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G.C.-P. is currently an employee of 23andMe. M.J.C. is the Chief Scientist for Genomics England, a UK Government company. B.M.P. serves on the steering committee of the Yale Open Data Access Project funded by Johnson & Johnson. G.T., A.\u00a0Helgadottir, D.F.G., H.\u00a0Holm., U.T. and K.\u00a0Stefansson are employees of deCODE\/Amgen. V.S. has received honoraria for consultations from Novo Nordisk and Sanofi and has an ongoing research collaboration with Bayer. M.\u00a0McCarthy has served on advisory panels for Pfizer, NovoNordisk and Zoe Global, has received honoraria from Merck, Pfizer, Novo Nordisk and Eli Lilly, and research funding from Abbvie, Astra Zeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, NovoNordisk, Pfizer, Roche, Sanofi Aventis, Servier and Takeda. M.\u00a0McCarthy and A.\u00a0Mahajan are employees of Genentech and are holders of Roche stock. M.\u00a0Scholz receives funding from Pfizer for a project unrelated to this work. M.E.K. is employed by Synlab. W.M. has received grants from Siemens Healthineers, grants and personal fees from Aegerion Pharmaceuticals, grants and personal fees from Amgen, grants from AstraZeneca, grants and personal fees from Sanofi, grants and personal fees from Alexion Pharmaceuticals, grants and personal fees from BASF, grants and personal fees from Abbott Diagnostics, grants and personal fees from Numares, grants and personal fees from Berlin-Chemie, grants and personal fees from Akzea Therapeutics, grants from Bayer Vital, grants from bestbion dx, grants from Boehringer Ingelheim, grants from Immundiagnostik, grants from Merck Chemicals, grants from MSD Sharp and Dohme, grants from Novartis Pharma, grants from Olink Proteomics, and is employed by Synlab Holding Deutschland, all outside the submitted work. A.V.K. has served as a consultant to Sanofi, Medicines Company, Maze Pharmaceuticals, Navitor Pharmaceuticals, Verve Therapeutics, Amgen and Color Genomics; received speaking fees from Illumina, the Novartis Institute for Biomedical Research; received sponsored research agreements from the Novartis Institute for Biomedical Research and IBM Research; and reports a patent related to a genetic risk predictor (20190017119). S.K. is an employee of Verve Therapeutics and holds equity in Verve Therapeutics, Maze Therapeutics, Catabasis and San Therapeutics. He is a member of the scientific advisory boards for Regeneron Genetics Center and Corvidia Therapeutics; he has served as a consultant for Acceleron, Eli Lilly, Novartis, Merck, Novo Nordisk, Novo Ventures, Ionis, Alnylam, Aegerion, Haug Partners, Noble Insights, Leerink Partners, Bayer Healthcare, Illumina, Color Genomics, MedGenome, Quest and Medscape; and reports patents related to a method of identifying and treating a person having a predisposition to or afflicted with cardiometabolic disease (20180010185) and a genetics risk predictor (20190017119). D.K. accepts consulting fees from Regeneron Pharmaceuticals. D.O.M.-K. is a part-time clinical research consultant for Metabolon. D.S. has received support from the British Heart Foundation, Pfizer, Regeneron, Genentech and Eli Lilly pharmaceuticals. The spouse of C.J.W. is employed by Regeneron.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}