{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T04:29:32Z","timestamp":1794198572197,"version":"4.8.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7739","license":[{"start":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1038\/s41586-018-0812-9","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T13:48:16Z","timestamp":1545313696000},"page":"366-371","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":381,"title":["Tissue-resident memory CD8+ T cells promote melanoma\u2013immune equilibrium in skin"],"prefix":"10.1038","volume":"565","author":[{"given":"Simone L.","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Buzzai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai","family":"Rautela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh Liang","family":"Hor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Hochheiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Effern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"McBain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teagan","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarem","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"McConville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Wilmott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Scolyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"T\u00fcting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umaimainthan","family":"Palendira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gyorki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott N.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas D.","family":"Huntington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammy","family":"Bedoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"H\u00f6lzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura K.","family":"Mackay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Waithman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gebhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,31]]},"reference":[{"key":"812_CR1","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1126\/science.1203486","volume":"331","author":"RD Schreiber","year":"2011","unstructured":"Schreiber, R. D., Old, L. J. & Smyth, M. J. Cancer immunoediting: integrating immunity\u2019s roles in cancer suppression and promotion. Science 331, 1565\u20131570 (2011).","journal-title":"Science"},{"key":"812_CR2","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1056\/NEJM200302063480620","volume":"348","author":"RM MacKie","year":"2003","unstructured":"MacKie, R. M., Reid, R. & Junor, B. Fatal melanoma transferred in a donated kidney 16 years after melanoma surgery. N. Engl. J. Med. 348, 567\u2013568 (2003).","journal-title":"N. Engl. J. Med."},{"key":"812_CR3","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1038\/nature06309","volume":"450","author":"CM Koebel","year":"2007","unstructured":"Koebel, C. M. et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 450, 903\u2013907 (2007).","journal-title":"Nature"},{"key":"812_CR4","doi-asserted-by":"publisher","first-page":"3987","DOI":"10.1158\/0008-5472.CAN-12-1337","volume":"72","author":"MW Teng","year":"2012","unstructured":"Teng, M. W. et al. Opposing roles for IL-23 and IL-12 in maintaining occult cancer in an equilibrium state. Cancer Res. 72, 3987\u20133996 (2012).","journal-title":"Cancer Res."},{"key":"812_CR5","doi-asserted-by":"publisher","first-page":"e1019198","DOI":"10.1080\/2162402X.2015.1019198","volume":"4","author":"B Wylie","year":"2015","unstructured":"Wylie, B. et al. Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103\u2212 and XCR1+CD103+ dendritic cells. OncoImmunology 4, e1019198 (2015).","journal-title":"OncoImmunology"},{"key":"812_CR6","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature10339","volume":"477","author":"T Gebhardt","year":"2011","unstructured":"Gebhardt, T. et al. Different patterns of peripheral migration by memory CD4+ and CD8+ T cells. Nature 477, 216\u2013219 (2011).","journal-title":"Nature"},{"key":"812_CR7","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nature10851","volume":"483","author":"X Jiang","year":"2012","unstructured":"Jiang, X. et al. Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity. Nature 483, 227\u2013231 (2012).","journal-title":"Nature"},{"key":"812_CR8","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/ni.1718","volume":"10","author":"T Gebhardt","year":"2009","unstructured":"Gebhardt, T. et al. Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nature Immunol. 10, 524\u2013530 (2009).","journal-title":"Nature Immunol."},{"key":"812_CR9","doi-asserted-by":"publisher","first-page":"19739","DOI":"10.1073\/pnas.1208927109","volume":"109","author":"S Ariotti","year":"2012","unstructured":"Ariotti, S. et al. Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proc. Natl Acad. Sci. USA 109, 19739\u201319744 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"812_CR10","doi-asserted-by":"publisher","first-page":"7037","DOI":"10.1073\/pnas.1202288109","volume":"109","author":"LK Mackay","year":"2012","unstructured":"Mackay, L. K. et al. Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation. Proc. Natl Acad. Sci. USA 109, 7037\u20137042 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"812_CR11","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/imr.12650","volume":"283","author":"T Gebhardt","year":"2018","unstructured":"Gebhardt, T., Palendira, U., Tscharke, D. C. & Bedoui, S. Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance. Immunol. Rev. 283, 54\u201376 (2018).","journal-title":"Immunol. Rev."},{"key":"812_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16073","volume":"8","author":"M Enamorado","year":"2017","unstructured":"Enamorado, M. et al. Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells. Nat. Commun. 8, 16073 (2017).","journal-title":"Nat. Commun."},{"key":"812_CR13","doi-asserted-by":"publisher","first-page":"eaam6346","DOI":"10.1126\/sciimmunol.aam6346","volume":"2","author":"BT Malik","year":"2017","unstructured":"Malik, B. T. et al. Resident memory T cells in the skin mediate durable immunity to melanoma. Sci. Immunol. 2, eaam6346 (2017).","journal-title":"Sci. Immunol."},{"key":"812_CR14","doi-asserted-by":"publisher","first-page":"573","DOI":"10.3389\/fimmu.2016.00573","volume":"7","author":"T Murray","year":"2016","unstructured":"Murray, T. et al. Very late antigen-1 marks functional tumor-resident CD8 T cells and correlates with survival of melanoma patients. Front. Immunol. 7, 573 (2016).","journal-title":"Front. Immunol."},{"key":"812_CR15","doi-asserted-by":"publisher","first-page":"e88955","DOI":"10.1172\/jci.insight.88955","volume":"1","author":"CS Boddupalli","year":"2016","unstructured":"Boddupalli, C. S. et al. Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cells. JCI Insight 1, e88955 (2016).","journal-title":"JCI Insight"},{"key":"812_CR16","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1002\/ijc.28391","volume":"134","author":"EP Salerno","year":"2014","unstructured":"Salerno, E. P., Olson, W. C., McSkimming, C., Shea, S. & Slingluff, C. L. Jr T cells in the human metastatic melanoma microenvironment express site-specific homing receptors and retention integrins. Int. J. Cancer 134, 563\u2013574 (2014).","journal-title":"Int. J. Cancer"},{"key":"812_CR17","doi-asserted-by":"publisher","first-page":"3036","DOI":"10.1158\/1078-0432.CCR-17-2257","volume":"24","author":"J Edwards","year":"2018","unstructured":"Edwards, J. et al. CD103+ tumor-resident CD8+ T cells are associated with improved survival in immunotherapy naive melanoma patients and expand significantly during anti-PD1 treatment. Clin. Cancer Res. 24, 3036\u20133045 (2018).","journal-title":"Clin. Cancer Res."},{"key":"812_CR18","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1038\/ni.2744","volume":"14","author":"LK Mackay","year":"2013","unstructured":"Mackay, L. K. et al. The developmental pathway for CD103+ CD8+ tissue-resident memory T cells of skin. Nat. Immunol. 14, 1294\u20131301 (2013).","journal-title":"Nat. Immunol."},{"key":"812_CR19","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/ni.2568","volume":"14","author":"JM Schenkel","year":"2013","unstructured":"Schenkel, J. M., Fraser, K. A., Vezys, V. & Masopust, D. Sensing and alarm function of resident memory CD8+ T cells. Nat. Immunol. 14, 509\u2013513 (2013).","journal-title":"Nat. Immunol."},{"key":"812_CR20","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nature11538","volume":"490","author":"J Landsberg","year":"2012","unstructured":"Landsberg, J. et al. Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation. Nature 490, 412\u2013416 (2012).","journal-title":"Nature"},{"key":"812_CR21","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nature11824","volume":"494","author":"H Braum\u00fcller","year":"2013","unstructured":"Braum\u00fcller, H. et al. T-helper-1-cell cytokines drive cancer into senescence. Nature 494, 361\u2013365 (2013).","journal-title":"Nature"},{"key":"812_CR22","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1158\/1078-0432.CCR-13-1877","volume":"20","author":"JR Webb","year":"2014","unstructured":"Webb, J. R., Milne, K., Watson, P., Deleeuw, R. J. & Nelson, B. H. Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer. Clin. Cancer Res. 20, 434\u2013444 (2014).","journal-title":"Clin. Cancer Res."},{"key":"812_CR23","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.4049\/jimmunol.1402711","volume":"194","author":"F Djenidi","year":"2015","unstructured":"Djenidi, F. et al. CD8+ CD103+ tumor-infiltrating lymphocytes are tumor-specific tissue-resident memory T cells and a prognostic factor for survival in lung cancer patients. J. Immunol. 194, 3475\u20133486 (2015).","journal-title":"J. Immunol."},{"key":"812_CR24","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.juro.2015.02.2941","volume":"194","author":"B Wang","year":"2015","unstructured":"Wang, B. et al. CD103+ tumor infiltrating lymphocytes predict a favorable prognosis in urothelial cell carcinoma of the bladder. J. Urol. 194, 556\u2013562 (2015).","journal-title":"J. Urol."},{"key":"812_CR25","doi-asserted-by":"publisher","first-page":"e1338230","DOI":"10.1080\/2162402X.2017.1338230","volume":"6","author":"FL Komdeur","year":"2017","unstructured":"Komdeur, F. L. et al. CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer. OncoImmunology 6, e1338230 (2017).","journal-title":"OncoImmunology"},{"key":"812_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15221","volume":"8","author":"M Nizard","year":"2017","unstructured":"Nizard, M. et al. Induction of resident memory T cells enhances the efficacy of cancer vaccine. Nat. Commun. 8, 15221 (2017).","journal-title":"Nat. Commun."},{"key":"812_CR27","doi-asserted-by":"publisher","first-page":"9090","DOI":"10.1073\/pnas.1303858110","volume":"110","author":"IA Cockburn","year":"2013","unstructured":"Cockburn, I. A. et al. In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages. Proc. Natl Acad. Sci. USA 110, 9090\u20139095 (2013).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"812_CR28","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.immuni.2016.01.010","volume":"44","author":"S Halle","year":"2016","unstructured":"Halle, S. et al. In vivo killing capacity of cytotoxic T cells is limited and involves dynamic interactions and T cell cooperativity. Immunity 44, 233\u2013245 (2016).","journal-title":"Immunity"},{"key":"812_CR29","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/nature12110","volume":"497","author":"J Zhu","year":"2013","unstructured":"Zhu, J. et al. Immune surveillance by CD8\u03b1\u03b1+ skin-resident T cells in human herpes virus infection. Nature 497, 494\u2013497 (2013); corrigendum 500, 242 (2013).","journal-title":"Nature"},{"key":"812_CR30","doi-asserted-by":"publisher","first-page":"e1005799","DOI":"10.1371\/journal.ppat.1005799","volume":"12","author":"HG Woon","year":"2016","unstructured":"Woon, H. G. et al. Compartmentalization of total and virus-specific tissue-resident memory CD8+ T cells in human lymphoid organs. PLoS Pathog. 12, e1005799 (2016).","journal-title":"PLoS Pathog."},{"key":"812_CR31","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1046\/j.1440-1711.2002.01071.x","volume":"80","author":"SN Mueller","year":"2002","unstructured":"Mueller, S. N., Heath, W., McLain, J. D., Carbone, F. R. & Jones, C. M. Characterization of two TCR transgenic mouse lines specific for herpes simplex virus. Immunol. Cell Biol. 80, 156\u2013163 (2002).","journal-title":"Immunol. Cell Biol."},{"key":"812_CR32","doi-asserted-by":"publisher","first-page":"392","DOI":"10.4049\/jimmunol.172.1.392","volume":"172","author":"A Lint van","year":"2004","unstructured":"van Lint, A. et al. Herpes simplex virus-specific CD8+ T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation. J. Immunol. 172, 392\u2013397 (2004).","journal-title":"J. Immunol."}],"updated-by":[{"DOI":"10.1038\/s41586-019-0958-0","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41586-018-0812-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-018-0812-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-018-0812-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T17:51:52Z","timestamp":1684605112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-018-0812-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,31]]},"references-count":32,"journal-issue":{"issue":"7739","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["812"],"URL":"https:\/\/doi.org\/10.1038\/s41586-018-0812-9","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734707368.793575845","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.734707368.793559644","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,31]]},"assertion":[{"value":"4 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2019","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Panel j was inadvertently labelled as panel k in the caption to Fig. 4. Similarly, \u2018Fig. 4k\u2019 should have been \u2018Fig. 4j\u2019 in the sentence beginning \u2018TNF-\u03b1-deficient gBT-I cells were\u2026\u2019. In addition, the surname of author Umaimainthan Palendira was misspelled \u2018Palendria\u2019. These errors have been corrected online.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}