{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:56:20Z","timestamp":1792803380527,"version":"4.5.0"},"reference-count":124,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Rheumatol"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1038\/s41584-024-01107-7","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T12:01:48Z","timestamp":1712750508000},"page":"258-271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis"],"prefix":"10.1038","volume":"20","author":[{"given":"Margaret H.","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Fuhlbrigge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-3702","authenticated-orcid":false,"given":"Peter A.","family":"Nigrovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"1107_CR1","doi-asserted-by":"publisher","unstructured":"Chang, M. H. & Nigrovic, P. A. Antibody-dependent and -independent mechanisms of inflammatory arthritis. JCI Insight 4, https:\/\/doi.org\/10.1172\/jci.insight.125278 (2019).","DOI":"10.1172\/jci.insight.125278"},{"key":"1107_CR2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1056\/NEJMra2103726","volume":"388","author":"EM Gravallese","year":"2023","unstructured":"Gravallese, E. M. & Firestein, G. S. Rheumatoid arthritis \u2014 common origins, divergent mechanisms. N. Engl. J. Med. 388, 529\u2013542 (2023).","journal-title":"N. Engl. J. Med."},{"key":"1107_CR3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/art.1780310215","volume":"31","author":"WN Roberts","year":"1988","unstructured":"Roberts, W. N., Daltroy, L. H. & Anderson, R. J. Stability of normal joint findings in persistent classic rheumatoid arthritis. Arthritis Rheum. 31, 267\u2013271 (1988).","journal-title":"Arthritis Rheum."},{"key":"1107_CR4","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/art.42240","volume":"74","author":"MH Chang","year":"2022","unstructured":"Chang, M. H. et al. Joint-specific memory and sustained risk for new joint accumulation in autoimmune arthritis. Arthritis Rheumatol. 74, 1851\u20131858 (2022).","journal-title":"Arthritis Rheumatol."},{"key":"1107_CR5","doi-asserted-by":"crossref","first-page":"109902","DOI":"10.1016\/j.celrep.2021.109902","volume":"37","author":"MH Chang","year":"2021","unstructured":"Chang, M. H. et al. Arthritis flares mediated by tissue-resident memory T cells in the joint. Cell Rep. 37, 109902 (2021).","journal-title":"Cell Rep."},{"key":"1107_CR6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1136\/annrheumdis-2021-220882","volume":"81","author":"SL Heckert","year":"2022","unstructured":"Heckert, S. L. et al. Joint inflammation tends to recur in the same joints during the rheumatoid arthritis disease course. Ann. Rheum. Dis. 81, 169\u2013174 (2022).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR7","volume":"9","author":"SL Heckert","year":"2023","unstructured":"Heckert, S. L. et al. Patterns of clinical joint inflammation in juvenile idiopathic arthritis. RMD Open 9, e002941 (2023).","journal-title":"RMD Open"},{"key":"1107_CR8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/imr.12650","volume":"283","author":"T Gebhardt","year":"2018","unstructured":"Gebhardt, T., Palendira, U., Tscharke, D. C. & Bedoui, S. Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance. Immunol. Rev. 283, 54\u201376 (2018).","journal-title":"Immunol. Rev."},{"key":"1107_CR9","doi-asserted-by":"crossref","first-page":"eaas9673","DOI":"10.1126\/sciimmunol.aas9673","volume":"4","author":"PA Szabo","year":"2019","unstructured":"Szabo, P. A., Miron, M. & Farber, D. L. Location, location, location: tissue resident memory T cells in mice and humans. Sci. Immunol. 4, eaas9673 (2019).","journal-title":"Sci. Immunol."},{"key":"1107_CR10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jid.2017.08.038","volume":"138","author":"K Boniface","year":"2018","unstructured":"Boniface, K. et al. Vitiligo skin is imprinted with resident memory CD8 T cells expressing CXCR3. J. Invest. Dermatol. 138, 355\u2013364 (2018).","journal-title":"J. Invest. Dermatol."},{"key":"1107_CR11","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jid.2018.10.032","volume":"139","author":"JM Richmond","year":"2019","unstructured":"Richmond, J. M. et al. Resident memory and recirculating memory T cells cooperate to maintain disease in a mouse model of vitiligo. J. Invest. Dermatol. 139, 769\u2013778 (2019).","journal-title":"J. Invest. Dermatol."},{"key":"1107_CR12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1084\/jem.20031482","volume":"199","author":"O Boyman","year":"2004","unstructured":"Boyman, O. et al. Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-\u03b1. J. Exp. Med. 199, 731\u2013736 (2004).","journal-title":"J. Exp. Med."},{"key":"1107_CR13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3390\/cells10020409","volume":"10","author":"AAK Samat","year":"2021","unstructured":"Samat, A. A. K., van der Geest, J., Vastert, S. J., van Loosdregt, J. & van Wijk, F. Tissue-resident memory T cells in chronic inflammation-local cells with systemic effects? Cells 10, 409 (2021).","journal-title":"Cells"},{"key":"1107_CR14","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41590-020-0607-7","volume":"21","author":"R Fonseca","year":"2020","unstructured":"Fonseca, R. et al. Developmental plasticity allows outside-in immune responses by resident memory T cells. Nat. Immunol. 21, 412\u2013421 (2020).","journal-title":"Nat. Immunol."},{"key":"1107_CR15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41586-021-03351-3","volume":"592","author":"S Wijeyesinghe","year":"2021","unstructured":"Wijeyesinghe, S. et al. Expansible residence decentralizes immune homeostasis. Nature 592, 457\u2013462 (2021).","journal-title":"Nature"},{"key":"1107_CR16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nri.2015.3","volume":"16","author":"SN Mueller","year":"2016","unstructured":"Mueller, S. N. & Mackay, L. K. Tissue-resident memory T cells: local specialists in immune defence. Nat. Rev. Immunol. 16, 79\u201389 (2016).","journal-title":"Nat. Rev. Immunol."},{"key":"1107_CR17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.13218","volume":"316","author":"M Heeg","year":"2023","unstructured":"Heeg, M. & Goldrath, A. W. Insights into phenotypic and functional CD8+ TRM heterogeneity. Immunol. Rev. 316, 8\u201322 (2023).","journal-title":"Immunol. Rev."},{"key":"1107_CR18","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.celrep.2017.08.078","volume":"20","author":"BV Kumar","year":"2017","unstructured":"Kumar, B. V. et al. Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites. Cell Rep. 20, 2921\u20132934 (2017).","journal-title":"Cell Rep."},{"key":"1107_CR19","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/s41590-022-01229-8","volume":"23","author":"JT Crowl","year":"2022","unstructured":"Crowl, J. T. et al. Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments. Nat. Immunol. 23, 1121\u20131131 (2022).","journal-title":"Nat. Immunol."},{"key":"1107_CR20","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1126\/science.aad2035","volume":"352","author":"LK Mackay","year":"2016","unstructured":"Mackay, L. K. et al. Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Science 352, 459\u2013463 (2016).","journal-title":"Science"},{"key":"1107_CR21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41590-022-01395-9","volume":"24","author":"MML Poon","year":"2023","unstructured":"Poon, M. M. L. et al. Tissue adaptation and clonal segregation of human memory T cells in barrier sites. Nat. Immunol. 24, 309\u2013319 (2023).","journal-title":"Nat. Immunol."},{"key":"1107_CR22","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/s41590-021-01004-1","volume":"22","author":"SN Christo","year":"2021","unstructured":"Christo, S. N. et al. Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity. Nat. Immunol. 22, 1140\u20131151 (2021).","journal-title":"Nat. Immunol."},{"key":"1107_CR23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.immuni.2022.12.007","volume":"56","author":"YH Lin","year":"2023","unstructured":"Lin, Y. H. et al. Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes. Immunity 56, 207\u2013223.e8 (2023).","journal-title":"Immunity"},{"key":"1107_CR24","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.4049\/jimmunol.1502337","volume":"196","author":"JM Schenkel","year":"2016","unstructured":"Schenkel, J. M. et al. IL-15-independent maintenance of tissue-resident and boosted effector memory CD8 T cells. J. Immunol. 196, 3920\u20133926 (2016).","journal-title":"J. Immunol."},{"key":"1107_CR25","doi-asserted-by":"crossref","first-page":"108661","DOI":"10.1016\/j.celrep.2020.108661","volume":"34","author":"MEB FitzPatrick","year":"2021","unstructured":"FitzPatrick, M. E. B. et al. Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets. Cell Rep. 34, 108661 (2021).","journal-title":"Cell Rep."},{"key":"1107_CR26","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.immuni.2020.04.007","volume":"52","author":"JJ Milner","year":"2020","unstructured":"Milner, J. J. et al. Heterogenous populations of tissue-resident CD8+ T cells are generated in response to infection and malignancy. Immunity 52, 808\u2013824.e7 (2020).","journal-title":"Immunity"},{"key":"1107_CR27","doi-asserted-by":"publisher","unstructured":"Frizzell, H. et al. Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes. Sci. Immunol. 5, https:\/\/doi.org\/10.1126\/sciimmunol.aay9283 (2020).","DOI":"10.1126\/sciimmunol.aay9283"},{"key":"1107_CR28","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nature21379","volume":"543","author":"Y Pan","year":"2017","unstructured":"Pan, Y. et al. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature 543, 252\u2013256 (2017).","journal-title":"Nature"},{"key":"1107_CR29","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.3389\/fimmu.2017.01949","volume":"8","author":"D Howie","year":"2017","unstructured":"Howie, D., Ten Bokum, A., Necula, A. S., Cobbold, S. P. & Waldmann, H. The role of lipid metabolism in T lymphocyte differentiation and survival. Front. Immunol. 8, 1949 (2017).","journal-title":"Front. Immunol."},{"key":"1107_CR30","doi-asserted-by":"publisher","unstructured":"Jin, R. et al. Role of FABP5 in T cell lipid metabolism and function in the tumor microenvironment. Cancers 15, https:\/\/doi.org\/10.3390\/cancers15030657 (2023).","DOI":"10.3390\/cancers15030657"},{"key":"1107_CR31","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.cell.2015.03.031","volume":"161","author":"EM Steinert","year":"2015","unstructured":"Steinert, E. M. et al. Quantifying memory CD8 T cells reveals regionalization of immunosurveillance. Cell 161, 737\u2013749 (2015).","journal-title":"Cell"},{"key":"1107_CR32","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1140","volume":"9","author":"J Jung","year":"2020","unstructured":"Jung, J. et al. Synovial fluid CD69+CD8+ T cells with tissue-resident phenotype mediate perforin-dependent citrullination in rheumatoid arthritis. Clin. Transl. Immunol. 9, e1140 (2020).","journal-title":"Clin. Transl. Immunol."},{"key":"1107_CR33","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2019-216456","volume":"80","author":"G Guggino","year":"2021","unstructured":"Guggino, G., Rizzo, A., Mauro, D., Macaluso, F. & Ciccia, F. Gut-derived CD8+ tissue-resident memory T cells are expanded in the peripheral blood and synovia of SpA patients. Ann. Rheum. Dis. 80, e174 (2021).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1084\/jem.191.2.313","volume":"191","author":"R Horai","year":"2000","unstructured":"Horai, R. et al. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J. Exp. Med. 191, 313\u2013320 (2000).","journal-title":"J. Exp. Med."},{"key":"1107_CR35","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","volume":"20","author":"F Zhang","year":"2019","unstructured":"Zhang, F. et al. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat. Immunol. 20, 928\u2013942 (2019).","journal-title":"Nat. Immunol."},{"key":"1107_CR36","doi-asserted-by":"crossref","first-page":"eabo0686","DOI":"10.1126\/scitranslmed.abo0686","volume":"14","author":"AH Jonsson","year":"2022","unstructured":"Jonsson, A. H. et al. Granzyme K+ CD8 T cells form a core population in inflamed human tissue. Sci. Transl. Med. 14, eabo0686 (2022).","journal-title":"Sci. Transl. Med."},{"key":"1107_CR37","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1172\/JCI96107","volume":"128","author":"A Petrelli","year":"2018","unstructured":"Petrelli, A. et al. PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation. J. Clin. Invest. 128, 4669\u20134681 (2018).","journal-title":"J. Clin. Invest."},{"key":"1107_CR38","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250162","volume":"53","author":"A Vanni","year":"2023","unstructured":"Vanni, A. et al. Clonally expanded PD-1-expressing T cells are enriched in synovial fluid of juvenile idiopathic arthritis patients. Eur. J. Immunol. 53, e2250162 (2023).","journal-title":"Eur. J. Immunol."},{"key":"1107_CR39","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/eji.202048797","volume":"51","author":"P Maschmeyer","year":"2021","unstructured":"Maschmeyer, P. et al. Antigen-driven PD-1+ TOX+ BHLHE40+ and PD-1+ TOX+ EOMES+ T lymphocytes regulate juvenile idiopathic arthritis in situ. Eur. J. Immunol. 51, 915\u2013929 (2021).","journal-title":"Eur. J. Immunol."},{"key":"1107_CR40","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/art.41156","volume":"72","author":"KJA Steel","year":"2020","unstructured":"Steel, K. J. A. et al. Polyfunctional, proinflammatory, tissue-resident memory phenotype and function of synovial interleukin-17A+CD8+ T cells in psoriatic arthritis. Arthritis Rheumatol. 72, 435\u2013447 (2020).","journal-title":"Arthritis Rheumatol."},{"key":"1107_CR41","doi-asserted-by":"crossref","first-page":"112514","DOI":"10.1016\/j.celrep.2023.112514","volume":"42","author":"GAM Povoleri","year":"2023","unstructured":"Povoleri, G. A. M. et al. Psoriatic and rheumatoid arthritis joints differ in the composition of CD8+ tissue-resident memory T cell subsets. Cell Rep. 42, 112514 (2023).","journal-title":"Cell Rep."},{"key":"1107_CR42","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18513-6","volume":"11","author":"F Penkava","year":"2020","unstructured":"Penkava, F. et al. Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis. Nat. Commun. 11, 4767 (2020).","journal-title":"Nat. Commun."},{"key":"1107_CR43","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1136\/annrheumdis-2019-215349","volume":"78","author":"Z Qaiyum","year":"2019","unstructured":"Qaiyum, Z., Gracey, E., Yao, Y. & Inman, R. D. Integrin and transcriptomic profiles identify a distinctive synovial CD8+ T cell subpopulation in spondyloarthritis. Ann. Rheum. Dis. 78, 1566\u20131575 (2019).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41423-019-0359-1","volume":"17","author":"SC Sasson","year":"2020","unstructured":"Sasson, S. C., Gordon, C. L., Christo, S. N., Klenerman, P. & Mackay, L. K. Local heroes or villains: tissue-resident memory T cells in human health and disease. Cell Mol. Immunol. 17, 113\u2013122 (2020).","journal-title":"Cell Mol. Immunol."},{"key":"1107_CR45","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41590-019-0398-x","volume":"20","author":"A Arazi","year":"2019","unstructured":"Arazi, A. et al. The immune cell landscape in kidneys of patients with lupus nephritis. Nat. Immunol. 20, 902\u2013914 (2019).","journal-title":"Nat. Immunol."},{"key":"1107_CR46","doi-asserted-by":"crossref","first-page":"102424","DOI":"10.1016\/j.jaut.2020.102424","volume":"109","author":"M Zhou","year":"2020","unstructured":"Zhou, M. et al. JAK\/STAT signaling controls the fate of CD8+CD103+ tissue-resident memory T cell in lupus nephritis. J. Autoimmun. 109, 102424 (2020).","journal-title":"J. Autoimmun."},{"key":"1107_CR47","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41586-021-04044-7","volume":"599","author":"IC Boothby","year":"2021","unstructured":"Boothby, I. C. et al. Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin. Nature 599, 667\u2013672 (2021).","journal-title":"Nature"},{"key":"1107_CR48","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41584-020-0413-5","volume":"16","author":"G Nygaard","year":"2020","unstructured":"Nygaard, G. & Firestein, G. S. Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Nat. Rev. Rheumatol. 16, 316\u2013333 (2020).","journal-title":"Nat. Rev. Rheumatol."},{"key":"1107_CR49","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrrheum.2012.190","volume":"9","author":"N Bottini","year":"2013","unstructured":"Bottini, N. & Firestein, G. S. Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat. Rev. Rheumatol. 9, 24\u201333 (2013).","journal-title":"Nat. Rev. Rheumatol."},{"key":"1107_CR50","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1136\/annrheumdis-2012-201526","volume":"72","author":"K Nakano","year":"2013","unstructured":"Nakano, K., Whitaker, J. W., Boyle, D. L., Wang, W. & Firestein, G. S. DNA methylome signature in rheumatoid arthritis. Ann. Rheum. Dis. 72, 110\u2013117 (2013).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR51","doi-asserted-by":"crossref","DOI":"10.1186\/gm444","volume":"5","author":"JW Whitaker","year":"2013","unstructured":"Whitaker, J. W. et al. An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype. Genome Med. 5, 40 (2013).","journal-title":"Genome Med."},{"key":"1107_CR52","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1002\/art.39123","volume":"67","author":"R Ai","year":"2015","unstructured":"Ai, R. et al. DNA methylome signature in synoviocytes from patients with early rheumatoid arthritis compared to synoviocytes from patients with longstanding rheumatoid arthritis. Arthritis Rheumatol. 67, 1978\u20131980 (2015).","journal-title":"Arthritis Rheumatol."},{"key":"1107_CR53","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13075-017-1248-6","volume":"19","author":"T Crowley","year":"2017","unstructured":"Crowley, T. et al. Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts. Arthritis Res. Ther. 19, 35 (2017).","journal-title":"Arthritis Res. Ther."},{"key":"1107_CR54","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.immuni.2021.03.003","volume":"54","author":"J Friscic","year":"2021","unstructured":"Friscic, J. et al. The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts. Immunity 54, 1002\u20131021.e10 (2021).","journal-title":"Immunity"},{"key":"1107_CR55","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/art.42378","volume":"75","author":"J Friscic","year":"2023","unstructured":"Friscic, J. et al. Reset of inflammatory priming of joint tissue and reduction of the severity of arthritis flares by bromodomain inhibition. Arthritis Rheumatol. 75, 517\u2013532 (2023).","journal-title":"Arthritis Rheumatol."},{"key":"1107_CR56","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/nm.2050","volume":"15","author":"S Lefevre","year":"2009","unstructured":"Lefevre, S. et al. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat. Med. 15, 1414\u20131420 (2009).","journal-title":"Nat. Med."},{"key":"1107_CR57","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1056\/NEJMoa2004114","volume":"383","author":"DE Orange","year":"2020","unstructured":"Orange, D. E. et al. RNA identification of PRIME cells predicting rheumatoid arthritis flares. N. Engl. J. Med. 383, 218\u2013228 (2020).","journal-title":"N. Engl. J. Med."},{"key":"1107_CR58","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14852","volume":"8","author":"M Frank-Bertoncelj","year":"2017","unstructured":"Frank-Bertoncelj, M. et al. Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions. Nat. Commun. 8, 14852 (2017).","journal-title":"Nat. Commun."},{"key":"1107_CR59","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13075-023-03144-1","volume":"25","author":"A Ciurea","year":"2023","unstructured":"Ciurea, A. et al. Joint-level responses to tofacitinib and methotrexate: a post hoc analysis of data from ORAL Start. Arthritis Res. Ther. 25, 185 (2023).","journal-title":"Arthritis Res. Ther."},{"key":"1107_CR60","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41584-022-00790-8","volume":"18","author":"M Kurowska-Stolarska","year":"2022","unstructured":"Kurowska-Stolarska, M. & Alivernini, S. Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission. Nat. Rev. Rheumatol. 18, 384\u2013397 (2022).","journal-title":"Nat. Rev. Rheumatol."},{"key":"1107_CR61","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/s41591-020-0939-8","volume":"26","author":"S Alivernini","year":"2020","unstructured":"Alivernini, S. et al. Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nat. Med. 26, 1295\u20131306 (2020).","journal-title":"Nat. Med."},{"key":"1107_CR62","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.celrep.2014.09.032","volume":"9","author":"AV Misharin","year":"2014","unstructured":"Misharin, A. V. et al. Nonclassical Ly6C\u2212 monocytes drive the development of inflammatory arthritis in mice. Cell Rep. 9, 591\u2013604 (2014).","journal-title":"Cell Rep."},{"key":"1107_CR63","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41586-019-1471-1","volume":"572","author":"S Culemann","year":"2019","unstructured":"Culemann, S. et al. Locally renewing resident synovial macrophages provide a protective barrier for the joint. Nature 572, 670\u2013675 (2019).","journal-title":"Nature"},{"key":"1107_CR64","doi-asserted-by":"crossref","first-page":"112513","DOI":"10.1016\/j.celrep.2023.112513","volume":"42","author":"AB Montgomery","year":"2023","unstructured":"Montgomery, A. B. et al. Tissue-resident, extravascular Ly6c\u2212 monocytes are critical for inflammation in the synovium. Cell Rep. 42, 112513 (2023).","journal-title":"Cell Rep."},{"key":"1107_CR65","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1136\/annrheumdis-2016-210424","volume":"76","author":"S Alivernini","year":"2017","unstructured":"Alivernini, S. et al. Synovial features of patients with rheumatoid arthritis and psoriatic arthritis in clinical and ultrasound remission differ under anti-TNF therapy: a clue to interpret different chances of relapse after clinical remission? Ann. Rheum. Dis. 76, 1228\u20131236 (2017).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR66","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41590-019-0568-x","volume":"21","author":"H Aegerter","year":"2020","unstructured":"Aegerter, H. et al. Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection. Nat. Immunol. 21, 145\u2013157 (2020).","journal-title":"Nat. Immunol."},{"key":"1107_CR67","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41590-020-00849-2","volume":"22","author":"M Guilliams","year":"2021","unstructured":"Guilliams, M. & Svedberg, F. R. Does tissue imprinting restrict macrophage plasticity? Nat. Immunol. 22, 118\u2013127 (2021).","journal-title":"Nat. Immunol."},{"key":"1107_CR68","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1093\/rheumatology\/keac640","volume":"62","author":"MM Hanlon","year":"2023","unstructured":"Hanlon, M. M. et al. Rheumatoid arthritis macrophages are primed for inflammation and display bioenergetic and functional alterations. Rheumatology 62, 2611\u20132620 (2023).","journal-title":"Rheumatology"},{"key":"1107_CR69","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s42003-022-03050-3","volume":"5","author":"S Vickovic","year":"2022","unstructured":"Vickovic, S. et al. Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium. Commun. Biol. 5, 129 (2022).","journal-title":"Commun. Biol."},{"key":"1107_CR70","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1257530","volume":"346","author":"N Iijima","year":"2014","unstructured":"Iijima, N. & Iwasaki, A. T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells. Science 346, 93\u201398 (2014).","journal-title":"Science"},{"key":"1107_CR71","doi-asserted-by":"publisher","unstructured":"Vu, T. T., Koguchi-Yoshioka, H. & Watanabe, R. Skin-resident memory T cells: pathogenesis and implication for the treatment of psoriasis. J. Clin. Med. 10, https:\/\/doi.org\/10.3390\/jcm10173822 (2021).","DOI":"10.3390\/jcm10173822"},{"key":"1107_CR72","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/bjd.20963","volume":"186","author":"L Puig","year":"2022","unstructured":"Puig, L. et al. The biological basis of disease recurrence in psoriasis: a historical perspective and current models. Br. J. Dermatol. 186, 773\u2013781 (2022).","journal-title":"Br. J. Dermatol."},{"key":"1107_CR73","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1172\/JCI93396","volume":"127","author":"TR Matos","year":"2017","unstructured":"Matos, T. R. et al. Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing \u0251\u03b2 T cell clones. J. Clin. Invest. 127, 4031\u20134041 (2017).","journal-title":"J. Clin. Invest."},{"key":"1107_CR74","volume":"10","author":"X Li","year":"2022","unstructured":"Li, X., Jiang, M., Chen, X. & Sun, W. Etanercept alleviates psoriasis by reducing the Th17\/Treg ratio and promoting M2 polarization of macrophages. Immun. Inflamm. Dis. 10, e734 (2022).","journal-title":"Immun. Inflamm. Dis."},{"key":"1107_CR75","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.jid.2021.01.005","volume":"141","author":"H Mehta","year":"2021","unstructured":"Mehta, H. et al. Differential changes in inflammatory mononuclear phagocyte and T-cell profiles within psoriatic skin during treatment with guselkumab vs. secukinumab. J. Invest. Dermatol. 141, 1707\u20131718.e9 (2021).","journal-title":"J. Invest. Dermatol."},{"key":"1107_CR76","doi-asserted-by":"crossref","first-page":"eabq3254","DOI":"10.1126\/sciimmunol.abq3254","volume":"7","author":"SK Whitley","year":"2022","unstructured":"Whitley, S. K. et al. Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells. Sci. Immunol. 7, eabq3254 (2022).","journal-title":"Sci. Immunol."},{"key":"1107_CR77","doi-asserted-by":"crossref","first-page":"100067","DOI":"10.1016\/j.crimmu.2023.100067","volume":"4","author":"C Dong","year":"2023","unstructured":"Dong, C., Lin, L. & Du, J. Characteristics and sources of tissue-resident memory T cells in psoriasis relapse. Curr. Res. Immunol. 4, 100067 (2023).","journal-title":"Curr. Res. Immunol."},{"key":"1107_CR78","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2015-000057","volume":"1","author":"S Monti","year":"2015","unstructured":"Monti, S., Montecucco, C., Bugatti, S. & Caporali, R. Rheumatoid arthritis treatment: the earlier the better to prevent joint damage. RMD Open 1, e000057 (2015).","journal-title":"RMD Open"},{"key":"1107_CR79","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/acr.24596","volume":"73","author":"L Fraenkel","year":"2021","unstructured":"Fraenkel, L. et al. 2021 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Care Res. 73, 924\u2013939 (2021).","journal-title":"Arthritis Care Res."},{"key":"1107_CR80","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/art.11156","volume":"48","author":"M Boers","year":"2003","unstructured":"Boers, M. Understanding the window of opportunity concept in early rheumatoid arthritis. Arthritis Rheum. 48, 1771\u20131774 (2003).","journal-title":"Arthritis Rheum."},{"key":"1107_CR81","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1136\/annrheumdis-2012-203130","volume":"73","author":"JA van Nies","year":"2014","unstructured":"van Nies, J. A. et al. What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review. Ann. Rheum. Dis. 73, 861\u2013870 (2014).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR82","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2018-000870","volume":"5","author":"LE Burgers","year":"2019","unstructured":"Burgers, L. E., Raza, K. & van der Helm-van Mil, A. H. Window of opportunity in rheumatoid arthritis \u2014 definitions and supporting evidence: from old to new perspectives. RMD Open 5, e000870 (2019).","journal-title":"RMD Open"},{"key":"1107_CR83","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/art.38615","volume":"66","author":"PA Nigrovic","year":"2014","unstructured":"Nigrovic, P. A. Review: Is there a window of opportunity for treatment of systemic juvenile idiopathic arthritis? Arthritis Rheumatol. 66, 1405\u20131413 (2014).","journal-title":"Arthritis Rheumatol."},{"key":"1107_CR84","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41584-021-00590-6","volume":"17","author":"PA Nigrovic","year":"2021","unstructured":"Nigrovic, P. A. et al. Biological classification of childhood arthritis: roadmap to a molecular nomenclature. Nat. Rev. Rheumatol. 17, 257\u2013269 (2021).","journal-title":"Nat. Rev. Rheumatol."},{"key":"1107_CR85","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/art.30128","volume":"63","author":"PA Nigrovic","year":"2011","unstructured":"Nigrovic, P. A. et al. Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series. Arthritis Rheum. 63, 545\u2013555 (2011).","journal-title":"Arthritis Rheum."},{"key":"1107_CR86","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/art.40865","volume":"71","author":"NM Ter Haar","year":"2019","unstructured":"Ter Haar, N. M. et al. Treatment to target using recombinant interleukin-1 receptor antagonist as first-line monotherapy in new-onset systemic juvenile idiopathic arthritis: results from a five-year follow-up study. Arthritis Rheumatol. 71, 1163\u20131173 (2019).","journal-title":"Arthritis Rheumatol."},{"key":"1107_CR87","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/art.41612","volume":"73","author":"M Pardeo","year":"2021","unstructured":"Pardeo, M. et al. Early treatment and IL1RN single-nucleotide polymorphisms affect response to anakinra in systemic juvenile idiopathic arthritis. Arthritis Rheumatol. 73, 1053\u20131061 (2021).","journal-title":"Arthritis Rheumatol."},{"key":"1107_CR88","doi-asserted-by":"publisher","unstructured":"Henderson, L. A. et al. Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. JCI Insight 5, https:\/\/doi.org\/10.1172\/jci.insight.132508 (2020).","DOI":"10.1172\/jci.insight.132508"},{"key":"1107_CR89","doi-asserted-by":"publisher","unstructured":"Levescot, A. et al. IL-1\u03b2-driven osteoclastogenic Tregs accelerate bone erosion in arthritis. J. Clin. Invest. 131, https:\/\/doi.org\/10.1172\/JCI141008 (2021).","DOI":"10.1172\/JCI141008"},{"key":"1107_CR90","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/art.41726","volume":"73","author":"S Alivernini","year":"2021","unstructured":"Alivernini, S. et al. Inclusion of synovial tissue-derived characteristics in a nomogram for the prediction of treatment response in treatment-naive rheumatoid arthritis patients. Arthritis Rheumatol. 73, 1601\u20131613 (2021).","journal-title":"Arthritis Rheumatol."},{"key":"1107_CR91","doi-asserted-by":"publisher","unstructured":"Bergstra, S. A. et al. Earlier is better when treating rheumatoid arthritis: but can we detect a window of opportunity? RMD Open 6, https:\/\/doi.org\/10.1136\/rmdopen-2020-001242 (2020).","DOI":"10.1136\/rmdopen-2020-001242"},{"key":"1107_CR92","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1002\/art.21405","volume":"52","author":"YP Goekoop-Ruiterman","year":"2005","unstructured":"Goekoop-Ruiterman, Y. P. et al. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial. Arthritis Rheum. 52, 3381\u20133390 (2005).","journal-title":"Arthritis Rheum."},{"key":"1107_CR93","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1136\/annrheumdis-2011-200736","volume":"71","author":"K Wevers-de Boer","year":"2012","unstructured":"Wevers-de Boer, K. et al. Remission induction therapy with methotrexate and prednisone in patients with early rheumatoid and undifferentiated arthritis (the IMPROVED study). Ann. Rheum. Dis. 71, 1472\u20131477 (2012).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR94","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1007\/s10067-021-05831-3","volume":"40","author":"S Ebrahimian","year":"2021","unstructured":"Ebrahimian, S. et al. Can treating rheumatoid arthritis with disease-modifying anti-rheumatic drugs at the window of opportunity with tight control strategy lead to long-term remission and medications free remission in real-world clinical practice? A cohort study. Clin. Rheumatol. 40, 4485\u20134491 (2021).","journal-title":"Clin. Rheumatol."},{"key":"1107_CR95","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(22)01193-X","volume":"400","author":"DI Krijbolder","year":"2022","unstructured":"Krijbolder, D. I. et al. Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial. Lancet 400, 283\u2013294 (2022).","journal-title":"Lancet"},{"key":"1107_CR96","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(23)02649-1","volume":"403","author":"AP Cope","year":"2024","unstructured":"Cope, A. P. et al. Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial. Lancet 403, 838\u2013849 (2024).","journal-title":"Lancet"},{"key":"1107_CR97","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/ard.2008.096487","volume":"69","author":"D Sugiyama","year":"2010","unstructured":"Sugiyama, D. et al. Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies. Ann. Rheum. Dis. 69, 70\u201381 (2010).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR98","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/1529-0131(200001)43:1<22::AID-ANR4>3.0.CO;2-9","volume":"43","author":"JJ Anderson","year":"2000","unstructured":"Anderson, J. J., Wells, G., Verhoeven, A. C. & Felson, D. T. Factors predicting response to treatment in rheumatoid arthritis: the importance of disease duration. Arthritis Rheum. 43, 22\u201329 (2000).","journal-title":"Arthritis Rheum."},{"key":"1107_CR99","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1136\/annrheumdis-2018-214918","volume":"78","author":"D Aletaha","year":"2019","unstructured":"Aletaha, D. et al. Effect of disease duration and prior disease-modifying antirheumatic drug use on treatment outcomes in patients with rheumatoid arthritis. Ann. Rheum. Dis. 78, 1609\u20131615 (2019).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/ard-2022-223365","volume":"82","author":"A Kerschbaumer","year":"2023","unstructured":"Kerschbaumer, A. et al. Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann. Rheum. Dis. 82, 95\u2013106 (2023).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR101","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/acr.22477","volume":"67","author":"CY Chang","year":"2015","unstructured":"Chang, C. Y., Meyer, R. M. & Reiff, A. O. Impact of medication withdrawal method on flare-free survival in patients with juvenile idiopathic arthritis on combination therapy. Arthritis Care Res. 67, 658\u2013666 (2015).","journal-title":"Arthritis Care Res."},{"key":"1107_CR102","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1136\/annrheumdis-2014-207164","volume":"75","author":"J Guzman","year":"2016","unstructured":"Guzman, J. et al. The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort. Ann. Rheum. Dis. 75, 1092\u20131098 (2016).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR103","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/acr.23435","volume":"70","author":"G Simonini","year":"2018","unstructured":"Simonini, G. et al. Flares after withdrawal of biologic therapies in juvenile idiopathic arthritis: clinical and laboratory correlates of remission duration. Arthritis Care Res. 70, 1046\u20131051 (2018).","journal-title":"Arthritis Care Res."},{"key":"1107_CR104","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/art.41589","volume":"73","author":"JR Curtis","year":"2021","unstructured":"Curtis, J. R. et al. Etanercept or methotrexate withdrawal in rheumatoid arthritis patients in sustained remission. Arthritis Rheumatol. 73, 759\u2013768 (2021).","journal-title":"Arthritis Rheumatol."},{"key":"1107_CR105","first-page":"1023","volume":"79","author":"P Emery","year":"2020","unstructured":"Emery, P. et al. Adalimumab dose tapering in patients with rheumatoid arthritis who are in long-standing clinical remission: results of the phase IV PREDICTRA study. Ann. Rheum. Dis. 79, 1023\u20131030 (2020).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR106","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/acr.24994","volume":"75","author":"S Ringold","year":"2023","unstructured":"Ringold, S. et al. Disease recapture rates after medication discontinuation and flare in juvenile idiopathic arthritis: an observational study within the childhood arthritis and rheumatology research alliance registry. Arthritis Care Res. 75, 715\u2013723 (2023).","journal-title":"Arthritis Care Res."},{"key":"1107_CR107","doi-asserted-by":"publisher","unstructured":"Richmond, J. M. et al. Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo. Sci. Transl. Med. 10, https:\/\/doi.org\/10.1126\/scitranslmed.aam7710 (2018).","DOI":"10.1126\/scitranslmed.aam7710"},{"key":"1107_CR108","doi-asserted-by":"publisher","unstructured":"Hassert, M. et al. Regenerating murine CD8+ lung tissue resident memory T cells after targeted radiation exposure. J. Exp. Med. 221, https:\/\/doi.org\/10.1084\/jem.20231144 (2024).","DOI":"10.1084\/jem.20231144"},{"key":"1107_CR109","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.4049\/jimmunol.1400003","volume":"192","author":"JM Schenkel","year":"2014","unstructured":"Schenkel, J. M., Fraser, K. A. & Masopust, D. Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organs. J. Immunol. 192, 2961\u20132964 (2014).","journal-title":"J. Immunol."},{"key":"1107_CR110","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.immuni.2018.01.015","volume":"48","author":"LK Beura","year":"2018","unstructured":"Beura, L. K. et al. T cells in nonlymphoid tissues give rise to lymph-node-resident memory T cells. Immunity 48, 327\u2013338.e5 (2018).","journal-title":"Immunity"},{"key":"1107_CR111","doi-asserted-by":"publisher","unstructured":"Stolley, J. M. et al. Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection. J. Exp. Med. 217, https:\/\/doi.org\/10.1084\/jem.20192197 (2020).","DOI":"10.1084\/jem.20192197"},{"key":"1107_CR112","doi-asserted-by":"publisher","unstructured":"Klicznik, M. M. et al. Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals. Sci. Immunol. 4, https:\/\/doi.org\/10.1126\/sciimmunol.aav8995 (2019).","DOI":"10.1126\/sciimmunol.aav8995"},{"key":"1107_CR113","doi-asserted-by":"publisher","unstructured":"Mijnheer, G. et al. Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis. Elife 12, https:\/\/doi.org\/10.7554\/eLife.79016 (2023).","DOI":"10.7554\/eLife.79016"},{"key":"1107_CR114","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1136\/annrheumdis-2014-206226","volume":"75","author":"R Spreafico","year":"2016","unstructured":"Spreafico, R. et al. A circulating reservoir of pathogenic-like CD4+ T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment. Ann. Rheum. Dis. 75, 459\u2013465 (2016).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR115","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/art.41652","volume":"73","author":"EF Leijten","year":"2021","unstructured":"Leijten, E. F. et al. Tissue-resident memory CD8+ T cells from skin differentiate psoriatic arthritis from psoriasis. Arthritis Rheumatol. 73, 1220\u20131232 (2021).","journal-title":"Arthritis Rheumatol."},{"key":"1107_CR116","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1651-2227.1986.tb10324.x","volume":"75","author":"I Kunnamo","year":"1986","unstructured":"Kunnamo, I., Kallio, P., Pelkonen, P. & Viander, M. Serum-sickness-like disease is a common cause of acute arthritis in children. Acta Paediatr. Scand. 75, 964\u2013969 (1986).","journal-title":"Acta Paediatr. Scand."},{"key":"1107_CR117","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1056\/NEJM198411293112204","volume":"311","author":"TJ Lawley","year":"1984","unstructured":"Lawley, T. J. et al. A prospective clinical and immunologic analysis of patients with serum sickness. N. Engl. J. Med. 311, 1407\u20131413 (1984).","journal-title":"N. Engl. J. Med."},{"key":"1107_CR118","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/art.1780370616","volume":"37","author":"AC Steere","year":"1994","unstructured":"Steere, A. C. et al. Treatment of Lyme arthritis. Arthritis Rheum. 37, 878\u2013888 (1994).","journal-title":"Arthritis Rheum."},{"key":"1107_CR119","first-page":"585","volume":"30","author":"K Oen","year":"2003","unstructured":"Oen, K. et al. Early predictors of longterm outcome in patients with juvenile rheumatoid arthritis: subset-specific correlations. J. Rheumatol. 30, 585\u2013593 (2003).","journal-title":"J. Rheumatol."},{"key":"1107_CR120","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/annrheumdis-2014-206034","volume":"75","author":"AM Selvaag","year":"2016","unstructured":"Selvaag, A. M., Aulie, H. A., Lilleby, V. & Flato, B. Disease progression into adulthood and predictors of long-term active disease in juvenile idiopathic arthritis. Ann. Rheum. Dis. 75, 190\u2013195 (2016).","journal-title":"Ann. Rheum. Dis."},{"key":"1107_CR121","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1084\/jem.180.6.2069","volume":"180","author":"B Lengl-Janssen","year":"1994","unstructured":"Lengl-Janssen, B., Strauss, A. F., Steere, A. C. & Kamradt, T. The T helper cell response in Lyme arthritis: differential recognition of Borrelia burgdorferi outer surface protein A in patients with treatment-resistant or treatment-responsive Lyme arthritis. J. Exp. Med. 180, 2069\u20132078 (1994).","journal-title":"J. Exp. Med."},{"key":"1107_CR122","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1084\/jem.20052471","volume":"203","author":"AC Steere","year":"2006","unstructured":"Steere, A. C. et al. Antibiotic-refractory Lyme arthritis is associated with HLA\u2212DR molecules that bind a Borrelia burgdorferi peptide. J. Exp. Med. 203, 961\u2013971 (2006).","journal-title":"J. Exp. Med."},{"key":"1107_CR123","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1002\/art.38637","volume":"66","author":"EA James","year":"2014","unstructured":"James, E. A. et al. Citrulline-specific Th1 cells are increased in rheumatoid arthritis and their frequency is influenced by disease duration and therapy. Arthritis Rheumatol. 66, 1712\u20131722 (2014).","journal-title":"Arthritis Rheumatol."},{"key":"1107_CR124","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/art.21857","volume":"55","author":"PA Nigrovic","year":"2006","unstructured":"Nigrovic, P. A. & White, P. H. Care of the adult with juvenile rheumatoid arthritis. Arthritis Rheum. 55, 208\u2013216 (2006).","journal-title":"Arthritis Rheum."}],"container-title":["Nature Reviews Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41584-024-01107-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41584-024-01107-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41584-024-01107-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T09:07:27Z","timestamp":1714122447000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41584-024-01107-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,10]]},"references-count":124,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["1107"],"URL":"https:\/\/doi.org\/10.1038\/s41584-024-01107-7","relation":{},"ISSN":["1759-4790","1759-4804"],"issn-type":[{"value":"1759-4790","type":"print"},{"value":"1759-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,10]]},"assertion":[{"value":"8 March 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"P.A.N. declares consulting relationships with Alkermes, Apollo, BMS, Exo Therapeutics, Fresh Tracks Therapeutics, Merck, Novartis, Pfizer, Qiagen and Sobi; equity in Edelweiss Immune Inc.; investigator-initiated research grants from BMS and Pfizer; and authorship and editorial income from UpToDate, the American Academy of Paediatrics and <i>Arthritis & Rheumatology<\/i>. M.H.C. and R.C.F. declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}