{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:55:12Z","timestamp":1793393712760,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7834","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2020,11,19]]},"DOI":"10.1038\/s41586-020-2890-8","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T16:37:40Z","timestamp":1604507860000},"page":"460-465","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia"],"prefix":"10.1038","volume":"587","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8168-1538","authenticated-orcid":false,"given":"Lucia M.","family":"Moreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Takawale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0595-6661","authenticated-orcid":false,"given":"Mohit","family":"Hulsurkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Menassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9019-2215","authenticated-orcid":false,"given":"Agne","family":"Antanaviciute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9502-1530","authenticated-orcid":false,"given":"Satadru K.","family":"Lahiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5458-6065","authenticated-orcid":false,"given":"Neil","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Psarros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3354-3314","authenticated-orcid":false,"given":"Alexander J.","family":"Sparrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Antoine","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Ashley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Naud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Barallobre-Barreiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6799-0553","authenticated-orcid":false,"given":"Konstantinos","family":"Theofilatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele V.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia K.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-1617","authenticated-orcid":false,"given":"Barbara","family":"Casadei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoumo","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Zajac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Davey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sirois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8522-1002","authenticated-orcid":false,"given":"Adam","family":"Mead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-829X","authenticated-orcid":false,"given":"Manuel","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2887-1874","authenticated-orcid":false,"given":"Rana","family":"Sayeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Krasopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Redwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M.","family":"Channon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Tardif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5044-672X","authenticated-orcid":false,"given":"Xander H. T.","family":"Wehrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5565-3311","authenticated-orcid":false,"given":"Stanley","family":"Nattel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-1239","authenticated-orcid":false,"given":"Svetlana","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"2890_CR1","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","volume":"129","author":"SS Chugh","year":"2014","unstructured":"Chugh, S. S. et al. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation 129, 837\u2013847 (2014).","journal-title":"Circulation"},{"key":"2890_CR2","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1161\/CIRCRESAHA.117.311081","volume":"122","author":"J Heijman","year":"2018","unstructured":"Heijman, J., Guichard, J. B., Dobrev, D. & Nattel, S. Translational challenges in atrial fibrillation. Circ. Res. 122, 752\u2013773 (2018).","journal-title":"Circ. Res."},{"key":"2890_CR3","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1007\/s00198-008-0603-5","volume":"19","author":"MA Karsdal","year":"2008","unstructured":"Karsdal, M. A., Byrjalsen, I., Leeming, D. J., Delmas, P. D. & Christiansen, C. The effects of oral calcitonin on bone collagen maturation: implications for bone turnover and quality. Osteoporos. Int. 19, 1355\u20131361 (2008).","journal-title":"Osteoporos. Int."},{"key":"2890_CR4","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.celrep.2015.08.083","volume":"13","author":"M Yamaguchi","year":"2015","unstructured":"Yamaguchi, M. et al. Calcitonin receptor signaling inhibits muscle stem cells from escaping the quiescent state and the niche. Cell Rep. 13, 302\u2013314 (2015).","journal-title":"Cell Rep."},{"key":"2890_CR5","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1373\/clinchem.2003.026963","volume":"50","author":"JP Basuyau","year":"2004","unstructured":"Basuyau, J. P., Mallet, E., Leroy, M. & Brunelle, P. Reference intervals for serum calcitonin in men, women, and children. Clin. Chem. 50, 1828\u20131830 (2004).","journal-title":"Clin. Chem."},{"key":"2890_CR6","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature14177","volume":"518","author":"AE Locke","year":"2015","unstructured":"Locke, A. E. et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197\u2013206 (2015).","journal-title":"Nature"},{"key":"2890_CR7","first-page":"555","volume":"1975","author":"B Cuparencu","year":"1975","unstructured":"Cuparencu, B., Ticsa, I., Barzu, T., Sandor, V. & Gozariu, L. [Effect of calcitonin on certain experimental models of arrhythmia]. Therapie 1975, 555\u2013563 (1975).","journal-title":"Therapie"},{"key":"2890_CR8","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1536\/ihj.18.214","volume":"18","author":"S Chiba","year":"1977","unstructured":"Chiba, S. & Himori, N. Effects of salmon calcitonin on SA nodal pacemaker activity and contractility in isolated, blood-perfused atrial and papillary muscle preparations of dogs. Jpn. Heart J. 18, 214\u2013220 (1977).","journal-title":"Jpn. Heart J."},{"key":"2890_CR9","doi-asserted-by":"publisher","first-page":"R31","DOI":"10.1530\/EC-14-0012","volume":"3","author":"T Ogawa","year":"2014","unstructured":"Ogawa, T. & de Bold, A. J. The heart as an endocrine organ. Endocr. Connect. 3, R31\u2013R44 (2014).","journal-title":"Endocr. Connect."},{"key":"2890_CR10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.matbio.2015.02.006","volume":"44-46","author":"S Vadon-Le Goff","year":"2015","unstructured":"Vadon-Le Goff, S., Hulmes, D. J. & Moali, C. BMP-1\/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling. Matrix Biol. 44\u201346, 14\u201323 (2015).","journal-title":"Matrix Biol."},{"key":"2890_CR11","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1161\/CIRCULATIONAHA.113.004742","volume":"129","author":"RP Martins","year":"2014","unstructured":"Martins, R. P. et al. Dominant frequency increase rate predicts transition from paroxysmal to long-term persistent atrial fibrillation. Circulation 129, 1472\u20131482 (2014).","journal-title":"Circulation"},{"key":"2890_CR12","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1161\/CIRCRESAHA.110.228809","volume":"108","author":"T Grieskamp","year":"2011","unstructured":"Grieskamp, T., Rudat, C., L\u00fcdtke, T. H., Norden, J. & Kispert, A. Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. Circ. Res. 108, 813\u2013823 (2011).","journal-title":"Circ. Res."},{"key":"2890_CR13","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/labinvest.2010.181","volume":"91","author":"JE Bond","year":"2011","unstructured":"Bond, J. E. et al. Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling. Lab. Invest. 91, 499\u2013508 (2011).","journal-title":"Lab. Invest."},{"key":"2890_CR14","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/ng.3818","volume":"49","author":"H Li","year":"2017","unstructured":"Li, H. et al. Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors. Nat. Genet. 49, 708\u2013718 (2017).","journal-title":"Nat. Genet."},{"key":"2890_CR15","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1359\/jbmr.080310","volume":"23","author":"RA Davey","year":"2008","unstructured":"Davey, R. A. et al. Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice. J. Bone Miner. Res. 23, 1182\u20131193 (2008).","journal-title":"J. Bone Miner. Res."},{"key":"2890_CR16","doi-asserted-by":"publisher","first-page":"e001733","DOI":"10.1161\/JAHA.114.001733","volume":"4","author":"C Ozcan","year":"2015","unstructured":"Ozcan, C., Battaglia, E., Young, R. & Suzuki, G. LKB1 knockout mouse develops spontaneous atrial fibrillation and provides mechanistic insights into human disease process. J. Am. Heart Assoc. 4, e001733 (2015).","journal-title":"J. Am. Heart Assoc."},{"key":"2890_CR17","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1161\/CIRCRESAHA.118.313811","volume":"124","author":"L Ni","year":"2019","unstructured":"Ni, L. et al. Atrial-specific gene delivery using an adeno-associated viral vector. Circ. Res. 124, 256\u2013262 (2019).","journal-title":"Circ. Res."},{"key":"2890_CR18","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jacep.2017.03.002","volume":"3","author":"S Nattel","year":"2017","unstructured":"Nattel, S. Molecular and cellular mechanisms of atrial\u00a0fibrosis in atrial\u00a0fibrillation. JACC Clin. Electrophysiol. 3, 425\u2013435 (2017).","journal-title":"JACC Clin. Electrophysiol."},{"key":"2890_CR19","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3109\/00016348709103646","volume":"66","author":"S Balabanova","year":"1987","unstructured":"Balabanova, S., Kruse, B. & Wolf, A. S. Calcitonin secretion by human placental tissue. Acta Obstet. Gynecol. Scand. 66, 323\u2013326 (1987).","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"2890_CR20","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/j.1749-6632.1984.tb38297.x","volume":"438","author":"F Fraioli","year":"1984","unstructured":"Fraioli, F. et al. Beta-endorphin, Met-enkephalin, and calcitonin in human semen: evidence for a possible role in human sperm motility. Ann. NY Acad. Sci. 438, 365\u2013370 (1984).","journal-title":"Ann. NY Acad. Sci."},{"key":"2890_CR21","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.ijcard.2016.08.204","volume":"223","author":"P Schuetz","year":"2016","unstructured":"Schuetz, P., Daniels, L. B., Kulkarni, P., Anker, S. D. & Mueller, B. Procalcitonin: A new biomarker for the cardiologist. Int. J. Cardiol. 223, 390\u2013397 (2016).","journal-title":"Int. J. Cardiol."},{"key":"2890_CR22","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1161\/CIRCULATIONAHA.107.748053","volume":"117","author":"B Burstein","year":"2008","unstructured":"Burstein, B., Libby, E., Calderone, A. & Nattel, S. Differential behaviors of atrial versus ventricular fibroblasts: a potential role for platelet-derived growth factor in atrial-ventricular remodeling differences. Circulation 117, 1630\u20131641 (2008).","journal-title":"Circulation"},{"key":"2890_CR23","doi-asserted-by":"publisher","first-page":"e92042","DOI":"10.1371\/journal.pone.0092042","volume":"9","author":"KV Andreassen","year":"2014","unstructured":"Andreassen, K. V. et al. Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. PLoS One 9, e92042 (2014).","journal-title":"PLoS One"},{"key":"2890_CR24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/bph.14075","volume":"175","author":"DL Hay","year":"2018","unstructured":"Hay, D. L., Garelja, M. L., Poyner, D. R. & Walker, C. S. Update on the pharmacology of calcitonin\/CGRP family of peptides: IUPHAR Review 25. Br. J. Pharmacol. 175, 3\u201317 (2018).","journal-title":"Br. J. Pharmacol."},{"key":"2890_CR25","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/S0945-053X(98)90013-0","volume":"16","author":"DJ Prockop","year":"1998","unstructured":"Prockop, D. J., Sieron, A. L. & Li, S. W. Procollagen N-proteinase and procollagen C-proteinase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling. Matrix Biol. 16, 399\u2013408 (1998).","journal-title":"Matrix Biol."},{"key":"2890_CR26","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1055\/s-0032-1304251","volume":"44","author":"S Zhang","year":"2012","unstructured":"Zhang, S., Kaplan, F. S. & Shore, E. M. Different roles of GNAS and cAMP signaling during early and late stages of osteogenic differentiation. Horm. Metab. Res. 44, 724\u2013731 (2012).","journal-title":"Horm. Metab. Res."},{"key":"2890_CR27","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3390\/cells9010069","volume":"9","author":"M Delaunay","year":"2019","unstructured":"Delaunay, M., Osman, H., Kaiser, S. & Diviani, D. The role of cyclic AMP signaling in cardiac fibrosis. Cells 9, 69 (2019).","journal-title":"Cells"},{"key":"2890_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5656","volume":"5","author":"F Nakamura","year":"2014","unstructured":"Nakamura, F., Song, M., Hartwig, J. H. & Stossel, T. P. Documentation and localization of force-mediated filamin A domain perturbations in moving cells. Nat. Commun. 5, 4656 (2014).","journal-title":"Nat. Commun."},{"key":"2890_CR29","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1124\/mol.104.008615","volume":"67","author":"DL Hay","year":"2005","unstructured":"Hay, D. L., Christopoulos, G., Christopoulos, A., Poyner, D. R. & Sexton, P. M. Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes. Mol. Pharmacol. 67, 1655\u20131665 (2005).","journal-title":"Mol. Pharmacol."},{"key":"2890_CR30","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1093\/cvr\/cvy173","volume":"115","author":"S Surinkaew","year":"2019","unstructured":"Surinkaew, S. et al. Exchange protein activated by cyclic-adenosine monophosphate (Epac) regulates atrial fibroblast function and controls cardiac remodelling. Cardiovasc. Res. 115, 94\u2013106 (2019).","journal-title":"Cardiovasc. Res."},{"key":"2890_CR31","doi-asserted-by":"publisher","first-page":"340ra74","DOI":"10.1126\/scitranslmed.aac4296","volume":"8","author":"SN Reilly","year":"2016","unstructured":"Reilly, S. N. et al. Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase. Sci. Transl. Med. 8, 340ra74 (2016).","journal-title":"Sci. Transl. Med."},{"key":"2890_CR32","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature24676","volume":"552","author":"S Schafer","year":"2017","unstructured":"Schafer, S. et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature 552, 110\u2013115 (2017).","journal-title":"Nature"},{"key":"2890_CR33","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1073\/pnas.95.1.346","volume":"95","author":"M Hohenegger","year":"1998","unstructured":"Hohenegger, M. et al. Gsalpha-selective G protein antagonists. Proc. Natl Acad. Sci. USA 95, 346\u2013351 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2890_CR34","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1161\/CIRCULATIONAHA.119.039642","volume":"140","author":"KM Alsina","year":"2019","unstructured":"Alsina, K. M. et al. Loss of protein phosphatase 1 regulatory subunit PPP1R3A promotes atrial fibrillation. Circulation 140, 681\u2013693 (2019).","journal-title":"Circulation"},{"key":"2890_CR35","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1093\/cvr\/cvw075","volume":"110","author":"J Barallobre-Barreiro","year":"2016","unstructured":"Barallobre-Barreiro, J. et al. Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110, 419\u2013430 (2016).","journal-title":"Cardiovasc. Res."},{"key":"2890_CR36","doi-asserted-by":"crossref","unstructured":"Picelli, S. et al.\u00a0Full-length RNA-seq from single cells using Smart-seq2. Nat. Protoc. 9, 171\u2013181\u00a0(2014).","DOI":"10.1038\/nprot.2014.006"},{"key":"2890_CR37","unstructured":"Andrews, S. FastQC: a quality control tool for high throughput sequence data. http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\u00a0\u00a0(2010)."},{"key":"2890_CR38","doi-asserted-by":"crossref","unstructured":"Kuhn, R. M., Haussler, D. & Kent, W. J. The UCSC genome browser and associated tools. Brief. Bioinform.\u00a014,\u00a0144\u2013161 (2013).","DOI":"10.1093\/bib\/bbs038"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41586-020-2890-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-020-2890-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-020-2890-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T22:07:39Z","timestamp":1684620459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-020-2890-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,4]]},"references-count":38,"journal-issue":{"issue":"7834","published-print":{"date-parts":[[2020,11,19]]}},"alternative-id":["2890"],"URL":"https:\/\/doi.org\/10.1038\/s41586-020-2890-8","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,4]]},"assertion":[{"value":"18 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}