{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:13:03Z","timestamp":1793913183950,"version":"4.8.0"},"reference-count":157,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Cardiol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1038\/s41569-024-01110-1","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T19:01:41Z","timestamp":1735758101000},"page":"443-455","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis"],"prefix":"10.1038","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0358-5679","authenticated-orcid":false,"given":"Kajetan","family":"Grodecki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolien","family":"Geers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Kwiecinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3091-3735","authenticated-orcid":false,"given":"Leandro","family":"Slipczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr J.","family":"Slomka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Dweck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitesh","family":"Nerlekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3556-2428","authenticated-orcid":false,"given":"Michelle C.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Berman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Marwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Newby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2236-6970","authenticated-orcid":false,"given":"Damini","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"1110_CR1","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1016\/j.jacc.2022.11.005","volume":"80","author":"M Vaduganathan","year":"2022","unstructured":"Vaduganathan, M., Mensah, G. A., Turco, J. V., Fuster, V. & Roth, G. A. The global burden of cardiovascular diseases and risk. J. Am. Coll. Cardiol. 80, 2361\u20132371 (2022).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR2","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jacc.2021.05.011","volume":"78","author":"B Ibanez","year":"2021","unstructured":"Ibanez, B. et al. Progression of early subclinical atherosclerosis (PESA) study. J. Am. Coll. Cardiol. 78, 156\u2013179 (2021).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR3","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","volume":"5","author":"P Libby","year":"2019","unstructured":"Libby, P. et al. Atherosclerosis. Nat. Rev. Dis. Prim. 5, 56 (2019).","journal-title":"Nat. Rev. Dis. Prim."},{"key":"1110_CR4","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1161\/CIRCULATIONAHA.111.047431","volume":"125","author":"A Arbab-Zadeh","year":"2012","unstructured":"Arbab-Zadeh, A., Nakano, M., Virmani, R. & Fuster, V. Acute coronary events. Circulation 125, 1147\u20131156 (2012).","journal-title":"Circulation"},{"key":"1110_CR5","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1161\/01.CIR.92.3.657","volume":"92","author":"E Falk","year":"1995","unstructured":"Falk, E., Shah, P. K. & Fuster, V. Coronary plaque disruption. Circulation 92, 657\u2013671 (1995).","journal-title":"Circulation"},{"key":"1110_CR6","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1161\/01.CIR.0000135468.67850.F4","volume":"110","author":"JC Wang","year":"2004","unstructured":"Wang, J. C., Normand, S. L., Mauri, L. & Kuntz, R. E. Coronary artery spatial distribution of acute myocardial infarction occlusions. Circulation 110, 278\u2013284 (2004).","journal-title":"Circulation"},{"key":"1110_CR7","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1056\/NEJMoa1002358","volume":"364","author":"GW Stone","year":"2011","unstructured":"Stone, G. W. et al. A prospective natural-history study of coronary atherosclerosis. N. Engl. J. Med. 364, 226\u2013235 (2011).","journal-title":"N. Engl. J. Med."},{"key":"1110_CR8","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.jacc.2013.05.088","volume":"63","author":"R Puri","year":"2014","unstructured":"Puri, R., Nicholls, S. J., Ellis, S. G., Tuzcu, E. M. & Kapadia, S. R. High-risk coronary atheroma: the interplay between ischemia, plaque burden, and disease progression. J. Am. Coll. Cardiol. 63, 1134\u20131140 (2014).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR9","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1161\/CIRCULATIONAHA.119.044720","volume":"141","author":"MC Williams","year":"2020","unstructured":"Williams, M. C. et al. Low-attenuation noncalcified plaque on coronary computed tomography angiography predicts myocardial infarction: results from the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART). Circulation 141, 1452\u20131462 (2020).","journal-title":"Circulation"},{"key":"1110_CR10","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.jacc.2012.10.054","volume":"61","author":"J Narula","year":"2013","unstructured":"Narula, J. et al. Histopathologic characteristics of atherosclerotic coronary disease and implications of the findings for the invasive and noninvasive detection of vulnerable plaques. J. Am. Coll. Cardiol. 61, 1041\u20131051 (2013).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR11","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s12933-024-02368-y","volume":"23","author":"T Zhang","year":"2024","unstructured":"Zhang, T. et al. Longitudinal assessment of coronary plaque regression related to sodium-glucose cotransporter-2 inhibitor using coronary computed tomography angiography. Cardiovasc. Diabetol. 23, 267 (2024).","journal-title":"Cardiovasc. Diabetol."},{"key":"1110_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2023.131330","volume":"392","author":"S Liu","year":"2023","unstructured":"Liu, S. et al. Effect of PCSK9 antibodies on coronary plaque regression and stabilization derived from intravascular imaging in patients with coronary artery disease: a meta-analysis. Int. J. Cardiol. 392, 131330 (2023).","journal-title":"Int. J. Cardiol."},{"key":"1110_CR13","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jcmg.2017.08.013","volume":"11","author":"K Vaidya","year":"2018","unstructured":"Vaidya, K. et al. Colchicine therapy and plaque stabilization in patients with acute coronary syndrome: a CT coronary angiography study. JACC Cardiovasc. Imaging 11, 305\u2013316 (2018).","journal-title":"JACC Cardiovasc. Imaging"},{"key":"1110_CR14","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1001\/jamacardio.2018.1997","volume":"3","author":"M Goeller","year":"2018","unstructured":"Goeller, M. et al. Pericoronary adipose tissue computed tomography attenuation and high-risk plaque characteristics in acute coronary syndrome compared with stable coronary artery disease. JAMA Cardiol. 3, 858\u2013863 (2018).","journal-title":"JAMA Cardiol."},{"key":"1110_CR15","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1016\/j.jcmg.2023.08.021","volume":"16","author":"J Kwiecinski","year":"2023","unstructured":"Kwiecinski, J. et al. Noninvasive coronary atherosclerotic plaque imaging. JACC Cardiovasc. Imaging 16, 1608\u20131622 (2023).","journal-title":"JACC Cardiovasc. Imaging"},{"key":"1110_CR16","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12933-018-0777-x","volume":"17","author":"X-Y Qi","year":"2018","unstructured":"Qi, X.-Y. et al. Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword. Cardiovasc. Diabetol. 17, 134 (2018).","journal-title":"Cardiovasc. Diabetol."},{"key":"1110_CR17","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.jacc.2022.12.021","volume":"81","author":"N Tan","year":"2023","unstructured":"Tan, N., Dey, D., Marwick, T. H. & Nerlekar, N. Pericoronary adipose tissue as a marker of cardiovascular risk. J. Am. Coll. Cardiol. 81, 913\u2013923 (2023).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR18","doi-asserted-by":"publisher","first-page":"4270","DOI":"10.1111\/bph.15634","volume":"178","author":"CP Kotanidis","year":"2021","unstructured":"Kotanidis, C. P. & Antoniades, C. Perivascular fat imaging by computed tomography (CT): a virtual guide. Br. J. Pharmacol. 178, 4270\u20134290 (2021).","journal-title":"Br. J. Pharmacol."},{"key":"1110_CR19","doi-asserted-by":"publisher","first-page":"107459","DOI":"10.1016\/j.carpath.2022.107459","volume":"61","author":"C Hillock-Watling","year":"2022","unstructured":"Hillock-Watling, C. & Gotlieb, A. I. The pathobiology of perivascular adipose tissue (PVAT), the fourth layer of the blood vessel wall. Cardiovasc. Pathol. 61, 107459 (2022).","journal-title":"Cardiovasc. Pathol."},{"key":"1110_CR20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41569-018-0097-6","volume":"16","author":"EK Oikonomou","year":"2019","unstructured":"Oikonomou, E. K. & Antoniades, C. The role of adipose tissue in cardiovascular health and disease. Nat. Rev. Cardiol. 16, 83\u201399 (2019).","journal-title":"Nat. Rev. Cardiol."},{"key":"1110_CR21","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1161\/ATVBAHA.114.303029","volume":"34","author":"NK Brown","year":"2014","unstructured":"Brown, N. K. et al. Perivascular adipose tissue in vascular function and disease: a review of current research and animal models. Arterioscler. Thromb. Vasc. Biol. 34, 1621\u20131630 (2014).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"1110_CR22","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1161\/CIRCRESAHA.121.318093","volume":"128","author":"M Koenen","year":"2021","unstructured":"Koenen, M., Hill, M. A., Cohen, P. & Sowers, J. R. Obesity, adipose tissue and vascular dysfunction. Circ. Res. 128, 951\u2013968 (2021).","journal-title":"Circ. Res."},{"key":"1110_CR23","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.cmet.2010.03.004","volume":"11","author":"A Frontini","year":"2010","unstructured":"Frontini, A. & Cinti, S. Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab. 11, 253\u2013256 (2010).","journal-title":"Cell Metab."},{"key":"1110_CR24","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201600725","volume":"61","author":"A P\u00e9rez-Mart\u00ed","year":"2017","unstructured":"P\u00e9rez-Mart\u00ed, A. et al. A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21). Mol. Nutr. Food Res. 61, 1600725 (2017).","journal-title":"Mol. Nutr. Food Res."},{"key":"1110_CR25","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.3389\/fphys.2018.01781","volume":"9","author":"B Otero-D\u00edaz","year":"2018","unstructured":"Otero-D\u00edaz, B. et al. Exercise induces white adipose tissue browning across the weight spectrum in humans. Front. Physiol. 9, 1781 (2018).","journal-title":"Front. Physiol."},{"key":"1110_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15483-7","volume":"11","author":"FC Lucchini","year":"2020","unstructured":"Lucchini, F. C. et al. ASK1 inhibits browning of white adipose tissue in obesity. Nat. Commun. 11, 1642 (2020).","journal-title":"Nat. Commun."},{"key":"1110_CR27","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.biochi.2017.01.007","volume":"134","author":"AV Kalinovich","year":"2017","unstructured":"Kalinovich, A. V., de Jong, J. M., Cannon, B. & Nedergaard, J. UCP1 in adipose tissues: two steps to full browning. Biochimie 134, 127\u2013137 (2017).","journal-title":"Biochimie"},{"key":"1110_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02158-z","volume":"8","author":"C Fischer","year":"2017","unstructured":"Fischer, C. et al. A miR-327\u2013FGF10\u2013FGFR2-mediated autocrine signaling mechanism controls white fat browning. Nat. Commun. 8, 2079 (2017).","journal-title":"Nat. Commun."},{"key":"1110_CR29","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12986-022-00694-0","volume":"19","author":"SA Machado","year":"2022","unstructured":"Machado, S. A. et al. Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases. Nutr. Metab. 19, 61 (2022).","journal-title":"Nutr. Metab."},{"key":"1110_CR30","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.004200","volume":"1","author":"KA Britton","year":"2012","unstructured":"Britton, K. A. et al. Prevalence, distribution, and risk factor correlates of high thoracic periaortic fat in the Framingham Heart Study. J. Am. Heart Assoc. 1, e004200 (2012).","journal-title":"J. Am. Heart Assoc."},{"key":"1110_CR31","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004545","volume":"6","author":"SR El Khoudary","year":"2017","unstructured":"El Khoudary, S. R. et al. Postmenopausal women with greater paracardial fat have more coronary artery calcification than premenopausal women: the Study of Women\u2019s Health Across the Nation (SWAN) Cardiovascular Fat Ancillary Study. J. Am. Heart Assoc. 6, e004545 (2017).","journal-title":"J. Am. Heart Assoc."},{"key":"1110_CR32","doi-asserted-by":"publisher","first-page":"6623","DOI":"10.1113\/JP274831","volume":"595","author":"AA Ahmad","year":"2017","unstructured":"Ahmad, A. A., Randall, M. D. & Roberts, R. E. Sex differences in the role of phospholipase A(2) \u2014dependent arachidonic acid pathway in the perivascular adipose tissue function in pigs. J. Physiol. 595, 6623\u20136634 (2017).","journal-title":"J. Physiol."},{"key":"1110_CR33","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1161\/HYPERTENSIONAHA.113.02284","volume":"63","author":"D Wang","year":"2014","unstructured":"Wang, D. et al. Endothelial dysfunction and enhanced contractility in microvessels from ovariectomized rats. Hypertension 63, 1063\u20131069 (2014).","journal-title":"Hypertension"},{"key":"1110_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-41341-9","volume":"13","author":"J Yuvaraj","year":"2023","unstructured":"Yuvaraj, J. et al. Pericoronary adipose tissue attenuation on coronary computed tomography angiography associates with male sex and Indigenous Australian status. Sci. Rep. 13, 15509 (2023).","journal-title":"Sci. Rep."},{"key":"1110_CR35","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1007\/s10554-022-02716-7","volume":"38","author":"SE van Rosendael","year":"2022","unstructured":"van Rosendael, S. E. et al. Vessel and sex differences in pericoronary adipose tissue attenuation obtained with coronary CT in individuals without coronary atherosclerosis. Int. J. Cardiovasc. Imaging 38, 2781\u20132789 (2022).","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"1110_CR36","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.123.016178","volume":"17","author":"D Kinoshita","year":"2024","unstructured":"Kinoshita, D. et al. Sex-specific association between perivascular inflammation and plaque vulnerability. Circ. Cardiovasc. Imaging 17, e016178 (2024).","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"1110_CR37","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1097\/MCA.0000000000000178","volume":"25","author":"Y Matsuzawa","year":"2014","unstructured":"Matsuzawa, Y. & Lerman, A. Endothelial dysfunction and coronary artery disease: assessment, prognosis, and treatment. Coron. Artery Dis. 25, 713\u2013724 (2014).","journal-title":"Coron. Artery Dis."},{"key":"1110_CR38","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.7150\/ijbs.7502","volume":"9","author":"P Rajendran","year":"2013","unstructured":"Rajendran, P. et al. The vascular endothelium and human diseases. Int. J. Biol. Sci. 9, 1057\u20131069 (2013).","journal-title":"Int. J. Biol. Sci."},{"key":"1110_CR39","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJM199901143400207","volume":"340","author":"R Ross","year":"1999","unstructured":"Ross, R. Atherosclerosis \u2014 an inflammatory disease. N. Engl. J. Med. 340, 115\u2013126 (1999).","journal-title":"N. Engl. J. Med."},{"key":"1110_CR40","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s10557-018-6820-z","volume":"32","author":"CK Cheng","year":"2018","unstructured":"Cheng, C. K., Bakar, H. A., Gollasch, M. & Huang, Y. Perivascular adipose tissue: the sixth man of the cardiovascular system. Cardiovasc. Drugs Ther. 32, 481\u2013502 (2018).","journal-title":"Cardiovasc. Drugs Ther."},{"key":"1110_CR41","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1093\/cvr\/cvx111","volume":"113","author":"I Akoumianakis","year":"2017","unstructured":"Akoumianakis, I. & Antoniades, C. The interplay between adipose tissue and the cardiovascular system: is fat always bad? Cardiovasc. Res. 113, 999\u20131008 (2017).","journal-title":"Cardiovasc. Res."},{"key":"1110_CR42","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.1111\/bph.13666","volume":"174","author":"I Akoumianakis","year":"2017","unstructured":"Akoumianakis, I., Tarun, A. & Antoniades, C. Perivascular adipose tissue as a regulator of vascular disease pathogenesis: identifying novel therapeutic targets. Br. J. Pharmacol. 174, 3411\u20133424 (2017).","journal-title":"Br. J. Pharmacol."},{"key":"1110_CR43","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.2337\/db14-1011","volume":"64","author":"AS Antonopoulos","year":"2015","unstructured":"Antonopoulos, A. S. et al. Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: the regulatory role of perivascular adipose tissue. Diabetes 64, 2207\u20132219 (2015).","journal-title":"Diabetes"},{"key":"1110_CR44","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","volume":"127","author":"S Mani","year":"2013","unstructured":"Mani, S. et al. Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis. Circulation 127, 2523\u20132534 (2013).","journal-title":"Circulation"},{"key":"1110_CR45","doi-asserted-by":"publisher","first-page":"H1679","DOI":"10.1152\/ajpheart.2000.278.5.H1679","volume":"278","author":"K Kauser","year":"2000","unstructured":"Kauser, K., da Cunha, V., Fitch, R., Mallari, C. & Rubanyi, G. M. Role of endogenous nitric oxide in progression of atherosclerosis in apolipoprotein E-deficient mice. Am. J. Physiol. Heart Circ. Physiol. 278, H1679\u2013H1685 (2000).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"1110_CR46","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1179\/135100009X392566","volume":"14","author":"C Thomas","year":"2009","unstructured":"Thomas, C., Mackey, M. M., Diaz, A. A. & Cox, D. P. Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation. Redox Rep. 14, 102\u2013108 (2009).","journal-title":"Redox Rep."},{"key":"1110_CR47","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1159\/000064521","volume":"39","author":"B Rippe","year":"2002","unstructured":"Rippe, B., Rosengren, B. I., Carlsson, O. & Venturoli, D. Transendothelial transport: the vesicle controversy. J. Vasc. Res. 39, 375\u2013390 (2002).","journal-title":"J. Vasc. Res."},{"key":"1110_CR48","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.atherosclerosis.2020.09.020","volume":"315","author":"E Jang","year":"2020","unstructured":"Jang, E., Robert, J., Rohrer, L., von Eckardstein, A. & Lee, W. L. Transendothelial transport of lipoproteins. Atherosclerosis 315, 111\u2013125 (2020).","journal-title":"Atherosclerosis"},{"key":"1110_CR49","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/ni.2639","volume":"14","author":"FJ Sheedy","year":"2013","unstructured":"Sheedy, F. J. et al. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat. Immunol. 14, 812\u2013820 (2013).","journal-title":"Nat. Immunol."},{"key":"1110_CR50","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S1050-1738(01)00111-6","volume":"11","author":"JL Witztum","year":"2001","unstructured":"Witztum, J. L. & Steinberg, D. The oxidative modification hypothesis of atherosclerosis: does it hold for humans? Trends Cardiovasc. Med. 11, 93\u2013102 (2001).","journal-title":"Trends Cardiovasc. Med."},{"key":"1110_CR51","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/nri2171","volume":"7","author":"JS Pober","year":"2007","unstructured":"Pober, J. S. & Sessa, W. C. Evolving functions of endothelial cells in inflammation. Nat. Rev. Immunol. 7, 803\u2013815 (2007).","journal-title":"Nat. Rev. Immunol."},{"key":"1110_CR52","volume":"141","author":"P Ropraz","year":"2018","unstructured":"Ropraz, P., Imhof, B. A., Matthes, T., Wehrle-Haller, B. & Sidib\u00e9, A. Simultaneous study of the recruitment of monocyte subpopulations under flow in vitro. J. Vis. Exp.\u00a0141, e58509\u00a0(2018).","journal-title":"J. Vis. Exp."},{"key":"1110_CR53","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1093\/cvr\/cvv147","volume":"107","author":"T Gerhardt","year":"2015","unstructured":"Gerhardt, T. & Ley, K. Monocyte trafficking across the vessel wall. Cardiovasc. Res. 107, 321\u2013330 (2015).","journal-title":"Cardiovasc. Res."},{"key":"1110_CR54","doi-asserted-by":"publisher","first-page":"3223","DOI":"10.1161\/CIRCULATIONAHA.108.841130","volume":"119","author":"HY Choi","year":"2009","unstructured":"Choi, H. Y. et al. ATP-binding cassette transporter A1 expression and apolipoprotein A-I binding are impaired in intima-type arterial smooth muscle cells. Circulation 119, 3223\u20133231 (2009).","journal-title":"Circulation"},{"key":"1110_CR55","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1161\/CIRCULATIONAHA.113.005015","volume":"129","author":"S Allahverdian","year":"2014","unstructured":"Allahverdian, S., Chehroudi, A. C., McManus, B. M., Abraham, T. & Francis, G. A. Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis. Circulation 129, 1551\u20131559 (2014).","journal-title":"Circulation"},{"key":"1110_CR56","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1161\/CIRCRESAHA.110.233775","volume":"108","author":"G Chinetti-Gbaguidi","year":"2011","unstructured":"Chinetti-Gbaguidi, G. et al. Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPAR\u03b3 and LXR\u03b1 pathways. Circ. Res. 108, 985\u2013995 (2011).","journal-title":"Circ. Res."},{"key":"1110_CR57","doi-asserted-by":"publisher","first-page":"5989","DOI":"10.1128\/MCB.00541-09","volume":"29","author":"U Maitra","year":"2009","unstructured":"Maitra, U., Parks, J. S. & Li, L. An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2. Mol. Cell Biol. 29, 5989\u20135997 (2009).","journal-title":"Mol. Cell Biol."},{"key":"1110_CR58","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000582","volume":"3","author":"TP Fitzgibbons","year":"2014","unstructured":"Fitzgibbons, T. P. & Czech, M. P. Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations. J. Am. Heart Assoc. 3, e000582 (2014).","journal-title":"J. Am. Heart Assoc."},{"key":"1110_CR59","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.atherosclerosis.2012.08.031","volume":"225","author":"SN Verhagen","year":"2012","unstructured":"Verhagen, S. N., Vink, A., van der Graaf, Y. & Visseren, F. L. Coronary perivascular adipose tissue characteristics are related to atherosclerotic plaque size and composition. A post-mortem study. Atherosclerosis 225, 99\u2013104 (2012).","journal-title":"Atherosclerosis"},{"key":"1110_CR60","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013793","volume":"8","author":"DS Farias-Itao","year":"2019","unstructured":"Farias-Itao, D. S. et al. B lymphocytes and macrophages in the perivascular adipose tissue are associated with coronary atherosclerosis: an autopsy study. J. Am. Heart Assoc. 8, e013793 (2019).","journal-title":"J. Am. Heart Assoc."},{"key":"1110_CR61","doi-asserted-by":"publisher","first-page":"346","DOI":"10.2337\/db11-0860","volume":"61","author":"DY Oh","year":"2012","unstructured":"Oh, D. Y., Morinaga, H., Talukdar, S., Bae, E. J. & Olefsky, J. M. Increased macrophage migration into adipose tissue in obese mice. Diabetes 61, 346\u2013354 (2012).","journal-title":"Diabetes"},{"key":"1110_CR62","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3109\/08916934.2015.1027815","volume":"48","author":"T Shirai","year":"2015","unstructured":"Shirai, T., Hilhorst, M., Harrison, D. G., Goronzy, J. J. & Weyand, C. M. Macrophages in vascular inflammation \u2014 from atherosclerosis to vasculitis. Autoimmunity 48, 139\u2013151 (2015).","journal-title":"Autoimmunity"},{"key":"1110_CR63","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1161\/01.ATV.0000187470.31662.fe","volume":"25","author":"MP Moos","year":"2005","unstructured":"Moos, M. P. et al. The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 25, 2386\u20132391 (2005).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"1110_CR64","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1161\/CIRCRESAHA.115.306427","volume":"118","author":"DF Ketelhuth","year":"2016","unstructured":"Ketelhuth, D. F. & Hansson, G. K. Adaptive response of T and B cells in atherosclerosis. Circ. Res. 118, 668\u2013678 (2016).","journal-title":"Circ. Res."},{"key":"1110_CR65","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1093\/cvr\/cvw186","volume":"111","author":"C Tay","year":"2016","unstructured":"Tay, C. et al. B-cell-specific depletion of tumour necrosis factor alpha inhibits atherosclerosis development and plaque vulnerability to rupture by reducing cell death and inflammation. Cardiovasc. Res. 111, 385\u2013397 (2016).","journal-title":"Cardiovasc. Res."},{"key":"1110_CR66","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1172\/JCI23354","volume":"116","author":"X Du","year":"2006","unstructured":"Du, X. et al. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J. Clin. Invest. 116, 1071\u20131080 (2006).","journal-title":"J. Clin. Invest."},{"key":"1110_CR67","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jtbi.2018.08.010","volume":"456","author":"MG Watson","year":"2018","unstructured":"Watson, M. G., Byrne, H. M., Macaskill, C. & Myerscough, M. R. A two-phase model of early fibrous cap formation in atherosclerosis. J. Theor. Biol. 456, 123\u2013136 (2018).","journal-title":"J. Theor. Biol."},{"key":"1110_CR68","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s12410-011-9090-8","volume":"4","author":"D Chami\u00e9","year":"2011","unstructured":"Chami\u00e9, D., Wang, Z., Bezerra, H., Rollins, A. M. & Costa, M. A. Optical coherence tomography and fibrous cap characterization. Curr. Cardiovasc. Imaging Rep. 4, 276\u2013283 (2011).","journal-title":"Curr. Cardiovasc. Imaging Rep."},{"key":"1110_CR69","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1161\/CIRCRESAHA.115.306361","volume":"118","author":"MR Bennett","year":"2016","unstructured":"Bennett, M. R., Sinha, S. & Owens, G. K. Vascular smooth muscle cells in atherosclerosis. Circ. Res. 118, 692\u2013702 (2016).","journal-title":"Circ. Res."},{"key":"1110_CR70","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1161\/ATVBAHA.114.303983","volume":"34","author":"D Manka","year":"2014","unstructured":"Manka, D. et al. Transplanted perivascular adipose tissue accelerates injury-induced neointimal hyperplasia: role of monocyte chemoattractant protein-1. Arterioscler. Thromb. Vasc. Biol. 34, 1723\u20131730 (2014).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"1110_CR71","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/j.1476-5381.2011.01404.x","volume":"165","author":"CY Miao","year":"2012","unstructured":"Miao, C. Y. & Li, Z. Y. The role of perivascular adipose tissue in vascular smooth muscle cell growth. Br. J. Pharmacol. 165, 643\u2013658 (2012).","journal-title":"Br. J. Pharmacol."},{"key":"1110_CR72","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1161\/01.ATV.20.11.2351","volume":"20","author":"K Miyata","year":"2000","unstructured":"Miyata, K. et al. Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo. Arterioscler. Thromb. Vasc. Biol. 20, 2351\u20132358 (2000).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"1110_CR73","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1172\/JCI118476","volume":"97","author":"H Shimokawa","year":"1996","unstructured":"Shimokawa, H. et al. Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor. J. Clin. Invest. 97, 769\u2013776 (1996).","journal-title":"J. Clin. Invest."},{"key":"1110_CR74","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/276457","volume":"2014","author":"JL Johnson","year":"2014","unstructured":"Johnson, J. L. et al. Relationship of MMP-14 and TIMP-3 expression with macrophage activation and human atherosclerotic plaque vulnerability. Mediators Inflamm. 2014, 276457 (2014).","journal-title":"Mediators Inflamm."},{"key":"1110_CR75","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","volume":"107","author":"F Giacco","year":"2010","unstructured":"Giacco, F. & Brownlee, M. Oxidative stress and diabetic complications. Circ. Res. 107, 1058\u20131070 (2010).","journal-title":"Circ. Res."},{"key":"1110_CR76","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1161\/01.CIR.0000091257.27563.32","volume":"108","author":"MA Creager","year":"2003","unstructured":"Creager, M. A., L\u00fcscher, T. F., Cosentino, F. & Beckman, J. A. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Circulation 108, 1527\u20131532 (2003).","journal-title":"Circulation"},{"key":"1110_CR77","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/s41569-024-01037-7","volume":"21","author":"SS Adkar","year":"2024","unstructured":"Adkar, S. S. & Leeper, N. J. Efferocytosis in atherosclerosis. Nat. Rev. Cardiol. 21, 762\u2013779 (2024).","journal-title":"Nat. Rev. Cardiol."},{"key":"1110_CR78","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1056\/NEJMra1601611","volume":"374","author":"SR Mulay","year":"2016","unstructured":"Mulay, S. R. & Anders, H. J. Crystallopathies. N. Engl. J. Med. 374, 2465\u20132476 (2016).","journal-title":"N. Engl. J. Med."},{"key":"1110_CR79","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/35008121","volume":"404","author":"T Nishikawa","year":"2000","unstructured":"Nishikawa, T. et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404, 787\u2013790 (2000).","journal-title":"Nature"},{"key":"1110_CR80","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s10554-011-9882-6","volume":"28","author":"HM Garc\u00eda-Garc\u00eda","year":"2012","unstructured":"Garc\u00eda-Garc\u00eda, H. M. et al. Relationship between cardiovascular risk factors and biomarkers with necrotic core and atheroma size: a serial intravascular ultrasound radiofrequency data analysis. Int. J. Cardiovasc. Imaging 28, 695\u2013703 (2012).","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"1110_CR81","doi-asserted-by":"publisher","first-page":"C13","DOI":"10.1016\/j.jacc.2005.10.065","volume":"47","author":"R Virmani","year":"2006","unstructured":"Virmani, R., Burke, A. P., Farb, A. & Kolodgie, F. D. Pathology of the vulnerable plaque. J. Am. Coll. Cardiol. 47, C13\u2013C18 (2006).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR82","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0021-9150(91)90235-U","volume":"87","author":"CL Lendon","year":"1991","unstructured":"Lendon, C. L., Davies, M. J., Born, G. V. & Richardson, P. D. Atherosclerotic plaque caps are locally weakened when macrophages density is increased. Atherosclerosis 87, 87\u201390 (1991).","journal-title":"Atherosclerosis"},{"key":"1110_CR83","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007442","volume":"7","author":"Z Xie","year":"2018","unstructured":"Xie, Z. et al. Adipose-derived exosomes exert proatherogenic effects by regulating macrophage foam cell formation and polarization. J. Am. Heart Assoc. 7, e007442 (2018).","journal-title":"J. Am. Heart Assoc."},{"key":"1110_CR84","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1161\/HYPERTENSIONAHA.116.07237","volume":"68","author":"HA Itani","year":"2016","unstructured":"Itani, H. A. et al. Activation of human T cells in hypertension: studies of humanized mice and hypertensive humans. Hypertension 68, 123\u2013132 (2016).","journal-title":"Hypertension"},{"key":"1110_CR85","doi-asserted-by":"publisher","first-page":"E1143","DOI":"10.1073\/pnas.1200498109","volume":"109","author":"L Wu","year":"2012","unstructured":"Wu, L. et al. Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc. Natl Acad. Sci. USA 109, E1143\u2013E1152 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1110_CR86","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1161\/CIRCULATIONAHA.106.638379","volume":"115","author":"H Wu","year":"2007","unstructured":"Wu, H. et al. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 115, 1029\u20131038 (2007).","journal-title":"Circulation"},{"key":"1110_CR87","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1161\/01.ATV.11.5.1223","volume":"11","author":"EP Amento","year":"1991","unstructured":"Amento, E. P., Ehsani, N., Palmer, H. & Libby, P. Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells. Arterioscler. Thromb. 11, 1223\u20131230 (1991).","journal-title":"Arterioscler. Thromb."},{"key":"1110_CR88","first-page":"127","volume":"23","author":"A Yamashita","year":"2008","unstructured":"Yamashita, A. et al. Medial and adventitial macrophages are associated with expansive atherosclerotic remodeling in rabbit femoral artery. Histol. Histopathol. 23, 127\u2013136 (2008).","journal-title":"Histol. Histopathol."},{"key":"1110_CR89","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal2658","volume":"9","author":"AS Antonopoulos","year":"2017","unstructured":"Antonopoulos, A. S. et al. Detecting human coronary inflammation by imaging perivascular fat. Sci. Transl. Med. 9, eaal2658 (2017).","journal-title":"Sci. Transl. Med."},{"key":"1110_CR90","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1093\/cvr\/cvx116","volume":"113","author":"C Antoniades","year":"2017","unstructured":"Antoniades, C. Dysfunctional\u2019 adipose tissue in cardiovascular disease: a reprogrammable target or an innocent bystander? Cardiovasc. Res. 113, 997\u2013998 (2017).","journal-title":"Cardiovasc. Res."},{"key":"1110_CR91","doi-asserted-by":"publisher","first-page":"H295","DOI":"10.1152\/ajpheart.00884.2009","volume":"298","author":"MJ Mulligan-Kehoe","year":"2010","unstructured":"Mulligan-Kehoe, M. J. The vasa vasorum in diseased and nondiseased arteries. Am. J. Physiol. Heart Circ. Physiol. 298, H295\u2013H305 (2010).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"1110_CR92","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1161\/CIRCULATIONAHA.108.821181","volume":"119","author":"AS Greenstein","year":"2009","unstructured":"Greenstein, A. S. et al. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 119, 1661\u20131670 (2009).","journal-title":"Circulation"},{"key":"1110_CR93","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jacc.2013.04.027","volume":"62","author":"R Aghamohammadzadeh","year":"2013","unstructured":"Aghamohammadzadeh, R. et al. Effects of bariatric surgery on human small artery function: evidence for reduction in perivascular adipocyte inflammation, and the restoration of normal anticontractile activity despite persistent obesity. J. Am. Coll. Cardiol. 62, 128\u2013135 (2013).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR94","doi-asserted-by":"publisher","first-page":"3335","DOI":"10.1161\/01.CIR.0000147825.97879.E7","volume":"110","author":"P Calabro","year":"2004","unstructured":"Calabro, P., Samudio, I., Willerson, J. T. & Yeh, E. T. Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1\/2 and phosphatidylinositol 3-kinase pathways. Circulation 110, 3335\u20133340 (2004).","journal-title":"Circulation"},{"key":"1110_CR95","doi-asserted-by":"publisher","first-page":"H193","DOI":"10.1152\/ajpheart.00431.2009","volume":"299","author":"C Chen","year":"2010","unstructured":"Chen, C. et al. Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 299, H193\u2013H201 (2010).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"1110_CR96","doi-asserted-by":"publisher","first-page":"E205","DOI":"10.1152\/ajpendo.00053.2015","volume":"309","author":"RW Grant","year":"2015","unstructured":"Grant, R. W. & Stephens, J. M. Fat in flames: influence of cytokines and pattern recognition receptors on adipocyte lipolysis. Am. J. Physiol. Endocrinol. Metab. 309, E205\u2013E213 (2015).","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"1110_CR97","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.bbrc.2003.12.104","volume":"314","author":"D Kawanami","year":"2004","unstructured":"Kawanami, D. et al. Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. Biochem. Biophys. Res. Commun. 314, 415\u2013419 (2004).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"1110_CR98","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021003","volume":"10","author":"T McLaughlin","year":"2021","unstructured":"McLaughlin, T. et al. Relationship between coronary atheroma, epicardial adipose tissue inflammation, and adipocyte differentiation across the human myocardial bridge. J. Am. Heart Assoc. 10, e021003 (2021).","journal-title":"J. Am. Heart Assoc."},{"key":"1110_CR99","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1161\/ATVBAHA.117.309843","volume":"37","author":"K Ohyama","year":"2017","unstructured":"Ohyama, K. et al. Association of coronary perivascular adipose tissue inflammation and drug-eluting stent-induced coronary hyperconstricting responses in pigs: 18F-fluorodeoxyglucose positron emission tomography imaging study. Arterioscler. Thromb. Vasc. Biol. 37, 1757\u20131764 (2017).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"1110_CR100","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1161\/ATVBAHA.110.207175","volume":"30","author":"M Takaoka","year":"2010","unstructured":"Takaoka, M. et al. Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue. Arterioscler. Thromb. Vasc. Biol. 30, 1576\u20131582 (2010).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"1110_CR101","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1161\/ATVBAHA.120.312470","volume":"40","author":"HW Kim","year":"2020","unstructured":"Kim, H. W., Shi, H., Winkler, M. A., Lee, R. & Weintraub, N. L. Perivascular adipose tissue and vascular perturbation\/atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 40, 2569\u20132576 (2020).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"1110_CR102","doi-asserted-by":"publisher","first-page":"6129","DOI":"10.1007\/s00330-019-06219-3","volume":"29","author":"H Matsumoto","year":"2019","unstructured":"Matsumoto, H. et al. Standardized volumetric plaque quantification and characterization from coronary CT angiography: a head-to-head comparison with invasive intravascular ultrasound. Eur. Radiol. 29, 6129\u20136139 (2019).","journal-title":"Eur. Radiol."},{"key":"1110_CR103","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1093\/eurheartj\/ehx774","volume":"39","author":"I Cho","year":"2018","unstructured":"Cho, I. et al. Prognostic value of coronary computed tomographic angiography findings in asymptomatic individuals: a 6-year follow-up from the prospective multicentre international CONFIRM study. Eur. Heart J. 39, 934\u2013941 (2018).","journal-title":"Eur. Heart J."},{"key":"1110_CR104","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1093\/cvr\/cvz321","volume":"116","author":"F Commandeur","year":"2020","unstructured":"Commandeur, F. et al. Machine learning to predict the long-term risk of myocardial infarction and cardiac death based on clinical risk, coronary calcium, and epicardial adipose tissue: a prospective study. Cardiovasc. Res. 116, 2216\u20132225 (2020).","journal-title":"Cardiovasc. Res."},{"key":"1110_CR105","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.atherosclerosis.2020.07.011","volume":"309","author":"D Han","year":"2020","unstructured":"Han, D. et al. Prognostic significance of subtle coronary calcification in patients with zero coronary artery calcium score: from the CONFIRM registry. Atherosclerosis 309, 33\u201338 (2020).","journal-title":"Atherosclerosis"},{"key":"1110_CR106","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1093\/ehjci\/jeab135","volume":"23","author":"M Osborne-Grinter","year":"2022","unstructured":"Osborne-Grinter, M. et al. Association of coronary artery calcium score with qualitatively and quantitatively assessed adverse plaque on coronary CT angiography in the SCOT-HEART trial. Eur. Heart J. Cardiovasc. Imaging 23, 1210\u20131221 (2022).","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"1110_CR107","doi-asserted-by":"publisher","first-page":"umae007","DOI":"10.1093\/radadv\/umae007","volume":"1","author":"S Kato","year":"2024","unstructured":"Kato, S., Azuma, M., Horita, N. & Utsunomiya, D. Prognostic significance of CAD-RADS for patients with suspected coronary artery disease: a systematic review and meta-analysis. Radiol. Adv. 1, umae007 (2024).","journal-title":"Radiol. Adv."},{"key":"1110_CR108","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.jcct.2023.08.009","volume":"17","author":"E Maclean","year":"2023","unstructured":"Maclean, E., Cronshaw, R., Newby, D. E., Nicol, E. & Williams, M. C. Prognostic utility of semi-quantitative coronary computed tomography angiography scores in the SCOT-HEART trial. J. Cardiovasc. Comput. Tomogr. 17, 393\u2013400 (2023).","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"1110_CR109","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.jacc.2007.03.044","volume":"50","author":"S Motoyama","year":"2007","unstructured":"Motoyama, S. et al. Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes. J. Am. Coll. Cardiol. 50, 319\u2013326 (2007).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR110","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jacc.2018.10.066","volume":"73","author":"MC Williams","year":"2019","unstructured":"Williams, M. C. et al. Coronary artery plaque characteristics associated with adverse outcomes in the SCOT-HEART study. J. Am. Coll. Cardiol. 73, 291\u2013301 (2019).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR111","doi-asserted-by":"publisher","DOI":"10.1148\/ryct.230090","volume":"5","author":"H Tanisawa","year":"2023","unstructured":"Tanisawa, H. et al. Quantification of low-attenuation plaque burden from coronary CT angiography: a head-to-head comparison with near-infrared spectroscopy intravascular US. Radiol. Cardiothorac. Imaging 5, e230090 (2023).","journal-title":"Radiol. Cardiothorac. Imaging"},{"key":"1110_CR112","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1016\/j.jacc.2018.02.079","volume":"71","author":"HJ Chang","year":"2018","unstructured":"Chang, H. J. et al. Coronary atherosclerotic precursors of acute coronary syndromes. J. Am. Coll. Cardiol. 71, 2511\u20132522 (2018).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR113","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1016\/j.jcmg.2021.03.004","volume":"14","author":"MC Williams","year":"2021","unstructured":"Williams, M. C. et al. Sex-specific computed tomography coronary plaque characterization and risk of myocardial infarction. JACC Cardiovasc. Imaging 14, 1804\u20131814 (2021).","journal-title":"JACC Cardiovasc. Imaging"},{"key":"1110_CR114","doi-asserted-by":"publisher","first-page":"e256","DOI":"10.1016\/S2589-7500(22)00022-X","volume":"4","author":"A Lin","year":"2022","unstructured":"Lin, A. et al. Deep learning-enabled coronary CT angiography for plaque and stenosis quantification and cardiac risk prediction: an international multicentre study. Lancet Digit. Health 4, e256\u2013e265 (2022).","journal-title":"Lancet Digit. Health"},{"key":"1110_CR115","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jacc.2015.05.069","volume":"66","author":"S Motoyama","year":"2015","unstructured":"Motoyama, S. et al. Plaque characterization by coronary computed tomography angiography and the likelihood of acute coronary events in mid-term follow-up. J. Am. Coll. Cardiol. 66, 337\u2013346 (2015).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR116","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jcct.2020.03.007","volume":"15","author":"E Tzolos","year":"2021","unstructured":"Tzolos, E. et al. Repeatability of quantitative pericoronary adipose tissue attenuation and coronary plaque burden from coronary CT angiography. J. Cardiovasc. Comput. Tomogr. 15, 81\u201384 (2021).","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"1110_CR117","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.21037\/qims-20-860","volume":"11","author":"X Chen","year":"2021","unstructured":"Chen, X. et al. Pericoronary adipose tissue attenuation assessed by dual-layer spectral detector computed tomography is a sensitive imaging marker of high-risk plaques. Quant. Imaging Med. Surg. 11, 2093\u20132103 (2021).","journal-title":"Quant. Imaging Med. Surg."},{"key":"1110_CR118","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.jacc.2022.12.021","volume":"81","author":"N Tan","year":"2023","unstructured":"Tan, N., Dey, D., Marwick, T. H. & Nerlekar, N. Pericoronary adipose tissue as a marker of cardiovascular risk: JACC review topic of the week. J. Am. Coll. Cardiol. 81, 913\u2013923 (2023).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR119","doi-asserted-by":"publisher","first-page":"6838","DOI":"10.1007\/s00330-020-07069-0","volume":"30","author":"R Ma","year":"2020","unstructured":"Ma, R. et al. Towards reference values of pericoronary adipose tissue attenuation: impact of coronary artery and tube voltage in coronary computed tomography angiography. Eur. Radiol. 30, 6838\u20136846 (2020).","journal-title":"Eur. Radiol."},{"key":"1110_CR120","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/S0140-6736(18)31114-0","volume":"392","author":"EK Oikonomou","year":"2018","unstructured":"Oikonomou, E. K. et al. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. Lancet 392, 929\u2013939 (2018).","journal-title":"Lancet"},{"key":"1110_CR121","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.jcmg.2022.02.004","volume":"15","author":"E Tzolos","year":"2022","unstructured":"Tzolos, E. et al. Pericoronary adipose tissue attenuation, low-attenuation plaque burden, and 5-year risk of myocardial infarction. JACC Cardiovasc. Imaging 15, 1078\u20131088 (2022).","journal-title":"JACC Cardiovasc. Imaging"},{"key":"1110_CR122","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1016\/S0140-6736(24)00596-8","volume":"403","author":"K Chan","year":"2024","unstructured":"Chan, K. et al. Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study. Lancet 403, 2606\u20132618 (2024).","journal-title":"Lancet"},{"key":"1110_CR123","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s12410-015-9340-2","volume":"8","author":"WJ Stuijfzand","year":"2015","unstructured":"Stuijfzand, W. J. et al. Value of hybrid imaging with PET\/CT to guide percutaneous revascularization of chronic total coronary occlusion. Curr. Cardiovasc. Imaging Rep. 8, 26 (2015).","journal-title":"Curr. Cardiovasc. Imaging Rep."},{"key":"1110_CR124","doi-asserted-by":"publisher","first-page":"6028","DOI":"10.1007\/s00330-022-08781-9","volume":"32","author":"W Bao","year":"2022","unstructured":"Bao, W. et al. A preliminary coronary computed tomography angiography-based study of perivascular fat attenuation index: relation with epicardial adipose tissue and its distribution over the entire coronary vasculature. Eur. Radiol. 32, 6028\u20136036 (2022).","journal-title":"Eur. Radiol."},{"key":"1110_CR125","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1093\/ehjci\/jez013","volume":"20","author":"M Goeller","year":"2019","unstructured":"Goeller, M. et al. Relationship between changes in pericoronary adipose tissue attenuation and coronary plaque burden quantified from coronary computed tomography angiography. Eur. Heart J. Cardiovasc. Imaging 20, 636\u2013643 (2019).","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"1110_CR126","doi-asserted-by":"publisher","first-page":"3529","DOI":"10.1093\/eurheartj\/ehz592","volume":"40","author":"EK Oikonomou","year":"2019","unstructured":"Oikonomou, E. K. et al. A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography. Eur. Heart J. 40, 3529\u20133543 (2019).","journal-title":"Eur. Heart J."},{"key":"1110_CR127","first-page":"2677","volume":"117","author":"EK Oikonomou","year":"2021","unstructured":"Oikonomou, E. K. et al. Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device. Cardiovasc. Res. 117, 2677\u20132690 (2021).","journal-title":"Cardiovasc. Res."},{"key":"1110_CR128","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1016\/j.jcmg.2020.06.033","volume":"13","author":"A Lin","year":"2020","unstructured":"Lin, A. et al. Myocardial infarction associates with a distinct pericoronary adipose tissue radiomic phenotype: a prospective case-control study. JACC Cardiovasc. Imaging 13, 2371\u20132383 (2020).","journal-title":"JACC Cardiovasc. Imaging"},{"key":"1110_CR129","doi-asserted-by":"publisher","first-page":"e705","DOI":"10.1016\/S2589-7500(22)00132-7","volume":"4","author":"CP Kotanidis","year":"2022","unstructured":"Kotanidis, C. P. et al. Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19. Lancet Digit. Health 4, e705\u2013e716 (2022).","journal-title":"Lancet Digit. Health"},{"key":"1110_CR130","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1161\/ATVBAHA.121.315969","volume":"41","author":"AJ Buckler","year":"2021","unstructured":"Buckler, A. J. et al. Virtual transcriptomics: noninvasive phenotyping of atherosclerosis by decoding plaque biology from computed tomography angiography imaging. Arterioscler. Thromb. Vasc. Biol. 41, 1738\u20131750 (2021).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"1110_CR131","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.atherosclerosis.2016.05.033","volume":"251","author":"MT Lu","year":"2016","unstructured":"Lu, M. T. et al. Epicardial and paracardial adipose tissue volume and attenuation \u2014 association with high-risk coronary plaque on computed tomographic angiography in the ROMICAT II trial. Atherosclerosis 251, 47\u201354 (2016).","journal-title":"Atherosclerosis"},{"key":"1110_CR132","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s00380-017-0943-1","volume":"32","author":"R Okubo","year":"2017","unstructured":"Okubo, R. et al. Pericoronary adipose tissue ratio is a stronger associated factor of plaque vulnerability than epicardial adipose tissue on coronary computed tomography angiography. Heart Vessel. 32, 813\u2013822 (2017).","journal-title":"Heart Vessel."},{"key":"1110_CR133","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1016\/j.jcmg.2018.11.032","volume":"12","author":"J Kwiecinski","year":"2019","unstructured":"Kwiecinski, J. et al. Peri-coronary adipose tissue density is associated with 18F-sodium fluoride coronary uptake in stable patients with high-risk plaques. JACC Cardiovasc. Imaging 12, 2000\u20132010 (2019).","journal-title":"JACC Cardiovasc. Imaging"},{"key":"1110_CR134","doi-asserted-by":"publisher","DOI":"10.1093\/ehjopen\/oeab019","volume":"1","author":"C Wall","year":"2021","unstructured":"Wall, C. et al. Pericoronary and periaortic adipose tissue density are associated with inflammatory disease activity in Takayasu arteritis and atherosclerosis. Eur. Heart J. Open 1, oeab019 (2021).","journal-title":"Eur. Heart J. Open"},{"key":"1110_CR135","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/ehjci\/jeaa224","volume":"22","author":"A Lin","year":"2021","unstructured":"Lin, A. et al. Pericoronary adipose tissue computed tomography attenuation distinguishes different stages of coronary artery disease: a cross-sectional study. Eur. Heart J. Cardiovasc. Imaging 22, 298\u2013306 (2021).","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"1110_CR136","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3390\/cells10051143","volume":"10","author":"J Yuvaraj","year":"2021","unstructured":"Yuvaraj, J. et al. Pericoronary adipose tissue attenuation is associated with high-risk plaque and subsequent acute coronary syndrome in patients with stable coronary artery disease. Cells 10, 1143 (2021).","journal-title":"Cells"},{"key":"1110_CR137","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jcct.2021.03.005","volume":"15","author":"M Goeller","year":"2021","unstructured":"Goeller, M. et al. Pericoronary adipose tissue CT attenuation and its association with serum levels of atherosclerosis-relevant inflammatory mediators, coronary calcification and major adverse cardiac events. J. Cardiovasc. Comput. Tomogr. 15, 449\u2013454 (2021).","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"1110_CR138","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1093\/ehjci\/jeae197","volume":"25","author":"SE van Rosendael","year":"2024","unstructured":"van Rosendael, S. E. et al. Pericoronary adipose tissue for predicting long-term outcome. Eur. Heart J. Cardiovasc. Imaging 25, 1351\u20131359 (2024).","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"1110_CR139","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/s41569-023-00880-4","volume":"20","author":"AJV M\u00e9zquita","year":"2023","unstructured":"M\u00e9zquita, A. J. V. et al. Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a consensus statement from the Quantitative Cardiovascular Imaging Study Group. Nat. Rev. Cardiol. 20, 696\u2013714 (2023).","journal-title":"Nat. Rev. Cardiol."},{"key":"1110_CR140","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jcmg.2017.10.012","volume":"11","author":"H Mori","year":"2018","unstructured":"Mori, H. et al. Coronary artery calcification and its progression: what does it really mean? JACC Cardiovasc. Imaging 11, 127\u2013142 (2018).","journal-title":"JACC Cardiovasc. Imaging"},{"key":"1110_CR141","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1001\/jamacardio.2019.5315","volume":"5","author":"AR van Rosendael","year":"2020","unstructured":"van Rosendael, A. R. et al. Association of high-density calcified 1K plaque with risk of acute coronary syndrome. JAMA Cardiol. 5, 282\u2013290 (2020).","journal-title":"JAMA Cardiol."},{"key":"1110_CR142","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.tcm.2023.07.002","volume":"34","author":"J Aldana-Bitar","year":"2023","unstructured":"Aldana-Bitar, J., Bhatt, D. L. & Budoff, M. J. Regression and stabilization of atherogenic plaques. Trends Cardiovasc. Med. 34, 340\u2013346 (2023).","journal-title":"Trends Cardiovasc. Med."},{"key":"1110_CR143","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1016\/j.jcmg.2018.04.015","volume":"11","author":"SE Lee","year":"2018","unstructured":"Lee, S. E. et al. Effects of statins on coronary atherosclerotic plaques: the PARADIGM study. JACC Cardiovasc. Imaging 11, 1475\u20131484 (2018).","journal-title":"JACC Cardiovasc. Imaging"},{"key":"1110_CR144","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1093\/ehjci\/jey012","volume":"19","author":"L Andelius","year":"2018","unstructured":"Andelius, L., Mortensen, M. B., N\u00f8rgaard, B. L. & Abdulla, J. Impact of statin therapy on coronary plaque burden and composition assessed by coronary computed tomographic angiography: a systematic review and meta-analysis. Eur. Heart J. Cardiovasc. Imaging 19, 850\u2013858 (2018).","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"1110_CR145","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.jcmg.2016.04.013","volume":"10","author":"S Shin","year":"2017","unstructured":"Shin, S. et al. Impact of intensive LDL cholesterol lowering on coronary artery atherosclerosis progression: a serial CT angiography study. JACC Cardiovasc. Imaging 10, 437\u2013446 (2017).","journal-title":"JACC Cardiovasc. Imaging"},{"key":"1110_CR146","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.jacc.2015.05.065","volume":"66","author":"K Tsujita","year":"2015","unstructured":"Tsujita, K. et al. Impact of dual lipid-lowering strategy with ezetimibe and atorvastatin on coronary plaque regression in patients with percutaneous coronary intervention: the Multicenter Randomized Controlled PRECISE-IVUS trial. J. Am. Coll. Cardiol. 66, 495\u2013507 (2015).","journal-title":"J. Am. Coll. Cardiol."},{"key":"1110_CR147","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1161\/CIRCULATIONAHA.122.062557","volume":"147","author":"L P\u00e9rez de Isla","year":"2023","unstructured":"P\u00e9rez de Isla, L. et al. Alirocumab and coronary atherosclerosis in asymptomatic patients with familial hypercholesterolemia: the ARCHITECT study. Circulation 147, 1436\u20131443 (2023).","journal-title":"Circulation"},{"key":"1110_CR148","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.ijcard.2020.06.008","volume":"319","author":"X Dai","year":"2020","unstructured":"Dai, X. et al. Serial change of perivascular fat attenuation index after statin treatment: insights from a coronary CT angiography follow-up study. Int. J. Cardiol. 319, 144\u2013149 (2020).","journal-title":"Int. J. Cardiol."},{"key":"1110_CR149","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1001\/jamacardio.2019.2589","volume":"4","author":"YA Elnabawi","year":"2019","unstructured":"Elnabawi, Y. A. et al. Association of biologic therapy with coronary inflammation in patients with psoriasis as assessed by perivascular fat attenuation index. JAMA Cardiol. 4, 885\u2013891 (2019).","journal-title":"JAMA Cardiol."},{"key":"1110_CR150","doi-asserted-by":"publisher","first-page":"438","DOI":"10.7326\/0003-4819-156-6-201203200-00006","volume":"156","author":"M Kavousi","year":"2012","unstructured":"Kavousi, M. et al. Evaluation of newer risk markers for coronary heart disease risk classification: a cohort study. Ann. Intern. Med. 156, 438\u2013444 (2012).","journal-title":"Ann. Intern. Med."},{"key":"1110_CR151","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1161\/CIRCULATIONAHA.123.067626","volume":"149","author":"SS Khan","year":"2024","unstructured":"Khan, S. S. et al. Development and validation of the American Heart Association\u2019s PREVENT equations. Circulation 149, 430\u2013449 (2024).","journal-title":"Circulation"},{"key":"1110_CR152","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1136\/bmj.38985.646481.55","volume":"333","author":"KA Fox","year":"2006","unstructured":"Fox, K. A. et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). BMJ 333, 1091 (2006).","journal-title":"BMJ"},{"key":"1110_CR153","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12933-023-01857-w","volume":"22","author":"M-M Yu","year":"2023","unstructured":"Yu, M.-M. et al. Evolocumab attenuate pericoronary adipose tissue density via reduction of lipoprotein(a) in type 2 diabetes mellitus: a serial follow-up CCTA study. Cardiovasc. Diabetol. 22, 121 (2023).","journal-title":"Cardiovasc. Diabetol."},{"key":"1110_CR154","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.jcct.2022.05.004","volume":"16","author":"D Chatterjee","year":"2022","unstructured":"Chatterjee, D. et al. Perivascular fat attenuation for predicting adverse cardiac events in stable patients undergoing invasive coronary angiography. J. Cardiovasc. Comput. Tomogr. 16, 483\u2013490 (2022).","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"1110_CR155","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1161\/CIRCIMAGING.122.015120","volume":"16","author":"D Wen","year":"2023","unstructured":"Wen, D. et al. Lack of incremental prognostic value of pericoronary adipose tissue computed tomography attenuation beyond coronary artery disease reporting and data system for major adverse cardiovascular events in patients with acute chest pain. Circ. Cardiovasc. Imaging 16, 536\u2013544 (2023).","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"1110_CR156","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1093\/bjr\/tqad017","volume":"97","author":"M Chen","year":"2024","unstructured":"Chen, M. et al. Lesion-specific pericoronary adipose tissue CT attenuation improves risk prediction of major adverse cardiovascular events in coronary artery disease. Br. J. Radiol. 97, 258\u2013266 (2024).","journal-title":"Br. J. Radiol."},{"key":"1110_CR157","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1016\/j.acra.2023.12.001","volume":"31","author":"W Yang","year":"2024","unstructured":"Yang, W. et al. Prognostic value of non-alcoholic fatty liver disease and RCA pericoronary adipose tissue CT attenuation in patients with acute chest pain. Acad. Radiol. 31, 1773\u20131783 (2024).","journal-title":"Acad. Radiol."}],"container-title":["Nature Reviews Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41569-024-01110-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41569-024-01110-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41569-024-01110-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T08:02:10Z","timestamp":1747728130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41569-024-01110-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,2]]},"references-count":157,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["1110"],"URL":"https:\/\/doi.org\/10.1038\/s41569-024-01110-1","relation":{},"ISSN":["1759-5002","1759-5010"],"issn-type":[{"value":"1759-5002","type":"print"},{"value":"1759-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,2]]},"assertion":[{"value":"20 November 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"P.J.S., D.B. and D.D. may receive royalties from Cedars-Sinai Medical Center and have equity in APQ Health. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}