136","volume":"5","author":"EI Zuniga","year":"2004","unstructured":"Zuniga, E. I., McGavern, D. B., Pruneda-Paz, J. L., Teng, C. & Oldstone, M. B. A. Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection. Nat. Immunol. 5, 1227\u20131234 (2004).","journal-title":"Nat. Immunol."},{"key":"1759_CR49","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1084\/jem.146.3.857","volume":"146","author":"DE Trentham","year":"1977","unstructured":"Trentham, D. E., Townes, A. S. & Kang, A. H. Autoimmunity to type II collagen: an experimental model of arthritis. J. Exp. Med. 146, 857\u2013868 (1977).","journal-title":"J. Exp. Med."},{"key":"1759_CR50","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1021\/nn301215q","volume":"7","author":"S-M Lee","year":"2013","unstructured":"Lee, S.-M. et al. Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles. ACS Nano 7, 50\u201357 (2013).","journal-title":"ACS Nano"},{"key":"1759_CR51","doi-asserted-by":"publisher","first-page":"121594","DOI":"10.1016\/j.biomaterials.2022.121594","volume":"286","author":"X Liu","year":"2022","unstructured":"Liu, X., Chen, S., Yan, Y., Liu, L. & Chen, Y. Nanoparticulate DNA scavenger loading methotrexate targets articular inflammation to enhance rheumatoid arthritis treatment. Biomaterials 286, 121594 (2022).","journal-title":"Biomaterials"}],"container-title":["Nature Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41565-024-01759-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41565-024-01759-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41565-024-01759-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T10:07:03Z","timestamp":1731665223000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41565-024-01759-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["1759"],"URL":"https:\/\/doi.org\/10.1038\/s41565-024-01759-2","relation":{},"ISSN":["1748-3387","1748-3395"],"issn-type":[{"value":"1748-3387","type":"print"},{"value":"1748-3395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,19]]},"assertion":[{"value":"2 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}