{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:15:19Z","timestamp":1790680519084,"version":"4.1.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Endocrinol"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1038\/s41574-021-00475-4","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T12:08:23Z","timestamp":1612181303000},"page":"193-194","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clustering for a better prediction of type 2 diabetes mellitus"],"prefix":"10.1038","volume":"17","author":[{"given":"Am\u00e9lie","family":"Bonnefond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-0784","authenticated-orcid":false,"given":"Philippe","family":"Froguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"issue":"Suppl. 1","key":"475_CR1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2337\/dc21-S002","volume":"44","author":"American Diabetes Association","year":"2021","unstructured":"American Diabetes Association. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021. Diabetes Care 44 (Suppl. 1), 15\u201333 (2021).","journal-title":"Diabetes Care"},{"key":"475_CR2","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/j.jdiacomp.2017.08.005","volume":"31","author":"E Gourgari","year":"2017","unstructured":"Gourgari, E., Wilhelm, E. E., Hassanzadeh, H., Aroda, V. R. & Shoulson, I. A comprehensive review of the FDA-approved labels of diabetes drugs: Indications, safety, and emerging cardiovascular safety data. J. Diabetes Complications 31, 1719\u20131727 (2017).","journal-title":"J. Diabetes Complications"},{"key":"475_CR3","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/S0140-6736(09)60619-X","volume":"373","author":"AG Tab\u00e1k","year":"2009","unstructured":"Tab\u00e1k, A. G. et al. Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet 373, 2215\u20132221 (2009).","journal-title":"Lancet"},{"key":"475_CR4","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S2213-8587(18)30051-2","volume":"6","author":"E Ahlqvist","year":"2018","unstructured":"Ahlqvist, E. et al. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol. 6, 361\u2013369 (2018).","journal-title":"Lancet Diabetes Endocrinol."},{"key":"475_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002654","volume":"15","author":"MS Udler","year":"2018","unstructured":"Udler, M. S. et al. Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis. PLoS Med. 15, e1002654 (2018).","journal-title":"PLoS Med."},{"key":"475_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1116-9","author":"R Wagner","year":"2021","unstructured":"Wagner, R. et al. Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes. Nat. Med. https:\/\/doi.org\/10.1038\/s41591-020-1116-9 (2021).","journal-title":"Nat. Med."},{"key":"475_CR7","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.cmet.2014.12.020","volume":"21","author":"A Bonnefond","year":"2015","unstructured":"Bonnefond, A. & Froguel, P. Rare and common genetic events in type 2 diabetes: what should biologists know? Cell Metab. 21, 357\u2013368 (2015).","journal-title":"Cell Metab."},{"key":"475_CR8","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.cger.2008.03.005","volume":"24","author":"JE Morley","year":"2008","unstructured":"Morley, J. E. Diabetes and aging: epidemiologic overview. Clin. Geriatr. Med. 24, 395\u2013405 (2008).","journal-title":"Clin. Geriatr. Med."}],"container-title":["Nature Reviews Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41574-021-00475-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41574-021-00475-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41574-021-00475-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:49:28Z","timestamp":1684619368000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41574-021-00475-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["475"],"URL":"https:\/\/doi.org\/10.1038\/s41574-021-00475-4","relation":{},"ISSN":["1759-5029","1759-5037"],"issn-type":[{"value":"1759-5029","type":"print"},{"value":"1759-5037","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,1]]},"assertion":[{"value":"1 February 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}