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J.K., S.D.M. and A.L. hold patents and patent applications related to the findings described herein. D.M.H. is an inventor on a patent for anti-A\u03b2 antibodies licensed to Eli Lilly by Washington University. D.M.H. and H.J. are inventors on a patent for anti-apoE antibodies licensed to NextCure. D.M.H. and H.J. are listed as inventors on a patent licensed by Washington University to C2N Diagnostics on the therapeutic use of anti-tau antibodies. D.M.H. co-founded and is on the scientific advisory board of C2N Diagnostics. C2N Diagnostics has licensed certain anti-tau antibodies to AbbVie for therapeutic development. D.M.H. is on the scientific advisory board of Denali and consults for Genentech, Merck, and Cajal Neuroscience. C.C. receives research support from Biogen, EISAI, Alector and Parabon. The funders of the study had no role in the collection, analysis, or interpretation of data, in the writing of the manuscript, or in the decision to submit the paper for publication. C.C. is a member of the advisory board of Vivid Genetics, Halia Therapeutics and ADx Healthcare. J.P.C. has served on a medical advisory board for Otsuka Pharmaceuticals. The authors declare no other competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}