{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T18:12:16Z","timestamp":1794679936854,"version":"4.9.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7802","license":[{"start":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T00:00:00Z","timestamp":1585094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T00:00:00Z","timestamp":1585094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2020,4,9]]},"DOI":"10.1038\/s41586-020-2134-y","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T13:03:11Z","timestamp":1585141391000},"page":"257-262","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":969,"title":["A conserved dendritic-cell regulatory program limits antitumour immunity"],"prefix":"10.1038","volume":"580","author":[{"given":"Barbara","family":"Maier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Leader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven T.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navpreet","family":"Tung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7651-7220","authenticated-orcid":false,"given":"Christie","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"LeBerichel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksey","family":"Chudnovskiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrisha","family":"Maskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-298X","authenticated-orcid":false,"given":"John P.","family":"Finnigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1202-335X","authenticated-orcid":false,"given":"Margaret E.","family":"Kirkling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Reizis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourav","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie Roy","family":"D\u2019Amore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla V.","family":"Rothlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Marron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeeb H.","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ephraim","family":"Kenigsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Merad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,25]]},"reference":[{"key":"2134_CR1","doi-asserted-by":"publisher","first-page":"6643","DOI":"10.1158\/0008-5472.CAN-18-0933","volume":"78","author":"AR S\u00e1nchez-Paulete","year":"2018","unstructured":"S\u00e1nchez-Paulete, A. R. et al. Intratumoral immunotherapy with XCL1 and sFlt3L encoded in recombinant Semliki Forest Virus-derived fosters dendritic cell-mediated T-cell cross-priming. Cancer Res. 78, 6643\u20136654 (2018).","journal-title":"Cancer Res."},{"key":"2134_CR2","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.immuni.2016.03.012","volume":"44","author":"H Salmon","year":"2016","unstructured":"Salmon, H. et al. Expansion and activation of CD103+ dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition. Immunity 44, 924\u2013938 (2016).","journal-title":"Immunity"},{"key":"2134_CR3","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.ccell.2014.09.007","volume":"26","author":"ML Broz","year":"2014","unstructured":"Broz, M. L. et al. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell 26, 638\u2013652 (2014).","journal-title":"Cancer Cell"},{"key":"2134_CR4","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.cell.2017.04.014","volume":"169","author":"Y Lavin","year":"2017","unstructured":"Lavin, Y. et al. Innate immune landscape in early lung adenocarcinoma by paired single-cell analyses. Cell 169, 750\u2013765 (2017).","journal-title":"Cell"},{"key":"2134_CR5","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1084\/jem.20091756","volume":"206","author":"F Ginhoux","year":"2009","unstructured":"Ginhoux, F. et al. The origin and development of nonlymphoid tissue CD103+ DCs. J. Exp. Med. 206, 3115\u20133130 (2009).","journal-title":"J. Exp. Med."},{"key":"2134_CR6","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.immuni.2010.09.012","volume":"33","author":"T Sathaliyawala","year":"2010","unstructured":"Sathaliyawala, T. et al. Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity 33, 597\u2013606 (2010).","journal-title":"Immunity"},{"key":"2134_CR7","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1038\/ni.2370","volume":"13","author":"JC Miller","year":"2012","unstructured":"Miller, J. C. et al. Deciphering the transcriptional network of the dendritic cell lineage. Nat. Immunol. 13, 888\u2013899 (2012).","journal-title":"Nat. Immunol."},{"key":"2134_CR8","first-page":"844","volume":"123","author":"J Idoyaga","year":"2013","unstructured":"Idoyaga, J. et al. Specialized role of migratory dendritic cells in peripheral tolerance induction. J. Clin. Invest. 123, 844\u2013854 (2013).","journal-title":"J. Clin. Invest."},{"key":"2134_CR9","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1146\/annurev.immunol.21.120601.141040","volume":"21","author":"RM Steinman","year":"2003","unstructured":"Steinman, R. M., Hawiger, D. & Nussenzweig, M. C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21, 685\u2013711 (2003).","journal-title":"Annu. Rev. Immunol."},{"key":"2134_CR10","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.immuni.2004.06.014","volume":"21","author":"L Ohl","year":"2004","unstructured":"Ohl, L. et al. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 21, 279\u2013288 (2004).","journal-title":"Immunity"},{"key":"2134_CR11","doi-asserted-by":"publisher","first-page":"4037","DOI":"10.1172\/JCI60659","volume":"122","author":"J Helft","year":"2012","unstructured":"Helft, J. et al. Cross-presenting CD103+ dendritic cells are protected from influenza virus infection. J. Clin. Invest. 122, 4037\u20134047 (2012).","journal-title":"J. Clin. Invest."},{"key":"2134_CR12","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1126\/science.1108003","volume":"307","author":"L Delamarre","year":"2005","unstructured":"Delamarre, L., Pack, M., Chang, H., Mellman, I. & Trombetta, E. S. Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science 307, 1630\u20131634 (2005).","journal-title":"Science"},{"key":"2134_CR13","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.immuni.2018.09.024","volume":"49","author":"CS Garris","year":"2018","unstructured":"Garris, C. S. et al. Successful anti-PD-1 cancer immunotherapy requires T cell-dendritic cell crosstalk involving the cytokines IFN-\u03b3 and IL-12. Immunity 49, 1148\u20131161 (2018).","journal-title":"Immunity"},{"key":"2134_CR14","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/0092-8674(95)90520-0","volume":"80","author":"TN Stitt","year":"1995","unstructured":"Stitt, T. N. et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3\/Axl family of receptor tyrosine kinases. Cell 80, 661\u2013670 (1995).","journal-title":"Cell"},{"key":"2134_CR15","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev-immunol-032414-112103","volume":"33","author":"CV Rothlin","year":"2015","unstructured":"Rothlin, C. V., Carrera-Silva, E. A., Bosurgi, L. & Ghosh, S. TAM receptor signaling in immune homeostasis. Annu. Rev. Immunol. 33, 355\u2013391 (2015).","journal-title":"Annu. Rev. Immunol."},{"key":"2134_CR16","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1158\/1078-0432.CCR-16-2586","volume":"23","author":"HD Skinner","year":"2017","unstructured":"Skinner, H. D. et al. Integrative analysis identifies a novel AXL-PI3 kinase-PD-L1 signaling axis associated with radiation resistance in head and neck cancer. Clin. Cancer Res. 23, 2713\u20132722 (2017).","journal-title":"Clin. Cancer Res."},{"key":"2134_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0953-y","volume":"18","author":"Y Tsukita","year":"2019","unstructured":"Tsukita, Y. et al. Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas. Mol. Cancer 18, 24 (2019).","journal-title":"Mol. Cancer"},{"key":"2134_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cell.2016.02.065","volume":"165","author":"W Hugo","year":"2016","unstructured":"Hugo, W. et al. Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma. Cell 165, 35\u201344 (2016).","journal-title":"Cell"},{"key":"2134_CR19","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1126\/science.1232227","volume":"339","author":"LM Coussens","year":"2013","unstructured":"Coussens, L. M., Zitvogel, L. & Palucka, A. K. Neutralizing tumor-promoting chronic inflammation: a magic bullet? Science 339, 286\u2013291 (2013).","journal-title":"Science"},{"key":"2134_CR20","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1084\/jem.20150295","volume":"212","author":"A Mantovani","year":"2015","unstructured":"Mantovani, A. & Allavena, P. The interaction of anticancer therapies with tumor-associated macrophages. J. Exp. Med. 212, 435\u2013445 (2015).","journal-title":"J. Exp. Med."},{"key":"2134_CR21","doi-asserted-by":"publisher","first-page":"5069","DOI":"10.4049\/jimmunol.1101880","volume":"187","author":"SP Zahner","year":"2011","unstructured":"Zahner, S. P. et al. Conditional deletion of TGF-\u03b2R1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity. J. Immunol. 187, 5069\u20135076 (2011).","journal-title":"J. Immunol."},{"key":"2134_CR22","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1158\/2159-8290.CD-11-0073","volume":"1","author":"W Xue","year":"2011","unstructured":"Xue, W. et al. Response and resistance to NF-\u03baB inhibitors in mouse models of lung adenocarcinoma. Cancer Discov. 1, 236\u2013247 (2011).","journal-title":"Cancer Discov."},{"key":"2134_CR23","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/nmeth.4380","volume":"14","author":"M Stoeckius","year":"2017","unstructured":"Stoeckius, M. et al. Simultaneous epitope and transcriptome measurement in single cells. Nat. Methods 14, 865\u2013868 (2017).","journal-title":"Nat. Methods"},{"key":"2134_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1603-1","volume":"19","author":"M Stoeckius","year":"2018","unstructured":"Stoeckius, M. et al. Cell Hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics. Genome Biol. 19, 224 (2018).","journal-title":"Genome Biol."},{"key":"2134_CR25","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1126\/science.1247651","volume":"343","author":"DA Jaitin","year":"2014","unstructured":"Jaitin, D. A. et al. Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types. Science 343, 776\u2013779 (2014).","journal-title":"Science"},{"key":"2134_CR26","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.cell.2015.11.013","volume":"163","author":"F Paul","year":"2015","unstructured":"Paul, F. et al. Transcriptional heterogeneity and lineage commitment in myeloid progenitors. Cell 163, 1663\u20131677 (2015).","journal-title":"Cell"},{"key":"2134_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1812-2","volume":"20","author":"Y Baran","year":"2019","unstructured":"Baran, Y. et al. MetaCell: analysis of single cell RNA-seq data using K-nn graph partitions. Genome Biol. 20, 206 (2019).","journal-title":"Genome Biol."},{"key":"2134_CR28","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1016\/j.cell.2018.11.003","volume":"175","author":"MM Gubin","year":"2018","unstructured":"Gubin, M. M. et al. High-dimensional analysis delineates myeloid and lymphoid compartment remodeling during successful immune-checkpoint cancer therapy. Cell 175, 1443 (2018).","journal-title":"Cell"},{"key":"2134_CR29","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1038\/s41591-018-0096-5","volume":"24","author":"D Lambrechts","year":"2018","unstructured":"Lambrechts, D. et al. Phenotype molding of stromal cells in the lung tumor microenvironment. Nat. Med. 24, 1277\u20131289 (2018).","journal-title":"Nat. Med."},{"key":"2134_CR30","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1158\/0008-5472.CAN-09-2997","volume":"70","author":"SJ Holland","year":"2010","unstructured":"Holland, S. J. et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 70, 1544\u20131554 (2010).","journal-title":"Cancer Res."},{"key":"2134_CR31","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1038\/nbt.3386","volume":"33","author":"J Agudo","year":"2015","unstructured":"Agudo, J. et al. GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions. Nat. Biotechnol. 33, 1287\u20131292 (2015).","journal-title":"Nat. Biotechnol."}],"updated-by":[{"DOI":"10.1038\/s41586-020-2326-5","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41586-020-2134-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-020-2134-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-020-2134-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T18:04:01Z","timestamp":1684605841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-020-2134-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,25]]},"references-count":31,"journal-issue":{"issue":"7802","published-print":{"date-parts":[[2020,4,9]]}},"alternative-id":["2134"],"URL":"https:\/\/doi.org\/10.1038\/s41586-020-2134-y","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.737616914.793573779","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,25]]},"assertion":[{"value":"10 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2020","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41586-020-2326-5","URL":"https:\/\/doi.org\/10.1038\/s41586-020-2326-5","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Research support for these studies was provided by Regeneron and Takeda. The authors declare no other competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}