{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:53:07Z","timestamp":1794271987753,"version":"4.9.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7936","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2022,11,17]]},"DOI":"10.1038\/s41586-022-05397-3","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T12:04:26Z","timestamp":1667995466000},"page":"585-593","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":315,"title":["Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid"],"prefix":"10.1038","volume":"611","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-4719","authenticated-orcid":false,"given":"Antoine","family":"Drieu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siling","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-2264","authenticated-orcid":false,"given":"Steffen E.","family":"Storck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Rustenhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5681-1388","authenticated-orcid":false,"given":"Zachary","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-809X","authenticated-orcid":false,"given":"Taitea","family":"Dykstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghe","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungdeok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Blackburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7088-3967","authenticated-orcid":false,"given":"Tornike","family":"Mamuladze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2635-6975","authenticated-orcid":false,"given":"Oscar","family":"Harari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6854-5547","authenticated-orcid":false,"given":"Celeste M.","family":"Karch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-1702","authenticated-orcid":false,"given":"Randall J.","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3443-7716","authenticated-orcid":false,"given":"Richard","family":"Perrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Farlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7792-1698","authenticated-orcid":false,"given":"Jasmeer","family":"Chhatwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Dominantly Inherited Alzheimer Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Brosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Buck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marty","family":"Farlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardino","family":"Ghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Barthelemy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie","family":"Benzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Brandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Buckles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Cash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cruchaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcy","family":"Denner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Dincer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Donahue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becca","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaney","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Joseph-Mathurin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Gremminger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Groves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hassenstab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cortaiga","family":"Hellm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Herries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Hoechst-Swisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russ","family":"Hornbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Jerome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Keefe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deb","family":"Koudelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwasi","family":"Mawuenyega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"McCullough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"McDade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Norton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Shady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Sigurdson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjie","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Allegri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio Chrem","family":"Mendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Egido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ikeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensaku","family":"Kasuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Bechara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Berman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snezana","family":"Ikonomovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Klunk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mountz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelesh","family":"Nadkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riddhi","family":"Patira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Snitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Weamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Bodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Salloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duc","family":"Duong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Levey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas T.","family":"Seyfried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Chui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ringman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neill","family":"Graff-Radford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sochenda","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrismary De La","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Mejia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Neimeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Noble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Diffenbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Yakushev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"V\u00f6glein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Grilo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cath","family":"Mummery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Goate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Renton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Senda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Gardener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Sohrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Taddei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Gr\u00e4ber-Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"H\u00e4sler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Jucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"K\u00e4ser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Kuder-Buletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Laske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Preische","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Haass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estrella","family":"Morenas-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Nuscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Nagamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford","family":"Jack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Koeppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal Scott","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulricke","family":"Oberm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9045-1195","authenticated-orcid":false,"given":"Gwendalyn J.","family":"Randolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Smirnov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-517X","authenticated-orcid":false,"given":"Jonathan","family":"Kipnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"5397_CR1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.immuni.2016.02.024","volume":"44","author":"F Ginhoux","year":"2016","unstructured":"Ginhoux, F. & Guilliams, M. Tissue-resident macrophage ontogeny and homeostasis. Immunity 44, 439\u2013449 (2016).","journal-title":"Immunity"},{"key":"5397_CR2","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/s41586-022-04596-2","volume":"604","author":"T Masuda","year":"2022","unstructured":"Masuda, T. et al. Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature 604, 740\u2013748 (2022).","journal-title":"Nature"},{"key":"5397_CR3","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1038\/s41590-020-0776-4","volume":"21","author":"K Alves de Lima","year":"2020","unstructured":"Alves de Lima, K. et al. Meningeal \u03b3\u03b4 T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nat. Immunol. 21, 1421\u20131429 (2020).","journal-title":"Nat. Immunol."},{"key":"5397_CR4","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/nature18626","volume":"535","author":"AJ Filiano","year":"2016","unstructured":"Filiano, A. J. et al. Unexpected role of interferon-\u03b3 in regulating neuronal connectivity and social behaviour. Nature 535, 425\u2013429 (2016).","journal-title":"Nature"},{"key":"5397_CR5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/S0166-2236(00)02088-9","volume":"25","author":"JP Konsman","year":"2002","unstructured":"Konsman, J. P., Parnet, P. & Dantzer, R. Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci. 25, 154\u2013159 (2002).","journal-title":"Trends Neurosci."},{"key":"5397_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07318-3","volume":"9","author":"H Mestre","year":"2018","unstructured":"Mestre, H. et al. Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nat. Commun. 9, 4878 (2018).","journal-title":"Nat. Commun."},{"key":"5397_CR7","doi-asserted-by":"publisher","first-page":"18190","DOI":"10.1523\/JNEUROSCI.1592-13.2013","volume":"33","author":"JJ Iliff","year":"2013","unstructured":"Iliff, J. J. et al. Cerebral arterial pulsation drives paravascular CSF\u2013interstitial fluid exchange in the murine brain. J. Neurosci. 33, 18190\u201318199 (2013).","journal-title":"J. Neurosci."},{"key":"5397_CR8","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.neuron.2019.10.033","volume":"105","author":"SJ van Veluw","year":"2020","unstructured":"van Veluw, S. J. et al. Vasomotion as a driving force for paravascular clearance in the awake mouse brain. Neuron 105, 549\u2013561.e5 (2020).","journal-title":"Neuron"},{"key":"5397_CR9","doi-asserted-by":"publisher","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","volume":"4","author":"JJ Iliff","year":"2012","unstructured":"Iliff, J. J. et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2. Sci. Transl Med. 4, 147ra111 (2012).","journal-title":"Sci. Transl Med."},{"key":"5397_CR10","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature14432","volume":"523","author":"A Louveau","year":"2015","unstructured":"Louveau, A. et al. Structural and functional features of central nervous system lymphatic vessels. Nature 523, 337\u2013341 (2015).","journal-title":"Nature"},{"key":"5397_CR11","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/s41593-022-01063-z","volume":"25","author":"X Li","year":"2022","unstructured":"Li, X. et al. Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system. Nat. Neurosci. 25, 577\u2013587 (2022).","journal-title":"Nat. Neurosci."},{"key":"5397_CR12","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2020.12.040","volume":"184","author":"J Rustenhoven","year":"2021","unstructured":"Rustenhoven, J. et al. Functional characterization of the dural sinuses as a neuroimmune interface. Cell 184, 1000\u20131016.e27 (2021).","journal-title":"Cell"},{"key":"5397_CR13","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/s41583-019-0201-x","volume":"20","author":"K Kierdorf","year":"2019","unstructured":"Kierdorf, K., Masuda, T., Jord\u00e3o, M. J. C. & Prinz, M. Macrophages at CNS interfaces: ontogeny and function in health and disease. Nat. Rev. Neurosci. 20, 547\u2013562 (2019).","journal-title":"Nat. Rev. Neurosci."},{"key":"5397_CR14","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s00109-017-1573-x","volume":"95","author":"G Faraco","year":"2017","unstructured":"Faraco, G., Park, L., Anrather, J. & Iadecola, C. Brain perivascular macrophages: characterization and functional roles in health and disease. J. Mol. Med. 95, 1143\u20131152 (2017).","journal-title":"J. Mol. Med."},{"key":"5397_CR15","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/s41593-019-0393-4","volume":"22","author":"H Van Hove","year":"2019","unstructured":"Van Hove, H. et al. A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. Nat. Neurosci. 22, 1021\u20131035 (2019).","journal-title":"Nat. Neurosci."},{"key":"5397_CR16","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/ni.3423","volume":"17","author":"T Goldmann","year":"2016","unstructured":"Goldmann, T. et al. Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat. Immunol. 17, 797\u2013805 (2016).","journal-title":"Nat. Immunol."},{"key":"5397_CR17","doi-asserted-by":"publisher","first-page":"4674","DOI":"10.1172\/JCI86950","volume":"126","author":"G Faraco","year":"2016","unstructured":"Faraco, G. et al. Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension. J. Clin. Invest. 126, 4674\u20134689 (2016).","journal-title":"J. Clin. Invest."},{"key":"5397_CR18","doi-asserted-by":"publisher","first-page":"20816","DOI":"10.1073\/pnas.1005888107","volume":"107","author":"K Thanopoulou","year":"2010","unstructured":"Thanopoulou, K., Fragkouli, A., Stylianopoulou, F. & Georgopoulos, S. Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model. Proc. Natl Acad. Sci. USA 107, 20816\u201320821 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"5397_CR19","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1161\/CIRCRESAHA.117.311054","volume":"121","author":"L Park","year":"2017","unstructured":"Park, L. et al. Brain perivascular macrophages initiate the neurovascular dysfunction of Alzheimer A\u03b2 peptides. Circ. Res. 121, 258\u2013269 (2017).","journal-title":"Circ. Res."},{"key":"5397_CR20","doi-asserted-by":"publisher","first-page":"eaat7554","DOI":"10.1126\/science.aat7554","volume":"363","author":"MJC Jord\u00e3o","year":"2019","unstructured":"Jord\u00e3o, M. J. C. et al. Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Science 363, eaat7554 (2019).","journal-title":"Science"},{"key":"5397_CR21","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.immuni.2018.01.011","volume":"48","author":"D Mrdjen","year":"2018","unstructured":"Mrdjen, D. et al. High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease. Immunity 48, 380\u2013395.e6 (2018).","journal-title":"Immunity"},{"key":"5397_CR22","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41582-020-0312-z","volume":"16","author":"JM Wardlaw","year":"2020","unstructured":"Wardlaw, J. M. et al. Perivascular spaces in the brain: anatomy, physiology and pathology. Nat. Rev. Neurol. 16, 137\u2013153 (2020).","journal-title":"Nat. Rev. Neurol."},{"key":"5397_CR23","doi-asserted-by":"publisher","first-page":"e40070","DOI":"10.7554\/eLife.40070","volume":"7","author":"H Mestre","year":"2018","unstructured":"Mestre, H. et al. Aquaporin-4-dependent glymphatic solute transport in the rodent brain. eLife 7, e40070 (2018).","journal-title":"eLife"},{"key":"5397_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-107","volume":"11","author":"L Yang","year":"2013","unstructured":"Yang, L. et al. Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer. J. Transl Med. 11, 107 (2013).","journal-title":"J. Transl Med"},{"key":"5397_CR25","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/s41586-018-0368-8","volume":"560","author":"S Da Mesquita","year":"2018","unstructured":"Da Mesquita, S. et al. Functional aspects of meningeal lymphatics in ageing and Alzheimer\u2019s disease. Nature 560, 185\u2013191 (2018).","journal-title":"Nature"},{"key":"5397_CR26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/s41586-019-1419-5","volume":"572","author":"JH Ahn","year":"2019","unstructured":"Ahn, J. H. et al. Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid. Nature 572, 62\u201366 (2019).","journal-title":"Nature"},{"key":"5397_CR27","doi-asserted-by":"publisher","first-page":"eaax7171","DOI":"10.1126\/science.aax7171","volume":"367","author":"H Mestre","year":"2020","unstructured":"Mestre, H. et al. Cerebrospinal fluid influx drives acute ischemic tissue swelling. Science 367, eaax7171 (2020).","journal-title":"Science"},{"key":"5397_CR28","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/S0165-5728(01)00282-X","volume":"116","author":"MM Polfliet","year":"2001","unstructured":"Polfliet, M. M. et al. A method for the selective depletion of perivascular and meningeal macrophages in the central nervous system. J. Neuroimmunol. 116, 188\u2013195 (2001).","journal-title":"J. Neuroimmunol."},{"key":"5397_CR29","doi-asserted-by":"publisher","first-page":"eaav5447","DOI":"10.1126\/sciadv.aav5447","volume":"5","author":"LM Hablitz","year":"2019","unstructured":"Hablitz, L. M. et al. Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia. Sci. Adv. 5, eaav5447 (2019).","journal-title":"Sci. Adv."},{"key":"5397_CR30","doi-asserted-by":"publisher","first-page":"710","DOI":"10.7150\/thno.19154","volume":"8","author":"C Gakuba","year":"2018","unstructured":"Gakuba, C. et al. General anesthesia inhibits the activity of the \u2018glymphatic system\u2019. Theranostics 8, 710\u2013722 (2018).","journal-title":"Theranostics"},{"key":"5397_CR31","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.immuni.2018.06.008","volume":"49","author":"HY Lim","year":"2018","unstructured":"Lim, H. Y. et al. Hyaluronan receptor LYVE-1-expressing macrophages maintain arterial tone through hyaluronan-mediated regulation of smooth muscle cell collagen. Immunity 49, 326\u2013341.e7 (2018).","journal-title":"Immunity"},{"key":"5397_CR32","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/s41586-020-2026-1","volume":"579","author":"BW Chow","year":"2020","unstructured":"Chow, B. W. et al. Caveolae in CNS arterioles mediate neurovascular coupling. Nature 579, 106\u2013110 (2020).","journal-title":"Nature"},{"key":"5397_CR33","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41556-019-0439-6","volume":"22","author":"C Baccin","year":"2020","unstructured":"Baccin, C. et al. Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Nat. Cell Biol. 22, 38\u201348 (2020).","journal-title":"Nat. Cell Biol."},{"key":"5397_CR34","doi-asserted-by":"publisher","first-page":"e20210924","DOI":"10.1084\/jem.20210924","volume":"218","author":"N Zhang","year":"2021","unstructured":"Zhang, N. et al. LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth. J. Exp. Med. 218, e20210924 (2021).","journal-title":"J. Exp. Med."},{"key":"5397_CR35","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1093\/brain\/awn331","volume":"132","author":"V Boissonneault","year":"2009","unstructured":"Boissonneault, V. et al. Powerful beneficial effects of macrophage colony-stimulating factor on \u03b2-amyloid deposition and cognitive impairment in Alzheimer\u2019s disease. Brain 132, 1078\u20131092 (2009).","journal-title":"Brain"},{"key":"5397_CR36","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1073\/pnas.0805453106","volume":"106","author":"CA Hawkes","year":"2009","unstructured":"Hawkes, C. A. & McLaurin, J. Selective targeting of perivascular macrophages for clearance of \u03b2-amyloid in cerebral amyloid angiopathy. Proc. Natl Acad. Sci. USA 106, 1261\u20131266 (2009).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"5397_CR37","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","volume":"169","author":"H Keren-Shaul","year":"2017","unstructured":"Keren-Shaul, H. et al. A unique microglia type associated with restricting development of Alzheimer\u2019s disease. Cell 169, 1276\u20131290.e17 (2017).","journal-title":"Cell"},{"key":"5397_CR38","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/s41586-021-03489-0","volume":"593","author":"S Da Mesquita","year":"2021","unstructured":"Da Mesquita, S. et al. Meningeal lymphatics affect microglia responses and anti-A\u03b2 immunotherapy. Nature 593, 255\u2013260 (2021).","journal-title":"Nature"},{"key":"5397_CR39","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.cell.2020.03.021","volume":"181","author":"SG Utz","year":"2020","unstructured":"Utz, S. G. et al. Early fate defines microglia and non-parenchymal brain macrophage development. Cell 181, 557\u2013573.e18 (2020).","journal-title":"Cell"},{"key":"5397_CR40","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1111\/micc.12064","volume":"20","author":"PW Pires","year":"2013","unstructured":"Pires, P. W. et al. Improvement in middle cerebral artery structure and endothelial function in stroke-prone spontaneously hypertensive rats after macrophage depletion. Microcirculation 20, 650\u2013661 (2013).","journal-title":"Microcirculation"},{"key":"5397_CR41","doi-asserted-by":"publisher","first-page":"e20211071","DOI":"10.1084\/jem.20211071","volume":"219","author":"E Cs\u00e1sz\u00e1r","year":"2022","unstructured":"Cs\u00e1sz\u00e1r, E. et al. Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions. J. Exp. Med. 219, e20211071 (2022).","journal-title":"J. Exp. Med."},{"key":"5397_CR42","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/978-1-4939-6747-6_2","volume":"1550","author":"J Erde","year":"2017","unstructured":"Erde, J., Loo, R. R. O. & Loo, J. A. Improving proteome coverage and sample recovery with enhanced FASP (eFASP) for quantitative proteomic experiments. Methods Mol. Biol. 1550, 11\u201318 (2017).","journal-title":"Methods Mol. Biol."},{"key":"5397_CR43","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1038\/nprot.2007.261","volume":"2","author":"J Rappsilber","year":"2007","unstructured":"Rappsilber, J., Mann, M. & Ishihama, Y. Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nat. Protoc. 2, 1896\u20131906 (2007).","journal-title":"Nat. Protoc."},{"key":"5397_CR44","doi-asserted-by":"crossref","unstructured":"Cai, R. et al. Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull\u2013meninges connections. Nat. Neurosci. 22, 317\u2013327 (2019).","DOI":"10.1038\/s41593-018-0301-3"},{"key":"5397_CR45","first-page":"2122","volume":"5","author":"ATL Lun","year":"2016","unstructured":"Lun, A. T. L., McCarthy, D. J. & Marioni, J. C. A step-by-step workflow for low-level analysis of single-cell RNA-seq data with Bioconductor. F1000Research 5, 2122 (2016).","journal-title":"F1000Research"},{"key":"5397_CR46","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/bioinformatics\/btw777","volume":"33","author":"DJ McCarthy","year":"2017","unstructured":"McCarthy, D. J., Campbell, K. R., Lun, A. T. L. & Wills, Q. F. Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R. Bioinformatics 33, 1179\u20131186 (2017).","journal-title":"Bioinformatics"},{"key":"5397_CR47","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol. 36, 411\u2013420 (2018).","journal-title":"Nat. Biotechnol."},{"key":"5397_CR48","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1406-4","volume":"19","author":"K Van den Berge","year":"2018","unstructured":"Van den Berge, K. et al. Observation weights unlock bulk RNA-seq tools for zero inflation and single-cell applications. Genome Biol. 19, 24 (2018).","journal-title":"Genome Biol."},{"key":"5397_CR49","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139\u2013140 (2010).","journal-title":"Bioinformatics"},{"key":"5397_CR50","doi-asserted-by":"publisher","first-page":"20130950","DOI":"10.1098\/rsif.2013.0950","volume":"11","author":"G Hong","year":"2014","unstructured":"Hong, G., Zhang, W., Li, H., Shen, X. & Guo, Z. Separate enrichment analysis of pathways for up- and downregulated genes. J. R. Soc. Interface 11, 20130950 (2014).","journal-title":"J. R. Soc. Interface"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41586-022-05397-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-022-05397-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41586-022-05397-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T11:17:47Z","timestamp":1678533467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41586-022-05397-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,9]]},"references-count":50,"journal-issue":{"issue":"7936","published-print":{"date-parts":[[2022,11,17]]}},"alternative-id":["5397"],"URL":"https:\/\/doi.org\/10.1038\/s41586-022-05397-3","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,9]]},"assertion":[{"value":"18 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"J.K. is a scientific advisor and collaborator with PureTech. J.K. and A.D. are holding provisional patent applications related to the findings described herein. R.J.B co-founded and is on the scientific advisory board of C2N Diagnostics. C2N Diagnostics has licensed certain anti-tau antibodies to AbbVie for therapeutic development. He receives research support from Biogen, Eisai and the DIAN-TU Pharma Consortium. He is also an advisor to Amgen and Hoffman La-Roche.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}