{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T02:06:27Z","timestamp":1794103587225,"version":"4.8.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7817","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2020,7,23]]},"DOI":"10.1038\/s41586-020-2369-7","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T16:02:29Z","timestamp":1591200149000},"page":"615-619","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":200,"title":["IGF1R is an entry receptor for respiratory syncytial virus"],"prefix":"10.1038","volume":"583","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1280-3615","authenticated-orcid":false,"given":"Cameron D.","family":"Griffiths","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne M.","family":"Bilawchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyla C.","family":"Jamieson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Elawar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Cen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haeun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Ogg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel Dylan","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-6845","authenticated-orcid":false,"given":"Bernard","family":"Thienpont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-4516","authenticated-orcid":false,"given":"Anil","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom C.","family":"Hobman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9629-6595","authenticated-orcid":false,"given":"David","family":"Proud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo J.","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Marchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"2369_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1128\/CMR.00010-16","volume":"30","author":"C Griffiths","year":"2017","unstructured":"Griffiths, C., Drews, S. J. & Marchant, D. J. Respiratory syncytial virus: infection, detection, and new options for prevention and treatment. Clin. Microbiol. Rev. 30, 277\u2013319 (2017).","journal-title":"Clin. Microbiol. Rev."},{"key":"2369_CR2","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1038\/nm.2444","volume":"17","author":"F Tayyari","year":"2011","unstructured":"Tayyari, F. et al. Identification of nucleolin as a cellular receptor for human respiratory syncytial virus. Nat. Med. 17, 1132\u20131135 (2011).","journal-title":"Nat. Med."},{"key":"2369_CR3","doi-asserted-by":"publisher","first-page":"e14193","DOI":"10.1371\/journal.pone.0014193","volume":"5","author":"M Barel","year":"2010","unstructured":"Barel, M., Meibom, K. & Charbit, A. Nucleolin, a shuttle protein promoting infection of human monocytes by Francisella tularensis. PLoS ONE 5, e14193 (2010).","journal-title":"PLoS ONE"},{"key":"2369_CR4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/s41579-019-0149-x","volume":"17","author":"MB Battles","year":"2019","unstructured":"Battles, M. B. & McLellan, J. S. Respiratory syncytial virus entry and how to block it. Nat. Rev. Microbiol. 17, 233\u2013245 (2019).","journal-title":"Nat. Rev. Microbiol."},{"key":"2369_CR5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3390\/v9080207","volume":"9","author":"LM Bilawchuk","year":"2017","unstructured":"Bilawchuk, L. M., Griffiths, C. D., Jensen, L. D., Elawar, F. & Marchant, D. J. The susceptibilities of respiratory syncytial virus to nucleolin receptor blocking and antibody neutralization are dependent upon the method of virus purification. Viruses 9, 207 (2017).","journal-title":"Viruses"},{"key":"2369_CR6","doi-asserted-by":"publisher","first-page":"11359","DOI":"10.1128\/JVI.00804-10","volume":"84","author":"D Marchant","year":"2010","unstructured":"Marchant, D. et al. Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism. J. Virol. 84, 11359\u201311373 (2010).","journal-title":"J. Virol."},{"key":"2369_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12001-6","volume":"7","author":"F Elawar","year":"2017","unstructured":"Elawar, F. et al. A virological and phylogenetic analysis of the emergence of new clades of respiratory syncytial virus. Sci. Rep. 7, 12232 (2017).","journal-title":"Sci. Rep."},{"key":"2369_CR8","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1126\/science.1234914","volume":"340","author":"JS McLellan","year":"2013","unstructured":"McLellan, J. S. et al. Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science 340, 1113\u20131117 (2013).","journal-title":"Science"},{"key":"2369_CR9","doi-asserted-by":"publisher","first-page":"e1003309","DOI":"10.1371\/journal.ppat.1003309","volume":"9","author":"MA Krzyzaniak","year":"2013","unstructured":"Krzyzaniak, M. A., Zumstein, M. T., Gerez, J. A., Picotti, P. & Helenius, A. Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein. PLoS Pathog. 9, e1003309 (2013).","journal-title":"PLoS Pathog."},{"key":"2369_CR10","doi-asserted-by":"publisher","first-page":"e1005622","DOI":"10.1371\/journal.ppat.1005622","volume":"12","author":"MG Currier","year":"2016","unstructured":"Currier, M. G. et al. EGFR interacts with the fusion protein of respiratory syncytial virus strain 2-20 and mediates infection and mucin expression. PLoS Pathog. 12, e1005622 (2016).","journal-title":"PLoS Pathog."},{"key":"2369_CR11","doi-asserted-by":"publisher","first-page":"53035","DOI":"10.1074\/jbc.M308093200","volume":"278","author":"MM Monick","year":"2003","unstructured":"Monick, M. M. et al. Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J. Biol. Chem. 278, 53035\u201353044 (2003).","journal-title":"J. Biol. Chem."},{"key":"2369_CR12","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1126\/science.1243283","volume":"342","author":"JS McLellan","year":"2013","unstructured":"McLellan, J. S. et al. Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science 342, 592\u2013598 (2013).","journal-title":"Science"},{"key":"2369_CR13","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/nature03571","volume":"436","author":"L Pelkmans","year":"2005","unstructured":"Pelkmans, L. et al. Genome-wide analysis of human kinases in clathrin- and caveolae\/raft-mediated endocytosis. Nature 436, 78\u201386 (2005).","journal-title":"Nature"},{"key":"2369_CR14","doi-asserted-by":"publisher","first-page":"2681","DOI":"10.4049\/jimmunol.166.4.2681","volume":"166","author":"M Monick","year":"2001","unstructured":"Monick, M., Staber, J., Thomas, K. & Hunninghake, G. Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase. J. Immunol. 166, 2681\u20132687 (2001).","journal-title":"J. Immunol."},{"key":"2369_CR15","doi-asserted-by":"publisher","first-page":"9280","DOI":"10.1073\/pnas.0832269100","volume":"100","author":"M Lakadamyali","year":"2003","unstructured":"Lakadamyali, M., Rust, M. J., Babcock, H. P. & Zhuang, X. Visualizing infection of individual influenza viruses. Proc. Natl Acad. Sci. USA 100, 9280\u20139285 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2369_CR16","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1128\/JVI.79.2.1113-1124.2005","volume":"79","author":"L Zhang","year":"2004","unstructured":"Zhang, L. et al. Infection of ciliated cells by human parainfluenza virus type 3 in an in vitro model of human airway epithelium. J. Virol. 79, 1113\u20131124 (2004).","journal-title":"J. Virol."},{"key":"2369_CR17","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.micpath.2006.11.003","volume":"42","author":"TM Krunkosky","year":"2007","unstructured":"Krunkosky, T. M., Jordan, J. L., Chambers, E. & Krause, D. C. Mycoplasma pneumoniae host\u2013pathogen studies in an air\u2013liquid culture of differentiated human airway epithelial cells. Microb. Pathog. 42, 98\u2013103 (2007).","journal-title":"Microb. Pathog."},{"key":"2369_CR18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3390\/vaccines5030027","volume":"5","author":"P Mastrangelo","year":"2017","unstructured":"Mastrangelo, P. et al. Targeting host cell surface nucleolin for RSV therapy: challenges and opportunities. Vaccines (Basel) 5, 27 (2017).","journal-title":"Vaccines (Basel)"},{"key":"2369_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-017-0017-y","volume":"1","author":"RC Ekyalongo","year":"2017","unstructured":"Ekyalongo, R. C. & Yee, D. Revisiting the IGF-1R as a breast cancer target. NPJ Precis. Oncol. 1, 14 (2017).","journal-title":"NPJ Precis. Oncol."},{"key":"2369_CR20","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/312763a0","volume":"312","author":"AG Dalgleish","year":"1984","unstructured":"Dalgleish, A. G. et al. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312, 763\u2013767 (1984).","journal-title":"Nature"},{"key":"2369_CR21","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1126\/science.272.5263.872","volume":"272","author":"Y Feng","year":"1996","unstructured":"Feng, Y., Broder, C. C., Kennedy, P. E. & Berger, E. A. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272, 872\u2013877 (1996).","journal-title":"Science"},{"key":"2369_CR22","doi-asserted-by":"publisher","first-page":"8146","DOI":"10.1128\/JVI.78.15.8146-8158.2004","volume":"78","author":"S Bose","year":"2004","unstructured":"Bose, S., Basu, M. & Banerjee, A. K. Role of nucleolin in human parainfluenza virus type 3 infection of human lung epithelial cells. J. Virol. 78, 8146\u20138158 (2004).","journal-title":"J. Virol."},{"key":"2369_CR23","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1126\/science.1158298","volume":"321","author":"H von Bernuth","year":"2008","unstructured":"von Bernuth, H. et al. Pyogenic bacterial infections in humans with MyD88 deficiency. Science 321, 691\u2013696 (2008).","journal-title":"Science"},{"key":"2369_CR24","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1126\/science.1139522","volume":"317","author":"SY Zhang","year":"2007","unstructured":"Zhang, S. Y. et al. TLR3 deficiency in patients with herpes simplex encephalitis. Science 317, 1522\u20131527 (2007).","journal-title":"Science"},{"key":"2369_CR25","doi-asserted-by":"publisher","first-page":"6449","DOI":"10.1074\/jbc.RA118.002406","volume":"293","author":"A Bareja","year":"2018","unstructured":"Bareja, A., Hodgkinson, C. P., Soderblom, E., Waitt, G. & Dzau, V. J. The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)\u2013IGF1 receptor pathway. J. Biol. Chem. 293, 6449\u20136459 (2018).","journal-title":"J. Biol. Chem."},{"key":"2369_CR26","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1164\/ajrccm\/140.2.449","volume":"140","author":"L Churchill","year":"1989","unstructured":"Churchill, L. et al. Cyclooxygenase metabolism of endogenous arachidonic acid by cultured human tracheal epithelial cells. Am. Rev. Respir. Dis. 140, 449\u2013459 (1989).","journal-title":"Am. Rev. Respir. Dis."},{"key":"2369_CR27","doi-asserted-by":"publisher","first-page":"10710","DOI":"10.1128\/JVI.00986-09","volume":"83","author":"S Kwilas","year":"2009","unstructured":"Kwilas, S. et al. Respiratory syncytial virus grown in Vero cells contains a truncated attachment protein that alters its infectivity and dependence on glycosaminoglycans. J. Virol. 83, 10710\u201310718 (2009).","journal-title":"J. Virol."},{"key":"2369_CR28","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1038\/s41591-018-0096-5","volume":"24","author":"D Lambrechts","year":"2018","unstructured":"Lambrechts, D. et al. Phenotype molding of stromal cells in the lung tumor microenvironment. Nat. Med. 24, 1277\u20131289 (2018).","journal-title":"Nat. Med."},{"key":"2369_CR29","doi-asserted-by":"publisher","first-page":"4063","DOI":"10.1128\/jvi.65.8.4063-4069.1991","volume":"65","author":"N Srinivasakumar","year":"1991","unstructured":"Srinivasakumar, N., Ogra, P. L. & Flanagan, T. D. Characteristics of fusion of respiratory syncytial virus with HEp-2 cells as measured by R18 fluorescence dequenching assay. J. Virol. 65, 4063\u20134069 (1991).","journal-title":"J. Virol."}],"updated-by":[{"DOI":"10.1038\/s41586-020-2437-z","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-020-2369-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-020-2369-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-020-2369-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T17:26:52Z","timestamp":1684862812000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-020-2369-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,3]]},"references-count":29,"journal-issue":{"issue":"7817","published-print":{"date-parts":[[2020,7,23]]}},"alternative-id":["2369"],"URL":"https:\/\/doi.org\/10.1038\/s41586-020-2369-7","relation":{"correction":[{"id-type":"doi","id":"10.1038\/s41586-020-2437-z","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,3]]},"assertion":[{"value":"14 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2020","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41586-020-2437-z","URL":"https:\/\/doi.org\/10.1038\/s41586-020-2437-z","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}