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L.S.G. has received consultancy fees from AbbVie, Eli Lilly, Gilead, GSK, Janssen, Novartis, Pfizer and UCB, and research grants from Pfizer. T.R. has received research funding from Pfizer. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}