{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:45:03Z","timestamp":1793731503194,"version":"4.6.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"7791","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2020,1,23]]},"DOI":"10.1038\/s41586-019-1898-4","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T19:03:04Z","timestamp":1578510184000},"page":"543-548","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["Microbiota-targeted maternal antibodies protect neonates from enteric infection"],"prefix":"10.1038","volume":"577","author":[{"given":"Wen","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Caro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gazzaniga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Stefanetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungwhan","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Mekalanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis L.","family":"Kasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"1898_CR1","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1586\/1744666X.2014.942288","volume":"10","author":"S Basha","year":"2014","unstructured":"Basha, S., Surendran, N. & Pichichero, M. Immune responses in neonates. Expert Rev. Clin. Immunol. 10, 1171\u20131184 (2014).","journal-title":"Expert Rev. Clin. Immunol."},{"key":"1898_CR2","doi-asserted-by":"publisher","first-page":"20143085","DOI":"10.1098\/rspb.2014.3085","volume":"282","author":"AK Simon","year":"2015","unstructured":"Simon, A. K., Hollander, G. A. & McMichael, A. Evolution of the immune system in humans from infancy to old age. Proc. R. Soc. B 282, 20143085 (2015).","journal-title":"Proc. R. Soc. B"},{"key":"1898_CR3","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/ni.2608","volume":"14","author":"N Kamada","year":"2013","unstructured":"Kamada, N., Chen, G. Y., Inohara, N. & N\u00fa\u00f1ez, G. Control of pathogens and pathobionts by the gut microbiota. Nat. Immunol. 14, 685\u2013690 (2013).","journal-title":"Nat. Immunol."},{"key":"1898_CR4","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1111\/j.1399-3038.2005.00332.x","volume":"16","author":"CB Carbonare","year":"2005","unstructured":"Carbonare, C. B., Carbonare, S. B. & Carneiro-Sampaio, M. M. S. Secretory immunoglobulin A obtained from pooled human colostrum and milk for oral passive immunization. Pediatr. Allergy Immunol. 16, 574\u2013581 (2005).","journal-title":"Pediatr. Allergy Immunol."},{"key":"1898_CR5","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1053\/siny.2002.0124","volume":"7","author":"LAR Hanson","year":"2002","unstructured":"Hanson, L. A. R. & Korotkova, M. The role of breastfeeding in prevention of neonatal infection. Semin. Neonatol. 7, 275\u2013281 (2002).","journal-title":"Semin. Neonatol."},{"key":"1898_CR6","doi-asserted-by":"publisher","first-page":"4989","DOI":"10.1128\/IAI.60.12.4989-4994.1992","volume":"60","author":"LC Madoff","year":"1992","unstructured":"Madoff, L. C., Michel, J. L., Gong, E. W., Rodewald, A. K. & Kasper, D. L. Protection of neonatal mice from group B streptococcal infection by maternal immunization with beta C protein. Infect. Immun. 60, 4989\u20134994 (1992).","journal-title":"Infect. Immun."},{"key":"1898_CR7","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1056\/NEJMoa0708630","volume":"359","author":"K Zaman","year":"2008","unstructured":"Zaman, K. et al. Effectiveness of maternal influenza immunization in mothers and infants. N. Engl. J. Med. 359, 1555\u20131564 (2008).","journal-title":"N. Engl. J. Med."},{"key":"1898_CR8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1093\/infdis\/171.1.99","volume":"171","author":"JA Englund","year":"1995","unstructured":"Englund, J. A. et al. Transplacental antibody transfer following maternal immunization with polysaccharide and conjugate Haemophilus influenzae type b vaccines. J. Infect. Dis. 171, 99\u2013105 (1995).","journal-title":"J. Infect. Dis."},{"key":"1898_CR9","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1146\/annurev-immunol-032713-120140","volume":"33","author":"JF Kearney","year":"2015","unstructured":"Kearney, J. F., Patel, P., Stefanov, E. K. & King, R. G. Natural antibody repertoires: development and functional role in inhibiting allergic airway disease. Annu. Rev. Immunol. 33, 475\u2013504 (2015).","journal-title":"Annu. Rev. Immunol."},{"key":"1898_CR10","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nri.2017.58","volume":"17","author":"AJ Macpherson","year":"2017","unstructured":"Macpherson, A. J., de Ag\u00fcero, M. G. & Ganal-Vonarburg, S. C. How nutrition and the maternal microbiota shape the neonatal immune system. Nat. Rev. Immunol. 17, 508\u2013517 (2017).","journal-title":"Nat. Rev. Immunol."},{"key":"1898_CR11","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1084\/jem.20171761","volume":"215","author":"Y Chen","year":"2018","unstructured":"Chen, Y. et al. Microbial symbionts regulate the primary Ig repertoire. J. Exp. Med. 215, 1397\u20131415 (2018).","journal-title":"J. Exp. Med."},{"key":"1898_CR12","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1093\/infdis\/168.3.647","volume":"168","author":"JA Englund","year":"1993","unstructured":"Englund, J. A. et al. Maternal immunization with influenza or tetanus toxoid vaccine for passive antibody protection in young infants. J. Infect. Dis. 168, 647\u2013656 (1993).","journal-title":"J. Infect. Dis."},{"key":"1898_CR13","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.1084\/jem.188.12.2381","volume":"188","author":"M Boes","year":"1998","unstructured":"Boes, M., Prodeus, A. P., Schmidt, T., Carroll, M. C. & Chen, J. A critical role of natural immunoglobulin M in immediate defense against systemic bacterial infection. J. Exp. Med. 188, 2381\u20132386 (1998).","journal-title":"J. Exp. Med."},{"key":"1898_CR14","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1126\/science.286.5447.2156","volume":"286","author":"AF Ochsenbein","year":"1999","unstructured":"Ochsenbein, A. F. et al. Control of early viral and bacterial distribution and disease by natural antibodies. Science 286, 2156\u20132159 (1999).","journal-title":"Science"},{"key":"1898_CR15","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1084\/jem.192.2.271","volume":"192","author":"N Baumgarth","year":"2000","unstructured":"Baumgarth, N. et al. B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J. Exp. Med. 192, 271\u2013280 (2000).","journal-title":"J. Exp. Med."},{"key":"1898_CR16","doi-asserted-by":"publisher","first-page":"3487","DOI":"10.1128\/JVI.02128-06","volume":"81","author":"JP Jayasekera","year":"2007","unstructured":"Jayasekera, J. P., Moseman, E. A. & Carroll, M. C. Natural antibody and complement mediate neutralization of influenza virus in the absence of prior immunity. J. Virol. 81, 3487\u20133494 (2007).","journal-title":"J. Virol."},{"key":"1898_CR17","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.chom.2007.01.002","volume":"1","author":"ZH Zhou","year":"2007","unstructured":"Zhou, Z. H. et al. The broad antibacterial activity of the natural antibody repertoire is due to polyreactive antibodies. Cell Host Microbe 1, 51\u201361 (2007).","journal-title":"Cell Host Microbe"},{"key":"1898_CR18","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.chom.2018.12.015","volume":"25","author":"G Caballero-Flores","year":"2019","unstructured":"Caballero-Flores, G. et al. Maternal immunization confers protection to the offspring against an attaching and effacing pathogen through delivery of IgG in breast milk. Cell Host Microbe 25, 313\u2013323 (2019).","journal-title":"Cell Host Microbe"},{"key":"1898_CR19","doi-asserted-by":"publisher","first-page":"985646","DOI":"10.1155\/2012\/985646","volume":"2012","author":"P Palmeira","year":"2012","unstructured":"Palmeira, P., Quinello, C., Silveira-Lessa, A. L., Zago, C. A. & Carneiro-Sampaio, M. IgG placental transfer in healthy and pathological pregnancies. Clin. Dev. Immunol. 2012, 985646 (2012).","journal-title":"Clin. Dev. Immunol."},{"key":"1898_CR20","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1128\/IAI.01493-07","volume":"76","author":"A Masuda","year":"2008","unstructured":"Masuda, A. et al. Fc\u03b3 receptor regulation of Citrobacter rodentium infection. Infect. Immun. 76, 1728\u20131737 (2008).","journal-title":"Infect. Immun."},{"key":"1898_CR21","doi-asserted-by":"publisher","first-page":"4595","DOI":"10.4049\/jimmunol.1403014","volume":"194","author":"M Pyzik","year":"2015","unstructured":"Pyzik, M., Rath, T., Lencer, W. I., Baker, K. & Blumberg, R. S. FcRn: the architect behind the immune and nonimmune functions of IgG and albumin. J. Immunol. 194, 4595\u20134603 (2015).","journal-title":"J. Immunol."},{"key":"1898_CR22","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1046\/j.1365-2567.1997.00326.x","volume":"92","author":"EJ Israel","year":"1997","unstructured":"Israel, E. J. et al. Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells. Immunology 92, 69\u201374 (1997).","journal-title":"Immunology"},{"key":"1898_CR23","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","volume":"382","author":"KL Kotloff","year":"2013","unstructured":"Kotloff, K. L. et al. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case\u2013control study. Lancet 382, 209\u2013222 (2013).","journal-title":"Lancet"},{"key":"1898_CR24","doi-asserted-by":"publisher","first-page":"6783","DOI":"10.1016\/j.vaccine.2017.07.036","volume":"35","author":"KL Kotloff","year":"2017","unstructured":"Kotloff, K. L. et al. Global burden of diarrheal diseases among children in developing countries: incidence, etiology, and insights from new molecular diagnostic techniques. Vaccine 35, 6783\u20136789 (2017).","journal-title":"Vaccine"},{"key":"1898_CR25","doi-asserted-by":"publisher","first-page":"e568","DOI":"10.1016\/S2214-109X(19)30076-2","volume":"7","author":"KL Kotloff","year":"2019","unstructured":"Kotloff, K. L. et al. The incidence, aetiology, and adverse clinical consequences of less severe diarrhoeal episodes among infants and children residing in low-income and middle-income countries: a 12-month case\u2013control study as a follow-on to the Global Enteric Multicenter Study (GEMS). Lancet Glob. Health 7, e568\u2013e584 (2019).","journal-title":"Lancet Glob. Health"},{"key":"1898_CR26","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1128\/CMR.18.3.465-483.2005","volume":"18","author":"F Qadri","year":"2005","unstructured":"Qadri, F., Svennerholm, A.-M., Faruque, A. S. G. & Sack, R. B. Enterotoxigenic Escherichia coli in developing countries: epidemiology, microbiology, clinical features, treatment, and prevention. Clin. Microbiol. Rev. 18, 465\u2013483 (2005).","journal-title":"Clin. Microbiol. Rev."},{"key":"1898_CR27","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/S0140-6736(04)15599-2","volume":"363","author":"N Thapar","year":"2004","unstructured":"Thapar, N. & Sanderson, I. R. Diarrhoea in children: an interface between developing and developed countries. Lancet 363, 641\u2013653 (2004).","journal-title":"Lancet"},{"key":"1898_CR28","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1586\/14760584.2016.1159135","volume":"15","author":"D Skurnik","year":"2016","unstructured":"Skurnik, D., Cywes-Bentley, C. & Pier, G. B. The exceptionally broad-based potential of active and passive vaccination targeting the conserved microbial surface polysaccharide PNAG. Expert Rev. Vaccines 15, 1041\u20131053 (2016).","journal-title":"Expert Rev. Vaccines"},{"key":"1898_CR29","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1084\/jem.20180977","volume":"215","author":"S Le Gallou","year":"2018","unstructured":"Le Gallou, S. et al. A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses. J. Exp. Med. 215, 2035\u20132053 (2018).","journal-title":"J. Exp. Med."},{"key":"1898_CR30","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.chom.2018.01.005","volume":"23","author":"JR Wilmore","year":"2018","unstructured":"Wilmore, J. R. et al. Commensal microbes induce serum IgA responses that protect against polymicrobial sepsis. Cell Host Microbe 23, 302\u2013311 (2018).","journal-title":"Cell Host Microbe"},{"key":"1898_CR31","doi-asserted-by":"publisher","first-page":"5279","DOI":"10.1128\/IAI.61.12.5279-5285.1993","volume":"61","author":"FM Apter","year":"1993","unstructured":"Apter, F. M. et al. Analysis of the roles of antilipopolysaccharide and anti-cholera toxin immunoglobulin A (IgA) antibodies in protection against Vibrio cholerae and cholera toxin by use of monoclonal IgA antibodies in vivo. Infect. Immun. 61, 5279\u20135285 (1993).","journal-title":"Infect. Immun."},{"key":"1898_CR32","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1128\/IAI.60.5.1786-1792.1992","volume":"60","author":"P Michetrti","year":"1992","unstructured":"Michetrti, P., Mahan, M. J., Slauch, J. M., Mekalanos, J. J. & Neutra, M. R. Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium. Infect. Immun. 60, 1786\u20131792 (1992).","journal-title":"Infect. Immun."},{"key":"1898_CR33","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature22058","volume":"544","author":"K Moor","year":"2017","unstructured":"Moor, K. et al. High-avidity IgA protects the intestine by enchaining growing bacteria. Nature 544, 498\u2013502 (2017).","journal-title":"Nature"},{"key":"1898_CR34","first-page":"222","volume":"2","author":"A Stuebe","year":"2009","unstructured":"Stuebe, A. The risks of not breastfeeding for mothers and infants. Rev. Obstet. Gynecol. 2, 222\u2013231 (2009).","journal-title":"Rev. Obstet. Gynecol."},{"key":"1898_CR35","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4315\/0362-028X-46.1.4","volume":"46","author":"SJ Goldsmith","year":"1983","unstructured":"Goldsmith, S. J., Dickson, J. S., Barnhart, H. M., Toledo, R. T. & Eiten-Miller, R. R. IgA, IgG, IgM and lactoferrin contents of human milk during early lactation and the effect of processing and storage. J. Food Prot. 46, 4\u20137 (1983).","journal-title":"J. Food Prot."},{"key":"1898_CR36","doi-asserted-by":"publisher","first-page":"9555","DOI":"10.1128\/JVI.05174-11","volume":"85","author":"GG Fouda","year":"2011","unstructured":"Fouda, G. G. et al. HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies. J. Virol. 85, 9555\u20139567 (2011).","journal-title":"J. Virol."},{"key":"1898_CR37","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1172\/JCI6968","volume":"104","author":"BL Dickinson","year":"1999","unstructured":"Dickinson, B. L. et al. Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. J. Clin. Invest. 104, 903\u2013911 (1999).","journal-title":"J. Clin. Invest."},{"key":"1898_CR38","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/intimm\/dxx025","volume":"29","author":"S Bournazos","year":"2017","unstructured":"Bournazos, S. & Ravetch, J. V. Diversification of IgG effector functions. Int. Immunol. 29, 303\u2013310 (2017).","journal-title":"Int. Immunol."},{"key":"1898_CR39","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1146\/annurev.iy.12.040194.000431","volume":"12","author":"KE Mostov","year":"1994","unstructured":"Mostov, K. E. Transepithelial transport of immunoglobulins. Annu. Rev. Immunol. 12, 63\u201384 (1994).","journal-title":"Annu. Rev. Immunol."},{"key":"1898_CR40","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.immuni.2004.05.007","volume":"20","author":"M Yoshida","year":"2004","unstructured":"Yoshida, M. et al. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20, 769\u2013783 (2004).","journal-title":"Immunity"},{"key":"1898_CR41","doi-asserted-by":"publisher","first-page":"4516","DOI":"10.1073\/pnas.1000080107","volume":"108","author":"JG Caporaso","year":"2011","unstructured":"Caporaso, J. G. et al. Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proc. Natl Acad. Sci. USA 108, 4516\u20134522 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"1898_CR42","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","volume":"37","author":"E Bolyen","year":"2019","unstructured":"Bolyen, E. et al. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat. Biotechnol. 37, 852\u2013857 (2019).","journal-title":"Nat. Biotechnol."},{"key":"1898_CR43","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1128\/AEM.62.2.625-630.1996","volume":"62","author":"MT Suzuki","year":"1996","unstructured":"Suzuki, M. T. & Giovannoni, S. J. Bias caused by template annealing in the amplification of mixtures of 16S rRNA genes by PCR. Appl. Environ. Microbiol. 62, 625\u2013630 (1996).","journal-title":"Appl. Environ. Microbiol."},{"key":"1898_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41586-019-1898-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-019-1898-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-019-1898-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T22:01:28Z","timestamp":1684620088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-019-1898-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,8]]},"references-count":44,"journal-issue":{"issue":"7791","published-print":{"date-parts":[[2020,1,23]]}},"alternative-id":["1898"],"URL":"https:\/\/doi.org\/10.1038\/s41586-019-1898-4","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,8]]},"assertion":[{"value":"9 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}