{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:49:35Z","timestamp":1793886575173,"version":"4.8.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7861","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2021,6,3]]},"DOI":"10.1038\/s41586-021-03547-7","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T12:03:49Z","timestamp":1620821029000},"page":"100-105","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":938,"title":["An aged immune system drives senescence and ageing of solid organs"],"prefix":"10.1038","volume":"594","author":[{"given":"Matthew J.","family":"Yousefzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael R.","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe C.","family":"Schmiechen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy E.","family":"Trussoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luise","family":"Angelini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoo-A","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara J.","family":"McGowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L.","family":"Burrack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokio","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan D.","family":"O\u2019Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin A.","family":"McGuckian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan I.","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Bank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin A.","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smitha P. S.","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Klug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren C.","family":"Ladiges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin E.","family":"Burd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas F.","family":"LaRusso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam V.","family":"Vo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinsheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric E.","family":"Kelley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Huard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8120-4547","authenticated-orcid":false,"given":"Ingunn M.","family":"Stromnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1068-7099","authenticated-orcid":false,"given":"Paul D.","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1074-1385","authenticated-orcid":false,"given":"Laura J.","family":"Niedernhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"3547_CR1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","volume":"159","author":"BK Kennedy","year":"2014","unstructured":"Kennedy, B. K. et al. Geroscience: linking aging to chronic disease. Cell 159, 709\u2013713 (2014).","journal-title":"Cell"},{"key":"3547_CR2","doi-asserted-by":"publisher","first-page":"e006413","DOI":"10.1136\/bmjopen-2014-006413","volume":"5","author":"JL St Sauver","year":"2015","unstructured":"St Sauver, J. L. et al. Risk of developing multimorbidity across all ages in an historical cohort study: differences by sex and ethnicity. BMJ Open 5, e006413 (2015).","journal-title":"BMJ Open"},{"key":"3547_CR3","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.redox.2018.04.007","volume":"17","author":"AR Robinson","year":"2018","unstructured":"Robinson, A. R. et al. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol. 17, 259\u2013273 (2018).","journal-title":"Redox Biol."},{"key":"3547_CR4","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/j.1474-9726.2012.00828.x","volume":"11","author":"J Wang","year":"2012","unstructured":"Wang, J., Clauson, C. L., Robbins, P. D., Niedernhofer, L. J. & Wang, Y. The oxidative DNA lesions 8,5\u2032-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell 11, 714\u2013716 (2012).","journal-title":"Aging Cell"},{"key":"3547_CR5","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/nature16932","volume":"530","author":"DJ Baker","year":"2016","unstructured":"Baker, D. J. et al. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature 530, 184\u2013189 (2016).","journal-title":"Nature"},{"key":"3547_CR6","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/acel.12344","volume":"14","author":"Y Zhu","year":"2015","unstructured":"Zhu, Y. et al. The Achilles\u2019 heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14, 644\u2013658 (2015).","journal-title":"Aging Cell"},{"key":"3547_CR7","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","volume":"24","author":"M Xu","year":"2018","unstructured":"Xu, M. et al. Senolytics improve physical function and increase lifespan in old age. Nat. Med. 24, 1246\u20131256 (2018).","journal-title":"Nat. Med."},{"key":"3547_CR8","doi-asserted-by":"crossref","unstructured":"Pettan-Brewer, C. & Treuting, P. M. Practical pathology of aging mice. Pathobiol. Aging Age Relat. Dis. 1, (2011).","DOI":"10.3402\/pba.v1i0.7202"},{"key":"3547_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.exger.2018.01.010","volume":"104","author":"SA Bumgardner","year":"2018","unstructured":"Bumgardner, S. A. et al. Genetic influence on splenic natural killer cell frequencies and maturation among aged mice. Exp. Gerontol. 104, 9\u201316 (2018).","journal-title":"Exp. Gerontol."},{"key":"3547_CR10","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1474-9726.2009.00489.x","volume":"8","author":"Y Liu","year":"2009","unstructured":"Liu, Y. et al. Expression of p16INK4a in peripheral blood T-cells is a biomarker of human aging. Aging Cell 8, 439\u2013448 (2009).","journal-title":"Aging Cell"},{"key":"3547_CR11","doi-asserted-by":"publisher","first-page":"268ra179","DOI":"10.1126\/scitranslmed.3009892","volume":"6","author":"JB Mannick","year":"2014","unstructured":"Mannick, J. B. et al. mTOR inhibition improves immune function in the elderly. Sci. Transl. Med. 6, 268ra179 (2014).","journal-title":"Sci. Transl. Med."},{"key":"3547_CR12","doi-asserted-by":"publisher","first-page":"eaaq1564","DOI":"10.1126\/scitranslmed.aaq1564","volume":"10","author":"JB Mannick","year":"2018","unstructured":"Mannick, J. B. et al. TORC1 inhibition enhances immune function and reduces infections in the elderly. Sci. Transl. Med. 10, eaaq1564 (2018).","journal-title":"Sci. Transl. Med."},{"key":"3547_CR13","doi-asserted-by":"publisher","first-page":"a025940","DOI":"10.1101\/cshperspect.a025940","volume":"6","author":"SJ Olshansky","year":"2016","unstructured":"Olshansky, S. J. Articulating the case for the longevity dividend. Cold Spring Harb. Perspect. Med. 6, a025940 (2016).","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"3547_CR14","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nature13193","volume":"509","author":"JM van Deursen","year":"2014","unstructured":"van Deursen, J. M. The role of senescent cells in ageing. Nature 509, 439\u2013446 (2014).","journal-title":"Nature"},{"key":"3547_CR15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ebiom.2017.04.013","volume":"21","author":"JL Kirkland","year":"2017","unstructured":"Kirkland, J. L. & Tchkonia, T. Cellular senescence: a translational perspective. EBioMedicine 21, 21\u201328 (2017).","journal-title":"EBioMedicine"},{"key":"3547_CR16","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/ni.2588","volume":"14","author":"JJ Goronzy","year":"2013","unstructured":"Goronzy, J. J. & Weyand, C. M. Understanding immunosenescence to improve responses to vaccines. Nat. Immunol. 14, 428\u2013436 (2013).","journal-title":"Nat. Immunol."},{"key":"3547_CR17","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1172\/JCI22475","volume":"114","author":"J Krishnamurthy","year":"2004","unstructured":"Krishnamurthy, J. et al. Ink4a\/Arf expression is a biomarker of aging. J. Clin. Invest. 114, 1299\u20131307 (2004).","journal-title":"J. Clin. Invest."},{"key":"3547_CR18","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/acel.12455","volume":"15","author":"R Vicente","year":"2016","unstructured":"Vicente, R., Mausset-Bonnefont, A. L., Jorgensen, C., Louis-Plence, P. & Brondello, J. M. Cellular senescence impact on immune cell fate and function. Aging Cell 15, 400\u2013406 (2016).","journal-title":"Aging Cell"},{"key":"3547_CR19","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1002\/eji.201546178","volume":"46","author":"M Pinti","year":"2016","unstructured":"Pinti, M. et al. Aging of the immune system: Focus on inflammation and vaccination. Eur. J. Immunol. 46, 2286\u20132301 (2016).","journal-title":"Eur. J. Immunol."},{"key":"3547_CR20","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/stem.1261","volume":"31","author":"JS Cho","year":"2013","unstructured":"Cho, J. S., Kook, S. H., Robinson, A. R., Niedernhofer, L. J. & Lee, B. C. Cell autonomous and nonautonomous mechanisms drive hematopoietic stem\/progenitor cell loss in the absence of DNA repair. Stem Cells 31, 511\u2013525 (2013).","journal-title":"Stem Cells"},{"key":"3547_CR21","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/hep.24713","volume":"55","author":"SQ Gregg","year":"2012","unstructured":"Gregg, S. Q. et al. A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology 55, 609\u2013621 (2012).","journal-title":"Hepatology"},{"key":"3547_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1611","volume":"3","author":"M Lavasani","year":"2012","unstructured":"Lavasani, M. et al. Muscle-derived stem\/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat. Commun. 3, 608 (2012).","journal-title":"Nat. Commun."},{"key":"3547_CR23","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.mad.2012.11.002","volume":"134","author":"LA Nasto","year":"2013","unstructured":"Nasto, L. A. et al. Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs. Mech. Ageing Dev. 134, 35\u201342 (2013).","journal-title":"Mech. Ageing Dev."},{"key":"3547_CR24","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1038\/nature05456","volume":"444","author":"LJ Niedernhofer","year":"2006","unstructured":"Niedernhofer, L. J. et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 444, 1038\u20131043 (2006).","journal-title":"Nature"},{"key":"3547_CR25","doi-asserted-by":"publisher","first-page":"e0124661","DOI":"10.1371\/journal.pone.0124661","volume":"10","author":"S Siegemund","year":"2015","unstructured":"Siegemund, S., Shepherd, J., Xiao, C. & Sauer, K. hCD2-iCre and Vav-iCre mediated gene recombination patterns in murine hematopoietic cells. PLoS ONE 10, e0124661 (2015).","journal-title":"PLoS ONE"},{"key":"3547_CR26","doi-asserted-by":"publisher","first-page":"21846","DOI":"10.1074\/jbc.M111.337899","volume":"287","author":"Y Su","year":"2012","unstructured":"Su, Y., Orelli, B., Madireddy, A., Niedernhofer, L. J. & Sch\u00e4rer, O. D. Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair. J. Biol. Chem. 287, 21846\u201321855 (2012).","journal-title":"J. Biol. Chem."},{"key":"3547_CR27","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nri.2017.108","volume":"18","author":"AH Sharpe","year":"2017","unstructured":"Sharpe, A. H. & Pauken, K. E. The diverse functions of the PD1 inhibitory pathway. Nat. Rev. Immunol. 18, 153\u2013167 (2017).","journal-title":"Nat. Rev. Immunol."},{"key":"3547_CR28","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrc3960","volume":"15","author":"NE Sharpless","year":"2015","unstructured":"Sharpless, N. E. & Sherr, C. J. Forging a signature of in vivo senescence. Nat. Rev. Cancer 15, 397\u2013408 (2015).","journal-title":"Nat. Rev. Cancer"},{"key":"3547_CR29","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","volume":"5","author":"JP Copp\u00e9","year":"2010","unstructured":"Copp\u00e9, J. P., Desprez, P. Y., Krtolica, A. & Campisi, J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 5, 99\u2013118 (2010).","journal-title":"Annu. Rev. Pathol."},{"issue":"Pt B","key":"3547_CR30","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.freeradbiomed.2015.05.036","volume":"88","author":"H Zhang","year":"2015","unstructured":"Zhang, H., Davies, K. J. A. & Forman, H. J. Oxidative stress response and Nrf2 signaling in aging. Free Radic. Biol. Med. 88 (Pt B), 314\u2013336 (2015).","journal-title":"Free Radic. Biol. Med."},{"key":"3547_CR31","doi-asserted-by":"publisher","first-page":"15807","DOI":"10.1073\/pnas.0908805106","volume":"106","author":"K Shimatani","year":"2009","unstructured":"Shimatani, K., Nakashima, Y., Hattori, M., Hamazaki, Y. & Minato, N. PD-1+ memory phenotype CD4+ T cells expressing C\/EBP\u03b1 underlie T cell immunodepression in senescence and leukemia. Proc. Natl Acad. Sci. USA 106, 15807\u201315812 (2009).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"3547_CR32","first-page":"9.51.1","volume":"79","author":"J Zhao","year":"2017","unstructured":"Zhao, J. et al. Quantitative analysis of cellular senescence in culture and in vivo. Curr. Protoc. Cytom. 79, 9.51.1\u20139.51.25 (2017).","journal-title":"Curr. Protoc. Cytom."},{"key":"3547_CR33","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1681\/ASN.2010060641","volume":"22","author":"R Munshi","year":"2011","unstructured":"Munshi, R. et al. MCP-1 gene activation marks acute kidney injury. J. Am. Soc. Nephrol. 22, 165\u2013175 (2011).","journal-title":"J. Am. Soc. Nephrol."},{"key":"3547_CR34","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3389\/fmed.2017.00073","volume":"4","author":"CP Argyropoulos","year":"2017","unstructured":"Argyropoulos, C. P. et al. Rediscovering \u03b2-2 microglobulin as a biomarker across the spectrum of kidney diseases. Front. Med. (Lausanne) 4, 73 (2017).","journal-title":"Front. Med. (Lausanne)"},{"key":"3547_CR35","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.cell.2012.12.010","volume":"152","author":"CE Burd","year":"2013","unstructured":"Burd, C. E. et al. Monitoring tumorigenesis and senescence in vivo with a p16INK4a-luciferase model. Cell 152, 340\u2013351 (2013).","journal-title":"Cell"},{"key":"3547_CR36","doi-asserted-by":"publisher","first-page":"5082","DOI":"10.1128\/MCB.00293-08","volume":"28","author":"A Ahmad","year":"2008","unstructured":"Ahmad, A. et al. ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol. Cell. Biol. 28, 5082\u20135092 (2008).","journal-title":"Mol. Cell. Biol."},{"key":"3547_CR37","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/978-1-4939-8931-7_17","volume":"1896","author":"MJ Yousefzadeh","year":"2019","unstructured":"Yousefzadeh, M. J. et al. Mouse models of accelerated cellular senescence. Methods Mol. Biol. 1896, 203\u2013230 (2019).","journal-title":"Methods Mol. Biol."},{"key":"3547_CR38","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1002\/hep.26993","volume":"59","author":"JH Tabibian","year":"2014","unstructured":"Tabibian, J. H., O\u2019Hara, S. P., Splinter, P. L., Trussoni, C. E. & LaRusso, N. F. Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis. Hepatology 59, 2263\u20132275 (2014).","journal-title":"Hepatology"},{"key":"3547_CR39","doi-asserted-by":"crossref","unstructured":"Yousefzadeh, M. J. et al. Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans. Aging Cell 17, e12706 (2018).","DOI":"10.1111\/acel.12706"},{"key":"3547_CR40","doi-asserted-by":"publisher","first-page":"31478","DOI":"10.3402\/pba.v6.31478","volume":"6","author":"W Ladiges","year":"2016","unstructured":"Ladiges, W. Pathology assessment is necessary to validate translational endpoints in preclinical aging studies. Pathobiol. Aging Age Relat. Dis. 6, 31478 (2016).","journal-title":"Pathobiol. Aging Age Relat. Dis."},{"key":"3547_CR41","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0304-4165(86)90306-5","volume":"883","author":"RW Farndale","year":"1986","unstructured":"Farndale, R. W., Buttle, D. J. & Barrett, A. J. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim. Biophys. Acta 883, 173\u2013177 (1986).","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/s41586-021-03547-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-021-03547-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/s41586-021-03547-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T18:10:31Z","timestamp":1684606231000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-021-03547-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,12]]},"references-count":41,"journal-issue":{"issue":"7861","published-print":{"date-parts":[[2021,6,3]]}},"alternative-id":["3547"],"URL":"https:\/\/doi.org\/10.1038\/s41586-021-03547-7","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740096221.793586387","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.740096221.793585646","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,12]]},"assertion":[{"value":"4 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"L.J.N. and P.D.R. are co-founders of NRTK Biosciences, a start-up biotechnology company developing senolytic drugs.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}