{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:58:59Z","timestamp":1793271539991,"version":"4.5.0"},"reference-count":174,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Rheumatol"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1038\/s41584-022-00874-5","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T12:02:49Z","timestamp":1672747369000},"page":"153-165","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Phenotypic heterogeneity in psoriatic arthritis: towards tissue pathology-based therapy"],"prefix":"10.1038","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6008-503X","authenticated-orcid":false,"given":"Aurelie","family":"Najm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-5941","authenticated-orcid":false,"given":"Carl S.","family":"Goodyear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4449-8501","authenticated-orcid":false,"given":"Iain B.","family":"McInnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1802-7311","authenticated-orcid":false,"given":"Stefan","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"874_CR1","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.semarthrit.2018.01.003","volume":"48","author":"L Scotti","year":"2018","unstructured":"Scotti, L., Franchi, M., Marchesoni, A. & Corrao, G. Prevalence and incidence of psoriatic arthritis: a systematic review and meta-analysis. Semin. Arthritis Rheum. 48, 28\u201334 (2018).","journal-title":"Semin. Arthritis Rheum."},{"key":"874_CR2","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jaad.2018.06.027","volume":"80","author":"F Alinaghi","year":"2019","unstructured":"Alinaghi, F. et al. Prevalence of psoriatic arthritis in patients with psoriasis: a systematic review and meta-analysis of observational and clinical studies. J. Am. Acad. Dermatol. 80, 251\u2013265.e19 (2019).","journal-title":"J. Am. Acad. Dermatol."},{"key":"874_CR3","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1056\/NEJMra1505557","volume":"376","author":"CT Ritchlin","year":"2017","unstructured":"Ritchlin, C. T., Colbert, R. A. & Gladman, D. D. Psoriatic arthritis. N. Engl. J. Med. 376, 2095\u20132096 (2017).","journal-title":"N. Engl. J. Med."},{"key":"874_CR4","doi-asserted-by":"publisher","first-page":"839","DOI":"10.3899\/jrheum.190677","volume":"47","author":"M Zardin-Moraes","year":"2020","unstructured":"Zardin-Moraes, M. et al. Prevalence of psoriatic arthritis patients achieving minimal disease activity in real-world studies and randomized clinical trials: systematic review with metaanalysis. J. Rheumatol. 47, 839\u2013846 (2020).","journal-title":"J. Rheumatol."},{"key":"874_CR5","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1136\/annrheumdis-2021-220263","volume":"80","author":"JS Smolen","year":"2021","unstructured":"Smolen, J. S. et al. Effectiveness of IL-12\/23 inhibition (ustekinumab) versus tumour necrosis factor inhibition in psoriatic arthritis: observational PsABio study results. Ann. Rheum. Dis. 80, 1419\u20131428 (2021).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR6","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1016\/S0140-6736(18)30830-4","volume":"391","author":"DJ Veale","year":"2018","unstructured":"Veale, D. J. & Fearon, U. The pathogenesis of psoriatic arthritis. Lancet 391, 2273\u20132284 (2018).","journal-title":"Lancet"},{"key":"874_CR7","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/S0140-6736(21)00184-7","volume":"397","author":"K Ghoreschi","year":"2021","unstructured":"Ghoreschi, K., Balato, A., Enerb\u00e4ck, C. & Sabat, R. Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. Lancet 397, 754\u2013766 (2021).","journal-title":"Lancet"},{"key":"874_CR8","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1136\/annrheumdis-2018-213654","volume":"78","author":"S Siebert","year":"2019","unstructured":"Siebert, S., Millar, N. L. & McInnes, I. B. Why did IL-23p19 inhibition fail in AS: a tale of tissues, trials or translation? Ann. Rheum. Dis. 78, 1015\u20131018 (2019).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR9","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/s41584-020-00507-9","volume":"16","author":"DR Jadon","year":"2020","unstructured":"Jadon, D. R., Stober, C., Pennington, S. R. & FitzGerald, O. Applying precision medicine to unmet clinical needs in psoriatic disease. Nat. Rev. Rheumatol. 16, 609\u2013627 (2020).","journal-title":"Nat. Rev. Rheumatol."},{"key":"874_CR10","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41584-019-0175-0","volume":"15","author":"JU Scher","year":"2019","unstructured":"Scher, J. U., Ogdie, A., Merola, J. F. & Ritchlin, C. Preventing psoriatic arthritis: focusing on patients with psoriasis at increased risk of transition. Nat. Rev. Rheumatol. 15, 153\u2013166 (2019).","journal-title":"Nat. Rev. Rheumatol."},{"key":"874_CR11","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/j.humimm.2013.07.014","volume":"74","author":"V Chandran","year":"2013","unstructured":"Chandran, V. et al. Human leukocyte antigen alleles and susceptibility to psoriatic arthritis. Hum. Immunol. 74, 1333\u20131338 (2013).","journal-title":"Hum. Immunol."},{"key":"874_CR12","doi-asserted-by":"publisher","first-page":"596086","DOI":"10.3389\/fimmu.2020.596086","volume":"11","author":"M Vecellio","year":"2020","unstructured":"Vecellio, M. et al. The IL-17\/IL-23 axis and its genetic contribution to psoriatic arthritis. Front. Immunol. 11, 596086 (2020).","journal-title":"Front. Immunol."},{"key":"874_CR13","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/nrrheum.2011.169","volume":"7","author":"DD O\u2019Rielly","year":"2011","unstructured":"O\u2019Rielly, D. D. & Rahman, P. Genetics of susceptibility and treatment response in psoriatic arthritis. Nat. Rev. Rheumatol. 7, 718\u2013732 (2011).","journal-title":"Nat. Rev. Rheumatol."},{"key":"874_CR14","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.berh.2014.10.010","volume":"28","author":"DD O\u2019Rielly","year":"2014","unstructured":"O\u2019Rielly, D. D. & Rahman, P. Genetics of psoriatic arthritis. Best Pract. Res. Clin. Rheumatol. 28, 673\u2013685 (2014).","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"874_CR15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/BOR.0000000000000136","volume":"27","author":"L Eder","year":"2015","unstructured":"Eder, L., Chandran, V. & Gladman, D. D. What have we learned about genetic susceptibility in psoriasis and psoriatic arthritis? Curr. Opin. Rheumatol. 27, 91\u201398 (2015).","journal-title":"Curr. Opin. Rheumatol."},{"key":"874_CR16","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3899\/jrheum.111242","volume":"39","author":"P Rahman","year":"2012","unstructured":"Rahman, P. & Elder, J. T. Genetics of psoriasis and psoriatic arthritis: a report from the GRAPPA 2010 annual meeting. J. Rheumatol. 39, 431\u2013433 (2012).","journal-title":"J. Rheumatol."},{"key":"874_CR17","doi-asserted-by":"publisher","first-page":"954","DOI":"10.3389\/fimmu.2018.00954","volume":"9","author":"JC Prinz","year":"2018","unstructured":"Prinz, J. C. Human leukocyte antigen-class I alleles and the autoreactive T cell response in psoriasis pathogenesis. Front. Immunol. 9, 954 (2018).","journal-title":"Front. Immunol."},{"key":"874_CR18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s13075-015-0640-3","volume":"17","author":"O FitzGerald","year":"2015","unstructured":"FitzGerald, O., Haroon, M., Giles, J. T. & Winchester, R. Concepts of pathogenesis in psoriatic arthritis: genotype determines clinical phenotype. Arthritis Res. Ther. 17, 115 (2015).","journal-title":"Arthritis Res. Ther."},{"key":"874_CR19","doi-asserted-by":"publisher","first-page":"i4","DOI":"10.1093\/rheumatology\/kez325","volume":"59","author":"R Winchester","year":"2020","unstructured":"Winchester, R. & FitzGerald, O. The many faces of psoriatic arthritis: their genetic determinism. Rheumatology 59, i4\u2013i9 (2020).","journal-title":"Rheumatology"},{"key":"874_CR20","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1097\/BOR.0000000000000720","volume":"32","author":"R Winchester","year":"2020","unstructured":"Winchester, R. & FitzGerald, O. MHC class I associations beyond HLA-B27: the peptide binding hypothesis of psoriatic arthritis and its implications for disease pathogenesis. Curr. Opin. Rheumatol. 32, 330\u2013336 (2020).","journal-title":"Curr. Opin. Rheumatol."},{"key":"874_CR21","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1002\/art.33415","volume":"64","author":"R Winchester","year":"2012","unstructured":"Winchester, R. et al. HLA associations reveal genetic heterogeneity in psoriatic arthritis and in the psoriasis phenotype. Arthritis Rheum. 64, 1134\u20131144 (2012).","journal-title":"Arthritis Rheum."},{"key":"874_CR22","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1136\/annrheumdis-2014-205461","volume":"75","author":"M Haroon","year":"2016","unstructured":"Haroon, M., Winchester, R., Giles, J. T., Heffernan, E. & FitzGerald, O. Certain class I HLA alleles and haplotypes implicated in susceptibility play a role in determining specific features of the psoriatic arthritis phenotype. Ann. Rheum. Dis. 75, 155\u2013162 (2016).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR23","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0950-3579(94)80018-9","volume":"8","author":"CJ Eastmond","year":"1994","unstructured":"Eastmond, C. J. Psoriatic arthritis. Genetics and HLA antigens. Baillieres Clin. Rheumatol. 8, 263\u2013276 (1994).","journal-title":"Baillieres Clin. Rheumatol."},{"key":"874_CR24","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3390\/jcm6090081","volume":"6","author":"T Yago","year":"2017","unstructured":"Yago, T. et al. IL-23 and Th17 disease in inflammatory arthritis. J. Clin. Med. 6, 81 (2017).","journal-title":"J. Clin. Med."},{"key":"874_CR25","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1002\/art.42154","volume":"74","author":"M Soomro","year":"2022","unstructured":"Soomro, M. et al. Comparative genetic analysis of psoriatic arthritis and psoriasis for the discovery of genetic risk factors and risk prediction modelling. Arthritis Rheumatol. 74, 1535\u20131543\u00a0(2022).","journal-title":"Arthritis Rheumatol."},{"key":"874_CR26","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1136\/annrheumdis-2016-210592","volume":"76","author":"A Budu-Aggrey","year":"2017","unstructured":"Budu-Aggrey, A. et al. A rare coding allele in IFIH1 is protective for psoriatic arthritis. Ann. Rheum. Dis. 76, 1321\u20131324 (2017).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR27","doi-asserted-by":"publisher","first-page":"J314","DOI":"10.1016\/j.jaut.2009.12.001","volume":"34","author":"V Chandran","year":"2010","unstructured":"Chandran, V. & Raychaudhuri, S. P. Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis. J. Autoimmun. 34, J314\u2013J321 (2010).","journal-title":"J. Autoimmun."},{"key":"874_CR28","doi-asserted-by":"publisher","first-page":"9294","DOI":"10.3390\/ijms22179294","volume":"22","author":"K Dopytalska","year":"2021","unstructured":"Dopytalska, K., Ciechanowicz, P., Wiszniewski, K., Szyma\u0144ska, E. & Walecka, I. The role of epigenetic factors in psoriasis. Int. J. Mol. Sci. 22, 9294 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"874_CR29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jaut.2016.12.002","volume":"78","author":"RA Pollock","year":"2017","unstructured":"Pollock, R. A., Abji, F. & Gladman, D. D. Epigenetics of psoriatic disease: a systematic review and critical appraisal. J. Autoimmun. 78, 29\u201338 (2017).","journal-title":"J. Autoimmun."},{"key":"874_CR30","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.3899\/jrheum.190602","volume":"47","author":"SM Wade","year":"2020","unstructured":"Wade, S. M., McGarry, T., Wade, S. C., Fearon, U. & Veale, D. J. Serum microRNA signature as a diagnostic and therapeutic marker in patients with psoriatic arthritis. J. Rheumatol. 47, 1760\u20131767 (2020).","journal-title":"J. Rheumatol."},{"key":"874_CR31","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1111\/exd.13790","volume":"27","author":"MC Ovejero-Benito","year":"2018","unstructured":"Ovejero-Benito, M. C. et al. Histone modifications associated with biological drug response in moderate-to-severe psoriasis. Exp. Dermatol. 27, 1361\u20131371 (2018).","journal-title":"Exp. Dermatol."},{"key":"874_CR32","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1136\/ard.2010.147793","volume":"71","author":"L Eder","year":"2012","unstructured":"Eder, L. et al. The association between smoking and the development of psoriatic arthritis among psoriasis patients. Ann. Rheum. Dis. 71, 219\u2013224 (2012).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR33","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1136\/annrheumdis-2017-211625","volume":"77","author":"U-SDT Nguyen","year":"2018","unstructured":"Nguyen, U.-S. D. T. et al. Smoking paradox in the development of psoriatic arthritis among patients with psoriasis: a population-based study. Ann. Rheum. Dis. 77, 119\u2013123 (2018).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR34","first-page":"633","volume":"18","author":"P Goupille","year":"1991","unstructured":"Goupille, P., Soutif, D. & Valat, J. P. Psoriatic arthritis precipitated by physical trauma. J. Rheumatol. 18, 633 (1991).","journal-title":"J. Rheumatol."},{"key":"874_CR35","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1136\/ard.2007.073932","volume":"67","author":"E Pattison","year":"2008","unstructured":"Pattison, E., Harrison, B. J., Griffiths, C. E. M., Silman, A. J. & Bruce, I. N. Environmental risk factors for the development of psoriatic arthritis: results from a case-control study. Ann. Rheum. Dis. 67, 672\u2013676 (2008).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR36","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1136\/annrheumdis-2016-209334","volume":"76","author":"SM Thorarensen","year":"2017","unstructured":"Thorarensen, S. M. et al. Physical trauma recorded in primary care is associated with the onset of psoriatic arthritis among patients with psoriasis. Ann. Rheum. Dis. 76, 521\u2013525 (2017).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR37","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s10067-013-2436-7","volume":"33","author":"J Hsieh","year":"2014","unstructured":"Hsieh, J., Kadavath, S. & Efthimiou, P. Can traumatic injury trigger psoriatic arthritis? A review of the literature. Clin. Rheumatol. 33, 601\u2013608 (2014).","journal-title":"Clin. Rheumatol."},{"key":"874_CR38","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1097\/BOR.0b013e32832c6ab9","volume":"21","author":"D McGonagle","year":"2009","unstructured":"McGonagle, D., Benjamin, M. & Tan, A. L. The pathogenesis of psoriatic arthritis and associated nail disease: not autoimmune after all? Curr. Opin. Rheumatol. 21, 340\u2013347 (2009).","journal-title":"Curr. Opin. Rheumatol."},{"key":"874_CR39","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1046\/j.1365-2273.1998.00084.x","volume":"23","author":"P Wardrop","year":"1998","unstructured":"Wardrop, P., Weller, R., Marais, J. & Kavanagh, G. Tonsillitis and chronic psoriasis. Clin. Otolaryngol. Allied Sci. 23, 67\u201368 (1998).","journal-title":"Clin. Otolaryngol. Allied Sci."},{"key":"874_CR40","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1001\/archderm.1992.01680110049004","volume":"128","author":"NR Telfer","year":"1992","unstructured":"Telfer, N. R., Chalmers, R. J., Whale, K. & Colman, G. The role of streptococcal infection in the initiation of guttate psoriasis. Arch. Dermatol. 128, 39\u201342 (1992).","journal-title":"Arch. Dermatol."},{"key":"874_CR41","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac253","author":"T Thrastardottir","year":"2022","unstructured":"Thrastardottir, T. et al. Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogen. Rheumatology https:\/\/doi.org\/10.1093\/rheumatology\/keac253 (2022).","journal-title":"Rheumatology"},{"key":"874_CR42","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/art.38892","volume":"67","author":"JU Scher","year":"2015","unstructured":"Scher, J. U. et al. Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol. 67, 128\u2013139 (2015).","journal-title":"Arthritis Rheumatol."},{"key":"874_CR43","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jdermsci.2014.05.010","volume":"75","author":"N Eir\u00eds","year":"2014","unstructured":"Eir\u00eds, N. et al. Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus. J. Dermatol. Sci. 75, 167\u2013172 (2014).","journal-title":"J. Dermatol. Sci."},{"key":"874_CR44","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s40744-020-00215-6","volume":"7","author":"A Kumthekar","year":"2020","unstructured":"Kumthekar, A. & Ogdie, A. Obesity and psoriatic arthritis: a narrative review. Rheumatol. Ther. 7, 447\u2013456 (2020).","journal-title":"Rheumatol. Ther."},{"key":"874_CR45","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s40744-020-00206-7","volume":"7","author":"G Dal Bello","year":"2020","unstructured":"Dal Bello, G., Gisondi, P., Idolazzi, L. & Girolomoni, G. Psoriatic arthritis and diabetes mellitus: a narrative review. Rheumatol. Ther. 7, 271\u2013285 (2020).","journal-title":"Rheumatol. Ther."},{"key":"874_CR46","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1126\/science.7678183","volume":"259","author":"GS Hotamisligil","year":"1993","unstructured":"Hotamisligil, G. S., Shargill, N. S. & Spiegelman, B. M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259, 87\u201391 (1993).","journal-title":"Science"},{"key":"874_CR47","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.febslet.2007.11.051","volume":"582","author":"WP Cawthorn","year":"2008","unstructured":"Cawthorn, W. P. & Sethi, J. K. TNF-\u03b1 and adipocyte biology. FEBS Lett. 582, 117\u2013131 (2008).","journal-title":"FEBS Lett."},{"key":"874_CR48","doi-asserted-by":"publisher","first-page":"1956","DOI":"10.1136\/annrheumdis-2012-202325","volume":"72","author":"L Eder","year":"2013","unstructured":"Eder, L. et al. Serum adipokines in patients with psoriatic arthritis and psoriasis alone and their correlation with disease activity. Ann. Rheum. Dis. 72, 1956\u20131961 (2013).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR49","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1111\/jdv.12847","volume":"29","author":"R Candia","year":"2015","unstructured":"Candia, R. et al. Risk of non-alcoholic fatty liver disease in patients with psoriasis: a systematic review and meta-analysis. J. Eur. Acad. Dermatol. Venereol. 29, 656\u2013662 (2015).","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"874_CR50","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.jaad.2012.08.015","volume":"68","author":"AW Armstrong","year":"2013","unstructured":"Armstrong, A. W., Harskamp, C. T. & Armstrong, E. J. Psoriasis and metabolic syndrome: a systematic review and meta-analysis of observational studies. J. Am. Acad. Dermatol. 68, 654\u2013662 (2013).","journal-title":"J. Am. Acad. Dermatol."},{"key":"874_CR51","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1002\/acr.22185","volume":"66","author":"M Labitigan","year":"2014","unstructured":"Labitigan, M. et al. Higher rates and clustering of abnormal lipids, obesity, and diabetes mellitus in psoriatic arthritis compared with rheumatoid arthritis. Arthritis Care Res. 66, 600\u2013607 (2014).","journal-title":"Arthritis Care Res."},{"key":"874_CR52","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/s41584-019-0256-0","volume":"15","author":"LD Ferguson","year":"2019","unstructured":"Ferguson, L. D., Siebert, S., McInnes, I. B. & Sattar, N. Cardiometabolic comorbidities in RA and PsA: lessons learned and future directions. Nat. Rev. Rheumatol. 15, 461\u2013474 (2019).","journal-title":"Nat. Rev. Rheumatol."},{"key":"874_CR53","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/nri2622","volume":"9","author":"FO Nestle","year":"2009","unstructured":"Nestle, F. O., Di Meglio, P., Qin, J.-Z. & Nickoloff, B. J. Skin immune sentinels in health and disease. Nat. Rev. Immunol. 9, 679\u2013691 (2009).","journal-title":"Nat. Rev. Immunol."},{"key":"874_CR54","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.rdc.2015.07.006","volume":"41","author":"JL Barnas","year":"2015","unstructured":"Barnas, J. L. & Ritchlin, C. T. Etiology and pathogenesis of psoriatic arthritis. Rheum. Dis. Clin. North Am. 41, 643\u2013663 (2015).","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"874_CR55","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nri3608","volume":"14","author":"LW Peterson","year":"2014","unstructured":"Peterson, L. W. & Artis, D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat. Rev. Immunol. 14, 141\u2013153 (2014).","journal-title":"Nat. Rev. Immunol."},{"key":"874_CR56","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nrg1840","volume":"7","author":"C Crosnier","year":"2006","unstructured":"Crosnier, C., Stamataki, D. & Lewis, J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat. Rev. Genet. 7, 349\u2013359 (2006).","journal-title":"Nat. Rev. Genet."},{"key":"874_CR57","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/nri3167","volume":"12","author":"JM Blander","year":"2012","unstructured":"Blander, J. M. & Sander, L. E. Beyond pattern recognition: five immune checkpoints for scaling the microbial threat. Nat. Rev. Immunol. 12, 215\u2013225 (2012).","journal-title":"Nat. Rev. Immunol."},{"key":"874_CR58","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1038\/ncb1500","volume":"8","author":"J Lee","year":"2006","unstructured":"Lee, J. et al. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat. Cell Biol. 8, 1327\u20131336 (2006).","journal-title":"Nat. Cell Biol."},{"key":"874_CR59","doi-asserted-by":"publisher","first-page":"2841","DOI":"10.1084\/jem.20061884","volume":"203","author":"M Chieppa","year":"2006","unstructured":"Chieppa, M., Rescigno, M., Huang, A. Y. C. & Germain, R. N. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J. Exp. Med. 203, 2841\u20132852 (2006).","journal-title":"J. Exp. Med."},{"key":"874_CR60","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.chom.2012.10.003","volume":"12","author":"ED Tait Wojno","year":"2012","unstructured":"Tait Wojno, E. D. & Artis, D. Innate lymphoid cells: balancing immunity, inflammation, and tissue repair in the intestine. Cell Host Microbe 12, 445\u2013457 (2012).","journal-title":"Cell Host Microbe"},{"key":"874_CR61","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nri3349","volume":"13","author":"JA Walker","year":"2013","unstructured":"Walker, J. A., Barlow, J. L. & McKenzie, A. N. J. Innate lymphoid cells \u2014 how did we miss them? Nat. Rev. Immunol. 13, 75\u201387 (2013).","journal-title":"Nat. Rev. Immunol."},{"key":"874_CR62","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/nature08949","volume":"464","author":"S Buonocore","year":"2010","unstructured":"Buonocore, S. et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464, 1371\u20131375 (2010).","journal-title":"Nature"},{"key":"874_CR63","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature12240","volume":"498","author":"MR Hepworth","year":"2013","unstructured":"Hepworth, M. R. et al. Innate lymphoid cells regulate CD4+ T cell responses to intestinal commensal bacteria. Nature 498, 113\u2013117 (2013).","journal-title":"Nature"},{"key":"874_CR64","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1084\/jem.20101712","volume":"208","author":"A Geremia","year":"2011","unstructured":"Geremia, A. et al. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J. Exp. Med. 208, 1127\u20131133 (2011).","journal-title":"J. Exp. Med."},{"key":"874_CR65","first-page":"594","volume":"27","author":"GD Jay","year":"2000","unstructured":"Jay, G. D., Britt, D. E. & Cha, C. J. Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts. J. Rheumatol. 27, 594\u2013600 (2000).","journal-title":"J. Rheumatol."},{"key":"874_CR66","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.matbio.2014.08.008","volume":"39","author":"GD Jay","year":"2014","unstructured":"Jay, G. D. & Waller, K. A. The biology of lubricin: near frictionless joint motion. Matrix Biol. 39, 17\u201324 (2014).","journal-title":"Matrix Biol."},{"key":"874_CR67","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.3389\/fimmu.2018.01467","volume":"9","author":"J Tu","year":"2018","unstructured":"Tu, J. et al. Ontology and function of fibroblast-like and macrophage-like synoviocytes: how do they talk to each other and can they be targeted for rheumatoid arthritis therapy? Front. Immunol. 9, 1467 (2018).","journal-title":"Front. Immunol."},{"key":"874_CR68","unstructured":"ScienceDirect. Fibroblast-like synoviocyte \u2014 an overview. ScienceDirect Topics https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/fibroblast-like-synoviocyte (2016)."},{"key":"874_CR69","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","volume":"233","author":"B Bartok","year":"2010","unstructured":"Bartok, B. & Firestein, G. S. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol. Rev. 233, 233\u2013255 (2010).","journal-title":"Immunol. Rev."},{"key":"874_CR70","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/d41586-019-02340-x","volume":"572","author":"CD Buckley","year":"2019","unstructured":"Buckley, C. D. Macrophages form a protective cellular barrier in joints. Nature 572, 590\u2013592 (2019).","journal-title":"Nature"},{"key":"874_CR71","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11926-018-0751-3","volume":"20","author":"A Watad","year":"2018","unstructured":"Watad, A., Cuthbert, R. J., Amital, H. & McGonagle, D. Enthesitis: much more than focal insertion point inflammation. Curr. Rheumatol. Rep. 20, 41 (2018).","journal-title":"Curr. Rheumatol. Rep."},{"key":"874_CR72","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3899\/jrheum.120233","volume":"89","author":"D McGonagle","year":"2012","unstructured":"McGonagle, D., Aydin, S. Z. & Tan, A. L. The synovio-entheseal complex and its role in tendon and capsular associated inflammation. J. Rheumatol. Suppl. 89, 11\u201314 (2012).","journal-title":"J. Rheumatol. Suppl."},{"key":"874_CR73","doi-asserted-by":"publisher","first-page":"333","DOI":"10.32098\/mltj.03.2014.12","volume":"4","author":"J Apostolakos","year":"2014","unstructured":"Apostolakos, J. et al. The enthesis: a review of the tendon-to-bone insertion. Muscles Ligaments Tendons J. 4, 333\u2013342 (2014).","journal-title":"Muscles Ligaments Tendons J."},{"key":"874_CR74","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.semarthrit.2017.12.008","volume":"48","author":"GS Kaeley","year":"2018","unstructured":"Kaeley, G. S., Eder, L., Aydin, S. Z., Gutierrez, M. & Bakewell, C. Enthesitis: a hallmark of psoriatic arthritis. Semin. Arthritis Rheum. 48, 35\u201343 (2018).","journal-title":"Semin. Arthritis Rheum."},{"key":"874_CR75","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/j.1600-0838.2009.00906.x","volume":"19","author":"M Benjamin","year":"2009","unstructured":"Benjamin, M. & McGonagle, D. Entheses: tendon and ligament attachment sites. Scand. J. Med. Sci. Sports 19, 520\u2013527 (2009).","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"874_CR76","doi-asserted-by":"publisher","first-page":"3306","DOI":"10.1002\/art.20566","volume":"50","author":"M Benjamin","year":"2004","unstructured":"Benjamin, M. et al. The \u2018enthesis organ\u2019 concept: why enthesopathies may not present as focal insertional disorders. Arthritis Rheum. 50, 3306\u20133313 (2004).","journal-title":"Arthritis Rheum."},{"key":"874_CR77","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nrrheum.2017.188","volume":"13","author":"G Schett","year":"2017","unstructured":"Schett, G. et al. Enthesitis: from pathophysiology to treatment. Nat. Rev. Rheumatol. 13, 731\u2013741 (2017).","journal-title":"Nat. Rev. Rheumatol."},{"key":"874_CR78","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1084\/jem.180.6.2359","volume":"180","author":"JD Taurog","year":"1994","unstructured":"Taurog, J. D. et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 180, 2359\u20132364 (1994).","journal-title":"J. Exp. Med."},{"key":"874_CR79","doi-asserted-by":"publisher","first-page":"589726","DOI":"10.3389\/fmicb.2020.589726","volume":"11","author":"L Chen","year":"2020","unstructured":"Chen, L. et al. Skin and gut microbiome in psoriasis: gaining insight into the pathophysiology of it and finding novel therapeutic strategies. Front. Microbiol. 11, 589726 (2020).","journal-title":"Front. Microbiol."},{"key":"874_CR80","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.clindermatol.2019.01.011","volume":"37","author":"DJ Lewis","year":"2019","unstructured":"Lewis, D. J., Chan, W. H., Hinojosa, T., Hsu, S. & Feldman, S. R. Mechanisms of microbial pathogenesis and the role of the skin microbiome in psoriasis: a review. Clin. Dermatol. 37, 160\u2013166 (2019).","journal-title":"Clin. Dermatol."},{"key":"874_CR81","doi-asserted-by":"publisher","first-page":"942","DOI":"10.3389\/fimmu.2017.00942","volume":"8","author":"M Zhang","year":"2017","unstructured":"Zhang, M. et al. Interactions between intestinal microbiota and host immune response in inflammatory bowel disease. Front. Immunol. 8, 942 (2017).","journal-title":"Front. Immunol."},{"key":"874_CR82","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s41575-022-00581-2","volume":"19","author":"A Metwaly","year":"2022","unstructured":"Metwaly, A., Reitmeier, S. & Haller, D. Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders. Nat. Rev. Gastroenterol. Hepatol. 19, 383\u2013397 (2022).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"874_CR83","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/s41575-021-00488-4","volume":"18","author":"E Read","year":"2021","unstructured":"Read, E., Curtis, M. A. & Neves, J. F. The role of oral bacteria in inflammatory bowel disease. Nat. Rev. Gastroenterol. Hepatol. 18, 731\u2013742 (2021).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"874_CR84","doi-asserted-by":"publisher","first-page":"44","DOI":"10.12703\/P7-44","volume":"7","author":"R Boyapati","year":"2015","unstructured":"Boyapati, R., Satsangi, J. & Ho, G.-T. Pathogenesis of Crohn\u2019s disease. F1000Prime Rep. 7, 44 (2015).","journal-title":"F1000Prime Rep."},{"key":"874_CR85","doi-asserted-by":"publisher","first-page":"3998","DOI":"10.3390\/ijms22083998","volume":"22","author":"I Olejniczak-Staruch","year":"2021","unstructured":"Olejniczak-Staruch, I. et al. Alterations of the skin and gut microbiome in psoriasis and psoriatic arthritis. Int. J. Mol. Sci. 22, 3998 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"874_CR86","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.jbspin.2016.04.005","volume":"83","author":"M Breban","year":"2016","unstructured":"Breban, M. Gut microbiota and inflammatory joint diseases. Joint Bone Spine 83, 645\u2013649 (2016).","journal-title":"Joint Bone Spine"},{"key":"874_CR87","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s11926-013-0407-2","volume":"16","author":"H Eppinga","year":"2014","unstructured":"Eppinga, H., Konstantinov, S. R., Peppelenbosch, M. P. & Thio, H. B. The microbiome and psoriatic arthritis. Curr. Rheumatol. Rep. 16, 407 (2014).","journal-title":"Curr. Rheumatol. Rep."},{"key":"874_CR88","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00281-021-00844-1","volume":"43","author":"KL Yang","year":"2021","unstructured":"Yang, K. L., Lejeune, A., Chang, G., Scher, J. U. & Koralov, S. B. Microbial-derived antigens and metabolites in spondyloarthritis. Semin. Immunopathol. 43, 163\u2013172 (2021).","journal-title":"Semin. Immunopathol."},{"key":"874_CR89","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1093\/ibd\/izz046","volume":"25","author":"L Chen","year":"2019","unstructured":"Chen, L. et al. Microbiota metabolite butyrate differentially regulates Th1 and Th17 cells\u2019 differentiation and function in induction of colitis. Inflamm. Bowel Dis. 25, 1450\u20131461 (2019).","journal-title":"Inflamm. Bowel Dis."},{"key":"874_CR90","doi-asserted-by":"publisher","first-page":"iv16","DOI":"10.1093\/rheumatology\/keab385","volume":"60","author":"Z \u0141ukasik","year":"2021","unstructured":"\u0141ukasik, Z., Gracey, E., Venken, K., Ritchlin, C. & Elewaut, D. Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints. Rheumatology 60, iv16\u2013iv27 (2021).","journal-title":"Rheumatology"},{"key":"874_CR91","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/s41577-020-0352-z","volume":"20","author":"M Rumpret","year":"2020","unstructured":"Rumpret, M. et al. Functional categories of immune inhibitory receptors. Nat. Rev. Immunol. 20, 771\u2013780 (2020).","journal-title":"Nat. Rev. Immunol."},{"key":"874_CR92","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1056\/NEJMra1909094","volume":"385","author":"G Schett","year":"2021","unstructured":"Schett, G., McInnes, I. B. & Neurath, M. F. Reframing immune-mediated inflammatory diseases through signature cytokine hubs. N. Engl. J. Med. 385, 628\u2013639 (2021).","journal-title":"N. Engl. J. Med."},{"key":"874_CR93","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.autrev.2014.10.010","volume":"14","author":"JP Mackern-Oberti","year":"2015","unstructured":"Mackern-Oberti, J. P. et al. Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases. Autoimmun. Rev. 14, 127\u2013139 (2015).","journal-title":"Autoimmun. Rev."},{"key":"874_CR94","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nature06116","volume":"449","author":"R Lande","year":"2007","unstructured":"Lande, R. et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449, 564\u2013569 (2007).","journal-title":"Nature"},{"key":"874_CR95","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.3389\/fimmu.2019.01764","volume":"10","author":"MP Sch\u00f6n","year":"2019","unstructured":"Sch\u00f6n, M. P. Adaptive and innate immunity in psoriasis and other inflammatory disorders. Front. Immunol. 10, 1764 (2019).","journal-title":"Front. Immunol."},{"key":"874_CR96","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","volume":"397","author":"CEM Griffiths","year":"2021","unstructured":"Griffiths, C. E. M., Armstrong, A. W., Gudjonsson, J. E. & Barker, J. N. W. N. Psoriasis. Lancet 397, 1301\u20131315 (2021).","journal-title":"Lancet"},{"key":"874_CR97","doi-asserted-by":"publisher","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","volume":"2","author":"JE Greb","year":"2016","unstructured":"Greb, J. E. et al. Psoriasis. Nat. Rev. Dis. Primers\u00a02, 16082 (2016).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"874_CR98","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.immuni.2011.08.001","volume":"35","author":"Y Cai","year":"2011","unstructured":"Cai, Y. et al. Pivotal role of dermal IL-17-producing \u03b3\u03b4 T cells in skin inflammation. Immunity 35, 596\u2013610 (2011).","journal-title":"Immunity"},{"key":"874_CR99","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1016\/S0140-6736(17)31429-0","volume":"389","author":"P Nash","year":"2017","unstructured":"Nash, P. et al. Ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors: results from the 24-week randomised, double-blind, placebo-controlled period of the SPIRIT-P2 phase 3 trial. Lancet 389, 2317\u20132327 (2017).","journal-title":"Lancet"},{"key":"874_CR100","volume":"92","author":"LL Ten Bergen","year":"2020","unstructured":"Ten Bergen, L. L., Petrovic, A., Krogh Aarebrot, A. & Appel, S. The TNF\/IL-23\/IL-17 axis \u2014 head-to-head trials comparing different biologics in psoriasis treatment. Scand. J. Immunol. 92, e12946 (2020).","journal-title":"Scand. J. Immunol."},{"key":"874_CR101","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1002\/art.41652","volume":"73","author":"EF Leijten","year":"2021","unstructured":"Leijten, E. F. et al. Tissue-resident memory CD8+ T cells from skin differentiate psoriatic arthritis from psoriasis. Arthritis Rheumatol. 73, 1220\u20131232 (2021).","journal-title":"Arthritis Rheumatol."},{"key":"874_CR102","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.151281","volume":"7","author":"CT Prendergast","year":"2022","unstructured":"Prendergast, C. T. et al. Dissecting the molecular control of immune cell accumulation in the inflamed joint. JCI Insight 7, e151281 (2022).","journal-title":"JCI Insight"},{"key":"874_CR103","doi-asserted-by":"publisher","first-page":"R15","DOI":"10.1186\/ar1864","volume":"8","author":"SL Jongbloed","year":"2006","unstructured":"Jongbloed, S. L. et al. Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. Arthritis Res. Ther. 8, R15 (2006).","journal-title":"Arthritis Res. Ther."},{"key":"874_CR104","first-page":"374","volume":"34","author":"L Candia","year":"2007","unstructured":"Candia, L., Marquez, J., Hernandez, C., Zea, A. H. & Espinoza, L. R. Toll-like receptor-2 expression is upregulated in antigen-presenting cells from patients with psoriatic arthritis: a pathogenic role for innate immunity? J. Rheumatol. 34, 374\u2013379 (2007).","journal-title":"J. Rheumatol."},{"key":"874_CR105","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1136\/ard.2003.018085","volume":"63","author":"AY Goedkoop","year":"2004","unstructured":"Goedkoop, A. Y. et al. Early effects of tumour necrosis factor alpha blockade on skin and synovial tissue in patients with active psoriasis and psoriatic arthritis. Ann. Rheum. Dis. 63, 769\u2013773 (2004).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR106","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1136\/annrheumdis-2016-210424","volume":"76","author":"S Alivernini","year":"2017","unstructured":"Alivernini, S. et al. Synovial features of patients with rheumatoid arthritis and psoriatic arthritis in clinical and ultrasound remission differ under anti-TNF therapy: a clue to interpret different chances of relapse after clinical remission? Ann. Rheum. Dis. 76, 1228\u20131236 (2017).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR107","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1136\/ard.2005.050963","volume":"65","author":"AWR van Kuijk","year":"2006","unstructured":"van Kuijk, A. W. R., Reinders\u2010Blankert, P., Smeets, T. J. M., Dijkmans, B. A. C. & Tak, P. P. Detailed analysis of the cell infiltrate and the expression of mediators of synovial inflammation and joint destruction in the synovium of patients with psoriatic arthritis: implications for treatment. Ann. Rheum. Dis. 65, 1551\u20131557 (2006).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR108","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1136\/annrheumdis-2020-218186","volume":"80","author":"A Nerviani","year":"2021","unstructured":"Nerviani, A. et al. IL-23 skin and joint profiling in psoriatic arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors. Ann. Rheum. Dis. 80, 591\u2013597 (2021).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR109","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s13075-019-1898-7","volume":"21","author":"S Alivernini","year":"2019","unstructured":"Alivernini, S. et al. Differential synovial tissue biomarkers among psoriatic arthritis and rheumatoid factor\/anti-citrulline antibody-negative rheumatoid arthritis. Arthritis Res. Ther. 21, 116 (2019).","journal-title":"Arthritis Res. Ther."},{"key":"874_CR110","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrd4518","volume":"14","author":"HS Bartlett","year":"2015","unstructured":"Bartlett, H. S. & Million, R. P. Targeting the IL-17\u2013TH17 pathway. Nat. Rev. Drug Discov. 14, 11\u201312 (2015).","journal-title":"Nat. Rev. Drug Discov."},{"key":"874_CR111","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/imm.12142","volume":"141","author":"BW Kirkham","year":"2014","unstructured":"Kirkham, B. W., Kavanaugh, A. & Reich, K. Interleukin-17A: a unique pathway in immune-mediated diseases: psoriasis, psoriatic arthritis and rheumatoid arthritis. Immunology 141, 133\u2013142 (2014).","journal-title":"Immunology"},{"key":"874_CR112","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/ar2642","volume":"11","author":"RJ Lories","year":"2009","unstructured":"Lories, R. J., Luyten, F. P. & de Vlam, K. Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis. Arthritis Res. Ther. 11, 221 (2009).","journal-title":"Arthritis Res. Ther."},{"key":"874_CR113","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1136\/annrheumdis-2019-215356","volume":"78","author":"DG McGonagle","year":"2019","unstructured":"McGonagle, D. G., McInnes, I. B., Kirkham, B. W., Sherlock, J. & Moots, R. The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies. Ann. Rheum. Dis. 78, 1167\u20131178 (2019).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR114","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1002\/art.38376","volume":"66","author":"B Menon","year":"2014","unstructured":"Menon, B. et al. Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression. Arthritis Rheumatol. 66, 1272\u20131281 (2014).","journal-title":"Arthritis Rheumatol."},{"key":"874_CR115","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/art.41156","volume":"72","author":"KJA Steel","year":"2020","unstructured":"Steel, K. J. A. et al. Polyfunctional, proinflammatory, tissue-resident memory phenotype and function of synovial interleukin-17A+CD8+ T cells in psoriatic arthritis. Arthritis Rheumatol. 72, 435\u2013447 (2020).","journal-title":"Arthritis Rheumatol."},{"key":"874_CR116","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1136\/annrheumdis-2018-214138","volume":"78","author":"SM Wade","year":"2019","unstructured":"Wade, S. M. et al. Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis. Ann. Rheum. Dis. 78, 350\u2013354 (2019).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR117","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s13075-019-1984-x","volume":"21","author":"A Takaki-Kuwahara","year":"2019","unstructured":"Takaki-Kuwahara, A. et al. CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines. Arthritis Res. Ther. 21, 198 (2019).","journal-title":"Arthritis Res. Ther."},{"key":"874_CR118","doi-asserted-by":"publisher","first-page":"R65","DOI":"10.1186\/ar3781","volume":"14","author":"A Mitra","year":"2012","unstructured":"Mitra, A., Raychaudhuri, S. K. & Raychaudhuri, S. P. Functional role of IL-22 in psoriatic arthritis. Arthritis Res. Ther. 14, R65 (2012).","journal-title":"Arthritis Res. Ther."},{"key":"874_CR119","doi-asserted-by":"publisher","first-page":"R148","DOI":"10.1186\/ar3090","volume":"12","author":"U Fiocco","year":"2010","unstructured":"Fiocco, U. et al. Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-\u03b1 blockade in the knee joint. Arthritis Res. Ther. 12, R148 (2010).","journal-title":"Arthritis Res. Ther."},{"key":"874_CR120","doi-asserted-by":"publisher","first-page":"R136","DOI":"10.1186\/ar4317","volume":"15","author":"H Benham","year":"2013","unstructured":"Benham, H. et al. Th17 and Th22 cells in psoriatic arthritis and psoriasis. Arthritis Res. Ther. 15, R136 (2013).","journal-title":"Arthritis Res. Ther."},{"key":"874_CR121","doi-asserted-by":"publisher","first-page":"611656","DOI":"10.3389\/fimmu.2021.611656","volume":"12","author":"RH Fiechter","year":"2021","unstructured":"Fiechter, R. H. et al. IL-12p40\/IL-23p40 blockade with ustekinumab decreases the synovial inflammatory infiltrate through modulation of multiple signaling pathways including MAPK-ERK and Wnt. Front. Immunol. 12, 611656 (2021).","journal-title":"Front. Immunol."},{"key":"874_CR122","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1002\/art.40581","volume":"70","author":"LJJ van Mens","year":"2018","unstructured":"van Mens, L. J. J. et al. Brief report: interleukin-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses. Arthritis Rheumatol. 70, 1994\u20132002 (2018).","journal-title":"Arthritis Rheumatol."},{"key":"874_CR123","doi-asserted-by":"publisher","first-page":"553742","DOI":"10.3389\/fimmu.2020.553742","volume":"11","author":"N Rosine","year":"2021","unstructured":"Rosine, N. & Miceli-Richard, C. Innate cells: the alternative source of IL-17 in axial and peripheral spondyloarthritis? Front. Immunol. 11, 553742 (2021).","journal-title":"Front. Immunol."},{"key":"874_CR124","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1136\/annrheumdis-2015-208902","volume":"75","author":"E Gracey","year":"2016","unstructured":"Gracey, E. et al. IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis. Ann. Rheum. Dis. 75, 2124\u20132132 (2016).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR125","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1365-2567.2007.02638.x","volume":"122","author":"CT de Matos","year":"2007","unstructured":"de Matos, C. T. et al. Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94\/NKG2A in control of cytokine secretion. Immunology 122, 291\u2013301 (2007).","journal-title":"Immunology"},{"key":"874_CR126","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/cei.12853","volume":"186","author":"G Guggino","year":"2016","unstructured":"Guggino, G. et al. Interleukin (IL)-9\/IL-9R axis drives \u03b3\u03b4 T cells activation in psoriatic arthritis patients. Clin. Exp. Immunol. 186, 277\u2013283 (2016).","journal-title":"Clin. Exp. Immunol."},{"key":"874_CR127","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1002\/art.38995","volume":"67","author":"J Belasco","year":"2015","unstructured":"Belasco, J. et al. Comparative genomic profiling of synovium versus skin lesions in psoriatic arthritis. Arthritis Rheumatol. 67, 934\u2013944 (2015).","journal-title":"Arthritis Rheumatol."},{"key":"874_CR128","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1038\/jid.2014.261","volume":"134","author":"MBM Teunissen","year":"2014","unstructured":"Teunissen, M. B. M. et al. The IL-17A-producing CD8+ T-cell population in psoriatic lesional skin comprises mucosa-associated invariant T cells and conventional T cells. J. Invest. Dermatol. 134, 2898\u20132907 (2014).","journal-title":"J. Invest. Dermatol."},{"key":"874_CR129","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1136\/annrheumdis-2014-206323","volume":"74","author":"F Ciccia","year":"2015","unstructured":"Ciccia, F. et al. Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis. Ann. Rheum. Dis. 74, 1739\u20131747 (2015).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR130","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11926-019-0834-9","volume":"21","author":"D Mauro","year":"2019","unstructured":"Mauro, D., Macaluso, F., Fasano, S., Alessandro, R. & Ciccia, F. ILC3 in axial spondyloarthritis: the gut angle. Curr. Rheumatol. Rep. 21, 37 (2019).","journal-title":"Curr. Rheumatol. Rep."},{"key":"874_CR131","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nm.2817","volume":"18","author":"JP Sherlock","year":"2012","unstructured":"Sherlock, J. P. et al. IL-23 induces spondyloarthropathy by acting on ROR-\u03b3t+ CD3+CD4\u2212CD8\u2212 entheseal resident T cells. Nat. Med. 18, 1069\u20131076 (2012).","journal-title":"Nat. Med."},{"key":"874_CR132","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1136\/annrheumdis-2018-214944","volume":"78","author":"C Bridgewood","year":"2019","unstructured":"Bridgewood, C. et al. Identification of myeloid cells in the human enthesis as the main source of local IL-23 production. Ann. Rheum. Dis. 78, 929\u2013933 (2019).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR133","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1136\/annrheumdis-2013-204782","volume":"74","author":"IE Adamopoulos","year":"2015","unstructured":"Adamopoulos, I. E. et al. IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis. Ann. Rheum. Dis. 74, 1284\u20131292 (2015).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR134","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3390\/cells10020341","volume":"10","author":"T Russell","year":"2021","unstructured":"Russell, T. et al. IL-17A and TNF modulate normal human spinal entheseal bone and soft tissue mesenchymal stem cell osteogenesis, adipogenesis, and stromal function. Cells 10, 341 (2021).","journal-title":"Cells"},{"key":"874_CR135","doi-asserted-by":"publisher","first-page":"618581","DOI":"10.3389\/fimmu.2021.618581","volume":"12","author":"M Mandour","year":"2021","unstructured":"Mandour, M., Chen, S. & van de Sande, M. G. H. The role of the IL-23\/IL-17 axis in disease initiation in spondyloarthritis: lessons learned from animal models. Front. Immunol. 12, 618581 (2021).","journal-title":"Front. Immunol."},{"key":"874_CR136","doi-asserted-by":"publisher","first-page":"iv4","DOI":"10.1093\/rheumatology\/keab266","volume":"60","author":"A Najm","year":"2021","unstructured":"Najm, A. & McInnes, I. B. IL-23 orchestrating immune cell activation in arthritis. Rheumatology 60, iv4\u2013iv15 (2021).","journal-title":"Rheumatology"},{"key":"874_CR137","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.3389\/fimmu.2018.01550","volume":"9","author":"MN van Tok","year":"2018","unstructured":"van Tok, M. N. et al. The initiation, but not the persistence, of experimental spondyloarthritis is dependent on interleukin-23 signaling. Front. Immunol. 9, 1550 (2018).","journal-title":"Front. Immunol."},{"key":"874_CR138","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1002\/art.40770","volume":"71","author":"MN van Tok","year":"2019","unstructured":"van Tok, M. N. et al. Interleukin-17A inhibition diminishes inflammation and new bone formation in experimental spondyloarthritis. Arthritis Rheumatol. 71, 612\u2013625 (2019).","journal-title":"Arthritis Rheumatol."},{"key":"874_CR139","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1136\/annrheumdis-2019-215210","volume":"78","author":"RJ Cuthbert","year":"2019","unstructured":"Cuthbert, R. J. et al. Evidence that tissue resident human enthesis \u03b3\u03b4T-cells can produce IL-17A independently of IL-23R transcript expression. Ann. Rheum. Dis. 78, 1559\u20131565 (2019).","journal-title":"Ann. Rheum. Dis."},{"issue":"5 Suppl. 93","key":"874_CR140","first-page":"S36","volume":"33","author":"D McGonagle","year":"2015","unstructured":"McGonagle, D. & Tan, A. L. The enthesis in psoriatic arthritis. Clin. Exp. Rheumatol. 33 (Suppl. 93), S36\u2013S39 (2015).","journal-title":"Clin. Exp. Rheumatol."},{"key":"874_CR141","first-page":"369","volume":"22","author":"Yoshiga.","year":"1998","unstructured":"Yoshiga. Invariant NKT cells produce IL-17 through IL-23-dependent and -independent pathways with potential modulation of Th17 response in collagen-induced arthritis. Int. J. Mol. Med. 22, 369\u2013374\u00a0(1998).","journal-title":"Int. J. Mol. Med."},{"key":"874_CR142","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1136\/annrheumdis-2018-213328","volume":"77","author":"D Baeten","year":"2018","unstructured":"Baeten, D. et al. Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study. Ann. Rheum. Dis. 77, 1295\u20131302 (2018).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR143","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/art.40728","volume":"71","author":"A Deodhar","year":"2019","unstructured":"Deodhar, A. et al. Three multicenter, randomized, double-blind, placebo-controlled studies evaluating the efficacy and safety of ustekinumab in axial spondyloarthritis. Arthritis Rheumatol. 71, 258\u2013270 (2019).","journal-title":"Arthritis Rheumatol."},{"key":"874_CR144","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1136\/annrheumdis-2013-204741","volume":"73","author":"A Kavanaugh","year":"2014","unstructured":"Kavanaugh, A. et al. Ustekinumab, an anti-IL-12\/23 p40 monoclonal antibody, inhibits radiographic progression in patients with active psoriatic arthritis: results of an integrated analysis of radiographic data from the phase 3, multicentre, randomised, double-blind, placebo-controlled PSUMMIT-1 and PSUMMIT-2 trials. Ann. Rheum. Dis. 73, 1000\u20131006 (2014).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR145","doi-asserted-by":"publisher","first-page":"e715","DOI":"10.1016\/S2665-9913(21)00105-3","volume":"3","author":"PJ Mease","year":"2021","unstructured":"Mease, P. J. et al. Efficacy of guselkumab on axial involvement in patients with active psoriatic arthritis and sacroiliitis: a post-hoc analysis of the phase 3 DISCOVER-1 and DISCOVER-2 studies. Lancet Rheumatol. 3, e715\u2013e723 (2021).","journal-title":"Lancet Rheumatol."},{"key":"874_CR146","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1136\/annrheumdis-2021-221422","volume":"81","author":"J Braun","year":"2022","unstructured":"Braun, J. & Landew\u00e9, R. B. No efficacy of anti-IL-23 therapy for axial spondyloarthritis in randomised controlled trials but in post-hoc analyses of psoriatic arthritis-related \u2018physician-reported spondylitis\u2019? Ann. Rheum. Dis. 81, 466\u2013468 (2022).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR147","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/s41584-018-0147-9","volume":"15","author":"D McGonagle","year":"2019","unstructured":"McGonagle, D., Tan, A. L., Watad, A. & Helliwell, P. Pathophysiology, assessment and treatment of psoriatic dactylitis. Nat. Rev. Rheumatol. 15, 113\u2013122 (2019).","journal-title":"Nat. Rev. Rheumatol."},{"key":"874_CR148","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1136\/annrheumdis-2017-212681","volume":"77","author":"I Tinazzi","year":"2018","unstructured":"Tinazzi, I. et al. \u2018Deep Koebner\u2019 phenomenon of the flexor tendon-associated accessory pulleys as a novel factor in tenosynovitis and dactylitis in psoriatic arthritis. Ann. Rheum. Dis. 77, 922\u2013925 (2018).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR149","doi-asserted-by":"publisher","first-page":"E3669","DOI":"10.1073\/pnas.1405798111","volume":"111","author":"I Khmaladze","year":"2014","unstructured":"Khmaladze, I. et al. Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice. Proc. Natl Acad. Sci. USA 111, E3669\u2013E3678 (2014).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"874_CR150","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/s41584-019-0220-z","volume":"15","author":"P Cheung","year":"2019","unstructured":"Cheung, P., Khatri, P., Utz, P. J. & Kuo, A. J. Single-cell technologies \u2014 studying rheumatic diseases one cell at a time. Nat. Rev. Rheumatol. 15, 340\u2013354 (2019).","journal-title":"Nat. Rev. Rheumatol."},{"key":"874_CR151","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.celrep.2018.09.006","volume":"25","author":"JB Cheng","year":"2018","unstructured":"Cheng, J. B. et al. Transcriptional programming of normal and inflamed human epidermis at single-cell resolution. Cell Rep. 25, 871\u2013883 (2018).","journal-title":"Cell Rep."},{"key":"874_CR152","doi-asserted-by":"publisher","first-page":"10483","DOI":"10.7150\/thno.45614","volume":"10","author":"C Qie","year":"2020","unstructured":"Qie, C. et al. Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir\u2212\/\u2212 murine psoriasis. Theranostics 10, 10483\u201310497 (2020).","journal-title":"Theranostics"},{"key":"874_CR153","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202345","volume":"218","author":"S Nakamizo","year":"2021","unstructured":"Nakamizo, S. et al. Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis. J. Exp. Med. 218, e20202345 (2021).","journal-title":"J. Exp. Med."},{"key":"874_CR154","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03724-6","volume":"12","author":"Y Gao","year":"2021","unstructured":"Gao, Y. et al. Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells. Cell Death Dis. 12, 450 (2021).","journal-title":"Cell Death Dis."},{"key":"874_CR155","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1016\/j.jaci.2020.11.028","volume":"147","author":"J Liu","year":"2021","unstructured":"Liu, J. et al. Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8+ T cells in autoimmunity and cancer. J. Allergy Clin. Immunol. 147, 2370\u20132380 (2021).","journal-title":"J. Allergy Clin. Immunol."},{"key":"874_CR156","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18513-6","volume":"11","author":"F Penkava","year":"2020","unstructured":"Penkava, F. et al. Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis. Nat. Commun. 11, 4767 (2020).","journal-title":"Nat. Commun."},{"key":"874_CR157","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1093\/rheumatology\/key069","volume":"58","author":"I Miyagawa","year":"2019","unstructured":"Miyagawa, I. et al. Precision medicine using different biological DMARDs based on characteristic phenotypes of peripheral T helper cells in psoriatic arthritis. Rheumatology 58, 336\u2013344 (2019).","journal-title":"Rheumatology"},{"key":"874_CR158","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1038\/s42003-021-02931-3","volume":"4","author":"D Simone","year":"2021","unstructured":"Simone, D. et al. Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates. Commun. Biol. 4, 1395 (2021).","journal-title":"Commun. Biol."},{"key":"874_CR159","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1136\/annrheumdis-2021-220280","volume":"80","author":"N Yager","year":"2021","unstructured":"Yager, N. et al. Ex vivo mass cytometry analysis reveals a profound myeloid proinflammatory signature in psoriatic arthritis synovial fluid. Ann. Rheum. Dis. 80, 1559\u20131567 (2021).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR160","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221761","author":"A Floudas","year":"2022","unstructured":"Floudas, A. et al. Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis. Ann. Rheum. Dis. https:\/\/doi.org\/10.1136\/annrheumdis-2021-221761 (2022).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR161","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1136\/annrheumdis-2021-220256","volume":"80","author":"M Akbar","year":"2021","unstructured":"Akbar, M. et al. Single cell and spatial transcriptomics in human tendon disease indicate dysregulated immune homeostasis. Ann. Rheum. Dis. 80, 1494\u20131497 (2021).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR162","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nri2940","volume":"11","author":"P Matzinger","year":"2011","unstructured":"Matzinger, P. & Kamala, T. Tissue-based class control: the other side of tolerance. Nat. Rev. Immunol. 11, 221\u2013230 (2011).","journal-title":"Nat. Rev. Immunol."},{"key":"874_CR163","doi-asserted-by":"publisher","first-page":"711823","DOI":"10.3389\/fmed.2021.711823","volume":"8","author":"JW Bolt","year":"2021","unstructured":"Bolt, J. W., van Ansenwoude, C. M. J., Hammoura, I., van de Sande, M. G. & van Baarsen, L. G. M. Translational research studies unraveling the origins of psoriatic arthritis: moving beyond skin and joints. Front. Med. 8, 711823 (2021).","journal-title":"Front. Med."},{"key":"874_CR164","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-001845","volume":"7","author":"E Pournara","year":"2021","unstructured":"Pournara, E. et al. Clinically relevant patient clusters identified by machine learning from the clinical development programme of secukinumab in psoriatic arthritis. RMD Open\u00a07, e001845 (2021).","journal-title":"RMD Open"},{"key":"874_CR165","doi-asserted-by":"publisher","first-page":"150","DOI":"10.2340\/00015555-1440","volume":"93","author":"A Gedebjerg","year":"2013","unstructured":"Gedebjerg, A., Johansen, C., Kragballe, K. & Iversen, L. IL-20, IL-21 and p40: potential biomarkers of treatment response for ustekinumab. Acta Derm. Venereol. 93, 150\u2013155 (2013).","journal-title":"Acta Derm. Venereol."},{"key":"874_CR166","doi-asserted-by":"publisher","first-page":"R7","DOI":"10.1186\/ar3228","volume":"13","author":"EK Pontifex","year":"2011","unstructured":"Pontifex, E. K. et al. Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy \u2014 a single centre, open-label study. Arthritis Res. Ther. 13, R7 (2011).","journal-title":"Arthritis Res. Ther."},{"key":"874_CR167","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1002\/prca.201500051","volume":"10","author":"ES Collins","year":"2016","unstructured":"Collins, E. S. et al. A clinically based protein discovery strategy to identify potential biomarkers of response to anti-TNF-\u03b1 treatment of psoriatic arthritis. Prot. Clin. Appl. 10, 645\u2013662 (2016).","journal-title":"Prot. Clin. Appl."},{"key":"874_CR168","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1136\/annrheumdis-2014-205417","volume":"75","author":"OS Ademowo","year":"2016","unstructured":"Ademowo, O. S. et al. Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis. Ann. Rheum. Dis. 75, 234\u2013241 (2016).","journal-title":"Ann. Rheum. Dis."},{"key":"874_CR169","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.molmed.2020.04.004","volume":"26","author":"D Cibrian","year":"2020","unstructured":"Cibrian, D., de la Fuente, H. & S\u00e1nchez-Madrid, F. Metabolic pathways that control skin homeostasis and inflammation. Trends Mol. Med. 26, 975\u2013986 (2020).","journal-title":"Trends Mol. Med."},{"key":"874_CR170","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2310970","volume":"2018","author":"S Cohen","year":"2018","unstructured":"Cohen, S., Barer, F., Itzhak, I., Silverman, M. H. & Fishman, P. Inhibition of IL-17 and IL-23 in human keratinocytes by the A3 adenosine receptor agonist piclidenoson. J. Immunol. Res. 2018, e2310970 (2018).","journal-title":"J. Immunol. Res."},{"key":"874_CR171","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1468-3083.2011.04078.x","volume":"26","author":"M David","year":"2012","unstructured":"David, M. et al. Treatment of plaque-type psoriasis with oral CF101: data from an exploratory randomized phase 2 clinical trial. J. Eur. Acad. Dermatol. Venereol. 26, 361\u2013367 (2012).","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"874_CR172","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.molimm.2013.11.015","volume":"59","author":"K Schaper","year":"2014","unstructured":"Schaper, K., Kietzmann, M. & B\u00e4umer, W. Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells. Mol. Immunol. 59, 10\u201318 (2014).","journal-title":"Mol. Immunol."},{"key":"874_CR173","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/acr2.11056","volume":"1","author":"\u015eB T\u00f6n\u00fck","year":"2019","unstructured":"T\u00f6n\u00fck, \u015e. B. & Yorganc\u0131o\u011flu, Z. R. Biomechanical factors in psoriatic disease: defective repair exertion as a potential cause. hypothesis presentation and literature review. ACR Open. Rheumatol. 1, 452\u2013461 (2019).","journal-title":"ACR Open. Rheumatol."},{"issue":"Suppl. 1","key":"874_CR174","first-page":"52","volume":"49","author":"LC Coates","year":"2022","unstructured":"Coates, L. C. et al. GRAPPA treatment recommendations: 2021 update. J. Rheumatol. 49 (Suppl. 1), 52\u201354\u00a0(2022).","journal-title":"J. Rheumatol."}],"container-title":["Nature Reviews Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41584-022-00874-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41584-022-00874-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41584-022-00874-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T14:07:01Z","timestamp":1677247621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41584-022-00874-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,3]]},"references-count":174,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["874"],"URL":"https:\/\/doi.org\/10.1038\/s41584-022-00874-5","relation":{},"ISSN":["1759-4790","1759-4804"],"issn-type":[{"value":"1759-4790","type":"print"},{"value":"1759-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,3]]},"assertion":[{"value":"6 November 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}