{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T13:33:58Z","timestamp":1794576838488,"version":"4.9.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"7713","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1038\/s41586-018-0278-9","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T11:39:59Z","timestamp":1530617999000},"page":"259-263","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":372,"title":["Species-specific activity of antibacterial drug combinations"],"prefix":"10.1038","volume":"559","author":[{"given":"Ana Rita","family":"Brochado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Telzerow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Bobonis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Banzhaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Mateus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Selkrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Huth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bassler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Zamarre\u00f1o Beas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matylda","family":"Zietek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunniva","family":"Foerster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ezraty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Py","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Barras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail M.","family":"Savitski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peer","family":"Bork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"G\u00f6ttig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Typas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"278_CR1","unstructured":"President of the General Assembly of the United Nations. Press release: high-level meeting on antimicrobial resistance ( http:\/\/www.un.org\/pga\/71\/2016\/09\/21\/press-release-hl-meeting-on-antimicrobial-resistance\/ ) (2016)."},{"key":"278_CR2","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nature17042","volume":"529","author":"ED Brown","year":"2016","unstructured":"Brown, E. D. & Wright, G. D. Antibacterial drug discovery in the resistance era. Nature 529, 336\u2013343 (2016).","journal-title":"Nature"},{"key":"278_CR3","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","volume":"18","author":"E Tacconelli","year":"2018","unstructured":"Tacconelli, E. et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect. Dis. 18, 318\u2013327 (2018).","journal-title":"Lancet Infect. Dis."},{"key":"278_CR4","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/nchembio.559","volume":"7","author":"L Ejim","year":"2011","unstructured":"Ejim, L. et al. Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nat. Chem. Biol. 7, 348\u2013350 (2011).","journal-title":"Nat. Chem. Biol."},{"key":"278_CR5","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/nrd4675","volume":"14","author":"D Brown","year":"2015","unstructured":"Brown, D. Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void? Nat. Rev. Drug Discov. 14, 821\u2013832 (2015).","journal-title":"Nat. Rev. Drug Discov."},{"key":"278_CR6","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.cell.2007.06.049","volume":"130","author":"MA Kohanski","year":"2007","unstructured":"Kohanski, M. A., Dwyer, D. J., Hayete, B., Lawrence, C. A. & Collins, J. J. A common mechanism of cellular death induced by bactericidal antibiotics. Cell 130, 797\u2013810 (2007).","journal-title":"Cell"},{"key":"278_CR7","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1126\/science.1238328","volume":"340","author":"B Ezraty","year":"2013","unstructured":"Ezraty, B. et al. Fe\u2013S cluster biosynthesis controls uptake of aminoglycosides in a ROS-less death pathway. Science 340, 1583\u20131587 (2013).","journal-title":"Science"},{"key":"278_CR8","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/ng1755","volume":"38","author":"P Yeh","year":"2006","unstructured":"Yeh, P., Tschumi, A. I. & Kishony, R. Functional classification of drugs by properties of their pairwise interactions. Nat. Genet. 38, 489\u2013494 (2006).","journal-title":"Nat. Genet."},{"key":"278_CR9","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.celrep.2015.10.018","volume":"13","author":"N Robbins","year":"2015","unstructured":"Robbins, N. et al. An antifungal combination matrix identifies a rich pool of adjuvant molecules that enhance drug activity against diverse fungal pathogens. Cell Reports 13, 1481\u20131492 (2015).","journal-title":"Cell Reports"},{"key":"278_CR10","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.chembiol.2014.02.012","volume":"21","author":"M Cokol","year":"2014","unstructured":"Cokol, M. et al. Large-scale identification and analysis of suppressive drug interactions. Chem. Biol. 21, 541\u2013551 (2014).","journal-title":"Chem. Biol."},{"key":"278_CR11","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.cell.2009.10.025","volume":"139","author":"T Bollenbach","year":"2009","unstructured":"Bollenbach, T., Quan, S., Chait, R. & Kishony, R. Nonoptimal microbial response to antibiotics underlies suppressive drug interactions. Cell 139, 707\u2013718 (2009).","journal-title":"Cell"},{"key":"278_CR12","doi-asserted-by":"publisher","first-page":"aaf1420","DOI":"10.1126\/science.aaf1420","volume":"353","author":"M Costanzo","year":"2016","unstructured":"Costanzo, M. et al. A global genetic interaction network maps a wiring diagram of cellular function. Science 353, aaf1420 (2016).","journal-title":"Science"},{"key":"278_CR13","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.chembiol.2010.06.008","volume":"17","author":"MA Farha","year":"2010","unstructured":"Farha, M. A. & Brown, E. D. Chemical probes of Escherichia coli uncovered through chemical\u2013chemical interaction profiling with compounds of known biological activity. Chem. Biol. 17, 852\u2013862 (2010).","journal-title":"Chem. Biol."},{"key":"278_CR14","doi-asserted-by":"publisher","first-page":"17028","DOI":"10.1038\/nmicrobiol.2017.28","volume":"2","author":"JM Stokes","year":"2017","unstructured":"Stokes, J. M. et al. Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance. Nat. Microbiol. 2, 17028 (2017).","journal-title":"Nat. Microbiol."},{"key":"278_CR15","doi-asserted-by":"publisher","first-page":"807","DOI":"10.15252\/msb.20156098","volume":"11","author":"G Chevereau","year":"2015","unstructured":"Chevereau, G. & Bollenbach, T. Systematic discovery of drug interaction mechanisms. Mol. Syst. Biol. 11, 807 (2015).","journal-title":"Mol. Syst. Biol."},{"key":"278_CR16","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.molcel.2012.05.028","volume":"46","author":"CJ Ryan","year":"2012","unstructured":"Ryan, C. J. et al. Hierarchical modularity and the evolution of genetic interactomes across species. Mol. Cell 46, 691\u2013704 (2012).","journal-title":"Mol. Cell"},{"key":"278_CR17","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1128\/AAC.37.2.354","volume":"37","author":"M Vaara","year":"1993","unstructured":"Vaara, M. Outer membrane permeability barrier to azithromycin, clarithromycin, and roxithromycin in Gram-negative enteric bacteria. Antimicrob. Agents Chemother. 37, 354\u2013356 (1993).","journal-title":"Antimicrob. Agents Chemother."},{"key":"278_CR18","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1128\/AAC.25.4.534","volume":"25","author":"H Giamarellou","year":"1984","unstructured":"Giamarellou, H., Zissis, N. P., Tagari, G. & Bouzos, J. In vitro synergistic activities of aminoglycosides and new beta-lactams against multiresistant Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 25, 534\u2013536 (1984).","journal-title":"Antimicrob. Agents Chemother."},{"key":"278_CR19","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1128\/AAC.49.4.1377-1380.2005","volume":"49","author":"Y Imamura","year":"2005","unstructured":"Imamura, Y. et al. Azithromycin exhibits bactericidal effects on Pseudomonas aeruginosa through interaction with the outer membrane. Antimicrob. Agents Chemother. 49, 1377\u20131380 (2005).","journal-title":"Antimicrob. Agents Chemother."},{"key":"278_CR20","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/j.jmb.2008.11.042","volume":"385","author":"AD Petropoulos","year":"2009","unstructured":"Petropoulos, A. D. et al. Time-resolved binding of azithromycin to Escherichia coli ribosomes. J. Mol. Biol. 385, 1179\u20131192 (2009).","journal-title":"J. Mol. Biol."},{"key":"278_CR21","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/nchembio.1380","volume":"10","author":"Z Hao","year":"2014","unstructured":"Hao, Z. et al. The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli. Nat. Chem. Biol. 10, 21\u201328 (2014).","journal-title":"Nat. Chem. Biol."},{"key":"278_CR22","doi-asserted-by":"publisher","first-page":"4867","DOI":"10.1128\/JB.00680-12","volume":"194","author":"LM Chubiz","year":"2012","unstructured":"Chubiz, L. M., Glekas, G. D. & Rao, C. V. Transcriptional cross talk within the mar-sox-rob regulon in Escherichia coli is limited to the rob and marRAB operons. J. Bacteriol. 194, 4867\u20134875 (2012).","journal-title":"J. Bacteriol."},{"key":"278_CR23","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1093\/jac\/dkt088","volume":"68","author":"S G\u00f6ttig","year":"2013","unstructured":"G\u00f6ttig, S., Hamprecht, A. G., Christ, S., Kempf, V. A. & Wichelhaus, T. A. Detection of NDM-7 in Germany, a new variant of the New Delhi metallo-\u03b2-lactamase with increased carbapenemase activity. J. Antimicrob. Chemother. 68, 1737\u20131740 (2013).","journal-title":"J. Antimicrob. Chemother."},{"key":"278_CR24","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1093\/cid\/civ191","volume":"60","author":"S G\u00f6ttig","year":"2015","unstructured":"G\u00f6ttig, S., Gruber, T. M., Stecher, B., Wichelhaus, T. A. & Kempf, V. A. In vivo horizontal gene transfer of the carbapenemase OXA-48 during a nosocomial outbreak. Clin. Infect. Dis. 60, 1808\u20131815 (2015).","journal-title":"Clin. Infect. Dis."},{"key":"278_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02875-z","volume":"9","author":"CR MacNair","year":"2018","unstructured":"MacNair, C. R. et al. Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics. Nat. Commun. 9, 458 (2018).","journal-title":"Nat. Commun."},{"key":"278_CR26","doi-asserted-by":"publisher","first-page":"2006.0008","DOI":"10.1038\/msb4100050","volume":"2","author":"T Baba","year":"2006","unstructured":"Baba, T. et al. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2, 2006.0008 (2006).","journal-title":"Mol. Syst. Biol."},{"key":"278_CR27","doi-asserted-by":"publisher","unstructured":"Yardeni, E. H., Zomot, E. & Bibi, E. The fascinating but mysterious mechanistic aspects of multidrug transport by MdfA from Escherichia coli. Res. Microbiol. https:\/\/doi.org\/10.1016\/j.resmic.2017.09.004 (2017).","DOI":"10.1016\/j.resmic.2017.09.004"},{"key":"278_CR28","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.1128\/JB.180.22.6072-6075.1998","volume":"180","author":"C Bohn","year":"1998","unstructured":"Bohn, C. & Bouloc, P. The Escherichia coli cmlA gene encodes the multidrug efflux pump Cmr\/MdfA and is responsible for isopropyl-\u03b2-d-thiogalactopyranoside exclusion and spectinomycin sensitivity. J. Bacteriol. 180, 6072\u20136075 (1998).","journal-title":"J. Bacteriol."},{"key":"278_CR29","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.cell.2010.11.052","volume":"144","author":"RJ Nichols","year":"2011","unstructured":"Nichols, R. J. et al. Phenotypic landscape of a bacterial cell. Cell 144, 143\u2013156 (2011).","journal-title":"Cell"},{"key":"278_CR30","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.cels.2015.12.003","volume":"1","author":"J Wildenhain","year":"2015","unstructured":"Wildenhain, J. et al. Prediction of synergism from chemical\u2013genetic interactions by machine learning. Cell Syst. 1, 383\u2013395 (2015).","journal-title":"Cell Syst."},{"key":"278_CR31","doi-asserted-by":"publisher","first-page":"872","DOI":"10.15252\/msb.20156777","volume":"12","author":"S Chandrasekaran","year":"2016","unstructured":"Chandrasekaran, S. et al. Chemogenomics and orthology-based design of antibiotic combination therapies. Mol. Syst. Biol. 12, 872 (2016).","journal-title":"Mol. Syst. Biol."},{"key":"278_CR32","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1038\/nbt.1549","volume":"27","author":"J Leh\u00e1r","year":"2009","unstructured":"Leh\u00e1r, J. et al. Synergistic drug combinations tend to improve therapeutically relevant selectivity. Nat. Biotechnol. 27, 659\u2013666 (2009).","journal-title":"Nat. Biotechnol."},{"key":"278_CR33","doi-asserted-by":"publisher","first-page":"6640","DOI":"10.1073\/pnas.120163297","volume":"97","author":"KA Datsenko","year":"2000","unstructured":"Datsenko, K. A. & Wanner, B. L. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl Acad. Sci. USA 97, 6640\u20136645 (2000).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"278_CR34","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1093\/dnares\/12.1.63","volume":"12","author":"K Saka","year":"2005","unstructured":"Saka, K. et al. A complete set of Escherichia coli open reading frames in mobile plasmids facilitating genetic studies. DNA Res. 12, 63\u201368 (2005).","journal-title":"DNA Res."},{"key":"278_CR35","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498\u20132504 (2003).","journal-title":"Genome Res."},{"key":"278_CR36","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/nrmicro2133","volume":"7","author":"PJ Yeh","year":"2009","unstructured":"Yeh, P. J., Hegreness, M. J., Aiden, A. P. & Kishony, R. Drug interactions and the evolution of antibiotic resistance. Nat. Rev. Microbiol. 7, 460\u2013466 (2009).","journal-title":"Nat. Rev. Microbiol."},{"key":"278_CR37","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1111\/j.1744-7348.1939.tb06990.x","volume":"26","author":"CI Bliss","year":"1939","unstructured":"Bliss, C. I. The toxicity of poisons applied jointly. Ann. Appl. Biol. 26, 585\u2013615 (1939).","journal-title":"Ann. Appl. Biol."},{"key":"278_CR38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/BF02322290","volume":"27","author":"S Loewe","year":"1928","unstructured":"Loewe, S. Die quantitativen Probleme der Pharmakologie. Ergeb. Physiol. 27, 47\u2013187 (1928).","journal-title":"Ergeb. Physiol."},{"key":"278_CR39","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/ng.846","volume":"43","author":"B Szappanos","year":"2011","unstructured":"Szappanos, B. et al. An integrated approach to characterize genetic interaction networks in yeast metabolism. Nat. Genet. 43, 656\u2013662 (2011).","journal-title":"Nat. Genet."},{"key":"278_CR40","doi-asserted-by":"publisher","first-page":"E6231","DOI":"10.1073\/pnas.1701848114","volume":"114","author":"A Mateus","year":"2017","unstructured":"Mateus, A. et al. Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery. Proc. Natl Acad. Sci. USA 114, E6231\u2013E6239 (2017).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"278_CR41","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nature22308","volume":"545","author":"MF Richter","year":"2017","unstructured":"Richter, M. F. et al. Predictive compound accumulation rules yield a broad-spectrum antibiotic. Nature 545, 299\u2013304 (2017).","journal-title":"Nature"},{"key":"278_CR42","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1093\/jac\/43.1.61","volume":"43","author":"LJ Piddock","year":"1999","unstructured":"Piddock, L. J., Jin, Y. F., Ricci, V. & Asuquo, A. E. Quinolone accumulation by Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli. J. Antimicrob. Chemother. 43, 61\u201370 (1999).","journal-title":"J. Antimicrob. Chemother."},{"key":"278_CR43","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394C t\u00a0method. Methods 25, 402\u2013408 (2001).","journal-title":"Methods"},{"key":"278_CR44","doi-asserted-by":"publisher","first-page":"17014","DOI":"10.1038\/nmicrobiol.2017.14","volume":"2","author":"G Kritikos","year":"2017","unstructured":"Kritikos, G. et al. A tool named Iris for versatile high-throughput phenotyping in microorganisms. Nat. Microbiol. 2, 17014 (2017).","journal-title":"Nat. Microbiol."},{"key":"278_CR45","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S1473-3099(04)01108-9","volume":"4","author":"N Safdar","year":"2004","unstructured":"Safdar, N., Handelsman, J. & Maki, D. G. Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? A meta-analysis. Lancet Infect. Dis. 4, 519\u2013527 (2004).","journal-title":"Lancet Infect. Dis."},{"key":"278_CR46","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1128\/MMBR.51.4.439-457.1987","volume":"51","author":"HW Taber","year":"1987","unstructured":"Taber, H. W., Mueller, J. P., Miller, P. F. & Arrow, A. S. Bacterial uptake of aminoglycoside antibiotics. Microbiol. Rev. 51, 439\u2013457 (1987).","journal-title":"Microbiol. Rev."},{"key":"278_CR47","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1128\/AAC.44.12.3441-3443.2000","volume":"44","author":"A Mazzariol","year":"2000","unstructured":"Mazzariol, A., Tokue, Y., Kanegawa, T. M., Cornaglia, G. & Nikaido, H. High-level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA. Antimicrob. Agents Chemother. 44, 3441\u20133443 (2000).","journal-title":"Antimicrob. Agents Chemother."},{"key":"278_CR48","doi-asserted-by":"publisher","first-page":"6164","DOI":"10.1073\/pnas.83.16.6164","volume":"83","author":"BD Davis","year":"1986","unstructured":"Davis, B. D., Chen, L. L. & Tai, P. C. Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides. Proc. Natl Acad. Sci. USA 83, 6164\u20136168 (1986).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"278_CR49","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1128\/AAC.38.8.1773","volume":"38","author":"PF Miller","year":"1994","unstructured":"Miller, P. F., Gambino, L. F., Sulavik, M. C. & Gracheck, S. J. Genetic relationship between soxRS and mar loci in promoting multiple antibiotic resistance in Escherichia coli. Antimicrob. Agents Chemother. 38, 1773\u20131779 (1994).","journal-title":"Antimicrob. Agents Chemother."},{"key":"278_CR50","doi-asserted-by":"publisher","first-page":"2822","DOI":"10.1016\/j.bbamem.2007.07.016","volume":"1768","author":"F Fernandes","year":"2007","unstructured":"Fernandes, F., Neves, P., Gameiro, P., Loura, L. M. & Prieto, M. Ciprofloxacin interactions with bacterial protein OmpF: modelling of FRET from a multi-tryptophan protein trimer. Biochim. Biophys. Acta 1768, 2822\u20132830 (2007).","journal-title":"Biochim. Biophys. Acta"},{"key":"278_CR51","doi-asserted-by":"publisher","first-page":"e0149326","DOI":"10.1371\/journal.pone.0149326","volume":"11","author":"D Machado","year":"2016","unstructured":"Machado, D. et al. Ion channel blockers as antimicrobial agents, efflux inhibitors, and enhancers of macrophage killing activity against drug resistant Mycobacterium tuberculosis. PLoS ONE 11, e0149326 (2016).","journal-title":"PLoS ONE"},{"key":"278_CR52","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nature25979","volume":"555","author":"L Maier","year":"2018","unstructured":"Maier, L. et al. Extensive impact of non-antibiotic drugs on human gut bacteria. Nature 555, 623\u2013628 (2018).","journal-title":"Nature"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41586-018-0278-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-018-0278-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-018-0278-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T17:47:21Z","timestamp":1684604841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-018-0278-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":52,"journal-issue":{"issue":"7713","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["278"],"URL":"https:\/\/doi.org\/10.1038\/s41586-018-0278-9","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733574700.793548380","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.733574700.793548013","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"11 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"EMBL has filed a patent application on using drug combinations identified in this study for prevention and\/or treatment of infections and antibacterial-induced dysfunctions (European patent application number EP18169989.3). A.B., S.G. and A.Ty. are listed as inventors.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}