{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:26:02Z","timestamp":1787660762713,"version":"build-2736575974"},"reference-count":230,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Gastroenterol Hepatol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1038\/s41575-026-01196-7","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:57:37Z","timestamp":1776862657000},"page":"688-702","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u03b3\u03b4 T cells in colorectal and liver cancer"],"prefix":"10.1038","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4160-7103","authenticated-orcid":false,"given":"Dieter","family":"Kabelitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Zeissig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"1196_CR1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev-immunol-032713-120216","volume":"32","author":"YH Chien","year":"2014","unstructured":"Chien, Y. H., Meyer, C. & Bonneville, M. \u03b3\u03b4 T cells: first line of defense and beyond. Annu. Rev. Immunol. 32, 121\u2013155 (2014).","journal-title":"Annu. Rev. Immunol."},{"key":"1196_CR2","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/s41577-020-0345-y","volume":"20","author":"DG Pellicci","year":"2020","unstructured":"Pellicci, D. G., Koay, H. F. & Berzins, S. P. Thymic development of unconventional T cells: how NKT cells, MAIT cells and \u03b3\u03b4 T cells emerge. Nat. Rev. Immunol. 20, 756\u2013770 (2020).","journal-title":"Nat. Rev. Immunol."},{"key":"1196_CR3","doi-asserted-by":"publisher","first-page":"1343718","DOI":"10.3389\/fimmu.2023.1343718","volume":"14","author":"SW Lee","year":"2024","unstructured":"Lee, S. W., Park, H. J., Van Kaer, L. & Hong, S. Role of CD1d and iNKT cells in regulating intestinal inflammation. Front. Immunol. 14, 1343718 (2024).","journal-title":"Front. Immunol."},{"key":"1196_CR4","doi-asserted-by":"publisher","first-page":"eadu4172","DOI":"10.1126\/sciadv.adu4172","volume":"11","author":"Z Wu","year":"2025","unstructured":"Wu, Z., Chen, X., Han, F. & Leeansyah, E. MAIT cell homing in intestinal homeostasis and inflammation. Sci. Adv. 11, eadu4172 (2025).","journal-title":"Sci. Adv."},{"key":"1196_CR5","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s41568-025-00830-x","volume":"25","author":"DX Beringer","year":"2025","unstructured":"Beringer, D. X. et al. Disrupting the balance between activating and inhibitory receptors of \u03b3\u03b4T cells for effective cancer immunotherapy. Nat. Rev. Cancer 25, 590\u2013612 (2025).","journal-title":"Nat. Rev. Cancer"},{"key":"1196_CR6","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/s41577-020-00452-4","volume":"21","author":"JC Ribot","year":"2021","unstructured":"Ribot, J. C., Lopes, N. & Silva-Santos, B. \u03b3\u03b4 T cells in tissue physiology and surveillance. Nat. Rev. Immunol. 21, 221\u2013232 (2021).","journal-title":"Nat. Rev. Immunol."},{"key":"1196_CR7","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1126\/science.1069639","volume":"296","author":"J Jameson","year":"2002","unstructured":"Jameson, J. et al. A role for skin gammadelta T cells in wound repair. Science 296, 747\u2013749 (2002).","journal-title":"Science"},{"key":"1196_CR8","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nri.2017.101","volume":"17","author":"MM Nielsen","year":"2017","unstructured":"Nielsen, M. M., Witherden, D. A. & Havran, W. L. \u03b3\u03b4 T cells in homeostasis and host defence of epithelial barrier tissues. Nat. Rev. Immunol. 17, 733\u2013745 (2017).","journal-title":"Nat. Rev. Immunol."},{"key":"1196_CR9","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nri2781","volume":"10","author":"M Bonneville","year":"2010","unstructured":"Bonneville, M., O\u2019Brien, R. L. & Born, W. K.\u00a0\u03b3\u03b4\u00a0T cell effector functions: a blend of innate programming and acquired plasticity. Nat. Rev. Immunol. 10, 467\u2013478 (2010).","journal-title":"Nat. Rev. Immunol."},{"key":"1196_CR10","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41392-023-01653-8","volume":"8","author":"Y Hu","year":"2023","unstructured":"Hu, Y. et al. \u03b3\u03b4 T cells: origin and fate, subsets, diseases and immunotherapy. Signal Transduct. Target. Ther. 8, 434 (2023).","journal-title":"Signal Transduct. Target. Ther."},{"key":"1196_CR11","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1084\/jem.171.5.1597","volume":"171","author":"CM Parker","year":"1990","unstructured":"Parker, C. M. et al. Evidence for extrathymic changes in the T cell receptor gamma\/delta repertoire. J. Exp. Med. 171, 1597\u20131612 (1990).","journal-title":"J. Exp. Med."},{"key":"1196_CR12","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1093\/intimm\/10.8.1067","volume":"10","author":"D Wesch","year":"1998","unstructured":"Wesch, D., Hinz, T. & Kabelitz, D. Analysis of the TCR Vgamma repertoire in healthy donors and HIV-1-infected individuals. Int. Immunol. 10, 1067\u20131075 (1998).","journal-title":"Int. Immunol."},{"key":"1196_CR13","doi-asserted-by":"publisher","first-page":"eabo4365","DOI":"10.1126\/sciimmunol.abo4365","volume":"8","author":"L Perriman","year":"2023","unstructured":"Perriman, L. et al. A three-stage developmental pathway for human V\u03b39V\u03b42 T cells within the postnatal thymus. Sci. Immunol. 8, eabo4365 (2023).","journal-title":"Sci. Immunol."},{"key":"1196_CR14","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1002\/eji.1830210429","volume":"121","author":"K Deusch","year":"1991","unstructured":"Deusch, K. et al. A major fraction of human intraepithelial lymphocytes simultaneously expresses the \u03b3\/\u03b4 T cell receptor, the CD8 accessory molecule and preferentially uses the V\u03b41 gene segment. Eur. J. Immunol. 121, 1053\u20131059 (1991).","journal-title":"Eur. J. Immunol."},{"key":"1196_CR15","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.clim.2004.05.003","volume":"113","author":"T Kenna","year":"2004","unstructured":"Kenna, T. et al. Distinct subpopulations of\u00a0\u03b3\u03b4\u00a0T cells are present in normal and tumor-bearing human liver. Clin. Immunol. 113, 56\u201363 (2004).","journal-title":"Clin. Immunol."},{"key":"1196_CR16","doi-asserted-by":"publisher","first-page":"eadn3954","DOI":"10.1126\/sciimmunol.adn3954","volume":"9","author":"JI Gray","year":"2024","unstructured":"Gray, J. I. et al. Human \u03b3\u03b4 T cells in diverse tissues exhibit site-specific maturation dynamics across the life span. Sci. Immunol. 9, eadn3954 (2024).","journal-title":"Sci. Immunol."},{"key":"1196_CR17","doi-asserted-by":"publisher","first-page":"2870","DOI":"10.1182\/bloodadvances.2019032409","volume":"3","author":"GJJ Kierkels","year":"2019","unstructured":"Kierkels, G. J. J. et al. Identification of a tumor-specific allo-HLA-restricted \u03b3\u03b4TCR. Blood Adv. 3, 2870\u20132882 (2019).","journal-title":"Blood Adv."},{"key":"1196_CR18","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1182\/blood-2012-05-430470","volume":"120","author":"C Harly","year":"2012","unstructured":"Harly, C. et al. Key implication of CD277\/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human \u03b3\u03b4 T-cell subset. Blood 120, 2269\u20132279 (2012).","journal-title":"Blood"},{"key":"1196_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202451068","volume":"54","author":"T Herrmann","year":"2024","unstructured":"Herrmann, T. & Karunakaran, M. M. Phosphoantigen recognition by V\u03b39V\u03b42 T cells. Eur. J. Immunol. 54, e2451068 (2024).","journal-title":"Eur. J. Immunol."},{"key":"1196_CR20","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.3389\/fimmu.2017.01714","volume":"8","author":"G Gruenbacher","year":"2017","unstructured":"Gruenbacher, G. & Thurnher, M. Mevalonate metabolism in immuno-oncology. Front. Immunol. 8, 1714 (2017).","journal-title":"Front. Immunol."},{"key":"1196_CR21","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1365-2141.2008.07435.x","volume":"144","author":"AJ Roelofs","year":"2009","unstructured":"Roelofs, A. J. et al. Peripheral blood monocytes are responsible for\u00a0\u03b3\u03b4\u00a0T cell activation induced by zoledronic acid through accumulation of IPP\/DMAPP. Br. J. Haematol. 144, 245\u2013250 (2009).","journal-title":"Br. J. Haematol."},{"key":"1196_CR22","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S0014-5793(01)03191-X","volume":"509","author":"M Hintz","year":"2001","unstructured":"Hintz, M. et al. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Lett. 509, 317\u2013322 (2001).","journal-title":"FEBS Lett."},{"key":"1196_CR23","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.immuni.2014.03.003","volume":"40","author":"A Sandstrom","year":"2014","unstructured":"Sandstrom, A. et al. The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human V\u03b39V\u03b42 T cells. Immunity 40, 490\u2013500 (2014).","journal-title":"Immunity"},{"key":"1196_CR24","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/s41586-023-06525-3","volume":"621","author":"L Yuan","year":"2023","unstructured":"Yuan, L. et al. Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate V\u03b39V\u03b42 T cells. Nature 621, 840\u2013848 (2023).","journal-title":"Nature"},{"key":"1196_CR25","doi-asserted-by":"publisher","first-page":"E7311","DOI":"10.1073\/pnas.1707547114","volume":"114","author":"S Gu","year":"2017","unstructured":"Gu, S. et al. Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on V\u03b39V\u03b42 T cell activation. Proc. Natl Acad. Sci. USA 114, E7311\u2013E7320 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1196_CR26","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1038\/s41590-024-01892-z","volume":"25","author":"TS Fulford","year":"2024","unstructured":"Fulford, T. S. et al. V\u03b39V\u03b42 T cells recognize butyrophilin 2A1 and 3A1 heteromers. Nat. Immunol. 25, 1355\u20131366 (2024).","journal-title":"Nat. Immunol."},{"key":"1196_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41938-8","volume":"14","author":"MM Karunakaran","year":"2023","unstructured":"Karunakaran, M. M. et al. A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human \u03b3\u03b4 T cell phosphoantigen sensing. Nat. Commun. 14, 7617 (2023).","journal-title":"Nat. Commun."},{"key":"1196_CR28","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.4049\/jimmunol.175.4.2144","volume":"175","author":"B Rincon-Orozco","year":"2005","unstructured":"Rincon-Orozco, B. et al. Activation of V\u03b39V\u03b42 T cells by NKG2D. J. Immunol. 175, 2144\u20132151 (2005).","journal-title":"J. Immunol."},{"key":"1196_CR29","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1002\/eji.200838409","volume":"39","author":"O Toutirais","year":"2009","unstructured":"Toutirais, O. et al. DNAX accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by V\u03b39V\u03b42 T cells. Eur. J. Immunol. 39, 1361\u20131368 (2009).","journal-title":"Eur. J. Immunol."},{"key":"1196_CR30","doi-asserted-by":"publisher","first-page":"851","DOI":"10.3389\/fimmu.2018.00851","volume":"9","author":"B Silva-Santos","year":"2018","unstructured":"Silva-Santos, B. & Strid, J. Working in \u201cNK mode\u201d: natural killer group 2 member D and natural cytotoxicity receptors in stress-surveillance by \u03b3\u03b4 T cells. Front. Immunol. 9, 851 (2018).","journal-title":"Front. Immunol."},{"key":"1196_CR31","doi-asserted-by":"publisher","first-page":"109871","DOI":"10.1016\/j.celrep.2021.109871","volume":"37","author":"V Cazzetta","year":"2021","unstructured":"Cazzetta, V. et al. NKG2A expression identifies a subset of human V\u03b42 T cells exerting the highest antitumor effector functions. Cell Rep. 37, 109871 (2021).","journal-title":"Cell Rep."},{"key":"1196_CR32","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1002\/eji.201243150","volume":"43","author":"P Dokouhaki","year":"2013","unstructured":"Dokouhaki, P. et al. NKG2D regulates production of soluble TRAIL by ex vivo expanded human \u03b3\u03b4 T cells. Eur. J. Immunol. 43, 3175\u20133182 (2013).","journal-title":"Eur. J. Immunol."},{"key":"1196_CR33","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1093\/intimm\/dxy007","volume":"30","author":"M Lettau","year":"2018","unstructured":"Lettau, M. et al. Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells. Int. Immunol. 30, 215\u2013228 (2018).","journal-title":"Int. Immunol."},{"key":"1196_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41634-7","volume":"14","author":"PA Sandoz","year":"2023","unstructured":"Sandoz, P. A. et al. Modulation of lytic molecules restrain serial killing in \u03b3\u03b4 T lymphocytes. Nat. Commun. 14, 6035 (2023).","journal-title":"Nat. Commun."},{"key":"1196_CR35","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1182\/blood-2004-01-0331","volume":"104","author":"DF Angelini","year":"2004","unstructured":"Angelini, D. F. et al. Fc\u03b3RIII discriminates between 2 subsets of V\u03b39V\u03b42 effector cells with different responses and activation pathways. Blood 104, 1801\u20131807 (2004).","journal-title":"Blood"},{"key":"1196_CR36","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/1471-2172-10-50","volume":"10","author":"EM Urban","year":"2009","unstructured":"Urban, E. M. et al. Control of CD56 expression and tumor cell cytotoxicity in human V\u03b32V\u03b42 T cells. BMC Immunol. 10, 50 (2009).","journal-title":"BMC Immunol."},{"key":"1196_CR37","doi-asserted-by":"publisher","first-page":"4232","DOI":"10.1158\/1078-0432.CCR-07-4912","volume":"14","author":"AA Alexander","year":"2008","unstructured":"Alexander, A. A. et al. Isopentenyl pyrophosphate-activated CD56 + \u03b3\u03b4 T lymphocytes display potent antitumor activity toward human squamous cell carcinoma. Clin. Cancer Res. 14, 4232\u20134240 (2008).","journal-title":"Clin. Cancer Res."},{"key":"1196_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42619-2","volume":"14","author":"D Lee","year":"2023","unstructured":"Lee, D. et al. Unlocking the potential of allogeneic V\u03b42 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR\/IL-15 engineering. Nat. Commun. 14, 6942 (2023).","journal-title":"Nat. Commun."},{"key":"1196_CR39","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1006\/cimm.2001.1850","volume":"212","author":"D Wesch","year":"2001","unstructured":"Wesch, D., Glatzel, A. & Kabelitz, D. Differentiation of resting human peripheral blood\u00a0\u03b3\u03b4\u00a0T cells toward Th1- or Th2-phenotype. Cell. Immunol. 212, 110\u2013117 (2001).","journal-title":"Cell. Immunol."},{"key":"1196_CR40","doi-asserted-by":"publisher","first-page":"12520","DOI":"10.1073\/pnas.1607136113","volume":"113","author":"C Peters","year":"2016","unstructured":"Peters, C., H\u00e4sler, R., Wesch, D. & Kabelitz, D. Human V\u03b42 T cells are a major source of interleukin-9. Proc. Natl Acad. Sci. USA 113, 12520\u201312525 (2016).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1196_CR41","doi-asserted-by":"publisher","first-page":"7268","DOI":"10.4049\/jimmunol.1000600","volume":"184","author":"KJ Ness-Schwickerat","year":"2010","unstructured":"Ness-Schwickerat, K. J., Jin, C. & Morita, C. T. Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human V\u03b32V\u03b42 T cells. J. Immunol. 184, 7268\u20137280 (2010).","journal-title":"J. Immunol."},{"key":"1196_CR42","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/ni.1717","volume":"10","author":"JC Ribot","year":"2009","unstructured":"Ribot, J. C. et al. CD27 is a thymic determinant of the balance between interferon-\u03b3- and interleukin 17-producing\u00a0\u03b3\u03b4\u00a0T cell subsets. Nat. Immunol. 10, 427\u2013436 (2009).","journal-title":"Nat. Immunol."},{"key":"1196_CR43","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s41590-024-02073-8","volume":"26","author":"D In\u00e1cio","year":"2025","unstructured":"In\u00e1cio, D. et al. Signature cytokine-associated transcriptome analysis of effector \u03b3\u03b4 T cells identifies subset-specific regulators of peripheral activation. Nat. Immunol. 26, 497\u2013510 (2025).","journal-title":"Nat. Immunol."},{"key":"1196_CR44","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.chom.2010.01.005","volume":"7","author":"J Duan","year":"2010","unstructured":"Duan, J., Chung, H., Troy, E. & Kasper, D. L. Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17-producing \u03b3\/\u03b4 T cells. Cell Host Microbe 7, 140\u2013150 (2010).","journal-title":"Cell Host Microbe"},{"key":"1196_CR45","doi-asserted-by":"publisher","first-page":"2237","DOI":"10.4049\/jimmunol.1303119","volume":"192","author":"JC Ribot","year":"2014","unstructured":"Ribot, J. C., Ribeiro, S. T., Correia, D. V., Sousa, A. E. & Silva-Santos, B. Human \u03b3\u03b4 thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2\/IL-15 signaling. J. Immunol. 192, 2237\u20132243 (2014).","journal-title":"J. Immunol."},{"key":"1196_CR46","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s00262-019-02469-8","volume":"69","author":"K Schilbach","year":"2020","unstructured":"Schilbach, K. et al. Suppressive activity of V\u03b42+ \u03b3\u03b4 T cells on \u03b1\u03b2 T cells is licensed by TCR signaling and correlates with signal strength. Cancer Immunol. Immunother. 69, 593\u2013610 (2020).","journal-title":"Cancer Immunol. Immunother."},{"key":"1196_CR47","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1379642","volume":"7","author":"C Barjon","year":"2017","unstructured":"Barjon, C. et al. IL-21 promotes the development of a CD73-positive V\u03b39V\u03b42 T cell regulatory population. Oncoimmunology 7, e1379642 (2017).","journal-title":"Oncoimmunology"},{"key":"1196_CR48","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01733-x","volume":"22","author":"C Xia","year":"2023","unstructured":"Xia, C., Yin, S., To, K. K. W. & Fu, L. CD39\/CD73\/A2AR pathway and cancer immunotherapy. Mol. Cancer 22, 44 (2023).","journal-title":"Mol. Cancer"},{"key":"1196_CR49","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/cmi.2015.07","volume":"13","author":"Y Mao","year":"2016","unstructured":"Mao, Y. et al. A new effect of IL-4 on human \u03b3\u03b4 T cells: promoting regulatory V\u03b41 T cells via IL-10 production and inhibiting function of V\u03b42 T cells. Cell. Mol. Immunol. 13, 217\u2013228 (2016).","journal-title":"Cell. Mol. Immunol."},{"key":"1196_CR50","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.3389\/fimmu.2020.02186","volume":"11","author":"G Chabab","year":"2020","unstructured":"Chabab, G., Barjon, C., Bonnefoy, N. & Lafont, V. Pro-tumor \u03b3\u03b4 T cells in human cancer: polarization, mechanisms of action, and implications for therapy. Front. Immunol. 11, 2186 (2020).","journal-title":"Front. Immunol."},{"key":"1196_CR51","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1038\/s43018-023-00589-w","volume":"4","author":"C Harmon","year":"2023","unstructured":"Harmon, C. et al. \u03b3\u03b4 T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors. Nat. Cancer 4, 1122\u20131137 (2023).","journal-title":"Nat. Cancer"},{"key":"1196_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63572-w","volume":"10","author":"L Kouakanou","year":"2020","unstructured":"Kouakanou, L. et al. Vitamin C supports conversion of human \u03b3\u03b4 T cells into FOXP3-expressing regulatory cells by epigenetic regulation. Sci. Rep. 10, 6550 (2020).","journal-title":"Sci. Rep."},{"key":"1196_CR53","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","volume":"41","author":"KE de Visser","year":"2023","unstructured":"de Visser, K. E. & Joyce, J. A. The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth. Cancer Cell 41, 374\u2013403 (2023).","journal-title":"Cancer Cell"},{"key":"1196_CR54","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1126\/science.1063916","volume":"294","author":"M Girardi","year":"2001","unstructured":"Girardi, M. et al. Regulation of cutaneous malignancy by\u00a0\u03b3\u03b4\u00a0T cells. Science 294, 605\u2013609 (2001).","journal-title":"Science"},{"key":"1196_CR55","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1038\/s41423-020-0504-x","volume":"17","author":"D Kabelitz","year":"2020","unstructured":"Kabelitz, D., Serrano, R., Kouakanou, L., Peters, C. & Kalyan, S. Cancer immunotherapy with \u03b3\u03b4 T cells: many paths ahead of us. Cell. Mol. Immunol. 17, 925\u2013939 (2020).","journal-title":"Cell. Mol. Immunol."},{"key":"1196_CR56","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1038\/s41573-019-0038-z","volume":"19","author":"Z Sebestyen","year":"2020","unstructured":"Sebestyen, Z., Prinz, I., D\u00e9chanet-Merville, J., Silva-Santos, B. & Kuball, J. Translating gammadelta (\u03b3\u03b4) T cells and their receptors into cancer cell therapies. Nat. Rev. Drug Discov. 19, 169\u2013184 (2020).","journal-title":"Nat. Rev. Drug Discov."},{"key":"1196_CR57","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/s41571-022-00722-1","volume":"20","author":"S Mensurado","year":"2023","unstructured":"Mensurado, S., Blanco-Dom\u00ednguez, R. & Silva-Santos, B. The emerging roles of \u03b3\u03b4 T cells in cancer immunotherapy. Nat. Rev. Clin. Oncol. 20, 178\u2013191 (2023).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"1196_CR58","doi-asserted-by":"publisher","first-page":"eabq7248","DOI":"10.1126\/science.abq7248","volume":"386","author":"A Hayday","year":"2024","unstructured":"Hayday, A., Dechanet-Merville, J., Rossjohn, J. & Silva-Santos, B. Cancer immunotherapy by \u03b3\u03b4 T cells. Science 386, eabq7248 (2024).","journal-title":"Science"},{"key":"1196_CR59","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/s43018-024-00798-x","volume":"5","author":"M Arias-Badia","year":"2024","unstructured":"Arias-Badia, M., Chang, R. & Fong, L. \u03b3\u03b4 T cells as critical anti-tumor immune effectors. Nat. Cancer 5, 1145\u20131157 (2024).","journal-title":"Nat. Cancer"},{"key":"1196_CR60","doi-asserted-by":"publisher","first-page":"1562188","DOI":"10.3389\/fimmu.2025.1562188","volume":"16","author":"J Lv","year":"2025","unstructured":"Lv, J. et al. \u03b3\u03b4T cells, a key subset of T cell for cancer immunotherapy. Front. Immunol. 16, 1562188 (2025).","journal-title":"Front. Immunol."},{"key":"1196_CR61","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1038\/nm.3909","volume":"21","author":"AJ Gentles","year":"2015","unstructured":"Gentles, A. J. et al. The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat. Med. 21, 938\u2013945 (2015).","journal-title":"Nat. Med."},{"key":"1196_CR62","doi-asserted-by":"publisher","first-page":"eaax9364","DOI":"10.1126\/scitranslmed.aax9364","volume":"11","author":"Y Wu","year":"2019","unstructured":"Wu, Y. et al. An innate-like V\u03b41+ \u03b3\u03b4 T cell compartment in the human breast is associated with remission in triple-negative breast cancer. Sci. Transl. Med. 11, eaax9364 (2019).","journal-title":"Sci. Transl. Med."},{"key":"1196_CR63","doi-asserted-by":"publisher","first-page":"573920","DOI":"10.3389\/fimmu.2020.573920","volume":"11","author":"H Lu","year":"2020","unstructured":"Lu, H. et al. High abundance of intratumoral \u03b3\u03b4 T cells favors a better prognosis in head and neck squamous cell carcinoma: a bioinformatic analysis. Front. Immunol. 11, 573920 (2020).","journal-title":"Front. Immunol."},{"key":"1196_CR64","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/s43018-022-00376-z","volume":"3","author":"Y Wu","year":"2022","unstructured":"Wu, Y. et al. A local human V\u03b41 T cell population is associated with survival in nonsmall-cell lung cancer. Nat. Cancer 3, 696\u2013709 (2022).","journal-title":"Nat. Cancer"},{"key":"1196_CR65","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1353858","volume":"6","author":"J Wang","year":"2017","unstructured":"Wang, J. et al. Tumor-infiltrating \u03b3\u03b4T cells predict prognosis and adjuvant chemotherapeutic benefit in patients with gastric cancer. Oncoimmunology 6, e1353858 (2017).","journal-title":"Oncoimmunology"},{"key":"1196_CR66","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1158\/2326-6066.CIR-20-0817","volume":"9","author":"NA Gherardin","year":"2021","unstructured":"Gherardin, N. A. et al. \u03b3\u03b4 T cells in Merkel cell carcinomas have a proinflammatory profile prognostic of patient survival. Cancer Immunol. Res. 9, 612\u2013623 (2021).","journal-title":"Cancer Immunol. Res."},{"key":"1196_CR67","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-004880","volume":"10","author":"S Nguyen","year":"2022","unstructured":"Nguyen, S. et al. V\u03b42 T cells are associated with favorable clinical outcomes in patients with bladder cancer and their tumor reactivity can be boosted by BCG and zoledronate treatments. J. Immunother. Cancer 10, e004880 (2022).","journal-title":"J. Immunother. Cancer"},{"key":"1196_CR68","doi-asserted-by":"publisher","first-page":"5029","DOI":"10.4049\/jimmunol.1201892","volume":"189","author":"C Ma","year":"2012","unstructured":"Ma, C. et al. Tumor-infiltrating \u03b3\u03b4 T lymphocytes predict clinical outcome in human breast cancer. J. Immunol. 189, 5029\u20135036 (2012).","journal-title":"J. Immunol."},{"key":"1196_CR69","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.immuni.2014.03.013","volume":"40","author":"P Wu","year":"2014","unstructured":"Wu, P. et al. \u03b3\u03b4T17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer. Immunity 40, 785\u2013800 (2014).","journal-title":"Immunity"},{"key":"1196_CR70","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1002\/ijc.30134","volume":"139","author":"RS Patil","year":"2016","unstructured":"Patil, R. S. et al. IL17 producing \u03b3\u03b4T cells induce angiogenesis and are associated with poor survival in gallbladder cancer patients. Int. J. Cancer 139, 869\u2013881 (2016).","journal-title":"Int. J. Cancer"},{"key":"1196_CR71","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/s41423-024-01135-z","volume":"21","author":"Z Wu","year":"2024","unstructured":"Wu, Z. et al. Unsynchronized butyrophilin molecules dictate cancer cell evasion of V\u03b39V\u03b42 T-cell killing. Cell. Mol. Immunol. 21, 362\u2013373 (2024).","journal-title":"Cell. Mol. Immunol."},{"key":"1196_CR72","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/s41586-023-06482-x","volume":"621","author":"MR Mamedov","year":"2023","unstructured":"Mamedov, M. R. et al. CRISPR screens decode cancer cell pathways that trigger \u03b3\u03b4 T cell detection. Nature 621, 188\u2013195 (2023).","journal-title":"Nature"},{"key":"1196_CR73","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1084\/jem.20021500","volume":"197","author":"HJ Gober","year":"2003","unstructured":"Gober, H. J. et al. Human T cell receptor gammadelta cells recognize endogenous mevalonate metabolites in tumor cells. J. Exp. Med. 197, 163\u2013168 (2003).","journal-title":"J. Exp. Med."},{"key":"1196_CR74","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1007\/s00262-007-0279-2","volume":"56","author":"SR Mattarollo","year":"2007","unstructured":"Mattarollo, S. R., Kenna, T., Nieda, M. & Nicol, A. J. Chemotherapy and zoledronate sensitize solid tumour cells to V\u03b39V\u03b42 T cell cytotoxicity. Cancer Immunol. Immunother. 56, 1285\u20131297 (2007).","journal-title":"Cancer Immunol. Immunother."},{"key":"1196_CR75","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/j.1365-3083.2007.01963.x","volume":"66","author":"P Wrobel","year":"2007","unstructured":"Wrobel, P. et al. Lysis of a broad range of epithelial tumour cells by human\u00a0\u03b3\u03b4\u00a0T cells: involvement of NKG2D ligands and T-cell receptor- versus NKG2D-dependent recognition. Scand. J. Immunol. 66, 320\u2013328 (2007).","journal-title":"Scand. J. Immunol."},{"key":"1196_CR76","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1182\/blood.2023022992","volume":"143","author":"S Mensurado","year":"2024","unstructured":"Mensurado, S. et al. CD155\/PVR determines acute myeloid leukemia targeting by Delta One T cells. Blood 143, 1488\u20131495 (2024).","journal-title":"Blood"},{"key":"1196_CR77","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125884","volume":"4","author":"J Mikulak","year":"2019","unstructured":"Mikulak, J. et al. NKp46-expressing human gut-resident intraepithelial V\u03b41 T cell subpopulation exhibits high antitumor activity against colorectal cancer. JCI Insight 4, e125884 (2019).","journal-title":"JCI Insight"},{"key":"1196_CR78","doi-asserted-by":"publisher","first-page":"5795","DOI":"10.1158\/1078-0432.CCR-16-0597","volume":"22","author":"AR Almeida","year":"2016","unstructured":"Almeida, A. R. et al. Delta One T cells for immunotherapy of chronic lymphocytic leukemia: clinical-grade expansion\/differentiation and preclinical proof of concept. Clin. Cancer Res. 22, 5795\u20135804 (2016).","journal-title":"Clin. Cancer Res."},{"key":"1196_CR79","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/s43018-025-00948-9","volume":"6","author":"R Blanco-Dom\u00ednguez","year":"2025","unstructured":"Blanco-Dom\u00ednguez, R. et al. Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer. Nat. Cancer 6, 1056\u20131972 (2025).","journal-title":"Nat. Cancer"},{"key":"1196_CR80","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev-immunol-090222-100246","volume":"42","author":"A Lockhart","year":"2024","unstructured":"Lockhart, A., Mucida, D. & Bilate, A. M. Intraepithelial lymphocytes of the Intestine. Annu. Rev. Immunol. 42, 289\u2013316 (2024).","journal-title":"Annu. Rev. Immunol."},{"key":"1196_CR81","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/s41575-024-00906-3","volume":"21","author":"V Horn","year":"2024","unstructured":"Horn, V. & Sonnenberg, G. F. Group 3 innate lymphoid cells in intestinal health and disease. Nat. Rev. Gastroenterol. Hepatol. 21, 428\u2013443 (2024).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"1196_CR82","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.cell.2016.08.030","volume":"167","author":"R Di Marco Barros","year":"2016","unstructured":"Di Marco Barros, R. et al. Epithelia use butyrophilin-like molecules to shape organ-specific \u03b3\u03b4 T cell compartments. Cell\u00a0167, 203\u2013218 (2016).","journal-title":"Cell"},{"key":"1196_CR83","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/0008-8749(90)90053-T","volume":"128","author":"R Ullrich","year":"1990","unstructured":"Ullrich, R., Schieferdecker, H. L., Ziegler, K., Riecken, E. O. & Zeitz, M. gamma delta T cells in the human intestine express surface markers of activation and are preferentially located in the epithelium. Cell. Immunol. 128, 619-627 (1990)","journal-title":"Cell. Immunol."},{"key":"1196_CR84","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/s41421-023-00542-2","volume":"9","author":"J Han","year":"2023","unstructured":"Han, J. et al. TGF-\u03b2 controls development of TCR\u03b3\u03b4+CD8\u03b1\u03b1+ intestinal intraepithelial lymphocytes. Cell Discov. 9, 52 (2023).","journal-title":"Cell Discov."},{"key":"1196_CR85","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/imr.12916","volume":"298","author":"T Suzuki","year":"2020","unstructured":"Suzuki, T., Hayman, L., Kilbey, A., Edwards, J. & Coffelt, S. B. Gut \u03b3\u03b4 T cells as guardians, disruptors, and instigators of cancer. Immunol. Rev. 298, 198\u2013217 (2020).","journal-title":"Immunol. Rev."},{"key":"1196_CR86","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1053\/j.gastro.2006.06.003","volume":"131","author":"JE Dalton","year":"2006","unstructured":"Dalton, J. E. et al. Intraepithelial \u03b3\u03b4+\u00a0lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection. Gastroenterology 131, 818\u2013829 (2006).","journal-title":"Gastroenterology"},{"key":"1196_CR87","doi-asserted-by":"publisher","first-page":"8743","DOI":"10.1073\/pnas.1019574108","volume":"108","author":"AS Ismail","year":"2011","unstructured":"Ismail, A. S. et al.\u00a0\u03b3\u03b4\u00a0intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc. Natl Acad. Sci. USA 108, 8743\u20138748 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1196_CR88","doi-asserted-by":"publisher","first-page":"849954","DOI":"10.3389\/fimmu.2022.849954","volume":"13","author":"F Rampoldi","year":"2022","unstructured":"Rampoldi, F. & Prinz, I. Three layers of intestinal \u03b3\u03b4 T cells talk different languages with the microbiota. Front. Immunol. 13, 849954 (2022).","journal-title":"Front. Immunol."},{"key":"1196_CR89","doi-asserted-by":"publisher","first-page":"3378","DOI":"10.1002\/eji.201040727","volume":"40","author":"FH Malinarich","year":"2010","unstructured":"Malinarich, F. H. et al. Constant TCR triggering suggests that the TCR expressed on intestinal intraepithelial \u03b3\u03b4 T cells is functional in vivo. Eur. J. Immunol. 40, 3378\u20133388 (2010).","journal-title":"Eur. J. Immunol."},{"key":"1196_CR90","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/mi.2013.32","volume":"7","author":"TF Meehan","year":"2014","unstructured":"Meehan, T. F. et al. Protection against colitis by CD100-dependent modulation of intraepithelial \u03b3\u03b4 T lymphocyte function. Mucosal Immunol. 7, 134\u2013142 (2014).","journal-title":"Mucosal Immunol."},{"key":"1196_CR91","doi-asserted-by":"publisher","first-page":"14338","DOI":"10.1073\/pnas.212290499","volume":"99","author":"Y Chen","year":"2002","unstructured":"Chen, Y., Chou, K., Fuchs, E., Havran, W. L. & Boismenu, R. Protection of the intestinal mucosa by intraepithelial\u00a0\u03b3\u03b4\u00a0T cells. Proc. Natl Acad. Sci. USA 99, 14338\u201314343 (2002).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1196_CR92","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.1172\/JCI118002","volume":"95","author":"M Watanabe","year":"1995","unstructured":"Watanabe, M. et al. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J. Clin. Invest. 95, 2945\u20132953 (1995).","journal-title":"J. Clin. Invest."},{"key":"1196_CR93","doi-asserted-by":"publisher","first-page":"6180","DOI":"10.4049\/jimmunol.176.10.6180","volume":"176","author":"Q Yu","year":"2006","unstructured":"Yu, Q. et al. MyD88-dependent signaling for IL-15 production plays an important role in maintenance of CD8\u03b1\u03b1\u00a0TCR\u03b1\u03b2\u00a0and TCR\u03b3\u03b4\u00a0intestinal intraepithelial lymphocytes. J. Immunol. 176, 6180\u20136185 (2006).","journal-title":"J. Immunol."},{"key":"1196_CR94","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.cell.2011.09.025","volume":"147","author":"Y Li","year":"2011","unstructured":"Li, Y. et al. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 147, 629\u2013640 (2011).","journal-title":"Cell"},{"key":"1196_CR95","doi-asserted-by":"publisher","first-page":"eaba8310","DOI":"10.1126\/science.aba8310","volume":"371","author":"ZA Sullivan","year":"2021","unstructured":"Sullivan, Z. A. et al. \u03b3\u03b4 T cells regulate the intestinal response to nutrient sensing. Science 371, eaba8310 (2021).","journal-title":"Science"},{"key":"1196_CR96","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature13564","volume":"514","author":"X Wang","year":"2014","unstructured":"Wang, X. et al. Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes. Nature 514, 237\u2013241 (2014).","journal-title":"Nature"},{"key":"1196_CR97","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/nature16460","volume":"528","author":"CA Lindemans","year":"2015","unstructured":"Lindemans, C. A. et al. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature 528, 560\u2013564 (2015).","journal-title":"Nature"},{"key":"1196_CR98","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51209-9","volume":"15","author":"B Xie","year":"2024","unstructured":"Xie, B. et al. Gut-derived memory \u03b3\u03b4 T17 cells exacerbate sepsis-induced acute lung injury in mice. Nat. Commun. 15, 6737 (2024).","journal-title":"Nat. Commun."},{"key":"1196_CR99","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s41590-023-01447-8","volume":"24","author":"X Zhu","year":"2023","unstructured":"Zhu, X. et al. Dectin-1 signaling on colonic \u03b3\u03b4 T cells promotes psychosocial stress responses. Nat. Immunol. 24, 625\u2013636 (2023).","journal-title":"Nat. Immunol."},{"key":"1196_CR100","doi-asserted-by":"publisher","first-page":"1206299","DOI":"10.3389\/fimmu.2023.1206299","volume":"14","author":"GQ Li","year":"2023","unstructured":"Li, G. Q. et al. The intestinal \u03b3\u03b4 T cells: functions in the gut and in the distant organs. Front. Immunol. 14, 1206299 (2023).","journal-title":"Front. Immunol."},{"key":"1196_CR101","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.4049\/jimmunol.1202959","volume":"191","author":"NE McCarthy","year":"2013","unstructured":"McCarthy, N. E. et al. Proinflammatory V\u03b42+ T cells populate the human intestinal mucosa and enhance IFN-\u03b3 production by colonic \u03b1\u03b2 T cells. J. Immunol. 191, 2752\u20132763 (2013).","journal-title":"J. Immunol."},{"key":"1196_CR102","doi-asserted-by":"publisher","first-page":"5527","DOI":"10.1073\/pnas.86.14.5527","volume":"86","author":"S Kyes","year":"1989","unstructured":"Kyes, S., Carew, E., Carding, S. R., Janeway, C. A. Jr. & Hayday, A. Diversity in T-cell receptor gamma gene usage in intestinal epithelium. Proc. Natl Acad. Sci. USA 86, 5527\u20135531 (1989).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1196_CR103","doi-asserted-by":"publisher","first-page":"4376","DOI":"10.1073\/pnas.1010647108","volume":"108","author":"A Bas","year":"2011","unstructured":"Bas, A. et al. Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes. Proc. Natl Acad. Sci. USA 108, 4376\u20134381 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1196_CR104","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1038\/s41590-018-0253-5","volume":"19","author":"D Melandri","year":"2018","unstructured":"Melandri, D. et al. The \u03b3\u03b4TCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness. Nat. Immunol. 19, 1352\u20131365 (2018).","journal-title":"Nat. Immunol."},{"key":"1196_CR105","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17557-y","volume":"11","author":"A Jandke","year":"2020","unstructured":"Jandke, A. et al. Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial \u03b3\u03b4 T cell compartments. Nat. Commun. 11, 3769 (2020).","journal-title":"Nat. Commun."},{"key":"1196_CR106","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/s42003-021-02438-x","volume":"4","author":"C Panea","year":"2021","unstructured":"Panea, C. et al. Butyrophilin-like 2 regulates site-specific adaptations of intestinal \u03b3\u03b4 intraepithelial lymphocytes. Commun. Biol. 4, 913 (2021).","journal-title":"Commun. Biol."},{"key":"1196_CR107","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.immuni.2019.09.006","volume":"51","author":"CR Willcox","year":"2019","unstructured":"Willcox, C. R. et al. Butyrophilin-like 3 directly binds a human V\u03b34+ T cell receptor using a modality distinct from clonally-restricted antigen. Immunity 51, 813\u2013825 (2019).","journal-title":"Immunity"},{"key":"1196_CR108","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/s41590-021-01124-8","volume":"23","author":"DR McKenzie","year":"2022","unstructured":"McKenzie, D. R. et al. Normality sensing licenses local T cells for innate-like tissue surveillance. Nat. Immunol. 23, 411\u2013422 (2022).","journal-title":"Nat. Immunol."},{"key":"1196_CR109","doi-asserted-by":"publisher","first-page":"eadh0301","DOI":"10.1126\/science.adh0301","volume":"381","author":"RJ Dart","year":"2023","unstructured":"Dart, R. J. et al. Conserved \u03b3\u03b4 T cell selection by BTNL proteins limits progression of human inflammatory bowel disease. Science 381, eadh0301 (2023).","journal-title":"Science"},{"key":"1196_CR110","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2110288118","volume":"118","author":"MT Rice","year":"2021","unstructured":"Rice, M. T. et al. Recognition of the antigen-presenting molecule MR1 by a V\u03b43+ \u03b3\u03b4 T cell receptor. Proc. Natl Acad. Sci. USA 118, e2110288118 (2021).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1196_CR111","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31443-9","volume":"13","author":"M Wegrecki","year":"2022","unstructured":"Wegrecki, M. et al. Atypical sideways recognition of CD1a by autoreactive \u03b3\u03b4 T cell receptors. Nat. Commun. 13, 3872 (2022).","journal-title":"Nat. Commun."},{"key":"1196_CR112","doi-asserted-by":"publisher","first-page":"22944","DOI":"10.1073\/pnas.2010545117","volume":"117","author":"JF Reijneveld","year":"2020","unstructured":"Reijneveld, J. F. et al. Human \u03b3\u03b4 T cells recognize CD1b by two distinct mechanisms. Proc. Natl Acad. Sci. USA 117, 22944\u201322952 (2020).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1196_CR113","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1136\/gutjnl-2022-327736","volume":"72","author":"E Morgan","year":"2023","unstructured":"Morgan, E. et al. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut 72, 338\u2013344 (2023).","journal-title":"Gut"},{"key":"1196_CR114","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.1126\/science.1129139","volume":"313","author":"J Galon","year":"2006","unstructured":"Galon, J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960\u20131964 (2006).","journal-title":"Science"},{"key":"1196_CR115","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1200\/JCO.2017.76.9901","volume":"36","author":"MJ Overman","year":"2018","unstructured":"Overman, M. J. et al. Durable clinical benefit with nivolumab plus ipilimumab in DNA mismatch repair-deficient\/microsatellite instability-high metastatic colorectal cancer. J. Clin. Oncol. 36, 773\u2013779 (2018).","journal-title":"J. Clin. Oncol."},{"key":"1196_CR116","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/nature24673","volume":"552","author":"G Germano","year":"2017","unstructured":"Germano, G. et al. Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth. Nature 552, 116\u2013120 (2017).","journal-title":"Nature"},{"key":"1196_CR117","doi-asserted-by":"publisher","first-page":"5090","DOI":"10.3390\/cancers15205090","volume":"15","author":"R Heregger","year":"2023","unstructured":"Heregger, R. et al. Unraveling resistance to immunotherapy in MSI-high colorectal cancer. Cancers 15, 5090 (2023).","journal-title":"Cancers"},{"key":"1196_CR118","doi-asserted-by":"publisher","first-page":"5481","DOI":"10.4049\/jimmunol.175.8.5481","volume":"175","author":"M Corvaisier","year":"2005","unstructured":"Corvaisier, M. et al. V\u03b39V\u03b42 T cell response to colon carcinoma cells. J. Immunol. 175, 5481\u20135488 (2005).","journal-title":"J. Immunol."},{"key":"1196_CR119","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1084\/jem.183.4.1681","volume":"183","author":"MJ Maeurer","year":"1996","unstructured":"Maeurer, M. J. et al. Human intestinal Vdelta1 + lymphocytes recognize tumor cells of epithelial origin. J. Exp. Med. 183, 1681\u20131696 (1996).","journal-title":"J. Exp. Med."},{"key":"1196_CR120","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1084\/jem.20041851","volume":"201","author":"F Halary","year":"2005","unstructured":"Halary, F. et al. Shared reactivity of V\u03b42neg \u03b3\u03b4 T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells. J. Exp. Med. 201, 1567\u20131578 (2005).","journal-title":"J. Exp. Med."},{"key":"1196_CR121","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1136\/gutjnl-2019-318672","volume":"69","author":"NL de Vries","year":"2020","unstructured":"de Vries, N. L. et al. High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity. Gut 69, 691\u2013703 (2020).","journal-title":"Gut"},{"key":"1196_CR122","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1347742","volume":"6","author":"S Meraviglia","year":"2017","unstructured":"Meraviglia, S. et al. Distinctive features of tumor-infiltrating \u03b3\u03b4 T lymphocytes in human colorectal cancer. Oncoimmunology 6, e1347742 (2017).","journal-title":"Oncoimmunology"},{"key":"1196_CR123","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.3748\/wjg.v22.i13.3573","volume":"22","author":"L Rong","year":"2016","unstructured":"Rong, L. et al. Analysis of tumor-infiltrating gamma delta T cells in rectal cancer. World J. Gastroenterol. 22, 3573\u20133580 (2016).","journal-title":"World J. Gastroenterol."},{"key":"1196_CR124","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1007\/s00262-024-03758-7","volume":"73","author":"W Rodin","year":"2024","unstructured":"Rodin, W. et al. \u03b3\u03b4 T cells in human colon adenocarcinomas comprise mainly V\u03b41, V\u03b42, and V\u03b43 cells with distinct phenotype and function. Cancer Immunol. Immunother. 73, 174 (2024).","journal-title":"Cancer Immunol. Immunother."},{"key":"1196_CR125","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.3390\/cells9061537","volume":"9","author":"G Chabab","year":"2020","unstructured":"Chabab, G. et al. Diversity of tumor-infiltrating, \u03b3\u03b4 T-cell abundance in solid cancers. Cells 9, 1537 (2020).","journal-title":"Cells"},{"key":"1196_CR126","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1002\/ijc.34669","volume":"153","author":"L Yu","year":"2023","unstructured":"Yu, L. et al. Tumor-infiltrating gamma delta T-cells reveal exhausted subsets with remarkable heterogeneity in colorectal cancer. Int. J. Cancer 153, 1684\u20131697 (2023).","journal-title":"Int. J. Cancer"},{"key":"1196_CR127","doi-asserted-by":"publisher","first-page":"2532231","DOI":"10.1080\/2162402X.2025.2532231","volume":"14","author":"H Karjalainen","year":"2025","unstructured":"Karjalainen, H. et al. Characteristics and significance of \u03b3\u03b4 T cells in colorectal cancer. Oncoimmunology 14, 2532231 (2025).","journal-title":"Oncoimmunology"},{"key":"1196_CR128","doi-asserted-by":"publisher","first-page":"eadf2163","DOI":"10.1126\/sciimmunol.adf2163","volume":"8","author":"MH Yakou","year":"2023","unstructured":"Yakou, M. H. et al. TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma. Sci. Immunol. 8, eadf2163 (2023).","journal-title":"Sci. Immunol."},{"key":"1196_CR129","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51025-1","volume":"15","author":"V Stary","year":"2024","unstructured":"Stary, V. et al. Dysfunctional tumor-infiltrating V\u03b41 + T lymphocytes in microsatellite-stable colorectal cancer. Nat. Commun. 15, 6949 (2024).","journal-title":"Nat. Commun."},{"key":"1196_CR130","doi-asserted-by":"publisher","first-page":"111719","DOI":"10.1016\/j.yexcr.2019.111719","volume":"386","author":"X Li","year":"2010","unstructured":"Li, X. et al. Tim-3 suppresses the killing effect of V\u03b39V\u03b42 T cells on colon cancer cells by reducing perforin and granzyme B expression. Exp. Cell Res. 386, 111719 (2010).","journal-title":"Exp. Cell Res."},{"key":"1196_CR131","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1084\/jem.20062512","volume":"204","author":"S Deaglio","year":"2007","unstructured":"Deaglio, S. et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204, 1257\u20131265 (2007).","journal-title":"J. Exp. Med."},{"key":"1196_CR132","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1277305","volume":"6","author":"G Hu","year":"2017","unstructured":"Hu, G. et al. Tumor-infiltrating CD39+\u03b3\u03b4 Tregs are novel immunosuppressive T cells in human colorectal cancer. Oncoimmunology 6, e1277305 (2017).","journal-title":"Oncoimmunology"},{"key":"1196_CR133","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1245\/s10434-019-07209-x","volume":"26","author":"D Shida","year":"2019","unstructured":"Shida, D. et al. Prognostic value of primary tumor sidedness for unresectable stage IV colorectal cancer: a retrospective study. Ann. Surg. Oncol. 26, 1358\u20131365 (2019).","journal-title":"Ann. Surg. Oncol."},{"key":"1196_CR134","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.148028","volume":"6","author":"Y Zhan","year":"2021","unstructured":"Zhan, Y. et al. PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39 + \u03b3\u03b4 Treg polarization. JCI Insight 6, e148028 (2021).","journal-title":"JCI Insight"},{"key":"1196_CR135","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1158\/2326-6066.CIR-22-0644","volume":"11","author":"T Suzuki","year":"2023","unstructured":"Suzuki, T. et al. \u03b2-Catenin drives butyrophilin-like molecule loss and \u03b3\u03b4 T-cell exclusion in colon cancer. Cancer Immunol. Res. 11, 1137\u20131155 (2023).","journal-title":"Cancer Immunol. Res."},{"key":"1196_CR136","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41577-021-00563-6","volume":"22","author":"X Zhao","year":"2022","unstructured":"Zhao, X., Shan, Q. & Xue, H. H. TCF1 in T cell immunity: a broadened frontier. Nat. Rev. Immunol. 22, 147\u2013157 (2022).","journal-title":"Nat. Rev. Immunol."},{"key":"1196_CR137","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1016\/j.immuni.2014.11.009","volume":"41","author":"K Wang","year":"2014","unstructured":"Wang, K. et al. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity 41, 1052\u20131063 (2014).","journal-title":"Immunity"},{"key":"1196_CR138","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nature14282","volume":"522","author":"SB Coffelt","year":"2015","unstructured":"Coffelt, S. B. et al. IL-17-producing \u03b3\u03b4 T cells and neutrophils conspire to promote breast cancer metastasis. Nature 522, 345\u2013348 (2015).","journal-title":"Nature"},{"key":"1196_CR139","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1158\/0008-5472.CAN-13-2534","volume":"74","author":"S Ma","year":"2014","unstructured":"Ma, S. et al. IL-17A produced by \u03b3\u03b4 T cells promotes tumor growth in hepatocellular carcinoma. Cancer Res. 74, 1969\u20131982 (2014).","journal-title":"Cancer Res."},{"key":"1196_CR140","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1038\/nm.2015","volume":"15","author":"S Wu","year":"2009","unstructured":"Wu, S. et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat. Med. 15, 1016\u20131022 (2009).","journal-title":"Nat. Med."},{"key":"1196_CR141","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1158\/0008-5472.CAN-15-0749","volume":"76","author":"F Housseau","year":"2016","unstructured":"Housseau, F. et al. Redundant innate and adaptive sources of IL17 production drive colon tumorigenesis. Cancer Res. 76, 2115\u20132124 (2016).","journal-title":"Cancer Res."},{"key":"1196_CR142","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.cell.2018.12.040","volume":"176","author":"C Jin","year":"2019","unstructured":"Jin, C. et al. Commensal microbiota promote lung cancer development via \u03b3\u03b4 T cells. Cell 176, 998\u20131013 (2019).","journal-title":"Cell"},{"key":"1196_CR143","doi-asserted-by":"publisher","first-page":"bgae079","DOI":"10.1093\/carcin\/bgae079","volume":"46","author":"E Begagic","year":"2025","unstructured":"Begagic, E., Vranic, S. & Sominanda, A. The role of interleukin 17 in cancer: a systematic review. Carcinogenesis 46, bgae079 (2025).","journal-title":"Carcinogenesis"},{"key":"1196_CR144","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1126\/science.abj8695","volume":"377","author":"BS Reis","year":"2022","unstructured":"Reis, B. S. et al. TCR-V\u03b3\u03b4 usage distinguishes protumor from antitumor intestinal \u03b3\u03b4 T cell subsets. Science 377, 276\u2013284 (2022).","journal-title":"Science"},{"key":"1196_CR145","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1136\/gutjnl-2015-310016","volume":"66","author":"F Amicarella","year":"2017","unstructured":"Amicarella, F. et al. Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer. Gut 66, 692\u2013704 (2017).","journal-title":"Gut"},{"key":"1196_CR146","doi-asserted-by":"publisher","first-page":"101072","DOI":"10.1016\/j.neo.2024.101072","volume":"58","author":"R Ran","year":"2024","unstructured":"Ran, R., Trapecar, M. & Brubaker, D. K. Systematic analysis of human colorectal cancer scRNA-seq revealed limited pro-tumoral IL-17 production potential in gamma delta T cells. Neoplasia 58, 101072 (2024).","journal-title":"Neoplasia"},{"key":"1196_CR147","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.it.2024.05.008","volume":"45","author":"AY Yang","year":"2024","unstructured":"Yang, A. Y., Wistuba-Hamprecht, K., Greten, T. F. & Ruf, B. Innate-like T cells in liver disease. Trends Immunol. 45, 535\u2013548 (2024).","journal-title":"Trends Immunol."},{"key":"1196_CR148","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/hep.22034","volume":"47","author":"B Gao","year":"2008","unstructured":"Gao, B., Jeong, W. I. & Tian, Z. Liver: an organ with predominant innate immunity. Hepatology 47, 729\u2013736 (2008).","journal-title":"Hepatology"},{"key":"1196_CR149","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/ni.2691","volume":"14","author":"CN Jenne","year":"2013","unstructured":"Jenne, C. N. & Kubes, P. Immune surveillance by the liver. Nat. Immunol. 14, 996\u20131006 (2013).","journal-title":"Nat. Immunol."},{"key":"1196_CR150","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1038\/s41423-021-00656-1","volume":"18","author":"Y Hu","year":"2021","unstructured":"Hu, Y. et al. Single-cell analysis reveals the origins and intrahepatic development of liver-resident IFN-\u03b3-producing \u03b3\u03b4 T cells. Cell. Mol. Immunol. 18, 954\u2013968 (2021).","journal-title":"Cell. Mol. Immunol."},{"key":"1196_CR151","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S0168-8278(98)80206-7","volume":"28","author":"S Norris","year":"1998","unstructured":"Norris, S. et al. Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes. J. Hepatol. 28, 84\u201390 (1998).","journal-title":"J. Hepatol."},{"key":"1196_CR152","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.jhep.2018.05.007","volume":"69","author":"S Hunter","year":"2018","unstructured":"Hunter, S. et al. Human liver infiltrating \u03b3\u03b4 T cells are composed of clonally expanded circulating and tissue-resident populations. J. Hepatol. 69, 654\u2013665 (2018).","journal-title":"J. Hepatol."},{"key":"1196_CR153","doi-asserted-by":"publisher","first-page":"30","DOI":"10.4049\/jimmunol.1300121","volume":"191","author":"BA Mangan","year":"2013","unstructured":"Mangan, B. A. et al. Cutting edge: CD1d restriction and Th1\/Th2\/Th17 cytokine secretion by human V\u03b43 T cells. J. Immunol. 191, 30\u201334 (2013).","journal-title":"J. Immunol."},{"key":"1196_CR154","doi-asserted-by":"publisher","first-page":"619872","DOI":"10.3389\/fimmu.2020.619872","volume":"11","author":"W Hou","year":"2021","unstructured":"Hou, W. & Wu, X. Diverse functions of \u03b3\u03b4 T cells in the progression of hepatitis B virus and hepatitis C virus infection. Front. Immunol. 11, 619872 (2021).","journal-title":"Front. Immunol."},{"key":"1196_CR155","doi-asserted-by":"publisher","first-page":"100812","DOI":"10.1016\/j.jhepr.2023.100812","volume":"5","author":"O Ibidapo-Obe","year":"2023","unstructured":"Ibidapo-Obe, O. & Bruns, T. Tissue-resident and innate-like T cells in patients with advanced chronic liver disease. JHEP Rep. 5, 100812 (2023).","journal-title":"JHEP Rep."},{"key":"1196_CR156","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/BF03401834","volume":"7","author":"C Agrati","year":"2001","unstructured":"Agrati, C. et al. V\u03b41 T lymphocytes expressing a Th1 phenotype are the major\u00a0\u03b3\u03b4\u00a0T cell subset infiltrating the liver of HCV-infected persons. Mol. Med. 7, 11\u201319 (2001).","journal-title":"Mol. Med."},{"key":"1196_CR157","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1093\/infdis\/jit312","volume":"208","author":"X Wu","year":"2013","unstructured":"Wu, X. et al. Decreased V\u03b42 \u03b3\u03b4 T cells associated with liver damage by regulation of Th17 response in patients with chronic hepatitis B. J. Infect. Dis. 208, 1294\u20131304 (2013).","journal-title":"J. Infect. Dis."},{"key":"1196_CR158","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s12072-021-10267-7","volume":"16","author":"S Chen","year":"2022","unstructured":"Chen, S. et al. Reciprocal alterations in circulating and hepatic gamma-delta T cells in patients with primary biliary cholangitis. Hepatol. Int. 16, 195\u2013206 (2022).","journal-title":"Hepatol. Int."},{"key":"1196_CR159","doi-asserted-by":"publisher","first-page":"16018","DOI":"10.1038\/nrdp.2016.18","volume":"2","author":"JM Llovet","year":"2016","unstructured":"Llovet, J. M. et al. Hepatocellular carcinoma. Nat. Rev. Dis. Primers 2, 16018 (2016).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"1196_CR160","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/s41575-021-00438-0","volume":"18","author":"B Sangro","year":"2021","unstructured":"Sangro, B., Sarobe, P., Herv\u00e1s-Stubbs, S. & Melero, I. Advances in immunotherapy for hepatocellular carcinoma. Nat. Rev. Gastroenterol. Hepatol. 18, 525\u2013543 (2021).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"1196_CR161","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jcmgh.2019.08.004","volume":"9","author":"D Di Blasi","year":"2020","unstructured":"Di Blasi, D. et al. Unique T-cell populations define immune-inflamed hepatocellular carcinoma. Cell. Mol. Gastroenterol. Hepatol. 9, 195\u2013218 (2020).","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"1196_CR162","doi-asserted-by":"publisher","first-page":"775","DOI":"10.7314\/APJCP.2014.15.2.775","volume":"15","author":"XY Cai","year":"2014","unstructured":"Cai, X. Y. et al. Low counts of \u03b3\u03b4 T cells in peritumoral liver tissue are related to more frequent recurrence in patients with hepatocellular carcinoma after curative resection. Asian Pac. J. Cancer Prev. 15, 775\u2013780 (2014).","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"1196_CR163","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1002\/hep.31412","volume":"73","author":"N Zhao","year":"2021","unstructured":"Zhao, N. et al. Intratumoral \u03b3\u03b4 T-cell infiltrates, chemokine (C-C motif) ligand 4\/chemokine (C-C motif) ligand 5 protein expression and survival in patients with hepatocellular carcinoma. Hepatology 73, 1045\u20131060 (2021).","journal-title":"Hepatology"},{"key":"1196_CR164","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29012-1","volume":"13","author":"N Zakeri","year":"2022","unstructured":"Zakeri, N. et al. Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma. Nat. Commun. 13, 1372 (2022).","journal-title":"Nat. Commun."},{"key":"1196_CR165","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.intimp.2019.02.019","volume":"70","author":"H Jiang","year":"2019","unstructured":"Jiang, H. et al. \u03b3\u03b4 T cells in hepatocellular carcinoma patients present cytotoxic activity but are reduced in potency due to IL-2 and IL-21 pathways. Int. Immunopharmacol. 70, 167\u2013173 (2019).","journal-title":"Int. Immunopharmacol."},{"key":"1196_CR166","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.jhep.2012.12.015","volume":"58","author":"Y Yi","year":"2013","unstructured":"Yi, Y. et al. The functional impairment of HCC-infiltrating \u03b3\u03b4 T cells, partially mediated by regulatory T cells in a TGF\u03b2- and IL-10-dependent manner. J. Hepatol. 58, 977\u2013983 (2013).","journal-title":"J. Hepatol."},{"key":"1196_CR167","doi-asserted-by":"publisher","first-page":"1451650","DOI":"10.3389\/fonc.2024.1451650","volume":"14","author":"J Xia","year":"2024","unstructured":"Xia, J., Wang, C. & Li, B. Hepatocellular carcinoma cells induce \u03b3\u03b4 T cells through metabolic reprogramming into tumor-progressive subpopulation. Front. Oncol. 14, 1451650 (2024).","journal-title":"Front. Oncol."},{"key":"1196_CR168","doi-asserted-by":"publisher","first-page":"845974","DOI":"10.3389\/fimmu.2022.845974","volume":"13","author":"Y Hu","year":"2022","unstructured":"Hu, Y. et al. Apoptosis, pyroptosis, and ferroptosis conspiringly induce immunosuppressive hepatocellular carcinoma microenvironment and \u03b3\u03b4 T-cell imbalance. Front. Immunol. 13, 845974 (2022).","journal-title":"Front. Immunol."},{"key":"1196_CR169","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.800","volume":"12","author":"W He","year":"2022","unstructured":"He, W. et al. Hepatocellular carcinoma-infiltrating \u03b3\u03b4 T cells are functionally defected and allogenic V\u03b42+ \u03b3\u03b4 T cell can be a promising complement. Clin. Transl. Med. 12, e800 (2022).","journal-title":"Clin. Transl. Med."},{"key":"1196_CR170","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.molimm.2024.06.006","volume":"172","author":"H You","year":"2024","unstructured":"You, H. et al. CD69+ V\u03b41\u03b3\u03b4 T cells are anti-tumor subpopulations in hepatocellular carcinoma. Mol. Immunol. 172, 76\u201384 (2024).","journal-title":"Mol. Immunol."},{"key":"1196_CR171","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-004579","volume":"10","author":"E Bruni","year":"2022","unstructured":"Bruni, E. et al. Intrahepatic CD69+V\u03b41 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression. J. Immunother. Cancer 10, e004579 (2022).","journal-title":"J. Immunother. Cancer"},{"key":"1196_CR172","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1186\/s40425-019-0825-4","volume":"7","author":"E Bruni","year":"2019","unstructured":"Bruni, E. et al. Chemotherapy accelerates immune-senescence and functional impairments of V\u03b42pos T cells in elderly patients affected by liver metastatic colorectal cancer. J. Immunother. Cancer 7, 347 (2019).","journal-title":"J. Immunother. Cancer"},{"key":"1196_CR173","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1182\/blood-2017-08-752162","volume":"131","author":"R Handgretinger","year":"2018","unstructured":"Handgretinger, R. & Schilbach, K. The potential role of \u03b3\u03b4 T cells after allogeneic HCT for leukemia. Blood 131, 1063\u20131072 (2018).","journal-title":"Blood"},{"key":"1196_CR174","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/s41423-020-0515-7","volume":"18","author":"Y Xu","year":"2021","unstructured":"Xu, Y. et al. Allogeneic V\u03b39V\u03b42 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer. Cell. Mol. Immunol. 18, 427\u2013439 (2021).","journal-title":"Cell. Mol. Immunol."},{"key":"1196_CR175","doi-asserted-by":"publisher","first-page":"915837","DOI":"10.3389\/fimmu.2022.915837","volume":"13","author":"J Saura-Esteller","year":"2022","unstructured":"Saura-Esteller, J. et al. Gamma delta T-cell based cancer immunotherapy: past-present-future. Front. Immunol. 13, 915837 (2022).","journal-title":"Front. Immunol."},{"key":"1196_CR176","doi-asserted-by":"publisher","DOI":"10.4161\/2162402X.2014.992749","volume":"4","author":"D Wu","year":"2015","unstructured":"Wu, D. et al. Ex vivo expanded human circulating V\u03b41 \u03b3\u03b4T cells exhibit favorable therapeutic potential for colon cancer. Oncoimmunology 4, e992749 (2015).","journal-title":"Oncoimmunology"},{"key":"1196_CR177","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1007\/s00262-013-1402-1","volume":"62","author":"C Devaud","year":"2013","unstructured":"Devaud, C. et al. Anti-metastatic potential of human V\u03b41+ \u03b3\u03b4 T cells in an orthotopic mouse xenograft model of colon carcinoma. Cancer Immunol. Immunother. 62, 1199\u20131210 (2013).","journal-title":"Cancer Immunol. Immunother."},{"key":"1196_CR178","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s13045-016-0329-3","volume":"9","author":"HH Van Acker","year":"2016","unstructured":"Van Acker, H. H. et al. Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells. J. Hematol. Oncol. 9, 101 (2016).","journal-title":"J. Hematol. Oncol."},{"key":"1196_CR179","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.3389\/fimmu.2020.01868","volume":"11","author":"P Aehnlich","year":"2020","unstructured":"Aehnlich, P., Carnaz Sim\u00f5es, A. M., Skadborg, S. K., Holmen Olofsson, G. & Thor Straten, P. Expansion with IL-15 increases cytotoxicity of V\u03b39V\u03b42 T cells and is associated with higher levels of cytotoxic molecules and T-bet. Front. Immunol. 11, 1868 (2020).","journal-title":"Front. Immunol."},{"key":"1196_CR180","doi-asserted-by":"publisher","first-page":"eadg9814","DOI":"10.1126\/scitranslmed.adg9814","volume":"16","author":"D Fowler","year":"2024","unstructured":"Fowler, D. et al. Payload-delivering engineered \u03b3\u03b4 T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma. Sci. Transl. Med. 16, eadg9814 (2024).","journal-title":"Sci. Transl. Med."},{"key":"1196_CR181","doi-asserted-by":"publisher","first-page":"4415","DOI":"10.1158\/0008-5472.CAN-25-1890","volume":"85","author":"CB Nattress","year":"2025","unstructured":"Nattress, C. B. et al. Phenoscaping reveals multimodal \u03b3\u03b4 T cell cytotoxicity as a strategy to overcome cancer cell-mediated immunomodulation. Cancer Res. 85, 4415\u20134432 (2025).","journal-title":"Cancer Res."},{"key":"1196_CR182","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/s41423-019-0247-8","volume":"17","author":"L Kouakanou","year":"2020","unstructured":"Kouakanou, L. et al. Vitamin C promotes the proliferation and effector functions of human \u03b3\u03b4 T cells. Cell. Mol. Immunol. 17, 462\u2013473 (2020).","journal-title":"Cell. Mol. Immunol."},{"key":"1196_CR183","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/s41587-024-02446-2","volume":"43","author":"U Uslu","year":"2025","unstructured":"Uslu, U. & June, C. H. Beyond the blood: expanding CAR T cell therapy to solid tumors. Nat. Biotechnol. 43, 506\u2013515 (2025).","journal-title":"Nat. Biotechnol."},{"key":"1196_CR184","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1158\/1078-0432.CCR-23-3495","volume":"20","author":"P Thomas","year":"2024","unstructured":"Thomas, P., Paris, P. & Pecqueur, C. Arming V\u03b42 T cells with chimeric antigen receptors to combat cancer. Clin. Cancer Res. 20, 3105\u20133116 (2024).","journal-title":"Clin. Cancer Res."},{"key":"1196_CR185","first-page":"79","volume":"11","author":"X Zhai","year":"2021","unstructured":"Zhai, X. et al. MUC1-Tn-targeting chimeric antigen receptor-modified V\u03b39V\u03b42 T cells with enhanced antigen-specific anti-tumor activity. Am. J. Cancer Res. 11, 79\u201391 (2021).","journal-title":"Am. J. Cancer Res."},{"key":"1196_CR186","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003441","volume":"9","author":"A Makkouk","year":"2021","unstructured":"Makkouk, A. et al. Off-the-shelf V\u03b41 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against hepatocellular carcinoma. J. Immunother. Cancer 9, e003441 (2021).","journal-title":"J. Immunother. Cancer"},{"key":"1196_CR187","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1158\/2326-6066.CIR-16-0362","volume":"6","author":"MS Magee","year":"2018","unstructured":"Magee, M. S. et al. Human GUCY2C-targeted chimeric antigen receptor (CAR)-expressing T cells eliminate colorectal cancer metastases. Cancer Immunol. Res. 6, 509\u2013516 (2018).","journal-title":"Cancer Immunol. Res."},{"key":"1196_CR188","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1007\/s10238-022-00967-1","volume":"23","author":"M Li","year":"2023","unstructured":"Li, M. et al. CD318 is a target of chimeric antigen receptor T cells for the treatment of colorectal cancer. Clin. Exp. Med. 23, 2409\u20132419 (2023).","journal-title":"Clin. Exp. Med."},{"key":"1196_CR189","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1375641","volume":"7","author":"RCG de Bruin","year":"2017","unstructured":"de Bruin, R. C. G. et al. A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of V\u03b39V\u03b42-T cells. Oncoimmunology 7, e1375641 (2017).","journal-title":"Oncoimmunology"},{"key":"1196_CR190","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003850","volume":"9","author":"E van Diest","year":"2021","unstructured":"van Diest, E. et al. Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds. J. Immunother. Cancer 9, e003850 (2021).","journal-title":"J. Immunother. Cancer"},{"key":"1196_CR191","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1182\/blood-2010-12-325993","volume":"118","author":"V Marcu-Malina","year":"2011","unstructured":"Marcu-Malina, V. et al. Redirecting \u03b1\u03b2 T cells against cancer cells by transfer of a broadly tumor-reactive \u03b3\u03b4T-cell receptor. Blood 118, 50\u201359 (2011).","journal-title":"Blood"},{"key":"1196_CR192","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.3389\/fimmu.2018.01062","volume":"9","author":"T Straetemans","year":"2018","unstructured":"Straetemans, T. et al. GMP-grade manufacturing of T cells engineered to express a defined \u03b3\u03b4TCR. Front. Immunol. 9, 1062 (2018).","journal-title":"Front. Immunol."},{"key":"1196_CR193","doi-asserted-by":"publisher","first-page":"1159337","DOI":"10.3389\/fimmu.2023.1159337","volume":"14","author":"AD Meringa","year":"2023","unstructured":"Meringa, A. D. et al. Strategies to improve \u03b3\u03b4TCRs engineered T-cell therapies for the treatment of solid malignancies. Front. Immunol. 14, 1159337 (2023).","journal-title":"Front. Immunol."},{"key":"1196_CR194","doi-asserted-by":"publisher","first-page":"eabj0835","DOI":"10.1126\/scitranslmed.abj0835","volume":"13","author":"A De Gassart","year":"2021","unstructured":"De Gassart, A. et al. Development of ICT01, a first-in-class, anti-BTN3A antibody for activating V\u03b39V\u03b42 T cell-mediated antitumor immune response. Sci. Transl. Med. 13, eabj0835 (2021).","journal-title":"Sci. Transl. Med."},{"key":"1196_CR195","doi-asserted-by":"publisher","first-page":"9534","DOI":"10.1200\/JCO.2024.42.16_suppl.9534","volume":"42","author":"S Champiat","year":"2024","unstructured":"Champiat, S. et al. EVICTION study: ICT01, an anti-butyrophilin 3A monoclonal antibody activating \u03b39\u03b42 T cells in combination with pembrolizumab in checkpoint inhibitor refractory melanoma. J. Clin. Oncol. 42, 9534 (2024).","journal-title":"J. Clin. Oncol."},{"key":"1196_CR196","doi-asserted-by":"publisher","first-page":"2876","DOI":"10.1182\/blood-2024-193493","volume":"144","author":"A Maiti","year":"2024","unstructured":"Maiti, A. et al. ICT01, an investigational \u03b39\u03b42 T cell activator, added to azacitidine-venetoclax achieves frequent and early complete remissions in adults with AML unfit for intensive induction chemotherapy: interim results from the ongoing open-label, randomized phase 1 study eviction. Blood 144, 2876 (2024).","journal-title":"Blood"},{"key":"1196_CR197","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1126\/science.aay2767","volume":"369","author":"KK Payne","year":"2020","unstructured":"Payne, K. K. et al. BTN3A1 governs antitumor responses by coordinating \u03b1\u03b2 and \u03b3\u03b4 T cells. Science 369, 942\u2013949 (2020).","journal-title":"Science"},{"key":"1196_CR198","doi-asserted-by":"publisher","first-page":"7287","DOI":"10.4049\/jimmunol.0804288","volume":"182","author":"M Todaro","year":"2009","unstructured":"Todaro, M. et al. Efficient killing of human colon cancer stem cells by\u00a0\u03b3\u03b4\u00a0T lymphocytes. J. Immunol. 182, 7287\u20137196 (2009).","journal-title":"J. Immunol."},{"key":"1196_CR199","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1278099","volume":"6","author":"MR Zocchi","year":"2017","unstructured":"Zocchi, M. R. et al. Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector \u03b3\u03b4 T cells with antitumor activity. Oncoimmunology 6, e1278099 (2017).","journal-title":"Oncoimmunology"},{"key":"1196_CR200","doi-asserted-by":"publisher","first-page":"115390","DOI":"10.1016\/j.bone.2020.115390","volume":"137","author":"IR Reid","year":"2020","unstructured":"Reid, I. R. et al. Zoledronate. Bone 137, 115390 (2020).","journal-title":"Bone"},{"key":"1196_CR201","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3390\/cancers12010104","volume":"12","author":"D Di Mascolo","year":"2019","unstructured":"Di Mascolo, D. et al. Nanoformulated zoledronic acid boosts the V\u03b42 T cell immunotherapeutic potential in colorectal cancer. Cancers 12, 104 (2019).","journal-title":"Cancers"},{"key":"1196_CR202","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-005660","volume":"10","author":"R Benelli","year":"2022","unstructured":"Benelli, R. et al. Targeting of colorectal cancer organoids with zoledronic acid conjugated to the anti-EGFR antibody cetuximab. J. Immunother. Cancer 10, e005660 (2022).","journal-title":"J. Immunother. Cancer"},{"key":"1196_CR203","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.4049\/jimmunol.1700003","volume":"198","author":"CJ Tyler","year":"2017","unstructured":"Tyler, C. J. et al. Antigen-presenting human \u03b3\u03b4 T cells promote intestinal CD4+ T cell expression of IL-22 and mucosal release of calprotectin. J. Immunol. 198, 3417\u20133425 (2017).","journal-title":"J. Immunol."},{"key":"1196_CR204","doi-asserted-by":"publisher","first-page":"645131","DOI":"10.3389\/fimmu.2021.645131","volume":"12","author":"G Holmen Olofsson","year":"2021","unstructured":"Holmen Olofsson, G. et al. V\u03b39V\u03b42 T cells concurrently kill cancer cells and cross-present tumor antigens. Front. Immunol. 12, 645131 (2021).","journal-title":"Front. Immunol."},{"key":"1196_CR205","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/s41590-023-01448-7","volume":"24","author":"C Rancan","year":"2023","unstructured":"Rancan, C. et al. Exhausted intratumoral V\u03b42\u2212\u00a0\u03b3\u03b4 T cells in human kidney cancer retain effector function. Nat. Immunol. 24, 612\u2013624 (2023).","journal-title":"Nat. Immunol."},{"key":"1196_CR206","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/s43018-023-00690-0","volume":"5","author":"D Davies","year":"2024","unstructured":"Davies, D. et al. PD-1 defines a distinct, functional, tissue-adapted state in V\u03b41+ T cells with implications for cancer immunotherapy. Nat. Cancer 5, 420\u2013432 (2024).","journal-title":"Nat. Cancer"},{"key":"1196_CR207","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/s41586-022-05593-1","volume":"613","author":"NL de Vries","year":"2023","unstructured":"de Vries, N. L. et al. \u03b3\u03b4 T cells are effectors of immunotherapy in cancers with HLA class I defects. Nature 613, 743\u2013750 (2023).","journal-title":"Nature"},{"key":"1196_CR208","doi-asserted-by":"publisher","first-page":"1748991","DOI":"10.1080\/2162402X.2020.1748991","volume":"9","author":"H Lu","year":"2020","unstructured":"Lu, H. et al. B7-H3 inhibits the IFN-\u03b3-dependent cytotoxicity of V\u03b39V\u03b42 T cells against colon cancer cells. Oncoimmunology 9, 1748991 (2020).","journal-title":"Oncoimmunology"},{"key":"1196_CR209","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1016\/j.cell.2018.10.014","volume":"175","author":"P Andr\u00e9","year":"2018","unstructured":"Andr\u00e9, P. et al. Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells. Cell 175, 1731\u20131743 (2018).","journal-title":"Cell"},{"key":"1196_CR210","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/s41573-022-00520-5","volume":"21","author":"A Mantovani","year":"2022","unstructured":"Mantovani, A., Allavena, P., Marchesi, F. & Garlanda, C. Macrophages as tools and targets in cancer therapy. Nat. Rev. Drug Discov. 21, 799\u2013820 (2022).","journal-title":"Nat. Rev. Drug Discov."},{"key":"1196_CR211","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/imr.12925","volume":"298","author":"D Wesch","year":"2020","unstructured":"Wesch, D., Kabelitz, D. & Oberg, H. H. Tumor resistance mechanisms and their consequences on \u03b3\u03b4 T cell activation. Immunol. Rev. 298, 84\u201398 (2020).","journal-title":"Immunol. Rev."},{"key":"1196_CR212","doi-asserted-by":"publisher","first-page":"1440830","DOI":"10.3389\/fimmu.2024.1440830","volume":"15","author":"Q Wang","year":"2025","unstructured":"Wang, Q., Yu, M. & Zhang, S. The characteristics of the tumor immune microenvironment in colorectal cancer with different MSI status and current therapeutic strategies. Front. Immunol. 15, 1440830 (2025).","journal-title":"Front. Immunol."},{"key":"1196_CR213","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13045-024-01549-2","volume":"17","author":"KY Shen","year":"2024","unstructured":"Shen, K. Y., Zhu, Y., Xie, S. Z. & Qin, L. X. Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives. J. Hematol. Oncol. 17, 25 (2024).","journal-title":"J. Hematol. Oncol."},{"key":"1196_CR214","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/s41416-025-03045-x","volume":"133","author":"Y Jing","year":"2025","unstructured":"Jing, Y. et al. Remodelling hypoxic TNBC microenvironment restores antitumor efficacy of V\u03b39V\u03b42 T cell therapy. Br. J. Cancer 133, 365\u2013380 (2025).","journal-title":"Br. J. Cancer"},{"key":"1196_CR215","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1111\/imm.70035","volume":"177","author":"MJ Hayati","year":"2026","unstructured":"Hayati, M. J. et al. Gamma delta T cells in the tumour microenvironment: a double-edged sword. Immunology 177, 44\u201358 (2026).","journal-title":"Immunology"},{"key":"1196_CR216","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/s41590-024-01872-3","volume":"25","author":"KRB Lanng","year":"2024","unstructured":"Lanng, K. R. B., Lauridsen, E. L. & Jakobsen, M. R. The balance of STING signaling orchestrates immunity in cancer. Nat. Immunol. 25, 1144\u20131157 (2024).","journal-title":"Nat. Immunol."},{"key":"1196_CR217","doi-asserted-by":"publisher","first-page":"95","DOI":"10.15698\/cst2023.11.291","volume":"7","author":"F Richter","year":"2023","unstructured":"Richter, F., Paget, C. & Apetoh, L. STING-driven activation of T cells: relevance for the adoptive cell therapy of cancer. Cell Stress 7, 95\u2013104 (2023).","journal-title":"Cell Stress"},{"key":"1196_CR218","doi-asserted-by":"publisher","first-page":"2030021","DOI":"10.1080\/2162402X.2022.2030021","volume":"11","author":"R Serrano","year":"2022","unstructured":"Serrano, R. et al. Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma\/delta T cells. Oncoimmunology 11, 2030021 (2022).","journal-title":"Oncoimmunology"},{"key":"1196_CR219","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404432","volume":"12","author":"J Luo","year":"2025","unstructured":"Luo, J. et al. \u03b3\u03b4 T cell-mediated tumor immunity is tightly regulated by STING and TGF-\u03b2 signaling pathways. Adv. Sci. 12, e2404432 (2025).","journal-title":"Adv. Sci."},{"key":"1196_CR220","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1038\/s41590-024-01923-9","volume":"25","author":"C Scirgolea","year":"2024","unstructured":"Scirgolea, C. et al. NaCl enhances CD8+ T cell effector functions in cancer immunotherapy. Nat. Immunol. 25, 1845\u20131857 (2024).","journal-title":"Nat. Immunol."},{"key":"1196_CR221","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1038\/s41590-024-01918-6","volume":"25","author":"D Soll","year":"2024","unstructured":"Soll, D. et al. Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity. Nat. Immunol. 25, 1830\u20131844 (2024).","journal-title":"Nat. Immunol."},{"key":"1196_CR222","doi-asserted-by":"publisher","first-page":"2604908","DOI":"10.1080\/19490976.2025.2604908","volume":"18","author":"A Parthasarathy","year":"2026","unstructured":"Parthasarathy, A., Li, T. & Edelblum, K. L. Crosstalk between the microbiota and intestinal \u03b3\u03b4 T cell compartments in health and IBD. Gut Microbes 18, 2604908 (2026).","journal-title":"Gut Microbes"},{"key":"1196_CR223","doi-asserted-by":"publisher","first-page":"16812","DOI":"10.1074\/jbc.M111.327650","volume":"287","author":"Y Dai","year":"2012","unstructured":"Dai, Y., Chen, H., Mo, C., Cui, L. & He, W. Ectopically expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human \u03b3\u03b4 T cells to induce innate anti-tumor\/virus immunity. J. Biol. Chem. 287, 16812\u201316819 (2012).","journal-title":"J. Biol. Chem."},{"key":"1196_CR224","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.immuni.2013.11.001","volume":"39","author":"AM Luoma","year":"2013","unstructured":"Luoma, A. M. et al. Crystal structure of V\u03b41 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human \u03b3\u03b4 T cells. Immunity 39, 1032\u20131042 (2013).","journal-title":"Immunity"},{"key":"1196_CR225","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1038\/ni.2713","volume":"14","author":"AP Uldrich","year":"2013","unstructured":"Uldrich, A. P. et al. CD1d-lipid antigen recognition by the \u03b3\u03b4 TCR. Nat. Immunol. 14, 1137\u20131145 (2013).","journal-title":"Nat. Immunol."},{"key":"1196_CR226","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1073\/pnas.1015433108","volume":"108","author":"B Xu","year":"2011","unstructured":"Xu, B. et al. Crystal structure of a\u00a0\u03b3\u03b4\u00a0T-cell receptor specific for the human MHC class I homolog MICA. Proc. Natl Acad. Sci. USA 108, 2414\u20132419 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1196_CR227","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/s41423-025-01258-x","volume":"22","author":"H You","year":"2025","unstructured":"You, H. et al. \u03b3\u03b4 T-cell autoresponses to ectopic membrane proteins: a new type of pattern recognition. Cell. Mol. Immunol. 22, 356\u2013370 (2025).","journal-title":"Cell. Mol. Immunol."},{"key":"1196_CR228","doi-asserted-by":"publisher","first-page":"eaba9010","DOI":"10.1126\/sciimmunol.aba9010","volume":"6","author":"C Harly","year":"2021","unstructured":"Harly, C. et al. Human \u03b3\u03b4 T cell sensing of AMPK-dependent metabolic tumor reprogramming through TCR recognition of EphA2. Sci. Immunol. 6, eaba9010 (2021).","journal-title":"Sci. Immunol."},{"key":"1196_CR229","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.1073\/pnas.1621052114","volume":"114","author":"R Marlin","year":"2017","unstructured":"Marlin, R. et al. Sensing of cell stress by human \u03b3\u03b4 TCR-dependent recognition of annexin A2. Proc. Natl Acad. Sci. USA 114, 3163\u20133168 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1196_CR230","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/ni.2394","volume":"13","author":"CR Willcox","year":"2012","unstructured":"Willcox, C. R. et al. Cytomegalovirus and tumor stress surveillance by binding of a human \u03b3\u03b4 T cell antigen receptor to endothelial protein C receptor. Nat. Immunol. 13, 872\u2013879 (2012).","journal-title":"Nat. Immunol."}],"container-title":["Nature Reviews Gastroenterology & Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41575-026-01196-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41575-026-01196-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41575-026-01196-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:02:25Z","timestamp":1787659345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41575-026-01196-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":230,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["1196"],"URL":"https:\/\/doi.org\/10.1038\/s41575-026-01196-7","relation":{},"ISSN":["1759-5045","1759-5053"],"issn-type":[{"value":"1759-5045","type":"print"},{"value":"1759-5053","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"assertion":[{"value":"5 March 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}