{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:55:20Z","timestamp":1793213720604,"version":"4.5.0"},"reference-count":138,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Nephrol"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1038\/s41581-024-00857-7","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T11:04:59Z","timestamp":1718708699000},"page":"742-754","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Pulmonary hypertension and chronic kidney disease: prevalence, pathophysiology and outcomes"],"prefix":"10.1038","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8415-727X","authenticated-orcid":false,"given":"Katarina","family":"Zeder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Siew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5843-3392","authenticated-orcid":false,"given":"Evan L.","family":"Brittain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Maron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"857_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1053\/j.ajkd.2017.11.018","volume":"72","author":"M Tang","year":"2018","unstructured":"Tang, M. et al. Pulmonary hypertension, mortality, and cardiovascular disease in CKD and ESRD patients: a systematic review and meta-analysis. Am. J. Kidney Dis. 72, 75\u201383 (2018).","journal-title":"Am. J. Kidney Dis."},{"key":"857_CR2","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/1744-9987.12777","volume":"23","author":"D Bolignano","year":"2019","unstructured":"Bolignano, D., Pisano, A., Coppolino, G., Tripepi, G. L. & D\u2019Arrigo, G. Pulmonary hypertension predicts adverse outcomes in renal patients: a systematic review and meta-analysis. Ther. Apher. Dial. 23, 369\u2013384 (2019).","journal-title":"Ther. Apher. Dial."},{"key":"857_CR3","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1053\/j.ajkd.2019.08.027","volume":"75","author":"DL Edmonston","year":"2020","unstructured":"Edmonston, D. L. et al. Pulmonary hypertension subtypes and mortality in CKD. Am. J. Kidney Dis. 75, 713\u2013724 (2020).","journal-title":"Am. J. Kidney Dis."},{"key":"857_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035310","volume":"7","author":"S Pabst","year":"2012","unstructured":"Pabst, S. et al. Pulmonary hypertension in patients with chronic kidney disease on dialysis and without dialysis: results of the PEPPER-study. PLoS One 7, e35310 (2012).","journal-title":"PLoS One"},{"key":"857_CR5","doi-asserted-by":"publisher","first-page":"855","DOI":"10.2215\/CJN.10191013","volume":"9","author":"SD Navaneethan","year":"2014","unstructured":"Navaneethan, S. D. et al. Presence and outcomes of kidney disease in patients with pulmonary hypertension. Clin. J. Am. Soc. Nephrol. 9, 855\u2013863 (2014).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"857_CR6","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1177\/2045893217716108","volume":"7","author":"JM O\u2019Leary","year":"2017","unstructured":"O\u2019Leary, J. M. et al. Pulmonary hypertension in patients with chronic kidney disease: invasive hemodynamic etiology and outcomes. Pulm. Circ. 7, 674\u2013683 (2017).","journal-title":"Pulm. Circ."},{"key":"857_CR7","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13270","volume":"32","author":"JD Wolfe","year":"2018","unstructured":"Wolfe, J. D. et al. Pulmonary vascular resistance determines mortality in end-stage renal disease patients with pulmonary hypertension. Clin. Transplant. 32, e13270 (2018).","journal-title":"Clin. Transplant."},{"key":"857_CR8","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.3390\/jcm11071944","volume":"11","author":"C Brinza","year":"2022","unstructured":"Brinza, C. et al. Pulmonary arterial hypertension and adverse outcomes after kidney transplantation: a systematic review and meta-analysis. J. Clin. Med. 11, 1944 (2022).","journal-title":"J. Clin. Med."},{"key":"857_CR9","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.healun.2017.10.028","volume":"37","author":"MM Chakinala","year":"2018","unstructured":"Chakinala, M. M. et al. Impact of declining renal function on outcomes in pulmonary arterial hypertension: a REVEAL registry analysis. J. Heart Lung Transplant. 37, 696\u2013705 (2018).","journal-title":"J. Heart Lung Transplant."},{"key":"857_CR10","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1161\/CIRCULATIONAHA.107.719500","volume":"117","author":"SJ Shah","year":"2008","unstructured":"Shah, S. J. et al. Association of serum creatinine with abnormal hemodynamics and mortality in pulmonary arterial hypertension. Circulation 117, 2475\u20132483 (2008).","journal-title":"Circulation"},{"key":"857_CR11","doi-asserted-by":"publisher","first-page":"204589401882456","DOI":"10.1177\/2045894018824564","volume":"9","author":"NP Nickel","year":"2019","unstructured":"Nickel, N. P. et al. Low-grade albuminuria in pulmonary arterial hypertension. Pulm. Circ. 9, 2045894018824564 (2019).","journal-title":"Pulm. Circ."},{"key":"857_CR12","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1161\/CIRCULATIONAHA.109.898122","volume":"122","author":"RL Benza","year":"2010","unstructured":"Benza, R. L. et al. Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL). Circulation 122, 164\u2013172 (2010).","journal-title":"Circulation"},{"key":"857_CR13","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/nm1545","volume":"13","author":"JA Leopold","year":"2007","unstructured":"Leopold, J. A. et al. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat. Med. 13, 189\u2013197 (2007).","journal-title":"Nat. Med."},{"key":"857_CR14","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1056\/NEJMoa010713","volume":"345","author":"JN Cohn","year":"2001","unstructured":"Cohn, J. N. & Tognoni, G. Valsartan Heart Failure Trial Investigators. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. N. Engl. J. Med. 345, 1667\u20131675 (2001).","journal-title":"N. Engl. J. Med."},{"key":"857_CR15","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1056\/NEJMoa1812851","volume":"380","author":"EJ Velazquez","year":"2019","unstructured":"Velazquez, E. J. et al. Angiotensin-neprilysin inhibition in acute decompensated heart failure. N. Engl. J. Med. 380, 539\u2013548 (2019).","journal-title":"N. Engl. J. Med."},{"key":"857_CR16","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1161\/CIRCULATIONAHA.112.094722","volume":"126","author":"BA Maron","year":"2012","unstructured":"Maron, B. A. et al. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation 126, 963\u2013974 (2012).","journal-title":"Circulation"},{"key":"857_CR17","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1086\/675984","volume":"4","author":"BA Maron","year":"2014","unstructured":"Maron, B. A. & Leopold, J. A. The role of the renin-angiotensin-aldosterone system in the pathobiology of pulmonary arterial hypertension (2013 Grover Conference series). Pulm. Circ. 4, 200\u2013210 (2014).","journal-title":"Pulm. Circ."},{"key":"857_CR18","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/eurjhf\/hfs173","volume":"15","author":"BA Maron","year":"2013","unstructured":"Maron, B. A. et al. Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study. Eur. J. Heart Fail. 15, 277\u2013283 (2013).","journal-title":"Eur. J. Heart Fail."},{"key":"857_CR19","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.healun.2023.03.015","volume":"42","author":"J Zhang","year":"2023","unstructured":"Zhang, J. et al. Treatment effects of pulmonary artery denervation for pulmonary arterial hypertension stratified by REVEAL risk score: results from PADN-CFDA trial. J. Heart Lung Transplant. 42, 1140-1151 (2023).","journal-title":"J. Heart Lung Transplant."},{"key":"857_CR20","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1136\/heartjnl-2015-308365","volume":"102","author":"L Calvier","year":"2016","unstructured":"Calvier, L. et al. Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertension. Heart 102, 390\u2013396 (2016).","journal-title":"Heart"},{"key":"857_CR21","doi-asserted-by":"publisher","first-page":"2200879","DOI":"10.1183\/13993003.00879-2022","volume":"61","author":"M Humbert","year":"2023","unstructured":"Humbert, M. et al. 2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur. Respir. J. 61, 2200879 (2023).","journal-title":"Eur. Respir. J."},{"key":"857_CR22","doi-asserted-by":"publisher","first-page":"204589402097730","DOI":"10.1177\/2045894020977300","volume":"11","author":"L Leber","year":"2021","unstructured":"Leber, L., Beaudet, A. & Muller, A. Epidemiology of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: identification of the most accurate estimates from a systematic literature review. Pulm. Circ. 11, 2045894020977300 (2021).","journal-title":"Pulm. Circ."},{"key":"857_CR23","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1001\/jamacardio.2016.4471","volume":"1","author":"BA Maron","year":"2016","unstructured":"Maron, B. A. & Galie, N. Diagnosis, treatment, and clinical management of pulmonary arterial hypertension in the contemporary era: a review. JAMA Cardiol. 1, 1056\u20131065 (2016).","journal-title":"JAMA Cardiol."},{"key":"857_CR24","doi-asserted-by":"publisher","first-page":"825","DOI":"10.7326\/0003-4819-158-11-201306040-00007","volume":"158","author":"PE Stevens","year":"2013","unstructured":"Stevens, P. E., Levin, A. & Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members. Evaluation and management of chronic kidney disease: synopsis of the kidney disease: improving global outcomes 2012 clinical practice guideline. Ann. Intern. Med. 158, 825\u2013830 (2013).","journal-title":"Ann. Intern. Med."},{"key":"857_CR25","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1053\/j.ackd.2018.08.004","volume":"25","author":"C Ronco","year":"2018","unstructured":"Ronco, C., Bellasi, A. & Di Lullo, L. Cardiorenal syndrome: an overview. Adv. Chronic Kidney Dis. 25, 382\u2013390 (2018).","journal-title":"Adv. Chronic Kidney Dis."},{"key":"857_CR26","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.jacc.2008.07.051","volume":"52","author":"C Ronco","year":"2008","unstructured":"Ronco, C., Haapio, M., House, A. A., Anavekar, N. & Bellomo, R. Cardiorenal syndrome. J. Am. Coll. Cardiol. 52, 1527\u20131539 (2008).","journal-title":"J. Am. Coll. Cardiol."},{"key":"857_CR27","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/S2213-2600(15)00543-3","volume":"4","author":"MM Hoeper","year":"2016","unstructured":"Hoeper, M. M. et al. A global view of pulmonary hypertension. Lancet Respir. Med. 4, 306\u2013322 (2016).","journal-title":"Lancet Respir. Med."},{"key":"857_CR28","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","volume":"395","author":"GBD Chronic Kidney Disease Collaboration.","year":"2020","unstructured":"GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 395, 709\u2013733 (2020).","journal-title":"Lancet"},{"key":"857_CR29","doi-asserted-by":"publisher","first-page":"972937","DOI":"10.3389\/fmed.2022.972937","volume":"9","author":"L Wang","year":"2022","unstructured":"Wang, L. et al. Prognostic effect of pulmonary hypertension in patients with chronic kidney disease: univariate and multivariate analyses of factors associated with survival. Front. Med. 9, 972937 (2022).","journal-title":"Front. Med."},{"key":"857_CR30","doi-asserted-by":"publisher","first-page":"5695","DOI":"10.4238\/2014.July.25.25","volume":"13","author":"QM Yang","year":"2014","unstructured":"Yang, Q. M. & Bao, X. R. Pulmonary hypertension in patients with stage 1\u20133 chronic kidney disease. Genet. Mol. Res. 13, 5695\u20135703 (2014).","journal-title":"Genet. Mol. Res."},{"key":"857_CR31","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1161\/CIRCULATIONAHA.119.045409","volume":"142","author":"FH Verbrugge","year":"2020","unstructured":"Verbrugge, F. H., Guazzi, M., Testani, J. M. & Borlaug, B. A. Altered hemodynamics and end-organ damage in heart failure: impact on the lung and kidney. Circulation 142, 998\u20131012 (2020).","journal-title":"Circulation"},{"key":"857_CR32","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1159\/000487198","volume":"47","author":"L Bitker","year":"2018","unstructured":"Bitker, L. et al. Presence of kidney disease as an outcome predictor in patients with pulmonary arterial hypertension. Am. J. Nephrol. 47, 134\u2013143 (2018).","journal-title":"Am. J. Nephrol."},{"key":"857_CR33","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1086\/690018","volume":"7","author":"NP Nickel","year":"2017","unstructured":"Nickel, N. P. et al. Kidney dysfunction in patients with pulmonary arterial hypertension. Pulm. Circ. 7, 38\u201354 (2017).","journal-title":"Pulm. Circ."},{"key":"857_CR34","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/00005344-200111002-00013","volume":"38","author":"GP Rossi","year":"2001","unstructured":"Rossi, G. P., Cavallin, M., Nussdorfer, G. G. & Pessina, A. C. The endothelin-aldosterone axis and cardiovascular diseases. J. Cardiovasc. Pharmacol. 38, 49 (2001).","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"857_CR35","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.amjms.2020.01.012","volume":"359","author":"C Kopitko","year":"2020","unstructured":"Kopitko, C., Gondos, T., Fulop, T. & Medve, L. Reinterpreting renal hemodynamics: the importance of venous congestion and effective organ perfusion in acute kidney injury. Am. J. Med. Sci. 359, 193\u2013205 (2020).","journal-title":"Am. J. Med. Sci."},{"key":"857_CR36","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1093\/eurheartj\/ehx035","volume":"38","author":"W Mullens","year":"2017","unstructured":"Mullens, W., Verbrugge, F. H., Nijst, P. & Tang, W. H. W. Renal sodium avidity in heart failure: from pathophysiology to treatment strategies. Eur. Heart J. 38, 1872\u20131882 (2017).","journal-title":"Eur. Heart J."},{"key":"857_CR37","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1097\/MAJ.0b013e3181591da0","volume":"335","author":"Y Selektor","year":"2008","unstructured":"Selektor, Y. & Weber, K. T. The salt-avid state of congestive heart failure revisited. Am. J. Med. Sci. 335, 209\u2013218 (2008).","journal-title":"Am. J. Med. Sci."},{"key":"857_CR38","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/eurjhf\/hft060","volume":"15","author":"JM Testani","year":"2013","unstructured":"Testani, J. M. & Damman, K. Venous congestion and renal function in heart failure \u2026 it\u2019s complicated. Eur. J. Heart Fail. 15, 599\u2013601 (2013).","journal-title":"Eur. J. Heart Fail."},{"key":"857_CR39","first-page":"650","volume":"244","author":"JR Dilley","year":"1983","unstructured":"Dilley, J. R., Corradi, A. & Arendshorst, W. J. Glomerular ultrafiltration dynamics during increased renal venous pressure. Am. J. Physiol. 244, 650 (1983).","journal-title":"Am. J. Physiol."},{"key":"857_CR40","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s10741-011-9246-2","volume":"17","author":"B Braam","year":"2012","unstructured":"Braam, B., Cupples, W. A., Joles, J. A. & Gaillard, C. Systemic arterial and venous determinants of renal hemodynamics in congestive heart failure. Heart Fail. Rev. 17, 161\u2013175 (2012).","journal-title":"Heart Fail. Rev."},{"key":"857_CR41","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.jacc.2008.05.068","volume":"53","author":"W Mullens","year":"2009","unstructured":"Mullens, W. et al. Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J. Am. Coll. Cardiol. 53, 589\u2013596 (2009).","journal-title":"J. Am. Coll. Cardiol."},{"key":"857_CR42","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1093\/eurjhf\/hfq195","volume":"13","author":"H Uthoff","year":"2011","unstructured":"Uthoff, H. et al. Central venous pressure and impaired renal function in patients with acute heart failure. Eur. J. Heart Fail. 13, 432\u2013439 (2011).","journal-title":"Eur. J. Heart Fail."},{"key":"857_CR43","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1093\/icvts\/ivw229","volume":"23","author":"I Gambardella","year":"2016","unstructured":"Gambardella, I. et al. Congestive kidney failure in cardiac surgery: the relationship between central venous pressure and acute kidney injury. Interact. Cardiovasc. Thorac. Surg. 23, 800\u2013805 (2016).","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"857_CR44","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.jacc.2008.08.080","volume":"53","author":"K Damman","year":"2009","unstructured":"Damman, K. et al. Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. J. Am. Coll. Cardiol. 53, 582\u2013588 (2009).","journal-title":"J. Am. Coll. Cardiol."},{"key":"857_CR45","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1378\/chest.07-2331","volume":"134","author":"PE Marik","year":"2008","unstructured":"Marik, P. E., Baram, M. & Vahid, B. Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. Chest 134, 172\u2013178 (2008).","journal-title":"Chest"},{"key":"857_CR46","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1748-1716.2006.01610.x","volume":"189","author":"H Castrop","year":"2007","unstructured":"Castrop, H. Mediators of tubuloglomerular feedback regulation of glomerular filtration: ATP and adenosine. Acta Physiol. 189, 3\u201314 (2007).","journal-title":"Acta Physiol."},{"key":"857_CR47","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/ki.2009.18","volume":"75","author":"TD Bell","year":"2009","unstructured":"Bell, T. D. & Welch, W. J. Regulation of renal arteriolar tone by adenosine: novel role for type 2 receptors. Kidney Int. 75, 769\u2013771 (2009).","journal-title":"Kidney Int."},{"key":"857_CR48","doi-asserted-by":"publisher","first-page":"3908","DOI":"10.1093\/ndt\/gfr661","volume":"27","author":"R Agarwal","year":"2012","unstructured":"Agarwal, R. Prevalence, determinants and prognosis of pulmonary hypertension among hemodialysis patients. Nephrol. Dial. Transplant. 27, 3908\u20133914 (2012).","journal-title":"Nephrol. Dial. Transplant."},{"key":"857_CR49","doi-asserted-by":"publisher","first-page":"560","DOI":"10.3109\/0886022X.2013.766567","volume":"35","author":"M Abedini","year":"2013","unstructured":"Abedini, M., Sadeghi, M., Naini, A. E., Atapour, A. & Golshahi, J. Pulmonary hypertension among patients on dialysis and kidney transplant recipients. Ren. Fail. 35, 560\u2013565 (2013).","journal-title":"Ren. Fail."},{"key":"857_CR50","first-page":"279","volume":"3","author":"K Ramasubbu","year":"2010","unstructured":"Ramasubbu, K., Deswal, A., Herdejurgen, C., Aguilar, D. & Frost, A. E. A prospective echocardiographic evaluation of pulmonary hypertension in chronic hemodialysis patients in the United States: prevalence and clinical significance. Int. J. Gen. Med. 3, 279\u2013286 (2010).","journal-title":"Int. J. Gen. Med."},{"key":"857_CR51","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1097\/TP.0b013e318188d640","volume":"86","author":"N Issa","year":"2008","unstructured":"Issa, N. et al. Pulmonary hypertension is associated with reduced patient survival after kidney transplantation. Transplantation 86, 1384\u20131388 (2008).","journal-title":"Transplantation"},{"key":"857_CR52","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3389\/fmed.2018.00206","volume":"5","author":"PG de Albuquerque Suassuna","year":"2018","unstructured":"de Albuquerque Suassuna, P. G., Sanders-Pinheiro, H. & de Paula, R. B. Uremic cardiomyopathy: a new piece in the chronic kidney disease-mineral and bone disorder puzzle. Front. Med. 5, 206 (2018).","journal-title":"Front. Med."},{"key":"857_CR53","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.jacbts.2021.09.006","volume":"6","author":"Z Ma","year":"2021","unstructured":"Ma, Z. et al. \u03b2-Arrestin-mediated angiotensin II type 1 receptor activation promotes pulmonary vascular remodeling in pulmonary hypertension. JACC Basic. Transl. Sci. 6, 854\u2013869 (2021).","journal-title":"JACC Basic. Transl. Sci."},{"key":"857_CR54","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1164\/rccm.201203-0411OC","volume":"186","author":"FS de Man","year":"2012","unstructured":"de Man, F. S. et al. Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 186, 780\u2013789 (2012).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"857_CR55","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1056\/NEJMra2207410","volume":"388","author":"BA Houston","year":"2023","unstructured":"Houston, B. A., Brittain, E. L. & Tedford, R. J. Right ventricular failure. N. Engl. J. Med. 388, 1111\u20131125 (2023).","journal-title":"N. Engl. J. Med."},{"key":"857_CR56","doi-asserted-by":"publisher","first-page":"172","DOI":"10.3389\/fbioe.2019.00172","volume":"7","author":"D Wu","year":"2019","unstructured":"Wu, D. & Birukov, K. Endothelial cell mechano-metabolomic coupling to disease states in the lung microvasculature. Front. Bioeng. Biotechnol. 7, 172 (2019).","journal-title":"Front. Bioeng. Biotechnol."},{"key":"857_CR57","doi-asserted-by":"publisher","DOI":"10.1186\/cc9063","volume":"14","author":"PL Silva","year":"2010","unstructured":"Silva, P. L. et al. Hypervolemia induces and potentiates lung damage after recruitment maneuver in a model of sepsis-induced acute lung injury. Crit. Care 14, R114 (2010).","journal-title":"Crit. Care"},{"key":"857_CR58","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1378\/chest.11-1903","volume":"141","author":"AR Tonelli","year":"2012","unstructured":"Tonelli, A. R., Plana, J. C., Heresi, G. A. & Dweik, R. A. Prevalence and prognostic value of left ventricular diastolic dysfunction in idiopathic and heritable pulmonary arterial hypertension. Chest 141, 1457\u20131465 (2012).","journal-title":"Chest"},{"key":"857_CR59","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1111\/j.1542-4758.2010.00518.x","volume":"15","author":"AB Stern","year":"2011","unstructured":"Stern, A. B. & Klemmer, P. J. High-output heart failure secondary to arteriovenous fistula. Hemodial. Int. 15, 104\u2013107 (2011).","journal-title":"Hemodial. Int."},{"key":"857_CR60","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.jacc.2016.05.043","volume":"68","author":"YNV Reddy","year":"2016","unstructured":"Reddy, Y. N. V., Melenovsky, V., Redfield, M. M., Nishimura, R. A. & Borlaug, B. A. High-output heart failure: a 15-year experience. J. Am. Coll. Cardiol. 68, 473\u2013482 (2016).","journal-title":"J. Am. Coll. Cardiol."},{"key":"857_CR61","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1161\/01.CIR.32.6.1001","volume":"32","author":"E Holman","year":"1965","unstructured":"Holman, E. Abnormal arteriovenous communications. Great variability of effects with particular reference to delayed development of cardiac failure. Circulation 32, 1001\u20131009 (1965).","journal-title":"Circulation"},{"key":"857_CR62","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1172\/JCI102436","volume":"30","author":"JV Warren","year":"1951","unstructured":"Warren, J. V., Elkin, D. C. & Nickerson, J. L. The blood volume in patients with arteriovenous fistulas. J. Clin. Invest. 30, 220\u2013226 (1951).","journal-title":"J. Clin. Invest."},{"key":"857_CR63","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/sdi.12459","volume":"29","author":"NN Rao","year":"2016","unstructured":"Rao, N. N., Dundon, B. K., Worthley, M. I. & Faull, R. J. The impact of arteriovenous fistulae for hemodialysis on the cardiovascular system. Semin. Dial. 29, 214\u2013221 (2016).","journal-title":"Semin. Dial."},{"key":"857_CR64","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1053\/j.ajkd.2004.01.016","volume":"43","author":"JM MacRae","year":"2004","unstructured":"MacRae, J. M., Pandeya, S., Humen, D. P., Krivitski, N. & Lindsay, R. M. Arteriovenous fistula-associated high-output cardiac failure: a review of mechanisms. Am. J. Kidney Dis. 43, 17 (2004).","journal-title":"Am. J. Kidney Dis."},{"key":"857_CR65","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1053\/ajkd.2002.35685","volume":"40","author":"Y Ori","year":"2002","unstructured":"Ori, Y. et al. The contribution of an arteriovenous access for hemodialysis to left ventricular hypertrophy. Am. J. Kidney Dis. 40, 745\u2013752 (2002).","journal-title":"Am. J. Kidney Dis."},{"key":"857_CR66","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1177\/1129729820969314","volume":"22","author":"J Malik","year":"2021","unstructured":"Malik, J. et al. Hemodialysis vascular access affects heart function and outcomes: tips for choosing the right access for the individual patient. J. Vasc. Access. 22, 32\u201341 (2021).","journal-title":"J. Vasc. Access."},{"key":"857_CR67","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1053\/ajkd.2002.36329","volume":"40","author":"Y Iwashima","year":"2002","unstructured":"Iwashima, Y. et al. Effects of the creation of arteriovenous fistula for hemodialysis on cardiac function and natriuretic peptide levels in CRF. Am. J. Kidney Dis. 40, 974\u2013982 (2002).","journal-title":"Am. J. Kidney Dis."},{"key":"857_CR68","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1093\/eurheartj\/ehx045","volume":"38","author":"YNV Reddy","year":"2017","unstructured":"Reddy, Y. N. V. et al. Long-term cardiovascular changes following creation of arteriovenous fistula in patients with end stage renal disease. Eur. Heart J. 38, 1913\u20131923 (2017).","journal-title":"Eur. Heart J."},{"key":"857_CR69","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/00007890-200207150-00013","volume":"74","author":"P Unger","year":"2002","unstructured":"Unger, P., Wissing, K. M., de Pauw, L., Neubauer, J. & van de Borne, P. Reduction of left ventricular diameter and mass after surgical arteriovenous fistula closure in renal transplant recipients. Transplantation 74, 73\u201379 (2002).","journal-title":"Transplantation"},{"key":"857_CR70","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1093\/ndt\/16.2.368","volume":"16","author":"EC van Duijnhoven","year":"2001","unstructured":"van Duijnhoven, E. C., Cheriex, E. C., Tordoir, J. H., Kooman, J. P. & van Hooff, J. P. Effect of closure of the arteriovenous fistula on left ventricular dimensions in renal transplant patients. Nephrol. Dial. Transplant. 16, 368\u2013372 (2001).","journal-title":"Nephrol. Dial. Transplant."},{"key":"857_CR71","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1177\/1708538119866616","volume":"28","author":"F Gumus","year":"2020","unstructured":"Gumus, F. & Saricaoglu, M. C. Assessment of right heart functions in the patients with arteriovenous fistula for hemodialysis access: right ventricular free wall strain and tricuspid regurgitation jet velocity as the predictors of right heart failure. Vascular 28, 96\u2013103 (2020).","journal-title":"Vascular"},{"key":"857_CR72","doi-asserted-by":"publisher","first-page":"229","DOI":"10.5414\/CN110816","volume":"98","author":"K Manzur-Pineda","year":"2022","unstructured":"Manzur-Pineda, K. et al. Echocardiographic changes after arteriovenous fistula creation in hemodialysis patients. Clin. Nephrol. 98, 229\u2013238 (2022).","journal-title":"Clin. Nephrol."},{"key":"857_CR73","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1159\/000508957","volume":"51","author":"P Hetz","year":"2020","unstructured":"Hetz, P. et al. Prophylactic ligature of AV fistula prevents high output heart failure after kidney transplantation. Am. J. Nephrol. 51, 511\u2013519 (2020).","journal-title":"Am. J. Nephrol."},{"key":"857_CR74","doi-asserted-by":"publisher","first-page":"2819","DOI":"10.1161\/CIRCULATIONAHA.119.040361","volume":"139","author":"S Stoumpos","year":"2019","unstructured":"Stoumpos, S. & Mark, P. B. Should we ligate arteriovenous fistulas in asymptomatic patients after kidney transplantation? Circulation 139, 2819\u20132821 (2019).","journal-title":"Circulation"},{"key":"857_CR75","doi-asserted-by":"publisher","first-page":"913580","DOI":"10.3389\/fphys.2022.913580","volume":"13","author":"D Rodriguez-Espinosa","year":"2022","unstructured":"Rodriguez-Espinosa, D. et al. Multimodal strategies for the diagnosis and management of refractory congestion. an integrated cardiorenal approach. Front. Physiol. 13, 913580 (2022).","journal-title":"Front. Physiol."},{"key":"857_CR76","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41569-019-0242-x","volume":"17","author":"L Southgate","year":"2020","unstructured":"Southgate, L., Machado, R. D., Graf, S. & Morrell, N. W. Molecular genetic framework underlying pulmonary arterial hypertension. Nat. Rev. Cardiol. 17, 85\u201395 (2020).","journal-title":"Nat. Rev. Cardiol."},{"key":"857_CR77","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1056\/NEJMra2000348","volume":"385","author":"PM Hassoun","year":"2021","unstructured":"Hassoun, P. M. Pulmonary arterial hypertension. N. Engl. J. Med. 385, 2361\u20132376 (2021).","journal-title":"N. Engl. J. Med."},{"key":"857_CR78","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/joim.12131","volume":"275","author":"R Kaiser","year":"2014","unstructured":"Kaiser, R., Seiler, S., Held, M., Bals, R. & Wilkens, H. Prognostic impact of renal function in precapillary pulmonary hypertension. J. Intern. Med. 275, 116\u2013126 (2014).","journal-title":"J. Intern. Med."},{"key":"857_CR79","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.atherosclerosis.2015.01.034","volume":"239","author":"M D\u2019Apolito","year":"2015","unstructured":"D\u2019Apolito, M. et al. Urea-induced ROS cause endothelial dysfunction in chronic renal failure. Atherosclerosis 239, 393\u2013400 (2015).","journal-title":"Atherosclerosis"},{"key":"857_CR80","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1056\/NEJM199306173282402","volume":"328","author":"A Giaid","year":"1993","unstructured":"Giaid, A. et al. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 328, 1732\u20131739 (1993).","journal-title":"N. Engl. J. Med."},{"key":"857_CR81","first-page":"62","volume":"2014","author":"AH Chester","year":"2014","unstructured":"Chester, A. H. & Yacoub, M. H. The role of endothelin-1 in pulmonary arterial hypertension. Glob. Cardiol. Sci. Pract. 2014, 62\u201378 (2014).","journal-title":"Glob. Cardiol. Sci. Pract."},{"key":"857_CR82","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.phrs.2011.03.003","volume":"63","author":"D Shao","year":"2011","unstructured":"Shao, D., Park, J. E. S. & Wort, S. J. The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension. Pharmacol. Res. 63, 504\u2013511 (2011).","journal-title":"Pharmacol. Res."},{"key":"857_CR83","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.vph.2009.09.001","volume":"51","author":"S Din","year":"2009","unstructured":"Din, S., Sarathchandra, P., Yacoub, M. H. & Chester, A. H. Interaction between bone morphogenetic proteins and endothelin-1 in human pulmonary artery smooth muscle. Vasc. Pharmacol. 51, 344\u2013349 (2009).","journal-title":"Vasc. Pharmacol."},{"key":"857_CR84","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1161\/CIRCULATIONAHA.122.063327","volume":"147","author":"S Ern Yeoh","year":"2023","unstructured":"Ern Yeoh, S. et al. Endothelin-1, outcomes in patients with heart failure and reduced ejection fraction, and effects of dapagliflozin: findings from DAPA-HF. Circulation 147, 1670\u20131683 (2023).","journal-title":"Circulation"},{"key":"857_CR85","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/00005344-200000002-00005","volume":"35","author":"GP Rossi","year":"2000","unstructured":"Rossi, G. P., Belloni, A. S., Nussdorfer, G. G. & Pessina, A. C. Endothelin-1 and the adrenal gland. J. Cardiovasc. Pharmacol. 35, 17 (2000).","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"857_CR86","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1172\/JCI113876","volume":"83","author":"WL Miller","year":"1989","unstructured":"Miller, W. L., Redfield, M. M. & Burnett, J. C. J. Integrated cardiac, renal, and endocrine actions of endothelin. J. Clin. Invest. 83, 317\u2013320 (1989).","journal-title":"J. Clin. Invest."},{"key":"857_CR87","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/0024-3205(90)90126-C","volume":"46","author":"LQ Cao","year":"1990","unstructured":"Cao, L. Q. & Banks, R. O. Cardiorenal actions of endothelin, Part II: effects of cyclooxygenase inhibitors. Life Sci. 46, 585\u2013590 (1990).","journal-title":"Life Sci."},{"key":"857_CR88","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12890-018-0604-x","volume":"18","author":"M Boehm","year":"2018","unstructured":"Boehm, M. et al. Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension. BMC Pulm. Med. 18, 41\u20134 (2018).","journal-title":"BMC Pulm. Med."},{"key":"857_CR89","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1159\/000174251","volume":"20","author":"R Lariviere","year":"1997","unstructured":"Lariviere, R. et al. Increased immunoreactive endothelin-1 levels in blood vessels and glomeruli of rats with reduced renal mass. Kidney Blood Press. Res. 20, 372\u2013380 (1997).","journal-title":"Kidney Blood Press. Res."},{"key":"857_CR90","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/ki.2013.157","volume":"84","author":"RA Zager","year":"2013","unstructured":"Zager, R. A., Johnson, A. C. M., Andress, D. & Becker, K. Progressive endothelin-1 gene activation initiates chronic\/end-stage renal disease following experimental ischemic\/reperfusion injury. Kidney Int. 84, 703\u2013712 (2013).","journal-title":"Kidney Int."},{"key":"857_CR91","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12882-016-0232-8","volume":"17","author":"R Raina","year":"2016","unstructured":"Raina, R. et al. Relationship of urinary endothelin-1 with estimated glomerular filtration rate in autosomal dominant polycystic kidney disease: a pilot cross-sectional analysis. BMC Nephrol. 17, 22\u201328 (2016).","journal-title":"BMC Nephrol."},{"key":"857_CR92","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/nm.3877","volume":"21","author":"L Long","year":"2015","unstructured":"Long, L. et al. Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nat. Med. 21, 777\u2013785 (2015).","journal-title":"Nat. Med."},{"key":"857_CR93","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1055\/s-0029-1220736","volume":"41","author":"CH Yeh","year":"2009","unstructured":"Yeh, C. H., Chang, C. K., Cheng, M. F., Lin, H. J. & Cheng, J. T. Decrease of bone morphogenetic protein-7 (BMP-7) and its type II receptor (BMP-RII) in kidney of type 1-like diabetic rats. Horm. Metab. Res. 41, 605\u2013611 (2009).","journal-title":"Horm. Metab. Res."},{"key":"857_CR94","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/bph.15285","volume":"178","author":"Q Jiang","year":"2021","unstructured":"Jiang, Q. et al. Dysregulation of BMP9\/BMPR2\/SMAD signalling pathway contributes to pulmonary fibrosis and pulmonary hypertension induced by bleomycin in rats. Br. J. Pharmacol. 178, 203\u2013216 (2021).","journal-title":"Br. J. Pharmacol."},{"key":"857_CR95","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.mvr.2010.05.010","volume":"80","author":"GP Star","year":"2010","unstructured":"Star, G. P., Giovinazzo, M. & Langleben, D. Bone morphogenic protein-9 stimulates endothelin-1 release from human pulmonary microvascular endothelial cells: a potential mechanism for elevated ET-1 levels in pulmonary arterial hypertension. Microvasc. Res. 80, 349\u2013354 (2010).","journal-title":"Microvasc. Res."},{"key":"857_CR96","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030075","volume":"7","author":"JES Park","year":"2012","unstructured":"Park, J. E. S. et al. BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production. PLoS One 7, e30075 (2012).","journal-title":"PLoS One"},{"key":"857_CR97","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1161\/CIRCRESAHA.118.313356","volume":"124","author":"L Tu","year":"2019","unstructured":"Tu, L. et al. Selective BMP-9 inhibition partially protects against experimental pulmonary hypertension. Circ. Res. 124, 846\u2013855 (2019).","journal-title":"Circ. Res."},{"key":"857_CR98","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/jcmm.12373","volume":"19","author":"D Zhu","year":"2015","unstructured":"Zhu, D. et al. BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway. J. Cell. Mol. Med. 19, 165\u2013174 (2015).","journal-title":"J. Cell. Mol. Med."},{"key":"857_CR99","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/nm888","volume":"9","author":"M Zeisberg","year":"2003","unstructured":"Zeisberg, M. et al. BMP-7 counteracts TGF-\u03b21-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat. Med. 9, 964\u2013968 (2003).","journal-title":"Nat. Med."},{"key":"857_CR100","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1681\/ASN.V12112392","volume":"12","author":"S Wang","year":"2001","unstructured":"Wang, S., Lapage, J. & Hirschberg, R. Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy. J. Am. Soc. Nephrol. 12, 2392\u20132399 (2001).","journal-title":"J. Am. Soc. Nephrol."},{"key":"857_CR101","doi-asserted-by":"publisher","first-page":"909","DOI":"10.4093\/dmj.2020.0168","volume":"45","author":"L Kong","year":"2021","unstructured":"Kong, L. et al. Sulforaphane ameliorates diabetes-induced renal fibrosis through epigenetic up-regulation of BMP-7. Diabetes Metab. J. 45, 909\u2013920 (2021).","journal-title":"Diabetes Metab. J."},{"key":"857_CR102","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1152\/ajprenal.00191.2002","volume":"285","author":"M Zeisberg","year":"2003","unstructured":"Zeisberg, M. et al. Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models. Am. J. Physiol. Renal Physiol. 285, 1060 (2003).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"857_CR103","doi-asserted-by":"publisher","first-page":"4726","DOI":"10.2741\/3035","volume":"13","author":"G Mitu","year":"2008","unstructured":"Mitu, G. & Hirschberg, R. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front. Biosci. 13, 4726\u20134739 (2008).","journal-title":"Front. Biosci."},{"key":"857_CR104","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1681\/ASN.V13suppl_1s14","volume":"13","author":"J Morrissey","year":"2002","unstructured":"Morrissey, J. et al. Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. J. Am. Soc. Nephrol. 13, 14 (2002).","journal-title":"J. Am. Soc. Nephrol."},{"key":"857_CR105","doi-asserted-by":"publisher","first-page":"F644","DOI":"10.1152\/ajprenal.00550.2020","volume":"320","author":"J Schrankl","year":"2021","unstructured":"Schrankl, J. et al. Localization of angiotensin II type 1 receptor gene expression in rodent and human kidneys. Am. J. Physiol. Renal Physiol. 320, F644\u2013F653 (2021).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"857_CR106","doi-asserted-by":"publisher","first-page":"111259","DOI":"10.1016\/j.mce.2021.111259","volume":"529","author":"F Rianto","year":"2021","unstructured":"Rianto, F., Hoang, T., Revoori, R. & Sparks, M. A. Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease. Mol. Cell. Endocrinol. 529, 111259 (2021).","journal-title":"Mol. Cell. Endocrinol."},{"key":"857_CR107","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.humimm.2020.12.003","volume":"82","author":"MGH Betjes","year":"2021","unstructured":"Betjes, M. G. H., Sablik, K. A., Litjens, N. H. R., Otten, H. G. & de Weerd, A. E. ARHGDIB and AT1R autoantibodies are differentially related to the development and presence of chronic antibody-mediated rejection and fibrosis in kidney allografts. Hum. Immunol. 82, 89\u201396 (2021).","journal-title":"Hum. Immunol."},{"key":"857_CR108","doi-asserted-by":"publisher","first-page":"848915","DOI":"10.3389\/fphar.2022.848915","volume":"13","author":"Z Xu","year":"2022","unstructured":"Xu, Z. et al. Gentiopicroside ameliorates diabetic renal tubulointerstitial fibrosis via inhibiting the AT1R\/CK2\/NF-\u03baB pathway. Front. Pharmacol. 13, 848915 (2022).","journal-title":"Front. Pharmacol."},{"key":"857_CR109","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1097\/01.ASN.0000133041.27682.A2","volume":"15","author":"GA Block","year":"2004","unstructured":"Block, G. A. et al. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J. Am. Soc. Nephrol. 15, 2208\u20132218 (2004).","journal-title":"J. Am. Soc. Nephrol."},{"key":"857_CR110","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1053\/j.ajkd.2008.03.020","volume":"52","author":"F Tentori","year":"2008","unstructured":"Tentori, F. et al. Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am. J. Kidney Dis. 52, 519\u2013530 (2008).","journal-title":"Am. J. Kidney Dis."},{"key":"857_CR111","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1111\/j.1523-1755.2004.00972.x","volume":"66","author":"B Kestenbaum","year":"2004","unstructured":"Kestenbaum, B. et al. Survival following parathyroidectomy among United States dialysis patients. Kidney Int. 66, 2010\u20132016 (2004).","journal-title":"Kidney Int."},{"key":"857_CR112","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/ki.2015.72","volume":"88","author":"H Komaba","year":"2015","unstructured":"Komaba, H. et al. Parathyroidectomy and survival among Japanese hemodialysis patients with secondary hyperparathyroidism. Kidney Int. 88, 350\u2013359 (2015).","journal-title":"Kidney Int."},{"key":"857_CR113","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1093\/ndt\/gfv334","volume":"30","author":"KM Ivarsson","year":"2015","unstructured":"Ivarsson, K. M. et al. The effect of parathyroidectomy on patient survival in secondary hyperparathyroidism. Nephrol. Dial. Transplant. 30, 2027\u20132033 (2015).","journal-title":"Nephrol. Dial. Transplant."},{"key":"857_CR114","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2174\/1874306400903010053","volume":"3","author":"S Ulrich","year":"2009","unstructured":"Ulrich, S. et al. Bone mineral density and secondary hyperparathyroidism in pulmonary hypertension. Open. Respir. Med. J. 3, 53\u201360 (2009).","journal-title":"Open. Respir. Med. J."},{"key":"857_CR115","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s11255-014-0889-5","volume":"47","author":"G Genctoy","year":"2015","unstructured":"Genctoy, G., Arikan, S. & Gedik, O. Secondary hyperparathyroidism is associated with pulmonary hypertension in older patients with chronic kidney disease and proteinuria. Int. Urol. Nephrol. 47, 353\u2013358 (2015).","journal-title":"Int. Urol. Nephrol."},{"key":"857_CR116","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1378\/chest.124.6.2093","volume":"124","author":"M Amin","year":"2003","unstructured":"Amin, M., Fawzy, A., Hamid, M. A. & Elhendy, A. Pulmonary hypertension in patients with chronic renal failure: role of parathyroid hormone and pulmonary artery calcifications. Chest 124, 2093\u20132097 (2003).","journal-title":"Chest"},{"key":"857_CR117","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s11255-007-9269-8","volume":"40","author":"G Acarturk","year":"2008","unstructured":"Acarturk, G. et al. The relationship between arteriovenous fistula blood flow rate and pulmonary artery pressure in hemodialysis patients. Int. Urol. Nephrol. 40, 509\u2013513 (2008).","journal-title":"Int. Urol. Nephrol."},{"key":"857_CR118","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/ki.1995.18","volume":"47","author":"M Akmal","year":"1995","unstructured":"Akmal, M., Barndt, R. R., Ansari, A. N., Mohler, J. G. & Massry, S. G. Excess PTH in CRF induces pulmonary calcification, pulmonary hypertension and right ventricular hypertrophy. Kidney Int. 47, 158\u2013163 (1995).","journal-title":"Kidney Int."},{"key":"857_CR119","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nrneph.2012.116","volume":"8","author":"H Komaba","year":"2012","unstructured":"Komaba, H. & Fukagawa, M. The role of FGF23 in CKD \u2014 with or without Klotho. Nat. Rev. Nephrol. 8, 484\u2013490 (2012).","journal-title":"Nat. Rev. Nephrol."},{"key":"857_CR120","first-page":"300","volume":"15","author":"M Miri","year":"2021","unstructured":"Miri, M., Ahmadi, M. & Hatami, M. Correlation between fibroblast growth factor-23 and pulmonary arterial hypertension in hemodialysis patients. Iran. J. Kidney Dis. 15, 300\u2013305 (2021).","journal-title":"Iran. J. Kidney Dis."},{"key":"857_CR121","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1007\/s00392-023-02162-y","volume":"112","author":"L Widmann","year":"2023","unstructured":"Widmann, L. et al. Fibroblast growth factor 23 as a biomarker of right ventricular dysfunction in pulmonary hypertension. Clin. Res. Cardiol. 112, 1382\u20131393 (2023).","journal-title":"Clin. Res. Cardiol."},{"key":"857_CR122","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1681\/ASN.2009121311","volume":"22","author":"MC Hu","year":"2011","unstructured":"Hu, M. C. et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J. Am. Soc. Nephrol. 22, 124\u2013136 (2011).","journal-title":"J. Am. Soc. Nephrol."},{"key":"857_CR123","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1126\/science.1112766","volume":"309","author":"H Kurosu","year":"2005","unstructured":"Kurosu, H. et al. Suppression of aging in mice by the hormone Klotho. Science 309, 1829\u20131833 (2005).","journal-title":"Science"},{"key":"857_CR124","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1161\/01.HYP.0000013734.33441.EA","volume":"39","author":"H Mitani","year":"2002","unstructured":"Mitani, H. et al. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 39, 838\u2013843 (2002).","journal-title":"Hypertension"},{"key":"857_CR125","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1161\/HYPERTENSIONAHA.116.08184","volume":"68","author":"R Varshney","year":"2016","unstructured":"Varshney, R., Ali, Q., Wu, C. & Sun, Z. Monocrotaline-induced pulmonary hypertension involves downregulation of antiaging protein Klotho and eNOS activity. Hypertension 68, 1255\u20131263 (2016).","journal-title":"Hypertension"},{"key":"857_CR126","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69296-1","volume":"10","author":"S Batlahally","year":"2020","unstructured":"Batlahally, S. et al. Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants. Sci. Rep. 10, 12368 (2020).","journal-title":"Sci. Rep."},{"key":"857_CR127","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1097\/TP.0000000000003136","volume":"104","author":"SJ Chadban","year":"2020","unstructured":"Chadban, S. J. et al. KDIGO clinical practice guideline on the evaluation and management of candidates for kidney transplantation. Transplantation 104, S11\u2013S103 (2020).","journal-title":"Transplantation"},{"key":"857_CR128","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1093\/ndt\/gfu216","volume":"30","author":"D Abramowicz","year":"2015","unstructured":"Abramowicz, D. et al. European renal best practice guideline on kidney donor and recipient evaluation and perioperative care. Nephrol. Dial. Transplant. 30, 1790\u20131797 (2015).","journal-title":"Nephrol. Dial. Transplant."},{"key":"857_CR129","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1503\/cmaj.1041588","volume":"173","author":"G Knoll","year":"2005","unstructured":"Knoll, G. et al. Canadian Society of Transplantation: consensus guidelines on eligibility for kidney transplantation. CMAJ 173, 1 (2005).","journal-title":"CMAJ"},{"key":"857_CR130","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12030","volume":"12","author":"AE Frost","year":"2022","unstructured":"Frost, A. E. et al. The echocardiographic course of pretransplant pulmonary hypertension following kidney transplantation and associated outcomes. Pulm. Circ. 12, e12030 (2022).","journal-title":"Pulm. Circ."},{"key":"857_CR131","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1056\/NEJMoa2213558","volume":"388","author":"MM Hoeper","year":"2023","unstructured":"Hoeper, M. M. et al. Phase 3 trial of sotatercept for treatment of pulmonary arterial hypertension. N. Engl. J. Med. 388, 1478\u20131490 (2023).","journal-title":"N. Engl. J. Med."},{"key":"857_CR132","doi-asserted-by":"publisher","first-page":"K46","DOI":"10.1093\/eurheartj\/suz207","volume":"21","author":"S Stickel","year":"2019","unstructured":"Stickel, S., Gin-Sing, W., Wagenaar, M. & Gibbs, J. S. R. The practical management of fluid retention in adults with right heart failure due to pulmonary arterial hypertension. Eur. Heart J. Suppl. 21, K46\u2013K53 (2019).","journal-title":"Eur. Heart J. Suppl."},{"key":"857_CR133","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1111\/bcp.12616","volume":"80","author":"DJ Webb","year":"2015","unstructured":"Webb, D. J., Vachiery, J., Hwang, L. & Maurey, J. O. Sildenafil improves renal function in patients with pulmonary arterial hypertension. Br. J. Clin. Pharmacol. 80, 235\u2013241 (2015).","journal-title":"Br. J. Clin. Pharmacol."},{"key":"857_CR134","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1016\/S0140-6736(19)30772-X","volume":"393","author":"HJL Heerspink","year":"2019","unstructured":"Heerspink, H. J. L. et al. Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial. Lancet 393, 1937\u20131947 (2019).","journal-title":"Lancet"},{"key":"857_CR135","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1097\/TP.0000000000001229","volume":"100","author":"MJ Krowka","year":"2016","unstructured":"Krowka, M. J. et al. International Liver Transplant Society practice guidelines: diagnosis and management of hepatopulmonary syndrome and portopulmonary hypertension. Transplantation 100, 1440\u20131452 (2016).","journal-title":"Transplantation"},{"key":"857_CR136","doi-asserted-by":"publisher","first-page":"106","DOI":"10.31083\/j.rcm2303106","volume":"23","author":"R Nevola","year":"2022","unstructured":"Nevola, R. et al. Cardiorenal impact of SGLT-2 inhibitors: a conceptual revolution in the management of type 2 diabetes, heart failure and chronic kidney disease. Rev. Cardiovasc. Med. 23, 106 (2022).","journal-title":"Rev. Cardiovasc. Med."},{"key":"857_CR137","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1161\/CIRCULATIONAHA.120.052503","volume":"143","author":"ME Nassif","year":"2021","unstructured":"Nassif, M. E. et al. Empagliflozin effects on pulmonary artery pressure in patients with heart failure: results from the EMBRACE-HF trial. Circulation 143, 1673\u20131686 (2021).","journal-title":"Circulation"},{"key":"857_CR138","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1002\/ejhf.2032","volume":"23","author":"P Pellicori","year":"2021","unstructured":"Pellicori, P. et al. Ultrasound imaging of congestion in heart failure: examinations beyond the heart. Eur. J. Heart Fail. 23, 703\u2013712 (2021).","journal-title":"Eur. J. Heart Fail."}],"container-title":["Nature Reviews Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41581-024-00857-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41581-024-00857-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41581-024-00857-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T09:07:12Z","timestamp":1729156032000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41581-024-00857-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":138,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["857"],"URL":"https:\/\/doi.org\/10.1038\/s41581-024-00857-7","relation":{},"ISSN":["1759-5061","1759-507X"],"issn-type":[{"value":"1759-5061","type":"print"},{"value":"1759-507X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]},"assertion":[{"value":"30 May 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}