{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:55:45Z","timestamp":1793300145785,"version":"4.5.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"7700","license":[{"start":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T00:00:00Z","timestamp":1522800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T00:00:00Z","timestamp":1522800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2018,4,12]]},"DOI":"10.1038\/s41586-018-0010-9","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T18:13:53Z","timestamp":1522347233000},"page":"255-258","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":670,"title":["Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin"],"prefix":"10.1038","volume":"556","author":[{"given":"Peng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Lou","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Feng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Mei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailendra","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Shuang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Man","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Qian","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ping","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Jie","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Xian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle E.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Biao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Qiang","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Tong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Ju","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Li-Lan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Zhen","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Shan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Daszak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Fa","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Li","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Gang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,4]]},"reference":[{"key":"10_CR1","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/nature22975","volume":"546","author":"KJ Olival","year":"2017","unstructured":"Olival, K. J. et al. Host and viral traits predict zoonotic spillover from mammals. Nature\n\t\t\t\t\t546, 646\u2013650 (2017).","journal-title":"Nature"},{"key":"10_CR2","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1126\/science.1087139","volume":"302","author":"Y Guan","year":"2003","unstructured":"Guan, Y. et al. Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China. Science\n\t\t\t\t\t302, 276\u2013278 (2003).","journal-title":"Science"},{"key":"10_CR3","doi-asserted-by":"publisher","first-page":"14040","DOI":"10.1073\/pnas.0506735102","volume":"102","author":"SK Lau","year":"2005","unstructured":"Lau, S. K. et al. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc. Natl Acad. Sci. USA\n\t\t\t\t\t102, 14040\u201314045 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10_CR4","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1126\/science.1118391","volume":"310","author":"W Li","year":"2005","unstructured":"Li, W. et al. Bats are natural reservoirs of SARS-like coronaviruses. Science\n\t\t\t\t\t310, 676\u2013679 (2005).","journal-title":"Science"},{"key":"10_CR5","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nature12711","volume":"503","author":"XY Ge","year":"2013","unstructured":"Ge, X. Y. et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature\n\t\t\t\t\t503, 535\u2013538 (2013).","journal-title":"Nature"},{"key":"10_CR6","doi-asserted-by":"publisher","first-page":"7070","DOI":"10.1128\/JVI.00631-14","volume":"88","author":"B He","year":"2014","unstructured":"He, B. et al. Identification of diverse alphacoronaviruses and genomic characterization of a novel severe acute respiratory syndrome-like coronavirus from bats in China. J. Virol.\n\t\t\t\t\t88, 7070\u20137082 (2014).","journal-title":"J. Virol."},{"key":"10_CR7","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1128\/JVI.02582-15","volume":"90","author":"XL Yang","year":"2016","unstructured":"Yang, X. L. et al. Isolation and characterization of a novel bat coronavirus closely related to the direct progenitor of severe acute respiratory syndrome coronavirus. J. Virol.\n\t\t\t\t\t90, 3253\u20133256 (2016).","journal-title":"J. Virol."},{"key":"10_CR8","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1093\/infdis\/jiv476","volume":"213","author":"Z Wu","year":"2016","unstructured":"Wu, Z. et al. ORF8-related genetic evidence for Chinese horseshoe bats as the source of human severe acute respiratory syndrome coronavirus. J. Infect. Dis.\n\t\t\t\t\t213, 579\u2013583 (2016).","journal-title":"J. Infect. Dis."},{"key":"10_CR9","volume":"6","author":"L Wang","year":"2017","unstructured":"Wang, L. et al. Discovery and genetic analysis of novel coronaviruses in least horseshoe bats in southwestern China. Emerg. Microbes Infect.\n\t\t\t\t\t6, e14 (2017).","journal-title":"Emerg. Microbes Infect."},{"key":"10_CR10","doi-asserted-by":"publisher","first-page":"e1006698","DOI":"10.1371\/journal.ppat.1006698","volume":"13","author":"B Hu","year":"2017","unstructured":"Hu, B. et al. Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus. PLoS Pathog.\n\t\t\t\t\t13, e1006698 (2017).","journal-title":"PLoS Pathog."},{"key":"10_CR11","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1056\/NEJMoa030747","volume":"348","author":"C Drosten","year":"2003","unstructured":"Drosten, C. et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N. Engl. J. Med.\n\t\t\t\t\t348, 1967\u20131976 (2003).","journal-title":"N. Engl. J. Med."},{"key":"10_CR12","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1056\/NEJMoa030781","volume":"348","author":"TG Ksiazek","year":"2003","unstructured":"Ksiazek, T. G. et al. A novel coronavirus associated with severe acute respiratory syndrome. N. Engl. J. Med.\n\t\t\t\t\t348, 1953\u20131966 (2003).","journal-title":"N. Engl. J. Med."},{"key":"10_CR13","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1126\/science.1085953","volume":"300","author":"MA Marra","year":"2003","unstructured":"Marra, M. A. et al. The genome sequence of the SARS-associated coronavirus. Science\n\t\t\t\t\t300, 1399\u20131404 (2003).","journal-title":"Science"},{"key":"10_CR14","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1016\/S0140-6736(03)13077-2","volume":"361","author":"JS Peiris","year":"2003","unstructured":"Peiris, J. S. et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet\n\t\t\t\t\t361, 1319\u20131325 (2003).","journal-title":"Lancet"},{"key":"10_CR15","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1126\/science.1085952","volume":"300","author":"PA Rota","year":"2003","unstructured":"Rota, P. A. et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science\n\t\t\t\t\t300, 1394\u20131399 (2003).","journal-title":"Science"},{"key":"10_CR16","volume-title":"Bats and Viruses: A New Frontier of Emerging Infectious Diseases","year":"2015","unstructured":"Wang, L.-F. & Cowled, C. (eds)\u00a0Bats and Viruses: A New Frontier of Emerging Infectious Diseases\u00a01st edn (John Wiley & Sons, Hoboken, 2015).","edition":"1st edn"},{"key":"10_CR17","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.3201\/eid2112.150283","volume":"21","author":"N Dong","year":"2015","unstructured":"Dong, N. et al. Porcine deltacoronavirus in mainland China. Emerg. Infect. Dis.\n\t\t\t\t\t21, 2254\u20132255 (2015).","journal-title":"Emerg. Infect. Dis."},{"key":"10_CR18","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1292\/jvms.15-0446","volume":"78","author":"D Sun","year":"2016","unstructured":"Sun, D., Wang, X., Wei, S., Chen, J. & Feng, L. Epidemiology and vaccine of porcine epidemic diarrhea virus in China: a mini-review. J. Vet. Med. Sci.\n\t\t\t\t\t78, 355\u2013363 (2016).","journal-title":"J. Vet. Med. Sci."},{"key":"10_CR19","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.virol.2007.06.009","volume":"367","author":"SK Lau","year":"2007","unstructured":"Lau, S. K. et al. Complete genome sequence of bat coronavirus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genome. Virology\n\t\t\t\t\t367, 428\u2013439 (2007).","journal-title":"Virology"},{"key":"10_CR20","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1007\/s00705-010-0720-2","volume":"155","author":"J Chen","year":"2010","unstructured":"Chen, J. et al. Molecular epidemiology of porcine epidemic diarrhea virus in China. Arch. Virol.\n\t\t\t\t\t155, 1471\u20131476 (2010).","journal-title":"Arch. Virol."},{"key":"10_CR21","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1128\/CVI.00350-08","volume":"16","author":"PD Burbelo","year":"2009","unstructured":"Burbelo, P. D. et al. Serological diagnosis of human herpes simplex virus type 1 and 2 infections by luciferase immunoprecipitation system assay. Clin. Vaccine Immunol.\n\t\t\t\t\t16, 366\u2013371 (2009).","journal-title":"Clin. Vaccine Immunol."},{"key":"10_CR22","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.3201\/eid2309.170915","volume":"23","author":"L Gong","year":"2017","unstructured":"Gong, L. et al. A new bat-HKU2-like coronavirus in swine, China, 2017. Emerg. Infect. Dis.\n\t\t\t\t\t23, 1607\u20131609 (2017).","journal-title":"Emerg. Infect. Dis."},{"key":"10_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.vetmic.2017.09.020","volume":"211","author":"Y Pan","year":"2017","unstructured":"Pan, Y. et al. Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China. Vet. Microbiol.\n\t\t\t\t\t211, 15\u201321 (2017).","journal-title":"Vet. Microbiol."},{"key":"10_CR24","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1038\/nature02145","volume":"426","author":"W Li","year":"2003","unstructured":"Li, W. et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature\n\t\t\t\t\t426, 450\u2013454 (2003).","journal-title":"Nature"},{"key":"10_CR25","unstructured":"Masters, P. S. & Perlman, S. in Fields Virology Vol. 2 (eds Knipe, D. M. & Howley, P. M.) 825\u2013858 (Lippincott Williams & Wilkins, Philadelphia, 2013)."},{"key":"10_CR26","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nature12005","volume":"495","author":"VS Raj","year":"2013","unstructured":"Raj, V. S. et al. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature\n\t\t\t\t\t495, 251\u2013254 (2013).","journal-title":"Nature"},{"key":"10_CR27","volume-title":"Antibodies: A Laboratory Manual","author":"E Harlow","year":"1988","unstructured":"Harlow, E. & Lane, D. Antibodies: A Laboratory Manual\u00a0(Cold Spring Harbor Laboratory Press, New York, 1988)."},{"key":"10_CR28","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1128\/JVI.01085-07","volume":"82","author":"W Ren","year":"2008","unstructured":"Ren, W. et al. Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin. J. Virol.\n\t\t\t\t\t82, 1899\u20131907 (2008).","journal-title":"J. Virol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-018-0010-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-018-0010-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-018-0010-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T17:48:52Z","timestamp":1733939332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-018-0010-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,4]]},"references-count":28,"journal-issue":{"issue":"7700","published-print":{"date-parts":[[2018,4,12]]}},"alternative-id":["10"],"URL":"https:\/\/doi.org\/10.1038\/s41586-018-0010-9","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,4]]},"assertion":[{"value":"7 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2018","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Extended Data Figures and Tables section originally published with this article was missing Tables 1\u20135. This has now been corrected.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}