{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T03:53:51Z","timestamp":1794282831866,"version":"4.9.0"},"reference-count":183,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Nephrol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1038\/s41581-025-00960-3","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T09:09:16Z","timestamp":1745485756000},"page":"553-564","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Dialysis and cognitive impairment"],"prefix":"10.1038","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-3135","authenticated-orcid":false,"given":"Chris W.","family":"McIntyre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsh","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"960_CR1","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/s41581-022-00542-7","volume":"18","author":"AK Bello","year":"2022","unstructured":"Bello, A. K. et al. Epidemiology of haemodialysis outcomes. Nat. Rev. Nephrol. 18, 378\u2013395 (2022).","journal-title":"Nat. Rev. Nephrol."},{"key":"960_CR2","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1111\/hdi.12754","volume":"23","author":"MT Eldehni","year":"2019","unstructured":"Eldehni, M. T., Odudu, A. & Mcintyre, C. W. Brain white matter microstructure in end-stage kidney disease, cognitive impairment, and circulatory stress. Hemodial. Int. 23, 356\u2013365 (2019).","journal-title":"Hemodial. Int."},{"key":"960_CR3","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1056\/NEJMoa0904655","volume":"361","author":"M Kurella Tamura","year":"2009","unstructured":"Kurella Tamura, M. et al. Functional status of elderly adults before and after initiation of dialysis. N. Engl. J. Med. 361, 1539\u20131547 (2009).","journal-title":"N. Engl. J. Med."},{"key":"960_CR4","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1093\/ndt\/gfl275","volume":"21","author":"M Kurella","year":"2006","unstructured":"Kurella, M., Mapes, D. L., Port, F. K. & Chertow, G. M. Correlates and outcomes of dementia among dialysis patients: the Dialysis Outcomes and Practice Patterns Study. Nephrol. Dial. Transpl. 21, 2543\u20132548 (2006).","journal-title":"Nephrol. Dial. Transpl."},{"key":"960_CR5","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1177\/0891988716654987","volume":"29","author":"A Khan","year":"2016","unstructured":"Khan, A., Kalaria, R. N., Corbett, A. & Ballard, C. Update on vascular dementia. J. Geriatr. Psychiatry Neurol. 29, 281\u2013301 (2016).","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"960_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13195-014-0082-1","volume":"6","author":"J Rahimi","year":"2014","unstructured":"Rahimi, J. & Kovacs, G. G. Prevalence of mixed pathologies in the aging brain. Alzheimers Res. Ther. 6, 1\u201311 (2014).","journal-title":"Alzheimers Res. Ther."},{"key":"960_CR7","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","volume":"69","author":"JA Schneider","year":"2007","unstructured":"Schneider, J. A., Arvanitakis, Z., Bang, W. & Bennett, D. A. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69, 2197\u20132204 (2007).","journal-title":"Neurology"},{"key":"960_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-024-01313-8","volume":"29","author":"M Barber","year":"2025","unstructured":"Barber, M. Dialysis headache: an updated literature review. Curr. Pain. Headache Rep. 29, 16 (2025).","journal-title":"Curr. Pain. Headache Rep."},{"key":"960_CR9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s13760-021-01637-x","volume":"122","author":"G Viticchi","year":"2022","unstructured":"Viticchi, G. et al. Headache changes after kidney transplant. Acta Neurol. Belg. 122, 83\u201390 (2022).","journal-title":"Acta Neurol. Belg."},{"key":"960_CR10","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1017\/S1355617710001219","volume":"17","author":"S Sanchez-Roman","year":"2011","unstructured":"Sanchez-Roman, S. et al. Neurocognitive profile of an adult sample with chronic kidney disease. J. Int. Neuropsychol. Soc. 17, 80\u201390 (2011).","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"960_CR11","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/ki.2010.185","volume":"78","author":"CF Tsai","year":"2010","unstructured":"Tsai, C. F., Wang, S. J. & Fuh, J. L. Moderate chronic kidney disease is associated with reduced cognitive performance in midlife women. Kidney Int. 78, 605\u2013610 (2010).","journal-title":"Kidney Int."},{"key":"960_CR12","doi-asserted-by":"publisher","first-page":"719208","DOI":"10.3389\/fneur.2022.719208","volume":"13","author":"M Schorr","year":"2022","unstructured":"Schorr, M. et al. Cognitive impairment early after initiating maintenance hemodialysis: a cross sectional study. Front. Neurol. 13, 719208 (2022).","journal-title":"Front. Neurol."},{"key":"960_CR13","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1212\/01.wnl.0000225182.15532.40","volume":"67","author":"AM Murray","year":"2006","unstructured":"Murray, A. M. et al. Cognitive impairment in hemodialysis patients is common. Neurology 67, 216\u2013223 (2006).","journal-title":"Neurology"},{"key":"960_CR14","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1053\/j.ajkd.2015.12.028","volume":"67","author":"E O\u2019Lone","year":"2016","unstructured":"O\u2019Lone, E. et al. Cognition in people with end-stage kidney disease treated with hemodialysis: a systematic review and meta-analysis. Am. J. Kidney Dis. 67, 925\u2013935 (2016).","journal-title":"Am. J. Kidney Dis."},{"key":"960_CR15","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.kint.2016.11.015","volume":"91","author":"MK Tamura","year":"2017","unstructured":"Tamura, M. K. et al. Loss of executive function after dialysis initiation in adults with chronic kidney disease. Kidney Int. 91, 948\u2013953 (2017).","journal-title":"Kidney Int."},{"key":"960_CR16","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1159\/000068034","volume":"23","author":"T Nakatani","year":"2003","unstructured":"Nakatani, T. et al. Silent cerebral infarction in hemodialysis patients. Am. J. Nephrol. 23, 86\u201390 (2003).","journal-title":"Am. J. Nephrol."},{"key":"960_CR17","doi-asserted-by":"publisher","first-page":"S92","DOI":"10.1046\/j.1523-1755.1998.06820.x","volume":"68","author":"JM Lopez-Gomez","year":"1998","unstructured":"Lopez-Gomez, J. M., Verde, E. & Perez-Garcia, R. Blood pressure, left ventricular hypertrophy and long-term prognosis in hemodialysis patients. Kidney Int. Suppl. 68, S92\u2013S98 (1998).","journal-title":"Kidney Int. Suppl."},{"key":"960_CR18","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40885-023-00240-x","volume":"29","author":"IS Kim","year":"2023","unstructured":"Kim, I. S., Kim, S., Yoo, T. H. & Kim, J. K. Diagnosis and treatment of hypertension in dialysis patients: a systematic review. Clin. Hypertens. 29, 24 (2023).","journal-title":"Clin. Hypertens."},{"key":"960_CR19","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1046\/j.1525-1594.2003.69963.x","volume":"27","author":"T Nakatani","year":"2003","unstructured":"Nakatani, T. et al. Asymptomatic occlusive lesions of cerebral arteries in Japanese hemodialysis patients. Artif. Organs 27, 281\u2013284 (2003).","journal-title":"Artif. Organs"},{"key":"960_CR20","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.3390\/jcm13051401","volume":"13","author":"K Tsuruya","year":"2024","unstructured":"Tsuruya, K. & Yoshida, H. Cognitive impairment and brain atrophy in patients with chronic kidney disease. J. Clin. Med. 13, 1401 (2024).","journal-title":"J. Clin. Med."},{"key":"960_CR21","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1038\/sj.jcbfm.9600478","volume":"27","author":"I Prohovnik","year":"2007","unstructured":"Prohovnik, I. et al. Cerebrovascular effects of hemodialysis in chronic kidney disease. J. Cereb. Blood Flow. Metab. 27, 1861\u20131869 (2007).","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"960_CR22","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1161\/01.STR.28.3.652","volume":"28","author":"L Pantoni","year":"1997","unstructured":"Pantoni, L. & Garcia, J. H. Pathogenesis of leukoaraiosis: a review. Stroke 28, 652\u2013659 (1997).","journal-title":"Stroke"},{"key":"960_CR23","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3390\/neurolint15010016","volume":"15","author":"E Tziaka","year":"2023","unstructured":"Tziaka, E. et al. Leukoaraiosis as a predictor of depression and cognitive impairment among stroke survivors: a systematic review. Neurol. Int. 15, 238\u2013272 (2023).","journal-title":"Neurol. Int."},{"key":"960_CR24","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.57601","volume":"8","author":"E van der Plas","year":"2025","unstructured":"van der Plas, E. et al. Age-related changes in brain structure in pediatric chronic kidney disease. JAMA Netw. Open. 8, e2457601 (2025).","journal-title":"JAMA Netw. Open."},{"key":"960_CR25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1164\/rccm.201904-0816CI","volume":"202","author":"K Honarmand","year":"2020","unstructured":"Honarmand, K. et al. Natural history of cognitive impairment in critical illness survivors. a systematic review. Am. J. Respir. Crit. Care Med. 202, 193\u2013201 (2020).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"960_CR26","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1053\/j.ajkd.2007.03.019","volume":"50","author":"CD Kim","year":"2007","unstructured":"Kim, C. D. et al. High prevalence of leukoaraiosis in cerebral magnetic resonance images of patients on peritoneal dialysis. Am. J. Kidney Dis. 50, 98\u2013107 (2007).","journal-title":"Am. J. Kidney Dis."},{"key":"960_CR27","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s10157-019-01762-1","volume":"23","author":"YF Shea","year":"2019","unstructured":"Shea, Y. F., Lee, M. S. C., Mok, M. Y. M., Chan, F. H. W. & Chan, T. M. Prevalence of cognitive impairment among peritoneal dialysis patients: a systematic review and meta-analysis. Clin. Exp. Nephrol. 23, 1221\u20131234 (2019).","journal-title":"Clin. Exp. Nephrol."},{"key":"960_CR28","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1053\/j.ajkd.2019.05.017","volume":"74","author":"DA Drew","year":"2019","unstructured":"Drew, D. A., Weiner, D. E. & Sarnak, M. J. Cognitive impairment in CKD: pathophysiology, management, and prevention. Am. J. Kidney Dis. 74, 782\u2013790 (2019).","journal-title":"Am. J. Kidney Dis."},{"key":"960_CR29","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1111\/sdi.12532","volume":"29","author":"A Odudu","year":"2016","unstructured":"Odudu, A. & McIntyre, C. W. An update on intradialytic cardiac dysfunction. Semin. Dial. 29, 435\u2013441 (2016).","journal-title":"Semin. Dial."},{"key":"960_CR30","doi-asserted-by":"publisher","first-page":"549","DOI":"10.2215\/CJN.01380216","volume":"11","author":"C McIntyre","year":"2016","unstructured":"McIntyre, C. & Crowley, L. Dying to feel better: the central role of dialysis-induced tissue hypoxia. Clin. J. Am. Soc. Nephrol. 11, 549\u2013551 (2016).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"960_CR31","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.2215\/CJN.00200115","volume":"10","author":"A Odudu","year":"2015","unstructured":"Odudu, A., Eldehni, M. T., McCann, G. P. & McIntyre, C. I. W. Randomized controlled trial of individualized dialysate cooling for cardiac protection in hemodialysis patients. Clin. J. Am. Soc. Nephrol. 10, 1408\u20131417 (2015).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"960_CR32","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.2215\/CJN.04470709","volume":"4","author":"JO Burton","year":"2009","unstructured":"Burton, J. O., Jefferies, H. J., Selby, N. M. & McIntyre, C. W. Hemodialysis-induced repetitive myocardial injury results in global and segmental reduction in systolic cardiac function. Clin. J. Am. Soc. Nephrol. 4, 1925\u20131931 (2009).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"960_CR33","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2215\/CJN.03170707","volume":"3","author":"CW McIntyre","year":"2008","unstructured":"McIntyre, C. W. et al. Hemodialysis-induced cardiac dysfunction is associated with an acute reduction in global and segmental myocardial blood flow. Clin. J. Am. Soc. Nephrol. 3, 19\u201326 (2008).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"960_CR34","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1681\/ASN.2016060686","volume":"28","author":"C Buchanan","year":"2017","unstructured":"Buchanan, C. et al. Intradialytic cardiac magnetic resonance imaging to assess cardiovascular responses in a short-term trial of hemodiafiltration and hemodialysis. J. Am. Soc. Nephrol. 28, 1269\u20131277 (2017).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR35","doi-asserted-by":"publisher","first-page":"914","DOI":"10.2215\/CJN.03900808","volume":"4","author":"JO Burton","year":"2009","unstructured":"Burton, J. O., Jefferies, H. J., Selby, N. M. & McIntyre, C. W. Hemodialysis-induced cardiac injury: determinants and associated outcomes. Clin. J. Am. Soc. Nephrol. 4, 914\u2013920 (2009).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"960_CR36","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1053\/j.ajkd.2006.01.012","volume":"47","author":"NM Selby","year":"2006","unstructured":"Selby, N. M., Lambie, S. H., Camici, P. G., Baker, C. S. & McIntyre, C. W. Occurrence of regional left ventricular dysfunction in patients undergoing standard and biofeedback dialysis. Am. J. Kidney Dis. 47, 830\u2013841 (2006).","journal-title":"Am. J. Kidney Dis."},{"key":"960_CR37","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.2215\/CJN.02010606","volume":"1","author":"NM Selby","year":"2006","unstructured":"Selby, N. M., Burton, J. O., Chesterton, L. J. & McIntyre, C. W. Dialysis-induced regional left ventricular dysfunction is ameliorated by cooling the dialysate. Clin. J. Am. Soc. Nephrol. 1, 1216\u20131225 (2006).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"960_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15101-0","volume":"12","author":"BGH Janssen","year":"2022","unstructured":"Janssen, B. G. H., Zhang, Y. M., Kosik, I., Akbari, A. & McIntyre, C. W. Intravital microscopic observation of the microvasculature during hemodialysis in healthy rats. Sci. Rep. 12, 10835 (2022).","journal-title":"Sci. Rep."},{"key":"960_CR39","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1093\/ndt\/gfn501","volume":"24","author":"JJ Dasselaar","year":"2009","unstructured":"Dasselaar, J. J. et al. Haemodialysis is associated with a pronounced fall in myocardial perfusion. Nephrol. Dial. Transpl. 24, 604\u2013610 (2009).","journal-title":"Nephrol. Dial. Transpl."},{"key":"960_CR40","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000451060","volume":"45","author":"Hempel","year":"2017","unstructured":"Hempel et al. Distinct in vitro complement activation by various intravenous iron preparations. Am. J. Nephrol. 45, 49\u201359 (2017).","journal-title":"Am. J. Nephrol."},{"key":"960_CR41","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.molimm.2014.06.038","volume":"61","author":"J Szebeni","year":"2014","unstructured":"Szebeni, J. Complement activation-related pseudoallergy: a stress reaction in blood triggered by nanomedicines and biologicals. Mol. Immunol. 61, 163\u2013173 (2014).","journal-title":"Mol. Immunol."},{"key":"960_CR42","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s10047-018-1059-9","volume":"22","author":"M Kohlov\u00e1","year":"2019","unstructured":"Kohlov\u00e1, M. et al. The biocompatibility and bioactivity of hemodialysis membranes: their impact in end-stage renal disease. J. Artif. Organs 22, 14\u201328 (2019).","journal-title":"J. Artif. Organs"},{"key":"960_CR43","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1159\/000441576","volume":"40","author":"K Kokubo","year":"2015","unstructured":"Kokubo, K., Kurihara, Y., Kobayashi, K., Tsukao, H. & Kobayashi, H. Evaluation of the biocompatibility of dialysis membranes. Blood Purif. 40, 293\u2013297 (2015).","journal-title":"Blood Purif."},{"key":"960_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-0995-5","volume":"14","author":"F Poppelaars","year":"2016","unstructured":"Poppelaars, F. et al. Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients. J. Transl. Med. 14, 236 (2016).","journal-title":"J. Transl. Med."},{"key":"960_CR45","doi-asserted-by":"publisher","first-page":"25","DOI":"10.34067\/KID.0000342019","volume":"1","author":"S Wagner","year":"2020","unstructured":"Wagner, S. et al. Hemocompatibility of polysulfone hemodialyzers \u2014 exploratory studies on impact of treatment modality and dialyzer characteristics. Kidney360 1, 25\u201335 (2020).","journal-title":"Kidney360"},{"key":"960_CR46","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/aor.13887","volume":"45","author":"P Melchior","year":"2021","unstructured":"Melchior, P. et al. Complement activation by dialysis membranes and its association with secondary membrane formation and surface charge. Artif. Organs 45, 770\u2013778 (2021).","journal-title":"Artif. Organs"},{"key":"960_CR47","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.xkme.2021.04.006","volume":"3","author":"SC Skinner","year":"2021","unstructured":"Skinner, S. C. et al. Hemodialysis-related complement and contact pathway activation and cardiovascular risk: a narrative review. Kidney Med. 3, 607\u2013618 (2021).","journal-title":"Kidney Med."},{"key":"960_CR48","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/ki.2009.138","volume":"76","author":"J Mares","year":"2009","unstructured":"Mares, J., Thongboonkerd, V., Tuma, Z., Moravec, J. & Matejovic, M. Specific adsorption of some complement activation proteins to polysulfone dialysis membranes during hemodialysis. Kidney Int. 76, 404\u2013413 (2009).","journal-title":"Kidney Int."},{"key":"960_CR49","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1002\/prca.201000031","volume":"4","author":"J Mares","year":"2010","unstructured":"Mares, J. et al. Proteomic profiling of blood-dialyzer interactome reveals involvement of lectin complement pathway in hemodialysis-induced inflammatory response. Proteom. Clin. Appl. 4, 829\u2013838 (2010).","journal-title":"Proteom. Clin. Appl."},{"key":"960_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71755-8","volume":"18","author":"H Westphalen","year":"2020","unstructured":"Westphalen, H. Case studies of clinical hemodialysis membranes: influences of membrane morphology and biocompatibility on uremic blood-membrane interactions and inflammatory biomarkers. Sci. Rep. 18, 14808 (2020).","journal-title":"Sci. Rep."},{"key":"960_CR51","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/ni.1923","volume":"11","author":"D Ricklin","year":"2010","unstructured":"Ricklin, D., Hajishengallis, G., Yang, K. & Lambris, J. D. Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11, 785\u2013797 (2010).","journal-title":"Nat. Immunol."},{"key":"960_CR52","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fimmu.2018.00071","volume":"9","author":"F Poppelaars","year":"2018","unstructured":"Poppelaars, F. et al. The complement system in dialysis: a forgotten story? Front. Immunol. 9, 71 (2018).","journal-title":"Front. Immunol."},{"key":"960_CR53","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1111\/aor.13506","volume":"43","author":"J Mares","year":"2019","unstructured":"Mares, J., Tuma, Z., Moravec, J., Pavlina, R. & Matejovic, M. Proteins adsorbed to a polysulfone hemodialysis membrane under heparin and citrate anticoagulation regimens. Artif. Organs 43, 1092\u20131103 (2019).","journal-title":"Artif. Organs"},{"key":"960_CR54","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.it.2007.02.006","volume":"28","author":"MM Markiewski","year":"2007","unstructured":"Markiewski, M. M., Nilsson, B., Nilsson Ekdahl, K., Mollnes, T. E. & Lambris, J. D. Complement and coagulation: strangers or partners in crime? Trends Immunol. 28, 184\u2013192 (2007).","journal-title":"Trends Immunol."},{"key":"960_CR55","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1152\/physiol.00059.2005","volume":"21","author":"H Sun","year":"2006","unstructured":"Sun, H. The interaction between pathogens and the host coagulation system. Physiology 21, 281\u2013288 (2006).","journal-title":"Physiology"},{"key":"960_CR56","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/hdi.12052","volume":"17","author":"U Forsberg","year":"2013","unstructured":"Forsberg, U. et al. A high blood level in the venous chamber and a wet-stored dialyzer help to reduce exposure for microemboli during hemodialysis. Hemodial. Int. 17, 612\u2013617 (2013).","journal-title":"Hemodial. Int."},{"key":"960_CR57","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1093\/ndt\/gfq116","volume":"25","author":"U Forsberg","year":"2010","unstructured":"Forsberg, U., Jonsson, P., Stegmayr, C. & Stegmayr, B. Microemboli, developed during haemodialysis, pass the lung barrier and may cause ischaemic lesions in organs such as the brain. Nephrol. Dial. Transpl. 25, 2691\u20132695 (2010).","journal-title":"Nephrol. Dial. Transpl."},{"key":"960_CR58","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1111\/aor.14495","volume":"47","author":"P Jonsson","year":"2023","unstructured":"Jonsson, P., Stegmayr, C., Stegmayr, B. & Forsberg, U. Venous chambers in clinical use for hemodialysis have limited capacity to eliminate microbubbles from entering the return bloodline: an in vitro study. Artif. Organs 47, 961\u2013970 (2023).","journal-title":"Artif. Organs"},{"key":"960_CR59","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1097\/ALN.0000000000001989","volume":"128","author":"NMG Rorije","year":"2018","unstructured":"Rorije, N. M. G. et al. Microvascular permeability after an acute and chronic salt load in healthy subjects: a randomized open-label crossover intervention study. Anesthesiology 128, 352\u2013360 (2018).","journal-title":"Anesthesiology"},{"key":"960_CR60","doi-asserted-by":"publisher","first-page":"16281","DOI":"10.1073\/pnas.0707791104","volume":"104","author":"H Oberleithner","year":"2007","unstructured":"Oberleithner, H. et al. Plasma sodium stiffens vascular endothelium and reduces nitric oxide release. Proc. Natl Acad. Sci. USA 104, 16281\u201316286 (2007).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"960_CR61","first-page":"1540","volume":"32","author":"MP dell\u2019Oglio","year":"2017","unstructured":"dell\u2019Oglio, M. P. et al. Neutrophil-dependent pentraxin-3 and reactive oxygen species production modulate endothelial dysfunction in haemodialysis patients. Nephrol. Dial. Transpl. 32, 1540\u20131549 (2017).","journal-title":"Nephrol. Dial. Transpl."},{"key":"960_CR62","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1681\/ASN.2011121181","volume":"23","author":"CA Vlahu","year":"2012","unstructured":"Vlahu, C. A. et al. Damage of the endothelial glycocalyx in dialysis patients. J. Am. Soc. Nephrol. 23, 1900\u20131908 (2012).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR63","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s00424-011-0999-1","volume":"462","author":"H Oberleithner","year":"2011","unstructured":"Oberleithner, H. et al. Salt overload damages the glycocalyx sodium barrier of vascular endothelium. Pflugers Arch. 462, 519\u2013528 (2011).","journal-title":"Pflugers Arch."},{"key":"960_CR64","doi-asserted-by":"publisher","first-page":"F171","DOI":"10.1152\/ajprenal.00005.2020","volume":"319","author":"J Koch","year":"2020","unstructured":"Koch, J. et al. An acute rise of plasma Na+ concentration associates with syndecan-1 shedding during hemodialysis. Am. J. Physiol. Renal Physiol. 319, F171\u2013F177 (2020).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"960_CR65","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1097\/ACO.0000000000000957","volume":"34","author":"D De Backer","year":"2021","unstructured":"De Backer, D., Ricottilli, F. & Ospina-Tasc\u00f3n, G. A. Septic shock: a microcirculation disease. Curr. Opin. Anaesthesiol. 34, 85\u201391 (2021).","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"960_CR66","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/07853890.2019.1609076","volume":"51","author":"C Voukalis","year":"2019","unstructured":"Voukalis, C., Shantsila, E. & Lip, G. Y. H. Microparticles and cardiovascular diseases. Ann. Med. 51, 193\u2013223 (2019).","journal-title":"Ann. Med."},{"key":"960_CR67","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3747\/pdi.2014.00213","volume":"35","author":"DF Wolfgram","year":"2015","unstructured":"Wolfgram, D. F., Szabo, A., Murray, A. M. & Whittle, J. Risk of dementia in peritoneal dialysis patients compared with hemodialysis patients. Perit. Dial. Int. 35, 189\u2013198 (2015).","journal-title":"Perit. Dial. Int."},{"key":"960_CR68","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/ki.2015.62","volume":"87","author":"CW McIntyre","year":"2015","unstructured":"McIntyre, C. W. & Goldsmith, D. J. Ischemic brain injury in hemodialysis patients: which is more dangerous, hypertension or intradialytic hypotension? Kidney Int. 87, 1109\u20131115 (2015).","journal-title":"Kidney Int."},{"key":"960_CR69","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1159\/000359958","volume":"128","author":"MT Eldehni","year":"2014","unstructured":"Eldehni, M. T., Odudu, A. & McIntyre, C. W. Characterising haemodynamic stress during haemodialysis using the extrema points analysis model. Nephron Clin. Pract. 128, 39\u201344 (2014).","journal-title":"Nephron Clin. Pract."},{"key":"960_CR70","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1681\/ASN.2013101086","volume":"26","author":"MT Eldehni","year":"2015","unstructured":"Eldehni, M. T., Odudu, A. & McIntyre, C. W. Randomized clinical trial of dialysate cooling and effects on brain white matter. J. Am. Soc. Nephrol. 26, 957\u2013965 (2015).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR71","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1681\/ASN.2017101088","volume":"29","author":"HA Polinder-Bos","year":"2018","unstructured":"Polinder-Bos, H. A. et al. Hemodialysis induces an acute decline in cerebral blood flow in elderly patients. J. Am. Soc. Nephrol. 29, 1317\u20131325 (2018).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR72","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1681\/ASN.2016060704","volume":"28","author":"C MacEwen","year":"2017","unstructured":"MacEwen, C., Sutherland, S., Daly, J., Pugh, C. & Tarassenko, L. Relationship between hypotension and cerebral ischemia during hemodialysis. J. Am. Soc. Nephrol. 28, 2511\u20132520 (2017).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR73","doi-asserted-by":"publisher","first-page":"914","DOI":"10.2215\/CJN.00400119","volume":"14","author":"LM Moist","year":"2019","unstructured":"Moist, L. M. & McIntyre, C. W. Cerebral ischemia and cognitive dysfunction in patients on dialysis. Clin. J. Am. Soc. Nephrol. 14, 914\u2013916 (2019).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"960_CR74","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1681\/ASN.0000000000000105","volume":"34","author":"UC Anazodo","year":"2023","unstructured":"Anazodo, U. C. et al. Hemodialysis-related acute brain injury demonstrated by application of intradialytic magnetic resonance imaging and spectroscopy. J. Am. Soc. Nephrol. 34, 1090\u20131104 (2023).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR75","doi-asserted-by":"publisher","first-page":"616","DOI":"10.2215\/CJN.08510815","volume":"11","author":"A Meyring-W\u00f6sten","year":"2016","unstructured":"Meyring-W\u00f6sten, A. et al. Intradialytic hypoxemia and clinical outcomes in patients on hemodialysis. Clin. J. Am. Soc. Nephrol. 11, 616\u2013625 (2016).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"960_CR76","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s12028-017-0409-4","volume":"28","author":"CP Venkatasubba Rao","year":"2018","unstructured":"Venkatasubba Rao, C. P. et al. Real-time noninvasive monitoring of intracranial fluid shifts during dialysis using volumetric integral phase-shift spectroscopy (VIPS): a proof-of-concept study. Neurocrit. Care 28, 117\u2013126 (2018).","journal-title":"Neurocrit. Care"},{"key":"960_CR77","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000313","volume":"93","author":"X Kong","year":"2014","unstructured":"Kong, X. et al. Diffuse interstitial brain edema in patients with end-stage renal disease undergoing hemodialysis: a tract-based spatial statistics study. Medicine 93, e313 (2014).","journal-title":"Medicine"},{"key":"960_CR78","doi-asserted-by":"crossref","unstructured":"Vanderlinden, J., Wong, D. Y., Chiu, M., McIntyre, C. W. & Jain, A. Peritoneal dialysis patients exhibit quantifiable neurocognitive impairment but not acute ischemic brain injury: a magnetic resonance spectroscopy and diffusion tensor imaging study. SA-PO666. J. Am. Soc. Nephrol. 34(11S), p913 (2023).","DOI":"10.1681\/ASN.20233411S1913b"},{"key":"960_CR79","doi-asserted-by":"publisher","first-page":"105702","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105702","volume":"30","author":"B Choi","year":"2021","unstructured":"Choi, B., Crouzet, C., Lau, W. L., Cribbs, D. H. & Fisher, M. J. Cerebral blood flow in chronic kidney disease. J. Stroke Cerebrovasc. Dis. 30, 105702 (2021).","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"960_CR80","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1681\/ASN.2019050461","volume":"30","author":"DF Wolfgram","year":"2019","unstructured":"Wolfgram, D. F. Intradialytic cerebral hypoperfusion as mechanism for cognitive impairment in patients on hemodialysis. J. Am. Soc. Nephrol. 30, 2052\u20132058 (2019).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR81","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.neuroimage.2018.03.047","volume":"187","author":"P Liu","year":"2019","unstructured":"Liu, P., De Vis, J. B. & Lu, H. Cerebrovascular reactivity (CVR) MRI with CO2 challenge: a technical review. Neuroimage 187, 104\u2013115 (2019).","journal-title":"Neuroimage"},{"key":"960_CR82","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1016\/j.ekir.2021.04.005","volume":"6","author":"M Slessarev","year":"2021","unstructured":"Slessarev, M. et al. Hemodialysis patients have impaired cerebrovascular reactivity to CO2 compared to chronic kidney disease patients and healthy controls: a pilot study. Kidney Int. Rep. 6, 1868\u20131877 (2021).","journal-title":"Kidney Int. Rep."},{"key":"960_CR83","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3389\/fnins.2018.00409","volume":"12","author":"J Duffin","year":"2018","unstructured":"Duffin, J. et al. Cerebrovascular resistance: the basis of cerebrovascular reactivity. Front. Neurosci. 12, 409 (2018).","journal-title":"Front. Neurosci."},{"key":"960_CR84","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.nicl.2016.05.008","volume":"11","author":"K Sam","year":"2016","unstructured":"Sam, K. et al. Impaired dynamic cerebrovascular response to hypercapnia predicts development of white matter hyperintensities. Neuroimage Clin. 11, 796\u2013801 (2016).","journal-title":"Neuroimage Clin."},{"key":"960_CR85","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/sdi.12782","volume":"32","author":"CJ Grant","year":"2019","unstructured":"Grant, C. J., Huang, S. H. S. & McIntyre, C. W. Hepato-splanchnic circulatory stress: an important effect of hemodialysis. Semin. Dial. 32, 237\u2013242 (2019).","journal-title":"Semin. Dial."},{"key":"960_CR86","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1681\/ASN.2018010068","volume":"29","author":"CC Szeto","year":"2018","unstructured":"Szeto, C. C., McIntyre, C. W. & Li, P. K. T. Circulating bacterial fragments as cardiovascular risk factors in CKD. J. Am. Soc. Nephrol. 29, 1601\u20131608 (2018).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR87","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1016\/j.ekir.2021.02.008","volume":"6","author":"R Marants","year":"2021","unstructured":"Marants, R. et al. Exploring the link between hepatic perfusion and endotoxemia in hemodialysis. Kidney Int. Rep. 6, 1336\u20131345 (2021).","journal-title":"Kidney Int. Rep."},{"key":"960_CR88","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s41586-018-0023-4","volume":"556","author":"AC Wendeln","year":"2018","unstructured":"Wendeln, A. C. et al. Innate immune memory in the brain shapes neurological disease hallmarks. Nature 556, 332\u2013338 (2018).","journal-title":"Nature"},{"key":"960_CR89","doi-asserted-by":"publisher","first-page":"861714","DOI":"10.3389\/fneur.2022.861714","volume":"13","author":"T Bai","year":"2022","unstructured":"Bai, T., Yu, S. & Feng, J. Advances in the role of endothelial cells in cerebral small vessel disease. Front. Neurol. 13, 861714 (2022).","journal-title":"Front. Neurol."},{"key":"960_CR90","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nbd.2003.12.016","volume":"16","author":"P Ballabh","year":"2004","unstructured":"Ballabh, P., Braun, A. & Nedergaard, M. The blood\u2013brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol. Dis. 16, 1\u201313 (2004).","journal-title":"Neurobiol. Dis."},{"key":"960_CR91","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41591-018-0297-y","volume":"25","author":"DA Nation","year":"2019","unstructured":"Nation, D. A. et al. Blood\u2013brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat. Med. 25, 270\u2013276 (2019).","journal-title":"Nat. Med."},{"key":"960_CR92","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1681\/ASN.2019070728","volume":"31","author":"M Bobot","year":"2020","unstructured":"Bobot, M. et al. Uremic toxic blood-brain barrier disruption mediated by AhR activation leads to cognitive impairment during experimental renal dysfunction. J. Am. Soc. Nephrol. 31, 1509\u20131521 (2020).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR93","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1681\/ASN.0000000000000167","volume":"34","author":"Aditi Gupta","year":"2023","unstructured":"Gupta, Aditi Blood brain permeability in end stage kidney disease \u2014 a proof of concept study. J. Am. Soc. Nephrol. 34, 1508\u20131511 (2023).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR94","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1096\/fj.201600435RR","volume":"30","author":"MA Lopez-Ramirez","year":"2016","unstructured":"Lopez-Ramirez, M. A., Reijerkerk, A., de, Vries, H. E. & Romero, I. A. Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation. FASEB J. 30, 2662\u20132672 (2016).","journal-title":"FASEB J."},{"key":"960_CR95","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1111\/bjh.19246","volume":"204","author":"F Hannan","year":"2023","unstructured":"Hannan, F. et al. Cognitive decline in thrombotic thrombocytopenic purpura survivors: the role of white matter health as assessed by MRI. Br. J. Haematol. 204, 1005\u20131016 (2023).","journal-title":"Br. J. Haematol."},{"key":"960_CR96","doi-asserted-by":"publisher","first-page":"4211","DOI":"10.1182\/bloodadvances.2021005317","volume":"5","author":"SHS Huang","year":"2021","unstructured":"Huang, S. H. S. et al. Blood\u2013brain barrier permeability in survivors of immune-mediated thrombotic thrombocytopenic purpura: a pilot study. Blood Adv. 5, 4211\u20134218 (2021).","journal-title":"Blood Adv."},{"key":"960_CR97","doi-asserted-by":"publisher","first-page":"11881","DOI":"10.1523\/JNEUROSCI.1934-16.2016","volume":"36","author":"K Dijkstra","year":"2016","unstructured":"Dijkstra, K., Hofmeijer, J., van Gils, S. A. & van Putten, M. J. A. M. A biophysical model for cytotoxic cell swelling. J. Neurosci. 36, 11881\u201311890 (2016).","journal-title":"J. Neurosci."},{"key":"960_CR98","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.neuropharm.2018.08.004","volume":"145","author":"RM Jha","year":"2019","unstructured":"Jha, R. M., Kochanek, P. M. & Simard, J. M. Pathophysiology and treatment of cerebral edema in traumatic brain injury. Neuropharmacology 145, 230\u2013246 (2019).","journal-title":"Neuropharmacology"},{"key":"960_CR99","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s11064-014-1374-3","volume":"40","author":"JA Stokum","year":"2015","unstructured":"Stokum, J. A., Kurland, D. B., Gerzanich, V. & Simard, J. M. Mechanisms of astrocyte-mediated cerebral edema. Neurochem. Res. 40, 317\u2013328 (2015).","journal-title":"Neurochem. Res."},{"key":"960_CR100","doi-asserted-by":"publisher","first-page":"4359","DOI":"10.1172\/JCI67284","volume":"123","author":"M del Carmen Godino","year":"2013","unstructured":"del Carmen Godino, M. et al. Amelioration of ischemic brain damage by peritoneal dialysis. J. Clin. Invest. 123, 4359\u20134363 (2013).","journal-title":"J. Clin. Invest."},{"key":"960_CR101","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/B978-0-12-804279-3.00002-2","volume":"146","author":"H Tumani","year":"2017","unstructured":"Tumani, H., Huss, A. & Bachhuber, F. The cerebrospinal fluid and barriers \u2014 anatomic and physiologic considerations. Handb. Clin. Neurol. 146, 21\u201332 (2017).","journal-title":"Handb. Clin. Neurol."},{"key":"960_CR102","unstructured":"Adigun O. O. & Al-Dhahir M. A. in StatPearls https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459286\/ (StatPearls, 2024)."},{"key":"960_CR103","first-page":"390","volume":"4","author":"DJ Sexton","year":"2011","unstructured":"Sexton, D. J. et al. Haemodialysis-induced syncope due to Chiari II malformation. NDT Plus 4, 390\u2013391 (2011).","journal-title":"NDT Plus"},{"key":"960_CR104","doi-asserted-by":"publisher","first-page":"bcr2014208887","DOI":"10.1136\/bcr-2014-208887","volume":"2015","author":"P O\u2019Sullivan","year":"2015","unstructured":"O\u2019Sullivan, P., Sajjad, J., Abrar, S. & Marks, C. Headache during haemodialysis in a patient with shunt: a cause for concern? BMJ Case Rep. 2015, bcr2014208887 (2015).","journal-title":"BMJ Case Rep."},{"key":"960_CR105","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1016\/S0140-6736(11)60739-3","volume":"377","author":"C Baigent","year":"2011","unstructured":"Baigent, C. et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet 377, 2181\u20132192 (2011).","journal-title":"Lancet"},{"key":"960_CR106","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.ekir.2019.01.001","volume":"4","author":"MM Assimon","year":"2019","unstructured":"Assimon, M. M., Wang, L. & Flythe, J. E. Cumulative exposure to frequent intradialytic hypotension associates with new-onset dementia among elderly hemodialysis patients. Kidney Int. Rep. 4, 603\u2013606 (2019).","journal-title":"Kidney Int. Rep."},{"key":"960_CR107","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1111\/j.1542-4758.2009.00365.x","volume":"13","author":"PJ Owen","year":"2009","unstructured":"Owen, P. J. et al. Myocardial contractile function and intradialytic hypotension. Hemodial. Int. 13, 293\u2013300 (2009).","journal-title":"Hemodial. Int."},{"key":"960_CR108","doi-asserted-by":"publisher","first-page":"299","DOI":"10.34067\/KID.0007432021","volume":"4","author":"AA House","year":"2023","unstructured":"House, A. A. & McIntyre, C. W. Midodrine is an effective therapy for resistant intradialytic hypotension: PRO. Kidney360 4, 299\u2013301 (2023).","journal-title":"Kidney360"},{"key":"960_CR109","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1111\/j.1523-1755.2004.00812.x","volume":"66","author":"T Shoji","year":"2004","unstructured":"Shoji, T., Tsubakihara, Y., Fujii, M. & Imai, E. Hemodialysis-associated hypotension as an independent risk factor for two-year mortality in hemodialysis patients. Kidney Int. 66, 1212\u20131220 (2004).","journal-title":"Kidney Int."},{"key":"960_CR110","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1681\/ASN.0000000000000299","volume":"35","author":"CW McIntyre","year":"2024","unstructured":"McIntyre, C. W. Update on hemodialysis-induced multiorgan ischemia: brains and beyond. J. Am. Soc. Nephrol. 35, 653\u2013664 (2024).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/sdi.12317","volume":"28","author":"SHS Huang","year":"2015","unstructured":"Huang, S. H. S., Filler, G., Lindsay, R. & McIntyre, C. W. Euvolemia in hemodialysis patients: a potentially dangerous goal? Semin. Dial. 28, 1\u20135 (2015).","journal-title":"Semin. Dial."},{"key":"960_CR112","doi-asserted-by":"publisher","first-page":"c33","DOI":"10.1159\/000228073","volume":"113","author":"A Davenport","year":"2009","unstructured":"Davenport, A. Interdialytic weight gain in diabetic haemodialysis patients and diabetic control as assessed by glycated haemoglobin. Nephron Clin. Pract. 113, c33\u2013c37 (2009).","journal-title":"Nephron Clin. Pract."},{"key":"960_CR113","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1093\/ndt\/gfl236","volume":"21","author":"JM Sung","year":"2006","unstructured":"Sung, J. M. et al. The role of oral dryness in interdialytic weight gain by diabetic and non-diabetic haemodialysis patients. Nephrol. Dial. Transpl. 21, 2521\u20132528 (2006).","journal-title":"Nephrol. Dial. Transpl."},{"key":"960_CR114","first-page":"812","volume":"44","author":"G Ramdeen","year":"1998","unstructured":"Ramdeen, G., Tzamaloukas, A. H., Malhotra, D., Leger, A. & Murata, G. H. Estimates of interdialytic sodium and water intake based on the balance principle: differences between nondiabetic and diabetic subjects on hemodialysis. ASAIO 1992 44, 812\u2013817 (1998).","journal-title":"ASAIO 1992"},{"key":"960_CR115","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/S0272-6386(12)70279-2","volume":"23","author":"O Ifudu","year":"1994","unstructured":"Ifudu, O., Dulin, A. L. & Friedman, E. A. Interdialytic weight gain correlates with glycosylated hemoglobin in diabetic hemodialysis patients. Am. J. Kidney Dis. 23, 686\u2013691 (1994).","journal-title":"Am. J. Kidney Dis."},{"key":"960_CR116","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.2215\/CJN.05200610","volume":"6","author":"HJ Jefferies","year":"2011","unstructured":"Jefferies, H. J., Virk, B., Schiller, B., Moran, J. & McIntyre, C. W. Frequent hemodialysis schedules are associated with reduced levels of dialysis-induced cardiac injury (myocardial stunning). Clin. J. Am. Soc. Nephrol. 6, 1326\u20131332 (2011).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"960_CR117","doi-asserted-by":"publisher","DOI":"10.1177\/2054358120957431","volume":"7","author":"B Budhram","year":"2020","unstructured":"Budhram, B., Sinclair, A., Komenda, P., Severn, M. & Sood, M. M. A comparison of patient-reported outcome measures of quality of life by dialysis modality in the treatment of kidney failure: a systematic review. Can. J. Kidney Health Dis. 7, 2054358120957431 (2020).","journal-title":"Can. J. Kidney Health Dis."},{"key":"960_CR118","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1093\/ndt\/gfl126","volume":"21","author":"NM Selby","year":"2006","unstructured":"Selby, N. M. & McIntyre, C. W. A systematic review of the clinical effects of reducing dialysate fluid temperature. Nephrol. Dial. Transpl. 21, 1883\u20131898 (2006).","journal-title":"Nephrol. Dial. Transpl."},{"key":"960_CR119","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-04725-0","volume":"21","author":"I Dasgupta","year":"2020","unstructured":"Dasgupta, I. et al. Evaluation of the effect of Cooled HaEmodialysis on Cognitive function in patients suffering with end-stage KidnEy Disease (E-CHECKED): feasibility randomised control trial protocol. Trials 21, 820 (2020).","journal-title":"Trials"},{"key":"960_CR120","doi-asserted-by":"publisher","DOI":"10.1177\/2054358119887988","volume":"7","author":"AA Al-Jaishi","year":"2020","unstructured":"Al-Jaishi, A. A. et al. Major outcomes with personalized dialysate TEMPerature (MyTEMP): rationale and design of a pragmatic, registry-based, cluster randomized controlled trial. Can. J. Kidney Health Dis. 7, 2054358119887988 (2020).","journal-title":"Can. J. Kidney Health Dis."},{"key":"960_CR121","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1016\/S0140-6736(22)01805-0","volume":"400","author":"MyTEMP writing committee.","year":"2022","unstructured":"MyTEMP writing committee. Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial. Lancet 400, 1693\u20131703 (2022).","journal-title":"Lancet"},{"key":"960_CR122","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1093\/ndt\/gfad003","volume":"38","author":"C Zoccali","year":"2023","unstructured":"Zoccali, C. et al. Effectiveness of cold hemodialysis (HD) for the prevention of HD hypotension and mortality in the general HD population. Nephrol. Dial. Transplant. 38, 1700\u20131706 (2023).","journal-title":"Nephrol. Dial. Transplant."},{"key":"960_CR123","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.kint.2024.07.014","volume":"106","author":"M Rose","year":"2024","unstructured":"Rose, M. et al. The CONVINCE randomized trial found positive effects on quality of life for patients with chronic kidney disease treated with hemodiafiltration. Kidney Int. 106, 961\u2013971 (2024).","journal-title":"Kidney Int."},{"key":"960_CR124","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/nrneph.2013.226","volume":"9","author":"LE Crowley","year":"2013","unstructured":"Crowley, L. E. & McIntyre, C. W. Remote ischaemic conditioning-therapeutic opportunities in renal medicine. Nat. Rev. Nephrol. 9, 739\u2013746 (2013).","journal-title":"Nat. Rev. Nephrol."},{"key":"960_CR125","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1053\/j.semtcvs.2016.01.005","volume":"28","author":"O Arvola","year":"2016","unstructured":"Arvola, O. et al. Remote ischemic preconditioning reduces cerebral oxidative stress following hypothermic circulatory arrest in a porcine model. Semin. Thorac. Cardiovasc. Surg. 28, 92\u2013102 (2016).","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"key":"960_CR126","doi-asserted-by":"publisher","first-page":"BR299","DOI":"10.12659\/MSM.882038","volume":"17","author":"T Xu","year":"2011","unstructured":"Xu, T. et al. Remote ischemic preconditioning protects neurocognitive function of rats following cerebral hypoperfusion. Med. Sci. Monit. 17, BR299\u2013BR304 (2011).","journal-title":"Med. Sci. Monit."},{"key":"960_CR127","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1111\/cns.14240","volume":"29","author":"X Kan","year":"2023","unstructured":"Kan, X. et al. Efficacy and safety of remote ischemic conditioning for acute ischemic stroke: a comprehensive meta-analysis from randomized controlled trials. CNS Neurosci. Ther. 29, 2445\u20132456 (2023).","journal-title":"CNS Neurosci. Ther."},{"key":"960_CR128","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ekir.2019.08.016","volume":"5","author":"FR Salerno","year":"2020","unstructured":"Salerno, F. R., Crowley, L. E., Odudu, A. & McIntyre, C. W. Remote ischemic preconditioning protects against hemodialysis-induced cardiac injury. Kidney Int. Rep. 5, 99\u2013103 (2020).","journal-title":"Kidney Int. Rep."},{"key":"960_CR129","doi-asserted-by":"publisher","first-page":"390","DOI":"10.34067\/KID.0000000000000361","volume":"5","author":"D Verrelli","year":"2024","unstructured":"Verrelli, D. et al. Effect of intradialytic exercise on cardiovascular outcomes in maintenance hemodialysis: a systematic review and meta-analysis. Kidney360 5, 390\u2013413 (2024).","journal-title":"Kidney360"},{"key":"960_CR130","doi-asserted-by":"publisher","first-page":"560","DOI":"10.2215\/CJN.15080920","volume":"16","author":"N Hargrove","year":"2021","unstructured":"Hargrove, N. et al. Effect of aerobic exercise on dialysis-related symptoms in individuals undergoing maintenance hemodialysis: a systematic review and meta-analysis of clinical trials. Clin. J. Am. Soc. Nephrol. 16, 560\u2013574 (2021).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"960_CR131","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1093\/ndt\/gfy376","volume":"34","author":"JD Penny","year":"2019","unstructured":"Penny, J. D. et al. Intradialytic exercise preconditioning: an exploratory study on the effect on myocardial stunning. Nephrol. Dial. Transpl. 34, 1917\u20131923 (2019).","journal-title":"Nephrol. Dial. Transpl."},{"key":"960_CR132","unstructured":"US National Library of Medicine. ClinicalTrials.gov. https:\/\/clinicaltrials.gov\/study\/NCT04877041 (2025)."},{"key":"960_CR133","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1093\/ckj\/sfac021","volume":"15","author":"FR Salerno","year":"2022","unstructured":"Salerno, F. R. et al. Outcomes and predictors of skin sodium concentration in dialysis patients. Clin. Kidney J. 15, 1129\u20131136 (2022).","journal-title":"Clin. Kidney J."},{"key":"960_CR134","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1093\/ndt\/gfaa036","volume":"36","author":"E Qirjazi","year":"2021","unstructured":"Qirjazi, E. et al. Tissue sodium concentrations in chronic kidney disease and dialysis patients by lower leg sodium-23 magnetic resonance imaging. Nephrol Dial Transplant. 36, 1234\u20131243 (2021).","journal-title":"Nephrol Dial Transplant."},{"key":"960_CR135","doi-asserted-by":"publisher","first-page":"c120","DOI":"10.1159\/000094544","volume":"104","author":"A Davenport","year":"2006","unstructured":"Davenport, A. Audit of the effect of dialysate sodium concentration on inter-dialytic weight gains and blood pressure control in chronic haemodialysis patients. Nephron Clin. Pract. 104, c120\u2013c125 (2006).","journal-title":"Nephron Clin. Pract."},{"key":"960_CR136","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1681\/ASN.2018121194","volume":"30","author":"R Marants","year":"2019","unstructured":"Marants, R., Qirjazi, E., Grant, C. J., Lee, T. Y. & McIntyre, C. W. Renal perfusion during hemodialysis: intradialytic blood flow decline and effects of dialysate cooling. J. Am. Soc. Nephrol. 30, 1086\u20131095 (2019).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR137","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1053\/j.ajkd.2020.11.025","volume":"78","author":"S Lemoine","year":"2021","unstructured":"Lemoine, S., Salerno, F. R., Akbari, A. & McIntyre, C. W. Influence of dialysate sodium prescription on skin and muscle sodium concentration. Am. J. Kidney Dis. 78, 156\u2013159 (2021).","journal-title":"Am. J. Kidney Dis."},{"key":"960_CR138","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1159\/000110573","volume":"26","author":"J Titze","year":"2008","unstructured":"Titze, J. Water-free Na+ retention: interaction with hypertension and tissue hydration. Blood Purif. 26, 95\u201399 (2008).","journal-title":"Blood Purif."},{"key":"960_CR139","doi-asserted-by":"publisher","first-page":"H203","DOI":"10.1152\/ajpheart.01237.2003","volume":"287","author":"J Titze","year":"2004","unstructured":"Titze, J. et al. Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin. Am. J. Physiol. Heart Circ. Physiol. 287, H203\u2013H208 (2004).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"960_CR140","doi-asserted-by":"publisher","first-page":"S72","DOI":"10.1046\/j.1523-1755.2000.07609.x","volume":"76","author":"MJ Flanigan","year":"2000","unstructured":"Flanigan, M. J. Role of sodium in hemodialysis. Kidney Int. Suppl. 76, S72\u2013S78 (2000).","journal-title":"Kidney Int. Suppl."},{"key":"960_CR141","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1159\/000183153","volume":"36","author":"JL Funck-Brentano","year":"1984","unstructured":"Funck-Brentano, J. L. & Man, N. K. Optimization of Na content of dialysis fluid. Nephron 36, 197\u2013200 (1984).","journal-title":"Nephron"},{"key":"960_CR142","doi-asserted-by":"publisher","first-page":"E10","DOI":"10.1111\/hdi.12885","volume":"25","author":"JD Penny","year":"2021","unstructured":"Penny, J. D., Salerno, F. R., Akbari, A. & McIntyre, C. W. Pruritus: is there a grain of salty truth? Hemodial. Int. 25, E10\u2013E14 (2021).","journal-title":"Hemodial. Int."},{"key":"960_CR143","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1111\/j.1525-1594.1995.tb02278.x","volume":"19","author":"F Lopot","year":"1995","unstructured":"Lopot, F., Kotyk, P., Bl\u00e1ha, J. & V\u00e1lek, A. Influence of the dialyzer membrane material on sodium transport in hemodialysis. Artif. Organs 19, 1172\u20131175 (1995).","journal-title":"Artif. Organs"},{"key":"960_CR144","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1159\/000329355","volume":"34","author":"A Odudu","year":"2011","unstructured":"Odudu, A., Lambie, S., Taal, M. W., Fluck, R. J. & McIntyre, C. W. Use of online conductivity monitoring to study sodium mass balance in chronic haemodialysis patients: prospects for treatment individualisation. Kidney Blood Press. Res. 34, 439\u2013446 (2011).","journal-title":"Kidney Blood Press. Res."},{"key":"960_CR145","first-page":"12","volume":"10","author":"FA Gotch","year":"1980","unstructured":"Gotch, F. A., Lam, M. A., Prowitt, M. & Keen, M. Preliminary clinical results with sodium-volume modeling of hemodialysis therapy. Proc. Clin. Dial. Transpl. Forum 10, 12\u201317 (1980).","journal-title":"Proc. Clin. Dial. Transpl. Forum"},{"key":"960_CR146","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1177\/039139880703001105","volume":"30","author":"ML Keen","year":"2007","unstructured":"Keen, M. L. & Gotch, F. A. The association of the sodium \u201csetpoint\u201d to interdialytic weight gain and blood pressure in hemodialysis patients. Int. J. Artif. Organs 30, 971\u2013979 (2007).","journal-title":"Int. J. Artif. Organs"},{"key":"960_CR147","unstructured":"US National Library of Medicine. ClinicalTrials.gov. https:\/\/clinicaltrials.gov\/study\/NCT02823821 (2025)."},{"key":"960_CR148","first-page":"100591","volume":"29","author":"B Linz","year":"2020","unstructured":"Linz, B. et al. Inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut: a new antihypertensive concept. Int. J. Cardiol. Heart Vasc. 29, 100591 (2020).","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"960_CR149","doi-asserted-by":"publisher","unstructured":"Janssen B., Zhang Y., Hur, L., Akbari, A. & McIntyre C. W. Intradialytic microvascular tissue perfusion is affected by dialyzer membrane characteristics. TH-PO251. J. Am. Soc. Nephrol. 35 https:\/\/doi.org\/10.1681\/ASN.2024vc95mv1e (2024).","DOI":"10.1681\/ASN.2024vc95mv1e"},{"key":"960_CR150","first-page":"623","volume":"92","author":"JB Dossetor","year":"1965","unstructured":"Dossetor, J. B. & Zborowski, D. Mid-brain signs produced by hemodialysis and reversed by hypertonic urea. Can. Med. Assoc. J. 92, 623\u2013625 (1965).","journal-title":"Can. Med. Assoc. J."},{"key":"960_CR151","first-page":"100033","volume":"2","author":"AH Hainsworth","year":"2021","unstructured":"Hainsworth, A. H., Elahi, F. M. & Corriveau, R. A. An introduction to therapeutic approaches to vascular cognitive impairment. Cereb. Circ. Cogn. Behav. 2, 100033 (2021).","journal-title":"Cereb. Circ. Cogn. Behav."},{"key":"960_CR152","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s11886-017-0898-y","volume":"19","author":"BCM Stephan","year":"2017","unstructured":"Stephan, B. C. M. et al. Cardiovascular disease, the nitric oxide pathway and risk of cognitive impairment and dementia. Curr. Cardiol. Rep. 19, 87 (2017).","journal-title":"Curr. Cardiol. Rep."},{"key":"960_CR153","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1001\/jamaneurol.2023.1526","volume":"80","author":"JM Wardlaw","year":"2023","unstructured":"Wardlaw, J. M. et al. Isosorbide mononitrate and cilostazol treatment in patients with symptomatic cerebral small vessel disease: the lacunar intervention trial-2 (LACI-2) randomized clinical trial. JAMA Neurol. 80, 682\u2013692 (2023).","journal-title":"JAMA Neurol."},{"key":"960_CR154","doi-asserted-by":"publisher","first-page":"11067","DOI":"10.3390\/ijms231911067","volume":"23","author":"TTD Linh","year":"2022","unstructured":"Linh, T. T. D., Hsieh, Y. C., Huang, L. K. & Hu, C. J. Clinical trials of new drugs for vascular cognitive impairment and vascular dementia. Int. J. Mol. Sci. 23, 11067 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"960_CR155","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/nrd.2016.278","volume":"16","author":"P Saharinen","year":"2017","unstructured":"Saharinen, P., Eklund, L. & Alitalo, K. Therapeutic targeting of the angiopoietin\u2013TIE pathway. Nat. Rev. Drug. Discov. 16, 635\u2013661 (2017).","journal-title":"Nat. Rev. Drug. Discov."},{"key":"960_CR156","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1161\/hh1801.097034","volume":"89","author":"I Kim","year":"2001","unstructured":"Kim, I., Moon, S. O., Park, S. K., Chae, S. W. & Koh, G. Y. Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression. Circ. Res. 89, 477\u2013479 (2001).","journal-title":"Circ. Res."},{"key":"960_CR157","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1111\/cns.12307","volume":"20","author":"T Yan","year":"2014","unstructured":"Yan, T. et al. HUCBC s increase angiopoietin 1 and induce neurorestorative effects after stroke in T1 DM rats. CNS Neurosci. Ther. 20, 935\u2013944 (2014).","journal-title":"CNS Neurosci. Ther."},{"key":"960_CR158","doi-asserted-by":"publisher","first-page":"1098725","DOI":"10.3389\/fimmu.2022.1098725","volume":"13","author":"Z Zhang","year":"2022","unstructured":"Zhang, Z., Zhao, L., Zhou, X., Meng, X. & Zhou, X. Role of inflammation, immunity, and oxidative stress in hypertension: new insights and potential therapeutic targets. Front. Immunol. 13, 1098725 (2022).","journal-title":"Front. Immunol."},{"key":"960_CR159","doi-asserted-by":"publisher","first-page":"R261","DOI":"10.1186\/cc10523","volume":"15","author":"P Kumpers","year":"2011","unstructured":"Kumpers, P. et al. The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis. Crit. Care 15, R261 (2011).","journal-title":"Crit. Care"},{"key":"960_CR160","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/sj.embor.7400100","volume":"5","author":"R Tournaire","year":"2004","unstructured":"Tournaire, R. et al. A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor. EMBO Rep. 5, 262\u2013267 (2004).","journal-title":"EMBO Rep."},{"key":"960_CR161","doi-asserted-by":"publisher","first-page":"869710","DOI":"10.3389\/fncel.2022.869710","volume":"16","author":"L Culmone","year":"2022","unstructured":"Culmone, L. et al. Treatment with an angiopoietin-1 mimetic peptide improves cognitive outcome in rats with vascular dementia. Front. Cell Neurosci. 16, 869710 (2022).","journal-title":"Front. Cell Neurosci."},{"key":"960_CR162","doi-asserted-by":"publisher","first-page":"1180913","DOI":"10.3389\/fnagi.2023.1180913","volume":"15","author":"H Gao","year":"2023","unstructured":"Gao, H. et al. Early therapeutic effects of an Angiopoietin-1 mimetic peptide in middle-aged rats with vascular dementia. Front. Aging Neurosci. 15, 1180913 (2023).","journal-title":"Front. Aging Neurosci."},{"key":"960_CR163","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/cns.13541","volume":"27","author":"P Venkat","year":"2021","unstructured":"Venkat, P. et al. Treatment with an Angiopoietin-1 mimetic peptide promotes neurological recovery after stroke in diabetic rats. CNS Neurosci. Ther. 27, 48\u201359 (2021).","journal-title":"CNS Neurosci. Ther."},{"key":"960_CR164","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1177\/0963689718791568","volume":"27","author":"P Venkat","year":"2018","unstructured":"Venkat, P. et al. Angiopoietin-1 mimetic peptide promotes neuroprotection after stroke in type 1 diabetic rats. Cell Transpl. 27, 1744\u20131752 (2018).","journal-title":"Cell Transpl."},{"key":"960_CR165","doi-asserted-by":"publisher","DOI":"10.1038\/srep22111","volume":"6","author":"E R\u00fcbig","year":"2016","unstructured":"R\u00fcbig, E. et al. The synthetic Tie2 agonist peptide vasculotide protects renal vascular barrier function in experimental acute kidney injury. Sci. Rep. 6, 22111 (2016).","journal-title":"Sci. Rep."},{"key":"960_CR166","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014390","volume":"98","author":"X Tian","year":"2019","unstructured":"Tian, X. et al. The comparison of cognitive function and risk of dementia in CKD patients under peritoneal dialysis and hemodialysis: a PRISMA-compliant systematic review and meta-analysis. Medicine 98, e14390 (2019).","journal-title":"Medicine"},{"key":"960_CR167","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s11255-020-02603-x","volume":"53","author":"H Ali","year":"2021","unstructured":"Ali, H. et al. The effects of dialysis modality choice on cognitive functions in patients with end-stage renal failure: a systematic review and meta-analysis. Int. Urol. Nephrol. 53, 155\u2013163 (2021).","journal-title":"Int. Urol. Nephrol."},{"key":"960_CR168","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3747\/pdi.2010.00007","volume":"31","author":"NM Selby","year":"2011","unstructured":"Selby, N. M. & McIntyre, C. W. Peritoneal dialysis is not associated with myocardial stunning. Perit. Dial. Int. 31, 27\u201333 (2011).","journal-title":"Perit. Dial. Int."},{"key":"960_CR169","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1177\/0896860820953712","volume":"41","author":"S Ghoshal","year":"2021","unstructured":"Ghoshal, S., O\u2019Connell, N., Tegeler, C. & Freedman, B. I. Cerebral hemodynamics in peritoneal dialysis versus intermittent hemodialysis: a transcranial Doppler pilot study. Perit. Dial. Int. 41, 417\u2013422 (2021).","journal-title":"Perit. Dial. Int."},{"key":"960_CR170","first-page":"CD013800","volume":"6","author":"I Ethier","year":"2024","unstructured":"Ethier, I. et al. Peritoneal dialysis versus haemodialysis for people commencing dialysis. Cochrane Database Syst. Rev. 6, CD013800 (2024).","journal-title":"Cochrane Database Syst. Rev."},{"key":"960_CR171","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1053\/j.ajkd.2010.03.020","volume":"56","author":"T Shafi","year":"2010","unstructured":"Shafi, T. et al. Association of residual urine output with mortality, quality of life, and inflammation in incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for End-Stage Renal Disease (CHOICE) Study. Am. J. Kidney Dis. 56, 348\u2013358 (2010).","journal-title":"Am. J. Kidney Dis."},{"key":"960_CR172","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1053\/j.ajkd.2012.09.009","volume":"61","author":"M Kurella Tamura","year":"2013","unstructured":"Kurella Tamura, M. et al. Effect of more frequent hemodialysis on cognitive function in the frequent hemodialysis network trials. Am. J. Kidney Dis. 61, 228\u2013237 (2013).","journal-title":"Am. J. Kidney Dis."},{"key":"960_CR173","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57004-7","volume":"9","author":"YT Lin","year":"2019","unstructured":"Lin, Y. T. et al. Protein-bound uremic toxins are associated with cognitive function among patients undergoing maintenance hemodialysis. Sci. Rep. 9, 20388 (2019).","journal-title":"Sci. Rep."},{"key":"960_CR174","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nrneph.2010.68","volume":"6","author":"RT Krediet","year":"2010","unstructured":"Krediet, R. T. & Balafa, O. Cardiovascular risk in the peritoneal dialysis patient. Nat. Rev. Nephrol. 6, 451\u2013460 (2010).","journal-title":"Nat. Rev. Nephrol."},{"key":"960_CR175","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s40472-020-00284-0","volume":"7","author":"A Jurgensen","year":"2020","unstructured":"Jurgensen, A., Qannus, A. A. & Gupta, A. Cognitive function in kidney transplantation. Curr. Transpl. Rep. 7, 145\u2013153 (2020).","journal-title":"Curr. Transpl. Rep."},{"key":"960_CR176","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1046\/j.1523-1755.2003.00209.x","volume":"64","author":"J Marshall","year":"2003","unstructured":"Marshall, J., Jennings, P., Scott, A., Fluck, R. J. & McIntyre, C. W. Glycemic control in diabetic CAPD patients assessed by continuous glucose monitoring system (CGMS). Kidney Int. 64, 1480\u20131486 (2003).","journal-title":"Kidney Int."},{"key":"960_CR177","doi-asserted-by":"publisher","first-page":"51","DOI":"10.2215\/CJN.05350709","volume":"5","author":"NJ McIntyre","year":"2010","unstructured":"McIntyre, N. J. et al. Tissue-advanced glycation end product concentration in dialysis patients. Clin. J. Am. Soc. Nephrol. 5, 51\u201355 (2010).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"960_CR178","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1007\/s11255-013-0597-6","volume":"46","author":"F Mac-Way","year":"2014","unstructured":"Mac-Way, F. et al. Advanced glycation end products, aortic stiffness, and wave reflection in peritoneal dialysis as compared to hemodialysis. Int. Urol. Nephrol. 46, 817\u2013824 (2014).","journal-title":"Int. Urol. Nephrol."},{"key":"960_CR179","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jns.2012.02.018","volume":"317","author":"J Li","year":"2012","unstructured":"Li, J., Liu, D., Sun, L., Lu, Y. & Zhang, Z. Advanced glycation end products and neurodegenerative diseases: mechanisms and perspective. J. Neurol. Sci. 317, 1\u20135 (2012).","journal-title":"J. Neurol. Sci."},{"key":"960_CR180","doi-asserted-by":"publisher","first-page":"741","DOI":"10.3233\/JAD-190878","volume":"74","author":"Y Tabara","year":"2020","unstructured":"Tabara, Y. et al. Advanced glycation end product accumulation is associated with lower cognitive performance in an older general population: the Nagahama study. J. Alzheimers Dis. 74, 741\u2013746 (2020).","journal-title":"J. Alzheimers Dis."},{"key":"960_CR181","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1681\/ASN.2012100987","volume":"24","author":"PKT Li","year":"2013","unstructured":"Li, P. K. T. et al. Randomized, controlled trial of glucose-sparing peritoneal dialysis in diabetic patients. J. Am. Soc. Nephrol. 24, 1889\u20131900 (2013).","journal-title":"J. Am. Soc. Nephrol."},{"key":"960_CR182","doi-asserted-by":"publisher","first-page":"3494867","DOI":"10.1155\/2017\/3494867","volume":"2017","author":"V Liakopoulos","year":"2017","unstructured":"Liakopoulos V., Roumeliotis S., Gorny X., Eleftheriadis T., Mertens P. R. Oxidative stress in patients undergoing peritoneal dialysis: a current review of the literature. Oxid. Med. Cell Longev. 2017, 3494867 (2017).","journal-title":"Oxid. Med. Cell Longev."},{"key":"960_CR183","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.2215\/CJN.05410514","volume":"10","author":"S Yohanna","year":"2015","unstructured":"Yohanna, S. et al. Effect of neutral-pH, low-glucose degradation product peritoneal dialysis solutions on residual renal function, urine volume, and ultrafiltration: a systematic review and meta-analysis. Clin. J. Am. Soc. Nephrol. 10, 1380\u20131388 (2015).","journal-title":"Clin. J. Am. Soc. Nephrol."}],"container-title":["Nature Reviews Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41581-025-00960-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41581-025-00960-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41581-025-00960-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T15:32:07Z","timestamp":1757172727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41581-025-00960-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":183,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["960"],"URL":"https:\/\/doi.org\/10.1038\/s41581-025-00960-3","relation":{},"ISSN":["1759-5061","1759-507X"],"issn-type":[{"value":"1759-5061","type":"print"},{"value":"1759-507X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,24]]},"assertion":[{"value":"25 March 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}