{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T15:42:22Z","timestamp":1794411742985,"version":"4.9.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"7773","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2019,9,12]]},"DOI":"10.1038\/s41586-019-1536-1","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T18:03:00Z","timestamp":1567620180000},"page":"271-275","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Maternal vitamin C regulates reprogramming of DNA methylation and germline development"],"prefix":"10.1038","volume":"573","author":[{"given":"Stephanie P.","family":"DiTroia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Percharde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Justine","family":"Guerquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Collignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin T.","family":"Ebata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Mesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swetha","family":"Mahesula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michalis","family":"Agathocleous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana J.","family":"Laird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Livera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Ramalho-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"issue":"Suppl.","key":"1536_CR1","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","volume":"23","author":"DJP Barker","year":"2004","unstructured":"Barker, D. J. P. The developmental origins of adult disease. J. Am. Coll. Nutr. 23, 588S\u2013595S (2004).","journal-title":"J. Am. Coll. Nutr."},{"key":"1536_CR2","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1289\/ehp.1204934","volume":"120","author":"K Boekelheide","year":"2012","unstructured":"Boekelheide, K. et al. Predicting later-life outcomes of early-life exposures. Environ. Health Perspect. 120, 1353\u20131361 (2012).","journal-title":"Environ. Health Perspect."},{"key":"1536_CR3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.molcel.2012.11.001","volume":"48","author":"S Seisenberger","year":"2012","unstructured":"Seisenberger, S. et al. The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells. Mol. Cell 48, 849\u2013862 (2012).","journal-title":"Mol. Cell"},{"key":"1536_CR4","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.1229277","volume":"339","author":"JA Hackett","year":"2013","unstructured":"Hackett, J. A. et al. Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science 339, 448\u2013452 (2013).","journal-title":"Science"},{"key":"1536_CR5","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.cell.2015.05.012","volume":"161","author":"S Gkountela","year":"2015","unstructured":"Gkountela, S. et al. DNA demethylation dynamics in the human prenatal germline. Cell 161, 1425\u20131436 (2015).","journal-title":"Cell"},{"key":"1536_CR6","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2015.05.015","volume":"161","author":"F Guo","year":"2015","unstructured":"Guo, F. et al. The transcriptome and DNA methylome landscapes of human primordial germ cells. Cell 161, 1437\u20131452 (2015).","journal-title":"Cell"},{"key":"1536_CR7","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.cell.2015.04.053","volume":"161","author":"WWC Tang","year":"2015","unstructured":"Tang, W. W. C. et al. A unique gene regulatory network resets the human germline epigenome for development. Cell 161, 1453\u20131467 (2015).","journal-title":"Cell"},{"key":"1536_CR8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature11709","volume":"492","author":"S Yamaguchi","year":"2012","unstructured":"Yamaguchi, S. et al. Tet1 controls meiosis by regulating meiotic gene expression. Nature 492, 443\u2013447 (2012).","journal-title":"Nature"},{"key":"1536_CR9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nature12805","volume":"504","author":"S Yamaguchi","year":"2013","unstructured":"Yamaguchi, S., Shen, L., Liu, Y., Sendler, D. & Zhang, Y. Role of Tet1 in erasure of genomic imprinting. Nature 504, 460\u2013464 (2013).","journal-title":"Nature"},{"key":"1536_CR10","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nature06714","volume":"452","author":"P Hajkova","year":"2008","unstructured":"Hajkova, P. et al. Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature 452, 877\u2013881 (2008).","journal-title":"Nature"},{"key":"1536_CR11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature12362","volume":"500","author":"K Blaschke","year":"2013","unstructured":"Blaschke, K. et al. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature 500, 222\u2013226 (2013).","journal-title":"Nature"},{"key":"1536_CR12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature13981","volume":"518","author":"BW Carey","year":"2014","unstructured":"Carey, B. W., Finley, L. W. S., Cross, J. R., Allis, C. D. & Thompson, C. B. Intracellular \u03b1-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature 518, 413\u2013416 (2014).","journal-title":"Nature"},{"key":"1536_CR13","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1074\/jbc.M113.524140","volume":"289","author":"Q Zhang","year":"2014","unstructured":"Zhang, Q. et al. Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked \u03b2-N-acetylglucosamine transferase (OGT). J. Biol. Chem. 289, 5986\u20135996 (2014).","journal-title":"J. Biol. Chem."},{"key":"1536_CR14","doi-asserted-by":"crossref","first-page":"10396","DOI":"10.1021\/ja4028346","volume":"135","author":"R Yin","year":"2013","unstructured":"Yin, R. et al. Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. J. Am. Chem. Soc. 135, 10396\u201310403 (2013).","journal-title":"J. Am. Chem. Soc."},{"key":"1536_CR15","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1101\/gad.179184.111","volume":"25","author":"H Wu","year":"2011","unstructured":"Wu, H. & Zhang, Y. Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev. 25, 2436\u20132452 (2011).","journal-title":"Genes Dev."},{"key":"1536_CR16","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1073\/pnas.97.2.841","volume":"97","author":"N Maeda","year":"2000","unstructured":"Maeda, N. et al. Aortic wall damage in mice unable to synthesize ascorbic acid. Proc. Natl Acad. Sci. USA 97, 841\u2013846 (2000).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1536_CR17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0925-4773(02)00087-4","volume":"115","author":"PE Szab\u00f3","year":"2002","unstructured":"Szab\u00f3, P. E., H\u00fcbner, K., Sch\u00f6ler, H. & Mann, J. R. Allele-specific expression of imprinted genes in mouse migratory primordial germ cells. Mech. Dev. 115, 157\u2013160 (2002).","journal-title":"Mech. Dev."},{"key":"1536_CR18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nature25964","volume":"555","author":"PWS Hill","year":"2018","unstructured":"Hill, P. W. S. et al. Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte. Nature 555, 392\u2013396 (2018).","journal-title":"Nature"},{"key":"1536_CR19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1101\/gr.148023.112","volume":"23","author":"H Kobayashi","year":"2013","unstructured":"Kobayashi, H. et al. High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice. Genome Res. 23, 616\u2013627 (2013).","journal-title":"Genome Res."},{"key":"1536_CR20","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1242\/dev.093229","volume":"140","author":"R Ohno","year":"2013","unstructured":"Ohno, R. et al. A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells. Development 140, 2892\u20132903 (2013).","journal-title":"Development"},{"key":"1536_CR21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13072-017-0143-3","volume":"10","author":"KT Ebata","year":"2017","unstructured":"Ebata, K. T. et al. Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a\/b. Epigenetics Chromatin 10, 36 (2017).","journal-title":"Epigenetics Chromatin"},{"key":"1536_CR22","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1242\/dev.005611","volume":"134","author":"Y Seki","year":"2007","unstructured":"Seki, Y. et al. Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice. Development 134, 2627\u20132638 (2007).","journal-title":"Development"},{"key":"1536_CR23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2174\/138920211796429736","volume":"12","author":"G Drouin","year":"2011","unstructured":"Drouin, G., Godin, J.-R. & Pag\u00e9, B. The genetics of vitamin C loss in vertebrates. Curr. Genomics 12, 371\u2013378 (2011).","journal-title":"Curr. Genomics"},{"key":"1536_CR24","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/tx700198a","volume":"21","author":"K Salnikow","year":"2008","unstructured":"Salnikow, K. & Zhitkovich, A. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem. Res. Toxicol. 21, 28\u201344 (2008).","journal-title":"Chem. Res. Toxicol."},{"key":"1536_CR25","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2174\/1568026013394831","volume":"1","author":"N Ercal","year":"2001","unstructured":"Ercal, N., Gurer-Orhan, H. & Aykin-Burns, N. Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr. Top. Med. Chem. 1, 529\u2013539 (2001).","journal-title":"Curr. Top. Med. Chem."},{"key":"1536_CR26","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1258\/0007142991902565","volume":"55","author":"CE Cross","year":"1999","unstructured":"Cross, C. E., Traber, M., Eiserich, J. & van der Vliet, A. Micronutrient antioxidants and smoking. Br. Med. Bull. 55, 691\u2013704 (1999).","journal-title":"Br. Med. Bull."},{"key":"1536_CR27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0300-483X(94)90166-X","volume":"92","author":"NZ Alsharif","year":"1994","unstructured":"Alsharif, N. Z., Lawson, T. & Stohs, S. J. Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by the aryl hydrocarbon (Ah) receptor complex. Toxicology 92, 39\u201351 (1994).","journal-title":"Toxicology"},{"key":"1536_CR28","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0006-2952(03)00157-6","volume":"66","author":"F Matsumura","year":"2003","unstructured":"Matsumura, F. On the significance of the role of cellular stress response reactions in the toxic actions of dioxin. Biochem. Pharmacol. 66, 527\u2013540 (2003).","journal-title":"Biochem. Pharmacol."},{"key":"1536_CR29","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1089\/ars.2010.3492","volume":"15","author":"AR Cyr","year":"2011","unstructured":"Cyr, A. R. & Domann, F. E. The redox basis of epigenetic modifications: from mechanisms to functional consequences. Antioxid. Redox Signal. 15, 551\u2013589 (2011).","journal-title":"Antioxid. Redox Signal."},{"key":"1536_CR30","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4110\/in.2012.12.1.18","volume":"12","author":"H Kim","year":"2012","unstructured":"Kim, H. et al. The analysis of vitamin C concentration in organs of Gulo\n\u2212\/\u2212 mice upon vitamin C withdrawal. Immune Netw. 12, 18\u201326 (2012).","journal-title":"Immune Netw."},{"key":"1536_CR31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1530\/jrf.0.0210563","volume":"21","author":"LM Franks","year":"1970","unstructured":"Franks, L. M. & Payne, J. The influence of age on reproductive capacity in C57BL mice. J. Reprod. Fertil. 21, 563\u2013565 (1970).","journal-title":"J. Reprod. Fertil."},{"key":"1536_CR32","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature23876","volume":"549","author":"M Agathocleous","year":"2017","unstructured":"Agathocleous, M. et al. Ascorbate regulates haematopoietic stem cell function and leukaemogenesis. Nature 549, 476\u2013481 (2017).","journal-title":"Nature"},{"key":"1536_CR33","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ydbio.2010.08.002","volume":"346","author":"M-J Guerquin","year":"2010","unstructured":"Guerquin, M.-J. et al. New testicular mechanisms involved in the prevention of fetal meiotic initiation in mice. Dev. Biol. 346, 320\u2013330 (2010).","journal-title":"Dev. Biol."},{"key":"1536_CR34","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1242\/jcs.189910","volume":"129","author":"R Arora","year":"2016","unstructured":"Arora, R. et al. Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary. J. Cell Sci. 129, 2493\u20132499 (2016).","journal-title":"J. Cell Sci."},{"key":"1536_CR35","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10324","volume":"7","author":"E Abby","year":"2016","unstructured":"Abby, E. et al. Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts. Nat. Commun. 7, 10324 (2016).","journal-title":"Nat. Commun."},{"key":"1536_CR36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ydbio.2015.04.006","volume":"403","author":"M Faire","year":"2015","unstructured":"Faire, M. et al. Follicle dynamics and global organization in the intact mouse ovary. Dev. Biol. 403, 69\u201379 (2015).","journal-title":"Dev. Biol."},{"key":"1536_CR37","volume":"14","author":"D Kim","year":"2013","unstructured":"Kim, D. et al. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. 14, R36 (2013).","journal-title":"Genome Biol."},{"key":"1536_CR38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders, S., Pyl, P. T. & Huber, W. HTSeq\u2014a Python framework to work with high-throughput sequencing data. Bioinformatics 31, 166\u2013169 (2015).","journal-title":"Bioinformatics"},{"key":"1536_CR39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nmeth.3252","volume":"12","author":"W Huber","year":"2015","unstructured":"Huber, W. et al. Orchestrating high-throughput genomic analysis with Bioconductor. Nat. Methods 12, 115\u2013121 (2015).","journal-title":"Nat. Methods"},{"key":"1536_CR40","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."},{"key":"1536_CR41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W Huang","year":"2009","unstructured":"Huang, W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protocols 4, 44\u201357 (2009).","journal-title":"Nat. Protocols"},{"key":"1536_CR42","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545\u201315550 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1536_CR43","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/nature07107","volume":"454","author":"A Meissner","year":"2008","unstructured":"Meissner, A. et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454, 766\u2013770 (2008).","journal-title":"Nature"},{"key":"1536_CR44","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1101\/gr.161679.113","volume":"23","author":"H Guo","year":"2013","unstructured":"Guo, H. et al. Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing. Genome Res. 23, 2126\u20132135 (2013).","journal-title":"Genome Res."},{"key":"1536_CR45","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","volume":"27","author":"F Krueger","year":"2011","unstructured":"Krueger, F. & Andrews, S. R. Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Bioinformatics 27, 1571\u20131572 (2011).","journal-title":"Bioinformatics"},{"key":"1536_CR46","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/bioinformatics\/btt263","volume":"29","author":"K Hebestreit","year":"2013","unstructured":"Hebestreit, K., Dugas, M. & Klein, H.-U. Detection of significantly differentially methylated regions in targeted bisulfite sequencing data. Bioinformatics 29, 1647\u20131653 (2013).","journal-title":"Bioinformatics"},{"key":"1536_CR47","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","volume":"28","author":"CY McLean","year":"2010","unstructured":"McLean, C. Y. et al. GREAT improves functional interpretation of cis-regulatory regions. Nat. Biotechnol. 28, 495\u2013501 (2010).","journal-title":"Nat. Biotechnol."},{"key":"1536_CR48","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature09934","volume":"473","author":"H Wu","year":"2011","unstructured":"Wu, H. et al. Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature 473, 389\u2013393 (2011).","journal-title":"Nature"},{"key":"1536_CR49","volume":"16","author":"Z Li","year":"2015","unstructured":"Li, Z. et al. Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells. Genome Biol. 16, 115 (2015).","journal-title":"Genome Biol."},{"key":"1536_CR50","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.cell.2019.03.014","volume":"177","author":"SJ Hainer","year":"2019","unstructured":"Hainer, S. J., Bo\u0161kovi\u0107, A., McCannel, K. N., Rando, O. J. & Fazzio, T. G. Profiling of pluripotency factors in stem cells and early embryos. Cell 177, 1319\u20131329 (2019).","journal-title":"Cell"},{"key":"1536_CR51","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/nprot.2018.015","volume":"13","author":"PJ Skene","year":"2018","unstructured":"Skene, P. J., Henikoff, J. G. & Henikoff, S. Targeted in situ genome-wide profiling with high efficiency for low cell numbers. Nat. Protocols 13, 1006\u20131019 (2018).","journal-title":"Nat. Protocols"},{"key":"1536_CR52","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.celrep.2017.05.036","volume":"19","author":"M Percharde","year":"2017","unstructured":"Percharde, M., Wong, P. & Ramalho-Santos, M. Global hypertranscription in the mouse embryonic germline. Cell Reports 19, 1987\u20131996 (2017).","journal-title":"Cell Reports"},{"key":"1536_CR53","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015).","journal-title":"Nucleic Acids Res."}],"updated-by":[{"DOI":"10.1038\/s41586-019-1699-9","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41586-019-1536-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-019-1536-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-019-1536-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T21:58:53Z","timestamp":1684619933000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-019-1536-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,4]]},"references-count":53,"journal-issue":{"issue":"7773","published-print":{"date-parts":[[2019,9,12]]}},"alternative-id":["1536"],"URL":"https:\/\/doi.org\/10.1038\/s41586-019-1536-1","relation":{"correction":[{"id-type":"doi","id":"10.1038\/s41586-019-1699-9","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,4]]},"assertion":[{"value":"2 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2019","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"An Amendment to this paper has been published and can be accessed via a link at the top of the paper.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}