{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:52:39Z","timestamp":1790707959213,"version":"4.1.0"},"reference-count":304,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Urol"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1038\/s41585-021-00428-6","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T11:10:36Z","timestamp":1612350636000},"page":"139-159","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Transient receptor potential channels in sensory mechanisms of the lower urinary tract"],"prefix":"10.1038","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4864-8706","authenticated-orcid":false,"given":"Matthias","family":"Vanneste","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Voets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3157-7115","authenticated-orcid":false,"given":"Wouter","family":"Everaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"428_CR1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/nrurol.2015.266","volume":"12","author":"D Griffiths","year":"2015","unstructured":"Griffiths, D. Neural control of micturition in humans: a working model. Nat. Rev. Urol. 12, 695\u2013705 (2015).","journal-title":"Nat. Rev. Urol."},{"key":"428_CR2","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/nau.20251","volume":"25","author":"P Abrams","year":"2006","unstructured":"Abrams, P. et al. Reviewing the ICS 2002 terminology report: the ongoing debate. Neurourol. Urodyn. 25, 293 (2006).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR3","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1464-410X.2005.05889.x","volume":"97","author":"DE Irwin","year":"2006","unstructured":"Irwin, D. E., Milsom, I., Kopp, Z., Abrams, P. & Cardozo, L. Impact of overactive bladder symptoms on employment, social interactions and emotional well-being in six European countries. BJU Int. 97, 96\u2013100 (2006).","journal-title":"BJU Int."},{"key":"428_CR4","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/j.1464-410X.2009.08427.x","volume":"104","author":"KS Coyne","year":"2009","unstructured":"Coyne, K. S. et al. The prevalence of lower urinary tract symptoms (LUTS) in the USA, the UK and Sweden: results from the epidemiology of LUTS (EpiLUTS) study. BJU Int. 104, 352\u2013360 (2009).","journal-title":"BJU Int."},{"key":"428_CR5","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1111\/j.1464-410X.2010.09993.x","volume":"108","author":"DE Irwin","year":"2011","unstructured":"Irwin, D. E., Kopp, Z. S., Agatep, B., Milsom, I. & Abrams, P. Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU Int. 108, 1132\u20131138 (2011).","journal-title":"BJU Int."},{"key":"428_CR6","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1464-410X.2008.08036.x","volume":"103","author":"DE Irwin","year":"2009","unstructured":"Irwin, D. E. et al. The economic impact of overactive bladder syndrome in six Western countries. BJU Int. 103, 202\u2013209 (2009).","journal-title":"BJU Int."},{"key":"428_CR7","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1016\/j.eururo.2006.09.019","volume":"50","author":"DE Irwin","year":"2006","unstructured":"Irwin, D. E. et al. Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study. Eur. Urol. 50, 1306\u20131315 (2006).","journal-title":"Eur. Urol."},{"key":"428_CR8","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/ncb2214","volume":"13","author":"K Fujiu","year":"2011","unstructured":"Fujiu, K., Nakayama, Y., Iida, H., Sokabe, M. & Yoshimura, K. Mechanoreception in motile flagella of chlamydomonas. Nat. Cell Biol. 13, 630\u2013632 (2011).","journal-title":"Nat. Cell Biol."},{"key":"428_CR9","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1105\/tpc.114.131862","volume":"27","author":"L Arias-Darraz","year":"2015","unstructured":"Arias-Darraz, L. et al. A transient receptor potential ion channel in chlamydomonas shares key features with sensory transduction-associated trp channels in mammals. Plant Cell 27, 177\u2013188 (2015).","journal-title":"Plant Cell"},{"key":"428_CR10","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1042\/bj3110041","volume":"311","author":"CCH Petersen","year":"1995","unstructured":"Petersen, C. C. H., Berridge, M. J., Borgese, M. F. & Bennett, D. L. Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues. Biochem. J. 311, 41\u201344 (1995).","journal-title":"Biochem. J."},{"key":"428_CR11","doi-asserted-by":"crossref","unstructured":"Flockerzi, V. & Nilius, B. in Mammalian Transient Receptor Potential (TRP) Cation Channels, Handbook of Experimental Pharmacology 222, 1\u201312 (Springer, 2014).","DOI":"10.1007\/978-3-642-54215-2_1"},{"key":"428_CR12","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S1097-2765(02)00448-3","volume":"9","author":"C Montell","year":"2002","unstructured":"Montell, C. et al. A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 9, 229\u2013231 (2002).","journal-title":"Mol. Cell"},{"key":"428_CR13","doi-asserted-by":"publisher","first-page":"re3","DOI":"10.1126\/stke.2722005re3","volume":"2005","author":"C Montell","year":"2005","unstructured":"Montell, C. The TRP superfamily of cation channels. Sci. STKE 2005, re3\u2013re3 (2005).","journal-title":"Sci. STKE"},{"key":"428_CR14","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/39807","volume":"389","author":"MJ Caterina","year":"1997","unstructured":"Caterina, M. J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816\u2013824 (1997).","journal-title":"Nature"},{"key":"428_CR15","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/S0092-8674(02)00652-9","volume":"108","author":"AM Peier","year":"2002","unstructured":"Peier, A. M. et al. A TRP channel that senses cold stimuli and menthol. Cell 108, 705\u2013715 (2002).","journal-title":"Cell"},{"key":"428_CR16","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1523\/JNEUROSCI.4901-08.2009","volume":"29","author":"A Dhaka","year":"2009","unstructured":"Dhaka, A. et al. TRPV1 is activated by both acidic and basic pH. J. Neurosci. 29, 153\u2013158 (2009).","journal-title":"J. Neurosci."},{"key":"428_CR17","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S0092-8674(00)00143-4","volume":"103","author":"W Liedtke","year":"2000","unstructured":"Liedtke, W. et al. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103, 525\u2013535 (2000).","journal-title":"Cell"},{"key":"428_CR18","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21074","volume":"6","author":"MR Servin-Vences","year":"2017","unstructured":"Servin-Vences, M. R., Moroni, M., Lewin, G. R. & Poole, K. Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes. eLife 6, e21074 (2017).","journal-title":"eLife"},{"key":"428_CR19","doi-asserted-by":"publisher","first-page":"35741","DOI":"10.1074\/jbc.M404164200","volume":"279","author":"H-Z Hu","year":"2004","unstructured":"Hu, H.-Z. et al. 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J. Biol. Chem. 279, 35741\u20138 (2004).","journal-title":"J. Biol. Chem."},{"key":"428_CR20","doi-asserted-by":"crossref","unstructured":"Voets, T. Quantifying and modeling the temperature-dependent gating of TRP channels. in Reviews of Physiology, Biochemistry and Pharmacology 162, 91\u2013119 (Springer, Berlin, Heidelberg, 2012).","DOI":"10.1007\/112_2011_5"},{"key":"428_CR21","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/S0092-8674(02)00719-5","volume":"109","author":"P Launay","year":"2002","unstructured":"Launay, P. et al. TRPM4 Is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell 109, 397\u2013407 (2002).","journal-title":"Cell"},{"key":"428_CR22","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/S0960-9822(03)00431-7","volume":"13","author":"T Hofmann","year":"2003","unstructured":"Hofmann, T., Chubanov, V., Gudermann, T. & Montell, C. TRPM5 is a voltage-modulated and Ca2+-activated monovalent selective cation channel. Curr. Biol. 13, 1153\u20131158 (2003).","journal-title":"Curr. Biol."},{"key":"428_CR23","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/S0306-4522(01)00496-1","volume":"109","author":"A Avelino","year":"2002","unstructured":"Avelino, A., Cruz, C., Nagy, I. & Cruz Ayb, F. Vanilloid receptor 1 expression in the rat urinary tract. Neuroscience 109, 787\u2013798 (2002).","journal-title":"Neuroscience"},{"key":"428_CR24","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1152\/ajprenal.00417.2012","volume":"304","author":"AC Smith","year":"2013","unstructured":"Smith, A. C. et al. TRPM4 channel: a new player in urinary bladder smooth muscle function in rats. Am. J. Physiol. Renal Physiol. 304, 918\u2013929 (2013).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"428_CR25","doi-asserted-by":"publisher","first-page":"F692","DOI":"10.1152\/ajprenal.00599.2009","volume":"298","author":"W Everaerts","year":"2010","unstructured":"Everaerts, W. et al. Functional characterization of transient receptor potential channels in mouse urothelial cells. Am. J. Physiol. Physiol. 298, F692\u2013F701 (2010).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR26","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/cne.24362","volume":"526","author":"NJ Spencer","year":"2018","unstructured":"Spencer, N. J. et al. Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice. J. Comp. Neurol. 526, 707\u2013720 (2018).","journal-title":"J. Comp. Neurol."},{"key":"428_CR27","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1152\/jn.01049.2007","volume":"99","author":"L Xu","year":"2008","unstructured":"Xu, L. & Gebhart, G. F. Characterization of mouse lumbar splanchnic and pelvic nerve urinary bladder mechanosensory afferents. J. Neurophysiol. 99, 244\u2013253 (2008).","journal-title":"J. Neurophysiol."},{"key":"428_CR28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.brainres.2016.06.042","volume":"1648","author":"H Kanda","year":"2016","unstructured":"Kanda, H., Clodfelder-Miller, B. J., Gu, J. G., Ness, T. J. & Deberry, J. J. Electrophysiological properties of lumbosacral primary afferent neurons innervating urothelial and non-urothelial layers of mouse urinary bladder. Brain Res. 1648, 81\u201389 (2016).","journal-title":"Brain Res."},{"key":"428_CR29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.brainres.2017.12.023","volume":"1689","author":"BJ Clodfelder-Miller","year":"2018","unstructured":"Clodfelder-Miller, B. J. et al. Urothelial bladder afferent neurons in the rat are anatomically and neurochemically distinct from non-urothelial afferents. Brain Res. 1689, 45\u201353 (2018).","journal-title":"Brain Res."},{"key":"428_CR30","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/978-3-540-79090-7_4","volume":"194","author":"WC De Groat","year":"2009","unstructured":"De Groat, W. C. & Yoshimura, N. Afferent nerve regulation of bladder function in health and disease. Handb. Exp. Pharmacol. 194, 91\u2013138 (2009).","journal-title":"Handb. Exp. Pharmacol."},{"key":"428_CR31","doi-asserted-by":"publisher","first-page":"5670","DOI":"10.1523\/JNEUROSCI.21-15-05670.2001","volume":"21","author":"M Vlaskovska","year":"2001","unstructured":"Vlaskovska, M. et al. P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J. Neurosci. 21, 5670\u20135677 (2001).","journal-title":"J. Neurosci."},{"key":"428_CR32","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1038\/35039519","volume":"407","author":"DA Cockayne","year":"2000","unstructured":"Cockayne, D. A. et al. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407, 1011\u20131015 (2000).","journal-title":"Nature"},{"key":"428_CR33","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/sj.ki.5002439","volume":"72","author":"G Apodaca","year":"2007","unstructured":"Apodaca, G., Balestreire, E. & Birder, L. A. The uroepithelial-associated sensory web. Kidney Int. 72, 1057\u20131064 (2007).","journal-title":"Kidney Int."},{"key":"428_CR34","doi-asserted-by":"publisher","first-page":"F708","DOI":"10.1152\/ajprenal.00387.2016","volume":"311","author":"L Durnin","year":"2016","unstructured":"Durnin, L. et al. Urothelial purine release during filling of murine and primate bladders. Am. J. Physiol. Physiol. 311, F708\u2013F716 (2016).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR35","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1085\/jgp.201511550","volume":"147","author":"TJ Heppner","year":"2016","unstructured":"Heppner, T. J., Tykocki, N. R., Hill-Eubanks, D. & Nelson, M. T. Transient contractions of urinary bladder smooth muscle are drivers of afferent nerve activity during filling. J. Gen. Physiol. 147, 323\u2013335 (2016).","journal-title":"J. Gen. Physiol."},{"key":"428_CR36","doi-asserted-by":"publisher","first-page":"F932","DOI":"10.1152\/ajprenal.00334.2011","volume":"301","author":"W Yu","year":"2011","unstructured":"Yu, W. & Hill, W. G. Defining protein expression in the urothelium: a problem of more than transitional interest. Am. J. Physiol. Physiol. 301, F932\u2013F942 (2011).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR37","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00210-008-0391-7","volume":"379","author":"W Everaerts","year":"2009","unstructured":"Everaerts, W. et al. Where is TRPV1 expressed in the bladder, do we see the real channel? Naunyn Schmiedebergs Arch. Pharmacol. 379, 421\u2013425 (2009).","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"428_CR38","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1111\/bju.12876","volume":"115","author":"Y Deruyver","year":"2015","unstructured":"Deruyver, Y., Voets, T., De Ridder, D. & Everaerts, W. Transient receptor potential channel modulators as pharmacological treatments for lower urinary tract symptoms (LUTS): myth or reality? BJU Int. 115, 686\u2013697 (2015).","journal-title":"BJU Int."},{"key":"428_CR39","doi-asserted-by":"publisher","first-page":"13396","DOI":"10.1073\/pnas.231243698","volume":"98","author":"LA Birder","year":"2001","unstructured":"Birder, L. A. et al. Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. PNAS 98, 13396\u201313401 (2001).","journal-title":"PNAS"},{"key":"428_CR40","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0022-5347(05)64910-5","volume":"168","author":"D Ost","year":"2002","unstructured":"Ost, D., Roskams, T., Van Der Aa, F. & De Ridder, D. Topography of the vanilloid receptor in the human bladder: more than just the nerve fibers. J. Urol. 168, 293\u2013297 (2002).","journal-title":"J. Urol."},{"key":"428_CR41","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.eururo.2004.08.007","volume":"46","author":"M Lazzeri","year":"2004","unstructured":"Lazzeri, M. et al. Immunohistochemical evidence of vanilloid receptor 1 in normal human urinary bladder. Eur. Urol. 46, 792\u2013798 (2004).","journal-title":"Eur. Urol."},{"key":"428_CR42","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.eururo.2005.05.018","volume":"48","author":"M Lazzeri","year":"2005","unstructured":"Lazzeri, M. et al. Transient receptor potential vanilloid type 1 (TRPV1) expression changes from normal urothelium to transitional cell carcinoma of human bladder. Eur. Urol. 48, 691\u2013698 (2005).","journal-title":"Eur. Urol."},{"key":"428_CR43","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.urology.2004.10.007","volume":"65","author":"A Apostolidis","year":"2005","unstructured":"Apostolidis, A. et al. Capsaicin receptor TRPV1 in urothelium of neurogenic human bladders and effect of intravesical resiniferatoxin. Urology 65, 400\u2013405 (2005).","journal-title":"Urology"},{"key":"428_CR44","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/j.1464-410X.2007.07151.x","volume":"100","author":"H-T Liu","year":"2007","unstructured":"Liu, H.-T. & Kuo, H.-C. Increased expression of transient receptor potential vanilloid subfamily 1 in the bladder predicts the response to intravesical instillations of resiniferatoxin in patients with refractory idiopathic detrusor overactivity. BJU Int. 100, 1086\u20131090 (2007).","journal-title":"BJU Int."},{"key":"428_CR45","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.regpep.2011.02.004","volume":"167","author":"YJ Heng","year":"2011","unstructured":"Heng, Y. J., Saunders, C. I. M., Kunde, D. A. & Geraghty, D. P. TRPV1, NK1 receptor and substance P immunoreactivity and gene expression in the rat lumbosacral spinal cord and urinary bladder after systemic, low dose vanilloid administration. Regul. Pept. 167, 250\u2013258 (2011).","journal-title":"Regul. Pept."},{"key":"428_CR46","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1369\/jhc.2008.951962","volume":"57","author":"T Yamada","year":"2009","unstructured":"Yamada, T. et al. Differential localizations of the transient receptor potential channels TRPV4 and TRPV1 in the mouse urinary bladder. J. Histochem. Cytochem. 57, 277\u2013287 (2009).","journal-title":"J. Histochem. Cytochem."},{"key":"428_CR47","doi-asserted-by":"publisher","first-page":"21257","DOI":"10.1074\/jbc.M109.020206","volume":"284","author":"T Mochizuki","year":"2009","unstructured":"Mochizuki, T. et al. The TRPV4 cation channel mediates stretch-evoked Ca 2 influx and ATP release in primary urothelial cell cultures. J. Biol. Chem. 284, 21257\u201321264 (2009).","journal-title":"J. Biol. Chem."},{"key":"428_CR48","doi-asserted-by":"publisher","first-page":"156","DOI":"10.4161\/chan.3.3.8555","volume":"3","author":"X Xu","year":"2009","unstructured":"Xu, X. et al. Functional TRPV4 channels and an absence of capsaicin-evoked currents in freshly-isolated, guinea-pig urothelial cells. Channels 3, 156\u2013160 (2009).","journal-title":"Channels"},{"key":"428_CR49","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.juro.2013.01.048","volume":"190","author":"LM O\u2019Mullane","year":"2013","unstructured":"O\u2019Mullane, L. M., Keast, J. R. & Osborne, P. B. Co-cultures provide a new tool to probe communication between adult sensory neurons and urothelium. J. Urol. 190, 737\u2013745 (2013).","journal-title":"J. Urol."},{"key":"428_CR50","doi-asserted-by":"publisher","first-page":"F396","DOI":"10.1152\/ajprenal.00127.2013","volume":"305","author":"S Shabir","year":"2013","unstructured":"Shabir, S. et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am. J. Physiol. Physiol. 305, F396\u2013F406 (2013).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR51","doi-asserted-by":"publisher","first-page":"F892","DOI":"10.1152\/ajprenal.90718.2008","volume":"296","author":"FA Kullmann","year":"2009","unstructured":"Kullmann, F. A., Shah, M. A., Birder, L. A. & de Groat, W. C. Functional TRP and ASIC-like channels in cultured urothelial cells from the rat. Am. J. Physiol. Renal Physiol. 296, F892\u2013F901 (2009).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"428_CR52","doi-asserted-by":"publisher","first-page":"5067","DOI":"10.1523\/JNEUROSCI.6451-10.2011","volume":"31","author":"DJ Cavanaugh","year":"2011","unstructured":"Cavanaugh, D. J. et al. Trpv1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells. J. Neurosci. 31, 5067\u201377 (2011).","journal-title":"J. Neurosci."},{"key":"428_CR53","doi-asserted-by":"publisher","first-page":"13025","DOI":"10.1523\/JNEUROSCI.2589-11.2011","volume":"31","author":"A Menigoz","year":"2011","unstructured":"Menigoz, A. & Boudes, M. The expression pattern of TRPV1 in brain. J. Neurosci. 31, 13025\u201313027 (2011).","journal-title":"J. Neurosci."},{"key":"428_CR54","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.tig.2017.12.008","volume":"34","author":"AJ Song","year":"2018","unstructured":"Song, A. J. & Palmiter, R. D. Detecting and avoiding problems when using the Cre\/lox system. Trends Genet. 34, 333\u2013340 (2018).","journal-title":"Trends Genet."},{"key":"428_CR55","unstructured":"Tabula Muris. https:\/\/tabula-muris.ds.czbiohub.org\/ (2018)."},{"key":"428_CR56","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/s41586-018-0590-4","volume":"562","author":"N Schaum","year":"2018","unstructured":"Schaum, N. et al. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature 562, 367\u2013372 (2018).","journal-title":"Nature"},{"key":"428_CR57","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.eururo.2007.10.024","volume":"53","author":"T Streng","year":"2008","unstructured":"Streng, T. et al. Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur. Urol. 53, 391\u2013400 (2008).","journal-title":"Eur. Urol."},{"key":"428_CR58","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.urology.2007.11.127","volume":"72","author":"S Du","year":"2008","unstructured":"Du, S. et al. Differential expression profile of cold (TRPA1) and cool (TRPM8) receptors in human urogenital organs. Urology 72, 450\u2013455 (2008).","journal-title":"Urology"},{"key":"428_CR59","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.eururo.2008.04.042","volume":"55","author":"C Gratzke","year":"2009","unstructured":"Gratzke, C. et al. Transient receptor potential A1 (TRPA1) activity in the human urethra \u2014 evidence for a functional role for TRPA1 in the outflow region. Eur. Urol. 55, 696\u2013704 (2009).","journal-title":"Eur. Urol."},{"key":"428_CR60","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1097\/01.ju.0000134880.55119.cf","volume":"172","author":"RJ Stein","year":"2004","unstructured":"Stein, R. J. et al. Cool (TRPM8) and Hot (TRPV1) receptors in the bladder and male genital tract. J. Urol. 172, 1175\u20131178 (2004).","journal-title":"J. Urol."},{"key":"428_CR61","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.cell.2018.06.021","volume":"174","author":"A Zeisel","year":"2018","unstructured":"Zeisel, A. et al. Molecular architecture of the mouse nervous system. Cell 174, 999\u20131014.e22 (2018).","journal-title":"Cell"},{"key":"428_CR62","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.1172\/JCI31766","volume":"117","author":"T Gevaert","year":"2007","unstructured":"Gevaert, T. et al. Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J. Clin. Invest. 117, 3453\u20133462 (2007).","journal-title":"J. Clin. Invest."},{"key":"428_CR63","doi-asserted-by":"publisher","first-page":"19084","DOI":"10.1073\/pnas.1005333107","volume":"107","author":"W Everaerts","year":"2010","unstructured":"Everaerts, W. et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc. Natl Acad. Sci. USA 107, 19084\u201319089 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"428_CR64","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1124\/jpet.108.139295","volume":"326","author":"KS Thorneloe","year":"2008","unstructured":"Thorneloe, K. S. et al. N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: part I. J. Pharmacol. Exp. Ther. 326, 432\u201342 (2008).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"428_CR65","doi-asserted-by":"publisher","first-page":"F1063","DOI":"10.1152\/ajprenal.00234.2016","volume":"311","author":"TX Phan","year":"2016","unstructured":"Phan, T. X., Ton, H. T., Chen, Y., Basha, M. E. & Ahern, G. P. Sex-dependent expression of TRPV1 in bladder arterioles. Am. J. Physiol. Physiol. 311, F1063\u2013F1073 (2016).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR66","doi-asserted-by":"publisher","first-page":"F49","DOI":"10.1152\/ajprenal.00349.2010","volume":"300","author":"W Yu","year":"2010","unstructured":"Yu, W., Hill, W. G., Apodaca, G. & Zeidel, M. L. Expression and distribution of transient receptor potential (TRP) channels in bladder epithelium. Am. J. Physiol. Physiol. 300, F49\u2013F59 (2010).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR67","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-14-21","volume":"14","author":"I Vandewauw","year":"2013","unstructured":"Vandewauw, I., Owsianik, G. & Voets, T. Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse. BMC Neurosci. 14, 21 (2013).","journal-title":"BMC Neurosci."},{"key":"428_CR68","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1242\/dev.063594","volume":"138","author":"SD Harding","year":"2011","unstructured":"Harding, S. D. et al. The GUDMAP database \u2014 an online resource for genitourinary research. Development 138, 2845\u20132853 (2011).","journal-title":"Development"},{"key":"428_CR69","unstructured":"GUDMAP. https:\/\/www.gudmap.org\/id\/16-DW7R@2VC-DWXQ-2KDE."},{"key":"428_CR70","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nn.3881","volume":"18","author":"D Usoskin","year":"2015","unstructured":"Usoskin, D. et al. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat. Neurosci. 18, 145\u2013153 (2015).","journal-title":"Nat. Neurosci."},{"key":"428_CR71","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1136\/gutjnl-2017-315631","volume":"68","author":"JRF Hockley","year":"2019","unstructured":"Hockley, J. R. F. et al. Single-cell RNAseq reveals seven classes of colonic sensory neuron. Gut 68, 633\u2013644 (2019).","journal-title":"Gut"},{"key":"428_CR72","doi-asserted-by":"publisher","first-page":"47044","DOI":"10.1074\/jbc.M208277200","volume":"277","author":"H Watanabe","year":"2002","unstructured":"Watanabe, H. et al. Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J. Biol. Chem. 277, 47044\u201347051 (2002).","journal-title":"J. Biol. Chem."},{"key":"428_CR73","doi-asserted-by":"publisher","first-page":"6408","DOI":"10.1523\/JNEUROSCI.22-15-06408.2002","volume":"22","author":"AD G\u00fcler","year":"2002","unstructured":"G\u00fcler, A. D. et al. Heat-evoked activation of the ion channel, TRPV4. J. Neurosci. 22, 6408\u20136414 (2002).","journal-title":"J. Neurosci."},{"key":"428_CR74","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/nature01807","volume":"424","author":"H Watanabe","year":"2003","unstructured":"Watanabe, H. et al. Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 424, 434\u2013438 (2003).","journal-title":"Nature"},{"key":"428_CR75","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.bbrc.2009.09.007","volume":"389","author":"F Vincent","year":"2009","unstructured":"Vincent, F. et al. Identification and characterization of novel TRPV4 modulators. Biochem. Biophys. Res. Commun. 389, 490\u2013494 (2009).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"428_CR76","doi-asserted-by":"publisher","first-page":"159ra148","DOI":"10.1126\/scitranslmed.3004276","volume":"4","author":"KS Thorneloe","year":"2012","unstructured":"Thorneloe, K. S. et al. An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci. Transl. Med. 4, 159ra148 (2012).","journal-title":"Sci. Transl. Med."},{"key":"428_CR77","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.pbiomolbio.2009.10.002","volume":"103","author":"W Everaerts","year":"2010","unstructured":"Everaerts, W., Nilius, B. & Owsianik, G. The vanilloid transient receptor potential channel TRPV4: From structure to disease. Prog. Biophys. Mol. Biol. 103, 2\u201317 (2010).","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"428_CR78","doi-asserted-by":"publisher","first-page":"F17","DOI":"10.1152\/ajprenal.00397.2003","volume":"287","author":"W Tian","year":"2004","unstructured":"Tian, W. et al. Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments. Am. J. Physiol. Physiol. 287, F17\u2013F24 (2004).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR79","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.cmet.2008.08.002","volume":"8","author":"R Masuyama","year":"2008","unstructured":"Masuyama, R. et al. TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab. 8, 257\u2013265 (2008).","journal-title":"Cell Metab."},{"key":"428_CR80","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1007\/s00125-008-1111-z","volume":"51","author":"S Casas","year":"2008","unstructured":"Casas, S., Novials, A., Reimann, F., Gomis, R. & Gribble, F. M. Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4. Diabetologia 51, 2252\u20132262 (2008).","journal-title":"Diabetologia"},{"key":"428_CR81","doi-asserted-by":"publisher","first-page":"32037","DOI":"10.1074\/jbc.M303251200","volume":"278","author":"M-K Chung","year":"2003","unstructured":"Chung, M.-K., Lee, H. & Caterina, M. J. Warm temperatures activate TRPV4 in mouse 308 keratinocytes. J. Biol. Chem. 278, 32037\u201346 (2003).","journal-title":"J. Biol. Chem."},{"key":"428_CR82","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1080\/10799890701402446","volume":"27","author":"R Fian","year":"2007","unstructured":"Fian, R. et al. The contribution of TRPV4-mediated calcium signaling to calcium homeostasis in endothelial cells. J. Recept. Signal. Transduct. 27, 113\u2013124 (2007).","journal-title":"J. Recept. Signal. Transduct."},{"key":"428_CR83","doi-asserted-by":"publisher","first-page":"12611","DOI":"10.1073\/pnas.0803970105","volume":"105","author":"IM Lorenzo","year":"2008","unstructured":"Lorenzo, I. M., Liedtke, W., Sanderson, M. J. & Valverde, M. A. TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells. Proc. Natl Acad. Sci. USA 105, 12611\u201312616 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"428_CR84","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1124\/jpet.107.125435","volume":"323","author":"LA Birder","year":"2007","unstructured":"Birder, L. A. et al. Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. J. Pharmacol. Exp. Ther. 323, 227\u2013235 (2007).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"428_CR85","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.juro.2011.04.107","volume":"186","author":"DAW Janssen","year":"2011","unstructured":"Janssen, D. A. W. et al. The mechanoreceptor TRPV4 is localized in adherence junctions of the human bladder urothelium: a morphological study. J. Urol. 186, 1121\u20131127 (2011).","journal-title":"J. Urol."},{"key":"428_CR86","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/apha.12701","volume":"218","author":"DAW Janssen","year":"2016","unstructured":"Janssen, D. A. W. et al. TRPV4 channels in the human urogenital tract play a role in cell junction formation and epithelial barrier. Acta Physiol. 218, 38\u201348 (2016).","journal-title":"Acta Physiol."},{"key":"428_CR87","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1096\/fj.201900961RR","volume":"34","author":"MWG Roberts","year":"2020","unstructured":"Roberts, M. W. G. et al. TRPV4 receptor as a functional sensory molecule in bladder urothelium: stretch-independent, tissue-specific actions and pathological implications. FASEB J. 34, 263\u2013286 (2020).","journal-title":"FASEB J."},{"key":"428_CR88","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1046\/j.1464-410x.1999.00310.x","volume":"84","author":"Namasivayam, Eardley & Morrison","year":"2001","unstructured":"Namasivayam, Eardley & Morrison. Purinergic sensory neurotransmission in the urinary bladder: an in vitro study in the rat. BJU Int. 84, 854\u2013860 (2001).","journal-title":"BJU Int."},{"key":"428_CR89","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1113\/jphysiol.2001.013469","volume":"541","author":"W Rong","year":"2002","unstructured":"Rong, W., Spyer, K. M. & Burnstock, G. Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder. J. Physiol. 541, 591\u2013600 (2002).","journal-title":"J. Physiol."},{"key":"428_CR90","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1113\/jphysiol.2005.088435","volume":"567","author":"DA Cockayne","year":"2005","unstructured":"Cockayne, D. A. et al. P2X2 knockout mice and P2X2\/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J. Physiol. 567, 621\u2013639 (2005).","journal-title":"J. Physiol."},{"key":"428_CR91","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/nau.21212","volume":"31","author":"N Aizawa","year":"2012","unstructured":"Aizawa, N., Wyndaele, J.-J., Homma, Y. & Igawa, Y. Effects of TRPV4 cation channel activation on the primary bladder afferent activities of the rat. Neurourol. Urodyn. 31, 148\u2013155 (2012).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR92","doi-asserted-by":"publisher","first-page":"C96","DOI":"10.1152\/ajpcell.00559.2002","volume":"285","author":"A Mizuno","year":"2003","unstructured":"Mizuno, A., Matsumoto, N., Imai, M. & Suzuki, M. Impaired osmotic sensation in mice lacking TRPV4. Am. J. Physiol. Physiol. 285, C96\u2013C101 (2003).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR93","doi-asserted-by":"publisher","first-page":"13698","DOI":"10.1073\/pnas.1735416100","volume":"100","author":"W Liedtke","year":"2003","unstructured":"Liedtke, W. & Friedman, J. M. Abnormal osmotic regulation in trpv4-\/- mice. PNAS 100, 13698\u201313703 (2003).","journal-title":"PNAS"},{"key":"428_CR94","doi-asserted-by":"publisher","first-page":"F1128","DOI":"10.1152\/ajprenal.00016.2015","volume":"308","author":"M Yoshiyama","year":"2015","unstructured":"Yoshiyama, M. et al. Functional roles of TRPV1 and TRPV4 in control of lower urinary tract activity: dual analysis of behavior and reflex during the micturition cycle. Am. J. Physiol. Physiol. 308, F1128\u2013F1134 (2015).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR95","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.eururo.2018.05.020","volume":"74","author":"Y Deruyver","year":"2018","unstructured":"Deruyver, Y. et al. Intravesical activation of the cation channel TRPV4 improves bladder function in a rat model for detrusor underactivity. Eur. Urol. 74, 336\u2013345 (2018).","journal-title":"Eur. Urol."},{"key":"428_CR96","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1002\/nau.23400","volume":"37","author":"T Ihara","year":"2018","unstructured":"Ihara, T. et al. The circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells. Neurourol. Urodyn. 37, 942\u2013951 (2018).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR97","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23115-w","volume":"8","author":"T Ihara","year":"2018","unstructured":"Ihara, T. et al. The oscillation of intracellular Ca2+ influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium. Sci. Rep. 8, 5699 (2018).","journal-title":"Sci. Rep."},{"key":"428_CR98","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1002\/nau.23062","volume":"36","author":"T Ihara","year":"2017","unstructured":"Ihara, T. et al. The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria. Neurourol. Urodyn. 36, 1034\u20131038 (2017).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR99","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/S0092-8674(00)81199-X","volume":"93","author":"A Balsalobre","year":"1998","unstructured":"Balsalobre, A., Damiola, F. & Schibler, U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 93, 929\u2013937 (1998).","journal-title":"Cell"},{"key":"428_CR100","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3389\/fimmu.2020.00799","volume":"11","author":"YA Alpizar","year":"2020","unstructured":"Alpizar, Y. A. et al. TRPV4 mediates acute bladder responses to bacterial lipopolysaccharides. Front. Immunol. 11, 799 (2020).","journal-title":"Front. Immunol."},{"key":"428_CR101","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/18906","volume":"398","author":"MJ Caterina","year":"1999","unstructured":"Caterina, M. J., Rosen, T. A., Tominaga, M., Brake, A. J. & Julius, D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398, 436\u2013441 (1999).","journal-title":"Nature"},{"key":"428_CR102","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/11086","volume":"1","author":"M Kanzaki","year":"1999","unstructured":"Kanzaki, M. et al. Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nat. Cell Biol. 1, 165\u2013170 (1999).","journal-title":"Nat. Cell Biol."},{"key":"428_CR103","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1161\/01.RES.0000097263.10220.0C","volume":"93","author":"K Muraki","year":"2003","unstructured":"Muraki, K. et al. TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ. Res. 93, 829\u2013838 (2003).","journal-title":"Circ. Res."},{"key":"428_CR104","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.neulet.2007.08.035","volume":"425","author":"S Bang","year":"2007","unstructured":"Bang, S., Kim, K. Y., Yoo, S., Lee, S.-H. & Hwang, S. W. Transient receptor potential V2 expressed in sensory neurons is activated by probenecid. Neurosci. Lett. 425, 120\u2013125 (2007).","journal-title":"Neurosci. Lett."},{"key":"428_CR105","doi-asserted-by":"publisher","first-page":"6231","DOI":"10.1523\/JNEUROSCI.0504-08.2008","volume":"28","author":"N Qin","year":"2008","unstructured":"Qin, N. et al. TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J. Neurosci. 28, 6231\u20136238 (2008).","journal-title":"J. Neurosci."},{"key":"428_CR106","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1523\/JNEUROSCI.5830-09.2010","volume":"30","author":"K Shibasaki","year":"2010","unstructured":"Shibasaki, K., Murayama, N., Ono, K., Ishizaki, Y. & Tominaga, M. TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons. J. Neurosci. 30, 4601\u20134612 (2010).","journal-title":"J. Neurosci."},{"key":"428_CR107","first-page":"615","volume":"32","author":"K De Clercq","year":"2017","unstructured":"De Clercq, K. et al. The functional expression of transient receptor potential channels in the mouse endometrium. Hum. Reprod. 32, 615\u2013630 (2017).","journal-title":"Hum. Reprod."},{"key":"428_CR108","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4932","volume":"5","author":"Y Katanosaka","year":"2014","unstructured":"Katanosaka, Y. et al. TRPV2 is critical for the maintenance of cardiac structure and function in mice. Nat. Commun. 5, 3932 (2014).","journal-title":"Nat. Commun."},{"key":"428_CR109","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/ni.1842","volume":"11","author":"TM Link","year":"2010","unstructured":"Link, T. M. et al. TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat. Immunol. 11, 232\u2013239 (2010).","journal-title":"Nat. Immunol."},{"key":"428_CR110","doi-asserted-by":"publisher","first-page":"11425","DOI":"10.1523\/JNEUROSCI.1384-09.2011","volume":"31","author":"U Park","year":"2011","unstructured":"Park, U. et al. TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception. J. Neurosci. 31, 11425\u201311436 (2011).","journal-title":"J. Neurosci."},{"key":"428_CR111","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.eururo.2007.10.016","volume":"54","author":"S Caprodossi","year":"2008","unstructured":"Caprodossi, S. et al. Transient receptor potential vanilloid type 2 (TRPV2) expression in normal urothelium and in urothelial carcinoma of human bladder: correlation with the pathologic stage. Eur. Urol. 54, 612\u2013620 (2008).","journal-title":"Eur. Urol."},{"key":"428_CR112","doi-asserted-by":"publisher","first-page":"509.e1","DOI":"10.1016\/j.urology.2010.03.029","volume":"76","author":"T Yamada","year":"2010","unstructured":"Yamada, T. et al. TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer. Urology 76, 509.e1\u2013509.e7 (2010).","journal-title":"Urology"},{"key":"428_CR113","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1108","volume":"1","author":"LV Ryazanova","year":"2010","unstructured":"Ryazanova, L. V. et al. TRPm7 is essential for Mg2+ homeostasis in mammals. Nat. Commun. 1, 109 (2010).","journal-title":"Nat. Commun."},{"key":"428_CR114","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1080\/10799890600637506","volume":"26","author":"E Fonfria","year":"2006","unstructured":"Fonfria, E. et al. Tissue distribution profiles of the human TRPM cation channel family. J. Recept. Signal. Transduct. 26, 159\u2013178 (2006).","journal-title":"J. Recept. Signal. Transduct."},{"key":"428_CR115","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1126\/science.1163493","volume":"322","author":"J Jin","year":"2008","unstructured":"Jin, J. et al. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science 322, 756\u2013760 (2008).","journal-title":"Science"},{"key":"428_CR116","doi-asserted-by":"publisher","first-page":"29882","DOI":"10.1074\/jbc.M115.667899","volume":"290","author":"M Watanabe","year":"2015","unstructured":"Watanabe, M. et al. Trpm7 protein contributes to intercellular junction formation in mouse urothelium. J. Biol. Chem. 290, 29882\u201329892 (2015).","journal-title":"J. Biol. Chem."},{"key":"428_CR117","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/22761","volume":"400","author":"PM Zygmunt","year":"1999","unstructured":"Zygmunt, P. M. et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400, 452\u2013457 (1999).","journal-title":"Nature"},{"key":"428_CR118","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1124\/pr.113.008268","volume":"66","author":"B Nilius","year":"2014","unstructured":"Nilius, B. & Szallasi, A. Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine. Pharmacol. Rev. 66, 676\u2013814 (2014).","journal-title":"Pharmacol. Rev."},{"key":"428_CR119","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0169-328X(94)90225-9","volume":"23","author":"G Acs","year":"1994","unstructured":"Acs, G., Palkovits, M. & Blumberg, P. M. [3H]Resiniferatoxin binding by the human vanilloid (capsaicin) receptor. Mol. Brain Res. 23, 185\u2013190 (1994).","journal-title":"Mol. Brain Res."},{"key":"428_CR120","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0304-3959(95)00145-X","volume":"65","author":"TK Baumann","year":"1996","unstructured":"Baumann, T. K., Burchiel, K. J., Ingram, S. L. & Martenson, M. E. Responses of adult human dorsal root ganglion neurons in culture to capsaicin and low pH. Pain 65, 31\u201338 (1996).","journal-title":"Pain"},{"key":"428_CR121","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1006\/bbrc.2001.5299","volume":"285","author":"M Denda","year":"2001","unstructured":"Denda, M. et al. Immunoreactivity of VR1 on epidermal keratinocyte of human skin. Biochem. Biophys. Res. Commun. 285, 1250\u20131252 (2001).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"428_CR122","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/nn902","volume":"5","author":"LA Birder","year":"2002","unstructured":"Birder, L. A. et al. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat. Neurosci. 5, 856\u2013860 (2002).","journal-title":"Nat. Neurosci."},{"key":"428_CR123","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/S0306-4522(01)00373-6","volume":"107","author":"JF Sanchez","year":"2001","unstructured":"Sanchez, J. F., Krause, J. E. & Cortright, D. N. The distribution and regulation of vanilloid receptor VR1 and VR1 5\u2032 splice variant RNA expression in rat. Neuroscience 107, 373\u2013381 (2001).","journal-title":"Neuroscience"},{"key":"428_CR124","unstructured":"Mouse Brain Atlas. www.mousebrain.org."},{"key":"428_CR125","first-page":"77","volume":"151","author":"CA Maggi","year":"1990","unstructured":"Maggi, C. A. The dual function of capsaicin-sensitive sensory nerves in the bladder and urethra. Ciba Found. Symp. 151, 77\u201383 (1990).","journal-title":"Ciba Found. Symp."},{"key":"428_CR126","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/s00535-011-0495-6","volume":"47","author":"MA Engel","year":"2012","unstructured":"Engel, M. A. et al. The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons. J. Gastroenterol. 47, 256\u2013265 (2012).","journal-title":"J. Gastroenterol."},{"key":"428_CR127","doi-asserted-by":"publisher","first-page":"4981","DOI":"10.1523\/JNEUROSCI.5490-08.2009","volume":"29","author":"J Meng","year":"2009","unstructured":"Meng, J. et al. Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential. J. Neurosci. 29, 4981\u201392 (2009).","journal-title":"J. Neurosci."},{"key":"428_CR128","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1007\/s13238-017-0395-5","volume":"8","author":"O Gouin","year":"2017","unstructured":"Gouin, O. et al. TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization. Protein Cell 8, 644\u2013661 (2017).","journal-title":"Protein Cell"},{"key":"428_CR129","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.mcn.2014.04.007","volume":"61","author":"A Boillat","year":"2014","unstructured":"Boillat, A., Alijevic, O. & Kellenberger, S. Calcium entry via TRPV1 but not ASICs induces neuropeptide release from sensory neurons. Mol. Cell. Neurosci. 61, 13\u201322 (2014).","journal-title":"Mol. Cell. Neurosci."},{"key":"428_CR130","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1046\/j.1464-410x.2001.02190.x","volume":"87","author":"Y Yiangou","year":"2002","unstructured":"Yiangou, Y. et al. Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder. BJU Int. 87, 774\u2013779 (2002).","journal-title":"BJU Int."},{"key":"428_CR131","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.bbadis.2007.04.003","volume":"1772","author":"LA Birder","year":"2007","unstructured":"Birder, L. A. TRPs in bladder diseases. Biochim. Biophys. Acta 1772, 879\u201384 (2007).","journal-title":"Biochim. Biophys. Acta"},{"key":"428_CR132","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.pain.2008.03.020","volume":"139","author":"Z-Y Wang","year":"2008","unstructured":"Wang, Z.-Y., Wang, P., Voznika Merriam, F. & Bjorling, D. E. Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice. Pain 139, 158\u2013167 (2008).","journal-title":"Pain"},{"key":"428_CR133","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1113\/jphysiol.2007.139147","volume":"583","author":"D Daly","year":"2007","unstructured":"Daly, D., Rong, W., Chess-Williams, R., Chapple, C. & Grundy, D. Bladder afferent sensitivity in wild-type and TRPV1 knockout mice. J. Physiol. 583, 663\u2013674 (2007).","journal-title":"J. Physiol."},{"key":"428_CR134","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1152\/ajprenal.00435.2019","volume":"318","author":"L Grundy","year":"2020","unstructured":"Grundy, L. et al. Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H 1 receptor and TRPV1. Am. J. Physiol. Renal Physiol. 318, 298\u2013314 (2020).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"428_CR135","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18136-w","volume":"8","author":"L Grundy","year":"2018","unstructured":"Grundy, L., Daly, D. M., Chapple, C., Grundy, D. & Chess-Williams, R. TRPV1 enhances the afferent response to P2X receptor activation in the mouse urinary bladder. Sci. Rep. 8, 197 (2018).","journal-title":"Sci. Rep."},{"key":"428_CR136","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nature02282","volume":"427","author":"S-E Jordt","year":"2004","unstructured":"Jordt, S.-E. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427, 260\u2013265 (2004).","journal-title":"Nature"},{"key":"428_CR137","doi-asserted-by":"publisher","first-page":"12248","DOI":"10.1073\/pnas.0505356102","volume":"102","author":"DM Bautista","year":"2005","unstructured":"Bautista, D. M. et al. Pungent products from garlic activate the sensory ion channel TRPA1. Proc. Natl Acad. Sci. USA 102, 12248\u201312252 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"428_CR138","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4125","volume":"5","author":"V Meseguer","year":"2014","unstructured":"Meseguer, V. et al. TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins. Nat. Commun. 5, 3125 (2014).","journal-title":"Nat. Commun."},{"key":"428_CR139","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1172\/JCI34192","volume":"118","author":"BF Bessac","year":"2008","unstructured":"Bessac, B. F. et al. TRPA1 is a major oxidant sensor in murine airway sensory neurons. J. Clin. Invest. 118, 1899\u20131910 (2008).","journal-title":"J. Clin. Invest."},{"key":"428_CR140","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1146\/annurev-physiol-030212-183811","volume":"75","author":"DM Bautista","year":"2013","unstructured":"Bautista, D. M., Pellegrino, M. & Tsunozaki, M. TRPA1: a gatekeeper for inflammation. Annu. Rev. Physiol. 75, 181\u2013200 (2013).","journal-title":"Annu. Rev. Physiol."},{"key":"428_CR141","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1523\/JNEUROSCI.5369-07.2008","volume":"28","author":"DA Andersson","year":"2008","unstructured":"Andersson, D. A., Gentry, C., Moss, S. & Bevan, S. Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J. Neurosci. 28, 2485\u20132494 (2008).","journal-title":"J. Neurosci."},{"key":"428_CR142","doi-asserted-by":"publisher","first-page":"16901","DOI":"10.1073\/pnas.1412689111","volume":"111","author":"L Moparthi","year":"2014","unstructured":"Moparthi, L. et al. Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain. Proc. Natl Acad. Sci. USA 111, 16901\u201316906 (2014).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"428_CR143","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/S0896-6273(04)00150-3","volume":"41","author":"M Bandell","year":"2004","unstructured":"Bandell, M. et al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41, 849\u2013857 (2004).","journal-title":"Neuron"},{"key":"428_CR144","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/nature26137","volume":"555","author":"I Vandewauw","year":"2018","unstructured":"Vandewauw, I. et al. A TRP channel trio mediates acute noxious heat sensing. Nature 555, 662\u2013666 (2018).","journal-title":"Nature"},{"key":"428_CR145","first-page":"7131","volume":"20","author":"K Nagata","year":"2005","unstructured":"Nagata, K., Duggan, A., Kumar, G. & Garc\u00eda-A\u00f1overos, J. Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J. Neurosci. 20, 7131\u20137142 (2005).","journal-title":"J. Neurosci."},{"key":"428_CR146","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.joen.2012.04.024","volume":"38","author":"YS Kim","year":"2012","unstructured":"Kim, Y. S. et al. Expression of transient receptor potential ankyrin 1 in human dental pulp. J. Endod. 38, 1087\u20131092 (2012).","journal-title":"J. Endod."},{"key":"428_CR147","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.joen.2010.12.017","volume":"37","author":"IA El Karim","year":"2011","unstructured":"El Karim, I. A. et al. Human dental pulp fibroblasts express the \u201cCold-sensing\u201d transient receptor potential channels TRPA1 and TRPM8. J. Endod. 37, 473\u2013478 (2011).","journal-title":"J. Endod."},{"key":"428_CR148","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","volume":"112","author":"GM Story","year":"2003","unstructured":"Story, G. M. et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112, 819\u2013829 (2003).","journal-title":"Cell"},{"key":"428_CR149","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/112_2014_18","volume":"167","author":"R Nassini","year":"2014","unstructured":"Nassini, R. Materazzi, S., Benemei, S. & Geppetti, P. The TRPA1 channel in inflammatory and neuropathic pain and migraine. Rev. Physiol. Biochem. Pharmacol. 167, 1\u201343 (2014).","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"428_CR150","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117770","volume":"10","author":"LJ Moilanen","year":"2015","unstructured":"Moilanen, L. J., H\u00e4m\u00e4l\u00e4inen, M., Lehtim\u00e4ki, L., Nieminen, R. M. & Moilanen, E. Urate crystal induced inflammation and joint pain are reduced in transient receptor potential ankyrin 1 deficient mice \u2014 potential role for transient receptor potential ankyrin 1 in gout. PLoS One 10, e0117770 (2015).","journal-title":"PLoS One"},{"key":"428_CR151","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1016\/j.joca.2015.09.008","volume":"23","author":"LJ Moilanen","year":"2015","unstructured":"Moilanen, L. J. et al. Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice \u2014 potential role of TRPA1 in osteoarthritis. Osteoarthritis Cartilage 23, 2017\u20132026 (2015).","journal-title":"Osteoarthritis Cartilage"},{"key":"428_CR152","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.urology.2007.06.1110","volume":"70","author":"S Du","year":"2007","unstructured":"Du, S., Araki, I., Yoshiyama, M., Nomura, T. & Takeda, M. Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-fiber pathway. Urology 70, 826\u2013831 (2007).","journal-title":"Urology"},{"key":"428_CR153","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.cub.2011.01.031","volume":"21","author":"W Everaerts","year":"2011","unstructured":"Everaerts, W. et al. The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Curr. Biol. 21, 316\u2013321 (2011).","journal-title":"Curr. Biol."},{"key":"428_CR154","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1002\/nau.22449","volume":"33","author":"T Minagawa","year":"2014","unstructured":"Minagawa, T., Aizawa, N., Igawa, Y. & Wyndaele, J.-J. The role of transient receptor potential ankyrin 1 (TRPA1) channel in activation of single unit mechanosensitive bladder afferent activities in the rat. Neurourol. Urodyn. 33, 544\u2013549 (2014).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR155","doi-asserted-by":"publisher","first-page":"13525","DOI":"10.1073\/pnas.0705924104","volume":"104","author":"CR McNamara","year":"2007","unstructured":"McNamara, C. R. et al. TRPA1 mediates formalin-induced pain. Proc. Natl Acad. Sci. USA 104, 13525\u201313530 (2007).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"428_CR156","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-4-48","volume":"4","author":"SR Eid","year":"2008","unstructured":"Eid, S. R. et al. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol. Pain 4, 48 (2008).","journal-title":"Mol. Pain"},{"key":"428_CR157","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33967-x","volume":"8","author":"J Kamei","year":"2018","unstructured":"Kamei, J. et al. Attenuated lipopolysaccharide-induced inflammatory bladder hypersensitivity in mice deficient of transient receptor potential ankilin1. Sci. Rep. 8, 15622 (2018).","journal-title":"Sci. Rep."},{"key":"428_CR158","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.eururo.2015.03.037","volume":"68","author":"P Uvin","year":"2015","unstructured":"Uvin, P. et al. Essential role of transient receptor potential M8 (TRPM8) in a model of acute cold-induced urinary urgency. Eur. Urol. 68, 655\u2013661 (2015).","journal-title":"Eur. Urol."},{"key":"428_CR159","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/nature719","volume":"416","author":"DD McKemy","year":"2002","unstructured":"McKemy, D. D., Neuhausser, W. M. & Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416, 52\u201358 (2002).","journal-title":"Nature"},{"key":"428_CR160","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1002\/cne.20794","volume":"493","author":"K Kobayashi","year":"2005","unstructured":"Kobayashi, K. et al. Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with a\u03b4\/c-fibers and colocalization with trk receptors. J. Comp. Neurol. 493, 596\u2013606 (2005).","journal-title":"J. Comp. Neurol."},{"key":"428_CR161","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1523\/JNEUROSCI.3976-07.2008","volume":"28","author":"A Dhaka","year":"2008","unstructured":"Dhaka, A., Earley, T. J., Watson, J. & Patapoutian, A. Visualizing cold spots: TRPM8-expressing sensory neurons and their projections. J. Neurosci. 28, 566\u2013575 (2008).","journal-title":"J. Neurosci."},{"key":"428_CR162","first-page":"3760","volume":"61","author":"L Tsavaler","year":"2001","unstructured":"Tsavaler, L., Shapero, M. H., Morkowski, S. & Laus, R. Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res. 61, 3760\u20133769 (2001).","journal-title":"Cancer Res."},{"key":"428_CR163","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1093\/jmcb\/mjs001","volume":"4","author":"S Ma","year":"2012","unstructured":"Ma, S. et al. Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity. J. Mol. Cell Biol. 4, 88\u201396 (2012).","journal-title":"J. Mol. Cell Biol."},{"key":"428_CR164","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nature05910","volume":"448","author":"DM Bautista","year":"2007","unstructured":"Bautista, D. M. et al. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448, 204\u2013208 (2007).","journal-title":"Nature"},{"key":"428_CR165","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.neuron.2007.02.024","volume":"54","author":"A Dhaka","year":"2007","unstructured":"Dhaka, A. et al. TRPM8 is required for cold sensation in mice. Neuron 54, 371\u2013378 (2007).","journal-title":"Neuron"},{"key":"428_CR166","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.neuron.2007.04.017","volume":"54","author":"RW Colburn","year":"2007","unstructured":"Colburn, R. W. et al. Attenuated cold sensitivity in TRPM8 null mice. Neuron 54, 379\u2013386 (2007).","journal-title":"Neuron"},{"key":"428_CR167","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.mce.2013.12.005","volume":"383","author":"M Rossato","year":"2014","unstructured":"Rossato, M. et al. Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production. Mol. Cell. Endocrinol. 383, 137\u2013146 (2014).","journal-title":"Mol. Cell. Endocrinol."},{"key":"428_CR168","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-8-36","volume":"8","author":"NR Gavva","year":"2012","unstructured":"Gavva, N. R. et al. Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulation. Mol. Pain 8, 36 (2012).","journal-title":"Mol. Pain"},{"key":"428_CR169","doi-asserted-by":"publisher","first-page":"F803","DOI":"10.1152\/ajprenal.90269.2008","volume":"295","author":"ESR Lashinger","year":"2008","unstructured":"Lashinger, E. S. R. et al. AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am. J. Physiol. Physiol. 295, F803\u2013F810 (2008).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR170","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1021\/ml500479v","volume":"6","author":"MD Andrews","year":"2015","unstructured":"Andrews, M. D. et al. Discovery of a selective TRPM8 antagonist with clinical efficacy in cold-related pain. ACS Med. Chem. Lett. 6, 419\u2013424 (2015).","journal-title":"ACS Med. Chem. Lett."},{"key":"428_CR171","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.bmc.2016.11.049","volume":"25","author":"J Kobayashi","year":"2017","unstructured":"Kobayashi, J. et al. Synthesis and optimization of novel \u03b1-phenylglycinamides as selective TRPM8 antagonists. Bioorg. Med. Chem. 25, 727\u2013742 (2017).","journal-title":"Bioorg. Med. Chem."},{"key":"428_CR172","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.lfs.2018.12.031","volume":"218","author":"N Aizawa","year":"2019","unstructured":"Aizawa, N. et al. RQ-00434739, a novel TRPM8 antagonist, inhibits prostaglandin E2-induced hyperactivity of the primary bladder afferent nerves in rats. Life Sci. 218, 89\u201395 (2019).","journal-title":"Life Sci."},{"key":"428_CR173","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.ejphar.2014.07.022","volume":"740","author":"JC Gardiner","year":"2014","unstructured":"Gardiner, J. C. et al. The role of TRPM8 in the guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist. Eur. J. Pharmacol. 740, 398\u2013409 (2014).","journal-title":"Eur. J. Pharmacol."},{"key":"428_CR174","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neures.2009.07.005","volume":"65","author":"T Hayashi","year":"2009","unstructured":"Hayashi, T. et al. Expression of the TRPM8-immunoreactivity in dorsal root ganglion neurons innervating the rat urinary bladder. Neurosci. Res. 65, 245\u2013251 (2009).","journal-title":"Neurosci. Res."},{"key":"428_CR175","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/bju.13225","volume":"117","author":"H Ito","year":"2016","unstructured":"Ito, H. et al. Functional role of the transient receptor potential melastatin 8 (TRPM8) ion channel in the urinary bladder assessed by conscious cystometry and ex vivo measurements of single-unit mechanosensitive bladder afferent activities in the rat. BJU Int. 117, 484\u2013494 (2016).","journal-title":"BJU Int."},{"key":"428_CR176","doi-asserted-by":"publisher","first-page":"69","DOI":"10.5213\/inj.2012.16.2.69","volume":"16","author":"JH Jun","year":"2012","unstructured":"Jun, J. H. et al. Function of the cold receptor (TRPM8) associated with voiding dysfunction in bladder outlet obstruction in rats. Int. Neurourol. J. 16, 69\u201376 (2012).","journal-title":"Int. Neurourol. J."},{"key":"428_CR177","doi-asserted-by":"publisher","first-page":"939","DOI":"10.3390\/cells3040939","volume":"3","author":"A Dietrich","year":"2014","unstructured":"Dietrich, A., Fahlbusch, M. & Gudermann, T. Classical transient receptor potential 1 (TRPC1): channel or channel regulator? Cells 3, 939\u2013962 (2014).","journal-title":"Cells"},{"key":"428_CR178","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00424-013-1332-y","volume":"466","author":"J Kim","year":"2014","unstructured":"Kim, J. et al. Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1\/4 channels. Pflugers Arch. 466, 491\u2013504 (2014).","journal-title":"Pflugers Arch."},{"key":"428_CR179","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1074\/jbc.M111.283218","volume":"287","author":"U Storch","year":"2012","unstructured":"Storch, U. et al. Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes. J. Biol. Chem. 287, 3530\u20133540 (2012).","journal-title":"J. Biol. Chem."},{"key":"428_CR180","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0896-6273(01)00240-9","volume":"29","author":"C Str\u00fcbing","year":"2001","unstructured":"Str\u00fcbing, C., Krapivinsky, G., Krapivinsky, L. & Clapham, D. E. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29, 645\u2013655 (2001).","journal-title":"Neuron"},{"key":"428_CR181","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/35055019","volume":"3","author":"M Freichel","year":"2001","unstructured":"Freichel, M. et al. Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4\u2212\/\u2212 mice. Nat. Cell Biol. 3, 121\u2013127 (2001).","journal-title":"Nat. Cell Biol."},{"key":"428_CR182","doi-asserted-by":"publisher","first-page":"39014","DOI":"10.1074\/jbc.M306705200","volume":"278","author":"C Str\u00fcbing","year":"2003","unstructured":"Str\u00fcbing, C., Krapivinsky, G., Krapivinsky, L. & Clapham, D. E. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J. Biol. Chem. 278, 39014\u201339019 (2003).","journal-title":"J. Biol. Chem."},{"key":"428_CR183","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1053\/j.gastro.2009.06.046","volume":"137","author":"VV Tsvilovskyy","year":"2009","unstructured":"Tsvilovskyy, V. V. et al. Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology 137, 1415\u20131424 (2009).","journal-title":"Gastroenterology"},{"key":"428_CR184","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1124\/mol.111.075341","volume":"81","author":"KD Phelan","year":"2012","unstructured":"Phelan, K. D. et al. Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Mol. Pharmacol. 81, 384\u201392 (2012).","journal-title":"Mol. Pharmacol."},{"key":"428_CR185","doi-asserted-by":"publisher","first-page":"5737","DOI":"10.1523\/JNEUROSCI.3753-11.2012","volume":"32","author":"O Stroh","year":"2012","unstructured":"Stroh, O. et al. NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells. J. Neurosci. 32, 5737\u20135746 (2012).","journal-title":"J. Neurosci."},{"key":"428_CR186","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069550","volume":"8","author":"M Boudes","year":"2013","unstructured":"Boudes, M. et al. Crucial role of TRPC1 and TRPC4 in cystitis-induced neuronal sprouting and bladder overactivity. PLoS One 8, e69550 (2013).","journal-title":"PLoS One"},{"key":"428_CR187","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.cell.2009.03.039","volume":"137","author":"A Riccio","year":"2009","unstructured":"Riccio, A. et al. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell 137, 761\u2013772 (2009).","journal-title":"Cell"},{"key":"428_CR188","doi-asserted-by":"publisher","first-page":"30813","DOI":"10.1074\/jbc.M305127200","volume":"278","author":"B Nilius","year":"2003","unstructured":"Nilius, B. et al. Voltage dependence of the Ca2+-activated cation channel TRPM4. J. Biol. Chem. 278, 30813\u201330820 (2003).","journal-title":"J. Biol. Chem."},{"key":"428_CR189","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1126\/science.1098845","volume":"306","author":"P Launay","year":"2004","unstructured":"Launay, P. et al. TRPM4 regulates calcium oscillations after T cell activation. Science 306, 1374\u20131377 (2004).","journal-title":"Science"},{"key":"428_CR190","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/ni1441","volume":"8","author":"R Vennekens","year":"2007","unstructured":"Vennekens, R. et al. Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat. Immunol. 8, 312\u2013320 (2007).","journal-title":"Nat. Immunol."},{"key":"428_CR191","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1038\/ni.1648","volume":"9","author":"G Barbet","year":"2008","unstructured":"Barbet, G. et al. The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells. Nat. Immunol. 9, 1148\u20131156 (2008).","journal-title":"Nat. Immunol."},{"key":"428_CR192","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nm.1899","volume":"15","author":"V Gerzanich","year":"2009","unstructured":"Gerzanich, V. et al. De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat. Med. 15, 185\u2013191 (2009).","journal-title":"Nat. Med."},{"key":"428_CR193","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1038\/nm.3015","volume":"18","author":"B Schattling","year":"2012","unstructured":"Schattling, B. et al. TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat. Med. 18, 1805\u20131811 (2012).","journal-title":"Nat. Med."},{"key":"428_CR194","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1016\/j.hrthm.2013.08.014","volume":"10","author":"T Hof","year":"2013","unstructured":"Hof, T., Simard, C., Rouet, R., Sall\u00e9, L. & Guinamard, R. Implication of the TRPM4 nonselective cation channel in mammalian sinus rhythm. Heart Rhythm. 10, 1683\u20131689 (2013).","journal-title":"Heart Rhythm."},{"key":"428_CR195","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.yjmcc.2013.01.019","volume":"59","author":"C Simard","year":"2013","unstructured":"Simard, C., Hof, T., Keddache, Z., Launay, P. & Guinamard, R. The TRPM4 non-selective cation channel contributes to the mammalian atrial action potential. J. Mol. Cell. Cardiol. 59, 11\u201319 (2013).","journal-title":"J. Mol. Cell. Cardiol."},{"key":"428_CR196","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.1172\/JCI41348","volume":"120","author":"I Mathar","year":"2010","unstructured":"Mathar, I. et al. Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. J. Clin. Invest. 120, 3267\u20133279 (2010).","journal-title":"J. Clin. Invest."},{"key":"428_CR197","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1161\/01.CIR.91.6.1633","volume":"91","author":"PA Brink","year":"1995","unstructured":"Brink, P. A. et al. Gene for progressive familial heart block type I maps to chromosome 19q13. Circulation 91, 1633\u20131640 (1995).","journal-title":"Circulation"},{"key":"428_CR198","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1161\/CIRCGENETICS.109.930867","volume":"3","author":"H Liu","year":"2010","unstructured":"Liu, H. et al. Gain-of-function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease. Circ. Cardiovasc. Genet. 3, 374\u2013385 (2010).","journal-title":"Circ. Cardiovasc. Genet."},{"key":"428_CR199","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.jid.2018.10.044","volume":"139","author":"H Wang","year":"2019","unstructured":"Wang, H. et al. Gain-of-function mutations in TRPM4 activation gate cause progressive symmetric erythrokeratodermia. J. Invest. Dermatol. 139, 1089\u20131097 (2019).","journal-title":"J. Invest. Dermatol."},{"key":"428_CR200","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1152\/ajpcell.00169.2012","volume":"304","author":"AC Smith","year":"2013","unstructured":"Smith, A. C. et al. Novel role for the transient potential receptor melastatin 4 channel in guinea pig detrusor smooth muscle physiology. Am. J. Physiol. Cell Physiol. 304, 467\u2013477 (2013).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"428_CR201","doi-asserted-by":"publisher","first-page":"C600","DOI":"10.1152\/ajpcell.00270.2015","volume":"310","author":"KL Hristov","year":"2016","unstructured":"Hristov, K. L. et al. Novel regulatory mechanism in human urinary bladder: central role of transient receptor potential melastatin 4 channels in detrusor smooth muscle function. Am. J. Physiol. Physiol. 310, C600\u2013C611 (2016).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR202","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1007\/s00210-018-1542-0","volume":"391","author":"FA Kullmann","year":"2018","unstructured":"Kullmann, F. A. et al. Involvement of TRPM4 in detrusor overactivity following spinal cord transection in mice. Naunyn Schmiedebergs Arch. Pharmacol. 391, 1191\u20131202 (2018).","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"428_CR203","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1111\/bph.12582","volume":"171","author":"R Guinamard","year":"2014","unstructured":"Guinamard, R., Hof, T. & Del Negro, C. A. The TRPM4 channel inhibitor 9-phenanthrol. Br. J. Pharmacol. 171, 1600\u20131613 (2014).","journal-title":"Br. J. Pharmacol."},{"key":"428_CR204","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1038\/bjp.2008.38","volume":"153","author":"T Grand","year":"2008","unstructured":"Grand, T. et al. 9-Phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br. J. Pharmacol. 153, 1697\u20131705 (2008).","journal-title":"Br. J. Pharmacol."},{"key":"428_CR205","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1111\/bph.13077","volume":"172","author":"SK Burris","year":"2015","unstructured":"Burris, S. K., Wang, Q., Bulley, S., Neeb, Z. P. & Jaggar, J. H. 9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels. Br. J. Pharmacol. 172, 2459\u20132468 (2015).","journal-title":"Br. J. Pharmacol."},{"key":"428_CR206","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1111\/bph.12985","volume":"172","author":"CJ Garland","year":"2015","unstructured":"Garland, C. J. et al. TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium-activated potassium channels in rat isolated mesenteric artery. Br. J. Pharmacol. 172, 1114\u20131123 (2015).","journal-title":"Br. J. Pharmacol."},{"key":"428_CR207","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12561-7","volume":"7","author":"H Lee","year":"2017","unstructured":"Lee, H. et al. Premature contractions of the bladder are suppressed by interactions between TRPV4 and SK3 channels in murine detrusor PDGFR\u03b1+ cells. Sci. Rep. 7, 12245 (2017).","journal-title":"Sci. Rep."},{"key":"428_CR208","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1111\/j.1582-4934.2011.01506.x","volume":"16","author":"BH Koh","year":"2012","unstructured":"Koh, B. H. et al. Platelet-derived growth factor receptor-a cells in mouse urinary bladder: a new class of interstitial cells. J. Cell Mol. Med. 16, 691\u2013700 (2012).","journal-title":"J. Cell Mol. Med."},{"key":"428_CR209","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1016\/j.juro.2016.05.108","volume":"196","author":"CS Griffin","year":"2016","unstructured":"Griffin, C. S. et al. Muscarinic receptor induced contractions of the detrusor are mediated by activation of TRPC4 channels. J. Urol. 196, 1796\u20131808 (2016).","journal-title":"J. Urol."},{"key":"428_CR210","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27617-5","volume":"8","author":"CS Griffin","year":"2018","unstructured":"Griffin, C. S., Thornbury, K. D., Hollywood, M. A. & Sergeant, G. P. Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice. Sci. Rep. 8, 9264 (2018).","journal-title":"Sci. Rep."},{"key":"428_CR211","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-921","volume":"14","author":"MB Morelli","year":"2014","unstructured":"Morelli, M. B. et al. Cross-talk between alpha 1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation. BMC Cancer 14, 921 (2014).","journal-title":"BMC Cancer"},{"key":"428_CR212","doi-asserted-by":"publisher","first-page":"19461","DOI":"10.1074\/jbc.M009895200","volume":"276","author":"U Wissenbach","year":"2001","unstructured":"Wissenbach, U. et al. Expression of CaT-like, a novel calcium-selective channel, correlates with the malignancy of prostate cancer. J. Biol. Chem. 276, 19461\u201319468 (2001).","journal-title":"J. Biol. Chem."},{"key":"428_CR213","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1002\/jcp.27371","volume":"234","author":"AI Sagredo","year":"2019","unstructured":"Sagredo, A. I. et al. TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines. J. Cell. Physiol. 234, 2037\u20132050 (2019).","journal-title":"J. Cell. Physiol."},{"key":"428_CR214","doi-asserted-by":"publisher","first-page":"41783","DOI":"10.18632\/oncotarget.6157","volume":"6","author":"C Holzmann","year":"2015","unstructured":"Holzmann, C. et al. Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells. Oncotarget 6, 41783\u201341793 (2015).","journal-title":"Oncotarget"},{"key":"428_CR215","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12032-017-0987-1","volume":"34","author":"L Chen","year":"2017","unstructured":"Chen, L. et al. Downregulation of TRPM7 suppressed migration and invasion by regulating epithelial\u2013mesenchymal transition in prostate cancer cells. Med. Oncol. 34, 1\u201311 (2017).","journal-title":"Med. Oncol."},{"key":"428_CR216","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3390\/ph9030044","volume":"9","author":"G Grolez","year":"2016","unstructured":"Grolez, G. & Gkika, D. TRPM8 puts the chill on prostate cancer. Pharmaceuticals 9, 44 (2016).","journal-title":"Pharmaceuticals"},{"key":"428_CR217","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1158\/0008-5472.CAN-05-0376","volume":"66","author":"S Thebault","year":"2006","unstructured":"Thebault, S. et al. Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells. Cancer Res. 66, 2038\u20132047 (2006).","journal-title":"Cancer Res."},{"key":"428_CR218","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1111\/j.1745-7262.2007.00291.x","volume":"9","author":"HP Wang","year":"2007","unstructured":"Wang, H. P., Pu, X. Y. & Wang, X. H. Distribution profiles of transient receptor potential melastatin-related and vanilloid-related channels in prostatic tissue in rat. Asian J. Androl. 9, 634\u2013640 (2007).","journal-title":"Asian J. Androl."},{"key":"428_CR219","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","volume":"347","author":"M Uhlen","year":"2015","unstructured":"Uhlen, M. et al. Tissue-based map of the human proteome. Science. 347, 1260419\u20131260419 (2015).","journal-title":"Science."},{"key":"428_CR220","unstructured":"Human Protein Atlas. http:\/\/www.proteinatlas.org."},{"key":"428_CR221","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.eururo.2005.01.009","volume":"48","author":"P Dinis","year":"2005","unstructured":"Dinis, P. et al. The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate. Eur. Urol. 48, 162\u2013167 (2005).","journal-title":"Eur. Urol."},{"key":"428_CR222","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/pros.23913","volume":"80","author":"K Roman","year":"2020","unstructured":"Roman, K., Hall, C., Schaeffer, A. J. & Thumbikat, P. TRPV1 in experimental autoimmune prostatitis. Prostate 80, 28\u201337 (2020).","journal-title":"Prostate"},{"key":"428_CR223","doi-asserted-by":"publisher","DOI":"10.1111\/and.13302","volume":"51","author":"J Zhang","year":"2019","unstructured":"Zhang, J. et al. Upregulation of TRPV1 in spinal dorsal root ganglion by activating NGF-TrkA pathway contributes to pelvic organ cross-sensitisation in rats with experimental autoimmune prostatitis. Andrologia 51, e13302 (2019).","journal-title":"Andrologia"},{"key":"428_CR224","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1113\/JP277452","volume":"597","author":"Y Funahashi","year":"2019","unstructured":"Funahashi, Y. et al. Bladder overactivity and afferent hyperexcitability induced by prostate-to-bladder cross-sensitization in rats with prostatic inflammation. J. Physiol. 597, 2063\u20132078 (2019).","journal-title":"J. Physiol."},{"key":"428_CR225","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/ar.23937","volume":"302","author":"M Eggermont","year":"2019","unstructured":"Eggermont, M., De Wachter, S., Eastham, J. & Gillespie, J. Innervation of the epithelium and lamina propria of the urethra of the female rat. Anat. Rec. 302, 201\u2013214 (2019).","journal-title":"Anat. Rec."},{"key":"428_CR226","doi-asserted-by":"publisher","first-page":"5687","DOI":"10.1113\/JP274191","volume":"595","author":"ZC Danziger","year":"2017","unstructured":"Danziger, Z. C. & Grill, W. M. Sensory feedback from the urethra evokes state-dependent lower urinary tract reflexes in rat. J. Physiol. 595, 5687\u20135698 (2017).","journal-title":"J. Physiol."},{"key":"428_CR227","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1124\/jpet.107.125435","volume":"323","author":"L Birder","year":"2007","unstructured":"Birder, L. et al. Activation of urothelial transient receptor potential vanilloid 4 by 4-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. J. Pharmacol. Exp. Ther. 323, 227\u2013235 (2007).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"428_CR228","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1002\/nau.23990","volume":"38","author":"MG Oliveira","year":"2019","unstructured":"Oliveira, M. G. et al. Autonomic dysregulation at multiple sites is implicated in age-associated underactive bladder in female mice. Neurourol. Urodyn. 38, 1212\u20131221 (2019).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR229","doi-asserted-by":"publisher","first-page":"8782","DOI":"10.1074\/jbc.M111.308411","volume":"287","author":"J Berrout","year":"2012","unstructured":"Berrout, J. et al. Function of transient receptor potential cation channel subfamily V member 4 (TRPV4) as a mechanical transducer in flow-sensitive segments of renal collecting duct system. J. Biol. Chem. 287, 8782\u20138791 (2012).","journal-title":"J. Biol. Chem."},{"key":"428_CR230","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1111\/j.1476-5381.1993.tb13911.x","volume":"110","author":"M Parlani","year":"1993","unstructured":"Parlani, M., Conte, B., Goso, C., Szallasi, A. & Manzini, S. Capsaicin-induced relaxation in the rat isolated external urethral sphincter: characterization of the vanilloid receptor and mediation by CGRP. Br. J. Pharmacol. 110, 989\u2013994 (1993).","journal-title":"Br. J. Pharmacol."},{"key":"428_CR231","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1016\/j.juro.2009.12.093","volume":"183","author":"P Weinhold","year":"2010","unstructured":"Weinhold, P. et al. TRPA1 receptor induced relaxation of the human urethra involves TRPV1 and cannabinoid receptor mediated signals, and cyclooxygenase activation. J. Urol. 183, 2070\u20132076 (2010).","journal-title":"J. Urol."},{"key":"428_CR232","doi-asserted-by":"publisher","first-page":"8287","DOI":"10.1073\/pnas.1402436111","volume":"111","author":"K Deckmann","year":"2014","unstructured":"Deckmann, K. et al. Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes. Proc. Natl Acad. Sci. USA 111, 8287\u20138292 (2014).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"428_CR233","doi-asserted-by":"publisher","first-page":"3210","DOI":"10.1073\/pnas.0911934107","volume":"107","author":"M Tizzano","year":"2010","unstructured":"Tizzano, M. et al. Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals. Proc. Natl Acad. Sci. USA 107, 3210\u20133215 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"428_CR234","doi-asserted-by":"publisher","first-page":"9478","DOI":"10.1073\/pnas.1019418108","volume":"108","author":"G Krasteva","year":"2011","unstructured":"Krasteva, G. et al. Cholinergic chemosensory cells in the trachea regulate breathing. Proc. Natl Acad. Sci. USA 108, 9478\u20139483 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"428_CR235","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/978-3-642-54215-2_19","volume":"222","author":"ER Liman","year":"2014","unstructured":"Liman, E. R. TRPM5. Handb. Exp. Pharmacol. 222, 489\u2013502 (2014).","journal-title":"Handb. Exp. Pharmacol."},{"key":"428_CR236","doi-asserted-by":"publisher","first-page":"F1146","DOI":"10.1152\/ajprenal.00592.2007","volume":"294","author":"Y Yu","year":"2008","unstructured":"Yu, Y. & de Groat, W. C. Sensitization of pelvic afferent nerves in the in vitro rat urinary bladder-pelvic nerve preparation by purinergic agonists and cyclophosphamide pretreatment. Am. J. Physiol. Physiol. 294, F1146\u2013F1156 (2008).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR237","doi-asserted-by":"publisher","first-page":"e66","DOI":"10.1038\/emm.2013.97","volume":"45","author":"BS Park","year":"2013","unstructured":"Park, B. S. & Lee, J.-O. Recognition of lipopolysaccharide pattern by TLR4 complexes. Exp. Mol. Med. 45, e66\u2013e66 (2013).","journal-title":"Exp. Mol. Med."},{"key":"428_CR238","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01201-3","volume":"8","author":"YA Alpizar","year":"2017","unstructured":"Alpizar, Y. A. et al. TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells. Nat. Commun. 8, 1059 (2017).","journal-title":"Nat. Commun."},{"key":"428_CR239","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.juro.2006.11.046","volume":"177","author":"A Charrua","year":"2007","unstructured":"Charrua, A., Cruz, C. D., Cruz, F. & Avelino, A. Transient receptor potential vanilloid subfamily 1 is essential for the generation of noxious bladder input and bladder overactivity in cystitis. J. Urol. 177, 1537\u20131541 (2007).","journal-title":"J. Urol."},{"key":"428_CR240","doi-asserted-by":"publisher","first-page":"R1027","DOI":"10.1152\/ajpregu.2000.278.4.R1027","volume":"278","author":"MA Vizzard","year":"2000","unstructured":"Vizzard, M. A. Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitis. Am. J. Physiol. Integr. Comp. Physiol. 278, R1027\u2013R1039 (2000).","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"428_CR241","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0301-0082(96)00021-4","volume":"50","author":"DG Herrera","year":"1996","unstructured":"Herrera, D. G. & Robertson, H. A. Activation of c-fos in the brain. Prog. Neurobiol. 50, 83\u2013107 (1996).","journal-title":"Prog. Neurobiol."},{"key":"428_CR242","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0361-9230(97)00277-3","volume":"45","author":"JA Harris","year":"1998","unstructured":"Harris, J. A. Using c-fos as a neural marker of pain. Brain Res. Bull. 45, 1\u20138 (1998).","journal-title":"Brain Res. Bull."},{"key":"428_CR243","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1016\/0006-2952(79)90222-3","volume":"28","author":"PJ Cox","year":"1979","unstructured":"Cox, P. J. Cyclophosphamide cystitis \u2014 identification of acrolein as the causative agent. Biochem. Pharmacol. 28, 2045\u20132049 (1979).","journal-title":"Biochem. Pharmacol."},{"key":"428_CR244","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1002\/nau.23532","volume":"37","author":"N Aizawa","year":"2018","unstructured":"Aizawa, N. et al. KPR-2579, a novel TRPM8 antagonist, inhibits acetic acid-induced bladder afferent hyperactivity in rats. Neurourol. Urodyn. 37, 1633\u20131640 (2018).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR245","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1080\/00365590902808566","volume":"43","author":"K Franz\u00e9n","year":"2009","unstructured":"Franz\u00e9n, K., Johansson, J.-E., Andersson, G., Pettersson, N. & Nilsson, K. Urinary incontinence in women is not exclusively a medical problem: A population-based study on urinary incontinence and general living conditions. Scand. J. Urol. Nephrol. 43, 226\u2013232 (2009).","journal-title":"Scand. J. Urol. Nephrol."},{"key":"428_CR246","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/S0090-4295(00)00988-2","volume":"57","author":"NE Rothrock","year":"2001","unstructured":"Rothrock, N. E., Lutgendorf, S. K., Kreder, K. J., Ratliff, T. & Zimmerman, B. Stress and symptoms in patients with interstitial cystitis: a life stress model. Urology 57, 422\u2013427 (2001).","journal-title":"Urology"},{"key":"428_CR247","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/nrurol.2010.203","volume":"8","author":"RJ Valentino","year":"2011","unstructured":"Valentino, R. J., Wood, S. K., Wein, A. J. & Zderic, S. A. The bladder\u2013brain connection: putative role of corticotropin-releasing factor. Nat. Rev. Urol. 8, 19\u201328 (2011).","journal-title":"Nat. Rev. Urol."},{"key":"428_CR248","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.urology.2012.04.077","volume":"80","author":"C Wolfe-Christensen","year":"2012","unstructured":"Wolfe-Christensen, C., Veenstra, A. L., Kovacevic, L., Elder, J. S. & Lakshmanan, Y. Psychosocial difficulties in children referred to pediatric urology: a closer look. Urology 80, 907\u2013913 (2012).","journal-title":"Urology"},{"key":"428_CR249","doi-asserted-by":"publisher","first-page":"R893","DOI":"10.1152\/ajpregu.00500.2013","volume":"307","author":"GC Mingin","year":"2014","unstructured":"Mingin, G. C., Peterson, A., Erickson, C. S., Nelson, M. T. & Vizzard, M. A. Social stress induces changes in urinary bladder function, bladder NGF content, and generalized bladder inflammation in mice. Am. J. Physiol. Integr. Comp. Physiol. 307, R893\u2013R900 (2014).","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"428_CR250","doi-asserted-by":"publisher","first-page":"R629","DOI":"10.1152\/ajpregu.00013.2015","volume":"309","author":"GC Mingin","year":"2015","unstructured":"Mingin, G. C. et al. Social stress in mice induces urinary bladder overactivity and increases TRPV1 channel-dependent afferent nerve activity. Am. J. Physiol. Integr. Comp. Physiol. 309, R629\u2013R638 (2015).","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"428_CR251","doi-asserted-by":"publisher","first-page":"F1583","DOI":"10.1152\/ajprenal.00231.2018","volume":"315","author":"NR Tykocki","year":"2018","unstructured":"Tykocki, N. R. et al. Development of stress-induced bladder insufficiency requires functional TRPV1 channels. Am. J. Physiol. Physiol. 315, F1583\u2013F1591 (2018).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR252","doi-asserted-by":"publisher","first-page":"R1671","DOI":"10.1152\/ajpregu.91013.2008","volume":"296","author":"SK Wood","year":"2009","unstructured":"Wood, S. K., Baez, M. A., Bhatnagar, S. & Valentino, R. J. Social stress-induced bladder dysfunction: potential role of corticotropin-releasing factor. Am. J. Physiol. Integr. Comp. Physiol. 296, R1671\u2013R1678 (2009).","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"428_CR253","doi-asserted-by":"publisher","first-page":"R471","DOI":"10.1152\/ajpregu.00008.2014","volume":"307","author":"L Merrill","year":"2014","unstructured":"Merrill, L. & Vizzard, M. A. Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 307, R471\u2013R480 (2014).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"428_CR254","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(87)90263-0","volume":"415","author":"CA Maggi","year":"1987","unstructured":"Maggi, C. A. et al. The contribution of capsaicin-sensitive innervation to activation of the spinal vesico-vesical reflex in rats: relationship between substance P levels in the urinary bladder and the sensory-efferent function of capsaicin-sensitive sensory neurons. Brain Res. 415, 1\u201313 (1987).","journal-title":"Brain Res."},{"key":"428_CR255","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1016\/0165-1838(90)90105-R","volume":"30","author":"WC de Groat","year":"1990","unstructured":"de Groat, W. C. et al. Mechanisms underlying the recovery of urinary bladder function following spinal cord injury. J. Auton. Nerv. Syst. 30, S71\u2013S77 (1990).","journal-title":"J. Auton. Nerv. Syst."},{"key":"428_CR256","doi-asserted-by":"publisher","first-page":"8947","DOI":"10.1523\/JNEUROSCI.18-21-08947.1998","volume":"18","author":"DA Simone","year":"1998","unstructured":"Simone, D. A., Nolano, M., Johnson, T., Wendelschafer-Crabb, G. & Kennedy, W. R. Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: correlation with sensory function. J. Neurosci. 18, 8947\u20138959 (1998).","journal-title":"J. Neurosci."},{"key":"428_CR257","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/nau.23314","volume":"37","author":"V Ph\u00e9","year":"2018","unstructured":"Ph\u00e9, V. et al. Intravesical vanilloids for treating neurogenic lower urinary tract dysfunction in patients with multiple sclerosis: a systematic review and meta-analysis. A report from the Neuro-Urology Promotion Committee of the International Continence Society (ICS). Neurourol. Urodyn. 37, 67\u201382 (2018).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR258","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/0304-3959(94)00193-I","volume":"61","author":"RM Craft","year":"1995","unstructured":"Craft, R. M., Cohen, S. M. & Porreca, F. Long-lasting desensitization of bladder afferents following intravesical resiniferatoxin and capsaicin in the rat. Pain 61, 317\u2013323 (1995).","journal-title":"Pain"},{"key":"428_CR259","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1159\/000020004","volume":"36","author":"M de S\u00e8ze","year":"1999","unstructured":"de S\u00e8ze, M. et al. Intravesical instillation of capsaicin in urology: a review of the literature. Eur. Urol. 36, 267\u201377 (1999).","journal-title":"Eur. Urol."},{"key":"428_CR260","doi-asserted-by":"publisher","first-page":"F1223","DOI":"10.1152\/ajprenal.00535.2010","volume":"300","author":"EL Andrade","year":"2011","unstructured":"Andrade, E. L. et al. TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury. Am. J. Physiol. Physiol. 300, F1223\u2013F1234 (2011).","journal-title":"Am. J. Physiol. Physiol."},{"key":"428_CR261","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrurol.2014.286","volume":"11","author":"NI Osman","year":"2014","unstructured":"Osman, N. I. & Chapple, C. R. Contemporary concepts in the aetiopathogenesis of detrusor underactivity. Nat. Rev. Urol. 11, 639\u2013648 (2014).","journal-title":"Nat. Rev. Urol."},{"key":"428_CR262","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0090-4295(02)02243-4","volume":"61","author":"P Abrams","year":"2003","unstructured":"Abrams, P. et al. The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society. Urology 61, 37\u201349 (2003).","journal-title":"Urology"},{"key":"428_CR263","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.eururo.2015.02.030","volume":"68","author":"CR Chapple","year":"2015","unstructured":"Chapple, C. R. et al. The underactive bladder: a new clinical concept? Eur. Urol. 68, 351\u2013353 (2015).","journal-title":"Eur. Urol."},{"key":"428_CR264","doi-asserted-by":"publisher","first-page":"185","DOI":"10.5213\/inj.2015.19.3.185","volume":"19","author":"N Hoag","year":"2015","unstructured":"Hoag, N. & Gani, J. Underactive bladder: clinical features, urodynamic parameters, and treatment. Int. Neurourol. J. 19, 185\u2013189 (2015).","journal-title":"Int. Neurourol. J."},{"key":"428_CR265","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1002\/nau.23790","volume":"37","author":"E Takaoka","year":"2018","unstructured":"Takaoka, E. et al. Effect of TRPV4 activation in a rat model of detrusor underactivity induced by bilateral pelvic nerve crush injury. Neurourol. Urodyn. 37, 2527\u20132534 (2018).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR266","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-6-31","volume":"6","author":"G Mukerji","year":"2006","unstructured":"Mukerji, G. et al. Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders. BMC Urol. 6, 31 (2006).","journal-title":"BMC Urol."},{"key":"428_CR267","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-6-6","volume":"6","author":"G Mukerji","year":"2006","unstructured":"Mukerji, G. et al. Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations. BMC Urol. 6, 6 (2006).","journal-title":"BMC Urol."},{"key":"428_CR268","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000355175","volume":"92","author":"B Liu","year":"2014","unstructured":"Liu, B. et al. Increased severity of inflammation correlates with elevated expression of TRPV1 nerve fibers and nerve growth factor on interstitial cystitis\/bladder pain syndrome. Urol. Int. 92, 202\u2013208 (2014).","journal-title":"Urol. Int."},{"key":"428_CR269","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/bph.12467","volume":"171","author":"FN Dornelles","year":"2014","unstructured":"Dornelles, F. N., Andrade, E. L., Campos, M. M. & Calixto, J. B. Role of CXCR2 and TRPV1 in functional, inflammatory and behavioural changes in the rat model of cyclophosphamide-induced haemorrhagic cystitis. Br. J. Pharmacol. 171, 452\u2013467 (2014).","journal-title":"Br. J. Pharmacol."},{"key":"428_CR270","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1464-4096.2004.04855.x","volume":"94","author":"P Dinis","year":"2004","unstructured":"Dinis, P., Charrua, A., Avelino, A. & Cruz, F. Intravesical resiniferatoxin decreases spinal c-fos expression and increases bladder volume to reflex micturition in rats with chronic inflamed urinary bladders. BJU Int. 94, 153\u2013157 (2004).","journal-title":"BJU Int."},{"key":"428_CR271","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/(SICI)1520-6777(1998)17:5<513::AID-NAU7>3.0.CO;2-G","volume":"17","author":"M de S\u00e8ze","year":"1998","unstructured":"de S\u00e8ze, M. et al. Capsaicin and neurogenic detrusor hyperreflexia: a double-blind placebo-controlled study in 20 patients with spinal cord lesions. Neurourol. Urodyn. 17, 513\u2013523 (1998).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR272","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/S0022-5347(05)67279-5","volume":"164","author":"M Lazzeri","year":"2000","unstructured":"Lazzeri, M. et al. Intravesical resiniferatoxin for the treatment of hypersensitive disorder: a randomized placebo controlled study. J. Urol. 164, 676\u2013679 (2000).","journal-title":"J. Urol."},{"key":"428_CR273","doi-asserted-by":"publisher","first-page":"41","DOI":"10.5213\/inj.2012.16.1.41","volume":"16","author":"BK Ham","year":"2012","unstructured":"Ham, B. K., Kim, J. H., Oh, M. M., Lee, J. G. & Bae, J. H. Effects of combination treatment of intravesical resiniferatoxin instillation and hydrodistention in patients with refractory painful bladder syndrome\/interstitial cystitis: a pilot study. Int. Neurourol. J. 16, 41\u201346 (2012).","journal-title":"Int. Neurourol. J."},{"key":"428_CR274","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1097\/01.ju.0000154631.92150.ef","volume":"173","author":"CK Payne","year":"2005","unstructured":"Payne, C. K. et al. Intravesical resiniferatoxin for the treatment of interstitial cystitis: a randomized, double-blind, placebo controlled trial. J. Urol. 173, 1590\u20131594 (2005).","journal-title":"J. Urol."},{"key":"428_CR275","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.cbi.2013.03.008","volume":"203","author":"FC Meotti","year":"2013","unstructured":"Meotti, F. C., Forner, S., Lima-Garcia, J. F., Viana, A. F. & Calixto, J. B. Antagonism of the transient receptor potential ankyrin 1 (TRPA1) attenuates hyperalgesia and urinary bladder overactivity in cyclophosphamide-induced haemorrhagic cystitis. Chem. Biol. Interact. 203, 440\u2013447 (2013).","journal-title":"Chem. Biol. Interact."},{"key":"428_CR276","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1016\/j.pain.2014.03.023","volume":"155","author":"JJ Deberry","year":"2014","unstructured":"Deberry, J. J., Schwartz, E. S. & Davis, B. M. TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis. Pain 155, 1280\u20131287 (2014).","journal-title":"Pain"},{"key":"428_CR277","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/S0090-4295(99)80332-X","volume":"49","author":"M Alagiri","year":"1997","unstructured":"Alagiri, M., Chottiner, S., Ratner, V., Slade, D. & Hanno, P. M. Interstitial cystitis: Unexplained associations with other chronic disease and pain syndromes. Urology 49, 52\u201357 (1997).","journal-title":"Urology"},{"key":"428_CR278","doi-asserted-by":"publisher","first-page":"G301","DOI":"10.1152\/ajpgi.00272.2017","volume":"314","author":"L Grundy","year":"2018","unstructured":"Grundy, L. & Brierley, S. M. Cross-organ sensitization between the colon and bladder: to pee or not to pee? Am. J. Physiol. Gastrointest. Liver Physiol. 314, G301\u2013G308 (2018).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"428_CR279","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.neuroscience.2007.07.053","volume":"149","author":"AP Malykhina","year":"2007","unstructured":"Malykhina, A. P. Neural mechanisms of pelvic organ cross-sensitization. Neuroscience 149, 660\u2013672 (2007).","journal-title":"Neuroscience"},{"key":"428_CR280","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1007\/s00192-014-2405-y","volume":"25","author":"A Furuta","year":"2014","unstructured":"Furuta, A. et al. Cross-sensitization mechanisms between colon and bladder via transient receptor potential A1 stimulation in rats. Int. Urogynecol. J. 25, 1575\u20131581 (2014).","journal-title":"Int. Urogynecol. J."},{"key":"428_CR281","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/S0022-5347(17)34984-4","volume":"151","author":"G Geirsson","year":"1994","unstructured":"Geirsson, G. et al. Positive bladder cooling test in neurologically normal young children. J. Urol. 151, 446\u2013448 (1994).","journal-title":"J. Urol."},{"key":"428_CR282","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1001\/archneurpsyc.1957.02330400013002","volume":"78","author":"EH Bors","year":"1957","unstructured":"Bors, E. H. & Blinn, K. A. Spinal reflex activity from the vesical mucosa in paraplegic patients. Arch. Neurol. Psychiatry 78, 339\u2013354 (1957).","journal-title":"Arch. Neurol. Psychiatry"},{"key":"428_CR283","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1046\/j.1464-410X.1997.00133.x","volume":"79","author":"G Ronzoni","year":"1997","unstructured":"Ronzoni, G., Menchinelli, P., Manca, A. & De Giovanni, L. The ice-water test in the diagnosis and treatment of the neurogenic bladder. Br. J. Urol. 79, 698\u2013701 (1997).","journal-title":"Br. J. Urol."},{"key":"428_CR284","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/S0022-5347(05)68062-7","volume":"162","author":"G Geirsson","year":"1999","unstructured":"Geirsson, G., Lindstr\u00f6m, S. & Fall, M. The bladder cooling reflex and the use of cooling as stimulus to the lower urinary tract. J. Urol. 162, 1890\u20131896 (1999).","journal-title":"J. Urol."},{"key":"428_CR285","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1124\/jpet.114.216010","volume":"351","author":"WJ Winchester","year":"2014","unstructured":"Winchester, W. J. et al. Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J. Pharmacol. Exp. Ther. 351, 259\u201369 (2014).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"428_CR286","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1111\/bju.13321","volume":"117","author":"W Everaerts","year":"2016","unstructured":"Everaerts, W. & De Ridder, D. TRPM8 antagonists to treat lower urinary tract symptoms: don\u2019t lose your cool just yet. BJU Int. 117, 384\u2013385 (2016).","journal-title":"BJU Int."},{"key":"428_CR287","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1097\/01.ju.0000170235.22776.1a","volume":"174","author":"M Ghei","year":"2005","unstructured":"Ghei, M. & Malone-Lee, J. Using the circumstances of symptom experience to assess the severity of urgency in the overactive bladder. J. Urol. 174, 972\u2013976 (2005).","journal-title":"J. Urol."},{"key":"428_CR288","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1002\/nau.20497","volume":"27","author":"T Imamura","year":"2008","unstructured":"Imamura, T. et al. Cold environmental stress induces detrusor overactivity via resiniferatoxin-sensitive nerves in conscious rats. Neurourol. Urodyn. 27, 348\u2013352 (2008).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR289","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/nau.1930110507","volume":"11","author":"A Kondo","year":"1992","unstructured":"Kondo, A. et al. Prevalence of hand-washing urinary incontinence in healthy subjects in relation to stress and urge incontinence. Neurourol. Urodyn. 11, 519\u2013523 (1992).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR290","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/iju.12129","volume":"20","author":"T Imamura","year":"2013","unstructured":"Imamura, T., Ishizuka, O. & Nishizawa, O. Cold stress induces lower urinary tract symptoms. Int. J. Urol. 20, 661\u2013669 (2013).","journal-title":"Int. J. Urol."},{"key":"428_CR291","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/WON.0b013e31824353f5","volume":"39","author":"E Victor","year":"2012","unstructured":"Victor, E., O\u2019Connell, K. A. & Blaivas, J. G. Environmental cues to urgency and leakage episodes in patients with overactive bladder syndrome: a pilot study. J. Wound Ostomy Cont. Nurs. 39, 181\u2013186 (2012).","journal-title":"J. Wound Ostomy Cont. Nurs."},{"key":"428_CR292","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1002\/nau.21092","volume":"30","author":"NR Zinner","year":"2011","unstructured":"Zinner, N. R. OAB. Are we barking up the wrong tree? A lesson from my dog. Neurourol. Urodyn. 30, 1410\u20131411 (2011).","journal-title":"Neurourol. Urodyn."},{"key":"428_CR293","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1038\/nn1525","volume":"8","author":"ES Boyden","year":"2005","unstructured":"Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G. & Deisseroth, K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat. Neurosci. 8, 1263\u20131268 (2005).","journal-title":"Nat. Neurosci."},{"key":"428_CR294","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nature08652","volume":"463","author":"BY Chow","year":"2010","unstructured":"Chow, B. Y. et al. High-performance genetically targetable optical neural silencing by light-driven proton pumps. Nature 463, 98\u2013102 (2010).","journal-title":"Nature"},{"key":"428_CR295","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16129-3","volume":"7","author":"VK Samineni","year":"2017","unstructured":"Samineni, V. K. et al. Optogenetic silencing of nociceptive primary afferents reduces evoked and ongoing bladder pain. Sci. Rep. 7, 15865 (2017).","journal-title":"Sci. Rep."},{"key":"428_CR296","doi-asserted-by":"publisher","DOI":"10.1038\/srep40872","volume":"7","author":"JH Park","year":"2016","unstructured":"Park, J. H. et al. Optogenetic modulation of urinary bladder contraction for lower urinary tract dysfunction. Sci. Rep. 7, 40872 (2016).","journal-title":"Sci. Rep."},{"key":"428_CR297","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1038\/s41593-018-0256-4","volume":"21","author":"J Yao","year":"2018","unstructured":"Yao, J. et al. A corticopontine circuit for initiation of urination. Nat. Neurosci. 21, 1541\u20131550 (2018).","journal-title":"Nat. Neurosci."},{"key":"428_CR298","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/s41586-018-0823-6","volume":"565","author":"AD Mickle","year":"2019","unstructured":"Mickle, A. D. et al. A wireless closed-loop system for optogenetic peripheral neuromodulation. Nature 565, 361\u2013365 (2019).","journal-title":"Nature"},{"key":"428_CR299","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fnint.2018.00005","volume":"12","author":"JJ DeBerry","year":"2018","unstructured":"DeBerry, J. J. et al. Differential regulation of bladder pain and voiding function by sensory afferent populations revealed by selective optogenetic activation. Front. Integr. Neurosci. 12, 5 (2018).","journal-title":"Front. Integr. Neurosci."},{"key":"428_CR300","doi-asserted-by":"crossref","unstructured":"Smith-Anttila, J. A. et al. Sensory and motor systems identification of a sacral, visceral sensory transcriptome in embryonic and adult mice. eNeuro 7, ENEURO.0397-19.2019 (2020).","DOI":"10.1523\/ENEURO.0397-19.2019"},{"key":"428_CR301","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1007\/s12031-013-0033-5","volume":"51","author":"BM Girard","year":"2013","unstructured":"Girard, B. M., Merrill, L., Malley, S. & Vizzard, M. A. Increased TRPV4 expression in urinary bladder and lumbosacral dorsal root ganglia in mice with chronic overexpression of NGF in urothelium. J. Mol. Neurosci. 51, 602\u2013614 (2013).","journal-title":"J. Mol. Neurosci."},{"key":"428_CR302","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.lfs.2017.10.042","volume":"193","author":"BR Sharopov","year":"2018","unstructured":"Sharopov, B. R., Gulak, K. L., Philyppov, I. B., Sotkis, A. V. & Shuba, Y. M. TRPV1 alterations in urinary bladder dysfunction in a rat model of STZ-induced diabetes. Life Sci. 193, 207\u2013213 (2018).","journal-title":"Life Sci."},{"key":"428_CR303","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.neulet.2018.06.049","volume":"683","author":"N Shimizu","year":"2018","unstructured":"Shimizu, N. et al. Effects of nerve growth factor neutralization on TRP channel expression in laser-captured bladder afferent neurons in mice with spinal cord injury. Neurosci. Lett. 683, 100\u2013103 (2018).","journal-title":"Neurosci. Lett."},{"key":"428_CR304","first-page":"61","volume":"156","author":"G Owsianik","year":"2006","unstructured":"Owsianik, G., D\u2019hoedt, D., Voets, T. & Nilius, B. Structure\u2013function relationship of the TRP channel superfamily. Rev. Physiol. Biochem. Pharmacol. 156, 61\u201390 (2006).","journal-title":"Rev. Physiol. Biochem. Pharmacol."}],"container-title":["Nature Reviews Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41585-021-00428-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41585-021-00428-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41585-021-00428-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T04:29:27Z","timestamp":1697776167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41585-021-00428-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,3]]},"references-count":304,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["428"],"URL":"https:\/\/doi.org\/10.1038\/s41585-021-00428-6","relation":{},"ISSN":["1759-4812","1759-4820"],"issn-type":[{"value":"1759-4812","type":"print"},{"value":"1759-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,3]]},"assertion":[{"value":"8 January 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}