{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:10:39Z","timestamp":1791267039975,"version":"4.1.0"},"reference-count":108,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Chem"],"DOI":"10.1038\/s41570-021-00345-7","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T12:02:48Z","timestamp":1642161768000},"page":"170-181","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Natural product anticipation through synthesis"],"prefix":"10.1038","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0372-9126","authenticated-orcid":false,"given":"Belinda E.","family":"Hetzler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-6056","authenticated-orcid":false,"given":"Dirk","family":"Trauner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9573-5637","authenticated-orcid":false,"given":"Andrew L.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,14]]},"reference":[{"key":"345_CR1","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1002\/anie.200460864","volume":"44","author":"KC Nicolaou","year":"2005","unstructured":"Nicolaou, K. C. & Snyder, S. A. Chasing molecules that were never there: misassigned natural products and the role of chemical synthesis in modern structure elucidation. Angew. Chem. Int. Ed. 44, 1012\u20131044 (2005).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR2","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1039\/C7NP00025A","volume":"34","author":"PD Brown","year":"2017","unstructured":"Brown, P. D. & Lawrence, A. L. The importance of asking \u201chow and why?\u201d in natural product structure elucidation. Nat. Prod. Rep. 34, 1193\u20131202 (2017).","journal-title":"Nat. Prod. Rep."},{"key":"345_CR3","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1021\/ja01562a063","volume":"79","author":"JC Sheehan","year":"1957","unstructured":"Sheehan, J. C. & Henery-Logan, K. R. The total synthesis of penicillin V. J. Am. Chem. Soc. 79, 1262\u20131263 (1957).","journal-title":"J. Am. Chem. Soc."},{"key":"345_CR4","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1039\/C3NP70090A","volume":"31","author":"CA Kuttruff","year":"2014","unstructured":"Kuttruff, C. A., Eastgate, M. D. & Baran, P. S. Natural product synthesis in the age of scalability. Nat. Prod. Rep. 31, 419\u2013432 (2014).","journal-title":"Nat. Prod. Rep."},{"key":"345_CR5","doi-asserted-by":"publisher","first-page":"4751","DOI":"10.1021\/jacs.8b02266","volume":"140","author":"PS Baran","year":"2018","unstructured":"Baran, P. S. Natural product total synthesis: as exciting as ever and here to stay. J. Am. Chem. Soc. 140, 4751\u20134755 (2018).","journal-title":"J. Am. Chem. Soc."},{"key":"345_CR6","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1039\/c4np90008a","volume":"31","author":"D Trauner","year":"2014","unstructured":"Trauner, D. Finding function and form. Nat. Prod. Rep. 31, 411\u2013413 (2014).","journal-title":"Nat. Prod. Rep."},{"key":"345_CR7","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1002\/cber.189302602204","volume":"26","author":"S Gabriel","year":"1893","unstructured":"Gabriel, S. & Pinkus, G. Zur Kenntniss der Amidoketone. Ber. Dtsch. Chem. Ges. 26, 2197\u20132209 (1893).","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"345_CR8","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1002\/cber.190203503214","volume":"35","author":"S Gabriel","year":"1902","unstructured":"Gabriel, S. & Colman, J. Zur Kenntniss des Amidoacetons. Ber. Dtsch. Chem. Ges. 35, 3805\u20133811 (1902).","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"345_CR9","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/1831051a0","volume":"183","author":"WH Elliott","year":"1959","unstructured":"Elliott, W. H. Amino-acetone: its isolation and role in metabolism. Nature 183, 1051\u20131052 (1959).","journal-title":"Nature"},{"key":"345_CR10","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1002\/cber.190003301201","volume":"33","author":"R Willst\u00e4tter","year":"1900","unstructured":"Willst\u00e4tter, R. Synthese der Hygrins\u00e4ure. Ber. Dtsch. Chem. Ges. 33, 1160\u20131166 (1900).","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"345_CR11","first-page":"81","volume":"39","author":"E Fischer","year":"1903","unstructured":"Fischer, E. & Abderhalden, E. Ober die verdauung einiger Eiwei\u00dfk\u00f6rper durch Pankreasfermente. Biol. Chem. 39, 81\u201394 (1903).","journal-title":"Biol. Chem."},{"key":"345_CR12","unstructured":"Willst\u00e4tter, R. From My Life: The Memoirs of Richard Willst\u00e4tter (Plunkett Lake, 2016)."},{"key":"345_CR13","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1002\/hlca.19750580815","volume":"58","author":"H Falk","year":"1975","unstructured":"Falk, H., Hoornaert, G., Isenring, H.-P. & Eschenmoser, A. \u00dcber Enolderivate der Chlorophyllreihe. Darstellung von 132,173-Cycloph\u00e4ophorbid-enolen. Vorl\u00e4ufige Mitteilung. Helv. Chim. Acta 58, 2347\u20132357 (1975).","journal-title":"Helv. Chim. Acta"},{"key":"345_CR14","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1016\/S0040-4039(00)84480-9","volume":"27","author":"P Karuso","year":"1986","unstructured":"Karuso, P. et al. 132,173-Cyclopheophorbide enol, the first porphyrin isolated from a sponge. Tetrahedron Lett. 27, 2177\u20132178 (1986).","journal-title":"Tetrahedron Lett."},{"key":"345_CR15","doi-asserted-by":"publisher","first-page":"3743","DOI":"10.1016\/S0016-7037(99)00168-4","volume":"63","author":"R Ocampo","year":"1999","unstructured":"Ocampo, R., Sachs, J. P. & Repeta, D. J. Isolation and structure determination of the unstable 132, 173-Cyclopheophorbide a enol from recent sediments. Geochim. Cosmochim. Acta 63, 3743\u20133749 (1999).","journal-title":"Geochim. Cosmochim. Acta"},{"key":"345_CR16","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0040-4039(01)90620-3","volume":"4","author":"RA Bell","year":"1963","unstructured":"Bell, R. A. & Ireland, R. E. The construction of the C\/D ring system present in the diterpenoid alkaloids atisine and garryfoline. Tetrahedron Lett. 4, 269\u2013273 (1963).","journal-title":"Tetrahedron Lett."},{"key":"345_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0040-4039(01)99337-2","volume":"1","author":"RF Church","year":"1960","unstructured":"Church, R. F., Ireland, R. E. & Marshall, J. A. The stereospecific total synthesis of d1-8\u03b2-carbomethoxy-13-oxopodocarpane, a degradation product of phyllocladene. Tetrahedron Lett. 1, 1\u20134 (1960).","journal-title":"Tetrahedron Lett."},{"key":"345_CR18","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1021\/jo01043a022","volume":"28","author":"LH Zalkow","year":"1963","unstructured":"Zalkow, L. H. & Girotra, N. N. The synthesis of 5a,8,8-trimethyl-3, 10a-ethanoperhydrophenanthrene. Terpenes. VII. J. Org. Chem. 28, 2037\u20132039 (1963).","journal-title":"J. Org. Chem."},{"key":"345_CR19","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1021\/jo01029a006","volume":"29","author":"LH Zalkow","year":"1964","unstructured":"Zalkow, L. H. & Girotra, N. N. Studies in the synthesis of atisine. Terpenes. X. J. Org. Chem. 29, 1299\u20131302 (1964).","journal-title":"J. Org. Chem."},{"key":"345_CR20","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1016\/S0040-4039(01)99533-4","volume":"6","author":"AH Kapadi","year":"1965","unstructured":"Kapadi, A. H., Sobti, R. R. & Dev, S. The diterpenoids of Erythroxylon monogynum \u2014 V atisirene, isoatisirene and devadarene. Tetrahedron Lett. 6, 2729\u20132735 (1965).","journal-title":"Tetrahedron Lett."},{"key":"345_CR21","doi-asserted-by":"publisher","first-page":"14454","DOI":"10.1002\/chem.201702336","volume":"23","author":"N Bonneau","year":"2017","unstructured":"Bonneau, N. et al. An unprecedented blue chromophore found in nature using a \u201cchemistry first\u201d and molecular networking approach: discovery of dactylocyanines A\u2013H. Chem. Eur. J. 23, 14454\u201314461 (2017).","journal-title":"Chem. Eur. J."},{"key":"345_CR22","doi-asserted-by":"publisher","first-page":"11247","DOI":"10.1021\/acs.analchem.9b02216","volume":"91","author":"AE Fox Ramos","year":"2019","unstructured":"Fox Ramos, A. E. et al. CANPA: computer-assisted natural products anticipation. Anal. Chem. 91, 11247\u201311252 (2019).","journal-title":"Anal. Chem."},{"key":"345_CR23","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nchembio.1884","volume":"11","author":"MH Medema","year":"2015","unstructured":"Medema, M. H. & Fischbach, M. A. Computational approaches to natural product discovery. Nat. Chem. Biol. 11, 639\u2013648 (2015).","journal-title":"Nat. Chem. Biol."},{"key":"345_CR24","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1021\/ol100138k","volume":"12","author":"AL Lawrence","year":"2010","unstructured":"Lawrence, A. L. et al. A short biomimetic synthesis of the meroterpenoids guajadial and psidial A. Org. Lett. 12, 1676\u20131679 (2010).","journal-title":"Org. Lett."},{"key":"345_CR25","doi-asserted-by":"publisher","first-page":"5135","DOI":"10.1021\/ol702537q","volume":"9","author":"X-L Yang","year":"2007","unstructured":"Yang, X.-L., Hsieh, K.-L. & Liu, J.-K. Guajadial: an unusual meroterpenoid from guava leaves psidium guajava. Org. Lett. 9, 5135\u20135138 (2007).","journal-title":"Org. Lett."},{"key":"345_CR26","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1039\/a815187y","volume":"15","author":"IG Collado","year":"1998","unstructured":"Collado, I. G., Hanson, J. R. & Mac\u00edas-S\u00e1nchez, A. J. Recent advances in the chemistry of caryophyllene. Nat. Prod. Rep. 15, 187\u2013204 (1998).","journal-title":"Nat. Prod. Rep."},{"key":"345_CR27","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1021\/ol9024869","volume":"12","author":"H-Z Fu","year":"2010","unstructured":"Fu, H.-Z., Luo, Y.-M., Li, C.-J., Yang, J.-Z. & Zhang, D.-M. Psidials A\u2013C, three unusual meroterpenoids from the leaves of Psidium guajava L. Org. Lett. 12, 656\u2013659 (2010).","journal-title":"Org. Lett."},{"key":"345_CR28","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/s41598-017-01028-4","volume":"7","author":"G-H Tang","year":"2017","unstructured":"Tang, G.-H. et al. Psiguajadials A\u2013K: unusual Psidium meroterpenoids as phosphodiesterase-4 inhibitors from the leaves of Psidium guajava. Sci. Rep. 7, 1047 (2017).","journal-title":"Sci. Rep."},{"key":"345_CR29","doi-asserted-by":"publisher","first-page":"8700","DOI":"10.1021\/acs.orglett.9b03299","volume":"21","author":"S Ning","year":"2019","unstructured":"Ning, S., Liu, Z., Wang, Z., Liao, M. & Xie, Z. Biomimetic synthesis of psiguajdianone guided discovery of the meroterpenoids from Psidium guajava. Org. Lett. 21, 8700\u20138704 (2019).","journal-title":"Org. Lett."},{"key":"345_CR30","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1002\/cbdv.200800084","volume":"6","author":"Y-Q Chen","year":"2009","unstructured":"Chen, Y.-Q., Shen, Y.-H., Su, Y.-Q., Kong, L.-Y. & Zhang, W.-D. Incarviditone: a novel cytotoxic benzofuranone dimer from Incarvillea delavayi Bureau et Franchet. Chem. Biodivers. 6, 779\u2013783 (2009).","journal-title":"Chem. Biodivers."},{"key":"345_CR31","doi-asserted-by":"publisher","first-page":"4537","DOI":"10.1021\/ol302042u","volume":"14","author":"PD Brown","year":"2012","unstructured":"Brown, P. D., Willis, A. C., Sherburn, M. S. & Lawrence, A. L. Total synthesis of incarviditone and incarvilleatone. Org. Lett. 14, 4537\u20134539 (2012).","journal-title":"Org. Lett."},{"key":"345_CR32","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1021\/ol3004639","volume":"14","author":"Y-P Gao","year":"2012","unstructured":"Gao, Y.-P. et al. Incarvilleatone, a new cyclohexylethanoid dimer from Incarvillea younghusbandii and its inhibition against nitric oxide (NO) release. Org. Lett. 14, 1954\u20131957 (2012).","journal-title":"Org. Lett."},{"key":"345_CR33","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.trechm.2020.10.005","volume":"2","author":"AJE Novak","year":"2020","unstructured":"Novak, A. J. E. & Trauner, D. Reflections on racemic natural products. Trends Chem. 2, 1052\u20131065 (2020).","journal-title":"Trends Chem."},{"key":"345_CR34","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/0040-4020(76)87004-4","volume":"32","author":"K Kakinuma","year":"1976","unstructured":"Kakinuma, K., Hanson, C. A. & Rinehart, K. L. Spectinabilin, a new nitro-containing metabolite isolated from Streptomyces spectabilis. Tetrahedron 32, 217\u2013222 (1976).","journal-title":"Tetrahedron"},{"key":"345_CR35","doi-asserted-by":"publisher","first-page":"548","DOI":"10.7164\/antibiotics.54.548","volume":"54","author":"K Takahashi","year":"2001","unstructured":"Takahashi, K., Tsuda, E. & Kurosawa, K. SNF4435C and D, novel imimmosuppressants produced by a strain of Streptomyces spectabilis. II. Structure elucidation. J. Antibiot. 54, 548\u2013553 (2001).","journal-title":"J. Antibiot."},{"key":"345_CR36","doi-asserted-by":"publisher","first-page":"541","DOI":"10.7164\/antibiotics.54.541","volume":"54","author":"K Kurosawa","year":"2001","unstructured":"Kurosawa, K., Takahashi, K. & Tsuda, E. SNF4435C and D, novel immunosuppressants produced by a strain of Streptomyces spectabilis. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. 54, 541\u2013547 (2001).","journal-title":"J. Antibiot."},{"key":"345_CR37","doi-asserted-by":"publisher","first-page":"4475","DOI":"10.1021\/ol051790q","volume":"7","author":"CM Beaudry","year":"2005","unstructured":"Beaudry, C. M. & Trauner, D. Total synthesis of (\u2212)-SNF4435 C and (+)-SNF4435 D. Org. Lett. 7, 4475\u20134477 (2005).","journal-title":"Org. Lett."},{"key":"345_CR38","doi-asserted-by":"publisher","first-page":"7835","DOI":"10.1002\/anie.200602840","volume":"45","author":"M M\u00fcller","year":"2006","unstructured":"M\u00fcller, M. et al. Photochemical origin of the immunosuppressive SNF4435C\/D and formation of orinocin through \u201cpolyene splicing\u201d. Angew. Chem. Int. Ed. 45, 7835\u20137838 (2006).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR39","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/bs.alkal.2016.12.001","volume":"77","author":"T Lindel","year":"2017","unstructured":"Lindel, T. Chemistry and biology of the pyrrole\u2013imidazole alkaloids. Alkaloids Chem. Biol. 77, 117\u2013219 (2017).","journal-title":"Alkaloids Chem. Biol."},{"key":"345_CR40","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1002\/anie.200453937","volume":"43","author":"PS Baran","year":"2004","unstructured":"Baran, P. S., O\u2019Malley, D. P. & Zografos, A. L. Sceptrin as a potential biosynthetic precursor to complex pyrrole\u2013imidazole alkaloids: the total synthesis of ageliferin. Angew. Chem. Int. Ed. 43, 2674\u20132677 (2004).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR41","doi-asserted-by":"publisher","first-page":"4126","DOI":"10.1002\/anie.200600514","volume":"45","author":"BH Northrop","year":"2006","unstructured":"Northrop, B. H., O\u2019Malley, D. P., Zografos, A. L., Baran, P. S. & Houk, K. N. Mechanism of the vinylcyclobutane rearrangement of sceptrin to ageliferin and nagelamide E. Angew. Chem. Int. Ed. 45, 4126\u20134130 (2006).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR42","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1021\/np034077n","volume":"67","author":"T Endo","year":"2004","unstructured":"Endo, T. et al. Nagelamides A\u2013H, new dimeric bromopyrrole alkaloids from marine sponge Agelas species. J. Nat. Prod. 67, 1262\u20131267 (2004).","journal-title":"J. Nat. Prod."},{"key":"345_CR43","doi-asserted-by":"publisher","first-page":"16046","DOI":"10.1021\/ja067211+","volume":"128","author":"HC Brastianos","year":"2006","unstructured":"Brastianos, H. C. et al. Exiguamine A, an indoleamine-2,3-dioxygenase (IDO) inhibitor isolated from the marine sponge Neopetrosia exigua. J. Am. Chem. Soc. 128, 16046\u201316047 (2006).","journal-title":"J. Am. Chem. Soc."},{"key":"345_CR44","doi-asserted-by":"publisher","first-page":"4999","DOI":"10.1002\/chem.201103605","volume":"18","author":"V Sofiyev","year":"2012","unstructured":"Sofiyev, V., Lumb, J., Volgraf, M. & Trauner, D. Total synthesis of exiguamines A and B inspired by catecholamine chemistry. Chem. Eur. J. 18, 4999\u20135005 (2012).","journal-title":"Chem. Eur. J."},{"key":"345_CR45","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nchembio.107","volume":"4","author":"M Volgraf","year":"2008","unstructured":"Volgraf, M. et al. Biomimetic synthesis of the IDO inhibitors exiguamine A and B. Nat. Chem. Biol. 4, 535\u2013537 (2008).","journal-title":"Nat. Chem. Biol."},{"key":"345_CR46","doi-asserted-by":"publisher","first-page":"7009","DOI":"10.1039\/jr9650007009","volume":"1965","author":"H Minato","year":"1965","unstructured":"Minato, H. & Horibe, I. Structure and stereochemistry of Xanthumin, a stereoisomer of Xanthinin. J. Chem. Soc. Resumed 1965, 7009\u20137017 (1965).","journal-title":"J. Chem. Soc. Resumed"},{"key":"345_CR47","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1055\/s-2006-960817","volume":"65","author":"AA Ahmed","year":"1999","unstructured":"Ahmed, A. A., Mahmoud, A. A. & El-Gamal, A. A. A xanthanolide diol and a dimeric xanthanolide from Xanthium species. Planta Med. 65, 470\u2013472 (1999).","journal-title":"Planta Med."},{"key":"345_CR48","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1055\/s-0029-1185676","volume":"75","author":"AMM Nour","year":"2009","unstructured":"Nour, A. M. M. et al. The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from Xanthium brasilicum. Planta Med. 75, 1363\u20131368 (2009).","journal-title":"Planta Med."},{"key":"345_CR49","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1055\/s-0032-1328482","volume":"79","author":"L Wang","year":"2013","unstructured":"Wang, L. et al. Cytotoxic sesquiterpene lactones from aerial parts of Xanthium sibiricum. Planta Med. 79, 661\u2013665 (2013).","journal-title":"Planta Med."},{"key":"345_CR50","doi-asserted-by":"publisher","first-page":"16323","DOI":"10.1002\/anie.201710846","volume":"56","author":"J Feng","year":"2017","unstructured":"Feng, J. et al. Enantioselective and collective total syntheses of xanthanolides. Angew. Chem. Int. Ed. 56, 16323\u201316327 (2017).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR51","doi-asserted-by":"publisher","first-page":"6984","DOI":"10.1002\/anie.201202643","volume":"51","author":"W Ren","year":"2012","unstructured":"Ren, W. et al. Enantioselective and collective syntheses of xanthanolides involving a controllable dyotropic rearrangement of cis-\u03b2-lactones. Angew. Chem. Int. Ed. 51, 6984\u20136988 (2012).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR52","doi-asserted-by":"publisher","first-page":"14494","DOI":"10.1002\/anie.201406461","volume":"53","author":"H Shang","year":"2014","unstructured":"Shang, H. et al. Biomimetic synthesis: discovery of xanthanolide dimers. Angew. Chem. Int. Ed. 53, 14494\u201314498 (2014).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR53","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1021\/ol006681k","volume":"2","author":"SF Brady","year":"2000","unstructured":"Brady, S. F., Singh, M. P., Janso, J. E. & Clardy, J. Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus. Org. Lett. 2, 4047\u20134049 (2000).","journal-title":"Org. Lett."},{"key":"345_CR54","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1021\/np010390i","volume":"65","author":"R Jadulco","year":"2002","unstructured":"Jadulco, R. et al. New metabolites from sponge-derived fungi Curvularia lunata and Cladosporium herbarum. J. Nat. Prod. 65, 730\u2013733 (2002).","journal-title":"J. Nat. Prod."},{"key":"345_CR55","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/0031-9422(75)85055-2","volume":"14","author":"H Ejiri","year":"1975","unstructured":"Ejiri, H., Sankawa, U. & Shibata, S. Graciliformin and its acetates in Cladonia graciliformis. Phytochemistry 14, 277\u2013279 (1975).","journal-title":"Phytochemistry"},{"key":"345_CR56","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1021\/ol100298h","volume":"12","author":"H Yamazaki","year":"2010","unstructured":"Yamazaki, H., Koyama, N., \u014cmura, S. & Tomoda, H. New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2. Org. Lett. 12, 1572\u20131575 (2010).","journal-title":"Org. Lett."},{"key":"345_CR57","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1016\/S0040-4039(00)76385-4","volume":"9","author":"Y Ogihara","year":"1968","unstructured":"Ogihara, Y., Kobayashi, N. M. & Shibata, S. Further studies on the bianthraquinones of Penicillium islandicum Sopp. Tetrahedron Lett. 9, 1881\u20131886 (1968).","journal-title":"Tetrahedron Lett."},{"key":"345_CR58","doi-asserted-by":"publisher","first-page":"7917","DOI":"10.1002\/anie.200503678","volume":"44","author":"KC Nicolaou","year":"2005","unstructured":"Nicolaou, K. C., Lim, Y. H., Papageorgiou, C. D. & Piper, J. L. Total synthesis of (+)-rugulosin and (+)-2,2\u2032-epi-cytoskyrin A through cascade reactions. Angew. Chem. Int. Ed. 44, 7917\u20137921 (2005).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR59","doi-asserted-by":"publisher","first-page":"4001","DOI":"10.1021\/ja0685708","volume":"129","author":"KC Nicolaou","year":"2007","unstructured":"Nicolaou, K. C., Lim, Y. H., Piper, J. L. & Papageorgiou, C. D. Total syntheses of 2,2\u2032-epi-cytoskyrin A, rugulosin, and the alleged structure of rugulin. J. Am. Chem. Soc. 129, 4001\u20134013 (2007).","journal-title":"J. Am. Chem. Soc."},{"key":"345_CR60","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1248\/cpb.54.579","volume":"54","author":"A Agusta","year":"2006","unstructured":"Agusta, A., Ohashi, K. & Shibuya, H. Bisanthraquinone metabolites produced by the endophytic fungus Diaporthe sp. Chem. Pharm. Bull. 54, 579\u2013582 (2006).","journal-title":"Chem. Pharm. Bull."},{"key":"345_CR61","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.tetlet.2004.11.085","volume":"46","author":"E Manzo","year":"2005","unstructured":"Manzo, E. et al. New \u03b3-pyrone propionates from the Indian Ocean sacoglossan Placobranchus ocellatus. Tetrahedron Lett. 46, 465\u2013468 (2005).","journal-title":"Tetrahedron Lett."},{"key":"345_CR62","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1021\/ol0477428","volume":"7","author":"M Cueto","year":"2005","unstructured":"Cueto, M., D\u2019Croz, L., Mat\u00e9, J. L., San-Mart\u00edn, A. & Darias, J. Elysiapyrones from Elysia Diomedea. Do such metabolites evidence an enzymatically assisted electrocyclization cascade for the biosynthesis of their bicyclo[4.2.0]octane core? Org. Lett. 7, 415\u2013418 (2005).","journal-title":"Org. Lett."},{"key":"345_CR63","doi-asserted-by":"publisher","first-page":"4602","DOI":"10.1002\/anie.200500488","volume":"44","author":"AK Miller","year":"2005","unstructured":"Miller, A. K. & Trauner, D. Mining the tetraene manifold: total synthesis of complex pyrones from Placobranchus ocellatus. Angew. Chem. Int. Ed. 44, 4602\u20134606 (2005).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR64","doi-asserted-by":"publisher","first-page":"12105","DOI":"10.1002\/anie.202003643","volume":"59","author":"Q Wu","year":"2020","unstructured":"Wu, Q. et al. Complex polypropionates from a South China Sea photosynthetic mollusk: isolation and biomimetic synthesis highlighting novel rearrangements. Angew. Chem. Int. Ed. 59, 12105\u201312112 (2020).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR65","first-page":"65","volume":"32","author":"RG Eccles","year":"1888","unstructured":"Eccles, R. G. Calycanthine. Drug. Circular Chem. Gaz. 32, 65 (1888).","journal-title":"Drug. Circular Chem. Gaz."},{"key":"345_CR66","doi-asserted-by":"publisher","first-page":"5488","DOI":"10.1002\/anie.200700612","volume":"46","author":"A Steven","year":"2007","unstructured":"Steven, A. & Overman, L. E. Total synthesis of complex cyclotryptamine alkaloids: stereocontrolled construction of quaternary carbon stereocenters. Angew. Chem. Int. Ed. 46, 5488\u20135508 (2007).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR67","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1055\/s-2008-1032060","volume":"2008","author":"MA Schmidt","year":"2008","unstructured":"Schmidt, M. A. & Movassaghi, M. New strategies for the synthesis of hexahydropyrroloindole alkaloids inspired by biosynthetic hypotheses. Synlett 2008, 313\u2013324 (2008).","journal-title":"Synlett"},{"key":"345_CR68","first-page":"16318","volume":"21","author":"BM Trost","year":"2015","unstructured":"Trost, B. M. & Osipov, M. Recent advances on the total syntheses of the communesin alkaloids and perophoramidine. Chem. Weinh. Bergstr. Ger. 21, 16318\u201316343 (2015).","journal-title":"Chem. Weinh. Bergstr. Ger."},{"key":"345_CR69","doi-asserted-by":"publisher","first-page":"6715","DOI":"10.3390\/molecules20046715","volume":"20","author":"J-B Xu","year":"2015","unstructured":"Xu, J.-B. & Cheng, K.-J. Studies on the alkaloids of the calycanthaceae and their syntheses. Molecules 20, 6715\u20136738 (2015).","journal-title":"Molecules"},{"key":"345_CR70","doi-asserted-by":"publisher","first-page":"5262","DOI":"10.1016\/j.tet.2006.01.105","volume":"62","author":"JA May","year":"2006","unstructured":"May, J. A. & Stoltz, B. The structural and synthetic implications of the biosynthesis of the calycanthaceous alkaloids, the communesins, and nomofungin. Tetrahedron 62, 5262\u20135271 (2006).","journal-title":"Tetrahedron"},{"key":"345_CR71","doi-asserted-by":"publisher","first-page":"11685","DOI":"10.1021\/jacs.0c04760","volume":"142","author":"JJ Dotson","year":"2020","unstructured":"Dotson, J. J., Bachman, J. L., Garcia-Garibay, M. A. & Garg, N. K. Discovery and total synthesis of a bis(cyclotryptamine) alkaloid bearing the elusive piperidinoindoline scaffold. J. Am. Chem. Soc. 142, 11685\u201311690 (2020).","journal-title":"J. Am. Chem. Soc."},{"key":"345_CR72","doi-asserted-by":"publisher","first-page":"4131","DOI":"10.1016\/S0040-4020(01)97925-6","volume":"23","author":"ES Hall","year":"1967","unstructured":"Hall, E. S., McCapra, F. & Scott, A. I. Biogenetic-type synthesis of the calycanthaceous alkaloids. Tetrahedron 23, 4131\u20134141 (1967).","journal-title":"Tetrahedron"},{"key":"345_CR73","doi-asserted-by":"publisher","first-page":"4259","DOI":"10.1016\/0040-4039(96)00811-8","volume":"37","author":"M Gavagnin","year":"1996","unstructured":"Gavagnin, M., Mollo, E., Cimino, G. & Ortea, J. A new \u03b3-dihydropyrone-propionate from the Caribbean sacoglossan Tridachia crispata. Tetrahedron Lett. 37, 4259\u20134262 (1996).","journal-title":"Tetrahedron Lett."},{"key":"345_CR74","doi-asserted-by":"publisher","first-page":"5966","DOI":"10.1021\/ja900369z","volume":"131","author":"P Sharma","year":"2009","unstructured":"Sharma, P., Lygo, B., Lewis, W. & Moses, J. E. Biomimetic synthesis and structural reassignment of the tridachiahydropyrones. J. Am. Chem. Soc. 131, 5966\u20135972 (2009).","journal-title":"J. Am. Chem. Soc."},{"key":"345_CR75","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.bjp.2015.07.028","volume":"25","author":"M Gavagnin","year":"2015","unstructured":"Gavagnin, M., Mollo, E. & Cimino, G. Is phototridachiahydropyrone a true natural product? Rev. Bras. Farmacogn. 25, 588\u2013591 (2015).","journal-title":"Rev. Bras. Farmacogn."},{"key":"345_CR76","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.1002\/anie.200353160","volume":"43","author":"B Bister","year":"2004","unstructured":"Bister, B. et al. Abyssomicin C \u2014 A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid\/tetrahydrofolate biosynthesis pathway. Angew. Chem. Int. Ed. 43, 2574\u20132576 (2004).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR77","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1021\/ja067083p","volume":"129","author":"KC Nicolaou","year":"2007","unstructured":"Nicolaou, K. C. & Harrison, S. T. Total synthesis of abyssomicin C, atrop-abyssomicin C, and abyssomicin D: implications for natural origins of atrop-abyssomicin C. J. Am. Chem. Soc. 129, 429\u2013440 (2007).","journal-title":"J. Am. Chem. Soc."},{"key":"345_CR78","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.1002\/anie.200601116","volume":"45","author":"KC Nicolaou","year":"2006","unstructured":"Nicolaou, K. C. & Harrison, S. T. Total synthesis of abyssomicin C and atrop-abyssomicin C. Angew. Chem. Int. Ed. 45, 3256\u20133260 (2006).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR79","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/ja.2007.54","volume":"60","author":"S Keller","year":"2007","unstructured":"Keller, S. et al. Abyssomicins G and H and atrop-abyssomicin C from the marine Verrucosispora strain AB-18-032. J. Antibiot. 60, 391\u2013394 (2007).","journal-title":"J. Antibiot."},{"key":"345_CR80","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/nchem.2336","volume":"7","author":"P Ellerbrock","year":"2015","unstructured":"Ellerbrock, P., Armanino, N., Ilg, M. K., Webster, R. & Trauner, D. An eight-step synthesis of epicolactone reveals its biosynthetic origin. Nat. Chem. 7, 879\u2013882 (2015).","journal-title":"Nat. Chem."},{"key":"345_CR81","doi-asserted-by":"publisher","first-page":"28560","DOI":"10.1039\/D0RA05532H","volume":"10","author":"Z Yan","year":"2020","unstructured":"Yan, Z. et al. Fused multicyclic polyketides with a two-spiro-carbon skeleton from mangrove-derived endophytic fungus Epicoccum nigrum SCNU-F0002. RSC Adv. 10, 28560\u201328566 (2020).","journal-title":"RSC Adv."},{"key":"345_CR82","doi-asserted-by":"publisher","first-page":"4255","DOI":"10.1021\/ol701845t","volume":"9","author":"TJ Greshock","year":"2007","unstructured":"Greshock, T. J. & Williams, R. M. Improved biomimetic total synthesis of d,l-stephacidin A. Org. Lett. 9, 4255\u20134258 (2007).","journal-title":"Org. Lett."},{"key":"345_CR83","doi-asserted-by":"publisher","first-page":"16143","DOI":"10.1039\/C5CC05877E","volume":"51","author":"W-F Qin","year":"2015","unstructured":"Qin, W.-F. et al. Total synthesis of (\u2212)-depyranoversicolamide B. Chem. Commun. 51, 16143\u201316146 (2015).","journal-title":"Chem. Commun."},{"key":"345_CR84","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3390\/md15020043","volume":"15","author":"X Xu","year":"2017","unstructured":"Xu, X., Zhang, X., Nong, X., Wang, J. & Qi, S. Brevianamides and mycophenolic acid derivatives from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Mar. Drugs 15, 43 (2017).","journal-title":"Mar. Drugs"},{"key":"345_CR85","first-page":"368a","volume":"1968","author":"L Crombie","year":"1968","unstructured":"Crombie, L. & Ponsford, R. Synthesis of (\u00b1)-deoxybruceol. Chem. Commun. Lond. 1968, 368a (1968).","journal-title":"Chem. Commun. Lond."},{"key":"345_CR86","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1039\/J39710000788","volume":"1971","author":"L Crombie","year":"1971","unstructured":"Crombie, L. & Ponsford, R. Pyridine-catalysed condensation of citral with phloroglucinols, a novel reaction leading to tetracyclic bis-ethers and chromenes. Two-step synthesis of (\u00b1)-deoxybruceol. J. Chem. Soc. C Org. 1971, 788\u2013795 (1971).","journal-title":"J. Chem. Soc. C Org."},{"key":"345_CR87","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1039\/p29810000583","volume":"2","author":"EL Ghisalberti","year":"1981","unstructured":"Ghisalberti, E. L. et al. Structural studies in the bruceol system. J. Chem. Soc. Perkin Trans. 2, 583\u2013589 (1981).","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"345_CR88","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1021\/acs.joc.9b02862","volume":"85","author":"AJ Day","year":"2020","unstructured":"Day, A. J., Sumby, C. J. & George, J. H. Biomimetic synthetic studies on the bruceol family of meroterpenoid natural products. J. Org. Chem. 85, 2103\u20132117 (2020).","journal-title":"J. Org. Chem."},{"key":"345_CR89","doi-asserted-by":"publisher","first-page":"6606","DOI":"10.1021\/jo00101a019","volume":"59","author":"N Harada","year":"1994","unstructured":"Harada, N. et al. Total synthesis, absolute configuration, and later isolation of (\u2212)-prehalenaquinone, a putative biosynthetic precursor to the marine natural products: halenaquinone and xestoquinone. J. Org. Chem. 59, 6606\u20136613 (1994).","journal-title":"J. Org. Chem."},{"key":"345_CR90","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1021\/acscentsci.6b00293","volume":"3","author":"BS Matsuura","year":"2017","unstructured":"Matsuura, B. S., K\u00f6lle, P., Trauner, D., de Vivie-Riedle, R. & Meier, R. Unravelling photochemical relationships among natural products from Aplysia dactylomela. ACS Cent. Sci. 3, 39\u201346 (2017).","journal-title":"ACS Cent. Sci."},{"key":"345_CR91","doi-asserted-by":"publisher","first-page":"3564","DOI":"10.1021\/acs.orglett.7b01525","volume":"19","author":"TK Kotammagari","year":"2017","unstructured":"Kotammagari, T. K., Gonnade, R. G. & Bhattacharya, A. K. Biomimetic total synthesis of angiopterlactone B and other potential natural products. Org. Lett. 19, 3564\u20133567 (2017).","journal-title":"Org. Lett."},{"key":"345_CR92","doi-asserted-by":"publisher","first-page":"7678","DOI":"10.1002\/chem.201001474","volume":"16","author":"KC Nicolaou","year":"2010","unstructured":"Nicolaou, K. C., Sanchini, S., Wu, T. R. & Sarlah, D. Total synthesis and structural revision of biyouyanagin B. Chem. Eur. J. 16, 7678\u20137682 (2010).","journal-title":"Chem. Eur. J."},{"key":"345_CR93","doi-asserted-by":"publisher","first-page":"6199","DOI":"10.1002\/anie.201001862","volume":"49","author":"F L\u00f6bermann","year":"2010","unstructured":"L\u00f6bermann, F., Mayer, P. & Trauner, D. Biomimetic synthesis of (\u2212)-pycnanthuquinone C through the Diels\u2013Alder reaction of a vinyl quinone. Angew. Chem. Int. Ed. 49, 6199\u20136202 (2010).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR94","doi-asserted-by":"publisher","first-page":"7886","DOI":"10.1002\/anie.201702775","volume":"56","author":"D Ma","year":"2017","unstructured":"Ma, D., Liu, Y. & Wang, Z. Biomimetic total synthesis of (\u00b1)-homodimericin A. Angew. Chem. Int. Ed. 56, 7886\u20137889 (2017).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR95","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6597","volume":"5","author":"D Stichnoth","year":"2014","unstructured":"Stichnoth, D. et al. Photochemical formation of intricarene. Nat. Commun. 5, 5597 (2014).","journal-title":"Nat. Commun."},{"key":"345_CR96","doi-asserted-by":"publisher","first-page":"8421","DOI":"10.1002\/anie.201602869","volume":"128","author":"PD Brown","year":"2016","unstructured":"Brown, P. D. & Lawrence, A. L. Total synthesis of millingtonine. Angew. Chem. Int. Ed. 128, 8421\u20138425 (2016).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR97","doi-asserted-by":"publisher","first-page":"13515","DOI":"10.1002\/ange.201307875","volume":"125","author":"PD Brown","year":"2013","unstructured":"Brown, P. D., Willis, A. C., Sherburn, M. S. & Lawrence, A. L. Total synthesis and structural revision of the alkaloid incargranine B. Angew. Chem. 125, 13515\u201313517 (2013).","journal-title":"Angew. Chem."},{"key":"345_CR98","doi-asserted-by":"publisher","first-page":"15135","DOI":"10.1021\/jacs.9b06355","volume":"141","author":"TJ Purgett","year":"2019","unstructured":"Purgett, T. J., Dyer, M. W., Bickel, B., McNeely, J. & Porco, J. A. Gold(I)-mediated cycloisomerization\/cycloaddition enables bioinspired syntheses of neonectrolides B\u2013E and analogues. J. Am. Chem. Soc. 141, 15135\u201315144 (2019).","journal-title":"J. Am. Chem. Soc."},{"key":"345_CR99","doi-asserted-by":"publisher","first-page":"15515","DOI":"10.1021\/jacs.9b08892","volume":"141","author":"AJE Novak","year":"2019","unstructured":"Novak, A. J. E., Grigglestone, C. E. & Trauner, D. A biomimetic synthesis elucidates the origin of preuisolactone A. J. Am. Chem. Soc. 141, 15515\u201315518 (2019).","journal-title":"J. Am. Chem. Soc."},{"key":"345_CR100","doi-asserted-by":"publisher","first-page":"3509","DOI":"10.1002\/anie.201600106","volume":"55","author":"H Li","year":"2016","unstructured":"Li, H., Korotkov, A., Chapman, C. W., Eastman, A. & Wu, J. Enantioselective formal syntheses of 11 nuphar alkaloids and discovery of potent apoptotic monomeric analogues. Angew. Chem. Int. Ed. 55, 3509\u20133513 (2016).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR101","doi-asserted-by":"publisher","first-page":"5521","DOI":"10.1002\/anie.201912613","volume":"59","author":"M Breunig","year":"2020","unstructured":"Breunig, M., Yuan, P. & Gaich, T. An unexpected transannular [4+2] cycloaddition during the total synthesis of (+)-norcembrene 5. Angew. Chem. Int. Ed. 59, 5521\u20135525 (2020).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR102","doi-asserted-by":"publisher","first-page":"20201","DOI":"10.1021\/jacs.0c10660","volume":"142","author":"KC Nicolaou","year":"2020","unstructured":"Nicolaou, K. C., Chen, Q., Li, R., Anami, Y. & Tsuchikama, K. Total synthesis of the monomeric unit of lomaiviticin A. J. Am. Chem. Soc. 142, 20201\u201320207 (2020).","journal-title":"J. Am. Chem. Soc."},{"key":"345_CR103","doi-asserted-by":"publisher","first-page":"13818","DOI":"10.1021\/acs.joc.0c01930","volume":"85","author":"K Zheng","year":"2020","unstructured":"Zheng, K., Shen, D., Zhang, B. & Hong, R. Landscape of lankacidin biomimetic synthesis: structural revisions and biogenetic implications. J. Org. Chem. 85, 13818\u201313836 (2020).","journal-title":"J. Org. Chem."},{"key":"345_CR104","doi-asserted-by":"publisher","first-page":"16490","DOI":"10.1021\/ja8074852","volume":"130","author":"S Su","year":"2008","unstructured":"Su, S., Seiple, I. B., Young, I. S. & Baran, P. S. Total syntheses of (\u00b1)-massadine and massadine chloride. J. Am. Chem. Soc. 130, 16490\u201316491 (2008).","journal-title":"J. Am. Chem. Soc."},{"key":"345_CR105","doi-asserted-by":"publisher","first-page":"5079","DOI":"10.1002\/anie.201411350","volume":"54","author":"S Strych","year":"2015","unstructured":"Strych, S. et al. Biomimetic total synthesis of santalin Y. Angew. Chem. Int. Ed. 54, 5079\u20135083 (2015).","journal-title":"Angew. Chem. Int. Ed."},{"key":"345_CR106","doi-asserted-by":"publisher","first-page":"5936","DOI":"10.1021\/ol302849v","volume":"14","author":"Y Gao","year":"2012","unstructured":"Gao, Y. et al. Isolation and biomimetic synthesis of (\u00b1)-guajadial B, a novel meroterpenoid from Psidium guajava. Org. Lett. 14, 5936\u20135939 (2012).","journal-title":"Org. Lett."},{"key":"345_CR107","doi-asserted-by":"publisher","first-page":"6370","DOI":"10.1021\/jacs.1c02674","volume":"143","author":"B Yang","year":"2021","unstructured":"Yang, B. et al. Asymmetric total synthesis and biosynthetic implications of perovskones, hydrangenone, and hydrangenone B. J. Am. Chem. Soc. 143, 6370\u20136375 (2021).","journal-title":"J. Am. Chem. Soc."},{"key":"345_CR108","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.chempr.2020.11.010","volume":"7","author":"X Long","year":"2021","unstructured":"Long, X., Wu, H., Ding, Y., Qu, C. & Deng, J. Biosynthetically inspired divergent syntheses of merocytochalasans. Chem 7, 212\u2013223 (2021).","journal-title":"Chem"}],"updated-by":[{"DOI":"10.1038\/s41570-022-00374-w","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000}}],"container-title":["Nature Reviews Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41570-021-00345-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41570-021-00345-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41570-021-00345-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T15:15:29Z","timestamp":1669302929000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41570-021-00345-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,14]]},"references-count":108,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["345"],"URL":"https:\/\/doi.org\/10.1038\/s41570-021-00345-7","relation":{"correction":[{"id-type":"doi","id":"10.1038\/s41570-022-00374-w","asserted-by":"object"}]},"ISSN":["2397-3358"],"issn-type":[{"value":"2397-3358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,14]]},"assertion":[{"value":"13 November 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2022","order":3,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":4,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":5,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41570-022-00374-w","URL":"https:\/\/doi.org\/10.1038\/s41570-022-00374-w","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}