{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:58:53Z","timestamp":1793825933805,"version":"4.6.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat. Nanotechnol."],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1038\/s41565-025-01979-0","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T09:03:58Z","timestamp":1754903038000},"page":"1514-1525","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages"],"prefix":"10.1038","volume":"20","author":[{"given":"Haizong","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peidong","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2520-8957","authenticated-orcid":false,"given":"Shengzhe","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feihong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2296-8621","authenticated-orcid":false,"given":"Changgan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9077-6838","authenticated-orcid":false,"given":"Kui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8368-6524","authenticated-orcid":false,"given":"Minggui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-5749","authenticated-orcid":false,"given":"Chengliang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-6792","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2716-5975","authenticated-orcid":false,"given":"Heguang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-4551","authenticated-orcid":false,"given":"Yu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"1979_CR1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jama.2020.20317","volume":"325","author":"MA Mederos","year":"2021","unstructured":"Mederos, M. A., Reber, H. A. & Girgis, M. D. Acute pancreatitis: a review. JAMA 325, 382\u2013390 (2021).","journal-title":"JAMA"},{"key":"1979_CR2","volume":"41","author":"S Jaber","year":"2022","unstructured":"Jaber, S. et al. Guidelines for the management of patients with severe acute pancreatitis, 2021. Anaesth. Crit. Care Pain. Med 41, 101060 (2022).","journal-title":"Anaesth. Crit. Care Pain. Med"},{"key":"1979_CR3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","volume":"62","author":"PA Banks","year":"2013","unstructured":"Banks, P. A. et al. Classification of acute pancreatitis\u20142012: revision of the Atlanta classification and definitions by international consensus. Gut 62, 102\u2013111 (2013).","journal-title":"Gut"},{"key":"1979_CR4","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1074\/jbc.M511276200","volume":"281","author":"OA Mareninova","year":"2006","unstructured":"Mareninova, O. A. et al. Cell death in pancreatitis: caspases protect from necrotizing pancreatitis. J. Biol. Chem. 281, 3370\u20133381 (2006).","journal-title":"J. Biol. Chem."},{"key":"1979_CR5","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jcmgh.2016.04.002","volume":"2","author":"J Louhimo","year":"2016","unstructured":"Louhimo, J., Steer, M. L. & Perides, G. Necroptosis is an important severity determinant and potential therapeutic target in experimental severe pancreatitis. Cell Mol. Gastroenterol. Hepatol. 2, 519\u2013535 (2016).","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"1979_CR6","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.2353\/ajpath.2007.061149","volume":"170","author":"Y Cao","year":"2007","unstructured":"Cao, Y., Adhikari, S., Cl\u00e9ment, M. V., Wallig, M. & Bhatia, M. Induction of apoptosis by crambene protects mice against acute pancreatitis via anti-inflammatory pathways. Am. J. Pathol. 170, 1521\u20131534 (2007).","journal-title":"Am. J. Pathol."},{"key":"1979_CR7","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1016\/j.ymthe.2024.06.005","volume":"32","author":"Q Zhu","year":"2024","unstructured":"Zhu, Q. et al. The TRIM28\/miR133a\/CD47 axis acts as a potential therapeutic target in pancreatic necrosis by impairing efferocytosis. Mol. Ther. 32, 3025\u20133041 (2024).","journal-title":"Mol. Ther."},{"key":"1979_CR8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1136\/gut.49.2.241","volume":"49","author":"M Tashiro","year":"2001","unstructured":"Tashiro, M., Sch\u00e4fer, C., Yao, H., Ernst, S. A. & Williams, J. A. Arginine induced acute pancreatitis alters the actin cytoskeleton and increases heat shock protein expression in rat pancreatic acinar cells. Gut 49, 241\u2013250 (2001).","journal-title":"Gut"},{"key":"1979_CR9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/MPA.0b013e3182321500","volume":"41","author":"R Hoque","year":"2012","unstructured":"Hoque, R., Malik, A. F., Gorelick, F. & Mehal, W. Z. Sterile inflammatory response in acute pancreatitis. Pancreas 41, 353\u2013357 (2012).","journal-title":"Pancreas"},{"key":"1979_CR10","doi-asserted-by":"crossref","unstructured":"Zhao, Q., Wei, Y., Pandol, S. J., Li, L. & Habtezion, A. STING signaling promotes inflammation in experimental acute pancreatitis. Gastroenterology 154, 1822\u20131835.e2 (2018).","DOI":"10.1053\/j.gastro.2018.01.065"},{"key":"1979_CR11","doi-asserted-by":"crossref","unstructured":"Sendler, M. et al. NLRP3 inflammasome regulates development of systemic inflammatory response and compensatory anti-inflammatory response syndromes in mice with acute pancreatitis. Gastroenterology 158, 253\u2013269.e14 (2020).","DOI":"10.1053\/j.gastro.2019.09.040"},{"key":"1979_CR12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev-immunol-042617-053010","volume":"36","author":"S Nagata","year":"2018","unstructured":"Nagata, S. Apoptosis and clearance of apoptotic cells. Annu Rev. Immunol. 36, 489\u2013517 (2018).","journal-title":"Annu Rev. Immunol."},{"key":"1979_CR13","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni.3253","volume":"16","author":"S Arandjelovic","year":"2015","unstructured":"Arandjelovic, S. & Ravichandran, K. S. Phagocytosis of apoptotic cells in homeostasis. Nat. Immunol. 16, 907\u2013917 (2015).","journal-title":"Nat. Immunol."},{"key":"1979_CR14","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.4049\/jimmunol.1500886","volume":"196","author":"JP Vago","year":"2016","unstructured":"Vago, J. P. et al. Proresolving actions of synthetic and natural protease inhibitors are mediated by annexin A1. J. Immunol. 196, 1922\u20131932 (2016).","journal-title":"J. Immunol."},{"key":"1979_CR15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s10020-020-00213-y","volume":"26","author":"X Shen","year":"2020","unstructured":"Shen, X., Zhang, S., Guo, Z., Xing, D. & Chen, W. The crosstalk of ABCA1 and ANXA1: a potential mechanism for protection against atherosclerosis. Mol. Med 26, 84 (2020).","journal-title":"Mol. Med"},{"key":"1979_CR16","doi-asserted-by":"crossref","first-page":"6317","DOI":"10.4049\/jimmunol.1001095","volume":"185","author":"S McArthur","year":"2010","unstructured":"McArthur, S. et al. Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia. J. Immunol. 185, 6317\u20136328 (2010).","journal-title":"J. Immunol."},{"key":"1979_CR17","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1172\/JCI77014","volume":"125","author":"F Tzelepis","year":"2015","unstructured":"Tzelepis, F. et al. Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection. J. Clin. Invest. 125, 752\u2013768 (2015).","journal-title":"J. Clin. Invest."},{"key":"1979_CR18","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/cbf.3433","volume":"37","author":"GHO da Rocha","year":"2019","unstructured":"da Rocha, G. H. O. et al. Control of expression and activity of peroxisome proliferated-activated receptor \u03b3 by annexin A1 on microglia during efferocytosis. Cell Biochem. Funct. 37, 560\u2013568 (2019).","journal-title":"Cell Biochem. Funct."},{"key":"1979_CR19","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","volume":"339","author":"L Sun","year":"2013","unstructured":"Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786\u2013791 (2013).","journal-title":"Science"},{"key":"1979_CR20","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1126\/science.1240933","volume":"341","author":"D Gao","year":"2013","unstructured":"Gao, D. et al. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses. Science 341, 903\u2013906 (2013).","journal-title":"Science"},{"key":"1979_CR21","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.1229963","volume":"339","author":"J Wu","year":"2013","unstructured":"Wu, J. et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339, 826\u2013830 (2013).","journal-title":"Science"},{"key":"1979_CR22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2023.108130","volume":"65","author":"Z Wang","year":"2023","unstructured":"Wang, Z. et al. Development and applications of mRNA treatment based on lipid nanoparticles. Biotechnol. Adv. 65, 108130 (2023).","journal-title":"Biotechnol. Adv."},{"key":"1979_CR23","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.jconrel.2022.05.020","volume":"347","author":"SK Patel","year":"2022","unstructured":"Patel, S. K. et al. Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells. J. Control. Release 347, 521\u2013532 (2022).","journal-title":"J. Control. Release"},{"key":"1979_CR24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41573-023-00859-3","volume":"23","author":"D Bitounis","year":"2024","unstructured":"Bitounis, D., Jacquinet, E., Rogers, M. A. & Amiji, M. M. Strategies to reduce the risks of mRNA drug and vaccine toxicity. Nat. Rev. Drug Discov. 23, 281\u2013300 (2024).","journal-title":"Nat. Rev. Drug Discov."},{"key":"1979_CR25","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41571-023-00811-9","volume":"20","author":"E Kon","year":"2023","unstructured":"Kon, E., Ad-El, N., Hazan-Halevy, I., Stotsky-Oterin, L. & Peer, D. Targeting cancer with mRNA-lipid nanoparticles: key considerations and future prospects. Nat. Rev. Clin. Oncol. 20, 739\u2013754 (2023).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"1979_CR26","volume":"18","author":"A Kumari","year":"2023","unstructured":"Kumari, A., Kaur, A. & Aggarwal, G. The emerging potential of siRNA nanotherapeutics in treatment of arthritis. Asian J. Pharm. Sci. 18, 100845 (2023).","journal-title":"Asian J. Pharm. Sci."},{"key":"1979_CR27","volume":"22","author":"Z Li","year":"2024","unstructured":"Li, Z. et al. Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive bio-liposomes co-loaded with geniposide and emodin. J. Nanobiotechnol. 22, 129 (2024).","journal-title":"J. Nanobiotechnol."},{"key":"1979_CR28","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202400679","volume":"13","author":"S Nasra","year":"2024","unstructured":"Nasra, S., Bhatia, D. & Kumar, A. Targeted macrophage re-programming: synergistic therapy with methotrexate and RELA siRNA folate-liposome in RAW264.7 cells and arthritic rats. Adv. Health. Mater. 13, e2400679 (2024).","journal-title":"Adv. Health. Mater."},{"key":"1979_CR29","volume":"20","author":"J Ma","year":"2024","unstructured":"Ma, J., Ding, L., Peng, X., Jiang, L. & Liu, G. Recent advances of engineered cell membrane-based nanotherapeutics to combat inflammatory diseases. Small 20, e2308646 (2024).","journal-title":"Small"},{"key":"1979_CR30","doi-asserted-by":"crossref","first-page":"8423","DOI":"10.1021\/acsnano.8b03900","volume":"12","author":"Q Dai","year":"2018","unstructured":"Dai, Q. et al. Quantifying the ligand-coated nanoparticle delivery to cancer cells in solid tumors. ACS Nano 12, 8423\u20138435 (2018).","journal-title":"ACS Nano"},{"key":"1979_CR31","volume":"6","author":"H Yan","year":"2019","unstructured":"Yan, H. et al. Engineering cell membrane-based nanotherapeutics to target inflammation. Adv. Sci. 6, 1900605 (2019).","journal-title":"Adv. Sci."},{"key":"1979_CR32","doi-asserted-by":"crossref","unstructured":"Melendez, E. et al. Natural killer cells act as an extrinsic barrier for in vivo reprogramming. Development 149, dev200361 (2022).","DOI":"10.1242\/dev.200361"},{"key":"1979_CR33","doi-asserted-by":"crossref","first-page":"102920","DOI":"10.1016\/j.ebiom.2020.102920","volume":"58","author":"J Wu","year":"2020","unstructured":"Wu, J. et al. Macrophage phenotypic switch orchestrates the inflammation and repair\/regeneration following acute pancreatitis injury. eBioMedicine 58, 102920 (2020).","journal-title":"eBioMedicine"},{"key":"1979_CR34","doi-asserted-by":"crossref","unstructured":"Manohar, M. et al. Novel circulating and tissue monocytes as well as macrophages in pancreatitis and recovery. Gastroenterology 161, 2014\u20132029 (2021).","DOI":"10.1053\/j.gastro.2021.08.033"},{"key":"1979_CR35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.kint.2021.02.025","volume":"100","author":"L Wu","year":"2021","unstructured":"Wu, L. et al. Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy. Kidney Int. 100, 107\u2013121 (2021).","journal-title":"Kidney Int."},{"key":"1979_CR36","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.jcmgh.2022.07.013","volume":"14","author":"X Liu","year":"2022","unstructured":"Liu, X. et al. USP25 deficiency exacerbates acute pancreatitis via up-regulating TBK1-NF-\u03baB signaling in macrophages. Cell Mol. Gastroenterol. Hepatol. 14, 1103\u20131122 (2022).","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"1979_CR37","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nrc.2017.7","volume":"17","author":"JCM Wan","year":"2017","unstructured":"Wan, J. C. M. et al. Liquid biopsies come of age: towards implementation of circulating tumour DNA. Nat. Rev. Cancer 17, 223\u2013238 (2017).","journal-title":"Nat. Rev. Cancer"},{"key":"1979_CR38","doi-asserted-by":"crossref","unstructured":"Maltbaek, J. H., Cambier, S., Snyder, J. M. & Stetson, D. B. ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP. Immunity 55, 1799\u20131812 (2022).","DOI":"10.1016\/j.immuni.2022.08.006"},{"key":"1979_CR39","doi-asserted-by":"crossref","unstructured":"Zhou, Y. et al. Blockade of the phagocytic receptor MerTK on tumor-associated macrophages enhances P2X7R-dependent STING activation by tumor-derived cGAMP. Immunity 52, 357\u2013373.e9 (2020).","DOI":"10.1016\/j.immuni.2020.01.014"},{"key":"1979_CR40","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.biomaterials.2015.02.089","volume":"53","author":"GY Lee","year":"2015","unstructured":"Lee, G. Y. et al. Hyaluronic acid nanoparticles for active targeting atherosclerosis. Biomaterials 53, 341\u2013348 (2015).","journal-title":"Biomaterials"},{"key":"1979_CR41","volume":"11","author":"C Gao","year":"2020","unstructured":"Gao, C. et al. Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines. Nat. Commun. 11, 2622 (2020).","journal-title":"Nat. Commun."},{"key":"1979_CR42","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1080\/10717544.2018.1447050","volume":"25","author":"M Zhou","year":"2018","unstructured":"Zhou, M. et al. Targeted delivery of hyaluronic acid-coated solid lipid nanoparticles for rheumatoid arthritis therapy. Drug Deliv. 25, 716\u2013722 (2018).","journal-title":"Drug Deliv."},{"key":"1979_CR43","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.1039\/D0CS01127D","volume":"50","author":"M Sousa de Almeida","year":"2021","unstructured":"Sousa de Almeida, M. et al. Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine. Chem. Soc. Rev. 50, 5397\u20135434 (2021).","journal-title":"Chem. Soc. Rev."},{"key":"1979_CR44","doi-asserted-by":"crossref","first-page":"e1581529","DOI":"10.1080\/2162402X.2019.1581529","volume":"8","author":"Y Pan","year":"2019","unstructured":"Pan, Y. et al. Synergistic inhibition of pancreatic cancer with anti-PD-L1 and c-Myc inhibitor JQ1. Oncoimmunology 8, e1581529 (2019).","journal-title":"Oncoimmunology"},{"key":"1979_CR45","volume":"7","author":"Y Pan","year":"2017","unstructured":"Pan, Y. et al. Development of a novel model of hypertriglyceridemic acute pancreatitis in mice. Sci. Rep. 7, 40799 (2017).","journal-title":"Sci. Rep."},{"key":"1979_CR46","doi-asserted-by":"crossref","unstructured":"Sendler, M. et al. Cathepsin B-mediated activation of trypsinogen in endocytosing macrophages increases severity of pancreatitis in mice. Gastroenterology 154, 704\u2013718.e10 (2018).","DOI":"10.1053\/j.gastro.2017.10.018"},{"key":"1979_CR47","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.immuni.2014.10.019","volume":"41","author":"L Deng","year":"2014","unstructured":"Deng, L. et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors. Immunity 41, 843\u2013852 (2014).","journal-title":"Immunity"},{"key":"1979_CR48","doi-asserted-by":"crossref","unstructured":"Ahn, J., Xia, T., Rabasa Capote, A., Betancourt, D. & Barber, G. N. Extrinsic phagocyte-dependent STING signaling dictates the immunogenicity of dying cells. Cancer Cell 33, 862\u2013873.e5 (2018).","DOI":"10.1016\/j.ccell.2018.03.027"},{"key":"1979_CR49","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature12640","volume":"503","author":"A Ablasser","year":"2013","unstructured":"Ablasser, A. et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature 503, 530\u2013534 (2013).","journal-title":"Nature"},{"key":"1979_CR50","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-019-1553-0","volume":"573","author":"RD Luteijn","year":"2019","unstructured":"Luteijn, R. D. et al. SLC19A1 transports immunoreactive cyclic dinucleotides. Nature 573, 434\u2013438 (2019).","journal-title":"Nature"},{"key":"1979_CR51","doi-asserted-by":"crossref","unstructured":"Zhou, C. et al. Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity. Immunity 52, 767\u2013781.e6 (2020).","DOI":"10.1016\/j.immuni.2020.03.016"},{"key":"1979_CR52","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1096\/fj.12-213728","volume":"27","author":"A Kosicka","year":"2013","unstructured":"Kosicka, A. et al. Attenuation of plasma annexin A1 in human obesity. FASEB J. 27, 368\u2013378 (2013).","journal-title":"FASEB J."},{"key":"1979_CR53","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1042\/CS20220258","volume":"136","author":"FF De Ponti","year":"2022","unstructured":"De Ponti, F. F. & Scott, C. L. Modulating hepatic macrophages with annexin A1 in non-alcoholic steatohepatitis. Clin. Sci. 136, 1111\u20131115 (2022).","journal-title":"Clin. Sci."},{"key":"1979_CR54","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/hep.27141","volume":"60","author":"I Locatelli","year":"2014","unstructured":"Locatelli, I. et al. Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice. Hepatology 60, 531\u2013544 (2014).","journal-title":"Hepatology"},{"key":"1979_CR55","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41586-018-0735-5","volume":"563","author":"S Morioka","year":"2018","unstructured":"Morioka, S. et al. Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. Nature 563, 714\u2013718 (2018).","journal-title":"Nature"},{"key":"1979_CR56","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13045-019-0822-6","volume":"12","author":"Y Pan","year":"2019","unstructured":"Pan, Y. et al. Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer. J. Hematol. Oncol. 12, 124 (2019).","journal-title":"J. Hematol. Oncol."},{"key":"1979_CR57","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1016\/j.stemcr.2022.09.009","volume":"17","author":"D Chondronasiou","year":"2022","unstructured":"Chondronasiou, D. et al. Deciphering the roadmap of in vivo reprogramming toward pluripotency. Stem Cell Rep. 17, 2501\u20132517 (2022).","journal-title":"Stem Cell Rep."},{"key":"1979_CR58","doi-asserted-by":"crossref","first-page":"215693","DOI":"10.1016\/j.canlet.2022.215693","volume":"538","author":"R He","year":"2022","unstructured":"He, R. et al. SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer. Cancer Lett. 538, 215693 (2022).","journal-title":"Cancer Lett."},{"key":"1979_CR59","volume":"14","author":"L Li","year":"2023","unstructured":"Li, L. et al. Integrative proteogenomic characterization of early esophageal cancer. Nat. Commun. 14, 1666 (2023).","journal-title":"Nat. Commun."},{"key":"1979_CR60","doi-asserted-by":"crossref","first-page":"e2301515","DOI":"10.1002\/adhm.202301515","volume":"12","author":"AG Hamilton","year":"2023","unstructured":"Hamilton, A. G. et al. Ionizable lipid nanoparticles with integrated immune checkpoint inhibition for mRNA CAR T cell engineering. Adv. Health. Mater. 12, e2301515 (2023).","journal-title":"Adv. Health. Mater."},{"key":"1979_CR61","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41565-019-0619-3","volume":"15","author":"AM Flores","year":"2020","unstructured":"Flores, A. M. et al. Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis. Nat. Nanotechnol. 15, 154\u2013161 (2020).","journal-title":"Nat. Nanotechnol."}],"container-title":["Nature Nanotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41565-025-01979-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41565-025-01979-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41565-025-01979-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T16:08:04Z","timestamp":1760717284000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41565-025-01979-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["1979"],"URL":"https:\/\/doi.org\/10.1038\/s41565-025-01979-0","relation":{},"ISSN":["1748-3387","1748-3395"],"issn-type":[{"value":"1748-3387","type":"print"},{"value":"1748-3395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"6 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"J.C. is a co-founder and shareholder of TargTex S.A. Targeted therapeutics for Glioblastoma Multiforme. J.C. is also a member of the Global Burden Disease (GBD) consortium from Institute for Health Metrics and Evaluation (IHME), University of Washington. Y.P., F. Liang and P.Y. are authors of a provisional patent (202411349874.8, China) based on this paper. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}