{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:28:54Z","timestamp":1794000534837,"version":"4.8.0"},"reference-count":161,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T00:00:00Z","timestamp":1534291200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Cardiol"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1038\/s41569-018-0063-3","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T13:35:51Z","timestamp":1534340151000},"page":"672-684","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":377,"title":["The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration"],"prefix":"10.1038","volume":"15","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-5416","authenticated-orcid":false,"given":"Shijie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Heallen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,15]]},"reference":[{"key":"63_CR1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2006.01.005","volume":"124","author":"BA Edgar","year":"2006","unstructured":"Edgar, B. A. From cell structure to transcription: Hippo forges a new path. Cell 124, 267\u2013273 (2006).","journal-title":"Cell"},{"key":"63_CR2","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1242\/dev.102376","volume":"141","author":"X Varelas","year":"2014","unstructured":"Varelas, X. The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Development 141, 1614\u20131626 (2014).","journal-title":"Development"},{"key":"63_CR3","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1177\/0022034517719886","volume":"96","author":"J Wang","year":"2017","unstructured":"Wang, J. & Martin, J. F. Hippo pathway: an emerging regulator of craniofacial and dental development. J. Dent. Res. 96, 1229\u20131237 (2017).","journal-title":"J. Dent. Res."},{"key":"63_CR4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11936-016-0461-y","volume":"18","author":"Y Xiao","year":"2016","unstructured":"Xiao, Y., Leach, J., Wang, J. & Martin, J. F. Hippo\/Yap signaling in cardiac development and regeneration. Curr. Treat. Options Cardiovasc. Med. 18, 38 (2016).","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"63_CR5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ceb.2017.12.012","volume":"49","author":"V Fu","year":"2017","unstructured":"Fu, V., Plouffe, S. W. & Guan, K. L. The Hippo pathway in organ development, homeostasis, and regeneration. Curr. Opin. Cell Biol. 49, 99\u2013107 (2017).","journal-title":"Curr. Opin. Cell Biol."},{"key":"63_CR6","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1253\/circj.CJ-16-0476","volume":"80","author":"S Ikeda","year":"2016","unstructured":"Ikeda, S. & Sadoshima, J. Regulation of myocardial cell growth and death by the Hippo pathway. Circ. J. 80, 1511\u20131519 (2016).","journal-title":"Circ. J."},{"key":"63_CR7","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.1199010","volume":"332","author":"T Heallen","year":"2011","unstructured":"Heallen, T. et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 332, 458\u2013461 (2011).","journal-title":"Science"},{"key":"63_CR8","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","volume":"135","author":"EJ Benjamin","year":"2017","unstructured":"Benjamin, E. J. et al. Heart disease and stroke statistics-2017 update: a report from the American Heart Association. Circulation 135, e146\u2013e603 (2017).","journal-title":"Circulation"},{"key":"63_CR9","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1242\/dev.102798","volume":"140","author":"T Heallen","year":"2013","unstructured":"Heallen, T. et al. Hippo signaling impedes adult heart regeneration. Development 140, 4683\u20134690 (2013).","journal-title":"Development"},{"key":"63_CR10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature24045","volume":"550","author":"JP Leach","year":"2017","unstructured":"Leach, J. P. et al. Hippo pathway deficiency reverses systolic heart failure after infarction. Nature 550, 260\u2013264 (2017).","journal-title":"Nature"},{"key":"63_CR11","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCRESAHA.115.303632","volume":"115","author":"Z Lin","year":"2014","unstructured":"Lin, Z. et al. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ. Res. 115, 354\u2013363 (2014).","journal-title":"Circ. Res."},{"key":"63_CR12","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1073\/pnas.1313192110","volume":"110","author":"M Xin","year":"2013","unstructured":"Xin, M. et al. Hippo pathway effector Yap promotes cardiac regeneration. Proc. Natl Acad. Sci. USA 110, 13839\u201313844 (2013).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"63_CR13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.molcel.2013.05.013","volume":"51","author":"J Wang","year":"2013","unstructured":"Wang, J. et al. TRIB2 acts downstream of Wnt\/TCF in liver cancer cells to regulate YAP and C\/EBPalpha function. Mol. Cell 51, 211\u2013225 (2013).","journal-title":"Mol. Cell"},{"key":"63_CR14","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1002\/hep.25899","volume":"56","author":"T Zhang","year":"2012","unstructured":"Zhang, T. et al. Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells. Hepatology 56, 2051\u20132059 (2012).","journal-title":"Hepatology"},{"key":"63_CR15","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/onc.2008.461","volume":"28","author":"M Zagurovskaya","year":"2009","unstructured":"Zagurovskaya, M. et al. EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells. Oncogene 28, 1121\u20131131 (2009).","journal-title":"Oncogene"},{"key":"63_CR16","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.ccell.2015.05.005","volume":"27","author":"LT Nguyen","year":"2015","unstructured":"Nguyen, L. T. et al. ERG activates the YAP1 transcriptional program and induces the development of age-related prostate tumors. Cancer Cell 27, 797\u2013808 (2015).","journal-title":"Cancer Cell"},{"key":"63_CR17","doi-asserted-by":"crossref","first-page":"33334","DOI":"10.1074\/jbc.M305597200","volume":"278","author":"A Komuro","year":"2003","unstructured":"Komuro, A., Nagai, M., Navin, N. E. & Sudol, M. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J. Biol. Chem. 278, 33334\u201333341 (2003).","journal-title":"J. Biol. Chem."},{"key":"63_CR18","doi-asserted-by":"crossref","first-page":"ra42","DOI":"10.1126\/scisignal.2005049","volume":"7","author":"W Zhang","year":"2014","unstructured":"Zhang, W. et al. Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma. Sci. Signal. 7, ra42 (2014).","journal-title":"Sci. Signal."},{"key":"63_CR19","volume":"5","author":"D Shao","year":"2014","unstructured":"Shao, D. et al. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat. Commun. 5, 3315 (2014).","journal-title":"Nat. Commun."},{"key":"63_CR20","doi-asserted-by":"crossref","first-page":"E3402","DOI":"10.1073\/pnas.1420005112","volume":"112","author":"TS Eisinger-Mathason","year":"2015","unstructured":"Eisinger-Mathason, T. S. et al. Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis. Proc. Natl Acad. Sci. USA 112, E3402\u2013E3411 (2015).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"63_CR21","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1016\/j.ejca.2013.03.002","volume":"49","author":"P Bendinelli","year":"2013","unstructured":"Bendinelli, P. et al. Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer. Eur. J. Cancer 49, 2608\u20132618 (2013).","journal-title":"Eur. J. Cancer"},{"key":"63_CR22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncb3073","volume":"17","author":"B Ma","year":"2015","unstructured":"Ma, B. et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat. Cell Biol. 17, 95\u2013103 (2015).","journal-title":"Nat. Cell Biol."},{"key":"63_CR23","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2014.27","volume":"3","author":"M Tariki","year":"2014","unstructured":"Tariki, M. et al. The Yes-associated protein controls the cell density regulation of Hedgehog signaling. Oncogenesis 3, e112 (2014).","journal-title":"Oncogenesis"},{"key":"63_CR24","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1016\/j.ajpath.2012.02.025","volume":"180","author":"X Zhi","year":"2012","unstructured":"Zhi, X., Zhao, D., Zhou, Z., Liu, R. & Chen, C. YAP promotes breast cell proliferation and survival partially through stabilizing the KLF5 transcription factor. Am. J. Pathol. 180, 2452\u20132461 (2012).","journal-title":"Am. J. Pathol."},{"key":"63_CR25","doi-asserted-by":"crossref","first-page":"15173","DOI":"10.3390\/ijms150915173","volume":"15","author":"Y Gao","year":"2014","unstructured":"Gao, Y. et al. Curcumin promotes KLF5 proteasome degradation through downregulating YAP\/TAZ in bladder cancer cells. Int. J. Mol. Sci. 15, 15173\u201315187 (2014).","journal-title":"Int. J. Mol. Sci."},{"key":"63_CR26","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1096\/fj.09-151324","volume":"24","author":"H Jeong","year":"2010","unstructured":"Jeong, H. et al. TAZ as a novel enhancer of MyoD-mediated myogenic differentiation. FASEB J. 24, 3310\u20133320 (2010).","journal-title":"FASEB J."},{"key":"63_CR27","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.celrep.2013.11.021","volume":"5","author":"TA Beyer","year":"2013","unstructured":"Beyer, T. A. et al. Switch enhancers interpret TGF-beta and Hippo signaling to control cell fate in human embryonic stem cells. Cell Rep. 5, 1611\u20131624 (2013).","journal-title":"Cell Rep."},{"key":"63_CR28","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.bbrc.2005.10.214","volume":"339","author":"M Murakami","year":"2006","unstructured":"Murakami, M. et al. Transcriptional activity of Pax3 is co-activated by TAZ. Biochem. Biophys. Res. Commun. 339, 533\u2013539 (2006).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"63_CR29","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.celrep.2014.10.061","volume":"9","author":"LJ Manderfield","year":"2014","unstructured":"Manderfield, L. J. et al. Pax3 and hippo signaling coordinate melanocyte gene expression in neural crest. Cell Rep. 9, 1885\u20131895 (2014).","journal-title":"Cell Rep."},{"key":"63_CR30","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature17959","volume":"534","author":"G Tao","year":"2016","unstructured":"Tao, G. et al. Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Nature 534, 119\u2013123 (2016).","journal-title":"Nature"},{"key":"63_CR31","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1110955","volume":"309","author":"JH Hong","year":"2005","unstructured":"Hong, J. H. et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309, 1074\u20131078 (2005).","journal-title":"Science"},{"key":"63_CR32","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4161\/cc.9.1.10321","volume":"9","author":"A Chatterjee","year":"2010","unstructured":"Chatterjee, A., Sen, T., Chang, X. & Sidransky, D. Yes-associated protein 1 regulates the stability of DeltaNp63alpha. Cell Cycle 9, 162\u2013167 (2010).","journal-title":"Cell Cycle"},{"key":"63_CR33","doi-asserted-by":"crossref","first-page":"16906","DOI":"10.1074\/jbc.M115.642363","volume":"290","author":"I Valencia-Sama","year":"2015","unstructured":"Valencia-Sama, I. et al. Hippo component TAZ functions as a co-repressor and negatively regulates DeltaNp63 transcription through TEA domain (TEAD) transcription factor. J. Biol. Chem. 290, 16906\u201316917 (2015).","journal-title":"J. Biol. Chem."},{"key":"63_CR34","doi-asserted-by":"crossref","first-page":"15164","DOI":"10.1074\/jbc.M010484200","volume":"276","author":"S Strano","year":"2001","unstructured":"Strano, S. et al. Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J. Biol. Chem. 276, 15164\u201315173 (2001).","journal-title":"J. Biol. Chem."},{"key":"63_CR35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1097-2765(02)00776-1","volume":"11","author":"S Basu","year":"2003","unstructured":"Basu, S., Totty, N. F., Irwin, M. S., Sudol, M. & Downward, J. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol. Cell 11, 11\u201323 (2003).","journal-title":"Mol. Cell"},{"key":"63_CR36","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.molcel.2008.11.019","volume":"32","author":"E Lapi","year":"2008","unstructured":"Lapi, E. et al. PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop. Mol. Cell 32, 803\u2013814 (2008).","journal-title":"Mol. Cell"},{"key":"63_CR37","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1093\/emboj\/18.9.2551","volume":"18","author":"R Yagi","year":"1999","unstructured":"Yagi, R., Chen, L. F., Shigesada, K., Murakami, Y. & Ito, Y. A. WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J. 18, 2551\u20132562 (1999).","journal-title":"EMBO J."},{"key":"63_CR38","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1128\/MCB.23.3.1004-1013.2003","volume":"23","author":"CB Cui","year":"2003","unstructured":"Cui, C. B., Cooper, L. F., Yang, X., Karsenty, G. & Aukhil, I. Transcriptional coactivation of bone-specific transcription factor Cbfa1 by TAZ. Mol. Cell. Biol. 23, 1004\u20131013 (2003).","journal-title":"Mol. Cell. Biol."},{"key":"63_CR39","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.molcel.2007.12.022","volume":"29","author":"D Levy","year":"2008","unstructured":"Levy, D., Adamovich, Y., Reuven, N. & Shaul, Y. Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol. Cell 29, 350\u2013361 (2008).","journal-title":"Mol. Cell"},{"key":"63_CR40","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1038\/sj.onc.1205623","volume":"21","author":"O Ferrigno","year":"2002","unstructured":"Ferrigno, O. et al. Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta\/Smad signaling. Oncogene 21, 4879\u20134884 (2002).","journal-title":"Oncogene"},{"key":"63_CR41","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/ncb1748","volume":"10","author":"X Varelas","year":"2008","unstructured":"Varelas, X. et al. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat. Cell Biol. 10, 837\u2013848 (2008).","journal-title":"Nat. Cell Biol."},{"key":"63_CR42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.devcel.2008.06.010","volume":"15","author":"KH Wrighton","year":"2008","unstructured":"Wrighton, K. H., Dai, F. & Feng, X. H. A new kid on the TGFbeta block: TAZ controls Smad nucleocytoplasmic shuttling. Dev. Cell 15, 8\u201310 (2008).","journal-title":"Dev. Cell"},{"key":"63_CR43","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.cell.2009.09.035","volume":"139","author":"C Alarcon","year":"2009","unstructured":"Alarcon, C. et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell 139, 757\u2013769 (2009).","journal-title":"Cell"},{"key":"63_CR44","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.devcel.2010.11.012","volume":"19","author":"X Varelas","year":"2010","unstructured":"Varelas, X. et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. Dev. Cell 19, 831\u2013844 (2010).","journal-title":"Dev. Cell"},{"key":"63_CR45","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1084\/jem.20111653","volume":"209","author":"M Fujii","year":"2012","unstructured":"Fujii, M. et al. TGF-beta synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. J. Exp. Med. 209, 479\u2013494 (2012).","journal-title":"J. Exp. Med."},{"key":"63_CR46","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.devcel.2015.02.019","volume":"32","author":"M Narimatsu","year":"2015","unstructured":"Narimatsu, M., Samavarchi-Tehrani, P., Varelas, X. & Wrana, J. L. Distinct polarity cues direct Taz\/Yap and TGFbeta receptor localization to differentially control TGFbeta-induced Smad signaling. Dev. Cell 32, 652\u2013656 (2015).","journal-title":"Dev. Cell"},{"key":"63_CR47","doi-asserted-by":"crossref","first-page":"18034","DOI":"10.1073\/pnas.0509109102","volume":"102","author":"M Murakami","year":"2005","unstructured":"Murakami, M., Nakagawa, M., Olson, E. N. & Nakagawa, O. A. WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc. Natl Acad. Sci. USA 102, 18034\u201318039 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"63_CR48","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.cell.2012.11.026","volume":"151","author":"J Rosenbluh","year":"2012","unstructured":"Rosenbluh, J. et al. beta-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis. Cell 151, 1457\u20131473 (2012).","journal-title":"Cell"},{"key":"63_CR49","doi-asserted-by":"crossref","first-page":"17384","DOI":"10.1074\/jbc.M312569200","volume":"279","author":"KS Park","year":"2004","unstructured":"Park, K. S. et al. TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J. Biol. Chem. 279, 17384\u201317390 (2004).","journal-title":"J. Biol. Chem."},{"key":"63_CR50","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14582","volume":"8","author":"CV Ragni","year":"2017","unstructured":"Ragni, C. V. et al. Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat. Commun. 8, 14582 (2017).","journal-title":"Nat. Commun."},{"key":"63_CR51","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14058","volume":"8","author":"S Jiao","year":"2017","unstructured":"Jiao, S. et al. VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. Nat. Commun. 8, 14058 (2017).","journal-title":"Nat. Commun."},{"key":"63_CR52","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ccr.2014.01.010","volume":"25","author":"S Jiao","year":"2014","unstructured":"Jiao, S. et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell 25, 166\u2013180 (2014).","journal-title":"Cancer Cell"},{"key":"63_CR53","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/cr.2014.10","volume":"24","author":"W Zhang","year":"2014","unstructured":"Zhang, W. et al. VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell Res. 24, 331\u2013343 (2014).","journal-title":"Cell Res."},{"key":"63_CR54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.devcel.2010.06.015","volume":"19","author":"N Zhang","year":"2010","unstructured":"Zhang, N. et al. The Merlin\/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev. Cell 19, 27\u201338 (2010).","journal-title":"Dev. Cell"},{"key":"63_CR55","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/CIRCRESAHA.116.308586","volume":"119","author":"T Matsuda","year":"2016","unstructured":"Matsuda, T. et al. NF2 activates hippo signaling and promotes ischemia\/reperfusion injury in the heart. Circ. Res. 119, 596\u2013606 (2016).","journal-title":"Circ. Res."},{"key":"63_CR56","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/35082103","volume":"411","author":"J Brennan","year":"2001","unstructured":"Brennan, J. et al. Nodal signalling in the epiblast patterns the early mouse embryo. Nature 411, 965\u2013969 (2001).","journal-title":"Nature"},{"key":"63_CR57","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ncb3024","volume":"16","author":"F Lescroart","year":"2014","unstructured":"Lescroart, F. et al. Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development. Nat. Cell Biol. 16, 829\u2013840 (2014).","journal-title":"Nat. Cell Biol."},{"key":"63_CR58","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1242\/dev.091538","volume":"141","author":"D Sp\u00e4ter","year":"2014","unstructured":"Sp\u00e4ter, D., Hansson, E. M., Zangi, L. & Chien, K. R. How to make a cardiomyocyte. Development 141, 4418\u20134431 (2014).","journal-title":"Development"},{"key":"63_CR59","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1242\/dev.015321","volume":"135","author":"Q Yue","year":"2008","unstructured":"Yue, Q., Wagstaff, L., Yang, X., Weijer, C. & Munsterberg, A. Wnt3a-mediated chemorepulsion controls movement patterns of cardiac progenitors and requires RhoA function. Development 135, 1029\u20131037 (2008).","journal-title":"Development"},{"key":"63_CR60","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/cvr\/cvr127","volume":"91","author":"C Lopez-Sanchez","year":"2011","unstructured":"Lopez-Sanchez, C. & Garcia-Martinez, V. Molecular determinants of cardiac specification. Cardiovasc. Res. 91, 185\u2013195 (2011).","journal-title":"Cardiovasc. Res."},{"key":"63_CR61","doi-asserted-by":"crossref","first-page":"19812","DOI":"10.1073\/pnas.0605768103","volume":"103","author":"AT Naito","year":"2006","unstructured":"Naito, A. T. et al. Developmental stage-specific biphasic roles of Wnt\/\u03b2-catenin signaling in cardiomyogenesis and hematopoiesis. Proc. Natl Acad. Sci. USA 103, 19812\u201319817 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"63_CR62","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1161\/CIRCRESAHA.116.309040","volume":"120","author":"FX Galdos","year":"2017","unstructured":"Galdos, F. X. et al. Cardiac regeneration: lessons from development. Circ. Res. 120, 941\u2013959 (2017).","journal-title":"Circ. Res."},{"key":"63_CR63","doi-asserted-by":"crossref","first-page":"9319","DOI":"10.1073\/pnas.0701212104","volume":"104","author":"D Ai","year":"2007","unstructured":"Ai, D. et al. Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc. Natl Acad. Sci. USA 104, 9319\u20139324 (2007).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"63_CR64","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1126\/science.1132292","volume":"313","author":"EN Olson","year":"2006","unstructured":"Olson, E. N. Gene regulatory networks in the evolution and development of the heart. Science 313, 1922\u20131927 (2006).","journal-title":"Science"},{"key":"63_CR65","unstructured":"Meilhac, S. M. & Buckingham, M. E. The deployment of cell lineages that form the mammalian heart. Nat. Rev. Cardiol. (in the press)."},{"key":"63_CR66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2153(10)90001-X","volume":"90","author":"SD Vincent","year":"2010","unstructured":"Vincent, S. D. & Buckingham, M. E. How to make a heart: the origin and regulation of cardiac progenitor cells. Curr. Top. Dev. Biol. 90, 1\u201341 (2010).","journal-title":"Curr. Top. Dev. Biol."},{"key":"63_CR67","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1073\/pnas.1116136109","volume":"109","author":"A Gise von","year":"2012","unstructured":"von Gise, A. et al. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc. Natl Acad. Sci. USA 109, 2394\u20132399 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"63_CR68","first-page":"ra70","volume":"4","author":"M Xin","year":"2011","unstructured":"Xin, M. et al. Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci. Signal. 4, ra70 (2011).","journal-title":"Sci. Signal."},{"key":"63_CR69","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/gene.10022","volume":"31","author":"KA Moses","year":"2001","unstructured":"Moses, K. A., DeMayo, F., Braun, R. M., Reecy, J. L. & Schwartz, R. J. Embryonic expression of an Nkx2-5\/Cre gene using ROSA26 reporter mice. Genesis 31, 176\u2013180 (2001).","journal-title":"Genesis"},{"key":"63_CR70","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1101\/gad.8.19.2293","volume":"8","author":"Z Chen","year":"1994","unstructured":"Chen, Z., Friedrich, G. A. & Soriano, P. Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 8, 2293\u20132301 (1994).","journal-title":"Genes Dev."},{"key":"63_CR71","doi-asserted-by":"crossref","first-page":"13721","DOI":"10.1074\/jbc.M109.063057","volume":"285","author":"RW Tsika","year":"2010","unstructured":"Tsika, R. W. et al. TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. J. Biol. Chem. 285, 13721\u201313735 (2010).","journal-title":"J. Biol. Chem."},{"key":"63_CR72","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.devcel.2018.03.019","volume":"45","author":"Y Xiao","year":"2018","unstructured":"Xiao, Y. et al. Hippo signaling plays an essential role in cell state transitions during cardiac fibroblast development. Dev. Cell 45, 153\u2013169.e6 (2018).","journal-title":"Dev. Cell"},{"key":"63_CR73","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.devcel.2012.01.012","volume":"22","author":"TC Katz","year":"2012","unstructured":"Katz, T. C. et al. Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Dev. Cell 22, 639\u2013650 (2012).","journal-title":"Dev. Cell"},{"key":"63_CR74","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1242\/dev.079970","volume":"139","author":"A Acharya","year":"2012","unstructured":"Acharya, A. et al. The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors. Development 139, 2139\u20132149 (2012).","journal-title":"Development"},{"key":"63_CR75","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ar.a.10129","volume":"276","author":"A Wessels","year":"2004","unstructured":"Wessels, A. & Perez-Pomares, J. M. The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells. Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 276, 43\u201357 (2004).","journal-title":"Anat. Rec. A Discov. Mol. Cell. Evol. Biol."},{"key":"63_CR76","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.celrep.2016.04.027","volume":"15","author":"A Singh","year":"2016","unstructured":"Singh, A. et al. Hippo signaling mediators Yap and Taz are required in the epicardium for coronary vasculature development. Cell Rep. 15, 1384\u20131393 (2016).","journal-title":"Cell Rep."},{"key":"63_CR77","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.devcel.2010.03.007","volume":"18","author":"X Varelas","year":"2010","unstructured":"Varelas, X. et al. The Hippo pathway regulates Wnt\/beta-catenin signaling. Dev. Cell 18, 579\u2013591 (2010).","journal-title":"Dev. Cell"},{"key":"63_CR78","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","volume":"331","author":"ER Porrello","year":"2011","unstructured":"Porrello, E. R. et al. Transient regenerative potential of the neonatal mouse heart. Science 331, 1078\u20131080 (2011).","journal-title":"Science"},{"key":"63_CR79","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/ncb2615","volume":"14","author":"K Tumaneng","year":"2012","unstructured":"Tumaneng, K. et al. YAP mediates crosstalk between the Hippo and PI(3)K-TOR pathways by suppressing PTEN via miR-29. Nat. Cell Biol. 14, 1322\u20131329 (2012).","journal-title":"Nat. Cell Biol."},{"key":"63_CR80","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1152\/physrev.00032.2006","volume":"87","author":"P Ahuja","year":"2007","unstructured":"Ahuja, P., Sdek, P. & MacLellan, W. R. Cardiac myocyte cell cycle control in development, disease, and regeneration. Physiol. Rev. 87, 521\u2013544 (2007).","journal-title":"Physiol. Rev."},{"key":"63_CR81","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","volume":"109","author":"N Frey","year":"2004","unstructured":"Frey, N., Katus, H. A., Olson, E. N. & Hill, J. A. Hypertrophy of the heart: a new therapeutic target? Circulation 109, 1580\u20131589 (2004).","journal-title":"Circulation"},{"key":"63_CR82","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1152\/physrev.00024.2007","volume":"88","author":"E Murphy","year":"2008","unstructured":"Murphy, E. & Steenbergen, C. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol. Rev. 88, 581\u2013609 (2008).","journal-title":"Physiol. Rev."},{"key":"63_CR83","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1074\/jbc.M112.436311","volume":"288","author":"Re,DP Del","year":"2013","unstructured":"Del, Re,D. P. et al. Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J. Biol. Chem. 288, 3977\u20133988 (2013).","journal-title":"J. Biol. Chem."},{"key":"63_CR84","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/CIRCRESAHA.115.306624","volume":"117","author":"Y Yang","year":"2015","unstructured":"Yang, Y. et al. miR-206 mediates YAP-induced cardiac hypertrophy and survival. Circ. Res. 117, 891\u2013904 (2015).","journal-title":"Circ. Res."},{"key":"63_CR85","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00395-014-0435-8","volume":"109","author":"P Wang","year":"2014","unstructured":"Wang, P. et al. The alteration of Hippo\/YAP signaling in the development of hypertrophic cardiomyopathy. Basic Res. Cardiol. 109, 435 (2014).","journal-title":"Basic Res. Cardiol."},{"key":"63_CR86","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1172\/JCI17459","volume":"111","author":"S Yamamoto","year":"2003","unstructured":"Yamamoto, S. et al. Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J. Clin. Invest. 111, 1463\u20131474 (2003).","journal-title":"J. Clin. Invest."},{"key":"63_CR87","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1161\/01.RES.0000265846.23485.7a","volume":"100","author":"M Odashima","year":"2007","unstructured":"Odashima, M. et al. Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circ. Res. 100, 1344\u20131352 (2007).","journal-title":"Circ. Res."},{"key":"63_CR88","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1172\/JCI43569","volume":"120","author":"Re,DP Del","year":"2010","unstructured":"Del, Re,D. P. et al. Proapoptotic Rassf1A\/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. J. Clin. Invest. 120, 3555\u20133567 (2010).","journal-title":"J. Clin. Invest."},{"key":"63_CR89","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/CIRCULATIONAHA.109.868554","volume":"120","author":"D Oceandy","year":"2009","unstructured":"Oceandy, D. et al. Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy. Circulation 120, 607\u2013616 (2009).","journal-title":"Circulation"},{"key":"63_CR90","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1161\/CIRCRESAHA.108.180042","volume":"103","author":"Y Matsui","year":"2008","unstructured":"Matsui, Y. et al. Lats2 is a negative regulator of myocyte size in the heart. Circ. Res. 103, 1309\u20131318 (2008).","journal-title":"Circ. Res."},{"key":"63_CR91","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/CIRCRESAHA.114.302810","volume":"114","author":"SN Chen","year":"2014","unstructured":"Chen, S. N. et al. The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy. Circ. Res. 114, 454\u2013468 (2014).","journal-title":"Circ. Res."},{"key":"63_CR92","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/jez.1401870208","volume":"187","author":"JO Oberpriller","year":"1974","unstructured":"Oberpriller, J. O. & Oberpriller, J. C. Response of the adult newt ventricle to injury. J. Exp. Zool. 187, 249\u2013253 (1974).","journal-title":"J. Exp. Zool."},{"key":"63_CR93","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1126\/science.1077857","volume":"298","author":"KD Poss","year":"2002","unstructured":"Poss, K. D., Wilson, L. G. & Keating, M. T. Heart regeneration in zebrafish. Science 298, 2188\u20132190 (2002).","journal-title":"Science"},{"key":"63_CR94","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1073\/pnas.1208863110","volume":"110","author":"ER Porrello","year":"2013","unstructured":"Porrello, E. R. et al. Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proc. Natl Acad. Sci. USA 110, 187\u2013192 (2013).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"63_CR95","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1161\/CIRCULATIONAHA.109.192666","volume":"121","author":"D Lloyd-Jones","year":"2010","unstructured":"Lloyd-Jones, D. et al. Executive summary: heart disease and stroke statistics\u20142010 update: a report from the American Heart Association. Circulation 121, 948\u2013954 (2010).","journal-title":"Circulation"},{"key":"63_CR96","first-page":"e46","volume":"121","author":"Writing Group Members","year":"2010","unstructured":"Writing Group Members. et al. Heart disease and stroke statistics\u20142010 update: a report from the American Heart Association. Circulation 121, e46\u2013e215 (2010).","journal-title":"Circulation"},{"key":"63_CR97","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nature08899","volume":"464","author":"C Jopling","year":"2010","unstructured":"Jopling, C. et al. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature 464, 606\u2013609 (2010).","journal-title":"Nature"},{"key":"63_CR98","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nature08804","volume":"464","author":"K Kikuchi","year":"2010","unstructured":"Kikuchi, K. et al. Primary contribution to zebrafish heart regeneration by gata4(\u2009+\u2009) cardiomyocytes. Nature 464, 601\u2013605 (2010).","journal-title":"Nature"},{"key":"63_CR99","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.ceb.2008.10.001","volume":"20","author":"B Zhao","year":"2008","unstructured":"Zhao, B., Lei, Q. Y. & Guan, K. L. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr. Opin. Cell Biol. 20, 638\u2013646 (2008).","journal-title":"Curr. Opin. Cell Biol."},{"key":"63_CR100","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2010.09.011","volume":"19","author":"D Pan","year":"2010","unstructured":"Pan, D. The hippo signaling pathway in development and cancer. Dev. Cell 19, 491\u2013505 (2010).","journal-title":"Dev. Cell"},{"key":"63_CR101","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI119509","volume":"100","author":"R Agah","year":"1997","unstructured":"Agah, R. et al. Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J. Clin. Invest. 100, 169\u2013179 (1997).","journal-title":"J. Clin. Invest."},{"key":"63_CR102","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/CIRCRESAHA.116.304472","volume":"116","author":"J Li","year":"2015","unstructured":"Li, J. et al. Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity. Circ. Res. 116, 70\u201379 (2015).","journal-title":"Circ. Res."},{"key":"63_CR103","doi-asserted-by":"crossref","first-page":"dev149823","DOI":"10.1242\/dev.149823","volume":"145","author":"A Vite","year":"2018","unstructured":"Vite, A., Zhang, C., Yi, R., Emms, S. & Radice, G. L. Alpha-catenin-dependent cytoskeletal tension controls Yap activity in the heart. Development 145, dev149823 (2018).","journal-title":"Development"},{"key":"63_CR104","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.devcel.2016.09.005","volume":"39","author":"Z Lin","year":"2016","unstructured":"Lin, Z. et al. Acetylation of VGLL4 regulates Hippo-YAP signaling and postnatal cardiac growth. Dev. Cell 39, 466\u2013479 (2016).","journal-title":"Dev. Cell"},{"key":"63_CR105","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","volume":"324","author":"O Bergmann","year":"2009","unstructured":"Bergmann, O. et al. Evidence for cardiomyocyte renewal in humans. Science 324, 98\u2013102 (2009).","journal-title":"Science"},{"key":"63_CR106","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1152\/physrev.1992.72.2.507","volume":"72","author":"J Girard","year":"1992","unstructured":"Girard, J., Ferre, P., Pegorier, J. P. & Duee, P. H. Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition. Physiol. Rev. 72, 507\u2013562 (1992).","journal-title":"Physiol. Rev."},{"key":"63_CR107","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/FJC.0b013e3181e74a14","volume":"56","author":"GD Lopaschuk","year":"2010","unstructured":"Lopaschuk, G. D. & Jaswal, J. S. Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation. J. Cardiovasc. Pharmacol. 56, 130\u2013140 (2010).","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"63_CR108","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1096\/fj.14-264093","volume":"29","author":"CB Sim","year":"2015","unstructured":"Sim, C. B. et al. Dynamic changes in the cardiac methylome during postnatal development. FASEB J. 29, 1329\u20131343 (2015).","journal-title":"FASEB J."},{"key":"63_CR109","doi-asserted-by":"crossref","first-page":"E8372","DOI":"10.1073\/pnas.1707316114","volume":"114","author":"RJ Mills","year":"2017","unstructured":"Mills, R. J. et al. Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proc. Natl Acad. Sci. USA 114, E8372\u2013E8381 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"63_CR110","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/CIRCRESAHA.111.243196","volume":"110","author":"M Coggins","year":"2012","unstructured":"Coggins, M. & Rosenzweig, A. The fire within: cardiac inflammatory signaling in health and disease. Circ. Res. 110, 116\u2013125 (2012).","journal-title":"Circ. Res."},{"key":"63_CR111","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1172\/JCI72181","volume":"124","author":"AB Aurora","year":"2014","unstructured":"Aurora, A. B. et al. Macrophages are required for neonatal heart regeneration. J. Clin. Invest. 124, 1382\u20131392 (2014).","journal-title":"J. Clin. Invest."},{"key":"63_CR112","doi-asserted-by":"crossref","first-page":"818","DOI":"10.2353\/ajpath.2007.060547","volume":"170","author":"MJ Amerongen van","year":"2007","unstructured":"van Amerongen, M. J., Harmsen, M. C., van Rooijen, N., Petersen, A. H. & van Luyn, M. J. Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice. Am. J. Pathol. 170, 818\u2013829 (2007).","journal-title":"Am. J. Pathol."},{"key":"63_CR113","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137515","volume":"10","author":"AL Leblond","year":"2015","unstructured":"Leblond, A. L. et al. Systemic and cardiac depletion of M2 macrophage through CSF-1R signaling inhibition alters cardiac function post myocardial infarction. PLoS ONE 10, e0137515 (2015).","journal-title":"PLoS ONE"},{"key":"63_CR114","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/01.RES.0000246113.82111.2d","volume":"99","author":"H Morimoto","year":"2006","unstructured":"Morimoto, H. et al. Cardiac overexpression of monocyte chemoattractant protein-1 in transgenic mice prevents cardiac dysfunction and remodeling after myocardial infarction. Circ. Res. 99, 891\u2013899 (2006).","journal-title":"Circ. Res."},{"key":"63_CR115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14228","volume":"519","author":"K Taniguchi","year":"2015","unstructured":"Taniguchi, K. et al. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature 519, 57\u201362 (2015).","journal-title":"Nature"},{"key":"63_CR116","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","volume":"157","author":"BN Puente","year":"2014","unstructured":"Puente, B. N. et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell 157, 565\u2013579 (2014).","journal-title":"Cell"},{"key":"63_CR117","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.cell.2006.03.046","volume":"125","author":"MK Lehtinen","year":"2006","unstructured":"Lehtinen, M. K. et al. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125, 987\u20131001 (2006).","journal-title":"Cell"},{"key":"63_CR118","doi-asserted-by":"crossref","first-page":"ra41","DOI":"10.1126\/scisignal.2005781","volume":"8","author":"Y Morikawa","year":"2015","unstructured":"Morikawa, Y. et al. Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice. Sci. Signal. 8, ra41 (2015).","journal-title":"Sci. Signal."},{"key":"63_CR119","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/nm.3322","volume":"19","author":"Y Maejima","year":"2013","unstructured":"Maejima, Y. et al. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat. Med. 19, 1478\u20131488 (2013).","journal-title":"Nat. Med."},{"key":"63_CR120","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1126\/science.1229765","volume":"338","author":"GN Huang","year":"2012","unstructured":"Huang, G. N. et al. C\/EBP transcription factors mediate epicardial activation during heart development and injury. Science 338, 1599\u20131603 (2012).","journal-title":"Science"},{"key":"63_CR121","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044692","volume":"7","author":"B Wijk van","year":"2012","unstructured":"van Wijk, B., Gunst, Q. D., Moorman, A. F. & van den Hoff, M. J. Cardiac regeneration from activated epicardium. PLoS ONE 7, e44692 (2012).","journal-title":"PLoS ONE"},{"key":"63_CR122","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ydbio.2013.08.012","volume":"382","author":"J Wang","year":"2013","unstructured":"Wang, J., Karra, R., Dickson, A. L. & Poss, K. D. Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. Dev. Biol. 382, 427\u2013435 (2013).","journal-title":"Dev. Biol."},{"key":"63_CR123","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nature10188","volume":"474","author":"N Smart","year":"2011","unstructured":"Smart, N. et al. De novo cardiomyocytes from within the activated adult heart after injury. Nature 474, 640\u2013644 (2011).","journal-title":"Nature"},{"key":"63_CR124","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1172\/JCI88759","volume":"127","author":"V Ramjee","year":"2017","unstructured":"Ramjee, V. et al. Epicardial YAP\/TAZ orchestrate an immunosuppressive response following myocardial infarction. J. Clin. Invest. 127, 899\u2013911 (2017).","journal-title":"J. Clin. Invest."},{"issue":"10","key":"63_CR125","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/s41569-018-0046-4","volume":"15","author":"Jingli Cao","year":"2018","unstructured":"Cao, J. & Poss, K. The epicardium as a hub for heart regeneration. Nat. Rev. Cardiol. https:\/\/doi.org\/10.1038\/s41569-018-0046-4 (2018).","journal-title":"Nature Reviews Cardiology"},{"key":"63_CR126","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrm3416","volume":"13","author":"G Halder","year":"2012","unstructured":"Halder, G., Dupont, S. & Piccolo, S. Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat. Rev. Mol. Cell Biol. 13, 591\u2013600 (2012).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"63_CR127","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2013.07.042","volume":"154","author":"M Aragona","year":"2013","unstructured":"Aragona, M. et al. A mechanical checkpoint controls multicellular growth through YAP\/TAZ regulation by actin-processing factors. Cell 154, 1047\u20131059 (2013).","journal-title":"Cell"},{"key":"63_CR128","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","volume":"474","author":"S Dupont","year":"2011","unstructured":"Dupont, S. et al. Role of YAP\/TAZ in mechanotransduction. Nature 474, 179\u2013183 (2011).","journal-title":"Nature"},{"key":"63_CR129","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1101\/gad.173435.111","volume":"26","author":"B Zhao","year":"2012","unstructured":"Zhao, B. et al. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev. 26, 54\u201368 (2012).","journal-title":"Genes Dev."},{"key":"63_CR130","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1038\/emboj.2011.157","volume":"30","author":"L Sansores-Garcia","year":"2011","unstructured":"Sansores-Garcia, L. et al. Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J. 30, 2325\u20132335 (2011).","journal-title":"EMBO J."},{"key":"63_CR131","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1101\/gad.210773.112","volume":"27","author":"FX Yu","year":"2013","unstructured":"Yu, F. X. & Guan, K. L. The Hippo pathway: regulators and regulations. Genes Dev. 27, 355\u2013371 (2013).","journal-title":"Genes Dev."},{"key":"63_CR132","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1021\/nn4058984","volume":"8","author":"D Mosqueira","year":"2014","unstructured":"Mosqueira, D. et al. Hippo pathway effectors control cardiac progenitor cell fate by acting as dynamic sensors of substrate mechanics and nanostructure. ACS Nano 8, 2033\u20132047 (2014).","journal-title":"ACS Nano"},{"key":"63_CR133","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.stem.2017.11.001","volume":"22","author":"S Yui","year":"2018","unstructured":"Yui, S. et al. YAP\/TAZ-dependent reprogramming of colonic epithelium links ECM remodeling to tissue regeneration. Cell Stem Cell 22, 35\u201349.e7 (2018).","journal-title":"Cell Stem Cell"},{"key":"63_CR134","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature22978","volume":"547","author":"E Bassat","year":"2017","unstructured":"Bassat, E. et al. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature 547, 179\u2013184 (2017).","journal-title":"Nature"},{"key":"63_CR135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature22979","volume":"547","author":"Y Morikawa","year":"2017","unstructured":"Morikawa, Y., Heallen, T., Leach, J., Xiao, Y. & Martin, J. F. Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation. Nature 547, 227\u2013231 (2017).","journal-title":"Nature"},{"key":"63_CR136","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1161\/01.RES.80.1.88","volume":"80","author":"BD Angst","year":"1997","unstructured":"Angst, B. D. et al. Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium. Circ. Res. 80, 88\u201394 (1997).","journal-title":"Circ. Res."},{"key":"63_CR137","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.ydbio.2005.10.046","volume":"289","author":"A Hirschy","year":"2006","unstructured":"Hirschy, A., Schatzmann, F., Ehler, E. & Perriard, J. C. Establishment of cardiac cytoarchitecture in the developing mouse heart. Dev. Biol. 289, 430\u2013441 (2006).","journal-title":"Dev. Biol."},{"key":"63_CR138","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ccell.2016.05.005","volume":"29","author":"F Zanconato","year":"2016","unstructured":"Zanconato, F., Cordenonsi, M. & Piccolo, S. YAP\/TAZ at the roots of cancer. Cancer Cell 29, 783\u2013803 (2016).","journal-title":"Cancer Cell"},{"key":"63_CR139","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1242\/dev.070987","volume":"138","author":"K Wada","year":"2011","unstructured":"Wada, K., Itoga, K., Okano, T., Yonemura, S. & Sasaki, H. Hippo pathway regulation by cell morphology and stress fibers. Development 138, 3907\u20133914 (2011).","journal-title":"Development"},{"key":"63_CR140","doi-asserted-by":"crossref","first-page":"6380","DOI":"10.1128\/MCB.00116-09","volume":"29","author":"RM Densham","year":"2009","unstructured":"Densham, R. M. et al. MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1\/Cip1 stability. Mol. Cell. Biol. 29, 6380\u20136390 (2009).","journal-title":"Mol. Cell. Biol."},{"key":"63_CR141","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1242\/dev.063545","volume":"138","author":"BG Fernandez","year":"2011","unstructured":"Fernandez, B. G. et al. Actin-Capping protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Development 138, 2337\u20132346 (2011).","journal-title":"Development"},{"key":"63_CR142","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/cm.20405","volume":"66","author":"V Gagne","year":"2009","unstructured":"Gagne, V. et al. Human angiomotin-like 1 associates with an angiomotin protein complex through its coiled-coil domain and induces the remodeling of the actin cytoskeleton. Cell. Motil. Cytoskeleton 66, 754\u2013768 (2009).","journal-title":"Cell. Motil. Cytoskeleton"},{"key":"63_CR143","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1242\/dev.127.6.1315","volume":"127","author":"BM McCartney","year":"2000","unstructured":"McCartney, B. M., Kulikauskas, R. M., LaJeunesse, D. R. & Fehon, R. G. The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. Development 127, 1315\u20131324 (2000).","journal-title":"Development"},{"key":"63_CR144","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/HCO.0000000000000050","volume":"29","author":"J Wang","year":"2014","unstructured":"Wang, J. & Martin, J. F. Macro advances in microRNAs and myocardial regeneration. Curr. Opin. Cardiol. 29, 207\u2013213 (2014).","journal-title":"Curr. Opin. Cardiol."},{"key":"63_CR145","doi-asserted-by":"crossref","first-page":"279ra38","DOI":"10.1126\/scitranslmed.3010841","volume":"7","author":"Y Tian","year":"2015","unstructured":"Tian, Y. et al. A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci. Transl Med. 7, 279ra38 (2015).","journal-title":"Sci. Transl Med."},{"key":"63_CR146","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","volume":"22","author":"B Zhao","year":"2008","unstructured":"Zhao, B. et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev. 22, 1962\u20131971 (2008).","journal-title":"Genes Dev."},{"key":"63_CR147","doi-asserted-by":"crossref","first-page":"13355","DOI":"10.1074\/jbc.M900843200","volume":"284","author":"H Zhang","year":"2009","unstructured":"Zhang, H. et al. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J. Biol. Chem. 284, 13355\u201313362 (2009).","journal-title":"J. Biol. Chem."},{"key":"63_CR148","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1158\/0008-5472.CAN-08-2997","volume":"69","author":"B Zhao","year":"2009","unstructured":"Zhao, B., Kim, J., Ye, X., Lai, Z. C. & Guan, K. L. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Cancer Res. 69, 1089\u20131098 (2009).","journal-title":"Cancer Res."},{"key":"63_CR149","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/CIRCRESAHA.115.304457","volume":"116","author":"Z Lin","year":"2015","unstructured":"Lin, Z. et al. Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival. Circ. Res. 116, 35\u201345 (2015).","journal-title":"Circ. Res."},{"key":"63_CR150","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.cell.2011.02.031","volume":"144","author":"K Schlegelmilch","year":"2011","unstructured":"Schlegelmilch, K. et al. Yap1 acts downstream of alpha-catenin to control epidermal proliferation. Cell 144, 782\u2013795 (2011).","journal-title":"Cell"},{"key":"63_CR151","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1101\/gad.262816.115","volume":"29","author":"T Moroishi","year":"2015","unstructured":"Moroishi, T. et al. A YAP\/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 29, 1271\u20131284 (2015).","journal-title":"Genes Dev."},{"key":"63_CR152","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature11693","volume":"493","author":"ER Barry","year":"2013","unstructured":"Barry, E. R. et al. Restriction of intestinal stem cell expansion and the regenerative response by YAP. Nature 493, 106\u2013110 (2013).","journal-title":"Nature"},{"key":"63_CR153","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/emboj.2011.487","volume":"31","author":"M Imajo","year":"2012","unstructured":"Imajo, M., Miyatake, K., Iimura, A., Miyamoto, A. & Nishida, E. A molecular mechanism that links Hippo signalling to the inhibition of Wnt\/beta-catenin signalling. EMBO J. 31, 1109\u20131122 (2012).","journal-title":"EMBO J."},{"key":"63_CR154","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cell.2014.06.013","volume":"158","author":"L Azzolin","year":"2014","unstructured":"Azzolin, L. et al. YAP\/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response. Cell 158, 157\u2013170 (2014).","journal-title":"Cell"},{"key":"63_CR155","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.cell.2012.11.027","volume":"151","author":"L Azzolin","year":"2012","unstructured":"Azzolin, L. et al. Role of TAZ as mediator of Wnt signaling. Cell 151, 1443\u20131456 (2012).","journal-title":"Cell"},{"key":"63_CR156","first-page":"3","volume":"4","author":"G Ozhan","year":"2015","unstructured":"Ozhan, G. & Weidinger, G. Wnt\/beta-catenin signaling in heart regeneration. Cell Regen. (Lond.) 4, 3 (2015).","journal-title":"Cell Regen. (Lond.)"},{"key":"63_CR157","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/ncb3149","volume":"17","author":"G D\u2019Uva","year":"2015","unstructured":"D\u2019Uva, G. et al. ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation. Nat. Cell Biol. 17, 627\u2013638 (2015).","journal-title":"Nat. Cell Biol."},{"key":"63_CR158","doi-asserted-by":"crossref","first-page":"19762","DOI":"10.1073\/pnas.0808393105","volume":"105","author":"LC Zelarayan","year":"2008","unstructured":"Zelarayan, L. C. et al. Beta-catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation. Proc. Natl Acad. Sci. USA 105, 19762\u201319767 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"63_CR159","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1161\/CIRCULATIONAHA.116.024441","volume":"134","author":"D Wo","year":"2016","unstructured":"Wo, D. et al. Opposing roles of Wnt inhibitors IGFBP-4 and Dkk1 in cardiac ischemia by differential targeting of LRP5\/6 and beta-catenin. Circulation 134, 1991\u20132007 (2016).","journal-title":"Circulation"},{"key":"63_CR160","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1101\/gad.307512.117","volume":"31","author":"C Estaras","year":"2017","unstructured":"Estaras, C., Hsu, H. T., Huang, L. & Jones, K. A. YAP repression of the WNT3 gene controls hESC differentiation along the cardiac mesoderm lineage. Genes Dev. 31, 2250\u20132263 (2017).","journal-title":"Genes Dev."},{"key":"63_CR161","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nature15382","volume":"526","author":"A Gregorieff","year":"2015","unstructured":"Gregorieff, A., Liu, Y., Inanlou, M. R., Khomchuk, Y. & Wrana, J. L. Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer. Nature 526, 715\u2013718 (2015).","journal-title":"Nature"}],"container-title":["Nature Reviews Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41569-018-0063-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41569-018-0063-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41569-018-0063-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T18:22:12Z","timestamp":1684606932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41569-018-0063-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,15]]},"references-count":161,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["63"],"URL":"https:\/\/doi.org\/10.1038\/s41569-018-0063-3","relation":{},"ISSN":["1759-5002","1759-5010"],"issn-type":[{"value":"1759-5002","type":"print"},{"value":"1759-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,15]]},"assertion":[{"value":"15 August 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}