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F.V.T. was a subinvestigator for the IONIS ION373 Trial for Alexander\u2019s disease (2024\u20132025). G.B. is\/was a consultant for Calico (2023\u2013present), Orchard Therapeutics (2023), Passage Bio, Inc. (2020\u20132022) and Ionis (2019). G.B. is\/was a site investigator\/subinvestigator for trials from Ionis (2021\u2013present), Shire\/Takeda (2020\u20132021), Passage Bio (2021\u20132024), Bluebird Bio (2019), Regenxbio (2021\u20132024) and Denali (2022-present). G.B. has two PI-initiated N-of-1 trials for Cree Leukoencephalopathy using investigatory product from Calico. G.B. has received an unrestricted educational grant from Takeda (2021\u20132022). G.B. serves on the Scientific Advisory Board of the Pelizaeus-Merzbacher Foundation, the Yaya Foundation Scientific and Clinical Advisory Council and the Medical and Scientific Advisory Board of the United Leukodystrophy Foundation. G.B. is a member of the Vanishing White Matter Consortium, H-ABC Clinical Advisory Board, MLC Clinical Expert Consortium and the Chair of the POLR3-related (4H) Leukodystrophy Consortium. G.B. is on the editorial boards of Neurology Genetics, Frontiers in Neurology \u2013 Neurogenetics, and Journal of Medical Genetics.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}]}}