{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:41:57Z","timestamp":1793835717038,"version":"4.6.1"},"reference-count":212,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Nephrol"],"DOI":"10.1038\/s41581-026-01131-8","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:01:24Z","timestamp":1789747284000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ferroptosis in kidney disease"],"prefix":"10.1038","author":[{"given":"Tianyi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6498-9685","authenticated-orcid":false,"given":"Shumin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-9725","authenticated-orcid":false,"given":"Andreas","family":"Linkermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8099-6327","authenticated-orcid":false,"given":"Junxia","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-0003","authenticated-orcid":false,"given":"Fudi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"1131_CR1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41581-023-00694-0","volume":"19","author":"AB Sanz","year":"2023","unstructured":"Sanz, A. B., Sanchez-Nino, M. D., Ramos, A. M. & Ortiz, A. Regulated cell death pathways in kidney disease. Nat. Rev. Nephrol. 19, 281\u2013299 (2023).","journal-title":"Nat. Rev. Nephrol."},{"key":"1131_CR2","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon, S. J. et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060\u20131072 (2012).","journal-title":"Cell"},{"key":"1131_CR3","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","volume":"8","author":"S Sun","year":"2023","unstructured":"Sun, S., Shen, J., Jiang, J., Wang, F. & Min, J. Targeting ferroptosis opens new avenues for the development of novel therapeutics. Signal. Transduct. Target. Ther. 8, 372 (2023).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"1131_CR4","doi-asserted-by":"publisher","first-page":"16836","DOI":"10.1073\/pnas.1415518111","volume":"111","author":"A Linkermann","year":"2014","unstructured":"Linkermann, A. et al. Synchronized renal tubular cell death involves ferroptosis. Proc. Natl Acad. Sci. USA 111, 16836\u201316841 (2014).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1131_CR5","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JP Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli, J. P. et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat. Cell Biol. 16, 1180\u20131191 (2014).","journal-title":"Nat. Cell Biol."},{"key":"1131_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202416441","volume":"12","author":"J Chen","year":"2025","unstructured":"Chen, J. et al. CNPY2 aggravates renal tubular cell ferroptosis in diabetic nephropathy by regulating PERK\/ATF4\/CHAC1 pathway and MAM integrity. Adv. Sci. 12, 2416441 (2025).","journal-title":"Adv. Sci."},{"key":"1131_CR7","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1681\/ASN.2018010039","volume":"30","author":"R Schreiber","year":"2019","unstructured":"Schreiber, R. et al. Lipid peroxidation drives renal cyst growth in vitro through activation of TMEM16A. J. Am. Soc. Nephrol. 30, 228\u2013242 (2019).","journal-title":"J. Am. Soc. Nephrol."},{"key":"1131_CR8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41581-022-00631-7","volume":"19","author":"C Tang","year":"2022","unstructured":"Tang, C., Livingston, M. J., Safirstein, R. & Dong, Z. Cisplatin nephrotoxicity: new insights and therapeutic implications. Nat. Rev. Nephrol. 19, 53\u201372 (2022).","journal-title":"Nat. Rev. Nephrol."},{"key":"1131_CR9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","volume":"9","author":"Q Zhou","year":"2024","unstructured":"Zhou, Q. et al. Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies. Signal. Transduct. Target. Ther. 9, 55 (2024).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"1131_CR10","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/s41581-023-00689-x","volume":"19","author":"H Bay\u0131r","year":"2023","unstructured":"Bay\u0131r, H., Dixon, S. J., Tyurina, Y. Y., Kellum, J. A. & Kagan, V. E. Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney. Nat. Rev. Nephrol. 19, 315\u2013336 (2023).","journal-title":"Nat. Rev. Nephrol."},{"key":"1131_CR11","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/hep.29117","volume":"66","author":"H Wang","year":"2017","unstructured":"Wang, H. et al. Characterization of ferroptosis in murine models of hemochromatosis. Hepatology 66, 449\u2013465 (2017).","journal-title":"Hepatology"},{"key":"1131_CR12","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","volume":"142","author":"MW Hentze","year":"2010","unstructured":"Hentze, M. W., Muckenthaler, M. U., Galy, B. & Camaschella, C. Two to tango: regulation of mammalian iron metabolism. Cell 142, 24\u201338 (2010).","journal-title":"Cell"},{"key":"1131_CR13","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/nrd.2016.248","volume":"16","author":"BJ Crielaard","year":"2017","unstructured":"Crielaard, B. J., Lammers, T. & Rivella, S. Targeting iron metabolism in drug discovery and delivery. Nat. Rev. Drug Discov. 16, 400\u2013423 (2017).","journal-title":"Nat. Rev. Drug Discov."},{"key":"1131_CR14","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2016.12.034","volume":"168","author":"MU Muckenthaler","year":"2017","unstructured":"Muckenthaler, M. U., Rivella, S., Hentze, M. W. & Galy, B. A red carpet for iron metabolism. Cell 168, 344\u2013361 (2017).","journal-title":"Cell"},{"key":"1131_CR15","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.cmet.2015.09.006","volume":"22","author":"H Drakesmith","year":"2015","unstructured":"Drakesmith, H., Nemeth, E. & Ganz, T. Ironing out ferroportin. Cell Metab. 22, 777\u2013787 (2015).","journal-title":"Cell Metab."},{"key":"1131_CR16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","volume":"20","author":"X Fang","year":"2022","unstructured":"Fang, X., Ardehali, H., Min, J. & Wang, F. The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease. Nat. Rev. Cardiol. 20, 7\u201323 (2022).","journal-title":"Nat. Rev. Cardiol."},{"key":"1131_CR17","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1681\/ASN.2006080908","volume":"18","author":"D Zhang","year":"2007","unstructured":"Zhang, D., Meyron-Holtz, E. & Rouault, T. A. Renal iron metabolism. J. Am. Soc. Nephrol. 18, 401\u2013406 (2007).","journal-title":"J. Am. Soc. Nephrol."},{"key":"1131_CR18","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1146\/annurev-med-043021-032816","volume":"74","author":"E Nemeth","year":"2023","unstructured":"Nemeth, E. & Ganz, T. Hepcidin and iron in health and disease. Annu. Rev. Med. 74, 261\u2013277 (2023).","journal-title":"Annu. Rev. Med."},{"key":"1131_CR19","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1182\/blood.2020008986","volume":"138","author":"L Jiang","year":"2021","unstructured":"Jiang, L. et al. RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation. Blood 138, 689\u2013705 (2021).","journal-title":"Blood"},{"key":"1131_CR20","doi-asserted-by":"publisher","first-page":"3730","DOI":"10.1182\/blood-2006-06-028787","volume":"108","author":"M Pak","year":"2006","unstructured":"Pak, M., Lopez, M. A., Gabayan, V., Ganz, T. & Rivera, S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 108, 3730\u20133735 (2006).","journal-title":"Blood"},{"key":"1131_CR21","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1182\/blood.2019002907","volume":"136","author":"Y Yu","year":"2020","unstructured":"Yu, Y. et al. Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis. Blood 136, 726\u2013739 (2020).","journal-title":"Blood"},{"key":"1131_CR22","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","volume":"59","author":"M Gao","year":"2015","unstructured":"Gao, M., Monian, P., Quadri, N., Ramasamy, R. & Jiang, X. Glutaminolysis and transferrin regulate ferroptosis. Mol. Cell 59, 298\u2013308 (2015).","journal-title":"Mol. Cell"},{"key":"1131_CR23","doi-asserted-by":"publisher","first-page":"3411","DOI":"10.1016\/j.celrep.2020.02.049","volume":"30","author":"H Feng","year":"2020","unstructured":"Feng, H. et al. Transferrin receptor is a specific ferroptosis marker. Cell Rep. 30, 3411\u20133423e3417 (2020).","journal-title":"Cell Rep."},{"key":"1131_CR24","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1161\/CIRCRESAHA.120.316509","volume":"127","author":"X Fang","year":"2020","unstructured":"Fang, X. et al. Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis. Circ. Res. 127, 486\u2013501 (2020).","journal-title":"Circ. Res."},{"key":"1131_CR25","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature13148","volume":"509","author":"JD Mancias","year":"2014","unstructured":"Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W. & Kimmelman, A. C. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature 509, 105\u2013109 (2014).","journal-title":"Nature"},{"key":"1131_CR26","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","volume":"12","author":"W Hou","year":"2016","unstructured":"Hou, W. et al. Autophagy promotes ferroptosis by degradation of ferritin. Autophagy 12, 1425\u20131428 (2016).","journal-title":"Autophagy"},{"key":"1131_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28718-6","volume":"13","author":"S Van Coillie","year":"2022","unstructured":"Van Coillie, S. et al. Targeting ferroptosis protects against experimental (multi)organ dysfunction and death. Nat. Commun. 13, 1046 (2022).","journal-title":"Nat. Commun."},{"key":"1131_CR28","doi-asserted-by":"publisher","first-page":"F178","DOI":"10.1152\/ajprenal.00184.2023","volume":"326","author":"A Soofi","year":"2024","unstructured":"Soofi, A. et al. Renal-specific loss of ferroportin disrupts iron homeostasis and attenuates recovery from acute kidney injury. Am. J. Physiol. Ren. Physiol. 326, F178\u2013F188 (2024).","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"1131_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25377-x","volume":"12","author":"Y Guan","year":"2021","unstructured":"Guan, Y. et al. A single genetic locus controls both expression of DPEP1\/CHMP1A and kidney disease development via ferroptosis. Nat. Commun. 12, 5078 (2021).","journal-title":"Nat. Commun."},{"key":"1131_CR30","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell, B. R. et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 171, 273\u2013285 (2017).","journal-title":"Cell"},{"key":"1131_CR31","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","volume":"82","author":"D Liang","year":"2022","unstructured":"Liang, D., Minikes, A. M. & Jiang, X. Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol. Cell 82, 2215\u20132227 (2022).","journal-title":"Mol. Cell"},{"key":"1131_CR32","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3945\/an.113.004648","volume":"4","author":"DG Mashek","year":"2013","unstructured":"Mashek, D. G. Hepatic fatty acid trafficking: multiple forks in the road. Adv. Nutr. 4, 697\u2013710 (2013).","journal-title":"Adv. Nutr."},{"key":"1131_CR33","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.cmet.2024.11.010","volume":"37","author":"X Wang","year":"2024","unstructured":"Wang, X. et al. Adipocyte-derived ferroptotic signaling mitigates obesity. Cell Metab. 37, 673\u2013691 (2024).","journal-title":"Cell Metab."},{"key":"1131_CR34","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.chembiol.2018.11.016","volume":"26","author":"L Magtanong","year":"2019","unstructured":"Magtanong, L. et al. Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state. Cell Chem. Biol. 26, 420\u2013432 (2019).","journal-title":"Cell Chem. Biol."},{"key":"1131_CR35","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","volume":"185","author":"BR Stockwell","year":"2022","unstructured":"Stockwell, B. R. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell 185, 2401\u20132421 (2022).","journal-title":"Cell"},{"key":"1131_CR36","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nchembio.2238","volume":"13","author":"VE Kagan","year":"2016","unstructured":"Kagan, V. E. et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat. Chem. Biol. 13, 81\u201390 (2016).","journal-title":"Nat. Chem. Biol."},{"key":"1131_CR37","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","volume":"13","author":"S Doll","year":"2016","unstructured":"Doll, S. et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat. Chem. Biol. 13, 91\u201398 (2016).","journal-title":"Nat. Chem. Biol."},{"key":"1131_CR38","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1021\/acschembio.5b00245","volume":"10","author":"SJ Dixon","year":"2015","unstructured":"Dixon, S. J. et al. Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death. ACS Chem. Biol. 10, 1604\u20131609 (2015).","journal-title":"ACS Chem. Biol."},{"key":"1131_CR39","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1016\/j.cmet.2024.07.013","volume":"36","author":"L Tao","year":"2024","unstructured":"Tao, L. et al. Integrative clinical and preclinical studies identify FerroTerminator1 as a potent therapeutic drug for MASH. Cell Metab. 36, 2190\u20132206 (2024).","journal-title":"Cell Metab."},{"key":"1131_CR40","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41392-024-01962-6","volume":"9","author":"X Bi","year":"2024","unstructured":"Bi, X. et al. Characterization of ferroptosis-triggered pyroptotic signaling in heart failure. Signal. Transduct. Target. Ther. 9, 257 (2024).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"1131_CR41","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.7150\/ijbs.79853","volume":"19","author":"Q Wang","year":"2023","unstructured":"Wang, Q. et al. AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a\u2013ACSL4 axis-regulated ferroptosis. Int. J. Biol. Sci. 19, 1266\u20131283 (2023).","journal-title":"Int. J. Biol. Sci."},{"key":"1131_CR42","doi-asserted-by":"publisher","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","volume":"113","author":"WS Yang","year":"2016","unstructured":"Yang, W. S. et al. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc. Natl Acad. Sci. USA 113, E4966\u2013E4975 (2016).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1131_CR43","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.molcel.2020.11.024","volume":"81","author":"B Yan","year":"2021","unstructured":"Yan, B. et al. Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1. Mol. Cell 81, 355\u2013369 (2021).","journal-title":"Mol. Cell"},{"key":"1131_CR44","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2018.09.008","volume":"133","author":"DA Stoyanovsky","year":"2019","unstructured":"Stoyanovsky, D. A. et al. Iron catalysis of lipid peroxidation in ferroptosis: regulated enzymatic or random free radical reaction? Free Radic. Biol. Med. 133, 153\u2013161 (2019).","journal-title":"Free Radic. Biol. Med."},{"key":"1131_CR45","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1021\/acscentsci.7b00589","volume":"4","author":"R Shah","year":"2018","unstructured":"Shah, R., Shchepinov, M. S. & Pratt, D. A. Resolving the role of lipoxygenases in the initiation and execution of ferroptosis. ACS Cent. Sci. 4, 387\u2013396 (2018).","journal-title":"ACS Cent. Sci."},{"key":"1131_CR46","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.cell.2017.09.044","volume":"171","author":"SE Wenzel","year":"2017","unstructured":"Wenzel, S. E. et al. PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals. Cell 171, 628\u2013641 (2017).","journal-title":"Cell"},{"key":"1131_CR47","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.cmet.2024.01.006","volume":"36","author":"X Yang","year":"2024","unstructured":"Yang, X. et al. PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression. Cell Metab. 36, 762\u2013777 (2024).","journal-title":"Cell Metab."},{"key":"1131_CR48","doi-asserted-by":"publisher","first-page":"15916","DOI":"10.1007\/s12035-025-05257-x","volume":"62","author":"T Li","year":"2025","unstructured":"Li, T. et al. Deficiency of PLA2G6 induces ferroptosis in dopaminergic neurons and contributes to parkinson\u2019s disease pathogenesis via disruption of PRDX6\/FTH1\/GPX4 axis. Mol. Neurobiol. 62, 15916\u201315927 (2025).","journal-title":"Mol. Neurobiol."},{"key":"1131_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2025.159655","volume":"1870","author":"D Hayashi","year":"2025","unstructured":"Hayashi, D. et al. Specificity mechanism of Group VIA calcium-independent phospholipase A2 toward truncated-oxidized phospholipids and its application for specific inhibitor design. Biochim. Biophys. Acta 1870, 159655 (2025).","journal-title":"Biochim. Biophys. Acta"},{"key":"1131_CR50","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41589-020-00734-x","volume":"17","author":"W-Y Sun","year":"2021","unstructured":"Sun, W.-Y. et al. Phospholipase iPLA2\u03b2 averts ferroptosis by eliminating a redox lipid death signal. Nat. Chem. Biol. 17, 465\u2013476 (2021).","journal-title":"Nat. Chem. Biol."},{"key":"1131_CR51","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","volume":"12","author":"P Koppula","year":"2021","unstructured":"Koppula, P., Zhuang, L. & Gan, B. Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell 12, 599\u2013620 (2021).","journal-title":"Protein Cell"},{"key":"1131_CR52","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03135-z","volume":"11","author":"C Ding","year":"2020","unstructured":"Ding, C. et al. miR-182-5p and miR-378a-3p regulate ferroptosis in I\/R-induced renal injury. Cell Death Dis. 11, 929 (2020).","journal-title":"Cell Death Dis."},{"key":"1131_CR53","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","volume":"30","author":"BR Stockwell","year":"2020","unstructured":"Stockwell, B. R., Jiang, X. & Gu, W. Emerging mechanisms and disease relevance of ferroptosis. Trends Cell Biol. 30, 478\u2013490 (2020).","journal-title":"Trends Cell Biol."},{"key":"1131_CR54","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68603","volume":"10","author":"S Ide","year":"2021","unstructured":"Ide, S. et al. Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair. eLife 10, e68603 (2021).","journal-title":"eLife"},{"key":"1131_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111610","volume":"41","author":"S Ide","year":"2022","unstructured":"Ide, S. et al. Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair. Cell Rep. 41, 111610 (2022).","journal-title":"Cell Rep."},{"key":"1131_CR56","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41420-025-02557-y","volume":"11","author":"K Ye","year":"2025","unstructured":"Ye, K. et al. Roles of ACSL4\/GPX4 and FSP1 in oxalate-induced acute kidney injury. Cell Death Discov. 11, 279 (2025).","journal-title":"Cell Death Discov."},{"key":"1131_CR57","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang, W. S. et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 156, 317\u2013331 (2014).","journal-title":"Cell"},{"key":"1131_CR58","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1158\/0008-5472.CAN-24-3478","volume":"85","author":"SL DeAngelo","year":"2025","unstructured":"DeAngelo, S. L. et al. Recharacterization of the tumor suppressive mechanism of RSL3 identifies the selenoproteome as a druggable pathway in colorectal cancer. Cancer Res. 85, 2788\u20132804 (2025).","journal-title":"Cancer Res."},{"key":"1131_CR59","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","volume":"575","author":"S Doll","year":"2019","unstructured":"Doll, S. et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575, 693\u2013698 (2019).","journal-title":"Nature"},{"key":"1131_CR60","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","volume":"575","author":"K Bersuker","year":"2019","unstructured":"Bersuker, K. et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575, 688\u2013692 (2019).","journal-title":"Nature"},{"key":"1131_CR61","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/s41586-022-05022-3","volume":"608","author":"E Mishima","year":"2022","unstructured":"Mishima, E. et al. A non-canonical vitamin K cycle is a potent ferroptosis suppressor. Nature 608, 778\u2013783 (2022).","journal-title":"Nature"},{"key":"1131_CR62","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","volume":"6","author":"VAN Kraft","year":"2020","unstructured":"Kraft, V. A. N. et al. GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling. ACS Cent. Sci. 6, 41\u201353 (2020).","journal-title":"ACS Cent. Sci."},{"key":"1131_CR63","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1001\/jama.2016.5828","volume":"315","author":"A Zarbock","year":"2016","unstructured":"Zarbock, A. et al. Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the Elain randomized clinical trial. JAMA 315, 2190\u20132199 (2016).","journal-title":"JAMA"},{"key":"1131_CR64","doi-asserted-by":"publisher","first-page":"4551","DOI":"10.1021\/ja411006a","volume":"136","author":"R Skouta","year":"2014","unstructured":"Skouta, R. et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J. Am. Chem. Soc. 136, 4551\u20134556 (2014).","journal-title":"J. Am. Chem. Soc."},{"key":"1131_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24712-6","volume":"12","author":"W Tonnus","year":"2021","unstructured":"Tonnus, W. et al. Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury. Nat. Commun. 12, 4402 (2021).","journal-title":"Nat. Commun."},{"key":"1131_CR66","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1093\/jpp\/rgae050","volume":"76","author":"Z Song","year":"2024","unstructured":"Song, Z. et al. Protopanaxadiol prevents cisplatin-induced acute kidney injury by regulating ferroptosis. J. Pharm. Pharmacol. 76, 884\u2013896 (2024).","journal-title":"J. Pharm. Pharmacol."},{"key":"1131_CR67","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2025.1430946","volume":"16","author":"M Hanna","year":"2025","unstructured":"Hanna, M. et al. Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage. Front. Physiol. 16, 1430946 (2025).","journal-title":"Front. Physiol."},{"key":"1131_CR68","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1681\/ASN.2014101037","volume":"26","author":"Y Scindia","year":"2015","unstructured":"Scindia, Y. et al. Hepcidin mitigates renal ischemia\u2013reperfusion injury by modulating systemic iron homeostasis. J. Am. Soc. Nephrol. 26, 2800\u20132814 (2015).","journal-title":"J. Am. Soc. Nephrol."},{"key":"1131_CR69","doi-asserted-by":"publisher","first-page":"5033","DOI":"10.1172\/JCI129903","volume":"129","author":"F Deng","year":"2019","unstructured":"Deng, F., Sharma, I., Dai, Y., Yang, M. & Kanwar, Y. S. Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule. J. Clin. Invest. 129, 5033\u20135049 (2019).","journal-title":"J. Clin. Invest."},{"key":"1131_CR70","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400305","volume":"11","author":"H Zhu","year":"2024","unstructured":"Zhu, H. et al. SNORD3A regulates STING transcription to promote ferroptosis in acute kidney injury. Adv. Sci. 11, 2400305 (2024).","journal-title":"Adv. Sci."},{"key":"1131_CR71","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.680544","volume":"12","author":"X Li","year":"2021","unstructured":"Li, X. et al. A-lipoic acid alleviates folic acid-induced renal damage through inhibition of ferroptosis. Front. Physiol. 12, 680544 (2021).","journal-title":"Front. Physiol."},{"key":"1131_CR72","doi-asserted-by":"publisher","first-page":"99","DOI":"10.15586\/aei.v51i2.760","volume":"51","author":"Z Zhou","year":"2023","unstructured":"Zhou, Z. & Zhang, H. CHAC1 exacerbates LPS-induced ferroptosis and apoptosis in HK-2 cells by promoting oxidative stress. Allergol. Immunopathol. 51, 99\u2013110 (2023).","journal-title":"Allergol. Immunopathol."},{"key":"1131_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102262","volume":"51","author":"Y Wang","year":"2022","unstructured":"Wang, Y. et al. ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury. Redox Biol. 51, 102262 (2022).","journal-title":"Redox Biol."},{"key":"1131_CR74","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s10620-020-06225-2","volume":"66","author":"D Ma","year":"2021","unstructured":"Ma, D. et al. Inhibition of ferroptosis attenuates acute kidney injury in rats with severe acute pancreatitis. Dig. Dis. Sci. 66, 483\u2013492 (2021).","journal-title":"Dig. Dis. Sci."},{"key":"1131_CR75","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1330376","volume":"15","author":"X Huang","year":"2024","unstructured":"Huang, X. et al. Aristolochic acid induces acute kidney injury through ferroptosis. Front. Pharmacol. 15, 1330376 (2024).","journal-title":"Front. Pharmacol."},{"key":"1131_CR76","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03362-4","volume":"12","author":"C Chen","year":"2021","unstructured":"Chen, C. et al. Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI. Cell Death Dis. 12, 65 (2021).","journal-title":"Cell Death Dis."},{"key":"1131_CR77","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155757","volume":"130","author":"S Guo","year":"2024","unstructured":"Guo, S. et al. Baicalein alleviates cisplatin-induced acute kidney injury by inhibiting ALOX12-dependent ferroptosis. Phytomedicine 130, 155757 (2024).","journal-title":"Phytomedicine"},{"key":"1131_CR78","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2410628121","volume":"121","author":"J Zhang","year":"2024","unstructured":"Zhang, J. et al. RIPK4 promotes oxidative stress and ferroptotic death through the downregulation of ACSM1. Proc. Natl Acad. Sci. USA 121, e2410628121 (2024).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1131_CR79","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1681\/ASN.2015121376","volume":"28","author":"D Martin-Sanchez","year":"2017","unstructured":"Martin-Sanchez, D. et al. Ferroptosis, but not necroptosis, is important in nephrotoxic folic acid-induced AKI. J. Am. Soc. Nephrol. 28, 218\u2013229 (2017).","journal-title":"J. Am. Soc. Nephrol."},{"key":"1131_CR80","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41421-023-00595-3","volume":"9","author":"Z Cai","year":"2023","unstructured":"Cai, Z. et al. Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis. Cell Discov. 9, 104 (2023).","journal-title":"Cell Discov."},{"key":"1131_CR81","first-page":"5","volume":"34","author":"LP Kolligundla","year":"2025","unstructured":"Kolligundla, L. P. et al. Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis. Sci. Transl. Med. 34, 5 (2025).","journal-title":"Sci. Transl. Med."},{"key":"1131_CR82","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1038\/s41418-023-01198-x","volume":"30","author":"X Li","year":"2023","unstructured":"Li, X. et al. Small extracellular vesicles delivering lncRNA WAC-AS1 aggravate renal allograft ischemia-reperfusion injury by inducing ferroptosis propagation. Cell Death Differ. 30, 2167\u20132186 (2023).","journal-title":"Cell Death Differ."},{"key":"1131_CR83","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06236-7","volume":"14","author":"D Zhong","year":"2023","unstructured":"Zhong, D. et al. Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53. Cell Death Dis. 14, 710 (2023).","journal-title":"Cell Death Dis."},{"key":"1131_CR84","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06216-x","volume":"14","author":"Y Liu","year":"2023","unstructured":"Liu, Y. et al. Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1\u03b1\/HO-1 mediated ferroptosis. Cell Death Dis. 14, 694 (2023).","journal-title":"Cell Death Dis."},{"key":"1131_CR85","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.abb.2009.08.008","volume":"490","author":"T Shibasaki","year":"2009","unstructured":"Shibasaki, T. et al. Aggravation of ischemia-reperfusion-triggered acute renal failure in xCT-deficient mice. Arch. Biochem. Biophys. 490, 63\u201369 (2009).","journal-title":"Arch. Biochem. Biophys."},{"key":"1131_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102826","volume":"65","author":"Z Deng","year":"2023","unstructured":"Deng, Z. et al. WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury. Redox Biol. 65, 102826 (2023).","journal-title":"Redox Biol."},{"key":"1131_CR87","doi-asserted-by":"publisher","first-page":"103417","DOI":"10.1016\/j.redox.2024.103417","volume":"78","author":"Q Zheng","year":"2024","unstructured":"Zheng, Q., Xing, J., Li, X., Tang, X. & Zhang, D. PRDM16 suppresses ferroptosis to protect against sepsis-associated acute kidney injury by targeting the NRF2\/GPX4 axis. Redox Biol. 78, 103417 (2024).","journal-title":"Redox Biol."},{"key":"1131_CR88","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102939","volume":"68","author":"L Zhang","year":"2023","unstructured":"Zhang, L. et al. HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI\u2013CKD progression. Redox Biol. 68, 102939 (2023).","journal-title":"Redox Biol."},{"key":"1131_CR89","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44228-5","volume":"14","author":"L-K Chu","year":"2023","unstructured":"Chu, L.-K. et al. Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury. Nat. Commun. 14, 8393 (2023).","journal-title":"Nat. Commun."},{"key":"1131_CR90","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.166001","volume":"8","author":"S Gong","year":"2023","unstructured":"Gong, S. et al. REST contributes to AKI-to-CKD transition through inducing ferroptosis in renal tubular epithelial cells. JCI Insight 8, e166001 (2023).","journal-title":"JCI Insight"},{"key":"1131_CR91","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.kint.2024.05.009","volume":"106","author":"C Reichardt","year":"2024","unstructured":"Reichardt, C. et al. DNA-binding protein-A promotes kidney ischemia\/reperfusion injury and participates in mitochondrial function. Kidney Int. 106, 241\u2013257 (2024).","journal-title":"Kidney Int."},{"key":"1131_CR92","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07438-x","volume":"16","author":"J Huang","year":"2025","unstructured":"Huang, J. et al. Tubular CD44 plays a key role in aggravating AKI through NF-\u03baB p65-mediated mitochondrial dysfunction. Cell Death Dis. 16, 119 (2025).","journal-title":"Cell Death Dis."},{"key":"1131_CR93","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/s41418-024-01381-8","volume":"32","author":"K Lai","year":"2024","unstructured":"Lai, K. et al. The IDH1\u2013R132H mutation aggravates cisplatin-induced acute kidney injury by promoting ferroptosis through disrupting NDUFA1 and FSP1 interaction. Cell Death Differ. 32, 242\u2013255 (2024).","journal-title":"Cell Death Differ."},{"key":"1131_CR94","doi-asserted-by":"publisher","first-page":"102973","DOI":"10.1016\/j.redox.2023.102973","volume":"69","author":"F Cai","year":"2024","unstructured":"Cai, F. et al. Sulfide:quinone oxidoreductase alleviates ferroptosis in acute kidney injury via ameliorating mitochondrial dysfunction of renal tubular epithelial cells. Redox Biol. 69, 102973 (2024).","journal-title":"Redox Biol."},{"key":"1131_CR95","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.7150\/ijbs.80775","volume":"19","author":"Q Lin","year":"2023","unstructured":"Lin, Q. et al. Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS\/HO-1\/GPX4 axis. Int. J. Biol. Sci. 19, 1192\u20131210 (2023).","journal-title":"Int. J. Biol. Sci."},{"key":"1131_CR96","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21848","volume":"9","author":"Z Abolhassanzadeh","year":"2023","unstructured":"Abolhassanzadeh, Z. et al. The nephrotoxicity of Aristolochia rotunda L. in rats: mitochondrion as a target for renal toxicity of aristolochic acids-containing plants. Heliyon 9, e21848 (2023).","journal-title":"Heliyon"},{"key":"1131_CR97","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/s41589-023-01512-1","volume":"20","author":"Z Zhang","year":"2024","unstructured":"Zhang, Z. et al. CGI1746 targets \u03c31R to modulate ferroptosis through mitochondria-associated membranes. Nat. Chem. Biol. 20, 699\u2013709 (2024).","journal-title":"Nat. Chem. Biol."},{"key":"1131_CR98","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.2174\/0929867330666230607125054","volume":"31","author":"J Guo","year":"2024","unstructured":"Guo, J., Chen, L. & Ma, M. Ginsenoside Rg1 suppresses ferroptosis of renal tubular epithelial cells in sepsis-induced acute kidney injury via the FSP1\u2013CoQ10\u2013NAD(P)H pathway. Curr. Med. Chem. 31, 2119\u20132132 (2024).","journal-title":"Curr. Med. Chem."},{"key":"1131_CR99","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2024.2430929","volume":"29","author":"J Huang","year":"2024","unstructured":"Huang, J. et al. Dexmedetomidine inhibits ferroptosis and attenuates sepsis-induced acute kidney injury via activating the Nrf2\/SLC7A11\/FSP1\/CoQ10 pathway. Redox Rep. 29, 2430929 (2024).","journal-title":"Redox Rep."},{"key":"1131_CR100","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.3390\/antiox11122443","volume":"11","author":"S Wang","year":"2022","unstructured":"Wang, S., Zheng, Y., Jin, S., Fu, Y. & Liu, Y. Dioscin protects against cisplatin-induced acute kidney injury by reducing ferroptosis and apoptosis through activating Nrf2\/HO-1 signaling. Antioxidants 11, 2443 (2022).","journal-title":"Antioxidants"},{"key":"1131_CR101","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.112200","volume":"138","author":"L Zhang","year":"2026","unstructured":"Zhang, L. et al. Regulating the GTP cyclohydrolase 1\/tetrahydrobiopterin axis in the distal tubule inhibits ferroptosis and alleviates crush syndrome-related acute kidney injury in mice. Cell. Signal. 138, 112200 (2026).","journal-title":"Cell. Signal."},{"key":"1131_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103042","volume":"70","author":"X Wang","year":"2024","unstructured":"Wang, X. et al. Human proximal tubular epithelial cell-derived small extracellular vesicles mediate synchronized tubular ferroptosis in hypoxic kidney injury. Redox Biol. 70, 103042 (2024).","journal-title":"Redox Biol."},{"key":"1131_CR103","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/s41589-023-01528-7","volume":"20","author":"Q Zhang","year":"2024","unstructured":"Zhang, Q. et al. PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury. Nat. Chem. Biol. 20, 835\u2013846 (2024).","journal-title":"Nat. Chem. Biol."},{"key":"1131_CR104","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm0142","volume":"8","author":"A Lau","year":"2022","unstructured":"Lau, A. et al. Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury. Sci. Adv. 8, eabm0142 (2022).","journal-title":"Sci. Adv."},{"key":"1131_CR105","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl8920","volume":"8","author":"A von Massenhausen","year":"2022","unstructured":"von Massenhausen, A. et al. Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion. Sci. Adv. 8, eabl8920 (2022).","journal-title":"Sci. Adv."},{"key":"1131_CR106","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202300379","volume":"62","author":"F Zeng","year":"2023","unstructured":"Zeng, F. et al. Ferroptosis detection: from approaches to applications. Angew. Chem. Int. Ed. 62, e202300379 (2023).","journal-title":"Angew. Chem. Int. Ed."},{"key":"1131_CR107","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add8539","volume":"9","author":"F Zeng","year":"2023","unstructured":"Zeng, F. et al. Ferroptosis MRI for early detection of anticancer drug-induced acute cardiac\/kidney injuries. Sci. Adv. 9, eadd8539 (2023).","journal-title":"Sci. Adv."},{"key":"1131_CR108","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202311397","volume":"36","author":"W Zhang","year":"2024","unstructured":"Zhang, W. et al. Discovering a new drug against acute kidney injury by using a tailored photoacoustic imaging probe. Adv. Mater. 36, e2311397 (2024).","journal-title":"Adv. Mater."},{"key":"1131_CR109","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202500273","volume":"14","author":"Z Lv","year":"2025","unstructured":"Lv, Z. et al. Protein-interference-free and kidney-targeting NIR fluorophores for accurate in vivo imaging of H2S2 during kidney ferroptosis. Adv. Healthc. Mater. 14, e2500273 (2025).","journal-title":"Adv. Healthc. Mater."},{"key":"1131_CR110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/8598253","volume":"2016","author":"KP Poulianiti","year":"2016","unstructured":"Poulianiti, K. P. et al. Systemic redox imbalance in chronic kidney disease: a systematic review. Oxid. Med. Cell. Longev. 2016, 1\u201319 (2016).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"1131_CR111","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27107-8","volume":"8","author":"S van Raaij","year":"2018","unstructured":"van Raaij, S. et al. Tubular iron deposition and iron handling proteins in human healthy kidney and chronic kidney disease. Sci. Rep. 8, 9353 (2018).","journal-title":"Sci. Rep."},{"key":"1131_CR112","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/s41581-023-00741-w","volume":"19","author":"A Mitrofanova","year":"2023","unstructured":"Mitrofanova, A., Merscher, S. & Fornoni, A. Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease. Nat. Rev. Nephrol. 19, 629\u2013645 (2023).","journal-title":"Nat. Rev. Nephrol."},{"key":"1131_CR113","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06780-w","volume":"15","author":"X Li","year":"2024","unstructured":"Li, X. et al. HOXD10 attenuates renal fibrosis by inhibiting NOX4-induced ferroptosis. Cell Death Dis. 15, 398 (2024).","journal-title":"Cell Death Dis."},{"key":"1131_CR114","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14275","volume":"23","author":"L Wu","year":"2024","unstructured":"Wu, L. et al. Macrophage iron dyshomeostasis promotes aging-related renal fibrosis. Aging Cell 23, e14275 (2024).","journal-title":"Aging Cell"},{"key":"1131_CR115","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173574","volume":"888","author":"Y Wang","year":"2020","unstructured":"Wang, Y. et al. Ferroptosis involves in renal tubular cell death in diabetic nephropathy. Eur. J. Pharmacol. 888, 173574 (2020).","journal-title":"Eur. J. Pharmacol."},{"key":"1131_CR116","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/s41392-023-01313-x","volume":"8","author":"X Du","year":"2023","unstructured":"Du, X. et al. B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis. Signal. Transduct. Target. Ther. 8, 103 (2023).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"1131_CR117","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2022.109213","volume":"248","author":"AA Alli","year":"2023","unstructured":"Alli, A. A. et al. Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis. Clin. Immunol. 248, 109213 (2023).","journal-title":"Clin. Immunol."},{"key":"1131_CR118","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305563","volume":"11","author":"H Wang","year":"2023","unstructured":"Wang, H. et al. VDR activation attenuates renal tubular epithelial cell ferroptosis by regulating Nrf2\/HO-1 signaling pathway in diabetic nephropathy. Adv. Sci. 11, e2305563 (2023).","journal-title":"Adv. Sci."},{"key":"1131_CR119","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1053\/ajkd.2001.28593","volume":"38","author":"H Wang","year":"2001","unstructured":"Wang, H. et al. Iron deposition in renal biopsy specimens from patients with kidney diseases. Am. J. Kidney Dis. 38, 1038\u20131044 (2001).","journal-title":"Am. J. Kidney Dis."},{"key":"1131_CR120","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.3390\/nu16131978","volume":"16","author":"J Zhou","year":"2024","unstructured":"Zhou, J. et al. Mendelian randomization analysis of systemic iron status and risk of different types of kidney disease. Nutrients 16, 1978 (2024).","journal-title":"Nutrients"},{"key":"1131_CR121","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.159235","volume":"8","author":"E Patino","year":"2023","unstructured":"Patino, E. et al. Iron therapy mitigates chronic kidney disease progression by regulating intracellular iron status of kidney macrophages. JCI Insight 8, e159235 (2023).","journal-title":"JCI Insight"},{"key":"1131_CR122","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/ki.2015.102","volume":"88","author":"S Bolisetty","year":"2015","unstructured":"Bolisetty, S. et al. Macrophage and epithelial cell H-ferritin expression regulates renal inflammation. Kidney Int. 88, 95\u2013108 (2015).","journal-title":"Kidney Int."},{"key":"1131_CR123","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202408945","volume":"11","author":"C Duan","year":"2024","unstructured":"Duan, C. et al. Sirtuin1 suppresses calcium oxalate nephropathy via inhibition of renal proximal tubular cell ferroptosis through PGC-1\u03b1-mediated transcriptional coactivation. Adv. Sci. 11, e2408945 (2024).","journal-title":"Adv. Sci."},{"key":"1131_CR124","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s42003-023-05272-5","volume":"6","author":"Y Dai","year":"2023","unstructured":"Dai, Y. et al. Inhibition of ACSL4 ameliorates tubular ferroptotic cell death and protects against fibrotic kidney disease. Commun. Biol. 6, 907 (2023).","journal-title":"Commun. Biol."},{"key":"1131_CR125","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s10020-023-00732-4","volume":"29","author":"C Yang","year":"2023","unstructured":"Yang, C. et al. Research progress on multiple cell death pathways of podocytes in diabetic kidney disease. Mol. Med. 29, 135 (2023).","journal-title":"Mol. Med."},{"key":"1131_CR126","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s12038-023-00381-z","volume":"49","author":"J Chen","year":"2024","unstructured":"Chen, J. et al. STING upregulation mediates ferroptosis and inflammatory response in lupus nephritis by upregulating TBK1 and activating NF-\u03baB signal pathway. J. Biosci. 49, 9 (2024).","journal-title":"J. Biosci."},{"key":"1131_CR127","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403992","volume":"12","author":"C Dong","year":"2025","unstructured":"Dong, C. et al. CHAC1 mediates endoplasmic reticulum stress-dependent ferroptosis in calcium oxalate kidney stone formation. Adv. Sci. 12, e2403992 (2025).","journal-title":"Adv. Sci."},{"key":"1131_CR128","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1016\/j.ymthe.2023.07.026","volume":"31","author":"L Gao","year":"2023","unstructured":"Gao, L. et al. STING\/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease. Mol. Ther. 31, 3084\u20133103 (2023).","journal-title":"Mol. Ther."},{"key":"1131_CR129","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1038\/s41418-024-01357-8","volume":"31","author":"J Hong","year":"2024","unstructured":"Hong, J. et al. The PRMT6\/STAT1\/ACSL1 axis promotes ferroptosis in diabetic nephropathy. Cell Death Differ. 31, 1561\u20131575 (2024).","journal-title":"Cell Death Differ."},{"key":"1131_CR130","doi-asserted-by":"publisher","first-page":"5438","DOI":"10.7150\/ijbs.74675","volume":"18","author":"J Wu","year":"2022","unstructured":"Wu, J. et al. Downregulation of PPAR\u03b1 mediates FABP1 expression, contributing to IgA nephropathy by stimulating ferroptosis in human mesangial cells. Int. J. Biol. Sci. 18, 5438\u20135458 (2022).","journal-title":"Int. J. Biol. Sci."},{"key":"1131_CR131","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.2337\/diabetes.52.5.1204","volume":"52","author":"FS Facchini","year":"2003","unstructured":"Facchini, F. S. & Saylor, K. L. A low-iron-available, polyphenol-enriched, carbohydrate-restricted diet to slow progression of diabetic nephropathy. Diabetes 52, 1204\u20131209 (2003).","journal-title":"Diabetes"},{"key":"1131_CR132","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1038\/s41590-021-00993-3","volume":"22","author":"P Li","year":"2021","unstructured":"Li, P. et al. Glutathione peroxidase 4\u2013regulated neutrophil ferroptosis induces systemic autoimmunity. Nat. Immunol. 22, 1107\u20131117 (2021).","journal-title":"Nat. Immunol."},{"key":"1131_CR133","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.eururo.2016.02.029","volume":"70","author":"H Moch","year":"2016","unstructured":"Moch, H., Cubilla, A. L., Humphrey, P. A., Reuter, V. E. & Ulbright, T. M. The 2016 WHO classification of tumours of the urinary system and male genital organs-part a: renal, penile, and testicular tumours. Eur. Urol. 70, 93\u2013105 (2016).","journal-title":"Eur. Urol."},{"key":"1131_CR134","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06057-8","volume":"14","author":"W Xue","year":"2023","unstructured":"Xue, W. et al. Knockdown of SETD2 promotes erastin-induced ferroptosis in ccRCC. Cell Death Dis. 14, 539 (2023).","journal-title":"Cell Death Dis."},{"key":"1131_CR135","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09277-9","volume":"10","author":"Y Zou","year":"2019","unstructured":"Zou, Y. et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nat. Commun. 10, 1617 (2019).","journal-title":"Nat. Commun."},{"key":"1131_CR136","doi-asserted-by":"publisher","first-page":"5435","DOI":"10.1038\/s41388-018-0315-z","volume":"37","author":"H Miess","year":"2018","unstructured":"Miess, H. et al. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene 37, 5435\u20135450 (2018).","journal-title":"Oncogene"},{"key":"1131_CR137","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-025-07698-7","volume":"16","author":"Y Wang","year":"2025","unstructured":"Wang, Y. et al. Integrated analysis of MIOX gene in prognosis of clear-cell renal cell carcinoma. Cell Death Dis. 16, 368 (2025).","journal-title":"Cell Death Dis."},{"key":"1131_CR138","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02122-8","volume":"24","author":"Y Wang","year":"2025","unstructured":"Wang, Y. et al. circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4. Mol. Cancer. 24, 1 (2025).","journal-title":"Mol. Cancer."},{"key":"1131_CR139","doi-asserted-by":"publisher","first-page":"3940","DOI":"10.1158\/0008-5472.CAN-22-4001","volume":"83","author":"K Chang","year":"2023","unstructured":"Chang, K. et al. DPP9 stabilizes NRF2 to suppress ferroptosis and induce sorafenib resistance in clear cell renal cell carcinoma. Cancer Res. 83, 3940\u20133955 (2023).","journal-title":"Cancer Res."},{"key":"1131_CR140","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1038\/s41418-023-01176-3","volume":"30","author":"S Wang","year":"2023","unstructured":"Wang, S. et al. The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma. Cell Death Differ. 30, 1757\u20131770 (2023).","journal-title":"Cell Death Differ."},{"key":"1131_CR141","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41572-018-0047-y","volume":"4","author":"C Bergmann","year":"2018","unstructured":"Bergmann, C. et al. Polycystic kidney disease. Nat. Rev. Dis. Primers 4, 50 (2018).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"1131_CR142","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.141299","volume":"6","author":"PS Radadiya","year":"2021","unstructured":"Radadiya, P. S. et al. Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease. JCI Insight 6, e141299 (2021).","journal-title":"JCI Insight"},{"key":"1131_CR143","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aba3613","volume":"12","author":"Y Lu","year":"2020","unstructured":"Lu, Y. et al. Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease. Sci. Transl. Med. 12, eaba3613 (2020).","journal-title":"Sci. Transl. Med."},{"key":"1131_CR144","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1681\/ASN.2021040460","volume":"32","author":"X Zhang","year":"2021","unstructured":"Zhang, X. et al. Ferroptosis promotes cyst growth in autosomal dominant polycystic kidney disease mouse models. J. Am. Soc. Nephrol. 32, 2759\u20132776 (2021).","journal-title":"J. Am. Soc. Nephrol."},{"key":"1131_CR145","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06185-1","volume":"14","author":"W Hao","year":"2023","unstructured":"Hao, W. et al. Critical role of VHL\/BICD2\/STAT1 axis in crystal-associated kidney disease. Cell Death Dis. 14, 680 (2023).","journal-title":"Cell Death Dis."},{"key":"1131_CR146","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1182\/blood.V4.11.1183.1183","volume":"4","author":"JV Dacie","year":"1949","unstructured":"Dacie, J. V. Diagnosis and mechanism of hemolysis in chronic hemolytic anemia with nocturnal hemoglobinuria. Blood 4, 1183\u20131195 (1949).","journal-title":"Blood"},{"key":"1131_CR147","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/j.1600-0609.2011.01615.x","volume":"87","author":"JJ Pu","year":"2011","unstructured":"Pu, J. J., Mukhina, G., Wang, H., Savage, W. J. & Brodsky, R. A. Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia. Eur. J. Haematol. 87, 37\u201345 (2011).","journal-title":"Eur. J. Haematol."},{"key":"1131_CR148","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/0092-8674(93)90250-T","volume":"73","author":"J Takeda","year":"1993","unstructured":"Takeda, J. et al. Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell 73, 703\u2013711 (1993).","journal-title":"Cell"},{"key":"1131_CR149","doi-asserted-by":"publisher","first-page":"289","DOI":"10.4103\/0971-4065.205201","volume":"27","author":"R Ram","year":"2017","unstructured":"Ram, R., Adiraju, K. P., Gudithi, S. & Dakshinamurty, K. V. Renal manifestations in paroxysmal nocturnal hemoglobinuria. Indian J. Nephrol. 27, 289 (2017).","journal-title":"Indian J. Nephrol."},{"key":"1131_CR150","first-page":"116","volume":"5","author":"MR Balwani","year":"2016","unstructured":"Balwani, M. R. et al. Manifestation of paroxysmal nocturnalhemoglobinuria as repeated acute kidney injury. J. Nephropharmacol. 5, 116\u2013118 (2016).","journal-title":"J. Nephropharmacol."},{"key":"1131_CR151","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s11255-008-9356-5","volume":"40","author":"RK Nair","year":"2008","unstructured":"Nair, R. K., Khaira, A., Sharma, A., Mahajan, S. & Dinda, A. K. Spectrum of renal involvement in paroxysmal nocturnal hemoglobinuria: report of three cases and a brief review of the literature. Int. Urol. Nephrol. 40, 471\u2013475 (2008).","journal-title":"Int. Urol. Nephrol."},{"key":"1131_CR152","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1182\/blood.V57.1.83.83","volume":"57","author":"DA Clark","year":"1981","unstructured":"Clark, D. A., Butler, S. A., Braren, V., Hartmann, R. C. & Jenkins, D. E. The kidneys in paroxysmal-nocturnal hemoglobinuria. Blood 57, 83\u201389 (1981).","journal-title":"Blood"},{"key":"1131_CR153","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13045-019-0720-y","volume":"12","author":"Y Mou","year":"2019","unstructured":"Mou, Y. et al. Ferroptosis, a new form of cell death: opportunities and challenges in cancer. J. Hematol. Oncol. 12, 34 (2019).","journal-title":"J. Hematol. Oncol."},{"key":"1131_CR154","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.chom.2018.05.009","volume":"24","author":"R Kang","year":"2018","unstructured":"Kang, R. et al. Lipid peroxidation drives gasdermin D-mediated pyroptosis in lethal polymicrobial sepsis. Cell Host Microbe 24, 97\u2013108 (2018).","journal-title":"Cell Host Microbe"},{"key":"1131_CR155","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","volume":"1863","author":"SM Ahmed","year":"2017","unstructured":"Ahmed, S. M., Luo, L., Namani, A., Wang, X. J. & Tang, X. Nrf2 signaling pathway: pivotal roles in inflammation. Biochim. Biophys. Acta Mol. Basis Dis. 1863, 585\u2013597 (2017).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"1131_CR156","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","volume":"18","author":"Y Huang","year":"2021","unstructured":"Huang, Y., Xu, W. & Zhou, R. NLRP3 inflammasome activation and cell death. Cell. Mol. Immunol. 18, 2114\u20132127 (2021).","journal-title":"Cell. Mol. Immunol."},{"key":"1131_CR157","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40037-y","volume":"14","author":"L Bordoni","year":"2023","unstructured":"Bordoni, L. et al. Longitudinal tracking of acute kidney injury reveals injury propagation along the nephron. Nat. Commun. 14, 4407 (2023).","journal-title":"Nat. Commun."},{"key":"1131_CR158","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/s41586-024-07623-6","volume":"631","author":"HKC Co","year":"2024","unstructured":"Co, H. K. C., Wu, C.-C., Lee, Y.-C. & Chen, S. -h Emergence of large-scale cell death through ferroptotic trigger waves. Nature 631, 654\u2013662 (2024).","journal-title":"Nature"},{"key":"1131_CR159","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1038\/s41556-020-0565-1","volume":"22","author":"M Riegman","year":"2020","unstructured":"Riegman, M. et al. Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture. Nat. Cell Biol. 22, 1042\u20131048 (2020).","journal-title":"Nat. Cell Biol."},{"key":"1131_CR160","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58175-w","volume":"16","author":"BF Roeck","year":"2025","unstructured":"Roeck, B. F. et al. Ferroptosis spreads to neighboring cells via plasma membrane contacts. Nat. Commun. 16, 2951 (2025).","journal-title":"Nat. Commun."},{"key":"1131_CR161","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.1073\/pnas.1716578115","volume":"115","author":"D Martin-Sanchez","year":"2018","unstructured":"Martin-Sanchez, D. et al. TWEAK and RIPK1 mediate a second wave of cell death during AKI. Proc. Natl Acad. Sci. USA 115, 4182\u20134187 (2018).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1131_CR162","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1042\/CS20171592","volume":"132","author":"M Buonafine","year":"2018","unstructured":"Buonafine, M., Martinez-Martinez, E. & Jaisser, F. More than a simple biomarker: the role of NGAL in cardiovascular and renal diseases. Clin. Sci. 132, 909\u2013923 (2018).","journal-title":"Clin. Sci."},{"key":"1131_CR163","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nm.2290","volume":"17","author":"N Paragas","year":"2011","unstructured":"Paragas, N. et al. The Ngal reporter mouse detects the response of the kidney to injury in real time. Nat. Med. 17, 216\u2013222 (2011).","journal-title":"Nat. Med."},{"key":"1131_CR164","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.cell.2005.10.027","volume":"123","author":"LR Devireddy","year":"2005","unstructured":"Devireddy, L. R., Gazin, C., Zhu, X. & Green, M. R. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 123, 1293\u20131305 (2005).","journal-title":"Cell"},{"key":"1131_CR165","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S1097-2765(02)00708-6","volume":"10","author":"DH Goetz","year":"2002","unstructured":"Goetz, D. H. et al. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol. Cell 10, 1033\u20131043 (2002).","journal-title":"Mol. Cell"},{"key":"1131_CR166","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1073\/pnas.0510847103","volume":"103","author":"T Berger","year":"2006","unstructured":"Berger, T. et al. Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc. Natl Acad. Sci. USA 103, 1834\u20131839 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1131_CR167","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/nchembio.402","volume":"6","author":"G Bao","year":"2010","unstructured":"Bao, G. et al. Iron traffics in circulation bound to a siderocalin (Ngal)\u2013catechol complex. Nat. Chem. Biol. 6, 602\u2013609 (2010).","journal-title":"Nat. Chem. Biol."},{"key":"1131_CR168","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1172\/JCI23056","volume":"115","author":"K Mori","year":"2005","unstructured":"Mori, K. et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J. Clin. Invest. 115, 610\u2013621 (2005).","journal-title":"J. Clin. Invest."},{"key":"1131_CR169","doi-asserted-by":"publisher","first-page":"12169","DOI":"10.1080\/21655979.2022.2073144","volume":"13","author":"Y-J Song","year":"2022","unstructured":"Song, Y.-J. et al. Preliminary study on 24p3\/neutrophil gelatinase-associated lipocalin (NGAL) ferroptosis inhibition in renal tubular epithelial cells. Bioengineered 13, 12169\u201312181 (2022).","journal-title":"Bioengineered"},{"key":"1131_CR170","first-page":"556","volume":"16","author":"JV Bonventre","year":"2010","unstructured":"Bonventre, J. V. & Yang, L. Kidney injury molecule-1. Curr. Opin. Crit. Care 16, 556\u2013561 (2010).","journal-title":"Curr. Opin. Crit. Care"},{"key":"1131_CR171","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1172\/JCI75417","volume":"125","author":"L Yang","year":"2015","unstructured":"Yang, L. et al. KIM-1-mediated phagocytosis reduces acute injury to the kidney. J. Clin. Invest. 125, 1620\u20131636 (2015).","journal-title":"J. Clin. Invest."},{"key":"1131_CR172","doi-asserted-by":"publisher","first-page":"4023","DOI":"10.1172\/JCI45361","volume":"123","author":"BD Humphreys","year":"2013","unstructured":"Humphreys, B. D. et al. Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J. Clin. Invest. 123, 4023\u20134035 (2013).","journal-title":"J. Clin. Invest."},{"key":"1131_CR173","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.cmet.2021.04.004","volume":"33","author":"Y Mori","year":"2021","unstructured":"Mori, Y. et al. KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. Cell Metab. 33, 1042\u20131061 (2021).","journal-title":"Cell Metab."},{"key":"1131_CR174","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/S0140-6736(11)61454-2","volume":"380","author":"R Bellomo","year":"2012","unstructured":"Bellomo, R., Kellum, J. A. & Ronco, C. Acute kidney injury. Lancet 380, 756\u2013766 (2012).","journal-title":"Lancet"},{"key":"1131_CR175","first-page":"1460","volume":"37","author":"R Xu","year":"2021","unstructured":"Xu, R., Zhu, D., Guo, J. & Wang, C. IL-18 promotes erythrophagocytosis and erythrocyte degradation by M1 macrophages in a calcific microenvironment. Can. J. Cardiol. 37, 1460\u20131471 (2021).","journal-title":"Can. J. Cardiol."},{"key":"1131_CR176","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3109\/00016340903576020","volume":"89","author":"L Roland","year":"2010","unstructured":"Roland, L. et al. Plasma interleukin-18 (IL-18) levels are correlated with antioxidant vitamin coenzyme Q10 in preeclampsia. Acta Obstet. Gynecol. Scand. 89, 360\u2013366 (2010).","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"1131_CR177","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bbrc.2021.05.011","volume":"561","author":"GM Su","year":"2021","unstructured":"Su, G. M., Yang, W., Wang, S. J., Geng, C. H. & Guan, X. R. SIRT1\u2013autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1B and IL-18. Biochem. Biophys. Res. Commun. 561, 33\u201339 (2021).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"1131_CR178","doi-asserted-by":"publisher","first-page":"2894","DOI":"10.1681\/ASN.2007010097","volume":"18","author":"T Yamamoto","year":"2007","unstructured":"Yamamoto, T. et al. Renal L-type fatty acid\u2013binding protein in acute ischemic injury. J. Am. Soc. Nephrol. 18, 2894\u20132902 (2007).","journal-title":"J. Am. Soc. Nephrol."},{"key":"1131_CR179","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1097\/00007890-200004150-00032","volume":"69","author":"E S\u00e1rv\u00e1ry","year":"2000","unstructured":"S\u00e1rv\u00e1ry, E. et al. Prediction of early renal graft function by the measurement of donor urinary glutathione S-transferases. Transplantation 69, 1397\u20131402 (2000).","journal-title":"Transplantation"},{"key":"1131_CR180","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3109\/03602532.2011.558092","volume":"43","author":"LM Balogh","year":"2011","unstructured":"Balogh, L. M. & Atkins, W. M. Interactions of glutathione transferases with 4-hydroxynonenal. Drug Metab. Rev. 43, 165\u2013178 (2011).","journal-title":"Drug Metab. Rev."},{"key":"1131_CR181","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1002\/path.4067","volume":"228","author":"A Liang","year":"2012","unstructured":"Liang, A. et al. Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis. J. Pathol. 228, 448\u2013458 (2012).","journal-title":"J. Pathol."},{"key":"1131_CR182","doi-asserted-by":"publisher","first-page":"2536732","DOI":"10.1080\/0886022X.2025.2536732","volume":"47","author":"H Wang","year":"2025","unstructured":"Wang, H., Sun, J., Luo, Y., Li, X. & Li, J. The role of ferroptosis in acute kidney injury: the preemptive mode of cell death and the bridging effect. Ren. Fail. 47, 2536732 (2025).","journal-title":"Ren. Fail."},{"key":"1131_CR183","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adk1200","volume":"10","author":"Q Huang","year":"2024","unstructured":"Huang, Q. et al. Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases. Sci. Adv. 10, eadk1200 (2024).","journal-title":"Sci. Adv."},{"key":"1131_CR184","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jare.2020.07.007","volume":"28","author":"Y Wang","year":"2021","unstructured":"Wang, Y. et al. Quercetin alleviates acute kidney injury by inhibiting ferroptosis. J. Adv. Res. 28, 231\u2013243 (2021).","journal-title":"J. Adv. Res."},{"key":"1131_CR185","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.jcis.2024.10.198","volume":"680","author":"W Chen","year":"2025","unstructured":"Chen, W. et al. Fullerenols as efficient ferroptosis inhibitor by targeting lipid peroxidation for preventing drug-induced acute kidney injury. J. Colloid Interface Sci. 680, 261\u2013273 (2025).","journal-title":"J. Colloid Interface Sci."},{"key":"1131_CR186","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1038\/s42003-024-07377-x","volume":"7","author":"Y Ma","year":"2024","unstructured":"Ma, Y. et al. Chemerin attenuates acute kidney injury by inhibiting ferroptosis via the AMPK\/NRF2\/SLC7A11 axis. Commun. Biol. 7, 1679 (2024).","journal-title":"Commun. Biol."},{"key":"1131_CR187","doi-asserted-by":"publisher","first-page":"155407","DOI":"10.1016\/j.phymed.2024.155407","volume":"126","author":"F Cai","year":"2024","unstructured":"Cai, F., Li, D., Zhou, K., Zhang, W. & Yang, Y. Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2\u2013KEAP1 interaction. Phytomedicine 126, 155407 (2024).","journal-title":"Phytomedicine"},{"key":"1131_CR188","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2023.2290864","volume":"29","author":"H Zan","year":"2024","unstructured":"Zan, H. et al. Melittin alleviates sepsis-induced acute kidney injury by promoting GPX4 expression to inhibit ferroptosis. Redox Rep. 29, 2290864 (2024).","journal-title":"Redox Rep."},{"key":"1131_CR189","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156189","volume":"135","author":"J Zhu","year":"2024","unstructured":"Zhu, J. et al. Yi-Qi-Jian-Pi-Xiao-Yu formula inhibits cisplatin-induced acute kidney injury through suppressing ferroptosis via STING\u2013NCOA4-mediated ferritinophagy. Phytomedicine 135, 156189 (2024).","journal-title":"Phytomedicine"},{"key":"1131_CR190","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103360","volume":"77","author":"Y Deng","year":"2024","unstructured":"Deng, Y. et al. Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1. Redox Biol. 77, 103360 (2024).","journal-title":"Redox Biol."},{"key":"1131_CR191","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41586-025-09389-x","volume":"645","author":"W Tonnus","year":"2025","unstructured":"Tonnus, W. et al. Multiple oestradiol functions inhibit ferroptosis and acute kidney injury. Nature 645, 119 (2025).","journal-title":"Nature"},{"key":"1131_CR192","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31772-9","volume":"13","author":"MS Balzer","year":"2022","unstructured":"Balzer, M. S. et al. Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration. Nat. Commun. 13, 4018 (2022).","journal-title":"Nat. Commun."},{"key":"1131_CR193","doi-asserted-by":"publisher","first-page":"9735555","DOI":"10.1155\/2022\/9735555","volume":"2022","author":"B Huang","year":"2022","unstructured":"Huang, B., Wen, W. & Ye, S. Dapagliflozin ameliorates renal tubular ferroptosis in diabetes via SLC40A1 stabilization. Oxid. Med. Cell. Longev. 2022, 9735555 (2022).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"1131_CR194","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.freeradbiomed.2022.12.088","volume":"195","author":"Q Lu","year":"2023","unstructured":"Lu, Q. et al. Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK\/NRF2 pathway. Free Radic. Biol. Med. 195, 89\u2013102 (2023).","journal-title":"Free Radic. Biol. Med."},{"key":"1131_CR195","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409781","volume":"12","author":"S Tian","year":"2024","unstructured":"Tian, S. et al. GLP-1 receptor agonists alleviate diabetic kidney injury via \u03b2-klotho-mediated ferroptosis inhibition. Adv. Sci. 12, e2409781 (2024).","journal-title":"Adv. Sci."},{"key":"1131_CR196","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156738","volume":"141","author":"W-M Zhao","year":"2025","unstructured":"Zhao, W.-M. et al. Diosmin attenuates UUO-induced renal ferroptosis and fibrosis by inhibiting the HIF-1\u03b1\/FABP4 signaling axis. Phytomedicine 141, 156738 (2025).","journal-title":"Phytomedicine"},{"key":"1131_CR197","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156302","volume":"136","author":"Z Ye","year":"2025","unstructured":"Ye, Z. et al. Luteolin alleviated calcium oxalate crystal induced kidney injury by inhibiting Nr4a1-mediated ferroptosis. Phytomedicine 136, 156302 (2025).","journal-title":"Phytomedicine"},{"key":"1131_CR198","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s10020-022-00481-w","volume":"28","author":"H Tan","year":"2022","unstructured":"Tan, H. et al. Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF\/Akt\/ERK pathways. Mol. Med. 28, 58 (2022).","journal-title":"Mol. Med."},{"key":"1131_CR199","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113953","volume":"156","author":"J Chen","year":"2022","unstructured":"Chen, J. et al. Ginkgolide B alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy. Biomed. Pharmacother. 156, 113953 (2022).","journal-title":"Biomed. Pharmacother."},{"key":"1131_CR200","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1142\/S0192415X23500465","volume":"51","author":"Q Feng","year":"2023","unstructured":"Feng, Q. et al. Quercetin ameliorates diabetic kidney injury by inhibiting ferroptosis via activating Nrf2\/HO-1 signaling pathway. Am. J. Chin. Med. 51, 997\u20131018 (2023).","journal-title":"Am. J. Chin. Med."},{"key":"1131_CR201","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05719-x","volume":"14","author":"L Kang","year":"2023","unstructured":"Kang, L. et al. PDIA4 confers resistance to ferroptosis via induction of ATF4\/SLC7A11 in renal cell carcinoma. Cell Death Dis. 14, 193 (2023).","journal-title":"Cell Death Dis."},{"key":"1131_CR202","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05779-z","volume":"14","author":"J Hao","year":"2023","unstructured":"Hao, J. et al. Combination treatment with FAAH inhibitors\/URB597 and ferroptosis inducers significantly decreases the growth and metastasis of renal cell carcinoma cells via the PI3K\u2013AKT signaling pathway. Cell Death Dis. 14, 247 (2023).","journal-title":"Cell Death Dis."},{"key":"1131_CR203","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1166\/jbn.2022.3250","volume":"18","author":"W Ni","year":"2022","unstructured":"Ni, W. et al. Tumor microenvironment-responsive nanodrug for clear-cell renal cell carcinoma therapy via triggering Waterfall-like cascade ferroptosis. J. Biomed. Nanotechnol. 18, 327\u2013342 (2022).","journal-title":"J. Biomed. Nanotechnol."},{"key":"1131_CR204","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2021.145992","volume":"809","author":"W Yangyun","year":"2022","unstructured":"Yangyun, W. et al. Everolimus accelerates Erastin and RSL3-induced ferroptosis in renal cell carcinoma. Gene 809, 145992 (2022).","journal-title":"Gene"},{"key":"1131_CR205","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.kint.2025.05.030","volume":"108","author":"Q Xu","year":"2025","unstructured":"Xu, Q. et al. Kidney hepcidin protects the collecting duct against ferroptosis in ischemia\/reperfusion-induced acute kidney injury. Kidney Int. 108, 394\u2013410 (2025).","journal-title":"Kidney Int."},{"key":"1131_CR206","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.chembiol.2020.03.013","volume":"27","author":"BR Stockwell","year":"2020","unstructured":"Stockwell, B. R. & Jiang, X. The chemistry and biology of ferroptosis. Cell Chem. Biol. 27, 365\u2013375 (2020).","journal-title":"Cell Chem. Biol."},{"key":"1131_CR207","doi-asserted-by":"publisher","first-page":"1594702","DOI":"10.3389\/fmed.2025.1594702","volume":"12","author":"Z Gao","year":"2025","unstructured":"Gao, Z. & Du, J. Erastin-induced multi-pathway cell death in endometriosis: a mechanistic and translational narrative review. Front. Med. 12, 1594702 (2025).","journal-title":"Front. Med."},{"key":"1131_CR208","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.3390\/biom15121749","volume":"15","author":"L Chen","year":"2025","unstructured":"Chen, L., Chen, D., Yang, F., Chen, X. & Zheng, B. RSL3 promotes STAT3 ubiquitination to induce autophagy and apoptosis in PARPi-resistant breast cancer cells. Biomolecules 15, 1749 (2025).","journal-title":"Biomolecules"},{"key":"1131_CR209","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-11368-1","volume":"15","author":"WG Herrick","year":"2025","unstructured":"Herrick, W. G. et al. Potent ferroptosis agent RSL3 induces cleavage of pyroptosis-specific gasdermins in cancer cells. Sci. Rep. 15, 25249 (2025).","journal-title":"Sci. Rep."},{"key":"1131_CR210","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2300320120","volume":"120","author":"A Belavgeni","year":"2023","unstructured":"Belavgeni, A. et al. vPIF-1 is an insulin-like antiferroptotic viral peptide. Proc. Natl Acad. Sci. USA 120, e2300320120 (2023).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1131_CR211","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1360\/SSV-2023-0192","volume":"53","author":"F Wang","year":"2023","unstructured":"Wang, F. Ferrology: a charming boundless iron-centric science. Sci. Sin. Vitae 53, 1331\u20131344 (2023).","journal-title":"Sci. Sin. Vitae"},{"key":"1131_CR212","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","volume":"9","author":"Q Ru","year":"2024","unstructured":"Ru, Q. et al. Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects. Signal. Transduct. Target. Ther. 9, 271 (2024).","journal-title":"Signal. Transduct. Target. Ther."}],"container-title":["Nature Reviews Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41581-026-01131-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41581-026-01131-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41581-026-01131-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:01:26Z","timestamp":1789747286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41581-026-01131-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":212,"alternative-id":["1131"],"URL":"https:\/\/doi.org\/10.1038\/s41581-026-01131-8","relation":{},"ISSN":["1759-5061","1759-507X"],"issn-type":[{"value":"1759-5061","type":"print"},{"value":"1759-507X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]},"assertion":[{"value":"4 September 2026","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}