{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T12:32:06Z","timestamp":1794486726946,"version":"4.9.1"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"7772","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2019,9,5]]},"DOI":"10.1038\/s41586-019-1506-7","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T14:02:44Z","timestamp":1566396164000},"page":"61-68","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1868,"title":["Conserved cell types with divergent features in human versus mouse cortex"],"prefix":"10.1038","volume":"573","author":[{"given":"Rebecca D.","family":"Hodge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trygve E.","family":"Bakken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy A.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza R.","family":"Barkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas T.","family":"Graybuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie L.","family":"Close","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osnat","family":"Penn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhen","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Eggermont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"H\u00f6llt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boaz P.","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya I.","family":"Shehata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Aevermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Beller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Bertagnolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krissy","family":"Brouner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Casper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Cobbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Dalley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Dee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Lin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Ellenbogen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Garren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Goldy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryder P.","family":"Gwinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hirschstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Dirk","family":"Keene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Keshk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanan","family":"Lathia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mahfouz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe","family":"Maltzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medea","family":"McGraw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuc Nghi","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Nyhus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey G.","family":"Ojemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Oldre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheana","family":"Parry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Rimorin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadiya V.","family":"Shapovalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroja","family":"Somasundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Szafer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot R.","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Quon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Scheuermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Yuste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Sunkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boudewijn","family":"Lelieveldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hawrylycz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bosiljka","family":"Tasic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan R.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed S.","family":"Lein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"1506_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/nature18933","volume":"536","author":"MF Glasser","year":"2016","unstructured":"Glasser, M. F. et al. A multi-modal parcellation of human cerebral cortex. Nature 536, 171\u2013178 (2016).","journal-title":"Nature"},{"key":"1506_CR2","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1002\/cne.21974","volume":"513","author":"FAC Azevedo","year":"2009","unstructured":"Azevedo, F. A. C. et al. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J. Comp. Neurol. 513, 532\u2013541 (2009).","journal-title":"J. Comp. Neurol."},{"key":"1506_CR3","doi-asserted-by":"publisher","first-page":"12138","DOI":"10.1073\/pnas.0604911103","volume":"103","author":"S Herculano-Houzel","year":"2006","unstructured":"Herculano-Houzel, S., Mota, B. & Lent, R. Cellular scaling rules for rodent brains. Proc. Natl Acad. Sci. USA 103, 12138\u201312143 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1506_CR4","first-page":"29","volume":"5","author":"J DeFelipe","year":"2011","unstructured":"DeFelipe, J. The evolution of the brain, the human nature of cortical circuits, and intellectual creativity. Front. Neuroanat. 5, 29 (2011).","journal-title":"Front. Neuroanat."},{"key":"1506_CR5","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.celrep.2018.03.111","volume":"23","author":"RB Poorthuis","year":"2018","unstructured":"Poorthuis, R. B. et al. Rapid neuromodulation of layer 1 interneurons in human neocortex. Cell Rep. 23, 951\u2013958 (2018).","journal-title":"Cell Rep."},{"key":"1506_CR6","doi-asserted-by":"publisher","first-page":"e16553","DOI":"10.7554\/eLife.16553","volume":"5","author":"G Eyal","year":"2016","unstructured":"Eyal, G. et al. Unique membrane properties and enhanced signal processing in human neocortical neurons. eLife 5, e16553 (2016).","journal-title":"eLife"},{"key":"1506_CR7","doi-asserted-by":"publisher","first-page":"e2000237","DOI":"10.1371\/journal.pbio.2000237","volume":"14","author":"V Szegedi","year":"2016","unstructured":"Szegedi, V. et al. Plasticity in single axon glutamatergic connection to GABAergic interneurons regulates complex events in the human neocortex. PLoS Biol. 14, e2000237 (2016).","journal-title":"PLoS Biol."},{"key":"1506_CR8","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1023\/A:1024134312173","volume":"31","author":"R Benavides-Piccione","year":"2002","unstructured":"Benavides-Piccione, R., Ballesteros-Y\u00e1\u00f1ez, I., DeFelipe, J. & Yuste, R. Cortical area and species differences in dendritic spine morphology. J. Neurocytol. 31, 337\u2013346 (2002).","journal-title":"J. Neurocytol."},{"key":"1506_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fnana.2016.00028","volume":"10","author":"PL Gabbott","year":"2016","unstructured":"Gabbott, P. L. Subpial fan cell\u2014a class of calretinin neuron in layer 1 of adult monkey prefrontal cortex. Front. Neuroanat. 10, 28 (2016).","journal-title":"Front. Neuroanat."},{"key":"1506_CR10","unstructured":"Ram\u00f3n y Cajal, S. La Textura del Sistema Nerviosa del Hombre y los Vertebrados (Nicolas Moya, 1904)."},{"key":"1506_CR11","first-page":"41","volume":"20","author":"R Lorente de N\u00f3","year":"1922","unstructured":"Lorente de N\u00f3, R. La corteza cerebral del rat\u00f3n. Trab. Lab. Invest. Bio. (Madrid) 20, 41\u201378 (1922).","journal-title":"Trab. Lab. Invest. Bio. (Madrid)"},{"key":"1506_CR12","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nature04103","volume":"437","author":"RS Hill","year":"2005","unstructured":"Hill, R. S. & Walsh, C. A. Molecular insights into human brain evolution. Nature 437, 64\u201367 (2005).","journal-title":"Nature"},{"key":"1506_CR13","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1523\/JNEUROSCI.4707-08.2009","volume":"29","author":"NA Oberheim","year":"2009","unstructured":"Oberheim, N. A. et al. Uniquely hominid features of adult human astrocytes. J. Neurosci. 29, 3276\u20133287 (2009).","journal-title":"J. Neurosci."},{"key":"1506_CR14","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1038\/s41593-018-0205-2","volume":"21","author":"E Boldog","year":"2018","unstructured":"Boldog, E. et al. Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type. Nat. Neurosci. 21, 1185\u20131195 (2018).","journal-title":"Nat. Neurosci."},{"key":"1506_CR15","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.cell.2012.02.052","volume":"149","author":"H Zeng","year":"2012","unstructured":"Zeng, H. et al. Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures. Cell 149, 483\u2013496 (2012).","journal-title":"Cell"},{"key":"1506_CR16","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/nature18637","volume":"535","author":"TE Bakken","year":"2016","unstructured":"Bakken, T. E. et al. A comprehensive transcriptional map of primate brain development. Nature 535, 367\u2013375 (2016).","journal-title":"Nature"},{"key":"1506_CR17","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1038\/nn.4171","volume":"18","author":"M Hawrylycz","year":"2015","unstructured":"Hawrylycz, M. et al. Canonical genetic signatures of the adult human brain. Nat. Neurosci. 18, 1832\u20131844 (2015).","journal-title":"Nat. Neurosci."},{"key":"1506_CR18","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.neuron.2017.10.007","volume":"96","author":"JR Ecker","year":"2017","unstructured":"Ecker, J. R. et al. The BRAIN initiative cell census consortium: lessons learned toward generating a comprehensive Brain Cell Atlas. Neuron 96, 542\u2013557 (2017).","journal-title":"Neuron"},{"key":"1506_CR19","doi-asserted-by":"publisher","first-page":"e27041","DOI":"10.7554\/eLife.27041","volume":"6","author":"A Regev","year":"2017","unstructured":"Regev, A. et al. The Human Cell Atlas. eLife 6, e27041 (2017).","journal-title":"eLife"},{"key":"1506_CR20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nn.4216","volume":"19","author":"B Tasic","year":"2016","unstructured":"Tasic, B. et al. Adult mouse cortical cell taxonomy revealed by single cell transcriptomics. Nat. Neurosci. 19, 335\u2013346 (2016).","journal-title":"Nat. Neurosci."},{"key":"1506_CR21","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1126\/science.aaa1934","volume":"347","author":"A Zeisel","year":"2015","unstructured":"Zeisel, A. et al. Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq. Science 347, 1138\u20131142 (2015).","journal-title":"Science"},{"key":"1506_CR22","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41586-018-0654-5","volume":"563","author":"B Tasic","year":"2018","unstructured":"Tasic, B. et al. Shared and distinct transcriptomic cell types across neocortical areas. Nature 563, 72\u201378 (2018).","journal-title":"Nature"},{"key":"1506_CR23","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nprot.2016.015","volume":"11","author":"SR Krishnaswami","year":"2016","unstructured":"Krishnaswami, S. R. et al. Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons. Nat. Protoc. 11, 499\u2013524 (2016).","journal-title":"Nat. Protoc."},{"key":"1506_CR24","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1126\/science.aaf1204","volume":"352","author":"BB Lake","year":"2016","unstructured":"Lake, B. B. et al. Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain. Science 352, 1586\u20131590 (2016).","journal-title":"Science"},{"key":"1506_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04426-w","volume":"7","author":"BB Lake","year":"2017","unstructured":"Lake, B. B. et al. A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA. Sci. Rep. 7, 6031 (2017).","journal-title":"Sci. Rep."},{"key":"1506_CR26","doi-asserted-by":"publisher","first-page":"e0209648","DOI":"10.1371\/journal.pone.0209648","volume":"13","author":"TE Bakken","year":"2018","unstructured":"Bakken, T. E. et al. Single-nucleus and single-cell transcriptomes compared in matched cortical cell types. PLoS ONE 13, e0209648 (2018).","journal-title":"PLoS ONE"},{"key":"1506_CR27","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/nbt.4038","volume":"36","author":"BB Lake","year":"2018","unstructured":"Lake, B. B. et al. Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain. Nat. Biotechnol. 36, 70\u201380 (2018).","journal-title":"Nat. Biotechnol."},{"key":"1506_CR28","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/nmeth.4407","volume":"14","author":"N Habib","year":"2017","unstructured":"Habib, N. et al. Massively parallel single-nucleus RNA-seq with DroNc-seq. Nat. Methods 14, 955\u2013958 (2017).","journal-title":"Nat. Methods"},{"key":"1506_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05882-0","volume":"7","author":"Y Zhu","year":"2017","unstructured":"Zhu, Y., Wang, L., Yin, Y. & Yang, E. Systematic analysis of gene expression patterns associated with postmortem interval in human tissues. Sci. Rep. 7, 5435 (2017).","journal-title":"Sci. Rep."},{"key":"1506_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1977-1","volume":"18","author":"T Bakken","year":"2017","unstructured":"Bakken, T. et al. Cell type discovery and representation in the era of high-content single cell phenotyping. BMC Bioinformatics 18, 559 (2017).","journal-title":"BMC Bioinformatics"},{"key":"1506_CR31","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/nsmb.3424","volume":"24","author":"MS Werner","year":"2017","unstructured":"Werner, M. S. et al. Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription. Nat. Struct. Mol. Biol. 24, 596\u2013603 (2017).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"1506_CR32","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1101\/gr.132159.111","volume":"22","author":"T Derrien","year":"2012","unstructured":"Derrien, T. et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 22, 1775\u20131789 (2012).","journal-title":"Genome Res."},{"key":"1506_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-0932-1","volume":"17","author":"SJ Liu","year":"2016","unstructured":"Liu, S. J. et al. Single-cell analysis of long non-coding RNAs in the developing human neocortex. Genome Biol. 17, 67 (2016).","journal-title":"Genome Biol."},{"key":"1506_CR34","unstructured":"von Economo, C. Cellular structure of the human cerebral cortex. (Karger, 2009)."},{"key":"1506_CR35","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.neuron.2018.10.012","volume":"100","author":"BE Kalmbach","year":"2018","unstructured":"Kalmbach, B. E. et al. h-Channels contribute to divergent intrinsic membrane properties of supragranular pyramidal neurons in human versus mouse cerebral cortex. Neuron 100, 1194\u20131208 (2018).","journal-title":"Neuron"},{"key":"1506_CR36","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1038\/nn.3541","volume":"16","author":"DV Hansen","year":"2013","unstructured":"Hansen, D. V. et al. Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences. Nat. Neurosci. 16, 1576\u20131587 (2013).","journal-title":"Nat. Neurosci."},{"key":"1506_CR37","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1038\/nn.3536","volume":"16","author":"T Ma","year":"2013","unstructured":"Ma, T. et al. Subcortical origins of human and monkey neocortical interneurons. Nat. Neurosci. 16, 1588\u20131597 (2013).","journal-title":"Nat. Neurosci."},{"key":"1506_CR38","doi-asserted-by":"publisher","first-page":"16796","DOI":"10.1523\/JNEUROSCI.1869-10.2010","volume":"30","author":"S Lee","year":"2010","unstructured":"Lee, S., Hjerling-Leffler, J., Zagha, E., Fishell, G. & Rudy, B. The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors. J. Neurosci. 30, 16796\u201316808 (2010).","journal-title":"J. Neurosci."},{"key":"1506_CR39","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1002\/ajp.22082","volume":"75","author":"MA Raghanti","year":"2013","unstructured":"Raghanti, M. A. et al. Neuropeptide Y-immunoreactive neurons in the cerebral cortex of humans and other haplorrhine primates. Am. J. Primatol. 75, 415\u2013424 (2013).","journal-title":"Am. J. Primatol."},{"key":"1506_CR40","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/cne.22229","volume":"518","author":"X Xu","year":"2010","unstructured":"Xu, X., Roby, K. D. & Callaway, E. M. Immunochemical characterization of inhibitory mouse cortical neurons: three chemically distinct classes of inhibitory cells. J. Comp. Neurol. 518, 389\u2013404 (2010).","journal-title":"J. Comp. Neurol."},{"key":"1506_CR41","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.cell.2017.08.032","volume":"171","author":"A Paul","year":"2017","unstructured":"Paul, A. et al. Transcriptional architecture of synaptic communication delineates GABAergic neuron identity. Cell 171, 522\u2013539 (2017).","journal-title":"Cell"},{"key":"1506_CR42","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1523\/JNEUROSCI.4515-09.2010","volume":"30","author":"G Miyoshi","year":"2010","unstructured":"Miyoshi, G. et al. Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons. J. Neurosci. 30, 1582\u20131594 (2010).","journal-title":"J. Neurosci."},{"key":"1506_CR43","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.neuron.2015.11.013","volume":"89","author":"Y Zhang","year":"2016","unstructured":"Zhang, Y. et al. Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse. Neuron 89, 37\u201353 (2016).","journal-title":"Neuron"},{"key":"1506_CR44","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol. 36, 411\u2013420 (2018).","journal-title":"Nat. Biotechnol."},{"key":"1506_CR45","doi-asserted-by":"crossref","unstructured":"Johansen, N. & Quon, G. scAlign: a tool for alignment, integration and rare cell identification from scRNA-seq data. Genome Biol. 20, 166 (2019).","DOI":"10.1186\/s13059-019-1766-4"},{"key":"1506_CR46","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.tins.2010.09.005","volume":"34","author":"TS Kilduff","year":"2011","unstructured":"Kilduff, T. S., Cauli, B. & Gerashchenko, D. Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation? Trends Neurosci. 34, 10\u201319 (2011).","journal-title":"Trends Neurosci."},{"key":"1506_CR47","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1097\/00001756-199510020-00012","volume":"6","author":"PV Belichenko","year":"1995","unstructured":"Belichenko, P. V., Vogt Weisenhorn, D. M., Mykl\u00f3ssy, J. & Celio, M. R. Calretinin-positive Cajal-Retzius cells persist in the adult human neocortex. Neuroreport 6, 1869\u20131874 (1995).","journal-title":"Neuroreport"},{"key":"1506_CR48","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1093\/cercor\/bht243","volume":"25","author":"SA Sorensen","year":"2015","unstructured":"Sorensen, S. A. et al. Correlated gene expression and target specificity demonstrate excitatory projection neuron diversity. Cereb. Cortex 25, 433\u2013449 (2015).","journal-title":"Cereb. Cortex"},{"key":"1506_CR49","doi-asserted-by":"publisher","DOI":"10.1101\/229815","author":"Y Lin","year":"2017","unstructured":"Lin, Y. et al. Evaluating stably expressed genes in single cells. Preprint at https:\/\/doi.org\/10.1101\/229815 (2018).","journal-title":"bioRxiv"},{"key":"1506_CR50","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nature10524","volume":"478","author":"C Colantuoni","year":"2011","unstructured":"Colantuoni, C. et al. Temporal dynamics and genetic control of transcription in the human prefrontal cortex. Nature 478, 519\u2013523 (2011).","journal-title":"Nature"},{"key":"1506_CR51","doi-asserted-by":"publisher","first-page":"20150140","DOI":"10.1098\/rstb.2015.0140","volume":"371","author":"NM Foley","year":"2016","unstructured":"Foley, N. M., Springer, M. S. & Teeling, E. C. Mammal madness: is the mammal tree of life not yet resolved? Phil. Trans. R. Soc. Lond. B 371, 20150140 (2016).","journal-title":"Phil. Trans. R. Soc. Lond. B"},{"key":"1506_CR52","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/npp.2008.173","volume":"34","author":"A Markou","year":"2009","unstructured":"Markou, A., Chiamulera, C., Geyer, M. A., Tricklebank, M. & Steckler, T. Removing obstacles in neuroscience drug discovery: the future path for animal models. Neuropsychopharmacology 34, 74\u201389 (2009).","journal-title":"Neuropsychopharmacology"},{"key":"1506_CR53","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/nn.2647","volume":"13","author":"EJ Nestler","year":"2010","unstructured":"Nestler, E. J. & Hyman, S. E. Animal models of neuropsychiatric disorders. Nat. Neurosci. 13, 1161\u20131169 (2010).","journal-title":"Nat. Neurosci."},{"key":"1506_CR54","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1023\/A:1024130211265","volume":"31","author":"J DeFelipe","year":"2002","unstructured":"DeFelipe, J., Alonso-Nanclares, L. & Arellano, J. I. Microstructure of the neocortex: comparative aspects. J. Neurocytol. 31, 299\u2013316 (2002).","journal-title":"J. Neurocytol."},{"key":"1506_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/1875036201307010001","volume":"7","author":"E Aronesty","year":"2013","unstructured":"Aronesty, E. Comparison of sequencing utility programs. Open Bioinform. J. 7, 1\u20138 (2013).","journal-title":"Open Bioinform. J."},{"key":"1506_CR56","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15\u201321 (2013).","journal-title":"Bioinformatics"},{"key":"1506_CR57","doi-asserted-by":"publisher","first-page":"e1003118","DOI":"10.1371\/journal.pcbi.1003118","volume":"9","author":"M Lawrence","year":"2013","unstructured":"Lawrence, M. et al. Software for computing and annotating genomic ranges. PLOS Comput. Biol. 9, e1003118 (2013).","journal-title":"PLOS Comput. Biol."},{"key":"1506_CR58","doi-asserted-by":"publisher","first-page":"D1251","DOI":"10.1093\/nar\/gkv1003","volume":"44","author":"SE Calvo","year":"2016","unstructured":"Calvo, S. E., Clauser, K. R. & Mootha, V. K. MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins. Nucleic Acids Res. 44, D1251\u2013D1257 (2016).","journal-title":"Nucleic Acids Res."},{"key":"1506_CR59","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1073\/pnas.0605965104","volume":"104","author":"S Fortunato","year":"2007","unstructured":"Fortunato, S. & Barth\u00e9lemy, M. Resolution limit in community detection. Proc. Natl Acad. Sci. USA 104, 36\u201341 (2007).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1506_CR60","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder, P. & Horvath, S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9, 559 (2008).","journal-title":"BMC Bioinformatics"},{"key":"1506_CR61","doi-asserted-by":"publisher","first-page":"R40","DOI":"10.1093\/hmg\/ddy100","volume":"27","author":"BD Aevermann","year":"2018","unstructured":"Aevermann, B. D. et al. Cell type discovery using single-cell transcriptomics: implications for ontological representation. Hum. Mol. Genet. 27, R40\u2013R47 (2018).","journal-title":"Hum. Mol. Genet."},{"key":"1506_CR62","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/bioinformatics\/bti042","volume":"21","author":"I Yanai","year":"2005","unstructured":"Yanai, I. et al. Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification. Bioinformatics 21, 650\u2013659 (2005).","journal-title":"Bioinformatics"},{"key":"1506_CR63","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/nature05453","volume":"445","author":"ES Lein","year":"2007","unstructured":"Lein, E. S. et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168\u2013176 (2007).","journal-title":"Nature"},{"key":"1506_CR64","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1038\/nprot.2013.109","volume":"8","author":"A Lyubimova","year":"2013","unstructured":"Lyubimova, A. et al. Single-molecule mRNA detection and counting in mammalian tissue. Nat. Protocols 8, 1743\u20131758 (2013).","journal-title":"Nat. Protocols"},{"key":"1506_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03282-0","volume":"9","author":"M Crow","year":"2018","unstructured":"Crow, M., Paul, A., Ballouz, S., Huang, Z. J. & Gillis, J. Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor. Nat. Commun. 9, 884 (2018).","journal-title":"Nat. Commun."},{"key":"1506_CR66","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/cgf.12893","volume":"35","author":"T H\u00f6llt","year":"2016","unstructured":"H\u00f6llt, T. et al. Cytosplore: Interactive immune cell phenotyping for large single-cell datasets. Comput. Graph. Forum 35, 171\u2013180 (2016).","journal-title":"Comput. Graph. Forum"},{"key":"1506_CR67","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1109\/TVCG.2017.2744318","volume":"24","author":"T H\u00f6llt","year":"2018","unstructured":"H\u00f6llt, T. et al. CyteGuide: Visual guidance for hierarchical single-cell analysis. IEEE Trans. Vis. Comput. Graph. 24, 739\u2013748 (2018).","journal-title":"IEEE Trans. Vis. Comput. Graph."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-019-1506-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-019-1506-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-019-1506-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T04:12:25Z","timestamp":1732767145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-019-1506-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,21]]},"references-count":67,"journal-issue":{"issue":"7772","published-print":{"date-parts":[[2019,9,5]]}},"alternative-id":["1506"],"URL":"https:\/\/doi.org\/10.1038\/s41586-019-1506-7","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736463800.793571577","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/384826","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,21]]},"assertion":[{"value":"4 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}