{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:51:04Z","timestamp":1794271864982,"version":"4.9.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"7881","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2021,10,21]]},"DOI":"10.1038\/s41586-021-03990-6","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T04:22:58Z","timestamp":1633580578000},"page":"504-509","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":214,"title":["A pan-serotype dengue virus\u00a0inhibitor targeting the NS3\u2013NS4B\u00a0interaction"],"prefix":"10.1038","volume":"598","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7935-0219","authenticated-orcid":false,"given":"Suzanne J. F.","family":"Kaptein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Goethals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Kiemel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Marchand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Kesteleyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2107-8857","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"Bonfanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Bardiot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Stoops","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim H. M.","family":"Jonckers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8117-9166","authenticated-orcid":false,"given":"Kai","family":"Dallmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Geluykens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Thys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein","family":"Crabbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7390-8250","authenticated-orcid":false,"given":"Laurent","family":"Chatel-Chaix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"M\u00fcnster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Querat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4734-2249","authenticated-orcid":false,"given":"Franck","family":"Touret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"de Lamballerie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Raboisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny","family":"Simmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Chaltin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5601-9307","authenticated-orcid":false,"given":"Ralf","family":"Bartenschlager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4151-4588","authenticated-orcid":false,"given":"Marnix","family":"Van Loock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0033-7514","authenticated-orcid":false,"given":"Johan","family":"Neyts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,6]]},"reference":[{"key":"3990_CR1","unstructured":"Dengue and Severe Dengue. World Health Organization, https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengue (15 April 2019)."},{"key":"3990_CR2","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature12060","volume":"496","author":"S Bhatt","year":"2013","unstructured":"Bhatt, S. et al. The global distribution and burden of dengue. Nature 496, 504\u2013507 (2013).","journal-title":"Nature"},{"key":"3990_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.5501\/wjv.v6.i1.9","volume":"6","author":"JA Ayukekbong","year":"2017","unstructured":"Ayukekbong, J. A., Oyero, O. G., Nnukwu, S. E., Mesumbe, H. N. & Fobisong, C. N. Value of routine dengue diagnosis in endemic countries. World J. Virol. 6, 9\u201316 (2017).","journal-title":"World J. Virol."},{"key":"3990_CR4","doi-asserted-by":"publisher","first-page":"e000530","DOI":"10.1136\/bmjgh-2017-000530","volume":"3","author":"ES Paix\u00e3o","year":"2018","unstructured":"Paix\u00e3o, E. S., Teixeira, M. G. & Rodrigues, L. C. Zika, chikungunya and dengue: the causes and threats of new and re-emerging arboviral diseases. BMJ Glob. Health 3, e000530 (2018).","journal-title":"BMJ Glob. Health"},{"key":"3990_CR5","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1056\/NEJMra1110265","volume":"366","author":"CP Simmons","year":"2012","unstructured":"Simmons, C. P., Farrar, J. J., van Nguyen, V. & Wills, B. Dengue. N. Engl. J. Med. 366, 1423\u20131432 (2012).","journal-title":"N. Engl. J. Med."},{"key":"3990_CR6","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1038\/s41564-019-0476-8","volume":"4","author":"JP Messina","year":"2019","unstructured":"Messina, J. P. et al. The current and future global distribution and population at risk of dengue. Nat. Microbiol. 4, 1508\u20131515 (2019).","journal-title":"Nat. Microbiol."},{"key":"3990_CR7","doi-asserted-by":"publisher","first-page":"14688","DOI":"10.1073\/pnas.1508114112","volume":"112","author":"V Duong","year":"2015","unstructured":"Duong, V. et al. Asymptomatic humans transmit dengue virus to mosquitoes. Proc. Natl Acad. Sci. USA 112, 14688\u201314693 (2015).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"3990_CR8","doi-asserted-by":"publisher","first-page":"e1006965","DOI":"10.1371\/journal.ppat.1006965","volume":"14","author":"QA ten Bosch","year":"2018","unstructured":"ten Bosch, Q. A. et al. Contributions from the silent majority dominate dengue virus transmission. PLoS Pathog. 14, e1006965 (2018).","journal-title":"PLoS Pathog."},{"key":"3990_CR9","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.12688\/f1000research.7024.1","volume":"4","author":"SB Halstead","year":"2015","unstructured":"Halstead, S. B. Pathogenesis of dengue: dawn of a new era. F1000Research 4, 1353 (2015).","journal-title":"F1000Research"},{"key":"3990_CR10","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1126\/science.aan6836","volume":"358","author":"LC Katzelnick","year":"2017","unstructured":"Katzelnick, L. C. et al. Antibody-dependent enhancement of severe dengue disease in humans. Science 358, 929\u2013932 (2017).","journal-title":"Science"},{"key":"3990_CR11","unstructured":"Dengue vaccine: WHO position paper\u2014July 2016. Wkly Epidemiol. Rec. 91, 349-364 (2016)."},{"key":"3990_CR12","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1016\/S1473-3099(18)30494-8","volume":"19","author":"A Wilder-Smith","year":"2019","unstructured":"Wilder-Smith, A. et al. Deliberations of the strategic advisory group of experts on immunization on the use of CYD-TDV dengue vaccine. Lancet Infect. Dis. 19, e31\u2013e38 (2019).","journal-title":"Lancet Infect. Dis."},{"key":"3990_CR13","unstructured":"Dengue vaccine: WHO position paper\u2014September 2018. Wkly Epidemiol. Rec. 93, 457\u2013476 (2018)."},{"key":"3990_CR14","doi-asserted-by":"crossref","unstructured":"Low, J. G., Gatsinga, R., Vasudevan, S. G. & Sampath, A. In Dengue and Zika: Control and Antiviral Treatment Strategies. Advances in Experimental Medicine and Biology (eds Hilgenfeld, R. & Vasudevan, S. G.) 319\u2013332 (Springer, 2018).","DOI":"10.1007\/978-981-10-8727-1_22"},{"key":"3990_CR15","doi-asserted-by":"publisher","first-page":"e3025","DOI":"10.1371\/journal.pntd.0003025","volume":"8","author":"J Whitehorn","year":"2014","unstructured":"Whitehorn, J. et al. Dengue therapeutics, chemoprophylaxis, and allied tools: state of the art and future directions. PLoS Negl. Trop. Dis. 8, e3025 (2014).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"3990_CR16","doi-asserted-by":"publisher","first-page":"8390","DOI":"10.1021\/acs.jmedchem.8b00913","volume":"61","author":"D Bardiot","year":"2018","unstructured":"Bardiot, D. et al. Discovery of indole derivatives as novel and potent dengue virus inhibitors. J. Med. Chem. 61, 8390\u20138401 (2018).","journal-title":"J. Med. Chem."},{"key":"3990_CR17","doi-asserted-by":"publisher","first-page":"e1004541","DOI":"10.1371\/journal.ppat.1004541","volume":"10","author":"MA Schmid","year":"2014","unstructured":"Schmid, M. A. & Harris, E. Monocyte recruitment to the dermis and differentiation to dendritic cells increases the targets for dengue virus replication. PLoS Pathog. 10, e1004541 (2014).","journal-title":"PLoS Pathog."},{"key":"3990_CR18","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.antiviral.2019.05.005","volume":"168","author":"F Touret","year":"2019","unstructured":"Touret, F. et al. Phylogenetically based establishment of a dengue virus panel, representing all available genotypes, as a tool in dengue drug. Antiviral Res. 168, 109\u2013113 (2019).","journal-title":"Antiviral Res."},{"key":"3990_CR19","doi-asserted-by":"publisher","first-page":"e10077362019","DOI":"10.1371\/journal.ppat.1007736","volume":"15","author":"A P\u0142aszczyca","year":"2019","unstructured":"P\u0142aszczyca, A. et al. A novel interaction between dengue virus nonstructural protein 1 and the NS4A-2K\u20134B precursor is required for viral RNA replication but not for formation of the membranous replication organelle. PLoS Pathog. 15, e10077362019 (2019).","journal-title":"PLoS Pathog."},{"key":"3990_CR20","doi-asserted-by":"publisher","first-page":"7170","DOI":"10.1128\/JVI.00867-15","volume":"89","author":"L Chatel-Chaix","year":"2015","unstructured":"Chatel-Chaix, L. et al. A combined genetic\u2013proteomic approach identifies residues within dengue virus NS4B critical for interaction with NS3 and viral replication. J. Virol. 89, 7170-7186 (2015).","journal-title":"J. Virol."},{"key":"3990_CR21","doi-asserted-by":"publisher","first-page":"eabb2181","DOI":"10.1126\/scitranslmed.abb2181","volume":"13","author":"SA Moquin","year":"2021","unstructured":"Moquin, S. A. et al. NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models. Sci. Transl. Med. 13, eabb2181 (2021).","journal-title":"Sci. Transl. Med."},{"key":"3990_CR22","doi-asserted-by":"publisher","first-page":"20140094","DOI":"10.1098\/rsif.2014.0094","volume":"11","author":"HE Clapham","year":"2014","unstructured":"Clapham, H. E., Tricou, V., Van Vinh Chau, N., Simmons, C. P. & Ferguson, N. M. Within-host viral dynamics of dengue serotype 1 infection. J. R. Soc. Interface 11, 20140094 (2014).","journal-title":"J. R. Soc. Interface"},{"key":"3990_CR23","doi-asserted-by":"publisher","first-page":"e0004052","DOI":"10.1371\/journal.pntd.0004052","volume":"9","author":"S Sim","year":"2015","unstructured":"Sim, S. et al. Tracking dengue virus intra-host genetic diversity during human-to-mosquito transmission. PLoS Negl. Trop. Dis. 9, e0004052 (2015).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"3990_CR24","doi-asserted-by":"publisher","first-page":"7061","DOI":"10.1016\/j.vaccine.2015.09.103","volume":"33","author":"CP Simmons","year":"2015","unstructured":"Simmons, C. P. et al. Recent advances in dengue pathogenesis and clinical management. Vaccine 33, 7061\u20137068 (2015).","journal-title":"Vaccine"},{"key":"3990_CR25","doi-asserted-by":"publisher","first-page":"9072","DOI":"10.1073\/pnas.1303395110","volume":"110","author":"NM Nguyen","year":"2013","unstructured":"Nguyen, N. M. et al. Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes. Proc. Natl Acad. Sci. USA 110, 9072\u20139077 (2013).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"3990_CR26","doi-asserted-by":"publisher","first-page":"e1752","DOI":"10.1371\/journal.pntd.0001752","volume":"6","author":"CP Simmons","year":"2012","unstructured":"Simmons, C. P. et al. Therapeutics for dengue: recommendations for design and conduct of early-phase clinical trials. PLoS Negl. Trop. Dis. 6, e1752 (2012).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"3990_CR27","doi-asserted-by":"publisher","first-page":"S96","DOI":"10.1093\/infdis\/jiw423","volume":"215","author":"JG Low","year":"2017","unstructured":"Low, J. G., Ooi, E. E. & Vasudevan, S. G. Current status of dengue therapeutics research and development. J. Infect. Dis. 215, S96\u2013S102 (2017).","journal-title":"J. Infect. Dis."},{"key":"3990_CR28","unstructured":"Unlocking the Potential of Preventive Therapies for Malaria. World Health Organization, https:\/\/www.who.int\/malaria\/media\/preventive-therapies\/en\/ (7 April 2017)."},{"key":"3990_CR29","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1128\/JVI.03453-14","volume":"89","author":"J Zou","year":"2015","unstructured":"Zou, J. et al. Characterization of dengue virus NS4A and NS4B protein interaction. J. Virol. 89, 3455\u20133470 (2015).","journal-title":"J. Virol."},{"key":"3990_CR30","doi-asserted-by":"publisher","first-page":"8854","DOI":"10.1074\/jbc.M512697200","volume":"281","author":"S Miller","year":"2006","unstructured":"Miller, S., Sparacio, S. & Bartenschlager, R. Subcellular localization and membrane topology of the dengue virus type 2 non-structural protein 4B. J. Biol. Chem. 281, 8854\u20138863 (2006).","journal-title":"J. Biol. Chem."},{"key":"3990_CR31","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.chom.2016.07.008","volume":"20","author":"L Chatel-Chaix","year":"2016","unstructured":"Chatel-Chaix, L. et al. Dengue virus perturbs mitochondrial morphodynamics to dampen innate immune responses. Cell Host Microbe 20, 342\u2013356 (2016).","journal-title":"Cell Host Microbe"},{"key":"3990_CR32","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/rmv.1835","volume":"25","author":"J Zmurko","year":"2015","unstructured":"Zmurko, J., Neyts, J. & Dallmeier, K. Flaviviral NS4B, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention. Rev. Med. Virol. 25, 205\u2013223 (2015).","journal-title":"Rev. Med. Virol."},{"key":"3990_CR33","doi-asserted-by":"publisher","first-page":"2605","DOI":"10.1099\/vir.0.81844-0","volume":"87","author":"I Umareddy","year":"2006","unstructured":"Umareddy, I., Chao, A., Sampath, A., Gu, F. & Vasudevan, S. G. Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA. J. Gen. Virol. 87, 2605\u20132614 (2006).","journal-title":"J. Gen. Virol."},{"key":"3990_CR34","unstructured":"Janssen Pharmaceuticals & KU Leuven. Preparation of mono- or di-substituted derivatives as dengue viral replication inhibitors. Patent WO\/2016\/050841 (2016)."},{"key":"3990_CR35","unstructured":"Janssen Pharmaceuticals & KU Leuven. Preparation of mono- or di-substituted derivatives as dengue viral replication inhibitors. Patent WO\/2016\/050831 (2016)."},{"key":"3990_CR36","unstructured":"Janssen Pharmaceuticals & KU Leuven. Preparation of substituted indoline derivatives as dengue viral replication inhibitors. Patent WO\/2017\/167951 (2017)."},{"key":"3990_CR37","unstructured":"Novartis. N-substituted tetrahydrothienopyridine derivatives as antiviral agents and their preparation. Patent WO\/2019\/244047 (2019)."},{"key":"3990_CR38","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/978-1-62703-484-5_17","volume":"1030","author":"W Fischl","year":"2013","unstructured":"Fischl, W. & Bartenschlager, R. High-throughput screening using dengue virus reporter genomes. Methods Mol. Biol. 1030, 205\u2013219 (2013).","journal-title":"Methods Mol. Biol."},{"key":"3990_CR39","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.1099\/vir.0.068023-0","volume":"95","author":"F Aubry","year":"2014","unstructured":"Aubry, F. et al. Single-stranded positive-sense RNA viruses generated in days using infectious subgenomic amplicons. J. Gen. Virol. 95, 2462\u20132467 (2014).","journal-title":"J. Gen. Virol."},{"key":"3990_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-018-0092-2","volume":"3","author":"DB Kum","year":"2018","unstructured":"Kum, D. B. et al. A yellow fever\u2013Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice. NPJ Vaccines 3, 56 (2018).","journal-title":"NPJ Vaccines"},{"key":"3990_CR41","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.antiviral.2013.01.011","volume":"98","author":"T De Burghgraeve","year":"2013","unstructured":"De Burghgraeve, T. et al. 3\u2032,5\u2032Di-O-trityluridine inhibits in vitro flavivirus replication. Antiviral Res. 98, 242\u2013247 (2013).","journal-title":"Antiviral Res."},{"key":"3990_CR42","doi-asserted-by":"publisher","first-page":"5269","DOI":"10.1128\/AAC.00686-10","volume":"54","author":"SJF Kaptein","year":"2010","unstructured":"Kaptein, S. J. F. et al. A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro. Antimicrob. Agents Chemother. 54, 5269\u20135280 (2010).","journal-title":"Antimicrob. Agents Chemother."},{"key":"3990_CR43","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1093\/bioinformatics\/btu587","volume":"31","author":"BM Verbist","year":"2015","unstructured":"Verbist, B. M. et al. VirVarSeq: a low-frequency virus variant detection pipeline for Illumina sequencing using adaptive base-calling accuracy filtering. Bioinformatics 31, 94\u2013101 (2015).","journal-title":"Bioinformatics"},{"key":"3990_CR44","doi-asserted-by":"publisher","first-page":"E368","DOI":"10.3390\/v10070368","volume":"10","author":"M M\u00fcnster","year":"2018","unstructured":"M\u00fcnster, M. et al. A reverse genetics system for Zika virus based on a simple molecular cloning strategy. Viruses 10, E368 (2018).","journal-title":"Viruses"},{"key":"3990_CR45","doi-asserted-by":"publisher","first-page":"e0004695","DOI":"10.1371\/journal.pntd.0004695","volume":"10","author":"J Zmurko","year":"2016","unstructured":"Zmurko, J. et al. The viral polymerase inhibitor 7-deaza-2\u2032-C-methyladenosine is a potent inhibitor of in vitro Zika virus replication and delays disease progression in a robust mouse infection model. PLoS Negl. Trop. Dis. 10, e0004695 (2016).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"3990_CR46","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/pst.449","volume":"10","author":"T Jaki","year":"2011","unstructured":"Jaki, T. & Wolfsegger, M. J. Estimation of pharmacokinetic parameters with the R package PK. Pharm. Stat. 10, 284\u2013288 (2011).","journal-title":"Pharm. Stat."}],"updated-by":[{"DOI":"10.1038\/s41586-021-04123-9","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-021-03990-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-021-03990-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-021-03990-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T13:28:20Z","timestamp":1684848500000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-021-03990-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,6]]},"references-count":46,"journal-issue":{"issue":"7881","published-print":{"date-parts":[[2021,10,21]]}},"alternative-id":["3990"],"URL":"https:\/\/doi.org\/10.1038\/s41586-021-03990-6","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,6]]},"assertion":[{"value":"30 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41586-021-04123-9","URL":"https:\/\/doi.org\/10.1038\/s41586-021-04123-9","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"S.J.F.K., O.G., A.M., B.K., J.-F.B., D.B., B.S., T.H.M.J., K.D., P.R., K.S., P.C., M.V.L. and J.N. have filed a patent application claiming the discovery of this class of antiviral molecules as DENV replication inhibitors (WO\/2017\/167951). The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}